[ { "uniprot_canonical_ac": "Q8BP92-1", "uniprot_id": [ { "id": "RCN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP92", "type": "external" } ], "mass": 37271.0, "length": 320, "protein_name": "Reticulocalbin-2", "gene_name": "Rcn2", "organism": "Mouse", "refseq_name": "reticulocalbin-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_036122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036122", "type": "external" } ], "gene_names_uniprotkb": "Rcn2", "gene_names_refseq": "Rcn2; Tcbp49", "protein_names_uniprotkb": "Reticulocalbin-2; TCBP-49; Taipoxin-associated calcium-binding protein 49", "protein_names_refseq": "reticulocalbin-2 isoform 1 precursor; taipoxin-associated calcium binding protein 49", "tax_id": 10090, "disease": "", "pathway": " (mmu:26611)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17767500;21750661;25428506;26495903;32848054;36952101;38795835", "class_list": "", "function": "Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2., [RefSeq, PubMed]; Not known. Binds calcium (By similarity)., [UniProtKB]; RCAN2 was highly expressed in scattered neurons, in both the nucleus and the cytoplasm. RCAN2 is the only member of the RCAN family that was detected in glial cells., [RefSeq, PubMed]; RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2RT07;O70341", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BP92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYF1-1", "uniprot_id": [ { "id": "RDH11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYF1", "type": "external" } ], "mass": 35148.0, "length": 316, "protein_name": "Retinol dehydrogenase 11", "gene_name": "Rdh11", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 11 isoform 1", "refseq_ac": [ { "id": "NP_067532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067532", "type": "external" } ], "gene_names_uniprotkb": "Rdh11; Arsdr1; Mdt1; Psdr1", "gene_names_refseq": "2610319N22Rik; Arsdr1; CGI-82; HCBP12; M42C60; Mdt1; Psdr1; Rdh11; SCALD; UBE-1c1; Ube-1c; ralR1", "protein_names_uniprotkb": "Retinol dehydrogenase 11; 1.1.1.300; Androgen-regulated short-chain dehydrogenase/reductase 1; Cell line MC/9.IL4-derived protein 1; M42C60; Prostate short-chain dehydrogenase/reductase 1; RalR1; Retinal reductase 1; SCALD; Short-chain aldehyde dehydrogenase", "protein_names_refseq": "all-trans and 9-cis; androgen-regulated short-chain dehydrogenase/reductase 1; cell line MC/9.IL4 derived transcript 1; cell line MC/9.IL4-derived protein 1; prostate short-chain dehydrogenase/reductase 1; retinal reductase 1; retinol dehydrogenase 11 isoform 1; short-chain aldehyde dehydrogenase", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:17252); (R-MMU-2453902); (R-MMU-5365859); (R-MMU-975634)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12137953;12807874;15634683;15790565;21750661;26495903;29567832;31219806;34428180;8018917", "class_list": "", "function": "Characterization of catalytic properties and tissue distribution, [RefSeq, PubMed]; Propose that mouse retinol dehydrogenase 11(mRDH11) disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis, [RefSeq, PubMed]; RDH11 has a measurable role in regenerating the visual pigment by complementing RDH5 in retinal pigment epithelium., [RefSeq, PubMed]; Results indicate that in mouse testis and liver, RDH11 functions as an all-trans-retinaldehyde reductase essential for the maintenance of physiological levels of all-trans-retinol under reduced vitamin A availability, [RefSeq, PubMed]; Retinol dehydrogenase with a clear preference for NADP (PubMed:12807874, PubMed:29567832). Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (By similarity) (PubMed:12807874). Also exhibits reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal (PubMed:12807874). Has no dehydrogenase activity towards steroid (PubMed:12807874). Seems to be required for homeostasis of retinol in liver and testis (PubMed:29567832)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXM9;Q9D0U5", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0033721 aldehyde dehydrogenase (NADP+) activity;GO:0102354 11-cis-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0042574 retinal metabolic process;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QYF1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ96-1", "uniprot_id": [ { "id": "RASF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ96", "type": "external" } ], "mass": 48103.0, "length": 419, "protein_name": "Ras association domain-containing protein 8", "gene_name": "Rassf8", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 8", "refseq_ac": [ { "id": "NP_082036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082036", "type": "external" } ], "gene_names_uniprotkb": "Rassf8", "gene_names_refseq": "5133400D11Rik; Hoj1; Rassf8; mHoj-1", "protein_names_uniprotkb": "Ras association domain-containing protein 8; Carcinoma-associated protein HOJ-1 homolog", "protein_names_refseq": "carcinoma-associated protein HOJ-1 homolog; ras association domain-containing protein 8", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:71323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149Q5;Q8CCW4;Q9CU91", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CJ96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQK3-1", "uniprot_id": [ { "id": "RDM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQK3", "type": "external" } ], "mass": 31235.0, "length": 281, "protein_name": "RAD52 motif-containing protein 1", "gene_name": "Rdm1", "organism": "Mouse", "refseq_name": "RAD52 motif-containing protein 1", "refseq_ac": [ { "id": "NP_079930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079930", "type": "external" } ], "gene_names_uniprotkb": "Rdm1", "gene_names_refseq": "2410008M22Rik; Rad52b; Rdm1", "protein_names_uniprotkb": "RAD52 motif-containing protein 1", "protein_names_refseq": "RAD52 homolog B; RAD52 motif-containing protein 1; RAD52B homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66599)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25605945;30084848;34428180", "class_list": "", "function": "May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016605 PML body;GO:0015030 Cajal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQP8-1", "uniprot_id": [ { "id": "RFIP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQP8", "type": "external" } ], "mass": 71901.0, "length": 635, "protein_name": "Rab11 family-interacting protein 4", "gene_name": "Rab11fip4", "organism": "Mouse", "refseq_name": "rab11 family-interacting protein 4", "refseq_ac": [ { "id": "NP_780752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780752", "type": "external" } ], "gene_names_uniprotkb": "Rab11fip4; Kiaa1821", "gene_names_refseq": "A730072L08Rik; RAB11-FIP4; Rab11fip4; mKIAA1821", "protein_names_uniprotkb": "Rab11 family-interacting protein 4; FIP4-Rab11; Rab11-FIP4; mRab11-FIP4A", "protein_names_refseq": "FIP4-Rab11; mRab11-FIP4A; rab11 family-interacting protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:268451)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12857874;17089410;21750661;29257314;30295969", "class_list": "", "function": "Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development, in a Rab11-independent manner., [UniProtKB, PubMed]; FIP4 and FIP3 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation., [RefSeq, PubMed]; Identification of Rab11-family interacting protein 4 (Rab11-FIP4) as a gene strongly expressed in the developing mouse retina., [RefSeq, PubMed]; Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80T87", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0055038 recycling endosome membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0003407 neural retina development;GO:0051301 cell division;GO:0032456 endocytic recycling;GO:0032465 regulation of cytokinesis;GO:1903452 positive regulation of G1 to G0 transition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BQP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCG9-1", "uniprot_id": [ { "id": "RFXAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCG9", "type": "external" } ], "mass": 24787.0, "length": 231, "protein_name": "Regulatory factor X-associated protein", "gene_name": "Rfxap", "organism": "Mouse", "refseq_name": "regulatory factor X-associated protein", "refseq_ac": [ { "id": "NP_573494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573494", "type": "external" } ], "gene_names_uniprotkb": "Rfxap", "gene_names_refseq": "5730495K23Rik; Rfxap", "protein_names_uniprotkb": "Regulatory factor X-associated protein; RFX-associated protein", "protein_names_refseq": "RFX-associated protein; regulatory factor X-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:170767)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11486010;21750661;30084848;30779550", "class_list": "", "function": "Invitro transcription/translation and transfection studies described here show that non-AUG (ACG) codon functions as a translation initiation codon., [RefSeq, PubMed]; Part of the RFX complex that binds to the X-box of MHC II promoters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y54", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61193-1", "uniprot_id": [ { "id": "RGL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61193", "type": "external" } ], "mass": 83826.0, "length": 778, "protein_name": "Ral guanine nucleotide dissociation stimulator-like 2", "gene_name": "Rgl2", "organism": "Mouse", "refseq_name": "ral guanine nucleotide dissociation stimulator-like 2 isoform 1", "refseq_ac": [ { "id": "NP_033085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033085", "type": "external" } ], "gene_names_uniprotkb": "Rgl2; Rab2l; Rlf", "gene_names_refseq": "KE1.5; Rab2l; Rgl2; Rgt2; Rlf", "protein_names_uniprotkb": "Ral guanine nucleotide dissociation stimulator-like 2; RalGDS-like 2; RalGDS-like factor; Ras-associated protein RAB2L", "protein_names_refseq": "RalGDS-like factor; ral guanine nucleotide dissociation stimulator-like 2 isoform 1; ralGDS-like 2; ras-associated protein RAB2L", "tax_id": 10090, "disease": "", "pathway": " (mmu:19732)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11847222;21750661;23891840;8710374;9753431", "class_list": "", "function": "Induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses, [RefSeq, PubMed]; Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro., [UniProtKB]; The crystal structure of the mouse Rgl2 REM- and a CDC25-homology domain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUJ2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0032485 regulation of Ral protein signal transduction;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61193-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP95-1", "uniprot_id": [ { "id": "RETNA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP95", "type": "external" } ], "mass": 11936.0, "length": 111, "protein_name": "Resistin-like alpha", "gene_name": "Retnla", "organism": "Mouse", "refseq_name": "resistin-like alpha precursor", "refseq_ac": [ { "id": "NP_065255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065255", "type": "external" } ], "gene_names_uniprotkb": "Retnla; Fizz1; Himf; Pmng1", "gene_names_refseq": "1810019L16Rik; Fizz-1; Fizz1; HIMF; RELM-alpha; RELMalpha; RELMa; Retnla; Xcp2", "protein_names_uniprotkb": "Resistin-like alpha; Cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Hypoxia-induced mitogenic factor; Parasite-induced macrophage novel gene 1 protein; RELMalpha", "protein_names_refseq": "cysteine-rich secreted protein A12-gamma; cysteine-rich secreted protein FIZZ1; found in inflammatory zone 1; hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; resistin-like alpha precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:57262)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10921885;11209052;11358969;12145345;12163041;20582166;21750661;34349768;37747879", "class_list": "", "function": "Choline metabolism underpins macrophage IL-4 polarization and RELMalpha up-regulation in helminth infection. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule alpha. Publication Status: Online-Only, [RefSeq, PubMed]; Probable hormone. Plays a role in pulmonary vascular remodeling., [UniProtKB, PubMed]; RELM-alpha mRNA in white adipose tissue fell by approximately 40% in early lactation; might indicate a role for RELM-alpha in the metabolic adaptations of lactation., [RefSeq, PubMed]; The expression of resistin and RELMalpha are similarly regulated in adipose tissue despite the fact that RELMalpha is exclusively expressed in the stromal vascular fraction of adipose tissue and not in adipocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8Y4", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0010269 response to selenium ion;GO:0009624 response to nematode", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EP95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43352-1", "uniprot_id": [ { "id": "RAD52_MOUSE", "url": "https://www.uniprot.org/uniprot/P43352", "type": "external" } ], "mass": 46910.0, "length": 420, "protein_name": "DNA repair protein RAD52 homolog", "gene_name": "Rad52", "organism": "Mouse", "refseq_name": "DNA repair protein RAD52 homolog isoform 1", "refseq_ac": [ { "id": "NP_001159853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159853", "type": "external" } ], "gene_names_uniprotkb": "Rad52", "gene_names_refseq": "Rad52yh; Rad52", "protein_names_uniprotkb": "DNA repair protein RAD52 homolog", "protein_names_refseq": "DNA repair protein RAD52 homolog isoform 1; DNA repair protein RAD52 homolog", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); salivary gland carcinoma (Disease Ontology:DOID:0050904); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:19365); (R-MMU-3108214); (R-MMU-5685938); (R-MMU-5685939)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "21750661;28415565;30022024;32782141;32848054;33440161;34887587;35190531;40885482;7526206;7774919;7829098", "class_list": "", "function": "Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3alpha Co-localization., [RefSeq, PubMed]; Rad52 mediates class-switch DNA recombination to IgD. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that Rad52 depletion increased cell death, decreased myeloid cell frequency, and augmented the activity of CD8+ T cells and NK effectors that ultimately led to reduced tumor growth. These data provide support for the notion of RAD52 as a potential oncogene, implicating a major role for the combined processes of recombinational repair and host immunity in determining risk for Squamous Cell., [RefSeq, PubMed]; Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006312 mitotic recombination;GO:2000819 regulation of nucleotide-excision repair;GO:0045002 double-strand break repair via single-strand annealing;GO:0006310 DNA recombination;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43352-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YQ1-1", "uniprot_id": [ { "id": "RAB7L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YQ1", "type": "external" } ], "mass": 23089.0, "length": 204, "protein_name": "Ras-related protein Rab-29", "gene_name": "Rab29", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rab29; Rab7l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-29; 3.6.5.2; Rab-7-like protein 1; Ras-related protein Rab-7L1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:226422); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;23395371", "class_list": "", "function": "The small GTPases Rab are key regulators in vesicle trafficking., [UniProtKB, UniProtKB]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB29 is essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity. Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (By similarity). Also regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030154 cell differentiation;GO:0090316 positive regulation of intracellular protein transport;GO:0042110 T cell activation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91YQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZQ6-1", "uniprot_id": [ { "id": "RAE1E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZQ6", "type": "external" } ], "mass": 28284.0, "length": 251, "protein_name": "Retinoic acid early-inducible protein 1-epsilon", "gene_name": "Raet1e", "organism": "Mouse", "refseq_name": "retinoic acid early-inducible protein 1-epsilon precursor", "refseq_ac": [ { "id": "NP_937836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937836", "type": "external" } ], "gene_names_uniprotkb": "Raet1e", "gene_names_refseq": "Raet1e", "protein_names_uniprotkb": "Retinoic acid early-inducible protein 1-epsilon; RAE-1-epsilon", "protein_names_refseq": "Rae-1 epsilon; retinoic acid early-inducible protein 1-epsilon precursor; retinoic acid early-inducible protein 1-epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:379043); (R-MMU-198933)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11567106;16086018;20166740;21750661;27444966", "class_list": "", "function": "Acts as a ligand for KLRK1., [UniProtKB, PubMed, PubMed]; Study reports that retinoic acid early induced transcript-1-d and retinoic acid early induced transcript-1-e (Raet1) genes are induced early upon experimental autoimmune encephalomyelitis onset and reach a maximal expression at the peak of the pathology. Study also shows that macrophages as well as microglia, are cellular sources of Raet1 transcripts., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2RSZ5", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0001913 T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CZQ6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08602-1", "uniprot_id": [ { "id": "RAE1A_MOUSE", "url": "https://www.uniprot.org/uniprot/O08602", "type": "external" } ], "mass": 28616.0, "length": 253, "protein_name": "Retinoic acid early-inducible protein 1-alpha", "gene_name": "Raet1a", "organism": "Mouse", "refseq_name": "retinoic acid early-inducible protein 1-alpha precursor", "refseq_ac": [ { "id": "NP_033042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033042", "type": "external" } ], "gene_names_uniprotkb": "Raet1a", "gene_names_refseq": "RAE-1alpha; Rae1alpha; Rae1a; Raet1a; Raet1", "protein_names_uniprotkb": "Retinoic acid early-inducible protein 1-alpha; RAE-1-alpha", "protein_names_refseq": "RAE-1-alpha; retinoic acid early-inducible protein 1-alpha precursor; retinoic acid early-inducible protein 1-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:19368)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10894171;20166740;21046555;25428506;8882725;8982867", "class_list": "", "function": "Acts as a ligand for KLRK1., [UniProtKB, PubMed]; These results reveal an unexpected role of RAE-1 in regulating adult SVZ neurogenesis by supporting stem/progenitor cells proliferation., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B9EI05", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0071222 cellular response to lipopolysaccharide;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08602-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08603-1", "uniprot_id": [ { "id": "RAE1B_MOUSE", "url": "https://www.uniprot.org/uniprot/O08603", "type": "external" } ], "mass": 28625.0, "length": 253, "protein_name": "Retinoic acid early-inducible protein 1-beta", "gene_name": "Raet1b", "organism": "Mouse", "refseq_name": "retinoic acid early-inducible protein 1-beta precursor", "refseq_ac": [ { "id": "NP_033043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033043", "type": "external" } ], "gene_names_uniprotkb": "Raet1b", "gene_names_refseq": "RAE-1beta; Rae1b; Raet1b", "protein_names_uniprotkb": "Retinoic acid early-inducible protein 1-beta; RAE-1-beta", "protein_names_refseq": "RAE-1-beta; Rae-1 beta; retinoic acid early-inducible protein 1-beta precursor; retinoic acid early-inducible protein 1-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:19369)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10894171;11248803;11557981;11825567;11857333;20166740;8882725;8982867", "class_list": "", "function": "Acts as a ligand for KLRK1., [UniProtKB, PubMed, PubMed, PubMed]; RAE-1B6 and H60 display high affinities for NKG2D with K(D) in the 20-30 nM range and k(off )in the 0.03s(-1) to 0.06s(-1) range (t(1/2) approximately 10-20s). They bind NKG2D with similar kinetics while sharing only 20% amino acid sequence identity., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2RS95", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0043032 positive regulation of macrophage activation;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08603-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08604-1", "uniprot_id": [ { "id": "RAE1C_MOUSE", "url": "https://www.uniprot.org/uniprot/O08604", "type": "external" } ], "mass": 28508.0, "length": 253, "protein_name": "Retinoic acid early-inducible protein 1-gamma", "gene_name": "Raet1c", "organism": "Mouse", "refseq_name": "retinoic acid early-inducible protein 1-gamma precursor", "refseq_ac": [ { "id": "NP_033044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033044", "type": "external" } ], "gene_names_uniprotkb": "Raet1c", "gene_names_refseq": "RAE-1gamma; Rae1c; Raet1c", "protein_names_uniprotkb": "Retinoic acid early-inducible protein 1-gamma; RAE-1-gamma", "protein_names_refseq": "RAE-1-gamma; retinoic acid early-inducible protein 1-gamma precursor; retinoic acid early-inducible protein 1-gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:19370)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10894171;20166740;23169621;24052528;34085696;8882725;8982867", "class_list": "", "function": "Acts as a ligand for KLRK1., [UniProtKB, PubMed]; The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1gamma by intracellular retention and cell surface masking., [RefSeq, PubMed]; Vectors expressing RAE-1gamma represent a promising approach in the development of CD8 T-cell-based vaccines., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2RSA1", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0071222 cellular response to lipopolysaccharide;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08604-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08674-1", "uniprot_id": [ { "id": "RBPJL_MOUSE", "url": "https://www.uniprot.org/uniprot/O08674", "type": "external" } ], "mass": 56780.0, "length": 515, "protein_name": "Recombining binding protein suppressor of hairless-like protein", "gene_name": "Rbpjl", "organism": "Mouse", "refseq_name": "recombining binding protein suppressor of hairless-like protein", "refseq_ac": [ { "id": "NP_033062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033062", "type": "external" } ], "gene_names_uniprotkb": "Rbpjl; Rbpl; Rbpsuhl", "gene_names_refseq": "RBP-L; Rbpjl; Rbpsuhl", "protein_names_uniprotkb": "Recombining binding protein suppressor of hairless-like protein; Transcription factor RBP-L", "protein_names_refseq": "RBP-J kappa-like; recombining binding protein suppressor of hairless-like protein; transcription factor RBP-L", "tax_id": 10090, "disease": "", "pathway": " (mmu:19668)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16354684;9111338", "class_list": "", "function": "Putative transcription factor, which cooperates with EBNA2 to activate transcription., [UniProtKB]; RBPJL is the third subunit of an unusual bHLH factor complex that binds and activates pancreatic acinar specific genes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08674-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35698-1", "uniprot_id": [ { "id": "RBMY_MOUSE", "url": "https://www.uniprot.org/uniprot/O35698", "type": "external" } ], "mass": 43216.0, "length": 380, "protein_name": "RNA-binding motif protein, Y chromosome", "gene_name": "Rbmy", "organism": "Mouse", "refseq_name": "RNA-binding motif protein, Y chromosome", "refseq_ac": [ { "id": "NP_001159856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159856", "type": "external" } ], "gene_names_uniprotkb": "Rbmy; Rbmy1a1; Rbm", "gene_names_refseq": "RBM; Rbm1-rs1; Rbm1; Rbmy1a1-rs1; Rbmy1a1; Rbmy1b; Rbmy", "protein_names_uniprotkb": "RNA-binding motif protein, Y chromosome; RNA-binding motif protein 1; RNA-binding motif protein, Y chromosome, family 1 member A1; Y chromosome RNA recognition motif 1", "protein_names_refseq": "RNA binding motif protein, Y chromosome, family 1, member A1, related sequence 1; RNA-binding motif protein 1; RNA-binding motif protein, Y chromosome, family 1 member A1; RNA-binding motif protein, Y chromosome, family 1 member B; RNA-binding motif protein, Y chromosome; y chromosome RNA recognition motif 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100862365); (mmu:100862394); (mmu:100862398); (mmu:19657)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10823932;12356914;15051956;9499427", "class_list": "", "function": "RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q856", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35698-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88451-1", "uniprot_id": [ { "id": "RDH7_MOUSE", "url": "https://www.uniprot.org/uniprot/O88451", "type": "external" } ], "mass": 35660.0, "length": 316, "protein_name": "Retinol dehydrogenase 7", "gene_name": "Rdh7", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 7", "refseq_ac": [ { "id": "NP_001144221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001144221", "type": "external" } ], "gene_names_uniprotkb": "Rdh7; Crad2", "gene_names_refseq": "CRAD2; Rdh7", "protein_names_uniprotkb": "Retinol dehydrogenase 7; 1.1.1.105; CRAD-2; Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2; Cis-retinol/androgen dehydrogenase type 2", "protein_names_refseq": "CRAD-2; cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2; cis-retinol/androgen dehydrogenase type 2; retinol dehydrogenase 7", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (mmu:54150)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10876094;34428180;37453647;9651397", "class_list": "", "function": "Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0003824 catalytic activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88451-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00796-1", "uniprot_id": [ { "id": "RENI2_MOUSE", "url": "https://www.uniprot.org/uniprot/P00796", "type": "external" } ], "mass": 44283.0, "length": 401, "protein_name": "Renin-2", "gene_name": "Ren2", "organism": "Mouse", "refseq_name": "renin-2 precursor", "refseq_ac": [ { "id": "NP_112470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112470", "type": "external" } ], "gene_names_uniprotkb": "Ren2; Ren-2", "gene_names_refseq": "Ren-2; Ren-B; Ren2; Ren; Rn-2; Rnr", "protein_names_uniprotkb": "Renin-2; 3.4.23.15; Angiotensinogenase; Submandibular gland renin", "protein_names_refseq": "angiotensinogenase; renin-2 precursor; renin-2; submandibular gland renin", "tax_id": 10090, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); atrial fibrillation (Disease Ontology:DOID:0060224); autosomal dominant tubulointerstitial kidney disease 4 (Disease Ontology:DOID:0061119); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); human cytomegalovirus infection (Disease Ontology:DOID:0080827); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hand, foot and mouth disease (Disease Ontology:DOID:10881); primary biliary cholangitis (Disease Ontology:DOID:12236); toxic shock syndrome (Disease Ontology:DOID:14115); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); acute kidney failure (Disease Ontology:DOID:3021); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic fatigue syndrome (Disease Ontology:DOID:8544); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19702)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1608447;2691339;32199017;32507043;6089205;6283373;6357783;6392850;6812055", "class_list": "", "function": "Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage., [RefSeq, PubMed]; Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney., [UniProtKB, UniProtKB]; Sex differences in blood pressure of aged Ren-2 transgenic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70229;P97955;Q62155", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005159 insulin-like growth factor receptor binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0045777 positive regulation of blood pressure;GO:0001822 kidney development;GO:0002003 angiotensin maturation;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00796-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06281-1", "uniprot_id": [ { "id": "RENI1_MOUSE", "url": "https://www.uniprot.org/uniprot/P06281", "type": "external" } ], "mass": 44343.0, "length": 402, "protein_name": "Renin-1", "gene_name": "Ren1", "organism": "Mouse", "refseq_name": "renin-1 precursor", "refseq_ac": [ { "id": "NP_112469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112469", "type": "external" } ], "gene_names_uniprotkb": "Ren1; Ren-1; Ren", "gene_names_refseq": "Ren-1; Ren-A; Ren1c; Ren1d; Ren1; Ren; Rn-1; Rnr", "protein_names_uniprotkb": "Renin-1; 3.4.23.15; Angiotensinogenase; Kidney renin", "protein_names_refseq": "angiotensinogenase; aspartyl-protease; kidney renin; renin b; renin-1 precursor; renin-1", "tax_id": 10090, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); atrial fibrillation (Disease Ontology:DOID:0060224); autosomal dominant tubulointerstitial kidney disease 4 (Disease Ontology:DOID:0061119); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); human cytomegalovirus infection (Disease Ontology:DOID:0080827); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hand, foot and mouth disease (Disease Ontology:DOID:10881); primary biliary cholangitis (Disease Ontology:DOID:12236); toxic shock syndrome (Disease Ontology:DOID:14115); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); acute kidney failure (Disease Ontology:DOID:3021); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic fatigue syndrome (Disease Ontology:DOID:8544); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19701); (R-MMU-2022377)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "2685761;2691339;6089205;6327270;6370686;6392850;9030738", "class_list": "", "function": "Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97911;Q543E5;Q62153;Q62154", "ec_number_list": [ { "id": "3.4.23.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005159 insulin-like growth factor receptor binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0032496 response to lipopolysaccharide;GO:0001822 kidney development;GO:0002003 angiotensin maturation;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06281-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22935-1", "uniprot_id": [ { "id": "RABP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P22935", "type": "external" } ], "mass": 15746.0, "length": 138, "protein_name": "Cellular retinoic acid-binding protein 2", "gene_name": "Crabp2", "organism": "Mouse", "refseq_name": "cellular retinoic acid-binding protein 2", "refseq_ac": [ { "id": "NP_031785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031785", "type": "external" } ], "gene_names_uniprotkb": "Crabp2", "gene_names_refseq": "Crabp-2; Crabp2; CrabpII", "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 2; CRABP-II; Cellular retinoic acid-binding protein II", "protein_names_refseq": "CRABP-II; cellular retinoic acid-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12904); (R-MMU-5362517)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10490651;1313808;2166951;34428180", "class_list": "", "function": "Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0001972 retinoic acid binding;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0042573 retinoic acid metabolic process;GO:0015908 fatty acid transport;GO:0035115 embryonic forelimb morphogenesis;GO:0048672 positive regulation of collateral sprouting", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22935-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54728-1", "uniprot_id": [ { "id": "RD23B_MOUSE", "url": "https://www.uniprot.org/uniprot/P54728", "type": "external" } ], "mass": 43513.0, "length": 416, "protein_name": "Lysine-specific demethylase RAD23B", "gene_name": "Rad23b", "organism": "Mouse", "refseq_name": "lysine-specific demethylase RAD23B", "refseq_ac": [ { "id": "NP_033037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033037", "type": "external" } ], "gene_names_uniprotkb": "Rad23b; Mhr23b", "gene_names_refseq": "0610007D13Rik; HR23B; Rad23b; mHR23B; p58", "protein_names_uniprotkb": "Lysine-specific demethylase RAD23B; 1.14.11.-; HR23B; UV excision repair protein RAD23 homolog B; XP-C repair-complementing complex 58 kDa protein; mHR23B; p58", "protein_names_refseq": "RAD23b homolog; UV excision repair protein RAD23 homolog B; XP-C repair-complementing complex 58 kDa protein; lysine-specific demethylase RAD23B", "tax_id": 10090, "disease": "", "pathway": " (mmu:19359); (R-MMU-532668); (R-MMU-5689877); (R-MMU-5696394); (R-MMU-5696395)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "11562482;11809813;12815074;15336624;15358861;16249333;16500903;16709668;22872234;26495903;26740625;26998601;31219806;33725478;34203471;34428180;39927985;40885482;40997131;8808275", "class_list": "", "function": "Data demonstrate that sequestration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, and a contributor to, poly(GA) pathology., [RefSeq, PubMed]; Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (PubMed:12815074, PubMed:15336624, PubMed:16709668). Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, a nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. Cooperatively with CETN2 appears to stabilize XPC (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUA4", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P54728-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58873-1", "uniprot_id": [ { "id": "RHBL3_MOUSE", "url": "https://www.uniprot.org/uniprot/P58873", "type": "external" } ], "mass": 45266.0, "length": 404, "protein_name": "Rhomboid-related protein 3", "gene_name": "Rhbdl3", "organism": "Mouse", "refseq_name": "rhomboid-related protein 3 isoform 2", "refseq_ac": [ { "id": "NP_631974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631974", "type": "external" } ], "gene_names_uniprotkb": "Rhbdl3; Rhbdl4; Vrho", "gene_names_refseq": "Rhbdl3; Rhbdl4; Rhomr1; Vrho", "protein_names_uniprotkb": "Rhomboid-related protein 3; 3.4.21.105; Ventrhoid transmembrane protein", "protein_names_refseq": "rhomboid protease 3; rhomboid related gene 1; rhomboid, veinlet-like 3; rhomboid, veinlet-like 4; rhomboid-related protein 3 isoform 2; rhomboid-related protein 3; ventrhoid transmembrane protein", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:246104)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11900977;38453906", "class_list": "", "function": "Cloning and expression of Ventrhoid, [RefSeq, PubMed]; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors., [UniProtKB]; RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58873-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82343-1", "uniprot_id": [ { "id": "RENBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P82343", "type": "external" } ], "mass": 48510.0, "length": 419, "protein_name": "N-acylglucosamine 2-epimerase", "gene_name": "Renbp", "organism": "Mouse", "refseq_name": "N-acylglucosamine 2-epimerase isoform 2", "refseq_ac": [ { "id": "NP_001158176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158176", "type": "external" } ], "gene_names_uniprotkb": "Renbp", "gene_names_refseq": "Age; Renbp; Rnbp", "protein_names_uniprotkb": "N-acylglucosamine 2-epimerase; 5.1.3.8; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP", "protein_names_refseq": "GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; N-acylglucosamine 2-epimerase isoform 2; N-acylglucosamine 2-epimerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:19703); (R-MMU-446210)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;22299025;22692205;25428506;30059200", "class_list": "glycogene", "function": "Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205)., [UniProtKB, PubMed]; Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIZ6;Q3UJ23;Q80Z67;Q91WI9;Q9CXI1", "ec_number_list": [ { "id": "5.1.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.8", "type": "external" } ], "go_molecular_function": "GO:0050121 N-acylglucosamine 2-epimerase activity;GO:0004857 enzyme inhibitor activity;GO:0005524 ATP binding;GO:0030414 peptidase inhibitor activity;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0043086 negative regulation of catalytic activity;GO:0010951 negative regulation of endopeptidase activity;GO:0006051 N-acetylmannosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P82343-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05186-1", "uniprot_id": [ { "id": "RCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05186", "type": "external" } ], "mass": 38113.0, "length": 325, "protein_name": "Reticulocalbin-1", "gene_name": "Rcn1", "organism": "Mouse", "refseq_name": "reticulocalbin-1 precursor", "refseq_ac": [ { "id": "NP_033063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033063", "type": "external" } ], "gene_names_uniprotkb": "Rcn1; Rca1; Rcn", "gene_names_refseq": "Rcn1; Rcn", "protein_names_uniprotkb": "Reticulocalbin-1", "protein_names_refseq": "reticulocalbin-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:19672); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;30899004;37746742;40885482;7523108;8416973;8537305", "class_list": "", "function": "Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells., [RefSeq, PubMed]; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVU3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q05186-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08652-1", "uniprot_id": [ { "id": "RET2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08652", "type": "external" } ], "mass": 15610.0, "length": 134, "protein_name": "Retinol-binding protein 2", "gene_name": "Rbp2", "organism": "Mouse", "refseq_name": "retinol-binding protein 2", "refseq_ac": [ { "id": "NP_033060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033060", "type": "external" } ], "gene_names_uniprotkb": "Rbp2; Crbpii", "gene_names_refseq": "Crbp-2; CrbpII; Rbp-2; Rbp2", "protein_names_uniprotkb": "Retinol-binding protein 2; CRBP-II; Cellular retinol-binding protein II", "protein_names_refseq": "CRBP-II; cellular retinol-binding protein II; retinol-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19660); (R-MMU-975634)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "28874522;28970247;32195347;8288643", "class_list": "", "function": "Genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release, [RefSeq, PubMed]; Intracellular transport of retinol., [UniProtKB]; Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1N1", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0044325 transmembrane transporter binding;GO:0019841 retinol binding;GO:0008289 lipid binding;GO:0016918 retinal binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0098681 synaptic ribbon", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08652-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZ01-1", "uniprot_id": [ { "id": "RNPC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZ01", "type": "external" } ], "mass": 57972.0, "length": 514, "protein_name": "RNA-binding region-containing protein 3", "gene_name": "Rnpc3", "organism": "Mouse", "refseq_name": "RNA-binding region-containing protein 3 isoform a", "refseq_ac": [ { "id": "NP_001033785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033785", "type": "external" } ], "gene_names_uniprotkb": "Rnpc3; Kiaa1839; Rbm40", "gene_names_refseq": "2810441O16Rik; C030014B17Rik; Rnpc3", "protein_names_uniprotkb": "RNA-binding region-containing protein 3; RNA-binding motif protein 40; RNA-binding protein 40", "protein_names_refseq": "RNA-binding motif protein 40; RNA-binding protein 40; RNA-binding region-containing protein 3 isoform a; RNA-binding region-containing protein 3", "tax_id": 10090, "disease": "combined or isolated pituitary growth hormone deficiency 7 (Disease Ontology:DOID:0061016)", "pathway": " (mmu:67225); (R-MMU-72165)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;30254136", "class_list": "", "function": "Our study, using a novel conditional mouse model of Rnpc3 deficiency, establishes that U12-dependent splicing is not only important during development but is indispensable throughout life., [RefSeq, PubMed]; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTZ2;Q69Z94;Q80VS9;Q91YJ1;Q9CSC1", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030626 U12 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UZ01-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62172-1", "uniprot_id": [ { "id": "RBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62172", "type": "external" } ], "mass": 75043.0, "length": 648, "protein_name": "RalA-binding protein 1", "gene_name": "Ralbp1", "organism": "Mouse", "refseq_name": "ralA-binding protein 1", "refseq_ac": [ { "id": "NP_001185878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185878", "type": "external" } ], "gene_names_uniprotkb": "Ralbp1; Rip1", "gene_names_refseq": "RLIP76; Ralbp1; Rip1", "protein_names_uniprotkb": "RalA-binding protein 1; 7.6.2.2; 7.6.2.3; DNP-SG ATPase; Dinitrophenyl S-glutathione ATPase; Ral-interacting protein 1; RalBP1", "protein_names_refseq": "DNP-SG ATPase; Ral-interacting protein 1; dinitrophenyl S-glutathione ATPase; ralA-binding protein 1", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629); urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (mmu:19765); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10910768;17242355;19131326;19144319;21183079;21750661;25450693;26498519;29572430;32994544;34428180;34831336;8570186;9395447", "class_list": "", "function": "Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance., [UniProtKB, UniProtKB]; Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS., [RefSeq, PubMed]; Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:8570186). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity)., [UniProtKB, UniProtKB, PubMed]; RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; RLIP76 acts as a scaffold at recycling endosomes by binding activated R-Ras, recruiting ARNO to activate Arf6, thereby contributing to cell spreading and migration., [RefSeq, PubMed]; Rlip deficiency suppresses spontaneous malignancy in p53(-/-) mice., [RefSeq, PubMed]; The results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXH5;Q9CRE5", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0043547 positive regulation of GTPase activity;GO:0055085 transmembrane transport;GO:0007264 small GTPase-mediated signal transduction;GO:0032489 regulation of Cdc42 protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62172-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3B9-1", "uniprot_id": [ { "id": "RBFA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P3B9", "type": "external" } ], "mass": 39317.0, "length": 350, "protein_name": "Putative ribosome-binding factor A, mitochondrial", "gene_name": "Rbfa", "organism": "Mouse", "refseq_name": "putative ribosome-binding factor A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_954667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954667", "type": "external" } ], "gene_names_uniprotkb": "Rbfa", "gene_names_refseq": "1110032A13Rik; Rbfa", "protein_names_uniprotkb": "Putative ribosome-binding factor A, mitochondrial", "protein_names_refseq": "putative ribosome-binding factor A, mitochondrial precursor; putative ribosome-binding factor A, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68731)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006364 rRNA processing;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P3B9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Y5D8-1", "uniprot_id": [ { "id": "RHG10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Y5D8", "type": "external" } ], "mass": 89366.0, "length": 786, "protein_name": "Rho GTPase-activating protein 10", "gene_name": "Arhgap10", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 10 isoform 1", "refseq_ac": [ { "id": "NP_084389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389", "type": "external" } ], "gene_names_uniprotkb": "Arhgap10", "gene_names_refseq": "A930033B01Rik; Arhgap10; PS-GAP; PSGAP-m; PSGAP-s; PSGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 10; PH and SH3 domain-containing rhoGAP protein; PS-GAP; PSGAP; Rho-type GTPase-activating protein 10", "protein_names_refseq": "PH and SH3 domain-containing rhoGAP protein; rho GTPase-activating protein 10 isoform 1; rho GTPase-activating protein 10; rho-type GTPase-activating protein 10", "tax_id": 10090, "disease": "Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311)", "pathway": " (mmu:78514); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11238453;15471851;27010858;33482876;34428180", "class_list": "", "function": "ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11238453). Also converts Cdc42 to an inactive GDP-bound state (By similarity). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases (PubMed:11238453). Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (PubMed:15471851). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6Y5D6;Q6Y5D7;Q99MT3;Q99MT4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6Y5D8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNK1-1", "uniprot_id": [ { "id": "RFX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNK1", "type": "external" } ], "mass": 83371.0, "length": 735, "protein_name": "Transcription factor RFX4", "gene_name": "Rfx4", "organism": "Mouse", "refseq_name": "transcription factor RFX4 isoform 1", "refseq_ac": [ { "id": "NP_001020089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020089", "type": "external" } ], "gene_names_uniprotkb": "Rfx4", "gene_names_refseq": "4933412G19Rik; NYD-sp10; Rfx4", "protein_names_uniprotkb": "Transcription factor RFX4; Regulatory factor X 4", "protein_names_refseq": "regulatory factor X 4 protein; transcription factor RFX4 isoform 1; transcription factor RFX4; winged-helix transcription factor RFX4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71137)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12925582;14701801;16893423;18218630;29298325", "class_list": "", "function": "Data implicate the RFX4_v3 variant transcript as being crucial for early brain development, as well as for the genesis of the subcommissural organ., [RefSeq, PubMed]; Mouse regulatory factor X4 transcript is expressed in the suprachiasmatic nucleus and regulated by light, [RefSeq, PubMed]; Provide a novel conditional KO animal model in which to investigate the downstream genes directly and/or indirectly regulated by RFX4 isoform 1. This model could provide new insights into the pathogenesis of obstructive hydrocephalus and holoprosencephaly in humans, both relatively common and disabling birth defects Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. May be required for neural tube ciliogenesis during embryogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RS52;Q3V158;Q76KT2;Q8HWA6;Q9D453", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021696 cerebellar cortex morphogenesis;GO:0021516 dorsal spinal cord development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TNK1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQA3-1", "uniprot_id": [ { "id": "RDHE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQA3", "type": "external" } ], "mass": 34193.0, "length": 309, "protein_name": "Epidermal retinol dehydrogenase 2", "gene_name": "Sdr16c5", "organism": "Mouse", "refseq_name": "epidermal retinol dehydrogenase 2", "refseq_ac": [ { "id": "NP_871789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_871789", "type": "external" } ], "gene_names_uniprotkb": "Sdr16c5; Rdhe2; Scdr9", "gene_names_refseq": "Rdhe2; Scdr9; Sdr16c5", "protein_names_uniprotkb": "Epidermal retinol dehydrogenase 2; 1.1.1.105; EPHD-2; RDH-E2; Retinal short-chain dehydrogenase reductase 2; Short-chain dehydrogenase reductase 9; Short-chain dehydrogenase/reductase family 16C member 5; retSDR2", "protein_names_refseq": "EPHD-2; RDH-E2; epidermal retinal dehydrogenase 2; epidermal retinol dehydrogenase 2; retSDR2; retinal short chain dehydrogenase reductase (Rdhe2); retinal short chain dehydrogenase reductase 2; short chain dehydrogenase reductase 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:242285); (R-MMU-5365859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "25428506;31562240;37075844", "class_list": "", "function": "Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH., [UniProtKB, UniProtKB]; SDR16C5 and SDR16C6 enzymes are not critical for survival but are responsible for most of the retinol dehydrogenase activity in skin, essential for the regulation of the hair-follicle cycle, and required for the maintenance of both sebaceous and meibomian glands, [RefSeq, PubMed]; Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" } ], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042572 retinol metabolic process;GO:0042574 retinal metabolic process;GO:0045814 negative regulation of gene expression, epigenetic;GO:0043616 keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XA6-1", "uniprot_id": [ { "id": "REPS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XA6", "type": "external" } ], "mass": 70484.0, "length": 647, "protein_name": "RalBP1-associated Eps domain-containing protein 2", "gene_name": "Reps2", "organism": "Mouse", "refseq_name": "ralBP1-associated Eps domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_839987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839987", "type": "external" } ], "gene_names_uniprotkb": "Reps2; Pob1", "gene_names_refseq": "POB1; Reps2", "protein_names_uniprotkb": "RalBP1-associated Eps domain-containing protein 2; Partner of RalBP1; RalBP1-interacting protein 2", "protein_names_refseq": "partner of RalBP1; ralBP1-associated Eps domain-containing protein 2 isoform 1; ralBP1-associated Eps domain-containing protein 2; ralBP1-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:194590); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12149250;17242355;31219806;40885482", "class_list": "", "function": "Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (By similarity). By controlling growth factor receptors endocytosis may regulate cell survival (By similarity). Through ASAP1 may regulate cell adhesion and migration (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AFI8", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80XA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHC7-1", "uniprot_id": [ { "id": "RHBL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHC7", "type": "external" } ], "mass": 35776.0, "length": 315, "protein_name": "Rhomboid-related protein 4", "gene_name": "Rhbdd1", "organism": "Mouse", "refseq_name": "rhomboid-related protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001116157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116157", "type": "external" } ], "gene_names_uniprotkb": "Rhbdd1; MSD-50; MSD50; Rhbdl4", "gene_names_refseq": "4930418P06Rik; RRP4; Rhbdd1; mRHBDD1", "protein_names_uniprotkb": "Rhomboid-related protein 4; 3.4.21.105; RRP4; Rhomboid domain-containing protein 1; Rhomboid-like protein 4; mRHBDD1", "protein_names_refseq": "rhomboid domain-containing protein 1; rhomboid-like protein 4; rhomboid-related protein 4 isoform 1; rhomboid-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:76867)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19358743;22795130;36825753", "class_list": "", "function": "Findings suggest that mRHBDD1 may be associated with mammalian spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia., [UniProtKB, PubMed, PubMed]; MiR-5195-3p functions as a tumor suppressor by targeting RHBDD1 in ovarian cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99K13;Q9D5L8", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol;GO:0043066 negative regulation of apoptotic process;GO:0043687 post-translational protein modification;GO:0006915 apoptotic process;GO:0010954 positive regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BHC7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHS3-1", "uniprot_id": [ { "id": "RBM22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHS3", "type": "external" } ], "mass": 46896.0, "length": 420, "protein_name": "Pre-mRNA-splicing factor RBM22", "gene_name": "Rbm22", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor RBM22", "refseq_ac": [ { "id": "NP_080052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080052", "type": "external" } ], "gene_names_uniprotkb": "Rbm22", "gene_names_refseq": "8430430L24Rik; Rbm22", "protein_names_uniprotkb": "Pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22", "protein_names_refseq": "pre-mRNA-splicing factor RBM22", "tax_id": 10090, "disease": "", "pathway": " (mmu:66810); (R-MMU-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23806337;31219806", "class_list": "", "function": "Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJB0;Q9CXA0", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0046827 positive regulation of protein export from nucleus;GO:0071466 cellular response to xenobiotic stimulus;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BL43-1", "uniprot_id": [ { "id": "RASFA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BL43", "type": "external" } ], "mass": 57333.0, "length": 508, "protein_name": "Ras association domain-containing protein 10", "gene_name": "Rassf10", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 10", "refseq_ac": [ { "id": "NP_780488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780488", "type": "external" } ], "gene_names_uniprotkb": "Rassf10", "gene_names_refseq": "4632411J06Rik; Rassf10", "protein_names_uniprotkb": "Ras association domain-containing protein 10", "protein_names_refseq": "ras association domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:78748)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29490266;32047266;32423821", "class_list": "", "function": "Plays an important role in regulating embryonic neurogenesis., [UniProtKB, PubMed]; RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice., [RefSeq, PubMed]; RASSF10 regulates bone invasion of growth hormone-secreting adenomas via exosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05AF4;Q8C0D3;Q8K340", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BL43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQC8-1", "uniprot_id": [ { "id": "RBAK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQC8", "type": "external" } ], "mass": 81675.0, "length": 711, "protein_name": "RB-associated KRAB zinc finger protein", "gene_name": "Rbak", "organism": "Mouse", "refseq_name": "RB-associated KRAB zinc finger protein", "refseq_ac": [ { "id": "NP_001038947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038947", "type": "external" } ], "gene_names_uniprotkb": "Rbak; Znf769", "gene_names_refseq": "Rbak", "protein_names_uniprotkb": "RB-associated KRAB zinc finger protein; RB-associated KRAB repressor; Zinc finger protein 769", "protein_names_refseq": "RB-associated KRAB repressor; RB-associated KRAB zinc finger protein; zinc finger protein 769", "tax_id": 10090, "disease": "", "pathway": " (mmu:57782)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10702291;31219806;34428180;36210013", "class_list": "", "function": "May repress E2F-dependent transcription. May promote AR-dependent transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PB38;Q9JKU4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BQC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUX5-1", "uniprot_id": [ { "id": "RHBG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUX5", "type": "external" } ], "mass": 49543.0, "length": 455, "protein_name": "Ammonium transporter Rh type B", "gene_name": "Rhbg", "organism": "Mouse", "refseq_name": "ammonium transporter Rh type B", "refseq_ac": [ { "id": "NP_067350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067350", "type": "external" } ], "gene_names_uniprotkb": "Rhbg", "gene_names_refseq": "Rhbg", "protein_names_uniprotkb": "Ammonium transporter Rh type B; Rh family type B glycoprotein; Rh type B glycoprotein; Rhesus blood group family type B glycoprotein", "protein_names_refseq": "Rh type B glycoprotein; ammonium transporter Rh type B; rh family type B glycoprotein; rhesus blood group family type B glycoprotein", "tax_id": 10090, "disease": "renal tubular acidosis (Disease Ontology:DOID:14219)", "pathway": " (mmu:58176); (R-MMU-444411)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11024028;12388412;12595489;12730882;15353405;15576624;16131648;20592240;26354748;27681563;39052834", "class_list": "", "function": "Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFkappaB., [RefSeq, PubMed]; Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (By similarity) (PubMed:15353405, PubMed:16131648, PubMed:20592240, PubMed:27681563). May act as a CO2 channel providing for renal acid secretion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Basolateral RhBG is expressed by perivenous hepatocytes, where it may mediate ammonium uptake, [RefSeq, PubMed]; Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney., [RefSeq, PubMed]; RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport., [RefSeq, PubMed]; Utilizing a structural homology analysis to AmtB, we have identified residues in Rhbg that are implicated in ion transport function. We introduced mutations into these residues and evaluated their function using measurements of intracellular pH (pHi), surface pH (pHs), and whole cell currents (I) that can distinguish between NH3 and NH4+ signals. Our results identified critical amino acids that affect transport., [RefSeq, PubMed]; We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+))., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXP1", "ec_number_list": [], "go_molecular_function": "GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0014731 spectrin-associated cytoskeleton", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0072488 ammonium transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BUX5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C7Q4-1", "uniprot_id": [ { "id": "RBM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7Q4", "type": "external" } ], "mass": 40046.0, "length": 361, "protein_name": "RNA-binding protein 4", "gene_name": "Rbm4", "organism": "Mouse", "refseq_name": "RNA-binding protein 4 isoform a", "refseq_ac": [ { "id": "NP_001277051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277051", "type": "external" } ], "gene_names_uniprotkb": "Rbm4; Rbm4a", "gene_names_refseq": "4921506I22Rik; Lark1; Mlark; Rbm4a; Rbm4; lark", "protein_names_uniprotkb": "RNA-binding protein 4; Lark homolog; RNA-binding motif protein 4a; RNA-binding motif protein 4; mLark", "protein_names_refseq": "RNA-binding motif protein 4a; RNA-binding protein 4 isoform a; RNA-binding protein 4; lark homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:19653)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16260624;17264215;19801630;21518792;21750661;25428506;34197715;34428180;37670183;37698901;9169144", "class_list": "", "function": "Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis., [RefSeq, PubMed]; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro., [UniProtKB, PubMed]; The N6-methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08752;Q8BN66", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0002190 cap-independent translational initiation;GO:0032055 negative regulation of translation in response to stress;GO:0006397 mRNA processing;GO:0046822 regulation of nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C7Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHD8-1", "uniprot_id": [ { "id": "RFIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHD8", "type": "external" } ], "mass": 118535.0, "length": 1047, "protein_name": "Rab11 family-interacting protein 3", "gene_name": "Rab11fip3", "organism": "Mouse", "refseq_name": "rab11 family-interacting protein 3 isoform b", "refseq_ac": [ { "id": "NP_001156340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156340", "type": "external" } ], "gene_names_uniprotkb": "Rab11fip3; Kiaa0665", "gene_names_refseq": "Cart1; D030060O14Rik; FIP3; Rab11-FIP3; Rab11fip3; mKIAA0665", "protein_names_uniprotkb": "Rab11 family-interacting protein 3; FIP3-Rab11; FIP3; Rab11-FIP3", "protein_names_refseq": "FIP3-Rab11; cytoplasmic adaptor for RAR and TR; rab11 family-interacting protein 3 isoform b; rab11 family-interacting protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:215445); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15601896;18685082;21183079;30295969;31219806;31970777;34428180", "class_list": "", "function": "Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:18685082). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex. The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle. Facilitates the interaction between dynein and dynactin and activates dynein processivity (By similarity). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (PubMed:18685082). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission. The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes. Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin. Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway. May play a role in breast cancer cell motility by regulating actin cytoskeleton (By similarity)., [UniProtKB, UniProtKB, PubMed]; FIP3 and FIP4 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation., [RefSeq, PubMed]; Fip3 and Rab11 protein complex regulates recycling endosomes targeting to the cleavage furrow during late cytokinesis., [RefSeq, PubMed]; IFN-gamma/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZT3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:0070164 negative regulation of adiponectin secretion;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0051301 cell division;GO:0060627 regulation of vesicle-mediated transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CHD8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHP5-1", "uniprot_id": [ { "id": "PYM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHP5", "type": "external" } ], "mass": 22690.0, "length": 203, "protein_name": "Partner of Y14 and mago", "gene_name": "Pym1", "organism": "Mouse", "refseq_name": "partner of Y14 and mago isoform 2", "refseq_ac": [ { "id": "NP_001164340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164340", "type": "external" } ], "gene_names_uniprotkb": "Pym1; Pym; Wibg", "gene_names_refseq": "A030010B05Rik; Pym1; Pym; Wibg", "protein_names_uniprotkb": "Partner of Y14 and mago; PYM homolog 1 exon junction complex-associated factor; Protein wibg homolog", "protein_names_refseq": "partner of Y14 and mago isoform 2; partner of Y14 and mago; protein wibg homolog; within bgcn homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78428)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12438415;21750661", "class_list": "", "function": "Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YD2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030054 cell junction", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:1903259 exon-exon junction complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CHP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K126-1", "uniprot_id": [ { "id": "RF1M_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K126", "type": "external" } ], "mass": 52458.0, "length": 446, "protein_name": "Peptide chain release factor 1, mitochondrial", "gene_name": "Mtrf1", "organism": "Mouse", "refseq_name": "peptide chain release factor 1, mitochondrial", "refseq_ac": [ { "id": "NP_666072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666072", "type": "external" } ], "gene_names_uniprotkb": "Mtrf1", "gene_names_refseq": "A830062K05Rik; MtRF-1; Mtrf1", "protein_names_uniprotkb": "Peptide chain release factor 1, mitochondrial; MRF-1; MtRF-1", "protein_names_refseq": "MRF-1; peptide chain release factor 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:211253); (R-MMU-5419276)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA. Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively. Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070126 mitochondrial translational termination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K126-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2P6-1", "uniprot_id": [ { "id": "RFESD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2P6", "type": "external" } ], "mass": 17966.0, "length": 157, "protein_name": "Rieske domain-containing protein", "gene_name": "Rfesd", "organism": "Mouse", "refseq_name": "Rieske domain-containing protein", "refseq_ac": [ { "id": "NP_001124540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124540", "type": "external" } ], "gene_names_uniprotkb": "Rfesd", "gene_names_refseq": "D030068K09; Rfesd", "protein_names_uniprotkb": "Rieske domain-containing protein", "protein_names_refseq": "Rieske domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:218341)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18703841;21238580", "class_list": "", "function": "Findings together provide novel evidence that mitochondria are the direct hypoxic targets in PASMCs, in which Rieske iron-sulfur protein in complex III may serve as an essential, primary molecule that mediates the hypoxic ROS generation, [RefSeq, PubMed]; Mouse Rieske-type ferredoxin was shown to be capable of accepting electrons from both eukaryotic and prokaryotic oxidoreductases, although it was unable to serve as an electron donor for a bacterial monooxygenase complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQH9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K2P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3C6-1", "uniprot_id": [ { "id": "RBM19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3C6", "type": "external" } ], "mass": 106083.0, "length": 952, "protein_name": "Probable RNA-binding protein 19", "gene_name": "Rbm19", "organism": "Mouse", "refseq_name": "probable RNA-binding protein 19", "refseq_ac": [ { "id": "NP_083038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083038", "type": "external" } ], "gene_names_uniprotkb": "Rbm19", "gene_names_refseq": "1200009A02Rik; NPO; Rbm19", "protein_names_uniprotkb": "Probable RNA-binding protein 19; RNA-binding motif protein 19", "protein_names_refseq": "probable RNA-binding protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:74111)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16027046;17242355;19087264;19144319;21750661;25428506;31219806;34887587", "class_list": "", "function": "Plays a role in embryo pre-implantation development., [UniProtKB, PubMed]; RBM19 is essential for preimplantation development, highlighting the importance of de novo nucleologenesis during this critical developmental stage. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHR0;Q9CW63", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0040019 positive regulation of embryonic development;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R3C6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC82-1", "uniprot_id": [ { "id": "RHBL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC82", "type": "external" } ], "mass": 41786.0, "length": 373, "protein_name": "Rhomboid-related protein 1", "gene_name": "Rhbdl1", "organism": "Mouse", "refseq_name": "rhomboid-related protein 1", "refseq_ac": [ { "id": "NP_659065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659065", "type": "external" } ], "gene_names_uniprotkb": "Rhbdl1; Rhbdl", "gene_names_refseq": "Rhbdl1; Rhbdl", "protein_names_uniprotkb": "Rhomboid-related protein 1; 3.4.21.105; RRP; Rhomboid-like protein 1", "protein_names_refseq": "RRP; rhomboid, veinlet-like 1; rhomboid-like protein 1; rhomboid-related protein 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:214951)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors., [UniProtKB, UniProtKB, UniProtKB]; Regulator of proteosome activity independent of enzymatic activity (By similarity). May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VC82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCH7-1", "uniprot_id": [ { "id": "RDH10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCH7", "type": "external" } ], "mass": 38075.0, "length": 341, "protein_name": "Retinol dehydrogenase 10", "gene_name": "Rdh10", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 10", "refseq_ac": [ { "id": "NP_598593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598593", "type": "external" } ], "gene_names_uniprotkb": "Rdh10", "gene_names_refseq": "3110069K09Rik; 4921506A21Rik; D1Ertd762e; Rdh10; m366Asp", "protein_names_uniprotkb": "Retinol dehydrogenase 10; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:98711); (R-MMU-2453902); (R-MMU-5365859)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12407145;15505029;17473173;34428180", "class_list": "", "function": "Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJ68", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060431 primary lung bud formation;GO:0043584 nose development;GO:0001701 in utero embryonic development;GO:0042572 retinol metabolic process;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W59-1", "uniprot_id": [ { "id": "RBMS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W59", "type": "external" } ], "mass": 43991.0, "length": 403, "protein_name": "RNA-binding motif, single-stranded-interacting protein 1", "gene_name": "Rbms1", "organism": "Mouse", "refseq_name": "RNA-binding motif, single-stranded-interacting protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001135403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135403", "type": "external" } ], "gene_names_uniprotkb": "Rbms1; Mssp1; Mssp", "gene_names_refseq": "2600014B10Rik; MSSP-1; MSSP-2; MSSP-3; Rbms1; YC1", "protein_names_uniprotkb": "RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA-binding protein MSSP-1", "protein_names_refseq": "RNA-binding motif, single-stranded-interacting protein 1 isoform 2; single-stranded DNA-binding protein MSSP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56878)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10639566;21750661;25428506;31219806;31599954;34428180;37511060;38288506", "class_list": "", "function": "CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status., [RefSeq, PubMed]; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication., [UniProtKB]; Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI25;Q3UXU2;Q6PEU6;Q6PHC2;Q9WTK4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91W59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J64-1", "uniprot_id": [ { "id": "RBM43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J64", "type": "external" } ], "mass": 38637.0, "length": 343, "protein_name": "RNA-binding protein 43", "gene_name": "Rbm43", "organism": "Mouse", "refseq_name": "RNA-binding protein 43 isoform b", "refseq_ac": [ { "id": "NP_001135453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135453", "type": "external" } ], "gene_names_uniprotkb": "Rbm43", "gene_names_refseq": "0610033I05Rik; Rbm43", "protein_names_uniprotkb": "RNA-binding protein 43; RNA-binding motif protein 43", "protein_names_refseq": "RNA-binding protein 43 isoform b; RNA-binding protein 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:71684)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99J64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KG3-1", "uniprot_id": [ { "id": "RBM10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KG3", "type": "external" } ], "mass": 103494.0, "length": 930, "protein_name": "RNA-binding protein 10", "gene_name": "Rbm10", "organism": "Mouse", "refseq_name": "RNA-binding protein 10 isoform 2", "refseq_ac": [ { "id": "NP_001161247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161247", "type": "external" } ], "gene_names_uniprotkb": "Rbm10; Kiaa0122", "gene_names_refseq": "E430039K10Rik; MINAS-60; Rbm10", "protein_names_uniprotkb": "RNA-binding protein 10; RNA-binding motif protein 10", "protein_names_refseq": "RNA-binding protein 10 isoform 2; RNA-binding protein 10; Ribosome biogenesis inhibitor MINAS-60", "tax_id": 10090, "disease": "TARP syndrome (Disease Ontology:DOID:0111780); lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:236732); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "15345747;17242355;18315527;18630941;19144319;21183079;24129315;29309623;31219806;34428180;36852467;36853175;40997131", "class_list": "", "function": "Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus., [UniProtKB, UniProtKB]; Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). May be involved in post-transcriptional processing, most probably in mRNA splicing (By similarity). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition., [RefSeq, PubMed]; S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II transcription, S1-1 nuclear bodies enlarge and decrease in number., [RefSeq, PubMed]; This study shows that Rbm10 regulates inflammation development via alternative splicing of Dnmt3b, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIY0;Q3U5B8;Q3UKI8;Q80U75;Q8BTP8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0048255 mRNA stabilization;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99KG3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P51-1", "uniprot_id": [ { "id": "RASF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P51", "type": "external" } ], "mass": 26749.0, "length": 232, "protein_name": "Ras association domain-containing protein 3", "gene_name": "Rassf3", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 3 isoform 1", "refseq_ac": [ { "id": "NP_620406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620406", "type": "external" } ], "gene_names_uniprotkb": "Rassf3", "gene_names_refseq": "Rassf3", "protein_names_uniprotkb": "Ras association domain-containing protein 3", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 3; Ras association domain family 3; novel ras effector 1; ras association domain-containing protein 3 isoform 1; ras association domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:192678)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11965544;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ17", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99P51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYN9-1", "uniprot_id": [ { "id": "RENR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYN9", "type": "external" } ], "mass": 39092.0, "length": 350, "protein_name": "Renin receptor", "gene_name": "Atp6ap2", "organism": "Mouse", "refseq_name": "renin receptor precursor", "refseq_ac": [ { "id": "NP_081715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081715", "type": "external" } ], "gene_names_uniprotkb": "Atp6ap2; Atp6ip2", "gene_names_refseq": "(P)RR; 5730403E06Rik; APT6M8-9; ATP6M8-9; Atp6ap2; Atp6ip2; M8-9; PRR", "protein_names_uniprotkb": "Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor", "protein_names_refseq": "ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal interacting protein 1; ATPase, H+ transporting, lysosomal interacting protein 2; renin receptor precursor; renin receptor; renin/prorenin receptor", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIr (Disease Ontology:DOID:0051048); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); X-linked parkinsonism-spasticity syndrome (Disease Ontology:DOID:0112105); hypertension (Disease Ontology:DOID:10763); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (mmu:70495); (R-MMU-2022377); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "18974301;25428506;25605945;26376863;26740625;29127204;30084848;30985297;31599954;34428180;35820727;39134597;39171392", "class_list": "", "function": "Collecting Duct Pro(Renin) Receptor Contributes to Unilateral Ureteral Obstruction-Induced Kidney Injury via Activation of the Intrarenal RAS., [RefSeq, PubMed]; Defined the role of (pro)renin receptor in choroidal neovascularization (CNV) generation;(Pro)renin receptor blockade suppressed ERK activation & the production of MCP-1 & VEGF, but not ICAM-1, VEGFR-1 or VEGFR-2, in AT1-R-deficient mice with CNV., [RefSeq, PubMed]; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (PubMed:26376863, PubMed:29127204, PubMed:30985297)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BDN5;Q8BVU6;Q91YU5", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005615 extracellular space;GO:0016020 membrane;GO:0030424 axon;GO:0005764 lysosome", "go_biological_process": "GO:0060323 head morphogenesis;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0021903 rostrocaudal neural tube patterning;GO:0002003 angiotensin maturation;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CYN9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7T1-1", "uniprot_id": [ { "id": "REP15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7T1", "type": "external" } ], "mass": 25854.0, "length": 230, "protein_name": "Rab15 effector protein", "gene_name": "Rep15", "organism": "Mouse", "refseq_name": "rab15 effector protein", "refseq_ac": [ { "id": "NP_079896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079896", "type": "external" } ], "gene_names_uniprotkb": "Rep15", "gene_names_refseq": "2210417D09Rik; Rep15", "protein_names_uniprotkb": "Rab15 effector protein", "protein_names_refseq": "rab15 effector protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66532)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Effector that interacts with Rab GTPases in their active form (GTP-bound) including RAB15, RAB3A-D and RAB34. Controls downstream signaling such as cell proliferation and cell migration. Also regulates transferrin receptor recycling from the endocytic recycling compartment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1M9;Q9D7R5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0001881 receptor recycling;GO:0033572 transferrin transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7T1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI20-1", "uniprot_id": [ { "id": "RED2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI20", "type": "external" } ], "mass": 82187.0, "length": 745, "protein_name": "Inactive double-stranded RNA-specific editase B2", "gene_name": "Adarb2", "organism": "Mouse", "refseq_name": "inactive double-stranded RNA-specific editase B2 isoform 1", "refseq_ac": [ { "id": "NP_443209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443209", "type": "external" } ], "gene_names_uniprotkb": "Adarb2; Adar3; Red2", "gene_names_refseq": "Adar3; Adarb2; RED2", "protein_names_uniprotkb": "Inactive double-stranded RNA-specific editase B2; RNA-dependent adenosine deaminase 3; RNA-editing deaminase 2; RNA-editing enzyme 2; dsRNA adenosine deaminase B2", "protein_names_refseq": "RNA dependent adenosine deaminase 3; RNA-editing deaminase 2; RNA-editing enzyme 2; adenosine deaminase 3, RNA dependent; double-stranded RNA-specific editase B2; dsRNA adenosine deaminase B2; inactive double-stranded RNA-specific editase B2 isoform 1; inactive double-stranded RNA-specific editase B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:94191)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10854777;34419568;34428180", "class_list": "glycogene", "function": "ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice. Erratum:[Gene. 2022 Feb 5;810:146107. doi: 10.1016/j.gene.2021.146107. PMID: 34872782], [RefSeq, PubMed]; Single- and double-stranded RNA-binding protein that interferes with the RNA editing activities of ADAR/ADAR1 and ADARB1/ADAR2. Likely competes with these proteins for target binding, repressing RNA editing across the transcriptome. Additionally, it binds and stabilizes specific mRNAs and regulates the expression of proteins such as MAVS, DUSP1, and EGR1, independently of RNA editing mechanisms., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTP1;Q8CC51;Q9JIE5", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0090367 negative regulation of mRNA modification;GO:0006382 adenosine to inosine editing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JI20-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJT0-1", "uniprot_id": [ { "id": "RCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJT0", "type": "external" } ], "mass": 40841.0, "length": 373, "protein_name": "RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "Rcl1", "organism": "Mouse", "refseq_name": "RNA 3'-terminal phosphate cyclase-like protein", "refseq_ac": [ { "id": "NP_067500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067500", "type": "external" } ], "gene_names_uniprotkb": "Rcl1; Rnac", "gene_names_refseq": "2310040A02Rik; RPCL1; Rcl1; Rnac", "protein_names_uniprotkb": "RNA 3'-terminal phosphate cyclase-like protein", "protein_names_refseq": "RNA 3'-terminal phosphate cyclase-like protein; RNA cyclase homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:59028); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10790377;19892989;21750661;25428506;27802388;30084848;30779550;31599954;34428180", "class_list": "", "function": "As part of the small subunit (SSU) processome, it plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). Activates BMS1 by promoting GDP/GTP exchange (By similarity). Does not have cyclase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004521 RNA endonuclease activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWZ1-1", "uniprot_id": [ { "id": "RAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWZ1", "type": "external" } ], "mass": 31610.0, "length": 280, "protein_name": "Cell cycle checkpoint protein RAD1", "gene_name": "Rad1", "organism": "Mouse", "refseq_name": "cell cycle checkpoint protein RAD1 isoform 1", "refseq_ac": [ { "id": "NP_001276376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276376", "type": "external" } ], "gene_names_uniprotkb": "Rad1; Rec1", "gene_names_refseq": "Rad1; mRAD1", "protein_names_uniprotkb": "Cell cycle checkpoint protein RAD1; Rad1-like DNA damage checkpoint protein; mRAD1", "protein_names_refseq": "DNA repair exonuclease rad1 homolog; RAD1 homolog; cell cycle checkpoint protein RAD1 isoform 1; cell cycle checkpoint protein RAD1; rad1-like DNA damage checkpoint protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19355); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "21750661;22517741;9660799;9705507;9716408;9828137;9878245", "class_list": "", "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70452;O88391;Q3TGU1;Q3UG66;Q9QWZ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0030896 checkpoint clamp complex;GO:0005634 nucleus", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0006281 DNA repair;GO:0071479 cellular response to ionizing radiation;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QWZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z129-1", "uniprot_id": [ { "id": "RECQ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z129", "type": "external" } ], "mass": 72484.0, "length": 648, "protein_name": "ATP-dependent DNA helicase Q1", "gene_name": "Recql", "organism": "Mouse", "refseq_name": "ATP-dependent DNA helicase Q1 isoform 3", "refseq_ac": [ { "id": "NP_001191836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191836", "type": "external" } ], "gene_names_uniprotkb": "Recql; Recql1", "gene_names_refseq": "RecQ1; Recql", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q1; 5.6.2.4; DNA 3'-5' helicase Q1; DNA-dependent ATPase Q1; RecQ protein-like 1", "protein_names_refseq": "ATP-dependent DNA helicase Q1 isoform 3; ATP-dependent DNA helicase Q1; DNA 3'-5' helicase Q1; DNA-dependent ATPase Q1; recQ protein-like 1", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19691)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17158923;21750661;31219806;34428180;9838113", "class_list": "", "function": "DNA helicase that plays a role in DNA damage repair and genome stability (By similarity). Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Plays a role in restoring regressed replication forks (By similarity). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (By similarity). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (By similarity)., [UniProtKB, UniProtKB]; DNA helicase that plays a role in DNA damage repair and genome stability. Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Plays a role in restoring regressed replication forks. Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions. May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens., [UniProtKB, UniProtKB]; Recql suppresses chromosomal instability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPI5;Q9Z128", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z129-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQN7-1", "uniprot_id": [ { "id": "RM41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQN7", "type": "external" } ], "mass": 15262.0, "length": 135, "protein_name": "Large ribosomal subunit protein mL41", "gene_name": "Mrpl41", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL41 precursor", "refseq_ac": [ { "id": "NP_001026978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978", "type": "external" } ], "gene_names_uniprotkb": "Mrpl41", "gene_names_refseq": "MRP-L27; Mrpl41; Rpml27", "protein_names_uniprotkb": "Large ribosomal subunit protein mL41; 39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41", "protein_names_refseq": "39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; large ribosomal subunit protein mL41 precursor; large ribosomal subunit protein mL41", "tax_id": 10090, "disease": "", "pathway": " (mmu:107733); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;31599954", "class_list": "", "function": "Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ44", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QGU6-1", "uniprot_id": [ { "id": "RTP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5QGU6", "type": "external" } ], "mass": 52220.0, "length": 474, "protein_name": "Receptor-transporting protein 3", "gene_name": "Rtp3", "organism": "Mouse", "refseq_name": "receptor-transporting protein 3", "refseq_ac": [ { "id": "NP_694740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694740", "type": "external" } ], "gene_names_uniprotkb": "Rtp3; Tmem7", "gene_names_refseq": "Rtp3; Tmem7", "protein_names_uniprotkb": "Receptor-transporting protein 3; Transmembrane protein 7", "protein_names_refseq": "receptor-transporting protein 3; transmembrane protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:235636)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12461651;15550249;21750661", "class_list": "", "function": "Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QP29;Q2KHT1;Q8VDC2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031849 olfactory receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0051205 protein insertion into membrane;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5QGU6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07091-1", "uniprot_id": [ { "id": "S10A4_MOUSE", "url": "https://www.uniprot.org/uniprot/P07091", "type": "external" } ], "mass": 11721.0, "length": 101, "protein_name": "Protein S100-A4", "gene_name": "S100a4", "organism": "Mouse", "refseq_name": "protein S100-A4", "refseq_ac": [ { "id": "NP_035441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035441", "type": "external" } ], "gene_names_uniprotkb": "S100a4; Capl; Mts1", "gene_names_refseq": "18A2; 42a; Capl; FSp1; Mts1; PeL98; S100a4; metastasin; pk9a", "protein_names_uniprotkb": "Protein S100-A4; Metastasin; Metastatic cell protein; PEL98; Placental calcium-binding protein; Protein 18A2; Protein Mts1; S100 calcium-binding protein A4", "protein_names_refseq": "Fibroblast-specific protein 1; calvasculin; metastatic cell protein; placental calcium-binding protein; protein 18A2; protein Mts1; protein S100-A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:20198)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "20103644;20519440;21540332;21750661;2332170;2550322;26495903;31219806;3162911;34428180;3628004;37828378;39025016;39241524;8051043;8423998", "class_list": "", "function": "Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:20519440). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:8051043). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (PubMed:8051043). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (PubMed:20103644). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; S100A4 promotes experimental autoimmune encephalomyelitis by impacting microglial inflammation through TLR4/NF-kappaB signaling pathway., [RefSeq, PubMed]; SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20066", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0003779 actin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P07091-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27048-1", "uniprot_id": [ { "id": "RSMB_MOUSE", "url": "https://www.uniprot.org/uniprot/P27048", "type": "external" } ], "mass": 23656.0, "length": 231, "protein_name": "Small nuclear ribonucleoprotein-associated protein B", "gene_name": "Snrpb", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein-associated protein B isoform 1", "refseq_ac": [ { "id": "NP_033251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033251", "type": "external" } ], "gene_names_uniprotkb": "Snrpb", "gene_names_refseq": "SM-B; SM11; SMB; SNRNP-B; Snrpb", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein B; Sm protein B; Sm-B; SmB; snRNP-B; snRPB", "protein_names_refseq": "sm protein B; small nuclear ribonucleoprotein-associated protein B isoform 1; small nuclear ribonucleoprotein-associated protein B", "tax_id": 10090, "disease": "cerebrocostomandibular syndrome (Disease Ontology:DOID:0111248); mixed connective tissue disease (Disease Ontology:DOID:3492); lung adenocarcinoma (Disease Ontology:DOID:3910); tauopathy (Disease Ontology:DOID:680)", "pathway": " (mmu:20638); (R-MMU-111367); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-73856); (R-MMU-77588); (R-MMU-9770562)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "1376292;19470752;21750661;24129315;28263986;33835288;35593225;36058892", "class_list": "", "function": "Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:28263986). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:19470752)., [UniProtKB, UniProtKB, PubMed, PubMed]; SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJT1", "ec_number_list": [], "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding;GO:0070990 snRNP binding;GO:0070034 telomerase RNA binding;GO:0071208 histone pre-mRNA DCP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006479 protein methylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27048-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T69-1", "uniprot_id": [ { "id": "RSBN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80T69", "type": "external" } ], "mass": 89251.0, "length": 795, "protein_name": "Lysine-specific demethylase 9", "gene_name": "Rsbn1", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 9 isoform 1", "refseq_ac": [ { "id": "NP_766272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766272", "type": "external" } ], "gene_names_uniprotkb": "Rsbn1; Kiaa3002; Rsbn", "gene_names_refseq": "C230004D03Rik; E330004N01; KDM9; Rosbin; Rsbn1; Rsbn; Rsbp; mKIAA3002", "protein_names_uniprotkb": "Lysine-specific demethylase 9; 1.14.11.-; KDM9; Rosbin; Round spermatid basic protein 1", "protein_names_refseq": "lysine-specific demethylase 9 isoform 1; lysine-specific demethylase 9; round spermatid basic protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229675)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14724137;20485683;21750661;28867287;31219806;33760197;34185806;34428180", "class_list": "", "function": "Comparative distributions of RSBN1 and methylated histone H4 Lysine 20 in the mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2) and trimethylated 'Lys-20' of histone H4 (H4K20me3) into monomethyl H4K20 (H4K20me1), thereby modulating chromosome architecture (PubMed:28867287, PubMed:34185806). May play a critical role in regulating H4K20 methylation during spermatogenesis (PubMed:28867287, PubMed:34185806)., [UniProtKB, PubMed, PubMed]; MicroRNA378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells., [RefSeq, PubMed]; Rosbin is associated with and is most likely phosphorylated by protein kinase A. We suggest that it plays an important role in transcriptional regulation in haploid germ cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0V3N6;B9EI66;Q3UUB5;Q4VC18;Q7TNJ3;Q8C2Z3", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80T69-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7N3-1", "uniprot_id": [ { "id": "RT09_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7N3", "type": "external" } ], "mass": 44929.0, "length": 390, "protein_name": "Small ribosomal subunit protein uS9m", "gene_name": "Mrps9", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS9m precursor", "refseq_ac": [ { "id": "NP_076003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076003", "type": "external" } ], "gene_names_uniprotkb": "Mrps9", "gene_names_refseq": "2310002A08Rik; Mrp-S9; Mrps9; S9mt; mg637", "protein_names_uniprotkb": "Small ribosomal subunit protein uS9m; 28S ribosomal protein S9, mitochondrial; MRP-S9; S9mt", "protein_names_refseq": "28S ribosomal protein S9, mitochondrial; muscle protein 637; small ribosomal subunit protein uS9m precursor; small ribosomal subunit protein uS9m", "tax_id": 10090, "disease": "", "pathway": " (mmu:69527); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;38381220", "class_list": "", "function": "MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AZ3;Q6IS29;Q80W17", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7N3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35427-1", "uniprot_id": [ { "id": "RPC9_MOUSE", "url": "https://www.uniprot.org/uniprot/O35427", "type": "external" } ], "mass": 16683.0, "length": 148, "protein_name": "DNA-directed RNA polymerase III subunit RPC9", "gene_name": "Crcp", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC9", "refseq_ac": [ { "id": "NP_031787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031787", "type": "external" } ], "gene_names_uniprotkb": "Crcp", "gene_names_refseq": "Crcp", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC9; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; Calcitonin gene-related peptide-receptor component protein; RNA polymerase III subunit C9", "protein_names_refseq": "CGRP-RCP; CGRP-receptor component protein; CGRPRCP; DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:12909); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10067875;10903324;12147211;21750661;22315449;24746422;34428180;35820727;38743922;9322931", "class_list": "", "function": "Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues., [UniProtKB, PubMed, UniProtKB, UniProtKB]; CGRP can inhibit microglia activation in vivo in EAE. CGRP and its receptor may represent novel protective factors in EAE., [RefSeq, PubMed]; CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling., [RefSeq, PubMed]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models. Publication Status: Online-Only, [RefSeq, PubMed]; The mouse cDNA for calcitonin receptor-like receptor (CRLR) was cloned. The signal transduction mechanism through the CGRP receptor was studied. mCRLR is a 462-amino acid G-protein-coupled heptahelical receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35427-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJZ4-1", "uniprot_id": [ { "id": "RT35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJZ4", "type": "external" } ], "mass": 35975.0, "length": 320, "protein_name": "Small ribosomal subunit protein mS35", "gene_name": "Mrps35", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS35 isoform 1", "refseq_ac": [ { "id": "NP_663548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663548", "type": "external" } ], "gene_names_uniprotkb": "Mrps35", "gene_names_refseq": "MDSO23; MRP-S28; MRPS28; Mrps35", "protein_names_uniprotkb": "Small ribosomal subunit protein mS35; 28S ribosomal protein S35, mitochondrial; MRP-S35; S35mt", "protein_names_refseq": "28S ribosomal protein S35, mitochondrial; MRP-S35; S35mt; mitochondrial ribosomal protein S34; small ribosomal subunit protein mS35 isoform 1; small ribosomal subunit protein mS35", "tax_id": 10090, "disease": "", "pathway": " (mmu:232536); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;31219806;31599954;37507081", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2KFS5;Q8VCG7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BJZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR08-1", "uniprot_id": [ { "id": "RPP29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR08", "type": "external" } ], "mass": 25637.0, "length": 221, "protein_name": "Ribonuclease P protein subunit p29", "gene_name": "Pop4", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p29", "refseq_ac": [ { "id": "NP_079666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079666", "type": "external" } ], "gene_names_uniprotkb": "Pop4; Rpp29", "gene_names_refseq": "1110023P21Rik; Pop4; Rpp29", "protein_names_uniprotkb": "Ribonuclease P protein subunit p29", "protein_names_refseq": "POP4 (processing of precursor, S. cerevisiae) homolog; ribonuclease P protein subunit p29", "tax_id": 10090, "disease": "", "pathway": " (mmu:66161)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18250455;20173027;21750661;25428506;25605945;30084848;30341086;30779550;34428180", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends., [UniProtKB, UniProtKB]; Two genes, Atp4a and Pop4, fulfilled the criteria from our candidate gene approaches. The knockdown of both genes in MIN6 cells led to decreased glucose-stimulated insulin secretion, indicating a regulatory role of both genes in insulin secretion, thereby possibly contributing to the phenotype linked to Nbg7p, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6V7", "ec_number_list": [], "go_molecular_function": "GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CR08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQL6-1", "uniprot_id": [ { "id": "RM35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQL6", "type": "external" } ], "mass": 21501.0, "length": 188, "protein_name": "Large ribosomal subunit protein bL35m", "gene_name": "Mrpl35", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL35m", "refseq_ac": [ { "id": "NP_079706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079706", "type": "external" } ], "gene_names_uniprotkb": "Mrpl35", "gene_names_refseq": "1110066C01Rik; Mrpl35", "protein_names_uniprotkb": "Large ribosomal subunit protein bL35m; 39S ribosomal protein L35, mitochondrial; L35mt; MRP-L35", "protein_names_refseq": "39S ribosomal protein L35, mitochondrial; L35mt; MRP-L35; large ribosomal subunit protein bL35m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66223); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UV31-1", "uniprot_id": [ { "id": "RN223_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UV31", "type": "external" } ], "mass": 30532.0, "length": 285, "protein_name": "RING finger protein 223", "gene_name": "Rnf223", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnf223", "gene_names_refseq": "", "protein_names_uniprotkb": "RING finger protein 223", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100045778)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UV31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10833-1", "uniprot_id": [ { "id": "RRAS_MOUSE", "url": "https://www.uniprot.org/uniprot/P10833", "type": "external" } ], "mass": 23764.0, "length": 218, "protein_name": "Ras-related protein R-Ras", "gene_name": "Rras", "organism": "Mouse", "refseq_name": "ras-related protein R-Ras isoform 1", "refseq_ac": [ { "id": "NP_033127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033127", "type": "external" } ], "gene_names_uniprotkb": "Rras", "gene_names_refseq": "Rras1; Rras", "protein_names_uniprotkb": "Ras-related protein R-Ras; 3.6.5.2; p23", "protein_names_refseq": "Harvey rat sarcoma oncogene, subgroup R; p23; ras-related protein R-Ras isoform 1; ras-related protein R-Ras; related RAS viral (r-ras) oncogene", "tax_id": 10090, "disease": "Costello syndrome (Disease Ontology:DOID:0050469); RASopathy (Disease Ontology:DOID:0080690); urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (mmu:20130); (R-MMU-416550)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;3098437;34428180;35055164;37175621;37453647;37507081", "class_list": "", "function": "GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (By similarity). Regulates the organization of the actin cytoskeleton (By similarity). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (By similarity)., [UniProtKB, UniProtKB]; Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010595 positive regulation of endothelial cell migration;GO:0030336 negative regulation of cell migration;GO:0045766 positive regulation of angiogenesis;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P10833-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62071-1", "uniprot_id": [ { "id": "RRAS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P62071", "type": "external" } ], "mass": 23400.0, "length": 204, "protein_name": "Ras-related protein R-Ras2", "gene_name": "Rras2", "organism": "Mouse", "refseq_name": "ras-related protein R-Ras2", "refseq_ac": [ { "id": "NP_080122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080122", "type": "external" } ], "gene_names_uniprotkb": "Rras2", "gene_names_refseq": "2610016H24Rik; Rras2; TC21", "protein_names_uniprotkb": "Ras-related protein R-Ras2; 3.6.5.2", "protein_names_refseq": "ras-related protein R-Ras2; related RAS viral (r-ras) oncogene 2; related RAS viral (r-ras) oncogene homolog 2", "tax_id": 10090, "disease": "Costello syndrome (Disease Ontology:DOID:0050469); RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome 12 (Disease Ontology:DOID:0112170); urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (mmu:66922); (R-MMU-9696273)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11788587;14724565;16467383;17114649;19144319;21183079;21750661;22645316;34428180;34887587;35055164;35120522;35294890;37453647;37507081", "class_list": "", "function": "A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors., [RefSeq, PubMed]; Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras might favor cell migration and elongation of tubules, events that occur later in development., [RefSeq, PubMed]; GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (By similarity). Regulates craniofacial development (By similarity)., [UniProtKB, UniProtKB]; Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; PI3K, but not RalGDS, is an important mediator of cell proliferation by TC21., [RefSeq, PubMed]; R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System. Publication Status: Online-Only, [RefSeq, PubMed]; Role of TC21/R-Ras2 activation in the migration of neurofibromin-deficient Schwann cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17082;Q3TA79;Q8C5D1;Q9D0H6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0007265 Ras protein signal transduction;GO:0007163 establishment or maintenance of cell polarity;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P62071-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59470-1", "uniprot_id": [ { "id": "RPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P59470", "type": "external" } ], "mass": 127715.0, "length": 1133, "protein_name": "DNA-directed RNA polymerase III subunit RPC2", "gene_name": "Polr3b", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC2", "refseq_ac": [ { "id": "NP_081699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081699", "type": "external" } ], "gene_names_uniprotkb": "Polr3b", "gene_names_refseq": "2700078H01Rik; A330032P03Rik; C128; Polr3b; RPC2", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC2; 2.7.7.6; C128; DNA-directed RNA polymerase III 127.6 kDa polypeptide; DNA-directed RNA polymerase III subunit B; RNA polymerase III subunit C2", "protein_names_refseq": "DNA-directed RNA polymerase III 127.6 kDa polypeptide; DNA-directed RNA polymerase III subunit B; DNA-directed RNA polymerase III subunit RPC2; RNA polymerase III subunit C2; RNA polymerase III subunit RPC2 homolog", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 8 (Disease Ontology:DOID:0060797); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (mmu:70428); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21750661;25428506;25895500;31219806;31221184;38465473;40885482", "class_list": "", "function": "Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol III active center together with the largest subunit POLR3A/RPC1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB]; Missense mutations in Polr3a and Polr3b can variably impair mouse development and Pol III function. Publication Status: Online-Only, [RefSeq, PubMed]; Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan., [RefSeq, PubMed]; The Polr3b in the hippocampus in the prefrontal cortex of the DBA/2 J strain were up-regulated. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NVF3", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0071667 DNA/RNA hybrid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005666 RNA polymerase III complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0009303 rRNA transcription;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P59470-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52592-1", "uniprot_id": [ { "id": "S1PR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P52592", "type": "external" } ], "mass": 38829.0, "length": 352, "protein_name": "Sphingosine 1-phosphate receptor 2", "gene_name": "S1pr2", "organism": "Mouse", "refseq_name": "sphingosine 1-phosphate receptor 2", "refseq_ac": [ { "id": "NP_034463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034463", "type": "external" } ], "gene_names_uniprotkb": "S1pr2; Edg5; Gpcr13; Lpb2", "gene_names_refseq": "1100001A16Rik; Edg5; Gpcr13; H218; LPb2; S1P2; S1pr2", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 2; Endothelial differentiation G protein-coupled receptor 5; Lysophospholipid receptor B2; S1P receptor 2; S1P receptor Edg-5; S1P2; Sphingosine 1-phosphate receptor Edg-5", "protein_names_refseq": "G-protein coupled receptor 13; S1P receptor 2; S1P receptor Edg-5; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5; lysophospholipid receptor B2; sphingosine 1-phosphate receptor 2; sphingosine 1-phosphate receptor Edg-5; sphingosine-1-phosphate receptor S1P(2)", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); autosomal recessive nonsyndromic deafness 68 (Disease Ontology:DOID:0110519); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:14739); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11908758;19144319;19349973;19656770;21750661;31219806;34428180;35820727;36852467;38827741;38909407;8288218;9931453", "class_list": "", "function": "A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis., [RefSeq, PubMed]; Enhanced EDG5 signaling plays an important role in the proliferation of kidney mesangial cells and the progression of immunoglobulin A nephropathy., [RefSeq, PubMed]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (By similarity). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (By similarity). Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche., [UniProtKB, UniProtKB, UniProtKB]; S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3Q7;Q9R236", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0001664 G protein-coupled receptor binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0046847 filopodium assembly;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P52592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPV3-1", "uniprot_id": [ { "id": "RM42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPV3", "type": "external" } ], "mass": 16493.0, "length": 142, "protein_name": "Large ribosomal subunit protein mL42", "gene_name": "Mrpl42", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL42 isoform 1 precursor", "refseq_ac": [ { "id": "NP_080341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080341", "type": "external" } ], "gene_names_uniprotkb": "Mrpl42; D10Ertd322e; Mrps32", "gene_names_refseq": "2700009F22Rik; 2900055D03Rik; D10Ertd322e; HSPC204; L31mt; L42mt; MRP-L31; MRP-L42; MRP-S32; Mrpl42; PTD007; Rpml31; S32mt", "protein_names_uniprotkb": "Large ribosomal subunit protein mL42; 28S ribosomal protein S32, mitochondrial; 39S ribosomal protein L31, mitochondrial; 39S ribosomal protein L42, mitochondrial; L31mt; L42mt; MRP-L31; MRP-L42; MRP-S32; S32mt", "protein_names_refseq": "28S ribosomal protein L42, mitochondrial; 28S ribosomal protein S32, mitochondrial; 39S ribosomal protein L31, mitochondrial; 39S ribosomal protein L42, mitochondrial; large ribosomal subunit protein mL42 isoform 1 precursor; large ribosomal subunit protein mL42; mitochndrial ribosomal protein L42", "tax_id": 10090, "disease": "", "pathway": " (mmu:67270); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CPV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A825-1", "uniprot_id": [ { "id": "CPLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A825", "type": "external" } ], "mass": 28422.0, "length": 258, "protein_name": "Ciliogenesis and planar polarity effector 2", "gene_name": "Cplane2", "organism": "Mouse", "refseq_name": "ciliogenesis and planar polarity effector 2", "refseq_ac": [ { "id": "NP_001074643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074643", "type": "external" } ], "gene_names_uniprotkb": "Cplane2; Gm723; Rsg1", "gene_names_refseq": "6330545A04Rik; Cplane2; Gm723; Rsg1; b2b2804Clo; b2b2827Clo", "protein_names_uniprotkb": "Ciliogenesis and planar polarity effector 2; REM2- and Rab-like small GTPase 1", "protein_names_refseq": "REM2 and RAB-like small GTPase 1; REM2- and Rab-like small GTPase 1; ciliogenesis and planar polarity effector 2; miro domain-containing protein C1orf89 homolog", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (mmu:76166)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29038301;35427153;38721990", "class_list": "", "function": "RSG1 is required for cilia-dependent neural tube closure., [RefSeq, PubMed]; RSG1 localizes to the mother centriole in a process that depends on tau tubulin kinase 2 (TTBK2), the CPLANE complex protein Inturned (INTU), and its own GTPase activity. The data suggest a specific role for RSG1 in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme., [RefSeq, PubMed]; Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0035869 ciliary transition zone", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0015031 protein transport;GO:0016485 protein processing;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2A825-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UU2-1", "uniprot_id": [ { "id": "RPP38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UU2", "type": "external" } ], "mass": 31129.0, "length": 280, "protein_name": "Ribonuclease P protein subunit p38", "gene_name": "Rpp38", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rpp38", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonuclease P protein subunit p38; RNaseP protein p38", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:227522); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTW5;Q8BU46", "ec_number_list": [], "go_molecular_function": "GO:0033204 ribonuclease P RNA binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80UU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE22-1", "uniprot_id": [ { "id": "RT23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE22", "type": "external" } ], "mass": 20348.0, "length": 177, "protein_name": "Small ribosomal subunit protein mS23", "gene_name": "Mrps23", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS23 isoform b", "refseq_ac": [ { "id": "NP_001278199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278199", "type": "external" } ], "gene_names_uniprotkb": "Mrps23", "gene_names_refseq": "D11Bwg1153e; MRP-S23; Mrps23; Rpms23; S23mt", "protein_names_uniprotkb": "Small ribosomal subunit protein mS23; 28S ribosomal protein S23, mitochondrial; MRP-S23; S23mt", "protein_names_refseq": "28S ribosomal protein S23, mitochondrial; small ribosomal subunit protein mS23 isoform b; small ribosomal subunit protein mS23", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 46 (Disease Ontology:DOID:0112115)", "pathway": " (mmu:64656); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;23806337;26495903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXH1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031965 nuclear membrane;GO:0005840 ribosome", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VE22-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RS91-1", "uniprot_id": [ { "id": "RRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RS91", "type": "external" } ], "mass": 74518.0, "length": 656, "protein_name": "RNA polymerase I-specific transcription initiation factor RRN3", "gene_name": "Rrn3", "organism": "Mouse", "refseq_name": "RNA polymerase I-specific transcription initiation factor RRN3", "refseq_ac": [ { "id": "NP_001034610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034610", "type": "external" } ], "gene_names_uniprotkb": "Rrn3", "gene_names_refseq": "E130302O19Rik; Rrn3; TIF-1A; Tif1a", "protein_names_uniprotkb": "RNA polymerase I-specific transcription initiation factor RRN3", "protein_names_refseq": "RNA polymerase I-specific transcription initiation factor RRN3; transcription initiation factor TIF-IA", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:106298); (R-MMU-73762); (R-MMU-73772)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "12015311;12620228;12646563;20484733;21183079;21952136;22872234;25428506;28715449;30084848;30779550;32152506;34203471;34428180;35820727;36210013;37828378", "class_list": "", "function": "Conditional deletion of the Rrn3 gene inhibits RNA polymerase I transcription but does not affect pre-initiation complex formation. Publication Status: Online-Only, [RefSeq, PubMed]; ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth., [RefSeq, PubMed]; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent pre-initiation complex (PIC)., [UniProtKB, PubMed, PubMed]; Rrn3 regulates rDNA transcription by determining the steady-state concentration of the Rrn3.RNA polymerase I complex within the nucleolus. (RRN3), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNE7;Q8K052", "ec_number_list": [], "go_molecular_function": "GO:0070063 RNA polymerase binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity;GO:0001042 RNA polymerase I core binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0007000 nucleolus organization;GO:0001701 in utero embryonic development;GO:0008283 cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "B2RS91-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62843-1", "uniprot_id": [ { "id": "RS15_MOUSE", "url": "https://www.uniprot.org/uniprot/P62843", "type": "external" } ], "mass": 17040.0, "length": 145, "protein_name": "Small ribosomal subunit protein uS19", "gene_name": "Rps15", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS19 isoform 1", "refseq_ac": [ { "id": "NP_033117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033117", "type": "external" } ], "gene_names_uniprotkb": "Rps15; Rig", "gene_names_refseq": "Rps15; rig", "protein_names_uniprotkb": "Small ribosomal subunit protein uS19; 40S ribosomal protein S15; RIG protein", "protein_names_refseq": "40S ribosomal protein S15; small ribosomal subunit protein uS19 isoform 1; small ribosomal subunit protein uS19", "tax_id": 10090, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040); insulinoma (Disease Ontology:DOID:3892)", "pathway": " (mmu:20054); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 12, "publication_id_list": "2154983;21750661;22872234;25428506;30084848;30779550;34428180;35820727;36210013;36288343;36517592;37453647", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11174;Q52KC9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0097371 MDM2/MDM4 family protein binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0097421 liver regeneration;GO:0006364 rRNA processing;GO:1901798 positive regulation of signal transduction by p53 class mediator;GO:0002181 cytoplasmic translation;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P62843-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56565-1", "uniprot_id": [ { "id": "S10A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P56565", "type": "external" } ], "mass": 10505.0, "length": 94, "protein_name": "Protein S100-A1", "gene_name": "S100a1", "organism": "Mouse", "refseq_name": "protein S100-A1", "refseq_ac": [ { "id": "NP_035439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035439", "type": "external" } ], "gene_names_uniprotkb": "S100a1", "gene_names_refseq": "S100a1; S100a; S100", "protein_names_uniprotkb": "Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1", "protein_names_refseq": "S-100 protein alpha chain; S-100 protein subunit alpha; protein S100-A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20193); (R-MMU-5686938)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11909974;16952982;17438143;21750661;3276520;35648290;38819384;9920416", "class_list": "", "function": "S100A1 expression characterizes terminally differentiated superficial cells in the urothelium of the murine bladder and ureter., [RefSeq, PubMed]; S100A1's single cysteine is an indispensable redox switch for the protection against diastolic calcium waves in cardiomyocytes., [RefSeq, PubMed]; Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:11909974, PubMed:16952982). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:17438143). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88949", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042311 vasodilation;GO:0008016 regulation of heart contraction;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56565-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YYI7-1", "uniprot_id": [ { "id": "RN217_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YYI7", "type": "external" } ], "mass": 56036.0, "length": 515, "protein_name": "E3 ubiquitin-protein ligase RNF217", "gene_name": "Rnf217", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF217", "refseq_ac": [ { "id": "NP_001139821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139821", "type": "external" } ], "gene_names_uniprotkb": "Rnf217; Ibrdc1", "gene_names_refseq": "Ibrdc1; Rnf217", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF217; 2.3.2.31; IBR domain-containing protein 1; RING finger protein 217", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF217; IBR domain containing 1; IBR domain-containing protein 1; probable E3 ubiquitin-protein ligase RNF217", "tax_id": 10090, "disease": "", "pathway": " (mmu:268291); (R-MMU-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "33895792", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis., [UniProtKB, PubMed]; RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YYI7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBB9-1", "uniprot_id": [ { "id": "RSAD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBB9", "type": "external" } ], "mass": 41524.0, "length": 362, "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "gene_name": "Rsad2", "organism": "Mouse", "refseq_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "refseq_ac": [ { "id": "NP_067359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067359", "type": "external" } ], "gene_names_uniprotkb": "Rsad2; Vig1", "gene_names_refseq": "2510004L01Rik; Rsad2; SAND; Vig1; cig5", "protein_names_uniprotkb": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; 4.2.-.-; Radical S-adenosyl methionine domain-containing protein 2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "protein_names_refseq": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; VHSV-induced-like protein; radical S-adenosyl methionine domain-containing protein 2; viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "tax_id": 10090, "disease": "respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273)", "pathway": " (mmu:58185)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11038379;11752458;15890971;16849320;17686841;19047684;19920176;21435586;21750661;21880757;22177558;28607080;34428180", "class_list": "", "function": "Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses (By similarity). Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity) (PubMed:17686841, PubMed:19047684, PubMed:21435586, PubMed:21880757)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Viperin is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5I6;Q3U5T4;Q3U622;Q3U627;Q3U7I6;Q3U7M1;Q3U8F4;Q3U8U7;Q3U941;Q3U977;Q3U9E1;Q3U9J0;Q3U9J3;Q3UBW6;Q3UC07;Q3UDI0;Q6PEU4;Q8VHM2;Q9JHD4", "ec_number_list": [ { "id": "4.2.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016829 lyase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0050709 negative regulation of protein secretion;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CBB9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6S7-1", "uniprot_id": [ { "id": "RRFM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6S7", "type": "external" } ], "mass": 29051.0, "length": 262, "protein_name": "Ribosome-recycling factor, mitochondrial", "gene_name": "Mrrf", "organism": "Mouse", "refseq_name": "ribosome-recycling factor, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080698", "type": "external" } ], "gene_names_uniprotkb": "Mrrf", "gene_names_refseq": "2400002D02Rik; MRFF; MTRRF; Mrrf; RRF", "protein_names_uniprotkb": "Ribosome-recycling factor, mitochondrial; RRF; Ribosome-releasing factor, mitochondrial", "protein_names_refseq": "ribosome-recycling factor, mitochondrial precursor; ribosome-recycling factor, mitochondrial; ribosome-releasing factor, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:67871); (R-MMU-5419276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;36210013", "class_list": "", "function": "Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with GFM2. Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1B055", "ec_number_list": [], "go_molecular_function": "GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D6S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1B9-1", "uniprot_id": [ { "id": "RM28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1B9", "type": "external" } ], "mass": 30170.0, "length": 257, "protein_name": "Large ribosomal subunit protein bL28m", "gene_name": "Mrpl28", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL28m", "refseq_ac": [ { "id": "NP_077189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077189", "type": "external" } ], "gene_names_uniprotkb": "Mrpl28", "gene_names_refseq": "1110015G04Rik; L28mt; MAAT1; MRP-L28; Mrpl28; p15", "protein_names_uniprotkb": "Large ribosomal subunit protein bL28m; 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28", "protein_names_refseq": "39S ribosomal protein L28, mitochondrial; large ribosomal subunit protein bL28m", "tax_id": 10090, "disease": "", "pathway": " (mmu:68611); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;33300544", "class_list": "", "function": "Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5Y0;Q3TR04;Q497Y8;Q66JU7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D1B9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TD16-1", "uniprot_id": [ { "id": "PACER_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TD16", "type": "external" } ], "mass": 72279.0, "length": 648, "protein_name": "Protein associated with UVRAG as autophagy enhancer", "gene_name": "Rubcnl", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rubcnl; 5031414D18Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein associated with UVRAG as autophagy enhancer; Pacer; Protein Rubicon-like", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19144319;21750661;30704899", "class_list": "", "function": "Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (By similarity). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (By similarity). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (PubMed:30704899). May act as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0061909 autophagosome-lysosome fusion;GO:0061910 autophagosome-endosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TD16-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NTA4-1", "uniprot_id": [ { "id": "RRAGB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NTA4", "type": "external" } ], "mass": 43191.0, "length": 374, "protein_name": "Ras-related GTP-binding protein B", "gene_name": "Rragb", "organism": "Mouse", "refseq_name": "ras-related GTP-binding protein B", "refseq_ac": [ { "id": "NP_001004154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004154", "type": "external" } ], "gene_names_uniprotkb": "Rragb", "gene_names_refseq": "Rragb", "protein_names_uniprotkb": "Ras-related GTP-binding protein B; 3.6.5.-; Rag B; RagB", "protein_names_refseq": "rag B; ragB; ras-related GTP-binding protein B", "tax_id": 10090, "disease": "ragopathy (Disease Ontology:DOID:0061140)", "pathway": " (mmu:245670); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21750661;24980141;25259925", "class_list": "", "function": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RagA and RagB are key regulators of lysosomal function and cardiac protection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVD6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0051020 GTPase binding;GO:0032561 guanyl ribonucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:1990131 Gtr1-Gtr2 GTPase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010507 negative regulation of autophagy;GO:0032008 positive regulation of TOR signaling;GO:0008104 intracellular protein localization;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NTA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62858-1", "uniprot_id": [ { "id": "RS28_MOUSE", "url": "https://www.uniprot.org/uniprot/P62858", "type": "external" } ], "mass": 7841.0, "length": 69, "protein_name": "Small ribosomal subunit protein eS28", "gene_name": "Rps28", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS28", "refseq_ac": [ { "id": "NP_058540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058540", "type": "external" } ], "gene_names_uniprotkb": "Rps28", "gene_names_refseq": "Rps28", "protein_names_uniprotkb": "Small ribosomal subunit protein eS28; 40S ribosomal protein S28", "protein_names_refseq": "40S ribosomal protein S28; small ribosomal subunit protein eS28", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (Disease Ontology:DOID:0111894)", "pathway": " (mmu:54127); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 6, "publication_id_list": "21750661;25605945;31219806;34428180;36517592;37453647", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25112;Q5BKQ7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62858-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E872-1", "uniprot_id": [ { "id": "RNPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E872", "type": "external" } ], "mass": 79535.0, "length": 720, "protein_name": "Aminopeptidase RNPEPL1", "gene_name": "Rnpepl1", "organism": "Mouse", "refseq_name": "aminopeptidase RNPEPL1", "refseq_ac": [ { "id": "NP_852070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852070", "type": "external" } ], "gene_names_uniprotkb": "Rnpepl1", "gene_names_refseq": "1110014H17Rik; Rnpepl1", "protein_names_uniprotkb": "Aminopeptidase RNPEPL1; 3.4.11.-; 3.4.11.18; Methionyl aminopeptidase", "protein_names_refseq": "aminopeptidase RNPEPL1; arginyl aminopeptidase-like 1; methionyl aminopeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:108657)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34203471", "class_list": "", "function": "Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity;GO:0008237 metallopeptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G5E872-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57784-1", "uniprot_id": [ { "id": "RU2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P57784", "type": "external" } ], "mass": 28357.0, "length": 255, "protein_name": "U2 small nuclear ribonucleoprotein A'", "gene_name": "Snrpa1", "organism": "Mouse", "refseq_name": "U2 small nuclear ribonucleoprotein A'", "refseq_ac": [ { "id": "NP_067311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067311", "type": "external" } ], "gene_names_uniprotkb": "Snrpa1", "gene_names_refseq": "1500015N06Rik; Snrpa1", "protein_names_uniprotkb": "U2 small nuclear ribonucleoprotein A'; U2 snRNP A'", "protein_names_refseq": "U2 small nuclear ribonucleoprotein A'; U2 snRNP A'", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); connective tissue disease (Disease Ontology:DOID:65)", "pathway": " (mmu:68981); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12036604;17242355;21750661;23806337;29187734;30084848;30779550;34428180;37507081", "class_list": "", "function": "Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development, [RefSeq, PubMed]; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7R8;Q8K2W4;Q91YW1;Q9JKQ3", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016604 nuclear body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P57784-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70577-1", "uniprot_id": [ { "id": "S22A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70577", "type": "external" } ], "mass": 61831.0, "length": 553, "protein_name": "Solute carrier family 22 member 2", "gene_name": "Slc22a2", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 2 isoform 1", "refseq_ac": [ { "id": "NP_038695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038695", "type": "external" } ], "gene_names_uniprotkb": "Slc22a2; Oct2", "gene_names_refseq": "Oct2; Orct2; Slc22a2; mOCT2", "protein_names_uniprotkb": "Solute carrier family 22 member 2; Organic cation transporter 2; mOCT2", "protein_names_refseq": "organic cation transporter 2; solute carrier family 22 member 2 isoform 1; solute carrier family 22 member 2", "tax_id": 10090, "disease": "kidney failure (Disease Ontology:DOID:1074); extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); hyperuricemia (Disease Ontology:DOID:1920); acute kidney failure (Disease Ontology:DOID:3021); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:20518); (R-MMU-112311); (R-MMU-181430); (R-MMU-2161517); (R-MMU-442660); (R-MMU-549127)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10051314;11845212;23458604;26979622;35820727;37511245;37775532;39145457", "class_list": "", "function": "Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:23458604). Functions as a Na(+)-independent, bidirectional uniporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (By similarity). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow. Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters. Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system. Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium. Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN). Mediates the uptake and efflux of choline (By similarity). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine (PubMed:23458604). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. Publication Status: Online-Only, [RefSeq, PubMed]; Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWF6;Q8K4X8", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0015870 acetylcholine transport;GO:0015695 organic cation transport;GO:0006812 monoatomic cation transport;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70577-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14131-1", "uniprot_id": [ { "id": "RS16_MOUSE", "url": "https://www.uniprot.org/uniprot/P14131", "type": "external" } ], "mass": 16445.0, "length": 146, "protein_name": "Small ribosomal subunit protein uS9", "gene_name": "Rps16", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS9", "refseq_ac": [ { "id": "NP_038675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038675", "type": "external" } ], "gene_names_uniprotkb": "Rps16", "gene_names_refseq": "Rps16", "protein_names_uniprotkb": "Small ribosomal subunit protein uS9; 40S ribosomal protein S16", "protein_names_refseq": "40S ribosomal protein S16; small ribosomal subunit protein uS9", "tax_id": 10090, "disease": "", "pathway": " (mmu:20055); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 12, "publication_id_list": "25605945;30084848;31219806;33300544;34428180;35820727;35984892;36517592;37453647;37507081;3915781;39627609", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THM9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P14131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31725-1", "uniprot_id": [ { "id": "S10A9_MOUSE", "url": "https://www.uniprot.org/uniprot/P31725", "type": "external" } ], "mass": 13049.0, "length": 113, "protein_name": "Protein S100-A9", "gene_name": "S100a9", "organism": "Mouse", "refseq_name": "protein S100-A9", "refseq_ac": [ { "id": "NP_001268781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268781", "type": "external" } ], "gene_names_uniprotkb": "S100a9; Cagb; Mrp14", "gene_names_refseq": "60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14; S100a9; p14", "protein_names_uniprotkb": "Protein S100-A9; Calgranulin-B; Leukocyte L1 complex heavy chain; MRP-14; Migration inhibitory factor-related protein 14; S100 calcium-binding protein A9; p14", "protein_names_refseq": "S100 calcium-binding protein A9; leukocyte L1 complex heavy chain; migration inhibitory factor-related protein 14; protein S100-A9", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); hepatocellular carcinoma (Disease Ontology:DOID:684); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:20202); (R-MMU-3000471); (R-MMU-5668599); (R-MMU-5686938); (R-MMU-6798695); (R-MMU-6799990)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "11169745;12529407;1373330;15331440;16452087;17767165;18403730;19402754;20213444;20523765;21382888;22804476;26740625;33563959;34562450;37015930;39337466;8645219", "class_list": "glycogene", "function": "Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds. Publication Status: Online-Only, [RefSeq, PubMed]; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed:15331440, PubMed:17767165, PubMed:18403730, PubMed:19402754, PubMed:22804476, PubMed:34562450). It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism (By similarity). Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions (By similarity). The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase (PubMed:15331440). Also participates in regulatory T-cell differentiation together with CD69 (By similarity). Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX (By similarity). The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities (PubMed:21382888). Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration (By similarity). Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER) (PubMed:17767165, PubMed:18403730, PubMed:19402754). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade (PubMed:17767165, PubMed:18403730, PubMed:19402754, PubMed:22804476). Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth (By similarity). Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3 (By similarity). Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK (By similarity). Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (By similarity). The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, NXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0006417 regulation of translation;GO:0010976 positive regulation of neuron projection development;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0034121 regulation of toll-like receptor signaling pathway;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P31725-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56183-1", "uniprot_id": [ { "id": "RRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P56183", "type": "external" } ], "mass": 54777.0, "length": 494, "protein_name": "Ribosomal RNA processing protein 1 homolog A", "gene_name": "Rrp1", "organism": "Mouse", "refseq_name": "ribosomal RNA processing protein 1 homolog A", "refseq_ac": [ { "id": "NP_035055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035055", "type": "external" } ], "gene_names_uniprotkb": "Rrp1; Nnp1", "gene_names_refseq": "NNP-1; Nnp1; Rrp1", "protein_names_uniprotkb": "Ribosomal RNA processing protein 1 homolog A; NNP-1; Novel nuclear protein 1; Nucleolar protein Nop52; RRP1-like protein", "protein_names_refseq": "RRP1-like protein; novel nuclear protein 1; nucleolar protein Nop52; protein NNP-1; ribosomal RNA processing 1 homolog; ribosomal RNA processing protein 1 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:18114)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;31219806;31599954;34428180;9192856", "class_list": "", "function": "Plays a critical role in the generation of 28S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35712;Q9ERE1;Q9JI07;Q9JK67;Q9JKU2", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56183-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62274-1", "uniprot_id": [ { "id": "RS29_MOUSE", "url": "https://www.uniprot.org/uniprot/P62274", "type": "external" } ], "mass": 6677.0, "length": 56, "protein_name": "Small ribosomal subunit protein uS14", "gene_name": "Rps29", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS14", "refseq_ac": [ { "id": "NP_033119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033119", "type": "external" } ], "gene_names_uniprotkb": "Rps29", "gene_names_refseq": "Rps29", "protein_names_uniprotkb": "Small ribosomal subunit protein uS14; 40S ribosomal protein S29", "protein_names_refseq": "40S ribosomal protein S29; S29 ribosomal protein; small ribosomal subunit protein uS14", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 13 (Disease Ontology:DOID:0111889)", "pathway": " (mmu:20090); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 11, "publication_id_list": "22872234;24129315;25605945;31219806;33649389;34428180;35820727;36517592;37453647;37828378;8781548", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P30054", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005840 ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P62274-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62754-1", "uniprot_id": [ { "id": "RS6_MOUSE", "url": "https://www.uniprot.org/uniprot/P62754", "type": "external" } ], "mass": 28681.0, "length": 249, "protein_name": "Small ribosomal subunit protein eS6", "gene_name": "Rps6", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS6", "refseq_ac": [ { "id": "NP_033122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033122", "type": "external" } ], "gene_names_uniprotkb": "Rps6", "gene_names_refseq": "Rps6; S6R", "protein_names_uniprotkb": "Small ribosomal subunit protein eS6; 40S ribosomal protein S6; Phosphoprotein NP33", "protein_names_refseq": "40S ribosomal protein S6; phosphoprotein NP33; small ribosomal subunit protein eS6", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:20104); (R-MMU-156827); (R-MMU-166208); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-9629569); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 15, "publication_count": 39, "publication_id_list": "10.1101/2023.09.13.557529;15809305;16140937;19376132;1939282;20126553;20179101;21183079;21814187;22796106;23806337;24557881;24836906;24838000;25229342;25605945;25762659;26563389;27237224;29187734;29894511;30044707;30084848;31219806;31517566;32487697;33649389;34428180;35820727;35984892;3601662;36210013;36288343;36517592;37453647;37507081;39627609;8440735;8917105", "class_list": "", "function": "Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P08227;P10660", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1903347 negative regulation of bicellular tight junction assembly;GO:0000278 mitotic cell cycle;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P62754-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62855-1", "uniprot_id": [ { "id": "RS26_MOUSE", "url": "https://www.uniprot.org/uniprot/P62855", "type": "external" } ], "mass": 13015.0, "length": 115, "protein_name": "Small ribosomal subunit protein eS26", "gene_name": "Rps26", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS26", "refseq_ac": [ { "id": "NP_038793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038793", "type": "external" } ], "gene_names_uniprotkb": "Rps26", "gene_names_refseq": "Rps26", "protein_names_uniprotkb": "Small ribosomal subunit protein eS26; 40S ribosomal protein S26", "protein_names_refseq": "40S ribosomal protein S26; small ribosomal subunit protein eS26", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 10 (Disease Ontology:DOID:0111888); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:27370); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;22872234;25428506;25605945;30084848;30451825;32152506;34428180;35820727;36517592;37453647;37507081;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Specific knockout of Rps26 in mouse oocytes resulted in retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes were arrested at the transition from the non-surrounded nucleolus (NSN) to surrounded nucleolus (SN)-type Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02383;P70394;Q06722", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0033119 negative regulation of RNA splicing;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P62855-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63084-1", "uniprot_id": [ { "id": "S10A5_MOUSE", "url": "https://www.uniprot.org/uniprot/P63084", "type": "external" } ], "mass": 10812.0, "length": 93, "protein_name": "Protein S100-A5", "gene_name": "S100a5", "organism": "Mouse", "refseq_name": "protein S100-A5", "refseq_ac": [ { "id": "NP_035442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035442", "type": "external" } ], "gene_names_uniprotkb": "S100a5; S100d", "gene_names_refseq": "S100D9; S100a5", "protein_names_uniprotkb": "Protein S100-A5; Protein S-100D; S100 calcium-binding protein A5", "protein_names_refseq": "protein S100-A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:20199)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24692514;9920416", "class_list": "", "function": "Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites (By similarity)., [UniProtKB]; S100a5 expression is directly and rapidly increased by odor stimulation of mouse olfactory sensory neurons. [S100a5], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88945;P82540", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043025 neuronal cell body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63084-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KG4-1", "uniprot_id": [ { "id": "RTL9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32KG4", "type": "external" } ], "mass": 138467.0, "length": 1339, "protein_name": "Retrotransposon Gag-like protein 9", "gene_name": "Rtl9", "organism": "Mouse", "refseq_name": "retrotransposon Gag-like protein 9", "refseq_ac": [ { "id": "NP_001035524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035524", "type": "external" } ], "gene_names_uniprotkb": "Rtl9; Gm385; Kiaa1318; Rgag1", "gene_names_refseq": "Gm385; Mar9; Mart9; Rgag1; Rtl9", "protein_names_uniprotkb": "Retrotransposon Gag-like protein 9; Retrotransposon gag domain-containing protein 1; Sushi-XF2", "protein_names_refseq": "retrotransposon Gag-like protein 9; retrotransposon gag domain containing 1; retrotransposon gag domain-containing protein 1; sushi-XF2", "tax_id": 10090, "disease": "", "pathway": " (mmu:209540)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16093683;16155747;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTY8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32KG4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TLD5-1", "uniprot_id": [ { "id": "RMP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TLD5", "type": "external" } ], "mass": 59084.0, "length": 531, "protein_name": "Unconventional prefoldin RPB5 interactor", "gene_name": "Uri1", "organism": "Mouse", "refseq_name": "unconventional prefoldin RPB5 interactor isoform a", "refseq_ac": [ { "id": "NP_035404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035404", "type": "external" } ], "gene_names_uniprotkb": "Uri1; Nnx3; Ppp1r19; Rmp; Uri", "gene_names_refseq": "NNX3; Rmp; Uri1", "protein_names_uniprotkb": "Unconventional prefoldin RPB5 interactor; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein", "protein_names_refseq": "RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; protein phosphatase 1 regulatory subunit 19; unconventional prefoldin RPB5 interactor isoform a; unconventional prefoldin RPB5 interactor", "tax_id": 10090, "disease": "", "pathway": " (mmu:19777)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;19144319;21750661;25428506;33205075;9878255", "class_list": "", "function": "Coxsackievirus B Type 4 Infection in beta Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region (By similarity)., [UniProtKB]; Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V078;Q8R5C4;Q9Z243", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0051219 phosphoprotein binding;GO:0019212 phosphatase inhibitor activity;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009615 response to virus;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TLD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYX8-1", "uniprot_id": [ { "id": "RUFY4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYX8", "type": "external" } ], "mass": 64036.0, "length": 563, "protein_name": "RUN and FYVE domain-containing protein 4", "gene_name": "Rufy4", "organism": "Mouse", "refseq_name": "RUN and FYVE domain-containing protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001029232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029232", "type": "external" } ], "gene_names_uniprotkb": "Rufy4", "gene_names_refseq": "F930048N03Rik; Rufy4", "protein_names_uniprotkb": "RUN and FYVE domain-containing protein 4", "protein_names_refseq": "RUN and FYVE domain-containing protein 4 isoform 2; RUN and FYVE domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:435626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26416964;38744829", "class_list": "", "function": "ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger (By similarity). Positive regulator of osteoclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes (PubMed:38744829)., [UniProtKB, UniProtKB, PubMed]; RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts. Publication Status: Online-Only, [RefSeq, PubMed]; RUFY4 is therefore the first molecule characterized to date that promotes autophagy and influences endosome dynamics in a subset of immune cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX43;D3YY30", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0005776 autophagosome;GO:0036019 endolysosome", "go_biological_process": "GO:0061763 multivesicular body-lysosome fusion;GO:0000045 autophagosome assembly;GO:0045780 positive regulation of bone resorption;GO:0016239 positive regulation of macroautophagy;GO:0071353 cellular response to interleukin-4", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TYX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TZX3-1", "uniprot_id": [ { "id": "S2533_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TZX3", "type": "external" } ], "mass": 35064.0, "length": 320, "protein_name": "Solute carrier family 25 member 33", "gene_name": "Slc25a33", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 33", "refseq_ac": [ { "id": "NP_081736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081736", "type": "external" } ], "gene_names_uniprotkb": "Slc25a33", "gene_names_refseq": "5730438N18Rik; Pnc1; Slc25a33", "protein_names_uniprotkb": "Solute carrier family 25 member 33", "protein_names_refseq": "novel mitochondrial carrier protein domains containing protein; solute carrier family 25 member 33", "tax_id": 10090, "disease": "familial hyperinsulinemic hypoglycemia 8 (Disease Ontology:DOID:0081328)", "pathway": " (mmu:70556)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17596519", "class_list": "", "function": "Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (By similarity). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity)., [UniProtKB, UniProtKB, PubMed]; The data indicate that PNC1 is a target of the IGF-I/mTOR pathway that is essential for mitochondrial activity in regulating cell growth and proliferation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921P8;Q9CYJ1", "ec_number_list": [], "go_molecular_function": "GO:0015218 pyrimidine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus;GO:0051881 regulation of mitochondrial membrane potential;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TZX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SUV1-1", "uniprot_id": [ { "id": "RSAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SUV1", "type": "external" } ], "mass": 48665.0, "length": 442, "protein_name": "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial", "gene_name": "Rsad1", "organism": "Mouse", "refseq_name": "radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001013399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013399", "type": "external" } ], "gene_names_uniprotkb": "Rsad1", "gene_names_refseq": "B430319G23; Rsad1", "protein_names_uniprotkb": "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; Putative heme chaperone", "protein_names_refseq": "oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1; putative heme chaperone; radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor; radical S-adenosyl methionine domain-containing protein 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:237926)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;34428180;36210013", "class_list": "", "function": "May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTE1;Q6PHM8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0020037 heme binding;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SUV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMB1-1", "uniprot_id": [ { "id": "RSLBA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IMB1", "type": "external" } ], "mass": 27067.0, "length": 242, "protein_name": "Ras-like protein family member 11A", "gene_name": "Rasl11a", "organism": "Mouse", "refseq_name": "ras-like protein family member 11A", "refseq_ac": [ { "id": "NP_081140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081140", "type": "external" } ], "gene_names_uniprotkb": "Rasl11a", "gene_names_refseq": "1110065D03Rik; Rasl11a", "protein_names_uniprotkb": "Ras-like protein family member 11A; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 11A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68895)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15033445;20168301;25605945;34428180", "class_list": "", "function": "In transient transfection experiments, RasL11a enhanced the transcriptional activity of an RNA polymerase I-specific reporter controlled by the rDNA enhancer/promoter region., [RefSeq, PubMed]; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148R6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IMB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5B0-1", "uniprot_id": [ { "id": "RRP12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5B0", "type": "external" } ], "mass": 143131.0, "length": 1295, "protein_name": "RRP12-like protein", "gene_name": "Rrp12", "organism": "Mouse", "refseq_name": "RRP12-like protein", "refseq_ac": [ { "id": "NP_955518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955518", "type": "external" } ], "gene_names_uniprotkb": "Rrp12; Kiaa0690", "gene_names_refseq": "Rrp12; mKIAA0690", "protein_names_uniprotkb": "RRP12-like protein", "protein_names_refseq": "RRP12-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:107094)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17242355;19144319;21183079;25605945;29187734;30084848;30779550;31219806;34428180;34887587", "class_list": "", "function": "Participates in the nucleoplasmic stage of pre-40S ribosomal subunit assembly, functioning as a scaffold for assembly factors and preparing pre-40S particles for export from the nucleus to the cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMI5;Q80TU2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6P5B0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76KJ5-1", "uniprot_id": [ { "id": "RPA34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q76KJ5", "type": "external" } ], "mass": 43082.0, "length": 399, "protein_name": "DNA-directed RNA polymerase I subunit RPA34", "gene_name": "Polr1g", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase I subunit RPA34", "refseq_ac": [ { "id": "NP_665821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665821", "type": "external" } ], "gene_names_uniprotkb": "Polr1g; Ase1; Cd3eap; Paf49", "gene_names_refseq": "1190028F09; 2610103M17Rik; ASE-1; Ase1; CAST; Cd3eap; PAF49; Polr1g", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA34; A34.5; DNA-directed RNA polymerase I subunit G; RNA polymerase I-associated factor PAF49", "protein_names_refseq": "A34.5; CD3 epsilon associated protein; CD3-epsilon-associated protein; CD3E antigen, epsilon polypeptide associated protein; CD3E-associated protein; DNA-directed RNA polymerase I subunit G; DNA-directed RNA polymerase I subunit RPA34; RNA polymerase I-associated factor PAF49; anti-sense to ERCC-1 protein; antisense to Ercc1", "tax_id": 10090, "disease": "multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:70333); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15226435;15345747;18329376;37356716", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Involved in UBTF-activated transcription, presumably at a step following PIC formation., [UniProtKB, PubMed]; PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53., [RefSeq, PubMed]; Serial deletion analysis revealed that amino acids 199-338 were necessary for the nucleolar localization of PAF49., [RefSeq, PubMed]; These results strongly suggest that RNA polymerase I (Pol I)-associated factor PAF49/ASE-1 plays an important role in rRNA transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0Y9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0009303 rRNA transcription;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76KJ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M732-1", "uniprot_id": [ { "id": "RTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M732", "type": "external" } ], "mass": 199048.0, "length": 1744, "protein_name": "Retrotransposon-like protein 1", "gene_name": "Rtl1", "organism": "Mouse", "refseq_name": "retrotransposon-like protein 1", "refseq_ac": [ { "id": "NP_908998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908998", "type": "external" } ], "gene_names_uniprotkb": "Rtl1; Mar1; Mart1; Peg11", "gene_names_refseq": "6430411K18Rik; Mart1; Mar; Mor1; Peg11; Rtl1", "protein_names_uniprotkb": "Retrotransposon-like protein 1; Mammalian retrotransposon derived protein 1; Paternally expressed gene 11 protein; Retrotransposon-derived protein PEG11", "protein_names_refseq": "mammalian retrotransposon derived protein 1; paternally expressed gene 11 protein; retrotransposon-derived protein PEG11; retrotransposon-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:353326)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12796779;12937418;16093683;17216273;17901046;18176565;30084848", "class_list": "", "function": "Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta., [UniProtKB, PubMed]; Rtl1, an imprinted gene with preferential expression from the paternal allele, is essential for maintenance of the fetal capillaries., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030018 Z disc", "go_biological_process": "GO:0001525 angiogenesis;GO:0001890 placenta development;GO:0001892 embryonic placenta development;GO:0007519 skeletal muscle tissue development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7M732-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X85-1", "uniprot_id": [ { "id": "RT07_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X85", "type": "external" } ], "mass": 28063.0, "length": 242, "protein_name": "Small ribosomal subunit protein uS7m", "gene_name": "Mrps7", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS7m precursor", "refseq_ac": [ { "id": "NP_079581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079581", "type": "external" } ], "gene_names_uniprotkb": "Mrps7", "gene_names_refseq": "MRP-S7; Mrps7; Rpms7; S7mt", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7m; 28S ribosomal protein S7, mitochondrial; MRP-S7; S7mt", "protein_names_refseq": "28S ribosomal protein S7, mitochondrial; ribosomal protein, mitochondrial, S7; small ribosomal subunit protein uS7m precursor; small ribosomal subunit protein uS7m", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 34 (Disease Ontology:DOID:0111497)", "pathway": " (mmu:50529); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "25605945;30084848;30779550;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSI9;Q9CV71", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80X85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X95-1", "uniprot_id": [ { "id": "RRAGA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X95", "type": "external" } ], "mass": 36566.0, "length": 313, "protein_name": "Ras-related GTP-binding protein A", "gene_name": "Rraga", "organism": "Mouse", "refseq_name": "ras-related GTP-binding protein A", "refseq_ac": [ { "id": "NP_848463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848463", "type": "external" } ], "gene_names_uniprotkb": "Rraga", "gene_names_refseq": "1300010C19Rik; FIP-1; RAGA; Rraga", "protein_names_uniprotkb": "Ras-related GTP-binding protein A; 3.6.5.-; Rag A; RagA", "protein_names_refseq": "rag A; ras-related GTP-binding protein A", "tax_id": 10090, "disease": "ragopathy (Disease Ontology:DOID:0061140)", "pathway": " (mmu:68441); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8866654); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "22442136;23263183;25259925;29644770;30084848", "class_list": "", "function": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:23263183). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:23263183). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:23263183). Involved in the RCC1/Ran-GTPase pathway (By similarity). May play a direct role in a TNF signaling pathway leading to induction of cell death (By similarity)., [UniProtKB, UniProtKB, PubMed]; Overexpression of constitutively active (ca)RagA and caRagC increased mTORC1 activity, as determined by increased S6K1 phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXR0;Q8C1S2;Q8CFU3", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0042268 regulation of cytolysis;GO:0000045 autophagosome assembly;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80X95-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y81-1", "uniprot_id": [ { "id": "RNZ2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y81", "type": "external" } ], "mass": 92719.0, "length": 831, "protein_name": "Zinc phosphodiesterase ELAC protein 2", "gene_name": "Elac2", "organism": "Mouse", "refseq_name": "zinc phosphodiesterase ELAC protein 2 isoform 1", "refseq_ac": [ { "id": "NP_075968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075968", "type": "external" } ], "gene_names_uniprotkb": "Elac2", "gene_names_refseq": "1110017O07Rik; D11Wsu80e; Elac2; Hpc2", "protein_names_uniprotkb": "Zinc phosphodiesterase ELAC protein 2; 3.1.26.11; ElaC homolog protein 2; RNase Z 2; Ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2", "protein_names_refseq": "RNase Z 2; elaC homolog 2; elaC homolog protein 2; putative prostate cancer susceptibility protein; ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2; tRNase Z(L); zinc phosphodiesterase ELAC protein 2 isoform 1; zinc phosphodiesterase ELAC protein 2", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 17 (Disease Ontology:DOID:0111496); infantile hypertrophic cardiomyopathy (Disease Ontology:DOID:0111753); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:68626)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11175785;17242355;17525332;19131326;21183079;21750661;30126926;31219806", "class_list": "", "function": "We show that ELAC2 is required for processing of tRNAs and for the balanced maintenance of C/D box snoRNAs, miRNAs, and a new class of tRNA fragments. We identify that correct biogenesis of regulatory non-coding RNAs is essential for both cytoplasmic and mitochondrial protein synthesis and the assembly of mitochondrial ribosomes and cytoplasmic polysomes., [RefSeq, PubMed]; Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ATP6;Q99MF0;Q99MF1;Q9CTA2;Q9D1A8;Q9EPZ2", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity;GO:0004549 tRNA-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0042780 tRNA 3'-end processing;GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80Y81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZI2-1", "uniprot_id": [ { "id": "RTP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZI2", "type": "external" } ], "mass": 25900.0, "length": 223, "protein_name": "Receptor-transporting protein 2", "gene_name": "Rtp2", "organism": "Mouse", "refseq_name": "receptor-transporting protein 2", "refseq_ac": [ { "id": "NP_001008231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008231", "type": "external" } ], "gene_names_uniprotkb": "Rtp2; Gm605", "gene_names_refseq": "Gm605; Rtp2", "protein_names_uniprotkb": "Receptor-transporting protein 2", "protein_names_refseq": "receptor-transporting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:224055)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15550249;21750661", "class_list": "", "function": "Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031849 olfactory receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0051205 protein insertion into membrane;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIV3-1", "uniprot_id": [ { "id": "RNBP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIV3", "type": "external" } ], "mass": 124587.0, "length": 1105, "protein_name": "Ran-binding protein 6", "gene_name": "Ranbp6", "organism": "Mouse", "refseq_name": "ran-binding protein 6", "refseq_ac": [ { "id": "NP_808389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808389", "type": "external" } ], "gene_names_uniprotkb": "Ranbp6", "gene_names_refseq": "C630001B19; Ranbp6", "protein_names_uniprotkb": "Ran-binding protein 6; RanBP6", "protein_names_refseq": "ran-binding protein 6", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:240614)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25428506;30084848;34428180", "class_list": "", "function": "May function in nuclear protein import as nuclear transport receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTJ6", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BIV3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ73-1", "uniprot_id": [ { "id": "RSPO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ73", "type": "external" } ], "mass": 25866.0, "length": 228, "protein_name": "R-spondin-4", "gene_name": "Rspo4", "organism": "Mouse", "refseq_name": "R-spondin-4 precursor", "refseq_ac": [ { "id": "NP_001035779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035779", "type": "external" } ], "gene_names_uniprotkb": "Rspo4", "gene_names_refseq": "A730099F22; A930029K19Rik; Rspo4", "protein_names_uniprotkb": "R-spondin-4; Cristin-4; Cysteine-rich and single thrombospondin domain-containing protein 4; Roof plate-specific spondin-4; mCristin-4", "protein_names_refseq": "R-spondin family, member 4; R-spondin-4 precursor; R-spondin-like protein; cristin-4; cysteine-rich and single thrombospondin domain-containing protein 4; mCristin-4; roof plate-specific spondin-4", "tax_id": 10090, "disease": "nonsyndromic congenital nail disorder 4 (Disease Ontology:DOID:0080082)", "pathway": " (mmu:228770); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21693646;32926477", "class_list": "", "function": "Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway., [UniProtKB, PubMed]; Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKalpha-SREBP2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035878 nail development;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BJ73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BK72-1", "uniprot_id": [ { "id": "RT27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BK72", "type": "external" } ], "mass": 47779.0, "length": 415, "protein_name": "Small ribosomal subunit protein mS27", "gene_name": "Mrps27", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS27", "refseq_ac": [ { "id": "NP_776118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776118", "type": "external" } ], "gene_names_uniprotkb": "Mrps27", "gene_names_refseq": "2610028H14Rik; Mrps27", "protein_names_uniprotkb": "Small ribosomal subunit protein mS27; 28S ribosomal protein S27, mitochondrial; MRP-S27; Mitochondrial ribosomal protein S27; S27mt", "protein_names_refseq": "28S ribosomal protein S27, mitochondrial; MRP-S27; S27mt; small ribosomal subunit protein mS27", "tax_id": 10090, "disease": "", "pathway": " (mmu:218506); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;31487196", "class_list": "", "function": "RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKZ5", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0008283 cell population proliferation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BK72-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZG5-1", "uniprot_id": [ { "id": "MT25B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZG5", "type": "external" } ], "mass": 53259.0, "length": 475, "protein_name": "Methyltransferase-like protein 25B", "gene_name": "Mettl25b", "organism": "Mouse", "refseq_name": "methyltransferase-like protein 25B", "refseq_ac": [ { "id": "NP_705790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705790", "type": "external" } ], "gene_names_uniprotkb": "Mettl25b; Rrnad1", "gene_names_refseq": "Mettl25b; Rrnad1", "protein_names_uniprotkb": "Methyltransferase-like protein 25B; Protein RRNAD1", "protein_names_refseq": "methyltransferase-like protein 25B; protein RRNAD1; ribosomal RNA adenine dimethylase domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229503)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X8Q8;Q8CII4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BZG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBB2-1", "uniprot_id": [ { "id": "S15A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBB2", "type": "external" } ], "mass": 62622.0, "length": 566, "protein_name": "Solute carrier family 15 member 5", "gene_name": "Slc15a5", "organism": "Mouse", "refseq_name": "solute carrier family 15 member 5", "refseq_ac": [ { "id": "NP_808455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808455", "type": "external" } ], "gene_names_uniprotkb": "Slc15a5", "gene_names_refseq": "9830102E05Rik; Slc15a5", "protein_names_uniprotkb": "Solute carrier family 15 member 5", "protein_names_refseq": "solute carrier family 15 member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:277898)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Proton oligopeptide cotransporter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUQ4", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0015833 peptide transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CBB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1Z9-1", "uniprot_id": [ { "id": "RN121_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1Z9", "type": "external" } ], "mass": 37987.0, "length": 327, "protein_name": "E3 ubiquitin ligase Rnf121", "gene_name": "Rnf121", "organism": "Mouse", "refseq_name": "E3 ubiquitin ligase Rnf121 isoform 1", "refseq_ac": [ { "id": "NP_083487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083487", "type": "external" } ], "gene_names_uniprotkb": "Rnf121", "gene_names_refseq": "4930544L10Rik; Rnf121", "protein_names_uniprotkb": "E3 ubiquitin ligase Rnf121; 2.3.2.27; RING finger protein 121", "protein_names_refseq": "E3 ubiquitin ligase Rnf121 isoform 1; E3 ubiquitin ligase Rnf121", "tax_id": 10090, "disease": "", "pathway": " (mmu:75212)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39402275", "class_list": "", "function": "E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity)., [UniProtKB, UniProtKB]; Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXH5;Q8BP06;Q8BSB1;Q9D4X4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R1Z9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4Y8-1", "uniprot_id": [ { "id": "RTTN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4Y8", "type": "external" } ], "mass": 248489.0, "length": 2226, "protein_name": "Rotatin", "gene_name": "Rttn", "organism": "Mouse", "refseq_name": "rotatin", "refseq_ac": [ { "id": "NP_780751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780751", "type": "external" } ], "gene_names_uniprotkb": "Rttn", "gene_names_refseq": "4921538A15Rik; C530033I08Rik; D230040K24; Rttn", "protein_names_uniprotkb": "Rotatin", "protein_names_refseq": "rotatin", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:246102)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11900971;17551791;21750661;30779550;31219806;34428180;35820727;36210013", "class_list": "", "function": "Cloning and characterization of rotatin, [RefSeq, PubMed]; Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2 (By similarity)., [UniProtKB]; No turning (nt), a recessive lethal mutation causing left-right and axial patterning defects is likely elicited by deficiency of Rttn on chromosome 18., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0PJL2;Q8BPW5;Q8C461;Q8CCK5;Q8CIG4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0016020 membrane;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007368 determination of left/right symmetry;GO:0010457 centriole-centriole cohesion;GO:0007099 centriole replication;GO:0032053 ciliary basal body organization;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R4Y8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCL5-1", "uniprot_id": [ { "id": "S17A9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCL5", "type": "external" } ], "mass": 48479.0, "length": 447, "protein_name": "Voltage-gated purine nucleotide uniporter SLC17A9", "gene_name": "Slc17a9", "organism": "Mouse", "refseq_name": "voltage-gated purine nucleotide uniporter SLC17A9", "refseq_ac": [ { "id": "NP_898984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898984", "type": "external" } ], "gene_names_uniprotkb": "Slc17a9", "gene_names_refseq": "1700019H03Rik; Slc17a9; Vnut", "protein_names_uniprotkb": "Voltage-gated purine nucleotide uniporter SLC17A9; Solute carrier family 17 member 9; VNUT; Vesicular nucleotide transporter", "protein_names_refseq": "vesicular nucleotide transporter; voltage-gated purine nucleotide uniporter SLC17A9", "tax_id": 10090, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (mmu:228993)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18375752;20382737;21613220;21810784;23832620;23876310;24962569;25428506;27477609;30779550;34428180", "class_list": "", "function": "Analysis of involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation, [RefSeq, PubMed]; SLC17A9 protein acts as a vesicular nucleotide transporter (VNUT) and plays an essential role in vesicular storage of ATP in the ATP-secreting cells, [RefSeq, PubMed]; The existence of an SLC17A9-dependent ATP-enriched vesicular pool in biliary epithelium that undergoes regulated exocytosis to initiate purinergic signaling., [RefSeq, PubMed]; VNUT mediates transport of ATP into synaptic vesicles of hippocampal neurons., [RefSeq, PubMed]; Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:23876310, PubMed:24962569, PubMed:27477609). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (PubMed:23832620, PubMed:24962569, PubMed:27477609). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ51", "ec_number_list": [], "go_molecular_function": "GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity;GO:0001409 guanine nucleotide transmembrane transporter activity;GO:0160042 purine nucleotide uniporter activity", "go_cellular_component": "GO:0030141 secretory granule;GO:0005765 lysosomal membrane;GO:0030658 transport vesicle membrane;GO:0042584 chromaffin granule membrane;GO:0098594 mucin granule", "go_biological_process": "GO:0015866 ADP transport;GO:1905146 lysosomal protein catabolic process;GO:1903790 guanine nucleotide transmembrane transport;GO:0015867 ATP transport;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VCL5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCZ8-1", "uniprot_id": [ { "id": "RUSD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCZ8", "type": "external" } ], "mass": 34231.0, "length": 306, "protein_name": "Pseudouridylate synthase RPUSD1", "gene_name": "Rpusd1", "organism": "Mouse", "refseq_name": "RNA pseudouridylate synthase domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_082285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082285", "type": "external" } ], "gene_names_uniprotkb": "Rpusd1; Rlucl", "gene_names_refseq": "2310051D06Rik; Rlucl; Rpusd1", "protein_names_uniprotkb": "Pseudouridylate synthase RPUSD1; 5.4.99.-; RNA pseudouridylate synthase domain-containing protein 1; Ribosomal large subunit pseudouridine synthase C-like protein", "protein_names_refseq": "RNA pseudouridylate synthase domain-containing protein 1 isoform 1; RNA pseudouridylate synthase domain-containing protein 1; ribosomal large subunit pseudouridine synthase C-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:106707)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Pseudouridylate synthase that catalyzes the conversion of uridine to pseudouridine in cytoplasmic tRNAs. Catalyzes pseudouridylation of pseudouridine-30 and pseudouridine-72 from uracil-30 and uracil-72 within the anticodon stem of cytoplasmic tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.42", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.42", "type": "external" }, { "id": "5.4.99.28", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.28", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0001522 pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VCZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDS4-1", "uniprot_id": [ { "id": "RPR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDS4", "type": "external" } ], "mass": 35701.0, "length": 312, "protein_name": "Regulation of nuclear pre-mRNA domain-containing protein 1A", "gene_name": "Rprd1a", "organism": "Mouse", "refseq_name": "regulation of nuclear pre-mRNA domain-containing protein 1A", "refseq_ac": [ { "id": "NP_659110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659110", "type": "external" } ], "gene_names_uniprotkb": "Rprd1a; Kiaa4077; P15rs", "gene_names_refseq": "Rprd1a; mKIAA4077", "protein_names_uniprotkb": "Regulation of nuclear pre-mRNA domain-containing protein 1A; Cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein", "protein_names_refseq": "cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein; regulation of nuclear pre-mRNA domain-containing protein 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:225283); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTP5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000993 RNA polymerase II complex binding;GO:0099122 RNA polymerase II C-terminal domain binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001111 RNA polymerase II promoter clearance;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VDS4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922H7-1", "uniprot_id": [ { "id": "RSLBB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922H7", "type": "external" } ], "mass": 27362.0, "length": 247, "protein_name": "Ras-like protein family member 11B", "gene_name": "Rasl11b", "organism": "Mouse", "refseq_name": "ras-like protein family member 11B", "refseq_ac": [ { "id": "NP_081154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081154", "type": "external" } ], "gene_names_uniprotkb": "Rasl11b", "gene_names_refseq": "1190017B18Rik; Rasl11b", "protein_names_uniprotkb": "Ras-like protein family member 11B; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 11B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15033445;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0S0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0005160 transforming growth factor beta receptor binding;GO:0003925 G protein activity", "go_cellular_component": "", "go_biological_process": "GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q922H7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924T2-1", "uniprot_id": [ { "id": "RT02_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924T2", "type": "external" } ], "mass": 32313.0, "length": 291, "protein_name": "Small ribosomal subunit protein uS2m", "gene_name": "Mrps2", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS2m isoform 2", "refseq_ac": [ { "id": "NP_001159503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159503", "type": "external" } ], "gene_names_uniprotkb": "Mrps2", "gene_names_refseq": "1500019M10Rik; Mrps2", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2m; 28S ribosomal protein S2, mitochondrial; MRP-S2; S2mt", "protein_names_refseq": "28S ribosomal protein S2, mitochondrial; MRP-S2; S2mt; small ribosomal subunit protein uS2m isoform 2; small ribosomal subunit protein uS2m", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); combined oxidative phosphorylation deficiency 36 (Disease Ontology:DOID:0111482)", "pathway": " (mmu:118451); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9837999); (R-MMU-9937383)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11402041;36288343;37507081", "class_list": "", "function": "Required for mitoribosome formation and stability, and mitochondrial translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AK29;Q3TMF8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924T2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JH1-1", "uniprot_id": [ { "id": "RP25L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JH1", "type": "external" } ], "mass": 17675.0, "length": 163, "protein_name": "Ribonuclease P protein subunit p25-like protein", "gene_name": "Rpp25l", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p25-like protein", "refseq_ac": [ { "id": "NP_081554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081554", "type": "external" } ], "gene_names_uniprotkb": "Rpp25l", "gene_names_refseq": "2810432D09Rik; Rpp25l; Rppl25", "protein_names_uniprotkb": "Ribonuclease P protein subunit p25-like protein; RNase P protein subunit-like p25; Rpp25-like protein", "protein_names_refseq": "RNase P protein subunit-like p25; alba-like protein C9orf23 homolog; ribonuclease P protein subunit p25-like protein; rpp25-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69961)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "36852467;40021952", "class_list": "", "function": "May be a component of ribonuclease P or MRP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYX4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99JH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K95-1", "uniprot_id": [ { "id": "RTF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K95", "type": "external" } ], "mass": 33935.0, "length": 307, "protein_name": "Replication termination factor 2", "gene_name": "Rtf2", "organism": "Mouse", "refseq_name": "replication termination factor 2", "refseq_ac": [ { "id": "NP_079818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079818", "type": "external" } ], "gene_names_uniprotkb": "Rtf2; Rtfdc1", "gene_names_refseq": "1700067C04Rik; 2410001C21Rik; 5730427M17Rik; Rtf2; Rtfdc1", "protein_names_uniprotkb": "Replication termination factor 2; RTF2; Replication termination factor 2 domain-containing protein 1", "protein_names_refseq": "UPF0549 protein C20orf43 homolog; likely orthologue of H. sapiens chromosome 20 open reading frame 43 (C20orf43); protein RTF2 homolog; replication termination factor 2 domain containing 1; replication termination factor 2 domain-containing protein 1; replication termination factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66404)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "25428506;25605945;30084848;30779550;31219806;34428180;35820727;36210013;37828378", "class_list": "glycogene;glycosyltransferase", "function": "Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APA0;Q543D3;Q80X88;Q9CV27", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005657 replication fork", "go_biological_process": "GO:0097752 regulation of DNA stability;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99K95-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LF4-1", "uniprot_id": [ { "id": "RTCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LF4", "type": "external" } ], "mass": 55249.0, "length": 505, "protein_name": "RNA-splicing ligase RTCB", "gene_name": "Rtcb", "organism": "Mouse", "refseq_name": "RNA-splicing ligase RTCB", "refseq_ac": [ { "id": "NP_663397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663397", "type": "external" } ], "gene_names_uniprotkb": "Rtcb; D10Wsu52e", "gene_names_refseq": "D10Wsu52e; FAAP; HSPC117; Rtcb", "protein_names_uniprotkb": "RNA-splicing ligase RTCB; 3'-phosphate/5'-hydroxy nucleic acid ligase; 6.5.1.8; FAAP; Focal adhesion-associated protein; RNA 2',3'-cyclic phosphate and 5'-OH ligase", "protein_names_refseq": "3'-phosphate/5'-hydroxy nucleic acid ligase; RNA-splicing ligase RTCB; RNA-splicing ligase RtcB homolog; focal adhesion-associated protein; tRNA-splicing ligase RtcB homolog", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:28088)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "18508721;20173027;20510672;21046479;21196315;25428506;25605945;25917546;29187734;30084848;30779550;31219806;34203471;34428180;34591784;34887587;36178098;37453647;37507081;38425245", "class_list": "", "function": "3'-5' RNA ligase, catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation. The ligation reaction, which requires guanosine triphosphate (GTP) and Mn(2+), proceeds through three metal-dependent steps. The first step requires ZBTB8OS/Archease and involves the guanylylation of RTCB at its active site histidine, forming a covalent GMP-histidine intermediate. Before the second step, RTCB also hydrolyzes the 2',3'-cyclic phosphate (cP) at the 3' end of the 5' tRNA exon, typically generated by the tRNA-splicing endonuclease, producing a 3' phosphate. The covalently bound GMP is then transferred to this 3' phosphate to form an RNA(3')-P-P-(5')G intermediate. In the final step, the 5'-OH of the 3' exon attacks the activated 3' end of the 5' exon, forming a 3'-5' phosphodiester bond and releasing GMP. RTCB also functions in non-canonical, spliceosome-independent, cytoplasmic splicing of XBP1 mRNAs during the unfolded protein response (UPR). Upon endoplasmic reticulum (ER) stress, the endoribonuclease IRE1/ERN1 excises a short intron, generating free exon ends that are aligned by RNA-intrinsic, zipper-like stem-loop structures. These exon ends are then recognized and ligated by RTCB. This splicing event yields the active XBP1s transcription factor, which induces genes required to resolve protein folding defects in the endoplasmic reticulum., [UniProtKB, UniProtKB]; D10Wsu52e may be related to the acinar development, adhesion and migration of progenitors and endocrine precursors. Publication Status: Online-Only, [RefSeq, PubMed]; Defects in HSPC117 expression may be an important contributing factor to loss of cloned nuclear transfer embryos in vivo., [RefSeq, PubMed]; FAAP (D10Wsu52e) mRNA and protein expression are highly regionalized in the mouse epididymis with predominant enrichment in the initial segment; during sexual maturation, FAAP mRNA is always expressed in the caput epididymides, [RefSeq, PubMed]; RTCB deficiency triggers colitis in mice by influencing the NF-kappaB and Wnt/beta-catenin signaling pathways., [RefSeq, PubMed]; The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance., [RefSeq, PubMed]; This novel Faap20 mouse model may be valuable in studying the regulation of the FA pathway during bone marrow failure progress in FA patients., [RefSeq, PubMed]; YY1 and RTCB in mouse uterine decidualization and embryo implantation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA04;Q3TI25;Q3UDW6", "ec_number_list": [ { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "6.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.8", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0017166 vinculin binding;GO:0044600 protein guanylyltransferase activity;GO:0170057 RNA ligase (GTP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:0001701 in utero embryonic development;GO:0036498 IRE1-mediated unfolded protein response;GO:0001890 placenta development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99LF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M03-1", "uniprot_id": [ { "id": "RWD2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M03", "type": "external" } ], "mass": 32892.0, "length": 290, "protein_name": "RWD domain-containing protein 2B", "gene_name": "Rwdd2b", "organism": "Mouse", "refseq_name": "RWD domain-containing protein 2B", "refseq_ac": [ { "id": "NP_058620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058620", "type": "external" } ], "gene_names_uniprotkb": "Rwdd2b; ORF5", "gene_names_refseq": "ORF5; Rwdd2b", "protein_names_uniprotkb": "RWD domain-containing protein 2B", "protein_names_refseq": "RWD domain-containing protein 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:53858); (R-MMU-3065678)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10729227;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLH4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99M03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M28-1", "uniprot_id": [ { "id": "RNPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M28", "type": "external" } ], "mass": 34208.0, "length": 305, "protein_name": "RNA-binding protein with serine-rich domain 1", "gene_name": "Rnps1", "organism": "Mouse", "refseq_name": "RNA-binding protein with serine-rich domain 1 isoform 1", "refseq_ac": [ { "id": "NP_001073596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073596", "type": "external" } ], "gene_names_uniprotkb": "Rnps1", "gene_names_refseq": "Rnps1", "protein_names_uniprotkb": "RNA-binding protein with serine-rich domain 1", "protein_names_refseq": "RNA-binding protein with serine-rich domain 1 isoform 1; ribonucleic acid binding protein S1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19826); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-975957)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;23806337;31831174;35482923", "class_list": "", "function": "Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity)., [UniProtKB]; RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death., [RefSeq, PubMed]; RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMJ1;Q922H8", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0061574 ASAP complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0050684 regulation of mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99M28-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N84-1", "uniprot_id": [ { "id": "RT18B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N84", "type": "external" } ], "mass": 28703.0, "length": 254, "protein_name": "Small ribosomal subunit protein mS40", "gene_name": "Mrps18b", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS40 isoform 1", "refseq_ac": [ { "id": "NP_080154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080154", "type": "external" } ], "gene_names_uniprotkb": "Mrps18b", "gene_names_refseq": "2400002C15Rik; MRP-S18-2; Mrps18b; S18mt-b", "protein_names_uniprotkb": "Small ribosomal subunit protein mS40; 28S ribosomal protein S18-2, mitochondrial; 28S ribosomal protein S18b, mitochondrial; MRP-S18-2; MRP-S18-b; Mrps18-b; S18mt-b", "protein_names_refseq": "28S ribosomal protein S18-2, mitochondrial; 28S ribosomal protein S18b, mitochondrial; small ribosomal subunit protein mS40 isoform 1; small ribosomal subunit protein mS40", "tax_id": 10090, "disease": "", "pathway": " (mmu:66973); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11402041;21750661;31219806;32571933;34428180", "class_list": "", "function": "Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLA9;Q9CRK0;Q9DCR8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030054 cell junction", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99N84-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N89-1", "uniprot_id": [ { "id": "RM43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N89", "type": "external" } ], "mass": 20203.0, "length": 183, "protein_name": "Large ribosomal subunit protein mL43", "gene_name": "Mrpl43", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrpl43", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein mL43; 39S ribosomal protein L43, mitochondrial; L43mt; MRP-L43; Mitochondrial ribosomal protein bMRP36a", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11279069;15509589", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99N89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N91-1", "uniprot_id": [ { "id": "RM34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N91", "type": "external" } ], "mass": 10531.0, "length": 92, "protein_name": "Large ribosomal subunit protein bL34m", "gene_name": "Mrpl34", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL34m", "refseq_ac": [ { "id": "NP_444392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444392", "type": "external" } ], "gene_names_uniprotkb": "Mrpl34", "gene_names_refseq": "0610007O17Rik; D8Bwg1484e; Mrpl34", "protein_names_uniprotkb": "Large ribosomal subunit protein bL34m; 39S ribosomal protein L34, mitochondrial; L34mt; MRP-L34", "protein_names_refseq": "39S ribosomal protein L34, mitochondrial; L34mt; MRP-L34; large ribosomal subunit protein bL34m", "tax_id": 10090, "disease": "", "pathway": " (mmu:94065); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11279069;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDJ8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N94-1", "uniprot_id": [ { "id": "RM09_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N94", "type": "external" } ], "mass": 30244.0, "length": 265, "protein_name": "Large ribosomal subunit protein bL9m", "gene_name": "Mrpl9", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL9m isoform 1", "refseq_ac": [ { "id": "NP_084392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084392", "type": "external" } ], "gene_names_uniprotkb": "Mrpl9", "gene_names_refseq": "8030480E20Rik; C330013D18Rik; L9mt; Mrpl9", "protein_names_uniprotkb": "Large ribosomal subunit protein bL9m; 39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9", "protein_names_refseq": "39S ribosomal protein L9, mitochondrial; MRP-L9; large ribosomal subunit protein bL9m isoform 1; large ribosomal subunit protein bL9m", "tax_id": 10090, "disease": "", "pathway": " (mmu:78523); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11279069;25428506;30084848;34428180;37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSJ0;Q8BQZ2", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99N94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQE0-1", "uniprot_id": [ { "id": "RN138_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQE0", "type": "external" } ], "mass": 28299.0, "length": 245, "protein_name": "E3 ubiquitin-protein ligase RNF138", "gene_name": "Rnf138", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF138 isoform 3", "refseq_ac": [ { "id": "NP_001289934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289934", "type": "external" } ], "gene_names_uniprotkb": "Rnf138; Trif", "gene_names_refseq": "2410015A17Rik; 2810480D20Rik; Rnf138; STRIN; Trif-d; Trif", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF138; 2.3.2.27; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF138 isoform 3; E3 ubiquitin-protein ligase RNF138; RING-type E3 ubiquitin transferase RNF138", "tax_id": 10090, "disease": "", "pathway": " (mmu:56515); (R-MMU-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;29187734;35697692;38156932", "class_list": "", "function": "E3 ubiquitin-ligase RNF138 may regulate p53 protein expression to regulate the self-renewal and tumorigenicity of glioma stem cells., [RefSeq, PubMed]; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway., [UniProtKB, UniProtKB]; RING finger 138 deregulation distorts NF-small ka, CyrillicB signaling and facilities colitis switch to aggressive malignancy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTR9;Q9WTS0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0061630 ubiquitin protein ligase activity;GO:0003697 single-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse;GO:0035861 site of double-strand break;GO:0098793 presynapse;GO:0005694 chromosome", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQF8-1", "uniprot_id": [ { "id": "RT63_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQF8", "type": "external" } ], "mass": 11952.0, "length": 102, "protein_name": "Large ribosomal subunit protein mL63", "gene_name": "Mrpl57", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL63", "refseq_ac": [ { "id": "NP_080677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080677", "type": "external" } ], "gene_names_uniprotkb": "Mrpl57; Mrp63", "gene_names_refseq": "2610025P17Rik; Mrp63; Mrpl57", "protein_names_uniprotkb": "Large ribosomal subunit protein mL63; Mitochondrial ribosomal protein 63; Mitochondrial ribosomal protein L57; Ribosomal protein 63, mitochondrial; mMRP63", "protein_names_refseq": "large ribosomal subunit protein mL63; mMRP63; mitochondrial ribosomal protein 63; mitochondrial ribosomal protein L53; ribosomal protein 63, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:67840); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11402041", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQR2-1", "uniprot_id": [ { "id": "RS21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQR2", "type": "external" } ], "mass": 9141.0, "length": 83, "protein_name": "Small ribosomal subunit protein eS21", "gene_name": "Rps21", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS21", "refseq_ac": [ { "id": "NP_079863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079863", "type": "external" } ], "gene_names_uniprotkb": "Rps21", "gene_names_refseq": "1810049N11Rik; 2410030A14Rik; Rps21", "protein_names_uniprotkb": "Small ribosomal subunit protein eS21; 40S ribosomal protein S21", "protein_names_refseq": "40S ribosomal protein S21; small ribosomal subunit protein eS21", "tax_id": 10090, "disease": "", "pathway": " (mmu:66481); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 7, "publication_id_list": "25605945;33949947;34428180;35820727;36288343;36517592;37828378", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9L3", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181 cytoplasmic translation;GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQV5-1", "uniprot_id": [ { "id": "RT24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQV5", "type": "external" } ], "mass": 18901.0, "length": 167, "protein_name": "Small ribosomal subunit protein uS3m", "gene_name": "Mrps24", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS3m isoform 1 precursor", "refseq_ac": [ { "id": "NP_080356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080356", "type": "external" } ], "gene_names_uniprotkb": "Mrps24", "gene_names_refseq": "3110030K20Rik; MRP-S24; Mrps24; Rpms24; S24mt", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3m; 28S ribosomal protein S24, mitochondrial; MRP-S24; S24mt", "protein_names_refseq": "28S ribosomal protein S24, mitochondrial; ribosomal protein, mitochondrial, S24; small ribosomal subunit protein uS3m isoform 1 precursor; small ribosomal subunit protein uS3m", "tax_id": 10090, "disease": "", "pathway": " (mmu:64660); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQV5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CSH3-1", "uniprot_id": [ { "id": "RRP44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CSH3", "type": "external" } ], "mass": 108838.0, "length": 958, "protein_name": "Exosome complex exonuclease RRP44", "gene_name": "Dis3", "organism": "Mouse", "refseq_name": "exosome complex exonuclease RRP44 isoform 1", "refseq_ac": [ { "id": "NP_082591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082591", "type": "external" } ], "gene_names_uniprotkb": "Dis3; Kiaa1008; Rrp44", "gene_names_refseq": "2810028N01Rik; Dis3", "protein_names_uniprotkb": "Exosome complex exonuclease RRP44; 3.1.13.-; 3.1.26.-; Protein DIS3 homolog; Ribosomal RNA-processing protein 44", "protein_names_refseq": "DIS3 mitotic control homolog; exosome complex exonuclease RRP44 isoform 1; exosome complex exonuclease RRP44; protein DIS3 homolog; ribosomal RNA-processing protein 44", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:72662); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "21183079;21750661;22645316;34428180;38953252;39627609", "class_list": "", "function": "DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice. Erratum:[Development. 2024 Sep 1;151(17):dev204238. doi: 10.1242/dev.204238. PMID: 39225297], [RefSeq, PubMed]; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ07;Q8C074", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0004519 endonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0006396 RNA processing;GO:0006364 rRNA processing;GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process;GO:0071034 CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CSH3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXW2-1", "uniprot_id": [ { "id": "RT22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXW2", "type": "external" } ], "mass": 41192.0, "length": 359, "protein_name": "Small ribosomal subunit protein mS22", "gene_name": "Mrps22", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS22", "refseq_ac": [ { "id": "NP_079761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079761", "type": "external" } ], "gene_names_uniprotkb": "Mrps22; Rpms22", "gene_names_refseq": "3100002P07Rik; Mrps22; Rpms22", "protein_names_uniprotkb": "Small ribosomal subunit protein mS22; 28S ribosomal protein S22, mitochondrial; MRP-S22; S22mt", "protein_names_refseq": "28S ribosomal protein S22, mitochondrial; MRP-S22; S22mt; ribosomal protein, mitochondrial, S22; small ribosomal subunit protein mS22", "tax_id": 10090, "disease": "ovarian dysgenesis 7 (Disease Ontology:DOID:0080499); combined oxidative phosphorylation deficiency 5 (Disease Ontology:DOID:0111473); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:64655); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "26495903;29566152;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3T2;Q8VDG9;Q9D185", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CXW2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYX7-1", "uniprot_id": [ { "id": "RRP15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYX7", "type": "external" } ], "mass": 31058.0, "length": 281, "protein_name": "RRP15-like protein", "gene_name": "Rrp15", "organism": "Mouse", "refseq_name": "RRP15-like protein", "refseq_ac": [ { "id": "NP_080317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080317", "type": "external" } ], "gene_names_uniprotkb": "Rrp15", "gene_names_refseq": "2810430M08Rik; 5430437H21Rik; Rrp15", "protein_names_uniprotkb": "RRP15-like protein; Ribosomal RNA-processing protein 15", "protein_names_refseq": "RRP15-like protein; ribosomal RNA-processing protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:67223)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15769876;17242355;21183079;24463520;34428180;36834940", "class_list": "", "function": "Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The budding yeast homolog of Rrp15 is required for maturation of 60S ribosomal particles., [RefSeq, PubMed]; This gene encodes a protein similar to budding yeast Rrp15p. Rrp15p is a component of pre-60S ribosomal particles in budding yeast, and is required for the early maturation steps of the 60S subunit. The mouse genome contains at least one pseudogene on the X chromosome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BU28;Q922T8;Q9CWJ2;Q9D8W8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CYX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZT4-1", "uniprot_id": [ { "id": "RPC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZT4", "type": "external" } ], "mass": 79854.0, "length": 710, "protein_name": "DNA-directed RNA polymerase III subunit RPC5", "gene_name": "Polr3e", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC5 isoform 2", "refseq_ac": [ { "id": "NP_001157568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157568", "type": "external" } ], "gene_names_uniprotkb": "Polr3e; Sin", "gene_names_refseq": "Polr3e; RPC5; Sin", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III subunit 5; RNA polymerase III subunit C5; Sex-lethal interactor homolog; Sxl interactor", "protein_names_refseq": "DNA-directed RNA polymerase III subunit RPC5 isoform 2; DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III polypeptide E; RNA polymerase III subunit 5; RNA polymerase III subunit C5; sex-lethal interactor homolog; sxl interactor", "tax_id": 10090, "disease": "chromosome 16p12.1 deletion syndrome (Disease Ontology:DOID:0060399)", "pathway": " (mmu:26939); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17242355;20404100;21183079;25428506;28289142;30084848;34428180", "class_list": "", "function": "A mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, affects Polr3e expression through transcriptional interference, [RefSeq, PubMed]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results identify Sin as a novel regulator of medullary thymic epithelial cell development and t cell tolerance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI35;Q9DBD1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CZT4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1I6-1", "uniprot_id": [ { "id": "RM14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1I6", "type": "external" } ], "mass": 15874.0, "length": 145, "protein_name": "Large ribosomal subunit protein uL14m", "gene_name": "Mrpl14", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL14m precursor", "refseq_ac": [ { "id": "NP_081008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081008", "type": "external" } ], "gene_names_uniprotkb": "Mrpl14", "gene_names_refseq": "1110006I11Rik; MRP-L32; Mrpl14; Rpml32", "protein_names_uniprotkb": "Large ribosomal subunit protein uL14m; 39S ribosomal protein L14, mitochondrial; L14mt; MRP-L14", "protein_names_refseq": "39S ribosomal protein L14, mitochondrial; L14mt; MRP-L14; large ribosomal subunit protein uL14m precursor; large ribosomal subunit protein uL14m; mitochondrial ribosomal protein L32", "tax_id": 10090, "disease": "", "pathway": " (mmu:68463); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "25428506;34428180", "class_list": "", "function": "May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNL3", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D1I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2R8-1", "uniprot_id": [ { "id": "RT33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2R8", "type": "external" } ], "mass": 12459.0, "length": 106, "protein_name": "Small ribosomal subunit protein mS33", "gene_name": "Mrps33", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS33 isoform 1", "refseq_ac": [ { "id": "NP_034400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034400", "type": "external" } ], "gene_names_uniprotkb": "Mrps33; Gdap3", "gene_names_refseq": "CGI-139; Gdap3; MRP-S33; Mrps33; PTD003", "protein_names_uniprotkb": "Small ribosomal subunit protein mS33; 28S ribosomal protein S33, mitochondrial; Ganglioside-induced differentiation-associated-protein 3; MRP-S33; S33mt", "protein_names_refseq": "28S ribosomal protein S33, mitochondrial; S33mt; ganglioside-induced differentiation-associated-protein 3; small ribosomal subunit protein mS33 isoform 1; small ribosomal subunit protein mS33", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:14548); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10217254;34428180;36288343;37979395", "class_list": "", "function": "SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88743", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D2R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9R0-1", "uniprot_id": [ { "id": "RN125_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9R0", "type": "external" } ], "mass": 26362.0, "length": 233, "protein_name": "E3 ubiquitin-protein ligase RNF125", "gene_name": "Rnf125", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF125 isoform 1", "refseq_ac": [ { "id": "NP_080577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080577", "type": "external" } ], "gene_names_uniprotkb": "Rnf125", "gene_names_refseq": "4930553F04Rik; C730049O14Rik; Rnf125", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF125; 2.3.2.27; RING finger protein 125", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF125 isoform 1; E3 ubiquitin-protein ligase RNF125", "tax_id": 10090, "disease": "", "pathway": " (mmu:67664)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17460044;26202983;28476934;31999304;34428180;36344734;37978243", "class_list": "", "function": "CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation., [RefSeq, PubMed]; Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a reciprocal correlation between microRNA miR-15b levels and the expression of ring finger protein 125 (RNF125)., [RefSeq, PubMed]; E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation., [UniProtKB, UniProtKB]; RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production, [RefSeq, PubMed]; Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia., [RefSeq, PubMed]; Study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG32;Q52KL4;Q8C7F2", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0002250 adaptive immune response;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0039536 negative regulation of RIG-I signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D9R0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA80-1", "uniprot_id": [ { "id": "RSH3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA80", "type": "external" } ], "mass": 45168.0, "length": 389, "protein_name": "Radial spoke head protein 3 homolog B", "gene_name": "Rsph3b", "organism": "Mouse", "refseq_name": "radial spoke head protein 3 homolog B", "refseq_ac": [ { "id": "NP_001077414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077414", "type": "external" } ], "gene_names_uniprotkb": "Rsph3b; Rshl2b; Rshl2", "gene_names_refseq": "Rshl2b; Rsph3b", "protein_names_uniprotkb": "Radial spoke head protein 3 homolog B; A-kinase anchor protein RSPH3B; Radial spoke head-like protein 2B", "protein_names_refseq": "A-kinase anchor protein RSPH3B; radial spoke head protein 3 homolog B; radial spoke head-like protein 2B; radial spokehead-like 2B", "tax_id": 10090, "disease": "primary ciliary dyskinesia 32 (Disease Ontology:DOID:0110603)", "pathway": " (mmu:100037282)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25079589;26082196;34428180;34871179", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:34871179). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results suggest that RSP3 is a nucleocytoplasmic shuttling protein and plays an essential role in neurogenesis., [RefSeq, PubMed]; The subcellular localization and function of mammalian RSP3 in mammalian cells and developing CNS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DA80-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES88-1", "uniprot_id": [ { "id": "S13A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES88", "type": "external" } ], "mass": 64111.0, "length": 586, "protein_name": "Solute carrier family 13 member 2", "gene_name": "Slc13a2", "organism": "Mouse", "refseq_name": "solute carrier family 13 member 2", "refseq_ac": [ { "id": "NP_071856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071856", "type": "external" } ], "gene_names_uniprotkb": "Slc13a2; Nadc1; Sdct1", "gene_names_refseq": "Nadc-1; Nadc1; Slc13a2; mNaDC-1", "protein_names_uniprotkb": "Solute carrier family 13 member 2; Na(+)/dicarboxylate cotransporter 1; NaDC-1; Renal sodium/dicarboxylate cotransporter", "protein_names_refseq": "Na(+)/dicarboxylate cotransporter 1; renal sodium/dicarboxylate cotransporter; sodium/dicarboxylate co-transporter; solute carrier family 13 member 2", "tax_id": 10090, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20500); (R-MMU-9955298)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10966927;16475819;17410095;23833257;31188034;34428180", "class_list": "", "function": "Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (By similarity) (PubMed:10966927). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10966927). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (By similarity). Has a critical role in renal dicarboxylate transport (PubMed:17410095)., [UniProtKB, UniProtKB, PubMed, PubMed]; NaDC1 expression increased only in the proximal convoluted tubules and proximal straight tubules in knockout mice blocked both the citrate and NaDC1 changes, [RefSeq, PubMed]; Slc26a6-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1., [RefSeq, PubMed]; Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0015141 succinate transmembrane transporter activity;GO:0015138 fumarate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071285 cellular response to lithium ion;GO:0015742 alpha-ketoglutarate transport;GO:0071422 succinate transmembrane transport;GO:0015741 fumarate transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ES88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ80-1", "uniprot_id": [ { "id": "RPF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ80", "type": "external" } ], "mass": 35364.0, "length": 306, "protein_name": "Ribosome production factor 2 homolog", "gene_name": "Rpf2", "organism": "Mouse", "refseq_name": "ribosome production factor 2 homolog isoform 2", "refseq_ac": [ { "id": "NP_001036021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036021", "type": "external" } ], "gene_names_uniprotkb": "Rpf2; Bxdc1; MNCb-4285", "gene_names_refseq": "2810470K21Rik; Bxdc1; Rpf2", "protein_names_uniprotkb": "Ribosome production factor 2 homolog; Brix domain-containing protein 1; Ribosome biogenesis protein RPF2 homolog", "protein_names_refseq": "brix domain containing 1; brix domain-containing protein 1; ribosome biogenesis protein RPF2 homolog; ribosome production factor 2 homolog isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67239)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22645316;30084848;31219806", "class_list": "", "function": "Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3K6;Q9CQ34;Q9CSY9;Q9CYR9", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0019843 rRNA binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJ80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQA7-1", "uniprot_id": [ { "id": "SELH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQA7", "type": "external" } ], "mass": 12974.0, "length": 116, "protein_name": "Selenoprotein H", "gene_name": "Selenoh", "organism": "Mouse", "refseq_name": "selenoprotein H", "refseq_ac": [ { "id": "NP_001028338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028338", "type": "external" } ], "gene_names_uniprotkb": "Selenoh; 2700094K13Rik", "gene_names_refseq": "2700094K13Rik; Selenoh; Selh", "protein_names_uniprotkb": "Selenoprotein H; SelH", "protein_names_refseq": "selenoprotein H", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (mmu:72657)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29535592;31219806", "class_list": "", "function": "May be involved in a redox-related process., [UniProtKB, UniProtKB, UniProtKB]; Overexpression of selenoprotein H can protect cells from glutamate toxicity by preserving mitochondrial morphology and suppressing autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNQ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UQA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R139-1", "uniprot_id": [ { "id": "S29A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R139", "type": "external" } ], "mass": 58099.0, "length": 528, "protein_name": "Equilibrative nucleoside transporter 4", "gene_name": "Slc29a4", "organism": "Mouse", "refseq_name": "equilibrative nucleoside transporter 4 isoform 1", "refseq_ac": [ { "id": "NP_666369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666369", "type": "external" } ], "gene_names_uniprotkb": "Slc29a4; Ent4; pmat", "gene_names_refseq": "ENT4; PMAT; Slc29a4; mENT4; mPMAT", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 4; PMAT; Plasma membrane monoamine transporter; Solute carrier family 29 member 4; mENT4", "protein_names_refseq": "equilibrative nucleoside transporter 4 isoform 1; equilibrative nucleoside transporter 4; plasma membrane monoamine transporter; solute carrier family 29 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:243328); (R-MMU-83936)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16873718;21750661;23255610;32170814;35741002;38003684", "class_list": "", "function": "Deletion of murine slc29a4 modifies vascular responses to adenosine and 5-hydroxytryptamine in a sexually dimorphic manner., [RefSeq, PubMed]; ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia., [RefSeq, PubMed]; Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:16873718, PubMed:23255610). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (By similarity). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (By similarity). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:23255610). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (PubMed:23255610). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:23255610). Also transports adenine and guanidine (PubMed:16873718)., [UniProtKB, PubMed, PubMed, UniProtKB]; Heterotypic Stressors Unmask Behavioral Influences of PMAT Deficiency in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0008324 monoatomic cation transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015562 efflux transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0015844 monoamine transport;GO:0015695 organic cation transport;GO:0055085 transmembrane transport;GO:0098655 monoatomic cation transmembrane transport;GO:0015872 dopamine transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R139-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3D6-1", "uniprot_id": [ { "id": "S35E4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3D6", "type": "external" } ], "mass": 37253.0, "length": 351, "protein_name": "Solute carrier family 35 member E4", "gene_name": "Slc35e4", "organism": "Mouse", "refseq_name": "solute carrier family 35 member E4", "refseq_ac": [ { "id": "NP_694782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694782", "type": "external" } ], "gene_names_uniprotkb": "Slc35e4", "gene_names_refseq": "A330108F03Rik; Slc35e4", "protein_names_uniprotkb": "Solute carrier family 35 member E4", "protein_names_refseq": "solute carrier family 35 member E4", "tax_id": 10090, "disease": "", "pathway": " (mmu:103710)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative transporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F205", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K3D6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14B98-1", "uniprot_id": [ { "id": "SESQ2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14B98", "type": "external" } ], "mass": 28707.0, "length": 259, "protein_name": "Sesquipedalian-2", "gene_name": "Pheta2", "organism": "Mouse", "refseq_name": "sesquipedalian-2", "refseq_ac": [ { "id": "NP_796365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796365", "type": "external" } ], "gene_names_uniprotkb": "Pheta2; Fam109b", "gene_names_refseq": "C920005C14Rik; Fam109b; IPIP27B; Pheta2; Ses2", "protein_names_uniprotkb": "Sesquipedalian-2; 27 kDa inositol polyphosphate phosphatase interacting protein B; IPIP27B; PH domain-containing endocytic trafficking adaptor 2; Ses2", "protein_names_refseq": "27 kDa inositol polyphosphate phosphatase interacting protein B; family with sequence similarity 109, member B; sesquipedalian-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:338368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUL8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14B98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQB6-1", "uniprot_id": [ { "id": "SAXO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQB6", "type": "external" } ], "mass": 45533.0, "length": 394, "protein_name": "Stabilizer of axonemal microtubules 2", "gene_name": "Saxo2", "organism": "Mouse", "refseq_name": "stabilizer of axonemal microtubules 2 isoform 2", "refseq_ac": [ { "id": "NP_808562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808562", "type": "external" } ], "gene_names_uniprotkb": "Saxo2; Fam154b", "gene_names_refseq": "1700129I04Rik; D030069K18; Fam154b; Saxo2", "protein_names_uniprotkb": "Stabilizer of axonemal microtubules 2", "protein_names_refseq": "family with sequence similarity 154, member B; protein FAM154B; stabilizer of axonemal microtubules 2 isoform 2; stablizer of axonemal microtubules 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:330577)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9C9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0036126 sperm flagellum;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BQB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08535-1", "uniprot_id": [ { "id": "SECR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08535", "type": "external" } ], "mass": 14914.0, "length": 133, "protein_name": "Secretin", "gene_name": "Sct", "organism": "Mouse", "refseq_name": "secretin isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_035458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035458", "type": "external" } ], "gene_names_uniprotkb": "Sct", "gene_names_refseq": "Sct", "protein_names_uniprotkb": "Secretin", "protein_names_refseq": "secretin isoform 2 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20287); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "18534766;20578263;20739612;20927047;21159798;21750661;24273196;30449620;33928675;38156312;8179583", "class_list": "", "function": "Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:20578263, PubMed:20739612, PubMed:20927047, PubMed:30449620). Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells (PubMed:30449620). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (PubMed:20578263). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (PubMed:20578263). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (PubMed:20578263). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (PubMed:30449620). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (PubMed:30449620). Also able to stimulate lipolysis in white adipocytes (PubMed:24273196). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (PubMed:20739612). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (PubMed:18534766, PubMed:21159798)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes., [RefSeq, PubMed]; This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0046659 digestive hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:1903640 negative regulation of gastrin-induced gastric acid secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008542 visual learning;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08535-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04918-1", "uniprot_id": [ { "id": "SAA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P04918", "type": "external" } ], "mass": 13774.0, "length": 122, "protein_name": "Serum amyloid A-3 protein", "gene_name": "Saa3", "organism": "Mouse", "refseq_name": "serum amyloid A-3 protein precursor", "refseq_ac": [ { "id": "NP_035445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035445", "type": "external" } ], "gene_names_uniprotkb": "Saa3", "gene_names_refseq": "Saa-3; Saa3; l7R3", "protein_names_uniprotkb": "Serum amyloid A-3 protein", "protein_names_refseq": "serum amyloid A-3 protein precursor; serum amyloid A-3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20210)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;28011936;3003697;3013853;3624868;38613835;6953913", "class_list": "", "function": "Major acute phase reactant. Apolipoprotein of the HDL complex. In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (By similarity)., [UniProtKB, UniProtKB]; Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic Metabolism of Cholesterol., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62201", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0001664 G protein-coupled receptor binding;GO:0035662 Toll-like receptor 4 binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006953 acute-phase response;GO:0009617 response to bacterium;GO:0060326 cell chemotaxis;GO:0035634 response to stilbenoid;GO:0071347 cellular response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04918-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWH0-1", "uniprot_id": [ { "id": "S38A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWH0", "type": "external" } ], "mass": 49913.0, "length": 463, "protein_name": "Sodium-coupled neutral amino acid transporter 7", "gene_name": "Slc38a7", "organism": "Mouse", "refseq_name": "sodium-coupled neutral amino acid transporter 7 isoform 1", "refseq_ac": [ { "id": "NP_766346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766346", "type": "external" } ], "gene_names_uniprotkb": "Slc38a7; Snat7", "gene_names_refseq": "D430050E18; Slc38a7", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 7; Solute carrier family 38 member 7", "protein_names_refseq": "amino acid transporter; putative sodium-coupled neutral amino acid transporter 7; sodium-coupled neutral amino acid transporter 7 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234595)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21511949;21750661;28416685", "class_list": "", "function": "Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:21511949, PubMed:28416685). The transport activity requires an acidic lysosomal lumen (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The preferred substrate and axonal localization of SLC38A7 close to the synaptic cleft indicates that SLC38A7 could have an important function for the reuptake and recycling of glutamate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBN9;Q8K2B1", "ec_number_list": [], "go_molecular_function": "GO:0015186 L-glutamine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity;GO:0140901 L-asparagine:sodium symporter activity;GO:0140902 L-glutamine:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006868 glutamine transport;GO:0006814 sodium ion transport;GO:0003333 amino acid transmembrane transport;GO:0006867 asparagine transport;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BWH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCM1-1", "uniprot_id": [ { "id": "S17A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCM1", "type": "external" } ], "mass": 53668.0, "length": 492, "protein_name": "Probable small intestine urate exporter", "gene_name": "Slc17a4", "organism": "Mouse", "refseq_name": "probable small intestine urate exporter", "refseq_ac": [ { "id": "NP_795990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795990", "type": "external" } ], "gene_names_uniprotkb": "Slc17a4", "gene_names_refseq": "9130214H05Rik; Slc17a4", "protein_names_uniprotkb": "Probable small intestine urate exporter; Solute carrier family 17 member 4", "protein_names_refseq": "probable small intestine urate exporter; putative small intestine sodium-dependent phosphate transport protein; solute carrier family 17 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:319848)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22460716;34428180", "class_list": "", "function": "Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:22460716). Mediates chloride-dependent transport of urate (PubMed:22460716). Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) (By similarity). Can actively transport inorganic phosphate into cells via Na(+) cotransport (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B9EJP0", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5NCM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TMH2-1", "uniprot_id": [ { "id": "SCRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TMH2", "type": "external" } ], "mass": 47661.0, "length": 418, "protein_name": "Secernin-3", "gene_name": "Scrn3", "organism": "Mouse", "refseq_name": "secernin-3 isoform 1", "refseq_ac": [ { "id": "NP_083298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083298", "type": "external" } ], "gene_names_uniprotkb": "Scrn3", "gene_names_refseq": "4833415E20Rik; Scrn3; Ses3", "protein_names_uniprotkb": "Secernin-3", "protein_names_refseq": "secernin-3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74616)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;30084848;34418053;34428180;36924917;39927985", "class_list": "", "function": "Plays a role in thermal nociception., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AWR0;Q91WF6;Q9CUT0", "ec_number_list": [], "go_molecular_function": "GO:0016805 dipeptidase activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3TMH2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8Y5H7-1", "uniprot_id": [ { "id": "S14L1_MOUSE", "url": "https://www.uniprot.org/uniprot/A8Y5H7", "type": "external" } ], "mass": 81216.0, "length": 715, "protein_name": "SEC14-like protein 1", "gene_name": "Sec14l1", "organism": "Mouse", "refseq_name": "SEC14-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001159978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159978", "type": "external" } ], "gene_names_uniprotkb": "Sec14l1; Kiaa4251", "gene_names_refseq": "1200017E04Rik; 2810012L19Rik; Naa-35; Sec14l1", "protein_names_uniprotkb": "SEC14-like protein 1", "protein_names_refseq": "SEC14-like protein 1 isoform 2; SEC14-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74136)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15531584;31219806;34428180;36210013;40021952", "class_list": "", "function": "May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters., [UniProtKB, UniProtKB]; The Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A9B9;Q6A071;Q99J07;Q9DBQ0", "ec_number_list": [], "go_molecular_function": "GO:0039552 RIG-I binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0015871 choline transport;GO:0039536 negative regulation of RIG-I signaling pathway;GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway;GO:0002753 cytoplasmic pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A8Y5H7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64519-1", "uniprot_id": [ { "id": "SDC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64519", "type": "external" } ], "mass": 46002.0, "length": 442, "protein_name": "Syndecan-3", "gene_name": "Sdc3", "organism": "Mouse", "refseq_name": "syndecan-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035650", "type": "external" } ], "gene_names_uniprotkb": "Sdc3; Kiaa0468", "gene_names_refseq": "Sdc3; Synd3; mKIAA0468; syn-3", "protein_names_uniprotkb": "Syndecan-3; SYND3", "protein_names_refseq": "syndecan-3 isoform 1 precursor", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20970); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-3000170); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "12084985;21750661;25428506;26740625;33300544;34203471;34428180;35328830;36898477", "class_list": "glycogene", "function": "Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity)., [UniProtKB]; Syndecan-3 as a Novel Biomarker in Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Syndecan-3 regulates the time of transition from cell cycle exit to initial differentiation stage in mouse cerebellar granule cell precursors., [RefSeq, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 0, "predicted_o_glycosites": 14, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDD9;Q6ZQA4;Q7TQD4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0044393 microspike;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64519-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z2R5-1", "uniprot_id": [ { "id": "SELN_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z2R5", "type": "external" } ], "mass": 62492.0, "length": 557, "protein_name": "Selenoprotein N", "gene_name": "Selenon", "organism": "Mouse", "refseq_name": "selenoprotein N precursor", "refseq_ac": [ { "id": "NP_083376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083376", "type": "external" } ], "gene_names_uniprotkb": "Selenon; Seln; Sepn1", "gene_names_refseq": "1110019I12Rik; SelN; Selenon; Sepn1", "protein_names_uniprotkb": "Selenoprotein N; SelN", "protein_names_refseq": "selenoprotein N precursor; selenoprotein N, 1", "tax_id": 10090, "disease": "congenital myopathy (Disease Ontology:DOID:0081337); rigid spine muscular dystrophy 1 (Disease Ontology:DOID:0110633)", "pathway": " (mmu:74777)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19698141;21131290;21858002;25452428;30391828;32661288;34428180", "class_list": "", "function": "Data show that Sepn1(-/-) mice developed an obvious phenotype, characterized by limited motility and body rigidity during the swimming session., [RefSeq, PubMed]; Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy., [RefSeq, PubMed]; In whole embryos, Sepn1 transcripts were detected as early as E5.5, with expression levels peaking at E12.5, and then strongly decreasing until birth. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (By similarity). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290)., [UniProtKB, PubMed, PubMed, UniProtKB]; These findings suggest that SELENON is part of an ER stress-dependent antioxidant response and that the CHOP/ERO1 branch of the ER stress response is a novel pathogenic mechanism underlying SELENON-related myopathies., [RefSeq, PubMed]; This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in the orthologous gene in human are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. Knockout mice deleted for this gene exhibit abnormal lung development. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. [provided by RefSeq, Dec 2016]., [RefSeq]; We describe for the first time a major physiological function of SelN in skeletal muscles, as a key regulator of SC function, which likely plays a central role in the pathophysiological mechanism leading to SEPN1-RM., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0015882 L-ascorbic acid transmembrane transport;GO:0014816 skeletal muscle satellite cell differentiation;GO:0014858 positive regulation of skeletal muscle cell proliferation;GO:0022614 membrane to membrane docking", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "D3Z2R5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VG18-1", "uniprot_id": [ { "id": "SIM24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VG18", "type": "external" } ], "mass": 13547.0, "length": 120, "protein_name": "Small integral membrane protein 24", "gene_name": "Smim24", "organism": "Mouse", "refseq_name": "small integral membrane protein 24 precursor", "refseq_ac": [ { "id": "NP_001093387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093387", "type": "external" } ], "gene_names_uniprotkb": "Smim24; 2210404O07Rik", "gene_names_refseq": "2210404O07Rik; Smim24", "protein_names_uniprotkb": "Small integral membrane protein 24", "protein_names_refseq": "small integral membrane protein 24 precursor; transmembrane protein C19orf77 homolog; transmembrane protein HSPC323 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72273)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VG18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z5L6-1", "uniprot_id": [ { "id": "S18B1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z5L6", "type": "external" } ], "mass": 49009.0, "length": 459, "protein_name": "MFS-type transporter SLC18B1", "gene_name": "Slc18b1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc18b1; 1110021L09Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "MFS-type transporter SLC18B1; Solute carrier family 18 member B1; VPAT; Vesicular polyamine transporter", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "19697161;21750661;25355561;25428506;28082679;31800589", "class_list": "", "function": "Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (By similarity). Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (By similarity) (PubMed:31800589). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (PubMed:28082679)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015311 monoamine:proton antiporter activity;GO:0015312 polyamine:proton antiporter activity", "go_cellular_component": "GO:0030667 secretory granule membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0000296 spermine transport;GO:0051610 serotonin uptake;GO:0015848 spermidine transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3Z5L6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R043-1", "uniprot_id": [ { "id": "SIM29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R043", "type": "external" } ], "mass": 11553.0, "length": 102, "protein_name": "Small integral membrane protein 29", "gene_name": "Smim29", "organism": "Mouse", "refseq_name": "small integral membrane protein 29 isoform 1", "refseq_ac": [ { "id": "NP_001002895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002895", "type": "external" } ], "gene_names_uniprotkb": "Smim29; AI413582", "gene_names_refseq": "Smim29", "protein_names_uniprotkb": "Small integral membrane protein 29", "protein_names_refseq": "small integral membrane protein 29 isoform 1; uncharacterized protein C6orf1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:106672)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2N7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R043-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQS1-1", "uniprot_id": [ { "id": "SCMC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQS1", "type": "external" } ], "mass": 52497.0, "length": 467, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A23", "gene_name": "Slc25a23", "organism": "Mouse", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 1", "refseq_ac": [ { "id": "NP_080153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080153", "type": "external" } ], "gene_names_uniprotkb": "Slc25a23; Scamc3", "gene_names_refseq": "2310067G05Rik; SCaMC-3; Slc25a23", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A23; SCaMC-3; Short calcium-binding mitochondrial carrier protein 3; Solute carrier family 25 member 23", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-3; mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 1; mitochondrial adenyl nucleotide antiporter SLC25A23; short calcium-binding mitochondrial carrier protein 3; small calcium-binding mitochondrial carrier protein 3; solute carrier family 25 member 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:66972)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15054102;21750661;23344948;25716855;33300544;34428180", "class_list": "", "function": "Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways. Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides., [UniProtKB, UniProtKB]; Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3, [RefSeq, PubMed]; SCaMC-3 KO neurons have higher vulnerability to in vitro excitotoxicity, and SCaMC-3 KO mice are more susceptible to kainate-induced seizures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0000295 adenine nucleotide transmembrane transporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0140988 ADP:phosphate antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0015866 ADP transport;GO:0036444 calcium import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6GQS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6XZJ7-1", "uniprot_id": [ { "id": "SAM15_MOUSE", "url": "https://www.uniprot.org/uniprot/F6XZJ7", "type": "external" } ], "mass": 70457.0, "length": 620, "protein_name": "Sterile alpha motif domain-containing protein 15", "gene_name": "Samd15", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 15", "refseq_ac": [ { "id": "NP_001277217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277217", "type": "external" } ], "gene_names_uniprotkb": "Samd15; Gm263", "gene_names_refseq": "Gm263; Samd15", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 15; SAM domain-containing protein 15", "protein_names_refseq": "SAM domain-containing protein 15; sterile alpha motif domain-containing protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:238333)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6XZJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4LDG0-1", "uniprot_id": [ { "id": "S27A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4LDG0", "type": "external" } ], "mass": 76203.0, "length": 689, "protein_name": "Long-chain fatty acid transport protein 5", "gene_name": "Slc27a5", "organism": "Mouse", "refseq_name": "long-chain fatty acid transport protein 5", "refseq_ac": [ { "id": "NP_033538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033538", "type": "external" } ], "gene_names_uniprotkb": "Slc27a5; Acsb; Acsvl6; Fatp5; Vlacsr", "gene_names_refseq": "FACVL3; FATP5; Slc27a5; VLCS-H2; VLCSH2; Vlacsr", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 5; 6.2.1.-; 6.2.1.3; 6.2.1.7; BA-CoA ligase; BACS; BAL; Bile acid-CoA ligase; Bile acyl-CoA synthetase; Cholate--CoA ligase; FATP-5; Fatty acid transport protein 5; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 5; VLACS-related; VLACSR; Very long-chain acyl-CoA synthetase-related protein", "protein_names_refseq": "BA-CoA ligase; BACS; BAL; FATP-5; VLACS-related; bile acid-CoA ligase; bile acyl-CoA synthetase; cholate--CoA ligase; fatty acid transport protein 5; long-chain fatty acid transport protein 5; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 5; very long-chain acyl-CoA synthetase-related protein; very long-chain acyl-Coenzyme A dehydrogenase synthase related", "tax_id": 10090, "disease": "", "pathway": " (mmu:26459); (R-MMU-159418); (R-MMU-193368); (R-MMU-193775)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "11980911;16618416;16618417;21750661;30084848;34428180;37453647;37957540;38358323;9642112;9671728", "class_list": "", "function": "FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma., [RefSeq, PubMed]; Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid., [RefSeq, PubMed]; Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:16618416). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:16618417). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (PubMed:16618416, PubMed:16618417)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6C1;O88694;Q91VD5", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009925 basal plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006699 bile acid biosynthetic process;GO:0046951 ketone body biosynthetic process;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q4LDG0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54926-1", "uniprot_id": [ { "id": "SIVA_MOUSE", "url": "https://www.uniprot.org/uniprot/O54926", "type": "external" } ], "mass": 18770.0, "length": 175, "protein_name": "Apoptosis regulatory protein Siva", "gene_name": "Siva1", "organism": "Mouse", "refseq_name": "apoptosis regulatory protein Siva isoform 2", "refseq_ac": [ { "id": "NP_001155209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155209", "type": "external" } ], "gene_names_uniprotkb": "Siva1; Siva", "gene_names_refseq": "CD27bp; Siva1; Siva", "protein_names_uniprotkb": "Apoptosis regulatory protein Siva; CD27-binding protein; CD27BP", "protein_names_refseq": "CD27-binding protein; Cd27 binding protein; apoptosis regulatory protein Siva isoform 2; apoptosis regulatory protein Siva", "tax_id": 10090, "disease": "", "pathway": " (mmu:30954)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10597319;10756043;12478477;15105421;31164717;31219806;32015347;9177220", "class_list": "", "function": "Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity)., [UniProtKB, PubMed]; SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Publication Status: Online-Only, [RefSeq, PubMed]; Siva plays a critical role in mouse embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6J2;Q921I8;Q9CWL1;Q9R1Q0;Q9R1Q1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001618 virus receptor activity;GO:0005175 CD27 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0097191 extrinsic apoptotic signaling pathway;GO:0097193 intrinsic apoptotic signaling pathway;GO:0006924 activation-induced cell death of T cells", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54926-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55192-1", "uniprot_id": [ { "id": "SC6A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O55192", "type": "external" } ], "mass": 69255.0, "length": 617, "protein_name": "Sodium-dependent noradrenaline transporter", "gene_name": "Slc6a2", "organism": "Mouse", "refseq_name": "sodium-dependent noradrenaline transporter", "refseq_ac": [ { "id": "NP_033235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033235", "type": "external" } ], "gene_names_uniprotkb": "Slc6a2", "gene_names_refseq": "NE-T; NET; Slc6a2; Slc6a5", "protein_names_uniprotkb": "Sodium-dependent noradrenaline transporter; NET; Norepinephrine transporter; Solute carrier family 6 member 2", "protein_names_refseq": "NE transporter; norepinephrine transporter; sodium-dependent noradrenaline transporter; solute carrier family 6 member 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); autism spectrum disorder (Disease Ontology:DOID:0060041); classic dopamine transporter deficiency syndrome (Disease Ontology:DOID:0070489); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); heart conduction disease (Disease Ontology:DOID:10273); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); neurocirculatory asthenia (Disease Ontology:DOID:11569); depressive disorder (Disease Ontology:DOID:1596); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (mmu:20538); (R-MMU-442660)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10769386;16269905;19545450;23580201;25724654;30084848;34428180;9603188", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:16269905, PubMed:23580201). Is responsible for norepinephrine reuptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (PubMed:10769386, PubMed:23580201). Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6QU62", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005328 neurotransmitter:sodium symporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030672 synaptic vesicle membrane;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0015844 monoamine transport;GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus;GO:0048265 response to pain", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55192-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88520-1", "uniprot_id": [ { "id": "SHOC2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88520", "type": "external" } ], "mass": 64893.0, "length": 582, "protein_name": "Leucine-rich repeat protein SHOC-2", "gene_name": "Shoc2", "organism": "Mouse", "refseq_name": "leucine-rich repeat protein SHOC-2", "refseq_ac": [ { "id": "NP_001161977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161977", "type": "external" } ], "gene_names_uniprotkb": "Shoc2", "gene_names_refseq": "Shoc2; Sur8; mKIAA0862", "protein_names_uniprotkb": "Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein sur-8 homolog", "protein_names_refseq": "Ras-binding protein SUR-8; leucine-rich repeat protein SHOC-2; protein soc-2 homolog; protein sur-8 homolog; soc-2 (suppressor of clear) homolog; soc-2-like protein; suppressor of clear, C. elegans, homolog of", "tax_id": 10090, "disease": "RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome-like disorder with loose anagen hair (Disease Ontology:DOID:0080691); Noonan syndrome-like disorder with loose anagen hair 1 (Disease Ontology:DOID:0080692); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:56392); (R-MMU-5673000)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16301319;16682971;21750661;34428180;36210013;36543126;37170083;9674433", "class_list": "", "function": "Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Erbin has a regulatory role in the Ras-Raf-MEK pathway and may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction, [RefSeq, PubMed]; SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus., [RefSeq, PubMed]; The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJH6;Q8BVL0;Q91VH8", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0071378 cellular response to growth hormone stimulus;GO:0010976 positive regulation of neuron projection development;GO:0035556 intracellular signal transduction;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88520-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88909-1", "uniprot_id": [ { "id": "S22A8_MOUSE", "url": "https://www.uniprot.org/uniprot/O88909", "type": "external" } ], "mass": 59246.0, "length": 537, "protein_name": "Organic anion transporter 3", "gene_name": "Slc22a8", "organism": "Mouse", "refseq_name": "organic anion transporter 3 isoform 1", "refseq_ac": [ { "id": "NP_001158106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158106", "type": "external" } ], "gene_names_uniprotkb": "Slc22a8; Oat3; Roct", "gene_names_refseq": "Oat3; Roct; Slc22a8", "protein_names_uniprotkb": "Organic anion transporter 3; Organic anion/dicarboxylate exchanger; Reduced in osteosclerosis transporter; Roct; Solute carrier family 22 member 8; mOat3", "protein_names_refseq": "organic anion transporter 3 isoform 1; organic anion transporter 3; organic anion/dicarboxylate exchanger; reduced in osteosclerosis transporter; solute carrier family 22, member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:19879); (R-MMU-561048)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10087192;12011098;15075193;15100168;15944205;17220594;21325432;23389457;29412698;31896576;32271169;33757768;34428180", "class_list": "", "function": "Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3., [RefSeq, PubMed]; Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (By similarity). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:17220594). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:12011098, PubMed:15075193, PubMed:17220594, PubMed:21325432). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange. Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (By similarity). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (PubMed:12011098). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (PubMed:15100168, PubMed:17220594). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB) (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; OAT3 increases the glucosuric effect of empagliflozin, which may relate to the partial overlap of its localization with SGLT2 and thus OAT3-mediated tubular secretion of empagliflozin in the early proximal tubule., [RefSeq, PubMed]; Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter), [RefSeq, PubMed]; Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZF9;Q8CCX3;Q8CFH5;Q91WJ9", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0005080 protein kinase C binding;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0034635 glutathione transport;GO:0006811 monoatomic ion transport;GO:0009636 response to toxic substance;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88909-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70178-1", "uniprot_id": [ { "id": "SIX5_MOUSE", "url": "https://www.uniprot.org/uniprot/P70178", "type": "external" } ], "mass": 73717.0, "length": 719, "protein_name": "Homeobox protein SIX5", "gene_name": "Six5", "organism": "Mouse", "refseq_name": "homeobox protein SIX5", "refseq_ac": [ { "id": "NP_035513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035513", "type": "external" } ], "gene_names_uniprotkb": "Six5; Dmahp", "gene_names_refseq": "Dmahp; MDMAHP; Six5; TrexBF", "protein_names_uniprotkb": "Homeobox protein SIX5; DM locus-associated homeodomain protein homolog; Sine oculis homeobox homolog 5", "protein_names_refseq": "DM locus-associated homeodomain protein homolog; homeobox protein SIX5; sine oculis homeobox homolog 5; sine oculis-related homeobox 5 homolog", "tax_id": 10090, "disease": "branchiootorenal syndrome 2 (Disease Ontology:DOID:0111424); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); branchiootorenal syndrome (Disease Ontology:DOID:14702)", "pathway": " (mmu:20475)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10490620;11978764;12215533;25428506;27224259;30084848;30237319;30779550;31219806;31599954;34428180;35820727;37828378;8814301", "class_list": "", "function": "Six4 and Six5 are required for growth and morphological change of the primary abdominal wall. Publication Status: Online-Only, [RefSeq, PubMed]; The results indicated that low Six4 and Six5 gene dosage improved dystrophic phenotypes of Dmd(mdx) /Y mice by enhancing muscle regeneration, and suggested that SIX4 and SIX5 are potentially useful de novo targets in therapeutic applications against muscle disorders, including DMD., [RefSeq, PubMed]; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P70178-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70390-1", "uniprot_id": [ { "id": "SHOX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70390", "type": "external" } ], "mass": 34905.0, "length": 331, "protein_name": "Short stature homeobox protein 2", "gene_name": "Shox2", "organism": "Mouse", "refseq_name": "short stature homeobox protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001289286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289286", "type": "external" } ], "gene_names_uniprotkb": "Shox2; Og12x; Prx3", "gene_names_refseq": "6330543G17Rik; OG12; Og12x; Prx3; SHOT; Shox2", "protein_names_uniprotkb": "Short stature homeobox protein 2; Homeobox protein Og12X; OG-12; Paired family homeodomain protein Prx3", "protein_names_refseq": "OG-12; homeobox protein Og12X; paired family homeodomain protein Prx3; short stature homeobox 2; short stature homeobox protein 2 isoform 2; short stature homeobox protein 2", "tax_id": 10090, "disease": "Leri-Weill dyschondrosteosis (Disease Ontology:DOID:0060847); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:20429)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10749976;21750661;8855241;9371788;9466998;9482898", "class_list": "", "function": "May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70369", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0003170 heart valve development;GO:0060931 sinoatrial node cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70390-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05A13-1", "uniprot_id": [ { "id": "S16C6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05A13", "type": "external" } ], "mass": 35158.0, "length": 316, "protein_name": "Short-chain dehydrogenase/reductase family 16C member 6", "gene_name": "Sdr16c6", "organism": "Mouse", "refseq_name": "short-chain dehydrogenase/reductase family 16C member 6", "refseq_ac": [ { "id": "NP_001074179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074179", "type": "external" } ], "gene_names_uniprotkb": "Sdr16c6", "gene_names_refseq": "4833413O15Rik; Gm423; Sdr16c6", "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase family 16C member 6; 1.1.1.-", "protein_names_refseq": "short-chain dehydrogenase/reductase family 16C member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:242286)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;31562240;34428180;37075844", "class_list": "", "function": "SDR16C5 and SDR16C6 enzymes are not critical for survival but are responsible for most of the retinol dehydrogenase activity in skin, essential for the regulation of the hair-follicle cycle, and required for the maintenance of both sebaceous and meibomian glands, [RefSeq, PubMed]; Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005811 lipid droplet", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q05A13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TAA7-1", "uniprot_id": [ { "id": "S11IP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TAA7", "type": "external" } ], "mass": 118005.0, "length": 1072, "protein_name": "Serine/threonine-protein kinase 11-interacting protein", "gene_name": "Stk11ip", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 11-interacting protein", "refseq_ac": [ { "id": "NP_082162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082162", "type": "external" } ], "gene_names_uniprotkb": "Stk11ip; Lip1; Lkb1ip", "gene_names_refseq": "1200014D22Rik; LIP1; LKB1IP; Stk11ip", "protein_names_uniprotkb": "Serine/threonine-protein kinase 11-interacting protein; LKB1-interacting protein 1", "protein_names_refseq": "LKB1-interacting protein 1; serine/threonine-protein kinase 11-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71728); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11741830;18250455;20173027;20974850;21183079;25428507;26495903;33486894;34428180;35365663;35820727", "class_list": "", "function": "LKB1 and LIP1 provide negative control of TGFbeta signaling., [RefSeq, PubMed]; LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. Erratum:[J Cell Mol Med. 2022 Mar;26(5):1722-1723. doi: 10.1111/jcmm.17194. PMID: 35253382], [RefSeq, PubMed]; May regulate STK11/LKB1 function by controlling its subcellular localization., [UniProtKB]; Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7J8;Q9DBT7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3TAA7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U276-1", "uniprot_id": [ { "id": "SDHF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U276", "type": "external" } ], "mass": 13142.0, "length": 118, "protein_name": "Succinate dehydrogenase assembly factor 1, mitochondrial", "gene_name": "Sdhaf1", "organism": "Mouse", "refseq_name": "succinate dehydrogenase assembly factor 1, mitochondrial", "refseq_ac": [ { "id": "NP_001028312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028312", "type": "external" } ], "gene_names_uniprotkb": "Sdhaf1; Lyrm8", "gene_names_refseq": "0610010E21Rik; Lyrm8; Sdhaf1", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 1, mitochondrial; LYR motif-containing protein 8; SDH assembly factor 1; SDHAF1", "protein_names_refseq": "LYR motif-containing protein 8; SDH assembly factor 1; succinate dehydrogenase assembly factor 1, mitochondrial", "tax_id": 10090, "disease": "mitochondrial complex II deficiency (Disease Ontology:DOID:0060537)", "pathway": " (mmu:68332); (R-MMU-9854311)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "26388266;36288343", "class_list": "", "function": "Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH), implicating alteration in SDH activity as causative of the injury., [RefSeq, PubMed]; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVF8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3U276-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHH2-1", "uniprot_id": [ { "id": "S22AN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHH2", "type": "external" } ], "mass": 74325.0, "length": 689, "protein_name": "Solute carrier family 22 member 23", "gene_name": "Slc22a23", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 23 isoform 1", "refseq_ac": [ { "id": "NP_001028339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028339", "type": "external" } ], "gene_names_uniprotkb": "Slc22a23", "gene_names_refseq": "3110004L20Rik; Slc22a23", "protein_names_uniprotkb": "Solute carrier family 22 member 23", "protein_names_refseq": "solute carrier family 22 member 23 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73102)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17714910;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPT5", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UHH2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPR0-1", "uniprot_id": [ { "id": "SHSA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPR0", "type": "external" } ], "mass": 25602.0, "length": 238, "protein_name": "Protein shisa-3 homolog", "gene_name": "Shisa3", "organism": "Mouse", "refseq_name": "protein shisa-3 homolog precursor", "refseq_ac": [ { "id": "NP_001028587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028587", "type": "external" } ], "gene_names_uniprotkb": "Shisa3", "gene_names_refseq": "D830007B15Rik; Shisa3", "protein_names_uniprotkb": "Protein shisa-3 homolog", "protein_names_refseq": "protein shisa-3 homolog precursor; protein shisa-3 homolog; shisa homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:330096)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17481602;21750661;25036006;25428506;31222549;31582141", "class_list": "", "function": "Here appears to be a redundancy in the function of Shisa3 in bone development, likely with other Shisa family members., [RefSeq, PubMed]; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling., [UniProtKB, PubMed]; SHISA3 is normally expressed in the developing heart and is up-regulated in pathological remodeling., [RefSeq, PubMed]; Shisa3 acts as a tumor suppressor by acceleration of beta-catenin degradation. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201312-2256OC, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5V3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UPR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504N2-1", "uniprot_id": [ { "id": "S22AF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q504N2", "type": "external" } ], "mass": 60286.0, "length": 544, "protein_name": "Solute carrier family 22 member 15", "gene_name": "Slc22a15", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 15", "refseq_ac": [ { "id": "NP_001034460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034460", "type": "external" } ], "gene_names_uniprotkb": "Slc22a15", "gene_names_refseq": "2610034P21Rik; 4930477M19; A530052I06Rik; Slc22a15", "protein_names_uniprotkb": "Solute carrier family 22 member 15", "protein_names_refseq": "solute carrier family 22 (organic cation transporter), member 15; solute carrier family 22 member 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:242126); (R-MMU-549127)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;33124720;34428180", "class_list": "", "function": "Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Substrate selectivity and the transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remain to be elucidated., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A7MCW2;F8WJ00;Q8CDR3", "ec_number_list": [], "go_molecular_function": "GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q504N2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61079-1", "uniprot_id": [ { "id": "SIM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61079", "type": "external" } ], "mass": 72513.0, "length": 657, "protein_name": "Single-minded homolog 2", "gene_name": "Sim2", "organism": "Mouse", "refseq_name": "single-minded homolog 2", "refseq_ac": [ { "id": "NP_035507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035507", "type": "external" } ], "gene_names_uniprotkb": "Sim2", "gene_names_refseq": "Sim2; bHLHe15", "protein_names_uniprotkb": "Single-minded homolog 2; SIM transcription factor; mSIM", "protein_names_refseq": "SIM transcription factor; mSIM; single-minded 2; single-minded homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20465)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;8561800;8661114;8661115;8812055;9020169", "class_list": "", "function": "Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35391;Q61046;Q61904", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61079-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61672-1", "uniprot_id": [ { "id": "S29A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61672", "type": "external" } ], "mass": 50255.0, "length": 456, "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "Slc29a2", "organism": "Mouse", "refseq_name": "equilibrative nucleoside transporter 2", "refseq_ac": [ { "id": "NP_031880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031880", "type": "external" } ], "gene_names_uniprotkb": "Slc29a2; Der12; Ent2; Hnp36", "gene_names_refseq": "Der12; Ent2; Hnp36; Slc29a2; mENT2", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 2; 36 kDa hydrophobic nucleolar protein; 36 kDa nucleolar protein HNP36; Delayed-early response protein 12; Equilibrative NBMPR-insensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; mENT2", "protein_names_refseq": "36 kDa hydrophobic nucleolar protein; 36 kDa nucleolar protein HNP36; delayed early response gene 12; delayed-early response protein 12; equilibrative NBMPR-insensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; equilibrative nucleoside transporter 2; nucleoside transporter, ei-type; solute carrier family 29 member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13340); (R-MMU-83936); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11085929;21750661;34058310;36669543;37498500;7639753", "class_list": "", "function": "Amelioration of lipopolysaccharide-induced memory impairment in equilibrative nucleoside transporter-2 knockout mice is accompanied by the changes in glutamatergic pathways., [RefSeq, PubMed]; Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent, passive transporter. Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine. Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites. Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier. Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease., [RefSeq, PubMed]; The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIT8", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015205 nucleobase transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031965 nuclear membrane;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015861 cytidine transport;GO:0015858 nucleoside transport;GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61672-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64689-1", "uniprot_id": [ { "id": "SIA8C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64689", "type": "external" } ], "mass": 43942.0, "length": 380, "protein_name": "Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3", "gene_name": "St8sia3", "organism": "Mouse", "refseq_name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3", "refseq_ac": [ { "id": "NP_033208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033208", "type": "external" } ], "gene_names_uniprotkb": "St8sia3; Siat8c", "gene_names_refseq": "ST8SiaIII; Siat8c; St8sia3", "protein_names_uniprotkb": "Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3; 2.4.3.-; 2.4.3.8; Alpha-2,8-sialyltransferase 8C; Alpha-2,8-sialyltransferase III; Ganglioside GD3 synthase ST8SIA3; SIAT8-C; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; ST8SiaIII; Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase; Sialyltransferase 8C; Sialyltransferase St8Sia III", "protein_names_refseq": "SIAT8-C; alpha-2,8-sialyltransferase 8C; alpha-2,8-sialyltransferase III; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3; ganglioside GD3 synthase ST8SIA3; sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase; sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; sialyltransferase 8 (alpha-2, 8-sialyltransferase) C; sialyltransferase 8C; sialyltransferase St8Sia III; sialytransferase St8Sia III", "tax_id": 10090, "disease": "", "pathway": " (mmu:20451); (R-MMU-4085001); (R-MMU-975577)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;22038478;30899004;31455764;35820727;7782326", "class_list": "glycogene;glycosyltransferase", "function": "A significant decrease in ST8Sia III gene expression was found in the cerebellum of senile animals., [RefSeq, PubMed]; Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages (PubMed:7782326). Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS-glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids, such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans (PubMed:7782326). However, it is much more specific to N-linked oligosaccharides of glycoproteins than glycosphingolipids (PubMed:7782326). 2,3-sialylparagloboside served as the best acceptor substrate among the glycolipids (PubMed:7782326). alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc and monosialyl and disialyl N-acetyllactosamines are the best acceptor substrates among glycoproteins (By similarity). May play critical role in the striatum by mediating the formation of disialylated and trisialylated terminal glycotopes on N- and O-glycans of specific striatal proteins, regulating their distribution in lipid rafts, affecting their interaction with other binding partners, and subsequently modulating striatal functions (PubMed:31455764)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6DIB7", "ec_number_list": [ { "id": "2.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.-", "type": "external" }, { "id": "2.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.-", "type": "external" }, { "id": "2.4.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.8", "type": "external" } ], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0042802 identical protein binding;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0009100 glycoprotein metabolic process;GO:0006491 N-glycan processing;GO:0097503 sialylation", "synthesized_glycan_count": 21, "hit_score": 1.6, "record_id": "Q64689-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A4L0-1", "uniprot_id": [ { "id": "S22AD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A4L0", "type": "external" } ], "mass": 60724.0, "length": 551, "protein_name": "Solute carrier family 22 member 13", "gene_name": "Slc22a13", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 13", "refseq_ac": [ { "id": "NP_598741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598741", "type": "external" } ], "gene_names_uniprotkb": "Slc22a13; Orctl3", "gene_names_refseq": "OAT10; OCTL1; OCTL3; ORCTL3; Slc22a13", "protein_names_uniprotkb": "Solute carrier family 22 member 13; OAT10; ORCTL-3; Organic anion transporter 10; Organic cation transporter-like 3", "protein_names_refseq": "ORCTL-3; organic anion transporter 10; organic cation transporter-like 3; solute carrier family 22 member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:102570); (R-MMU-196807)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "35144162", "class_list": "", "function": "Anion antiporter that mediates the transport of orotate and nicotinate in exchange for organic or inorganic anions (PubMed:35144162). Translocates orotate across the apical membrane of proximal tubule epithelial cells. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:35144162). Orotate transport is Cl(-)-dependent (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QP74;Q8VC89", "ec_number_list": [], "go_molecular_function": "GO:0015143 urate transmembrane transporter activity;GO:0090416 nicotinate transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0045922 negative regulation of fatty acid metabolic process;GO:2001142 nicotinate transport;GO:0015747 urate transport;GO:0002854 positive regulation of T cell mediated cytotoxicity directed against tumor cell target", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6A4L0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6S5I3-1", "uniprot_id": [ { "id": "S115A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6S5I3", "type": "external" } ], "mass": 12870.0, "length": 108, "protein_name": "Protein S100-A15A", "gene_name": "S100a15a", "organism": "Mouse", "refseq_name": "protein S100-A15A", "refseq_ac": [ { "id": "NP_955454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955454", "type": "external" } ], "gene_names_uniprotkb": "S100a15a; S100a15; S100a7a; S100a7", "gene_names_refseq": "Gm1020; S100A7L1; S100A7f; S100a15a; S100a15; S100a17l1; S100a7a", "protein_names_uniprotkb": "Protein S100-A15A; Protein S100-A7A; S100 calcium-binding protein A15A; S100 calcium-binding protein A7A", "protein_names_refseq": "S100 calcium binding protein A15; S100 calcium binding protein A7-like 1; S100 calcium-binding protein A15A; protein S100-A15A", "tax_id": 10090, "disease": "psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:381493)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15717926;16528363;22158945;23499548;31044023", "class_list": "", "function": "Data show that hS100A7 and mS100a7a15 overexpression induce proliferation and expression of inflammatory cytokines/chemokines., [RefSeq, PubMed]; The regulation, expression pattern and crosslinking of mS100A15 are consistent with the characteristics of the human orthologs, providing a valid surrogate model to study changes in these proteins associated with cutaneous pathologies., [RefSeq, PubMed]; These results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. S00A7 Publication Status: Online-Only, [RefSeq, PubMed]; Visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6S5I3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M747-1", "uniprot_id": [ { "id": "S2B24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M747", "type": "external" } ], "mass": 12535.0, "length": 112, "protein_name": "Secretoglobin family 2B member 24", "gene_name": "Scgb2b24", "organism": "Mouse", "refseq_name": "secretoglobin family 2B member 24 precursor", "refseq_ac": [ { "id": "NP_803229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803229", "type": "external" } ], "gene_names_uniprotkb": "Scgb2b24; Abpz", "gene_names_refseq": "Abpbg24; Abpz; C2b; Scgb2b24; Scgb2b3", "protein_names_uniprotkb": "Secretoglobin family 2B member 24; Allergen dI chain C2B; Androgen-binding protein zeta; Lacrimal androgen-binding protein zeta", "protein_names_refseq": "allergen dI chain C2B; androgen binding protein zeta; lacrimal androgen-binding protein zeta; secretoglobin family 2B member 24 precursor; secretoglobin, family 2B, member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:233090)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12406855;15623751", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M747-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSK2-1", "uniprot_id": [ { "id": "SEZ6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSK2", "type": "external" } ], "mass": 107433.0, "length": 991, "protein_name": "Seizure protein 6", "gene_name": "Sez6", "organism": "Mouse", "refseq_name": "seizure protein 6 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001278154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278154", "type": "external" } ], "gene_names_uniprotkb": "Sez6; Kiaa4158", "gene_names_refseq": "BSRP-C; D11Bhm177e; Sez6; sez-6", "protein_names_uniprotkb": "Seizure protein 6; BSRP-C; Brain-specific receptor-like protein C; SEZ-6", "protein_names_refseq": "brain-specific receptor-like protein C; seizure protein 6 isoform 2 precursor; seizure protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:20370)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12351182;16814779;18031681;21750661;30899004;31711114;32567721;34302009;36368155;7488116;7723619", "class_list": "", "function": "BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory. Publication Status: Online-Only, [RefSeq, PubMed]; Differential brain expression pattern of Sez6 alternative splicing isoform with deleted transmembrane domain., [RefSeq, PubMed]; Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties., [RefSeq, PubMed]; May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity., [UniProtKB, PubMed]; Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT53;Q62223;Q62224;Q62269;Q7TPC9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0060079 excitatory postsynaptic potential;GO:1990051 activation of protein kinase C activity;GO:0021680 cerebellar Purkinje cell layer development;GO:2000171 negative regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TSK2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TST3-1", "uniprot_id": [ { "id": "SAM10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TST3", "type": "external" } ], "mass": 22761.0, "length": 202, "protein_name": "Sterile alpha motif domain-containing protein 10", "gene_name": "Samd10", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 10 isoform 1", "refseq_ac": [ { "id": "NP_766264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766264", "type": "external" } ], "gene_names_uniprotkb": "Samd10", "gene_names_refseq": "D930033N23Rik; E130318E08; Samd10", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 10; SAM domain-containing protein 10", "protein_names_refseq": "SAM domain-containing protein 10; sterile alpha motif domain-containing protein 10 isoform 1; sterile alpha motif domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:229011)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TST3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VA5-1", "uniprot_id": [ { "id": "S3TC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VA5", "type": "external" } ], "mass": 145144.0, "length": 1289, "protein_name": "SH3 domain and tetratricopeptide repeat-containing protein 2", "gene_name": "Sh3tc2", "organism": "Mouse", "refseq_name": "SH3 domain and tetratricopeptide repeat-containing protein 2", "refseq_ac": [ { "id": "NP_766216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766216", "type": "external" } ], "gene_names_uniprotkb": "Sh3tc2; Kiaa1985", "gene_names_refseq": "D430044G18Rik; Sh3tc2", "protein_names_uniprotkb": "SH3 domain and tetratricopeptide repeat-containing protein 2", "protein_names_refseq": "SH3 domain and tetratricopeptide repeat-containing protein 2; SH3 domain and tetratricopeptide repeats-containing protein 2", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4C (Disease Ontology:DOID:0110183)", "pathway": " (mmu:225608)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19805030;20826437;21750661;23553667;25428506;30084848;34428180", "class_list": "", "function": "Is involved in nerve myelination and is required for the integrity of nodes of Ranvier (PubMed:19805030). It probably functions as a Rab effector in the regulation of endocytic recycling (By similarity)., [UniProtKB, PubMed, UniProtKB]; Our data indicate that the SH3TC2/Rab11 interaction is relevant for peripheral nerve pathophysiology and place endosomal recycling on the list of cellular mechanisms involved in Schwann cell myelination., [RefSeq, PubMed]; Sh3tc2 is specifically expressed in Schwann cells and localizes to the plasma membrane and to the perinuclear endocytic recycling compartment in a mouse experimental model. Erratum:[Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15305. Kleine, Henning [added]; Luscher, Bernhard [added]], [RefSeq, PubMed]; The results of this study results indicate that the molecular mechanism for the axonal size sensing is disturbed in Sh3tc2-deficient myelinating Schwann cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWH2;Q8BXB8;Q8C0G6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0022011 myelination in peripheral nervous system;GO:0032287 peripheral nervous system myelin maintenance;GO:0033157 regulation of intracellular protein transport;GO:1901184 regulation of ERBB signaling pathway;GO:2001135 regulation of endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80VA5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGF8-1", "uniprot_id": [ { "id": "S35D3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGF8", "type": "external" } ], "mass": 44917.0, "length": 422, "protein_name": "Solute carrier family 35 member D3", "gene_name": "Slc35d3", "organism": "Mouse", "refseq_name": "solute carrier family 35 member D3", "refseq_ac": [ { "id": "NP_083805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083805", "type": "external" } ], "gene_names_uniprotkb": "Slc35d3; Frcl1", "gene_names_refseq": "6230421J19Rik; Frcl1; Slc35d3", "protein_names_uniprotkb": "Solute carrier family 35 member D3; Fringe connection-like protein 1", "protein_names_refseq": "frc, fringe-like 1; fringe connection-like protein 1; solute carrier family 35 member D3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76157)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17062724;22611153;24550737;27171858;34269178;37996411", "class_list": "glycogene", "function": "Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons (PubMed:27171858). Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling (PubMed:24550737)., [UniProtKB, PubMed, PubMed]; Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles (PubMed:34269178). It is involved in platelet dense granules maturation (PubMed:17062724, PubMed:22611153)., [UniProtKB, PubMed, PubMed, PubMed]; SLC35D3 is depleted in platelets from 2 of 3 Hermansky-Pudlak syndrome models and, when expressed ectopically in melanocytes, SLC35D3 localizes to melanosomes in a manner requiring a HPS-associated protein complex, [RefSeq, PubMed]; SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Slc35d3 specifically regulates the contents of platelet-dense granules. Unlike HPS or CHS genes, it has no apparent effect on other lysosome-related organelles such as melanosomes or lysosomes, [RefSeq, PubMed]; That SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXD4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0015297 antiporter activity;GO:0005460 UDP-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0097009 energy homeostasis;GO:0010508 positive regulation of autophagy;GO:0060155 platelet dense granule organization;GO:0070863 positive regulation of protein exit from endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BGF8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGH2-1", "uniprot_id": [ { "id": "SAM50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGH2", "type": "external" } ], "mass": 51864.0, "length": 469, "protein_name": "Sorting and assembly machinery component 50 homolog", "gene_name": "Samm50", "organism": "Mouse", "refseq_name": "sorting and assembly machinery component 50 homolog", "refseq_ac": [ { "id": "NP_848729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848729", "type": "external" } ], "gene_names_uniprotkb": "Samm50", "gene_names_refseq": "1110030L07Rik; Samm50", "protein_names_uniprotkb": "Sorting and assembly machinery component 50 homolog", "protein_names_refseq": "sorting and assembly machinery component 50 homolog", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:68653); (R-MMU-9013404)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21081504;31219806;34428180;36210013;37507081;40684658", "class_list": "", "function": "Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIL3;Q3TTG7;Q3TWD3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0042407 cristae formation;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHJ6-1", "uniprot_id": [ { "id": "SERC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHJ6", "type": "external" } ], "mass": 51831.0, "length": 461, "protein_name": "Serine incorporator 5", "gene_name": "Serinc5", "organism": "Mouse", "refseq_name": "serine incorporator 5", "refseq_ac": [ { "id": "NP_766176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766176", "type": "external" } ], "gene_names_uniprotkb": "Serinc5; Aigp3", "gene_names_refseq": "A130038L21Rik; AIGP3; Serinc5; TPO1", "protein_names_uniprotkb": "Serine incorporator 5; AIGP-3; Axotomy-induced glycoprotein 3", "protein_names_refseq": "AIGP-3; axotomy-induced glycoprotein 3; serine incorporator 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:218442); (R-MMU-977347)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12486168;16405874;30355687;32665269", "class_list": "", "function": "Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SERINC5 Potently Restricts Retrovirus Infection In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Study shows that glycoGag interacts with Ser5 in live cells and internalizes Ser5 via receptor-mediated endocytosis. Ser5 is polyubiquitinated and relocalized to endosomes and lysosomes for massive destruction. In addition to the previously identified tyrosine-based sorting signal, results find two more important residues for Ser5 relocalization and downregulation. Publication Status: Online-Only, [RefSeq, PubMed]; TPO1 may play role in myelin formation via Fyn kinase activation in central and peripheral nervous systems., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZH8;Q8CHM0", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity;GO:0010698 acetyltransferase activator activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042552 myelination;GO:0017121 plasma membrane phospholipid scrambling;GO:0008654 phospholipid biosynthetic process;GO:0006658 phosphatidylserine metabolic process;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BHJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI29-1", "uniprot_id": [ { "id": "SARG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI29", "type": "external" } ], "mass": 65092.0, "length": 606, "protein_name": "Specifically androgen-regulated gene protein", "gene_name": "Sarg", "organism": "Mouse", "refseq_name": "specifically androgen-regulated gene protein isoform 1", "refseq_ac": [ { "id": "NP_808272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808272", "type": "external" } ], "gene_names_uniprotkb": "Sarg", "gene_names_refseq": "AA986860; E030025M07; Sarg", "protein_names_uniprotkb": "Specifically androgen-regulated gene protein", "protein_names_refseq": "specifically androgen-regulated gene protein isoform 1; specifically androgen-regulated gene protein; specifically androgen-regulated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:212439)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Putative androgen-specific receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VDH0;Q4FZK7;Q8BHU5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BI29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BN82-1", "uniprot_id": [ { "id": "S17A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BN82", "type": "external" } ], "mass": 54369.0, "length": 495, "protein_name": "Sialin", "gene_name": "Slc17a5", "organism": "Mouse", "refseq_name": "sialin isoform b", "refseq_ac": [ { "id": "NP_001263381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263381", "type": "external" } ], "gene_names_uniprotkb": "Slc17a5", "gene_names_refseq": "4631416G20Rik; 4732491M05; AST; ISSD; NSD; SD; SIALIN; SIASD; SLD; Slc17a5; VEAT", "protein_names_uniprotkb": "Sialin; AST; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; Solute carrier family 17 member 5; VEAT; Vesicular excitatory amino acid transporter", "protein_names_refseq": "H(+)/nitrate cotransporter; sialin isoform b; sodium/sialic acid cotransporter; vesicular H(+)/Aspartate-glutamate cotransporter; vesicular excitatory amino acid transporter", "tax_id": 10090, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211); sialuria (Disease Ontology:DOID:3659)", "pathway": " (mmu:235504); (R-MMU-2160916); (R-MMU-4085001); (R-MMU-428643)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "18695252;19144319;20007460;23221336;23889254;25494612;28189729;34428180", "class_list": "glycogene", "function": "Autophagy regulates the stability of sialin, a lysosomal sialic acid transporter., [RefSeq, PubMed]; L-aspartate is exocytotically released from nerve terminals after vesicular accumulation by a transporter other than sialin., [RefSeq, PubMed]; Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (By similarity) (PubMed:18695252). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:20007460). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (By similarity). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (PubMed:18695252, PubMed:23889254)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties., [UniProtKB, UniProtKB]; Sialin possesses dual physiological functions and acts as a vesicular aspartate/glutamate transporter, [RefSeq, PubMed]; The uptake of N-acetylaspartylglutamate into synaptic vesicles depends on sialic acid transporter sialin, SLC17A5., [RefSeq, PubMed]; This study demonstrated that Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE25", "ec_number_list": [], "go_molecular_function": "GO:0015136 sialic acid transmembrane transporter activity;GO:0015293 symporter activity;GO:0042880 D-glucuronate transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0015739 sialic acid transport;GO:0009617 response to bacterium;GO:0006865 amino acid transport;GO:0098700 neurotransmitter loading into synaptic vesicle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BN82-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPX9-1", "uniprot_id": [ { "id": "S15A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPX9", "type": "external" } ], "mass": 64051.0, "length": 578, "protein_name": "Solute carrier family 15 member 3", "gene_name": "Slc15a3", "organism": "Mouse", "refseq_name": "solute carrier family 15 member 3", "refseq_ac": [ { "id": "NP_075531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075531", "type": "external" } ], "gene_names_uniprotkb": "Slc15a3; Ci1; Pht2", "gene_names_refseq": "Ci1; Slc15a3; cI-1", "protein_names_uniprotkb": "Solute carrier family 15 member 3; Peptide transporter 3; Peptide/histidine transporter 2; cAMP-inducible gene 1 protein", "protein_names_refseq": "cAMP inducible gene 1; cAMP-inducible gene 1 protein; peptide transporter 3; peptide/histidine transporter 2; solute carrier family 15 member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:65221); (R-MMU-427975)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11004510;24695226;38374230;39719710", "class_list": "", "function": "Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:24695226, PubMed:39719710). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (PubMed:39719710). Also able to transport carnosine (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:24695226)., [UniProtKB, UniProtKB, PubMed, PubMed]; SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9WU80", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0071916 dipeptide transmembrane transporter activity;GO:0015647 peptidoglycan transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0045087 innate immune response;GO:0140206 dipeptide import across plasma membrane;GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0015835 peptidoglycan transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BPX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTH6-1", "uniprot_id": [ { "id": "SCRT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTH6", "type": "external" } ], "mass": 32722.0, "length": 311, "protein_name": "Transcriptional repressor scratch 2", "gene_name": "Scrt2", "organism": "Mouse", "refseq_name": "transcriptional repressor scratch 2", "refseq_ac": [ { "id": "NP_001153882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153882", "type": "external" } ], "gene_names_uniprotkb": "Scrt2", "gene_names_refseq": "Scrt2", "protein_names_uniprotkb": "Transcriptional repressor scratch 2; Scratch homolog 2 zinc finger protein", "protein_names_refseq": "ortholog of human scratch homolog 2, zinc finger protein SCRT2; scratch homolog 2, zinc finger protein; transcriptional repressor scratch 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:545474)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16773660;23180754", "class_list": "", "function": "From perinatal to adult stages, Scratch2 expression progressively diminishes and virtually no expression can be detected in the adult brain., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; This study revealed that a modulatory role of Scrt2 protein in cortical neurogenesis and neuronal migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQU7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BTH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6I2-1", "uniprot_id": [ { "id": "SDHF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6I2", "type": "external" } ], "mass": 19431.0, "length": 164, "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "Sdhaf2", "organism": "Mouse", "refseq_name": "succinate dehydrogenase assembly factor 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_079609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079609", "type": "external" } ], "gene_names_uniprotkb": "Sdhaf2; PGL2; Pgl2; SDH5; SDHAF2; Sdh5", "gene_names_refseq": "0610038F07Rik; Sdhaf2", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2", "protein_names_refseq": "SDH assembly factor 2; succinate dehydrogenase assembly factor 2, mitochondrial precursor; succinate dehydrogenase assembly factor 2, mitochondrial; succinate dehydrogenase subunit 5, mitochondrial", "tax_id": 10090, "disease": "pheochromocytoma/paraganglioma syndrome 2 (Disease Ontology:DOID:0061217)", "pathway": " (mmu:66072); (R-MMU-9854311)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;34428180;38569044", "class_list": "", "function": "Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria., [RefSeq, PubMed]; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVE5;Q6PAS5;Q80ZJ9;Q8K2W8;Q9CYQ2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006470 protein dephosphorylation;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C6I2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C811-1", "uniprot_id": [ { "id": "S35E2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C811", "type": "external" } ], "mass": 44279.0, "length": 405, "protein_name": "Solute carrier family 35 member E2A", "gene_name": "Slc35e2a", "organism": "Mouse", "refseq_name": "solute carrier family 35 member E2A", "refseq_ac": [ { "id": "NP_796160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796160", "type": "external" } ], "gene_names_uniprotkb": "Slc35e2a; Slc35e2", "gene_names_refseq": "A530082C11Rik; Slc35e2a; Slc35e2", "protein_names_uniprotkb": "Solute carrier family 35 member E2A", "protein_names_refseq": "solute carrier family 35 member E2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:320541)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;27802388;30084848;34428180;35247439", "class_list": "", "function": "Putative transporter., [UniProtKB]; SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma. Erratum:[Life Sci. 2022 Jun 1;298:120493. doi: 10.1016/j.lfs.2022.120493. PMID: 35346501], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C811-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAK3-1", "uniprot_id": [ { "id": "SHFL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAK3", "type": "external" } ], "mass": 33015.0, "length": 290, "protein_name": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "gene_name": "Shfl", "organism": "Mouse", "refseq_name": "shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "refseq_ac": [ { "id": "NP_783618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783618", "type": "external" } ], "gene_names_uniprotkb": "Shfl; Ryden", "gene_names_refseq": "A230050P20Rik; RyDEN; Shfl", "protein_names_uniprotkb": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog; Repressor of yield of DENV protein homolog; RyDEN; SHFL", "protein_names_refseq": "UPF0515 protein C19orf66 homolog; repressor of yield of DENV protein homolog; shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:319278)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "33300544;34428180;34873063", "class_list": "", "function": "Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity., [UniProtKB, UniProtKB]; Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05BY8", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0034341 response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CAK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZV2-1", "uniprot_id": [ { "id": "SHSA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZV2", "type": "external" } ], "mass": 31466.0, "length": 295, "protein_name": "Protein shisa-2 homolog", "gene_name": "Shisa2", "organism": "Mouse", "refseq_name": "protein shisa-2 homolog precursor", "refseq_ac": [ { "id": "NP_663438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663438", "type": "external" } ], "gene_names_uniprotkb": "Shisa2; Shisa; Tmem46", "gene_names_refseq": "9430059P22Rik; MAd2; Shisa2; Tmem46; mShisa; shisa", "protein_names_uniprotkb": "Protein shisa-2 homolog; Shisa-like protein 2; Transmembrane protein 46; mShisa", "protein_names_refseq": "protein shisa-2 homolog precursor; protein shisa-2 homolog; shisa homolog 2; shisa-like protein 2; transmembrane protein 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:219134)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16773659;17481602;30084848;32848054", "class_list": "", "function": "Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling., [UniProtKB, PubMed, PubMed]; Shisa is antagonistic to Wnt and Fgf signalings, [RefSeq, PubMed]; Shisa is expressed throughout embryonic development, predominantly in the anterior visceral endoderm, headfolds, somites, forebrain, optic vesicle, and limb buds, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0NZZ5;Q8BN61", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030178 negative regulation of Wnt signaling pathway;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0F9-1", "uniprot_id": [ { "id": "S14L4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0F9", "type": "external" } ], "mass": 46053.0, "length": 403, "protein_name": "SEC14-like protein 4", "gene_name": "Sec14l4", "organism": "Mouse", "refseq_name": "SEC14-like protein 4", "refseq_ac": [ { "id": "NP_666125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666125", "type": "external" } ], "gene_names_uniprotkb": "Sec14l4", "gene_names_refseq": "SPF; Sec14l4; TAP", "protein_names_uniprotkb": "SEC14-like protein 4", "protein_names_refseq": "SEC14-like 2; SEC14-like 4; SEC14-like protein 4; alpha-tocopherol associated protein; squalene transfer protein; supernatant protein factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:103655)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17077281;19923370;25428506;34428180", "class_list": "", "function": "Deficiency of alpha-tocopherol in the circulation prevents cerebral malaria suggesting that this protein may be involved in early prevention of malaria., [RefSeq, PubMed]; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids., [UniProtKB]; The expression of SPF in response to food deprivation and fibrate administration is reported in wild-type and knockouk mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R0F9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1S9-1", "uniprot_id": [ { "id": "S38A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1S9", "type": "external" } ], "mass": 60464.0, "length": 547, "protein_name": "Sodium-coupled neutral amino acid transporter 4", "gene_name": "Slc38a4", "organism": "Mouse", "refseq_name": "sodium-coupled neutral amino acid transporter 4", "refseq_ac": [ { "id": "NP_081328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081328", "type": "external" } ], "gene_names_uniprotkb": "Slc38a4; Ata3; Nat3; Snat4", "gene_names_refseq": "1110012E16Rik; 1700012A18Rik; Ata3; SNAT4; Slc38a4; mATA3; mNAT3", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 4; Amino acid transporter A3; Na(+)-coupled neutral amino acid transporter 4; Solute carrier family 38 member 4; System A amino acid transporter 3", "protein_names_refseq": "Na(+)-coupled neutral amino acid transporter 4; amino acid transporter A3; sodium-coupled neutral amino acid transporter 4; system A amino acid transporter 3; system-N amino acid transporter 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69354); (R-MMU-352230)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11820791;12537539;21750661;23301202;23451088;30084848;31219806;31570606;31599954;34428180;36599932", "class_list": "", "function": "ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer., [RefSeq, PubMed]; Ata3 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray., [RefSeq, PubMed]; Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:12537539, PubMed:23301202, PubMed:23451088). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:12537539). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEZ9;Q3TJ89;Q3TPL5;Q8VIE7", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0061459 L-arginine transmembrane transporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031528 microvillus membrane;GO:0016020 membrane", "go_biological_process": "GO:1904557 L-alanine transmembrane transport;GO:0015804 neutral amino acid transport;GO:0003333 amino acid transmembrane transport;GO:1903826 L-arginine transmembrane transport;GO:1904273 L-alanine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R1S9-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCA0-1", "uniprot_id": [ { "id": "S22AJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCA0", "type": "external" } ], "mass": 60864.0, "length": 551, "protein_name": "Solute carrier family 22 member 19", "gene_name": "Slc22a19", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 19", "refseq_ac": [ { "id": "NP_659034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659034", "type": "external" } ], "gene_names_uniprotkb": "Slc22a19; Oat5; Slc22a9", "gene_names_refseq": "D630043A20Rik; OAT-5; Oat5; Slc22a19; Slc22a9", "protein_names_uniprotkb": "Solute carrier family 22 member 19; Organic anion transporter 5", "protein_names_refseq": "organic anion transporter 5; solute carrier family 22 (organic anion transporter), member 9; solute carrier family 22 (organic cation transporter), member 19; solute carrier family 22 member 19", "tax_id": 10090, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:207151)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15068970;16150593;17079864;20865662;34428180", "class_list": "", "function": "Highly expressed in kidney. Motive forces behind Oat5 function, which provide insight into its membrane localization, need to be further resolved., [RefSeq, PubMed]; MOAT5 has a role in excretion or reabsorption of steroid sulfates in the kidney, [RefSeq, PubMed]; MOATLP1 appears to be a novel candidate for an organic anion transporter isoform identified in the kidney., [RefSeq, PubMed]; Renal expression of Oat5 in rats (and mice) exhibits zonal and sex differences, [RefSeq, PubMed]; Sodium-independent organic anion transporter which shows high specificity for estrone sulfate, dehydroepiandrosterone sulfate, and the mycotoxin ochratoxin A (OTA) (PubMed:15068970, PubMed:16150593). Transport of OTA is strongly inhibited by estrone sulfate and probenecid, and to a lesser extent by 2,4-dichlorophenoxyacetic acid (2,4-D) and salicylate (PubMed:15068970). Transport of estrone sulfate is inhibited by various steroid sulfate conjugates including dehydroepiandrosterone sulfate, alpha-naphthyl sulfate, beta-estradiol sulfate, 4-methylumbelliferyl sulfate and p-nitrophenyl sulfate (but not minoxidil sulfate) (PubMed:16150593)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6A4K9", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0019534 toxin transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015636 short-chain fatty acid transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:0002238 response to molecule of fungal origin", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VCA0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHC3-1", "uniprot_id": [ { "id": "SELM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHC3", "type": "external" } ], "mass": 16378.0, "length": 145, "protein_name": "Selenoprotein M", "gene_name": "Selenom", "organism": "Mouse", "refseq_name": "selenoprotein M precursor", "refseq_ac": [ { "id": "NP_444497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444497", "type": "external" } ], "gene_names_uniprotkb": "Selenom", "gene_names_refseq": "1500040L08Rik; A230103K18; Selenom; Selm; Sepm", "protein_names_uniprotkb": "Selenoprotein M; SelM", "protein_names_refseq": "selenoprotein M precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:114679)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11839807;16258850;16319061;19769485;23880772;25428506;30648404;36635091;37190890", "class_list": "", "function": "May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation., [UniProtKB]; Mouse SelM had significantly suppressed on its transcriptional products in transgenic brains, [RefSeq, PubMed]; Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart., [RefSeq, PubMed]; SELENOM Knockout Induces Synaptic Deficits and Cognitive Dysfunction by Influencing Brain Glucose Metabolism., [RefSeq, PubMed]; SelM plays an important role in the regulation of body weight and energy metabolism., [RefSeq, PubMed]; Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity., [RefSeq, PubMed]; Sep15 and SelM have roles as thiol-disulfide oxidoreductases, [RefSeq, PubMed]; The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]., [RefSeq]; These results suggest that selenoprotein M may have an important role in protecting against oxidative damage in the brain and may potentially function in calcium regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVS9;Q3V374;Q8CBT7;Q8VCJ0", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035934 corticosterone secretion;GO:0060612 adipose tissue development;GO:0035264 multicellular organism growth;GO:0010269 response to selenium ion;GO:0042445 hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VHC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08641-1", "uniprot_id": [ { "id": "SH3Y1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08641", "type": "external" } ], "mass": 37028.0, "length": 340, "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "Sh3yl1", "organism": "Mouse", "refseq_name": "SH3 domain-containing YSC84-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001276409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276409", "type": "external" } ], "gene_names_uniprotkb": "Sh3yl1", "gene_names_refseq": "Ray; Sh3yl1; YSC84", "protein_names_uniprotkb": "SH3 domain-containing YSC84-like protein 1", "protein_names_refseq": "SH3 domain-containing YSC84-like protein 1 isoform 2; SH3 domain-containing YSC84-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:24057)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10771491;12615363;33086058;33223406;35820727", "class_list": "", "function": "LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1., [RefSeq, PubMed]; SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7V3;Q6PDR3", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0032587 ruffle membrane", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08641-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9K8-1", "uniprot_id": [ { "id": "E9Q9K8_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9K8", "type": "external" } ], "mass": 254323.0, "length": 2307, "protein_name": "A-kinase anchor protein 6", "gene_name": "Akap6", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 6", "refseq_ac": [ { "id": "NP_932779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932779", "type": "external" } ], "gene_names_uniprotkb": "Akap6", "gene_names_refseq": "Akap6; Akapalpha; Akapbeta; PRKA", "protein_names_uniprotkb": "A-kinase anchor protein 6; Protein kinase A-anchoring protein 6; mAKAP", "protein_names_refseq": "A kinase (PRKA) anchor protein 6; A-kinase anchor protein 6; A-kinase anchoring protein alpha; A-kinase anchoring protein beta; anchor protein 6", "tax_id": 10090, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (mmu:238161)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16337591;17114649;19574217;21750661;31325238", "class_list": "", "function": "AKAP6 interacts with PLN in HEK-293T and murine cardiomyocytes., [RefSeq, PubMed]; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes., [UniProtKB, UniProtKB]; The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy., [RefSeq, PubMed]; Two alternatively spliced forms of mAKAP are expressed: mAKAPalpha, the longer form, and mAKAPbeta. mAKAPalpha is preferentially expressed in brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9737, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0044325 transmembrane transporter binding;GO:0008179 adenylate cyclase binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1901897 regulation of relaxation of cardiac muscle;GO:0007194 negative regulation of adenylate cyclase activity;GO:0030307 positive regulation of cell growth;GO:0071320 cellular response to cAMP;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9Q9K8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYD1-1", "uniprot_id": [ { "id": "E9PYD1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYD1", "type": "external" } ], "mass": 37272.0, "length": 344, "protein_name": "Family with sequence similarity 98, member C", "gene_name": "Fam98c", "organism": "Mouse", "refseq_name": "protein FAM98C", "refseq_ac": [ { "id": "NP_001139495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139495", "type": "external" } ], "gene_names_uniprotkb": "Fam98c", "gene_names_refseq": "1110006G06Rik; B230110F21Rik; Fam98c", "protein_names_uniprotkb": "Family with sequence similarity 98, member C", "protein_names_refseq": "protein FAM98C", "tax_id": 10090, "disease": "", "pathway": " (mmu:73833)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PYD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924N4-1", "uniprot_id": [ { "id": "S12A6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924N4", "type": "external" } ], "mass": 127527.0, "length": 1150, "protein_name": "Solute carrier family 12 member 6", "gene_name": "Slc12a6", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 6 isoform 2", "refseq_ac": [ { "id": "NP_598410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598410", "type": "external" } ], "gene_names_uniprotkb": "Slc12a6; Kcc3", "gene_names_refseq": "9530023I19Rik; KCC3; Slc12a6; gaxp", "protein_names_uniprotkb": "Solute carrier family 12 member 6; Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3", "protein_names_refseq": "K-Cl cotransporter 3; electroneutral potassium-chloride cotransporter 3; solute carrier family 12 member 6 isoform 2", "tax_id": 10090, "disease": "agenesis of the corpus callosum with peripheral neuropathy (Disease Ontology:DOID:0090003); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); epilepsy (Disease Ontology:DOID:1826); motor peripheral neuropathy (Disease Ontology:DOID:2477)", "pathway": " (mmu:107723); (R-MMU-426117)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10347194;11246162;12368912;12386165;16048901;18566107;19144319;20173027;21750661;25428506;27485015;28011936;29187734;30084848;30779550;30899004;31439721;31649201;32506846;33596149;34428180;35274823;35822049;37507081;40021952", "class_list": "", "function": "Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes., [RefSeq, PubMed]; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity). May contribute to cell volume homeostasis in single cells (By similarity)., [UniProtKB, UniProtKB]; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10347194, PubMed:31649201). May contribute to cell volume homeostasis in single cells (Probable)., [UniProtKB, PubMed, PubMed]; Osmotic Response of Dorsal Root Ganglion Neurons Expressing Wild-Type and Mutant KCC3 Transporters., [RefSeq, PubMed]; SLC12A6 has a role in the development and maintenance of the nervous system Erratum:[Nat Genet 2002 Dec;32(4):681], [RefSeq, PubMed]; Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1) with the cotransporters KCC3, NKCC1, and NKCC2 but not KCC1 and KCC4, [RefSeq, PubMed]; Temporal manipulation of KCC3 expression in juvenile or adult mice suggests irreversible developmental deficit in hereditary motor sensory neuropathy with agenesis of the corpus callosum., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AGK1;Q924N3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0015079 potassium ion transmembrane transporter activity;GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0006811 monoatomic ion transport;GO:0071333 cellular response to glucose stimulus;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q924N4-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI23-1", "uniprot_id": [ { "id": "S12A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI23", "type": "external" } ], "mass": 77020.0, "length": 705, "protein_name": "Solute carrier family 12 member 8", "gene_name": "Slc12a8", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 8 isoform 2", "refseq_ac": [ { "id": "NP_001077371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077371", "type": "external" } ], "gene_names_uniprotkb": "Slc12a8; Ccc9", "gene_names_refseq": "CCC9; E330020C02Rik; Slc12a8", "protein_names_uniprotkb": "Solute carrier family 12 member 8; Cation-chloride cotransporter 9", "protein_names_refseq": "cation-chloride cotransporter 9; solute carrier family 12 member 8 isoform 2; solute carrier family 12 member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:171286)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNQ9;Q8K0M9", "ec_number_list": [], "go_molecular_function": "GO:0015379 potassium:chloride symporter activity;GO:0046873 metal ion transmembrane transporter activity;GO:0015377 chloride:monoatomic cation symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VI23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D174-1", "uniprot_id": [ { "id": "S18L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D174", "type": "external" } ], "mass": 8873.0, "length": 77, "protein_name": "SS18-like protein 2", "gene_name": "Ss18l2", "organism": "Mouse", "refseq_name": "SS18-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_081070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081070", "type": "external" } ], "gene_names_uniprotkb": "Ss18l2; Deb1", "gene_names_refseq": "1110020I04Rik; Deb1; Ss18l2", "protein_names_uniprotkb": "SS18-like protein 2", "protein_names_refseq": "Band 47B; SS18-like protein 2 isoform 1; SS18-like protein 2; differentially expressed in B16F10 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26901)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;30059200;30084848;30779550;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D174-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q0S6-1", "uniprot_id": [ { "id": "TENS1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q0S6", "type": "external" } ], "mass": 201383.0, "length": 1888, "protein_name": "Tensin-1", "gene_name": "Tns1", "organism": "Mouse", "refseq_name": "tensin-1 isoform a", "refseq_ac": [ { "id": "NP_082160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082160", "type": "external" } ], "gene_names_uniprotkb": "Tns1", "gene_names_refseq": "1110018I21Rik; 1200014E20Rik; E030018G17Rik; E030037J05Rik; Tns1; Tns", "protein_names_uniprotkb": "Tensin-1; 3.1.3.-", "protein_names_refseq": "tensin-1 isoform a", "tax_id": 10090, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:21961)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15592455;17242355;18630941;21750661;26427649;30059200;40885482", "class_list": "", "function": "May act as a protein phosphatase and/or a lipid phosphatase (By similarity). Involved in fibrillar adhesion formation (By similarity). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (By similarity). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity)., [UniProtKB, UniProtKB, PubMed]; May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studies demonstrate that TNS1 binds to DLC1 and fine-tunes its RhoGAP activity toward RhoA and that the TNS1-DLC1-RhoA signaling axis is critical in regulating cellular functions that lead to angiogenesis Erratum:[Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1383. doi: 10.1016/j.bbamcr.2018.05.016. PMID: 29866430], [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0004721 phosphoprotein phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0030055 cell-substrate junction", "go_biological_process": "GO:0007044 cell-substrate junction assembly;GO:0010761 fibroblast migration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9Q0S6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA37-1", "uniprot_id": [ { "id": "SAMD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA37", "type": "external" } ], "mass": 54713.0, "length": 478, "protein_name": "Sphingomyelin synthase-related protein 1", "gene_name": "Samd8", "organism": "Mouse", "refseq_name": "sphingomyelin synthase-related protein 1 isoform 1", "refseq_ac": [ { "id": "NP_080559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080559", "type": "external" } ], "gene_names_uniprotkb": "Samd8", "gene_names_refseq": "1110053F04Rik; 1700010P07Rik; PE-PLC; SMSr; Samd8", "protein_names_uniprotkb": "Sphingomyelin synthase-related protein 1; 2.7.8.-; 3.1.4.62; CPE synthase; Ceramide phosphoethanolamine synthase; PE-PLC; Phosphatidylethanolamine Phospholipase C; SAM domain-containing protein 8; SMSr; Sterile alpha motif domain-containing protein 8", "protein_names_refseq": "CPE synthase; GrailEXP prediction; SAM domain-containing protein 8; ceramide phosphoethanolamine synthase; phosphatidylethanolamine Phospholipase C; sphingomyelin synthase-related protein 1 isoform 1; sphingomyelin synthase-related protein 1; sterile alpha motif domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:67630); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14685263;21750661;25605874;37586586;40998032", "class_list": "", "function": "Has phospholipase C (PLC) activity (PubMed:40998032). Shows specificity for phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), hydrolyzing PE to produce phosphoethanolamine and diacylglycerol (1,2-diacyl-sn-glycerol, DAG) (PubMed:40998032). This reaction might act as a regulatory switch to activate serine palmitoyltransferase (SPT) and promote sphingolipid metabolism (PubMed:40998032). Can also function as a ceramide phosphoethanolamine (N-acylsphingoid 1-phosphoethanolamine, CPE) synthase when intracellular ceramide levels are elevated (PubMed:25605874). Binds the headgroup from PE, which is smaller and more hydrophilic than the phosphocholine headgroup transferred in the canonical sphingomyelin synthesis (SMS) reaction by SMS1 or SMS2, and transfers it on to the primary hydroxyl of a ceramide in the lumen of the endoplasmic reticulum. Plays a role as a ceramide sensor, helping to regulate ceramide homeostasis in the endoplasmic reticulum, which is critical for maintaining the integrity of the early secretory pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease. Erratum:[J Biol Chem. 2024 Apr;300(4):107204. doi: 10.1016/j.jbc.2024.107204. PMID: 38552502], [RefSeq, PubMed]; Study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.27", "type": "external" }, { "id": "2.7.8.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.-", "type": "external" }, { "id": "3.1.4.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.62", "type": "external" } ], "go_molecular_function": "GO:0002950 ceramide phosphoethanolamine synthase activity;GO:0033188 sphingomyelin synthase activity;GO:0047493 ceramide cholinephosphotransferase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:1905373 ceramide phosphoethanolamine biosynthetic process;GO:2000303 regulation of ceramide biosynthetic process;GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DA37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIL2-1", "uniprot_id": [ { "id": "RWDD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIL2", "type": "external" } ], "mass": 29890.0, "length": 267, "protein_name": "RWD domain-containing protein 3", "gene_name": "Rwdd3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rwdd3; Rsume; X2cr1", "gene_names_refseq": "", "protein_names_uniprotkb": "RWD domain-containing protein 3; RSUME; RWD domain-containing sumoylation enhancer", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:66568)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22009797", "class_list": "", "function": "Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXQ2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1902073 positive regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VIL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9E0-1", "uniprot_id": [ { "id": "S22AH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9E0", "type": "external" } ], "mass": 43195.0, "length": 401, "protein_name": "Solute carrier family 22 member 17", "gene_name": "Slc22a17", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 17 isoform 2", "refseq_ac": [ { "id": "NP_067526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067526", "type": "external" } ], "gene_names_uniprotkb": "Slc22a17; Boct", "gene_names_refseq": "1700094C23Rik; 24p3R; BOIT; Boct; Slc22a17", "protein_names_uniprotkb": "Solute carrier family 22 member 17; 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor", "protein_names_refseq": "24p3 receptor; brain-type organic cation transporter; lipocalin-2 receptor; organic cation transporter BOCT; solute carrier family 22 member 17 isoform 2; solute carrier family 22 member 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:59049); (R-MMU-917937)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16377569;21750661;22084236;30404645;38738428", "class_list": "", "function": "24p3R binds proteins filtered by the kidney with high affinity and may contribute to receptor-mediated endocy of proteins, [RefSeq, PubMed]; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Cloning of the lipocalin 24p3 receptor (24p3R). Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand., [RefSeq, PubMed]; Lcn2-R upregulation and Lcn2 downregulation via Wnt/beta-catenin may promote adaptive osmotolerant survival of IMCD cells Publication Status: Online-Only, [RefSeq, PubMed]; SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTM1", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0031090 organelle membrane;GO:0016020 membrane", "go_biological_process": "GO:0015891 siderophore transport;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1ASQ7-1", "uniprot_id": [ { "id": "B1ASQ7_MOUSE", "url": "https://www.uniprot.org/uniprot/B1ASQ7", "type": "external" } ], "mass": 94641.0, "length": 799, "protein_name": "Zinc finger protein 268", "gene_name": "Zfp268", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC433801", "refseq_ac": [ { "id": "NP_001311345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311345", "type": "external" } ], "gene_names_uniprotkb": "Zfp268", "gene_names_refseq": "Gm13212; Zfp268", "protein_names_uniprotkb": "Zinc finger protein 268", "protein_names_refseq": "novel KRAB box containing protein; uncharacterized protein LOC433801", "tax_id": 10090, "disease": "", "pathway": " (mmu:433801); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1ASQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTW5-1", "uniprot_id": [ { "id": "S22A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTW5", "type": "external" } ], "mass": 61053.0, "length": 551, "protein_name": "Solute carrier family 22 member 3", "gene_name": "Slc22a3", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 3", "refseq_ac": [ { "id": "NP_035525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035525", "type": "external" } ], "gene_names_uniprotkb": "Slc22a3; Oct3", "gene_names_refseq": "EMT; Oct3; Orct3; Slc22a3; Slca22a3", "protein_names_uniprotkb": "Solute carrier family 22 member 3; Organic cation transporter 3; mOCT3", "protein_names_refseq": "organic cation transporter 3; solute carrier family 22 member 3; solute carrier family 22, member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20519); (R-MMU-2161517); (R-MMU-549127)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10966924;11845212;18513366;19416912;21750661;25605945;27659446;30084848;37319217;9933568", "class_list": "", "function": "Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10966924, PubMed:18513366). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (By similarity). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, homovanillic acid, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:18513366, PubMed:19416912). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (By similarity). Also transports guanidine (PubMed:10966924). Mediates the transport of choline (By similarity). May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (PubMed:27659446)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation., [RefSeq, PubMed]; Slc22a3 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9R209", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0019534 toxin transmembrane transporter activity;GO:0008504 monoamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0012505 endomembrane system", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0015844 monoamine transport;GO:0015695 organic cation transport;GO:0032098 regulation of appetite;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WTW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6Z2-1", "uniprot_id": [ { "id": "K7N6Z2_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6Z2", "type": "external" } ], "mass": 99136.0, "length": 861, "protein_name": "Vomeronasal 2, receptor 97", "gene_name": "Vmn2r97", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vmn2r97", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal 2, receptor 97", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:627367)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6Z2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q067-1", "uniprot_id": [ { "id": "E9Q067_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q067", "type": "external" } ], "mass": 97972.0, "length": 851, "protein_name": "Vomeronasal 2, receptor 79", "gene_name": "Vmn2r79", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r79 precursor", "refseq_ac": [ { "id": "NP_001098660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098660", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r79", "gene_names_refseq": "EG621430; Vmn2r79", "protein_names_uniprotkb": "Vomeronasal 2, receptor 79", "protein_names_refseq": "vomeronasal receptor Vmn2r79 precursor; vomeronasal receptor Vmn2r79", "tax_id": 10090, "disease": "", "pathway": " (mmu:621430)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PXH8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q067-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKD3-1", "uniprot_id": [ { "id": "SCAM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKD3", "type": "external" } ], "mass": 26068.0, "length": 235, "protein_name": "Secretory carrier-associated membrane protein 5", "gene_name": "Scamp5", "organism": "Mouse", "refseq_name": "secretory carrier-associated membrane protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001288563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288563", "type": "external" } ], "gene_names_uniprotkb": "Scamp5", "gene_names_refseq": "Sc5; Scamp5", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 5; Secretory carrier membrane protein 5", "protein_names_refseq": "secretory carrier-associated membrane protein 5 isoform 1; secretory carrier-associated membrane protein 5", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:56807)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11050114;19240033;21750661;22299025;25428506;30779550;33300544;34678516", "class_list": "", "function": "Exposure to ER stress increases SCAMP5 in the striatum, which positively regulates mtHTT aggregation via the endocytosis pathway, [RefSeq, PubMed]; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity)., [UniProtKB]; This gene encodes a member of the Scamp (secretory carrier membrane protein) family. The encoded protein may be involved in neuronal vesicle trafficking. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0015031 protein transport;GO:0001819 positive regulation of cytokine production;GO:0006887 exocytosis;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JKD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WNM4-1", "uniprot_id": [ { "id": "A0A087WNM4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WNM4", "type": "external" } ], "mass": 26751.0, "length": 232, "protein_name": "Predicted gene, 21854", "gene_name": "Gm21854", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm21854", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 21854", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WNM4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D413-1", "uniprot_id": [ { "id": "SH2D6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D413", "type": "external" } ], "mass": 32016.0, "length": 297, "protein_name": "SH2 domain-containing protein 6", "gene_name": "Sh2d6", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sh2d6", "gene_names_refseq": "", "protein_names_uniprotkb": "SH2 domain-containing protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71130)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497J3", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D413-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERR7-1", "uniprot_id": [ { "id": "SEP15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERR7", "type": "external" } ], "mass": 17806.0, "length": 162, "protein_name": "Selenoprotein F", "gene_name": "Selenof", "organism": "Mouse", "refseq_name": "selenoprotein F precursor", "refseq_ac": [ { "id": "NP_444332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444332", "type": "external" } ], "gene_names_uniprotkb": "Selenof; Sep15", "gene_names_refseq": "9430015P09Rik; Selenof; Sep15", "protein_names_uniprotkb": "Selenoprotein F; 15 kDa selenoprotein", "protein_names_refseq": "15 kDa selenoprotein; selenoprotein 15; selenoprotein F precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:93684)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10945981;11278576;11898406;12600282;16129668;20388823;21750661;32995962;34428180;34638991;37721623", "class_list": "", "function": "Genetic and functional analysis of mammalian Sep15 selenoprotein., [RefSeq, PubMed]; LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p., [RefSeq, PubMed]; May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2., [UniProtKB, UniProtKB]; Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity. Publication Status: Online-Only, [RefSeq, PubMed]; Selenoprotein F knockout leads to glucose and lipid metabolism disorders in mice., [RefSeq, PubMed]; The cysteine-rich domain of Sep15 exclusively mediates protein-protein interactions with UDP-glucose:glycoprotein glucosyltransferase., [RefSeq, PubMed]; The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]., [RefSeq]; These data suggest tissue specificity in the cancer-protective effects of Sep15 downregulation, which are mediated, at least in part, by influencing the cell cycle., [RefSeq, PubMed]; Transfecting Sep15 gene did not influence the growth characteristics of BEL-7402 cell line and Sep15 may have redox function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXW1;Q544W8;Q8VE40", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0008379 thioredoxin peroxidase activity;GO:0008430 selenium binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0051084 'de novo' post-translational protein folding;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ERR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPB5-1", "uniprot_id": [ { "id": "SERHL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPB5", "type": "external" } ], "mass": 35311.0, "length": 311, "protein_name": "Serine hydrolase-like protein", "gene_name": "Serhl", "organism": "Mouse", "refseq_name": "serine hydrolase-like protein", "refseq_ac": [ { "id": "NP_075964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075964", "type": "external" } ], "gene_names_uniprotkb": "Serhl", "gene_names_refseq": "0610008B10Rik; 1110019M09Rik; Serhl", "protein_names_uniprotkb": "Serine hydrolase-like protein; 3.1.-.-; SHL", "protein_names_refseq": "SHL; serine hydrolase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68607)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11352564;21183079;21750661;26495903;34428180", "class_list": "", "function": "Probable serine hydrolase. May be related to cell muscle hypertrophy., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCZ8", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2Z4-1", "uniprot_id": [ { "id": "SENP8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2Z4", "type": "external" } ], "mass": 25057.0, "length": 221, "protein_name": "Sentrin-specific protease 8", "gene_name": "Senp8", "organism": "Mouse", "refseq_name": "sentrin-specific protease 8 isoform a", "refseq_ac": [ { "id": "NP_001165539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165539", "type": "external" } ], "gene_names_uniprotkb": "Senp8; Den1; Nedp1", "gene_names_refseq": "9130010J17Rik; Den1; Nedp1; Prsc2; Senp8", "protein_names_uniprotkb": "Sentrin-specific protease 8; 3.4.22.-; Deneddylase-1; NEDD8-specific protease 1; Sentrin/SUMO-specific protease SENP8", "protein_names_refseq": "NEDD8-specific protease 1; SUMO/sentrin specific peptidase 8; SUMO/sentrin specific protease 8; SUMO/sentrin specific protease family member 8; deneddylase-1; protease, cysteine, 2 (NEDD8 specific); sentrin-specific protease 8 isoform a; sentrin-specific protease 8; sentrin/SUMO-specific protease SENP8", "tax_id": 10090, "disease": "", "pathway": " (mmu:71599); (R-MMU-5689603); (R-MMU-8951664)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12759362;14673145;21750661", "class_list": "", "function": "Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543P0", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D2Z4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y63-1", "uniprot_id": [ { "id": "S13A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Y63", "type": "external" } ], "mass": 66143.0, "length": 600, "protein_name": "Na(+)/dicarboxylate cotransporter 3", "gene_name": "Slc13a3", "organism": "Mouse", "refseq_name": "Na(+)/dicarboxylate cotransporter 3", "refseq_ac": [ { "id": "NP_473396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473396", "type": "external" } ], "gene_names_uniprotkb": "Slc13a3; Nadc3; Sdct2", "gene_names_refseq": "NaC3; NaDC-3; NaDC3; SDCT2; Slc13a3", "protein_names_uniprotkb": "Na(+)/dicarboxylate cotransporter 3; Na(+)-coupled carboxylate transporter 3; NaC3; NaDC-3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3; mNaDC3", "protein_names_refseq": "Na(+)-coupled carboxylate transporter 3; Na(+)/dicarboxylate cotransporter 3; mNaDC3; sodium-dependent high-affinity dicarboxylate transporter 2; solute carrier family 13 member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:114644); (R-MMU-9955298)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11287335;17356845;21750661;38282243;39116875", "class_list": "", "function": "Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy., [RefSeq, PubMed]; Demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations, [RefSeq, PubMed]; High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:11287335). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:11287335). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (By similarity). Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response (PubMed:39116875)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0015137 citrate transmembrane transporter activity;GO:0015362 high-affinity sodium:dicarboxylate symporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0005343 organic acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0046942 carboxylic acid transport;GO:0015746 citrate transport;GO:0034775 glutathione transmembrane transport;GO:0015810 aspartate transmembrane transport;GO:0006835 dicarboxylic acid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91Y63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0E8-1", "uniprot_id": [ { "id": "S22A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0E8", "type": "external" } ], "mass": 62780.0, "length": 557, "protein_name": "Organic cation/carnitine transporter 2", "gene_name": "Slc22a5", "organism": "Mouse", "refseq_name": "organic cation/carnitine transporter 2 isoform 1", "refseq_ac": [ { "id": "NP_035526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035526", "type": "external" } ], "gene_names_uniprotkb": "Slc22a5; Octn2", "gene_names_refseq": "Lstpl; Octn2; Slc22a5; jvs", "protein_names_uniprotkb": "Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5", "protein_names_refseq": "high-affinity sodium-dependent carnitine cotransporter; juvenile visceral steatosis; organic cation/carnitine transporter 2 isoform 1; organic cation/carnitine transporter 2; solute carrier family 22 member 5", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); systemic primary carnitine deficiency disease (Disease Ontology:DOID:14365); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congestive heart failure (Disease Ontology:DOID:6000); inherited metabolic disorder (Disease Ontology:DOID:655); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:20520); (R-MMU-200425); (R-MMU-549127)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10454528;11010964;15523054;19144319;20722056;21183079;21750661;25428506;30084848;30899004;31845336;32070725;34428180;36293168;9837751;9916797", "class_list": "", "function": "Dystrophin deficiency likely disrupts Octn2 expression decreasing muscle carnitine uptake thus contributing to membranotoxic long-chain acyl-CoAs with sarcolemmal and organellar membrane oxidative injury, [RefSeq, PubMed]; PGC-1alpha and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse., [RefSeq, PubMed]; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:20722056). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 8836, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0009609 response to symbiotic bacterium;GO:0007626 locomotory behavior;GO:0034612 response to tumor necrosis factor;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9Z0E8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERH8-1", "uniprot_id": [ { "id": "S28A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERH8", "type": "external" } ], "mass": 78310.0, "length": 703, "protein_name": "Solute carrier family 28 member 3", "gene_name": "Slc28a3", "organism": "Mouse", "refseq_name": "solute carrier family 28 member 3", "refseq_ac": [ { "id": "NP_071712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071712", "type": "external" } ], "gene_names_uniprotkb": "Slc28a3; Cnt3", "gene_names_refseq": "Cnt3; Slc28a3", "protein_names_uniprotkb": "Solute carrier family 28 member 3; CNT 3; Concentrative Na(+)-nucleoside cotransporter 3; mCNT3", "protein_names_refseq": "CNT 3; concentrative Na(+)-nucleoside cotransporter 3; concentrative Na+-nucleoside cotransporter; mCNT3; solute carrier family 28 member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:114304); (R-MMU-83936); (R-MMU-9748787); (R-MMU-9755088)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11032837;21750661", "class_list": "", "function": "Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM72;Q8BWE2;Q91VD7", "ec_number_list": [], "go_molecular_function": "GO:0015213 uridine transmembrane transporter activity;GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity;GO:0015390 purine-specific nucleoside:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport;GO:0001895 retina homeostasis;GO:0015864 pyrimidine nucleoside transport;GO:1901642 nucleoside transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ERH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VE0-1", "uniprot_id": [ { "id": "S27A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VE0", "type": "external" } ], "mass": 72319.0, "length": 643, "protein_name": "Long-chain fatty acid transport protein 4", "gene_name": "Slc27a4", "organism": "Mouse", "refseq_name": "long-chain fatty acid transport protein 4", "refseq_ac": [ { "id": "NP_036119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036119", "type": "external" } ], "gene_names_uniprotkb": "Slc27a4; Acsvl4; Fatp4", "gene_names_refseq": "ACSVL4; FATP4; Slc27a4", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 4; 6.2.1.-; 6.2.1.15; 6.2.1.3; ACSVL4; Arachidonate--CoA ligase; FATP-4; Fatty acid transport protein 4; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4", "protein_names_refseq": "arachidonate--CoA ligase; long-chain fatty acid transport protein 4; long-chain-fatty-acid--CoA ligase; very long-chain acyl-CoA synthetase 4", "tax_id": 10090, "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:26569); (R-MMU-804914)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10518211;11404000;12697906;12821645;14512415;15653672;15699031;16452087;20448275;23407971;31219806;34203471;35820727;38811164;9671728", "class_list": "", "function": "Ablation of Fatty Acid Transport Protein-4 Enhances Cone Survival, M-cone Vision, and Synthesis of Cone-Tropic 9-cis-Retinal in rd12 Mouse Model of Leber Congenital Amaurosis. Publication Status: Online-Only, [RefSeq, PubMed]; Fatp4-null mice displayed features of a neonatally lethal restrictive dermopathy. Lipid analysis demonstrated a disturbed fatty acid composition of epidermal ceramides., [RefSeq, PubMed]; Identification of critical role in skin and hair development, [RefSeq, PubMed]; Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:20448275). Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (By similarity). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (PubMed:11404000, PubMed:12821645, PubMed:15653672, PubMed:15699031). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (PubMed:23407971)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88562;Q3TD48", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031526 brush border membrane;GO:0005902 microvillus", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1990379 lipid transport across blood-brain barrier;GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q91VE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X56-1", "uniprot_id": [ { "id": "S1PR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X56", "type": "external" } ], "mass": 42331.0, "length": 400, "protein_name": "Sphingosine 1-phosphate receptor 5", "gene_name": "S1pr5", "organism": "Mouse", "refseq_name": "sphingosine 1-phosphate receptor 5", "refseq_ac": [ { "id": "NP_444420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444420", "type": "external" } ], "gene_names_uniprotkb": "S1pr5; Edg8; Lpb4", "gene_names_refseq": "Edg8; S1P5; S1pr5; lpB4", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 5; Endothelial differentiation G protein-coupled receptor 8; Lysophospholipid receptor B4; S1P receptor 5; S1P receptor Edg-8; S1P5; Sphingosine 1-phosphate receptor Edg-8", "protein_names_refseq": "S1P receptor 5; S1P receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; lysophospholipid receptor B4; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor Edg-8; sphingosine-1-phosphate receptor LPB4", "tax_id": 10090, "disease": "", "pathway": " (mmu:94226); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11705398;11967257;15703400;21183079;25605945;34428180", "class_list": "", "function": "Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell., [UniProtKB, PubMed]; The immune modulator FTY720 targets sphingosine 1-phosphate receptors., [RefSeq, PubMed]; The molecular identity, functional properties, and expression profile of the S1P5 (Edg-8) receptor have been characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99MN8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91X56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JZ0-1", "uniprot_id": [ { "id": "SDCB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JZ0", "type": "external" } ], "mass": 31565.0, "length": 292, "protein_name": "Syntenin-2", "gene_name": "Sdcbp2", "organism": "Mouse", "refseq_name": "syntenin-2", "refseq_ac": [ { "id": "NP_663510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663510", "type": "external" } ], "gene_names_uniprotkb": "Sdcbp2", "gene_names_refseq": "Sdcbp2", "protein_names_uniprotkb": "Syntenin-2; Syndecan-binding protein 2", "protein_names_refseq": "syndecan-binding protein 2; syntenin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:228765)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "glycogene", "function": "Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UN51", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99JZ0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N99-1", "uniprot_id": [ { "id": "S5A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N99", "type": "external" } ], "mass": 28619.0, "length": 254, "protein_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2", "gene_name": "Srd5a2", "organism": "Mouse", "refseq_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2", "refseq_ac": [ { "id": "NP_444418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444418", "type": "external" } ], "gene_names_uniprotkb": "Srd5a2; 5art2", "gene_names_refseq": "5ART2; S5AR 2; Srd5a2", "protein_names_uniprotkb": "3-oxo-5-alpha-steroid 4-dehydrogenase 2; 1.3.1.22; 5 alpha-SR2; S5AR 2; SR type 2; Steroid 5-alpha-reductase 2", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; SR type 2; steroid 5 alpha reductase type2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypospadias (Disease Ontology:DOID:10892); hyperprolactinemia (Disease Ontology:DOID:12700); breast carcinoma (Disease Ontology:DOID:3459); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:94224); (R-MMU-193048)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11884637;15860270;19500568;38606616", "class_list": "", "function": "Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms. Converts testosterone into 5-alpha-dihydrotestosterone (DHT), the most active androgen in the prostate, as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development. Besides testosterone, it can also act on other steroids, including progesterone, producing metabolites with diverse roles. Hence, it plays a central role in sexual differentiation and androgen physiology., [UniProtKB, UniProtKB]; Enhanced prostatic Esr1[+] luminal epithelial cells in the absence of SRD5A2., [RefSeq, PubMed]; Molecular cloning & transcriptional activation of the gene, [RefSeq, PubMed]; Observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes, [RefSeq, PubMed]; The induction of Srd5a2 through SREBP-2 provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTZ9", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0033218 amide binding;GO:0047045 testosterone dehydrogenase (NADP+) activity;GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane;GO:0070852 cell body fiber", "go_biological_process": "GO:0030540 female genitalia development;GO:0030154 cell differentiation;GO:0021766 hippocampus development;GO:0031667 response to nutrient levels;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99N99-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PL7-1", "uniprot_id": [ { "id": "SCD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PL7", "type": "external" } ], "mass": 41432.0, "length": 359, "protein_name": "Acyl-CoA desaturase 3", "gene_name": "Scd3", "organism": "Mouse", "refseq_name": "acyl-CoA desaturase 3", "refseq_ac": [ { "id": "NP_077770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077770", "type": "external" } ], "gene_names_uniprotkb": "Scd3", "gene_names_refseq": "4930513N16Rik; Scd3", "protein_names_uniprotkb": "Acyl-CoA desaturase 3; 1.14.19.-; Delta(9)-desaturase 3; Delta-9 desaturase 3; Fatty acid desaturase 3; Palmitoyl-CoA desaturase; Stearoyl-CoA desaturase 3", "protein_names_refseq": "acyl-CoA desaturase 3; delta(9)-desaturase 3; fatty acid desaturase 3; palmitoyl-CoA desaturase; stearoyl-CoA desaturase 3", "tax_id": 10090, "disease": "restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (mmu:30049)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11161812;16118274;16443825;26098370;34428180", "class_list": "glycogene", "function": "Results show that mouse stearoyl-coenzyme A desaturase (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse SCD3 uses C16:0 but not C18:0., [RefSeq, PubMed]; Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA (PubMed:16443825, PubMed:26098370). Has a strong preference for saturated fatty acids with chain lengths of 14 or 16 carbon atoms (C14:0 and C16:0), and has only very low activity with stearatate (C18:0) (PubMed:16443825, PubMed:26098370). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWK5;Q9D550", "ec_number_list": [ { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "1.14.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016491 oxidoreductase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006636 unsaturated fatty acid biosynthetic process;GO:1903966 monounsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99PL7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PL8-1", "uniprot_id": [ { "id": "S19A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PL8", "type": "external" } ], "mass": 55073.0, "length": 488, "protein_name": "Thiamine transporter 2", "gene_name": "Slc19a3", "organism": "Mouse", "refseq_name": "thiamine transporter 2 precursor", "refseq_ac": [ { "id": "NP_085033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085033", "type": "external" } ], "gene_names_uniprotkb": "Slc19a3", "gene_names_refseq": "A230084E24Rik; Slc19a3; ThTr2", "protein_names_uniprotkb": "Thiamine transporter 2; Solute carrier family 19 member 3; ThTr-2; ThTr2", "protein_names_refseq": "solute carrier family 19 (sodium/hydrogen exchanger), member 3; thTr-2; thiamine transporter 2 precursor; thiamine transporter 2", "tax_id": 10090, "disease": "biotin-responsive basal ganglia disease (Disease Ontology:DOID:0050659); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:80721); (R-MMU-196819)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11136550;14770311;16206251;19879271;22194418;28665968;35512554;35724964", "class_list": "", "function": "Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine., [RefSeq, PubMed]; Both mTHTR-1 and mTHTR-2 are involved in carrier-mediated thiamin uptake by pancreatic acinar cells., [RefSeq, PubMed]; High-affinity transporter for the intake of thiamine (PubMed:22194418, PubMed:35512554, PubMed:35724964). Unlike the human ortholog, lacks H(+)-dependent pyridoxine transport activity due to an absence of seven critical amino-acids required for pyridoxine transport (PubMed:35512554, PubMed:35724964)., [UniProtKB, PubMed, PubMed, PubMed]; Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3., [RefSeq, PubMed]; Intestinal and renal thiamin uptake are developmentally regulated during early stages of life, mediated through mTHTR-1 and mTHTR-2, and suggest the possible involvement of transcriptional regulatory mechanism(s) in this regulation., [RefSeq, PubMed]; Showed that acute neurodegeneration caused by thiamine deficiency is preventable in most parts, and prompt high-dose thiamine administration is critical for the treatment of THMD2. However, reduction of thiamine should be performed carefully to prevent recurrence after recovery of the disease Publication Status: Online-Only, [RefSeq, PubMed]; THTR-2 is required for normal uptake of thiamin in the intestine and can fulfill normal levels of uptake in conditions associated with THTR-1 dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q32MF5", "ec_number_list": [], "go_molecular_function": "GO:0015234 thiamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0015888 thiamine transport;GO:0071934 thiamine transmembrane transport;GO:0031923 pyridoxine transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99PL8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZN4-1", "uniprot_id": [ { "id": "SHSA9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZN4", "type": "external" } ], "mass": 46842.0, "length": 424, "protein_name": "Protein shisa-9", "gene_name": "Shisa9", "organism": "Mouse", "refseq_name": "protein shisa-9 isoform 1 precursor", "refseq_ac": [ { "id": "NP_082553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082553", "type": "external" } ], "gene_names_uniprotkb": "Shisa9", "gene_names_refseq": "2700045P11Rik; Ckamp44; Shisa9", "protein_names_uniprotkb": "Protein shisa-9; CKAMP44; Cystine-knot AMPAR modulating protein of 44 kDa", "protein_names_refseq": "cystine-knot AMPAR modulating protein of 44 kDa; protein shisa-9 isoform 1 precursor; protein shisa-9; shisa homolog 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:72555)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20185686;21750661;24498314;25066086;26645823;29343769;30084848;35770953;35820727;37081201", "class_list": "", "function": "CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus., [RefSeq, PubMed]; CKAMP44 identified as a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines; findings show that CKAMP44 modulates short-term plasticity at specific excitatory synapses, [RefSeq, PubMed]; Ckamp44 expression is strongest in dentate gyrus granule cells and less abundant in the rest of the brain, [RefSeq, PubMed]; Coexpression of both auxiliary subunits,CKAMP44 and TARP gamma-8 is necessary for the efficient targeting of AMPARs to the cell surface of dentate gyrus granule cells, [RefSeq, PubMed]; Data indicate the importance of CKAMP44 for modulating synaptic short-term depression and visual input integration. Publication Status: Online-Only, [RefSeq, PubMed]; Data show interaction partners of AMPA receptor auxiliary subunit Shisa9, and that the C-terminal interactions of Shisa9 through its PDZ domain interaction motif are important for AMPA receptor synaptic and network functions. Publication Status: Online-Only, [RefSeq, PubMed]; Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice., [RefSeq, PubMed]; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D4NZG2;D4NZG3", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CZN4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1M0-1", "uniprot_id": [ { "id": "SEC13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1M0", "type": "external" } ], "mass": 35566.0, "length": 322, "protein_name": "Protein SEC13 homolog", "gene_name": "Sec13", "organism": "Mouse", "refseq_name": "protein SEC13 homolog", "refseq_ac": [ { "id": "NP_077168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077168", "type": "external" } ], "gene_names_uniprotkb": "Sec13; Sec13l1", "gene_names_refseq": "1110003H02Rik; Sec13l1; Sec13r; Sec13", "protein_names_uniprotkb": "Protein SEC13 homolog; GATOR2 complex protein SEC13; SEC13-like protein 1; SEC13-related protein", "protein_names_refseq": "GATOR complex protein SEC13; GATOR2 complex protein SEC13; SEC13 related; SEC13-like 1; SEC13-like protein 1; SEC13-related protein; protein SEC13 homolog", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:110379); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-204005); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9639288); (R-MMU-9648025); (R-MMU-983170)", "pathway_count": 29, "publication_count": 5, "publication_id_list": "26631972;27354378;29187734;31219806;39159700", "class_list": "", "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex., [UniProtKB, UniProtKB]; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (PubMed:27354378)., [UniProtKB, UniProtKB, PubMed]; Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI., [RefSeq, PubMed]; Sec13 regulates specific expression of immune factors with key functions in inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M12;Q9D712", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0090110 COPII-coated vesicle cargo loading;GO:0006913 nucleocytoplasmic transport;GO:0072659 protein localization to plasma membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1M0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPK6-1", "uniprot_id": [ { "id": "SIL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPK6", "type": "external" } ], "mass": 52430.0, "length": 465, "protein_name": "Nucleotide exchange factor SIL1", "gene_name": "Sil1", "organism": "Mouse", "refseq_name": "nucleotide exchange factor SIL1 precursor", "refseq_ac": [ { "id": "NP_109674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109674", "type": "external" } ], "gene_names_uniprotkb": "Sil1", "gene_names_refseq": "1810057E01Rik; Sil1; wz", "protein_names_uniprotkb": "Nucleotide exchange factor SIL1", "protein_names_refseq": "endoplasmic reticulum chaperone SIL1 homolog; nucleotide exchange factor SIL1 precursor; nucleotide exchange factor SIL1", "tax_id": 10090, "disease": "Marinesco-Sjogren syndrome (Disease Ontology:DOID:0080195); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (mmu:81500)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11101517;16116427;16282977;16282978;21750661;26740625;28528544;29718201;30084848;30468864;30779550;30899004;31531014;34428180;37828378;39950214", "class_list": "", "function": "Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. The data expand the spectrum of tissues affected by SIL1-loss and suggest that impaired neuromuscular transmission might be part of Marinesco-Sjogren Syndrome pathophysiology., [RefSeq, PubMed]; SIL1 is required for the development of the central nervous system which is associated with its role in Reelin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The protein but not the mRNA level of ORP150, a nucleotide exchange factor which can substitute for SIL1, was increased in the cerebellum of GSK2606414-treated woozy mice, suggesting that translational recovery promoted the synthesis of this alternative BiP co-factor, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91V34", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9EPK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIP7-1", "uniprot_id": [ { "id": "S15A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIP7", "type": "external" } ], "mass": 78560.0, "length": 709, "protein_name": "Solute carrier family 15 member 1", "gene_name": "Slc15a1", "organism": "Mouse", "refseq_name": "solute carrier family 15 member 1", "refseq_ac": [ { "id": "NP_444309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444309", "type": "external" } ], "gene_names_uniprotkb": "Slc15a1; Pept1", "gene_names_refseq": "D630032F02; PECT1; PEPT1; Slc15a1", "protein_names_uniprotkb": "Solute carrier family 15 member 1; Intestinal H(+)/peptide cotransporter; Oligopeptide transporter, small intestine isoform; Peptide transporter 1; Proton-coupled dipeptide cotransporter", "protein_names_refseq": "intestinal H(+)/peptide cotransporter; intestinal peptide transporter PEPT1; peptide transporter 1; proton-coupled dipeptide cotransporter; solute carrier family 15 member 1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56643); (R-MMU-427975)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11004485;16202478;16328452;17932227;18322073;19349973;26320580;26585416;28336547;31219806;32694535;33759563;34428180", "class_list": "", "function": "Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity) (PubMed:11004485). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Glycosylation of PEPT1 confers resistance against proteolytic cleavage by proteinase K, whereas a remarkable intrinsic stability against trypsin, even in the absence of N-linked glycans, was detected., [RefSeq, PubMed]; Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations. Publication Status: Online-Only, [RefSeq, PubMed]; In conclusion, the association of PepT1 with lipid rafts differently modulates its transport activity in polarized and nonpolarized cells., [RefSeq, PubMed]; PDZK1 regulates two intestinal transporters, Slc15a1 and Slc22a5, as an adaptor protein for these transporters and affects oral absorption of their substrates., [RefSeq, PubMed]; PepT1-knockout mice harbor a protective metabolome beneficial for intestinal wound healing., [RefSeq, PubMed]; Pept1 mRNA was not only highly expressed in small intestine, but also detectable in gonads and large intestine of mice, [RefSeq, PubMed]; Treatment with interleukin-1beta increased PepT1 mRNA expression in mouse proximal and distal colon and decreased PepT1 mRNA expression in jejunum and ileum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 6, "mined_n_glycosites": 6, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QMX3", "ec_number_list": [], "go_molecular_function": "GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0015333 peptide:proton symporter activity;GO:0016248 channel inhibitor activity;GO:0042937 tripeptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006857 oligopeptide transport;GO:0140206 dipeptide import across plasma membrane;GO:0051956 negative regulation of amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JIP7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0U9-1", "uniprot_id": [ { "id": "S1PR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0U9", "type": "external" } ], "mass": 42270.0, "length": 378, "protein_name": "Sphingosine 1-phosphate receptor 3", "gene_name": "S1pr3", "organism": "Mouse", "refseq_name": "sphingosine 1-phosphate receptor 3", "refseq_ac": [ { "id": "NP_034231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034231", "type": "external" } ], "gene_names_uniprotkb": "S1pr3; Edg3; Lpb3", "gene_names_refseq": "Edg3; Lpb3; S1p3; S1pr3", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 3; Endothelial differentiation G protein-coupled receptor 3; Lysophospholipid receptor B3; S1P receptor 3; S1P receptor Edg-3; S1P3; Sphingosine 1-phosphate receptor Edg-3", "protein_names_refseq": "S1P receptor Edg-3; S1p receptor 3; endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; lysophospholipid receptor B3; sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:13610); (R-MMU-418594); (R-MMU-419408); (R-MMU-9009391)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12006579;12401212;14966566;38852936;9931453", "class_list": "", "function": "Data identify HDL as a carrier of bioactive lysophospholipids that regulate vascular tone via S1P3-mediated nitric oxide release., [RefSeq, PubMed]; Mice null for both EDG-5 and EDG-3 show marked perinatal lethality and cellular signaling defect, [RefSeq, PubMed]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues., [UniProtKB]; S1p(1-3) influence angiogenesis in the developing brain, [RefSeq, PubMed]; SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway., [RefSeq, PubMed]; This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP20", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0032651 regulation of interleukin-1 beta production;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z0U9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1W5-1", "uniprot_id": [ { "id": "SERP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1W5", "type": "external" } ], "mass": 7374.0, "length": 66, "protein_name": "Stress-associated endoplasmic reticulum protein 1", "gene_name": "Serp1", "organism": "Mouse", "refseq_name": "stress-associated endoplasmic reticulum protein 1", "refseq_ac": [ { "id": "NP_109610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109610", "type": "external" } ], "gene_names_uniprotkb": "Serp1; D3Ucla1; Ramp4", "gene_names_refseq": "D3Ucla1; Ramp4; Serp1", "protein_names_uniprotkb": "Stress-associated endoplasmic reticulum protein 1; Ribosome-attached membrane protein 4", "protein_names_refseq": "ribosome associated membrane protein 4; ribosome-attached membrane protein 4; stress-associated endoplasmic reticulum protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:28146); (R-MMU-9609523)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16705175;25428506;28597972;30084848;30497776;35419615", "class_list": "", "function": "Findings identify a group of proteins that interact with GLP-1R and show that one specific interacting protein, SERP1, has an important role in facilitating the glycosylation of GLP-1R and rescuing its activities after ER stress induced by tunicamycin., [RefSeq, PubMed]; Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins., [UniProtKB, UniProtKB]; SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3beta/betacatenin/TCF/LEF signaling pathway., [RefSeq, PubMed]; SERP1-/- mice, made by targeted gene disruption, demonstrated growth retardation, increased mortality, and impaired glucose tolerance., [RefSeq, PubMed]; This study suggests SERP1 as a potential regulator invovled in the pathophysiology of myocardial ischemia/reperfusion injury(MI/R injury)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMC9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0001501 skeletal system development;GO:0006006 glucose metabolic process;GO:0009791 post-embryonic development;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z1W5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5W3-1", "uniprot_id": [ { "id": "A0A075B5W3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5W3", "type": "external" } ], "mass": 12792.0, "length": 117, "protein_name": "Immunoglobulin heavy variable 1-53", "gene_name": "Ighv1-53", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-53", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-53", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5W3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5X4-1", "uniprot_id": [ { "id": "A0A075B5X4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5X4", "type": "external" } ], "mass": 13082.0, "length": 119, "protein_name": "Immunoglobulin heavy variable V8-11", "gene_name": "Ighv8-11", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv8-11", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V8-11", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); 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"0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PXN3-1", "uniprot_id": [ { "id": "E9PXN3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PXN3", "type": "external" } ], "mass": 35280.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or52b4", "organism": "Mouse", "refseq_name": "olfactory receptor 547", "refseq_ac": [ { "id": "NP_667290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667290", "type": "external" } ], "gene_names_uniprotkb": "Or52b4; Olfr547; Olfr548-ps1", "gene_names_refseq": "MOR31-4; Olfr547; Or52b4", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-5256044-5256988; olfactory receptor 547; olfactory receptor MOR31-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:259083)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19166503;21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Olfr69", "gene_names_refseq": "3'[b]3; 3'beta3; MOR22-2; Olfr69; Or52a5b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6494485-6493535; olfactory receptor 69; olfactory receptor MOR22-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18370)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"Zfp811", "gene_names_refseq": "Zfp811", "protein_names_uniprotkb": "Zinc finger protein 811", "protein_names_refseq": "zinc finger protein 811 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:240063); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, 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transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0J9YU71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z393-1", "uniprot_id": [ { "id": "D3Z393_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z393", "type": "external" } ], "mass": 24777.0, "length": 217, "protein_name": "Makorin, ring finger protein 2, opposite strand", "gene_name": "Mkrn2os", "organism": "Mouse", "refseq_name": "MKRN2 opposite strand protein", "refseq_ac": [ { "id": "NP_001094901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094901", "type": "external" } ], "gene_names_uniprotkb": "Mkrn2os", "gene_names_refseq": "2510049J12Rik; Mkrn2os", "protein_names_uniprotkb": "Makorin, ring finger protein 2, opposite strand", "protein_names_refseq": "MKRN2 opposite strand protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70291)", "pathway_count": 1, 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0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z393-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L3P4-1", "uniprot_id": [ { "id": "SL9A6_MOUSE", "url": "https://www.uniprot.org/uniprot/A1L3P4", "type": "external" } ], "mass": 77953.0, "length": 702, "protein_name": "Sodium/hydrogen exchanger 6", "gene_name": "Slc9a6", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_766368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766368", "type": "external" } ], "gene_names_uniprotkb": "Slc9a6; 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[RefSeq, PubMed]; Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:17005858, PubMed:21413028, PubMed:24035762, PubMed:34526390). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (PubMed:21413028, PubMed:34526390). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (By similarity). Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (PubMed:17005858, PubMed:21413028)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; GGA1 interacts with the endosomal Na+/H+ exchanger NHE6 governing localization to the endosome compartment., [RefSeq, PubMed]; NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Publication Status: Online-Only, [RefSeq, PubMed]; NHE6 is expressed in the inner ear, [RefSeq, PubMed]; This review describes Nhe6 knockout mice, which partially mimic phenotypical features of patients suffering from mental disorders including motor hyperactivity and a lowered threshold for pharmacologically induced seizures. 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0031941 filamentous actin", "go_biological_process": "GO:0007015 actin filament organization;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AF33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BFR3-1", "uniprot_id": [ { "id": "A2BFR3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BFR3", "type": "external" } ], "mass": 12207.0, "length": 109, "protein_name": "Histone H2A", "gene_name": "H2al1j", "organism": "Mouse", "refseq_name": "histone cluster 2 family member", "refseq_ac": [ { "id": "NP_001108001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108001", "type": "external" } ], "gene_names_uniprotkb": "H2al1j; Gm4906", "gene_names_refseq": "EG236663; Gm4906; H2al1j", "protein_names_uniprotkb": "Histone H2A", "protein_names_refseq": "histone cluster 2 family member", "tax_id": 10090, "disease": "", "pathway": " (mmu:236663)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0031507 heterochromatin formation;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BFR3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1B0X0-1", "uniprot_id": [ { "id": "B1B0X0_MOUSE", "url": "https://www.uniprot.org/uniprot/B1B0X0", "type": "external" } ], "mass": 52865.0, "length": 449, "protein_name": "Predicted gene 15107", "gene_name": "Gm15107", "organism": "Mouse", "refseq_name": "ovary testis transcribed", "refseq_ac": [ { "id": "NP_001075117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075117", "type": "external" } ], "gene_names_uniprotkb": "Gm15107", "gene_names_refseq": "Gm15107; Ott-like", "protein_names_uniprotkb": "Predicted gene 15107", "protein_names_refseq": "ovary testis transcribed", "tax_id": 10090, "disease": "", "pathway": " (mmu:434864)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1B0X0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YYI9-1", "uniprot_id": [ { "id": "D3YYI9_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YYI9", "type": "external" } ], "mass": 31500.0, "length": 267, "protein_name": "Predicted gene 7347", "gene_name": "Gm7347", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC664804 isoform 1", "refseq_ac": [ { "id": "NP_001365564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365564", "type": "external" } ], "gene_names_uniprotkb": "Gm7347", "gene_names_refseq": "EG664804; Gm7347", "protein_names_uniprotkb": "Predicted gene 7347", "protein_names_refseq": "uncharacterized protein LOC664804 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:664804)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YYI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z450-1", "uniprot_id": [ { "id": "D3Z450_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z450", "type": "external" } ], "mass": 45737.0, "length": 408, "protein_name": "Serine (or cysteine) peptidase inhibitor, clade A, member 3I", "gene_name": "Serpina3i", "organism": "Mouse", "refseq_name": "serine (or cysteine) peptidase inhibitor, clade A, member 3I", "refseq_ac": [ { "id": "NP_001186869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186869", "type": "external" } ], "gene_names_uniprotkb": "Serpina3i", "gene_names_refseq": "2B2; EG628900; Gm6930; Serpina3i", "protein_names_uniprotkb": "Serine (or cysteine) peptidase inhibitor, clade A, member 3I", "protein_names_refseq": "alpha-1 antiproteinase; antitrypsin; serine (or cysteine) peptidase inhibitor, clade A, member 3I; serine (or cysteine) proteinase inhibitor, clade A, member 3I", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:628900)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z450-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q468-1", "uniprot_id": [ { "id": "E9Q468_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q468", "type": "external" } ], "mass": 48252.0, "length": 432, "protein_name": "Neuropeptide FF receptor 1", "gene_name": "Npffr1", "organism": "Mouse", "refseq_name": "neuropeptide FF receptor 1", "refseq_ac": [ { "id": "NP_001170982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170982", "type": "external" } ], "gene_names_uniprotkb": "Npffr1", "gene_names_refseq": "Gm236; Gpr147; NPFF1R; NPFF1; Npffr1; OT7T022", "protein_names_uniprotkb": "Neuropeptide FF receptor 1; G-protein coupled receptor 147; RFamide-related peptide receptor OT7T022", "protein_names_refseq": "G protein-coupled receptor 147; G-protein coupled receptor NPFF1R; RFamide-related peptide receptor; neuropeptide FF receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:237362); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14696013;20554321;21750661;22355072;30075164;30081043;38072091", "class_list": "", "function": "Central NPFF1 and NPFF2 receptors control in an opposite manner the body temperature in mice., [RefSeq, PubMed]; Our data support a discernible orexigenic role of NPFF1R signaling selectively in males, which might modulate the effects of leptin and ghrelin on food intake, [RefSeq, PubMed]; RFRP-3 activated PI3K/AKT and ERK1/2 signaling cascades and promotes pancreatic alpha cell survival, likely via GPR147., [RefSeq, PubMed]; RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH., [RefSeq, PubMed]; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB]; Rfamide-related peptide-3(RFRP-3) receptor gene is expressed in mouse ovarian granulosa cells: Potential role of RFRP-3 in steroidogenesis and apoptosis., [RefSeq, PubMed]; The constant presence of NPFF1 receptors in the septum, the nucleus of the tractus solitarius, and the hypothalamus suggest its participation in neuroendocrine functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q468-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6YJZ8-1", "uniprot_id": [ { "id": "F6YJZ8_MOUSE", "url": "https://www.uniprot.org/uniprot/F6YJZ8", "type": "external" } ], "mass": 23614.0, "length": 199, "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1H", "gene_name": "Speer1h", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC623898", "refseq_ac": [ { "id": "NP_001033008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033008", "type": "external" } ], "gene_names_uniprotkb": "Speer1h; Gm6460", "gene_names_refseq": "EG623898; Gm6460; Speer1h", "protein_names_uniprotkb": "Spermatogenesis associated glutamate (E)-rich protein 1H", "protein_names_refseq": "uncharacterized protein LOC623898", "tax_id": 10090, "disease": "", "pathway": " 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Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:22802073). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity) (PubMed:16980309). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The GARP Domain of the Rod CNG Channel's beta1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0044877 protein-containing complex binding;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005272 sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton;GO:0001750 photoreceptor outer segment;GO:0017071 intracellular cyclic nucleotide activated cation channel complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "E1AZ71-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AIR5-1", "uniprot_id": [ { "id": "NMD3A_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AIR5", "type": "external" } ], "mass": 127542.0, "length": 1135, "protein_name": "Glutamate receptor ionotropic, NMDA 3A", "gene_name": "Grin3a", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 3A isoform 1 precursor", "refseq_ac": [ { "id": "NP_001263284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284", "type": "external" } ], "gene_names_uniprotkb": "Grin3a; Kiaa1973", "gene_names_refseq": "6430537F04; A830097C19Rik; GluN3A; Grin3a; NMDAR-L; NMDAR3A; NR3A; mKIAA1973", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 3A; GluN3A; N-methyl-D-aspartate receptor subtype 3A; N-methyl-D-aspartate receptor; NMDAR-L; NMDAR3A; NR3A", "protein_names_refseq": "N-methyl-D-aspartate receptor subtype 3A; N-methyl-D-aspartate receptor; glutamate receptor ionotropic, NMDA 3A isoform 1 precursor; glutamate receptor ionotropic, NMDA 3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:242443); (R-MMU-9609736)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14983056;24297929;30899004;36997126;39256046", "class_list": "", "function": "Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth (By similarity). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (By similarity). GluN3A subunit also binds D-serine (By similarity). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929)., [UniProtKB, PubMed, UniProtKB]; Decrease in NMDA-receptor activity in alpha-neurexin-deficient synapses, [RefSeq, PubMed]; Dysfunction of GluN3A subunit is involved in depression-like behaviors through synaptic deficits., [RefSeq, PubMed]; GluN3A and Excitatory Glycine Receptors in the Adult Hippocampus. Erratum:[J Neurosci. 2024 Nov 20;44(47):e2031242024. doi: 10.1523/JNEUROSCI.2031-24.2024. PMID: 39542731] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A2AIR4;Q69Z52", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0051721 protein phosphatase 2A binding;GO:0004970 glutamate-gated receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0045471 response to ethanol;GO:0006816 calcium ion transport;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "A2AIR5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AWR3-1", "uniprot_id": [ { "id": "LYCHS_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AWR3", "type": "external" } ], "mass": 96347.0, "length": 868, "protein_name": "Lysosomal cholesterol signaling protein", "gene_name": "Gpr155", "organism": "Mouse", "refseq_name": "lysosomal cholesterol signaling protein isoform 1", "refseq_ac": [ { "id": "NP_001177226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177226", "type": "external" } ], "gene_names_uniprotkb": "Gpr155", "gene_names_refseq": "1110017O10Rik; DEPDC3; F730029F15Rik; Gpr155; LYCHOS; PGR22", "protein_names_uniprotkb": "Lysosomal cholesterol signaling protein; LYCHOS", "protein_names_refseq": "integral membrane protein GPR155; lysosomal cholesterol signaling protein isoform 1; lysosomal cholesterol signaling protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68526)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12679517;20537985;21750661;24789282", "class_list": "", "function": "Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (By similarity). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (By similarity). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (By similarity). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (By similarity)., [UniProtKB, UniProtKB]; Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. Publication Status: Online-Only, [RefSeq, PubMed]; This study reports the structural organization of mouse GPR155 gene and the generation of five variants (Variants 1-5) of GPR155 mRNA, including so far unknown four variants., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AWR2;D7RXL9;D7RXM0;Q14BN5;Q80UC0;Q8R0W2", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0050890 cognition;GO:0055085 transmembrane transport;GO:0071397 cellular response to cholesterol;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2AWR3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARV7-1", "uniprot_id": [ { "id": "A2ARV7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARV7", "type": "external" } ], "mass": 34983.0, "length": 303, "protein_name": "Predicted gene 14401", "gene_name": "Gm14401", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm14401", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 14401", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ARV7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6YK91-1", "uniprot_id": [ { "id": "F6YK91_MOUSE", "url": "https://www.uniprot.org/uniprot/F6YK91", "type": "external" } ], "mass": 38373.0, "length": 364, "protein_name": "Ankyrin repeat domain 65", "gene_name": "Ankrd65", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 65", "refseq_ac": [ { "id": "NP_001357751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357751", "type": "external" } ], "gene_names_uniprotkb": "Ankrd65; E230028L10Rik", "gene_names_refseq": "Ankrd65; E230028L10Rik; Gm439; Gm45", "protein_names_uniprotkb": "Ankyrin repeat domain 65", "protein_names_refseq": "ankyrin repeat domain-containing protein 65", "tax_id": 10090, "disease": "", "pathway": " (mmu:242805)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6YK91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0J9YTU8-1", "uniprot_id": [ { "id": "A0A0J9YTU8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0J9YTU8", "type": "external" } ], "mass": 8782.0, "length": 78, "protein_name": "LITAF domain containing", "gene_name": "Litafd", "organism": "Mouse", "refseq_name": "lITAF domain-containing protein", "refseq_ac": [ { "id": "NP_001311446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311446", "type": "external" } ], "gene_names_uniprotkb": "Litafd; Gm5767", "gene_names_refseq": "EG436336; Gm43786; Gm5767; Litafd", "protein_names_uniprotkb": "LITAF domain containing", "protein_names_refseq": "lITAF domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:436336)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0098560 cytoplasmic side of late endosome membrane", "go_biological_process": "GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0J9YTU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PUZ9-1", "uniprot_id": [ { "id": "E9PUZ9_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PUZ9", "type": "external" } ], "mass": 114066.0, "length": 1014, "protein_name": "PDZ domain containing RING finger 4", "gene_name": "Pdzrn4", "organism": "Mouse", "refseq_name": "PDZ domain-containing RING finger protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001158065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158065", "type": "external" } ], "gene_names_uniprotkb": "Pdzrn4", "gene_names_refseq": "1110017D07Rik; LNX4; Pdzrn4; SAMCAP3L; mKIAA3027", "protein_names_uniprotkb": "PDZ domain containing RING finger 4", "protein_names_refseq": "PDZ domain-containing RING finger protein 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239618)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PUZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60680-1", "uniprot_id": [ { "id": "IKKA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60680", "type": "external" } ], "mass": 84729.0, "length": 745, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "Chuk", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chuk; Ikka", "gene_names_refseq": "", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit alpha; 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IKK1; IkBKA; IkappaB kinase; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha", "protein_names_refseq": "", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); fetal encasement syndrome (Disease Ontology:DOID:0060647); prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); liver cancer (Disease Ontology:DOID:3571); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:12675); (R-MMU-1169091); (R-MMU-1810476); (R-MMU-198323); (R-MMU-202424); (R-MMU-2871837); (R-MMU-445989); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-9020702); (R-MMU-933542); (R-MMU-937039); (R-MMU-937041); (R-MMU-975144); (R-MMU-9758274); (R-MMU-9833482); (R-MMU-9860276); (R-MMU-9860927); (R-MMU-9909505)", "pathway_count": 23, "publication_count": 17, "publication_id_list": "10195894;10195895;10712233;10733566;12789342;14585990;16751795;18194271;19202066;20622870;21750661;30988283;34428180;7558004;8777433;9520401;9819420", "class_list": "", "function": "Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor. Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (PubMed:30988283). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80VU2;Q9D2X3", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0032727 positive regulation of interferon-alpha production;GO:0061847 response to cholecystokinin;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60680-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K012-1", "uniprot_id": [ { "id": "FBP1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K012", "type": "external" } ], "mass": 69885.0, "length": 605, "protein_name": "Formin-binding protein 1-like", "gene_name": "Fnbp1l", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fnbp1l; Toca1", "gene_names_refseq": "", "protein_names_uniprotkb": "Formin-binding protein 1-like; Toca-1; Transducer of Cdc42-dependent actin assembly protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:214459); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17114649;17242355;19144319;21183079;21750661;34428180;40021952", "class_list": "", "function": "Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U901", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0010324 membrane invagination;GO:0007165 signal transduction;GO:0006914 autophagy;GO:0060271 cilium assembly;GO:0006900 vesicle budding from membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K012-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T41-1", "uniprot_id": [ { "id": "GABR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80T41", "type": "external" } ], "mass": 105666.0, "length": 940, "protein_name": "Gamma-aminobutyric acid type B receptor subunit 2", "gene_name": "Gabbr2", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid type B receptor subunit 2 precursor", "refseq_ac": [ { "id": "NP_001074610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074610", "type": "external" } ], "gene_names_uniprotkb": "Gabbr2; Gm425; Gpr51", "gene_names_refseq": "GABABR2; Gabbr2; Gb2; Gm425; Gpr51", "protein_names_uniprotkb": "Gamma-aminobutyric acid type B receptor subunit 2; G protein-coupled receptor 51; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2", "protein_names_refseq": "gamma-aminobutyric acid (GABA) B receptor, 2; gamma-aminobutyric acid type B receptor subunit 2 precursor; ortholog of human G protein-coupled receptor 51 GPR51", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 59 (Disease Ontology:DOID:0080291); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:242425); (R-MMU-1296041); (R-MMU-418594); (R-MMU-420499); (R-MMU-977444); (R-MMU-997272)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10075644;12679517;16452087;20400944;21183079;21750661;30899004;32083308;32286880;32621101;33300544", "class_list": "", "function": "Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10075644). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (PubMed:20400944)., [UniProtKB, PubMed, UniProtKB, PubMed]; GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1., [RefSeq, PubMed]; MicroRNA-330 Directs Downregulation of the GABABR2 in the Pathogenesis of Pancreatic Cancer Pain., [RefSeq, PubMed]; Reelin signaling modulates GABAB receptor function in the neocortex., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AL05", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004965 G protein-coupled GABA receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0051932 synaptic transmission, GABAergic;GO:0150099 neuron-glial cell signaling", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q80T41-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG73-1", "uniprot_id": [ { "id": "FTM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG73", "type": "external" } ], "mass": 145000.0, "length": 1264, "protein_name": "Protein fantom", "gene_name": "Rpgrip1l", "organism": "Mouse", "refseq_name": "protein fantom", "refseq_ac": [ { "id": "NP_775607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775607", "type": "external" } ], "gene_names_uniprotkb": "Rpgrip1l; Ftm; Nphp8", "gene_names_refseq": "1700047E16Rik; 4931437C01; Ftm; Nphp8; Rpgrip1l", "protein_names_uniprotkb": "Protein fantom; Nephrocystin-8; RPGR-interacting protein 1-like protein; RPGRIP1-like protein", "protein_names_refseq": "RPGR-interacting protein 1-like protein; RPGRIP1-like protein; fantom; nephrocystin-8; protein fantom", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); anencephaly (Disease Ontology:DOID:0060668); Meckel syndrome 5 (Disease Ontology:DOID:0070119); retinitis pigmentosa 3 (Disease Ontology:DOID:0110414); Joubert syndrome 7 (Disease Ontology:DOID:0111002); intellectual disability (Disease Ontology:DOID:1059); nephronophthisis (Disease Ontology:DOID:12712); cystic kidney disease (Disease Ontology:DOID:2975); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:244585); (R-MMU-5610787); (R-MMU-5620912)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10501967;11956760;17553904;17558409;18256137;21565611;21750661;22927466;26150391;33625872", "class_list": "", "function": "As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling., [RefSeq, PubMed]; Examined Fto/Ftm expression in obese mice exposed to overfeeding,underfeeding and cold. Erratum:[Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1360-3], [RefSeq, PubMed]; Inactivation of mouse ortholog Rpgrip1l (Ftm) recapitulates the cerebral, renal and hepatic defects of cerebello-oculo-renal syndrome and Meckel syndrome., [RefSeq, PubMed]; Negatively regulates signaling through the G protein-coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (PubMed:22927466). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (PubMed:26150391)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X958", "ec_number_list": [], "go_molecular_function": "GO:0031870 thromboxane A2 receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0043584 nose development;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0001822 kidney development;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CG73-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21803-1", "uniprot_id": [ { "id": "FGFR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P21803", "type": "external" } ], "mass": 91984.0, "length": 821, "protein_name": "Fibroblast growth factor receptor 2", "gene_name": "Fgfr2", "organism": "Mouse", "refseq_name": "fibroblast growth factor receptor 2 isoform IIIc precursor", "refseq_ac": [ { "id": "NP_034337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034337", "type": "external" } ], "gene_names_uniprotkb": "Fgfr2; Bek; Ect1", "gene_names_refseq": "Bek; Fgfr-2; Fgfr-7; Fgfr2b; Fgfr2; Fgfr7; KGFRTr; KGFR; svs", "protein_names_uniprotkb": "Fibroblast growth factor receptor 2; 2.7.10.1; FGFR-2; KGFR; Keratinocyte growth factor receptor", "protein_names_refseq": "fibroblast growth factor receptor 2 isoform IIIc precursor; keratinocyte growth factor receptor", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); lacrimoauriculodentodigital syndrome 1 (Disease Ontology:DOID:0050331); Beare-Stevenson cutis gyrata syndrome (Disease Ontology:DOID:0050660); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); bent bone dysplasia syndrome 1 (Disease Ontology:DOID:0060992); bone disease (Disease Ontology:DOID:0080001); Antley-Bixler syndrome (Disease Ontology:DOID:0081289); Antley-Bixler syndrome without disordered steroidogenesis (Disease Ontology:DOID:0081290); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); prostate cancer (Disease Ontology:DOID:10283); intestinal atresia (Disease Ontology:DOID:10486); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); essential hypertension (Disease Ontology:DOID:10825); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); acrocephalosyndactylia (Disease Ontology:DOID:12960); primary pulmonary hypertension (Disease Ontology:DOID:14557); Pfeiffer syndrome (Disease Ontology:DOID:14705); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); Crouzon syndrome (Disease Ontology:DOID:2339); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); high grade glioma (Disease Ontology:DOID:3070); dysgerminoma (Disease Ontology:DOID:4441); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); female breast carcinoma (Disease Ontology:DOID:7843); intestinal volvulus (Disease Ontology:DOID:8445); Kaposi's sarcoma (Disease Ontology:DOID:8632)", "pathway": " (mmu:14183); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190375); (R-MMU-190377); (R-MMU-5654221); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654727); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 12, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10518547;10851026;12135917;1373495;15629145;1711190;1846048;21750661;21765038;2468999;31599954;34428180;34887587;8393815;8663044;9435295;9499422;9560232", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 35, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O55141;Q00389;Q61342", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0060365 coronal suture morphogenesis;GO:0048755 branching morphogenesis of a nerve;GO:0050678 regulation of epithelial cell proliferation;GO:0060523 prostate epithelial cord elongation;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P21803-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81069-1", "uniprot_id": [ { "id": "GABP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P81069", "type": "external" } ], "mass": 45658.0, "length": 414, "protein_name": "GA-binding protein subunit beta-2", "gene_name": "Gabpb2", "organism": "Mouse", "refseq_name": "GA-binding protein subunit beta-2", "refseq_ac": [ { "id": "NP_084161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084161", "type": "external" } ], "gene_names_uniprotkb": "Gabpb2", "gene_names_refseq": "1810015F01Rik; 5830427M07; 9430006E19Rik; A430024B14Rik; Gabpb2-1; Gabpb2", "protein_names_uniprotkb": "GA-binding protein subunit beta-2; GA-binding protein beta-2-1; GABP subunit beta-2-1; GABP subunit beta-2; GABPB-2; GABPB2-1", "protein_names_refseq": "GA-binding protein beta-2-1; GA-binding protein subunit beta-2; GABP subunit beta-2-1; GABP subunit beta-2; GABPB-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:213054)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16412436;18628204;20485683;21183079;22862946;31219806;7958862", "class_list": "", "function": "GABPbeta2 has a distinct role in restraining B cell expansion and humoral responses., [RefSeq, PubMed]; The findings identify the tetramer-forming GABPbeta2 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy., [RefSeq, PubMed]; Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E218;Q8CDA6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81069-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61089-1", "uniprot_id": [ { "id": "FZD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61089", "type": "external" } ], "mass": 79082.0, "length": 709, "protein_name": "Frizzled-6", "gene_name": "Fzd6", "organism": "Mouse", "refseq_name": "frizzled-6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001155966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155966", "type": "external" } ], "gene_names_uniprotkb": "Fzd6", "gene_names_refseq": "Fz6; Fzd6; rst", "protein_names_uniprotkb": "Frizzled-6; Fz-6; mFz6", "protein_names_refseq": "frizzled homolog 6; frizzled-6 isoform 1 precursor; frizzled-6; fz-6; mFz6", "tax_id": 10090, "disease": "nonsyndromic congenital nail disorder 1 (Disease Ontology:DOID:0080079)", "pathway": " (mmu:14368); (R-MMU-4086398); (R-MMU-4086400); (R-MMU-4641263)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10097073;10395542;16495441;21183079;21665003;21750661;25428506;30084848;34428180;8626800", "class_list": "", "function": "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031625 ubiquitin protein ligase binding;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042472 inner ear morphogenesis;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030168 platelet activation;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61089-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BY35-1", "uniprot_id": [ { "id": "FGD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BY35", "type": "external" } ], "mass": 74634.0, "length": 655, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 2", "gene_name": "Fgd2", "organism": "Mouse", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001153010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153010", "type": "external" } ], "gene_names_uniprotkb": "Fgd2", "gene_names_refseq": "Fgd2; Tcd-2; Tcd2; ZFYVE4; tcs-2; tcs2", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 2", "protein_names_refseq": "FYVE, RhoGEF and PH domain-containing protein 2 isoform 1; FYVE, RhoGEF and PH domain-containing protein 2; Fgd1 family, member 2; Fgd2-like protein; faciogenital dysplasia homolog 2; faciogenital dysplasia protein 2; t-complex distorter 2", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (mmu:26382); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10458911;17234881;21183079;21750661;30084848;30779550;34428180", "class_list": "", "function": "Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate., [UniProtKB, UniProtKB]; The t allele of Fgd2 is overexpressed in testis compared with wild type, a loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype t(h49), directly demonstrating the role of Fgd2 as Distorter., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88841;Q2L9D2;Q3U195;Q7TSE3;Q8VDH4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005856 cytoskeleton;GO:0031901 early endosome membrane", "go_biological_process": "GO:0046847 filopodium assembly;GO:0007010 cytoskeleton organization;GO:0043507 positive regulation of JUN kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BY35-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHX6-1", "uniprot_id": [ { "id": "FLNC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHX6", "type": "external" } ], "mass": 291119.0, "length": 2726, "protein_name": "Filamin-C", "gene_name": "Flnc", "organism": "Mouse", "refseq_name": "filamin-C isoform 1", "refseq_ac": [ { "id": "NP_001074654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074654", "type": "external" } ], "gene_names_uniprotkb": "Flnc; Abpl; Fln2", "gene_names_refseq": "1110055E19Rik; ABP-280; ABPL; Fln2; Flnc", "protein_names_uniprotkb": "Filamin-C; ABP-280-like protein; ABP-L; Actin-binding-like protein; FLN-C; Filamin-2; Gamma-filamin", "protein_names_refseq": "ABP-280-like protein; actin-binding protein 280; actin-binding-like protein; filamin-2; filamin-C isoform 1; filamin-C", "tax_id": 10090, "disease": "myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); hypertrophic cardiomyopathy 26 (Disease Ontology:DOID:0110327); distal myopathy 4 (Disease Ontology:DOID:0111190); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:68794); (R-MMU-446353)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10679933;11807098;15385448;16914736;19131326;20206623;22645316;23890175;24129315;24788674;24963132;25153642;25428506;27301331;31219806;34418053;36288343;36706168;37492967;37507081;39927985", "class_list": "", "function": "Filamin C is Essential for mammalian myocardial integrity. Publication Status: Online-Only, [RefSeq, PubMed]; Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function., [RefSeq, PubMed]; Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (By similarity). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (PubMed:16914736)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RY80;B9EKT2;Q6PAI6;Q9JJ38", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0045214 sarcomere organization;GO:0055001 muscle cell development;GO:0030029 actin filament-based process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8VHX6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R216-1", "uniprot_id": [ { "id": "FZD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R216", "type": "external" } ], "mass": 64995.0, "length": 592, "protein_name": "Frizzled-9", "gene_name": "Fzd9", "organism": "Mouse", "refseq_name": "frizzled-9 precursor", "refseq_ac": [ { "id": "NP_034376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034376", "type": "external" } ], "gene_names_uniprotkb": "Fzd9; Fzd3", "gene_names_refseq": "Fz9; Fzd9; mfz9", "protein_names_uniprotkb": "Frizzled-9; Fz-9; mFz3; mFz9", "protein_names_refseq": "frizzled homolog 9; frizzled-9 precursor; frizzled-9; fz-9; mFz3", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:14371)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10198163;15930120;21402791;24391920;24860427;33653688", "class_list": "", "function": "Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (PubMed:24860427). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (By similarity). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death (PubMed:15930120). Controls bone formation through non canonical Wnt signaling mediated via ISG15 (PubMed:21402791). Positively regulates bone regeneration through non canonical Wnt signaling (PubMed:24391920)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35494;Q9CX16;Q9R2B3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0043065 positive regulation of apoptotic process;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0043524 negative regulation of neuron apoptotic process;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R216-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV18-1", "uniprot_id": [ { "id": "GABR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV18", "type": "external" } ], "mass": 108216.0, "length": 960, "protein_name": "Gamma-aminobutyric acid type B receptor subunit 1", "gene_name": "Gabbr1", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_062312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062312", "type": "external" } ], "gene_names_uniprotkb": "Gabbr1", "gene_names_refseq": "GABAB1; GABAbR1; Gabbr1; bM573K1.1", "protein_names_uniprotkb": "Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1", "protein_names_refseq": "GABA-B receptor 1; GABA-B-R1; GABA-BR1b receptor; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor; gb1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); hypertension (Disease Ontology:DOID:10763); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:54393); (R-MMU-1296041); (R-MMU-418594); (R-MMU-420499); (R-MMU-977444); (R-MMU-997272)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10075644;10773016;11304760;11306808;14718537;17114649;20400944;21183079;21750661;25428506;30899004;31219806;33300544;34428180;37678443;39190359;9872744", "class_list": "", "function": "Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10075644, PubMed:10773016). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; GABAB1 receptor knockdown in prefrontal cortex induces behavioral aberrations associated with autism spectrum disorder in mice., [RefSeq, PubMed]; MPTP-induced denervation is associated with a decrease of GABA(B) receptors restricted to the substantia nigra pars compacta, [RefSeq, PubMed]; N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABABR1 mRNA in sepsis-associated encephalopathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGJ2;Q9WU48;Q9WV15;Q9WV16;Q9WV17", "ec_number_list": [], "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0046982 protein heterodimerization activity;GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0004965 G protein-coupled GABA receptor activity;GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0014048 regulation of glutamate secretion;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0008285 negative regulation of cell population proliferation;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q9WV18-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MR1-1", "uniprot_id": [ { "id": "GGYF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MR1", "type": "external" } ], "mass": 116238.0, "length": 1044, "protein_name": "GRB10-interacting GYF protein 1", "gene_name": "Gigyf1", "organism": "Mouse", "refseq_name": "GRB10-interacting GYF protein 1 isoform a", "refseq_ac": [ { "id": "NP_113596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113596", "type": "external" } ], "gene_names_uniprotkb": "Gigyf1; Kiaa4110; Perq1", "gene_names_refseq": "Gigyf1; Perq1; mKIAA4110", "protein_names_uniprotkb": "GRB10-interacting GYF protein 1; PERQ amino acid-rich with GYF domain-containing protein 1", "protein_names_refseq": "GRB10 interacting GYF protein 2; GRB10-interacting GYF protein 1 isoform a; PERQ amino acid rich, with GYF domain 1; PERQ amino acid-rich with GYF domain-containing protein 1", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:57330)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11239002;12771153;16452087;21183079;21750661;25428506;30084848;31219806;34428180;36210013;36924980", "class_list": "", "function": "Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice., [RefSeq, PubMed]; Identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling, [RefSeq, PubMed]; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q571A0;Q6Y7W9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045947 negative regulation of translational initiation;GO:0048009 insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99MR1-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61625-1", "uniprot_id": [ { "id": "GRID2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61625", "type": "external" } ], "mass": 113082.0, "length": 1007, "protein_name": "Glutamate receptor ionotropic, delta-2", "gene_name": "Grid2", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, delta-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032193", "type": "external" } ], "gene_names_uniprotkb": "Grid2", "gene_names_refseq": "B230104L07Rik; GluD2; GluRdelta2; Grid2; Lc; Lc; MMS10-AC; Ms10ac; cpr; ho; nmf408; tpr", "protein_names_uniprotkb": "Glutamate receptor ionotropic, delta-2; GluD2; GluR delta-2 subunit", "protein_names_refseq": "creeper; gluR delta-2 subunit; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2 isoform 1 precursor; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 18 (Disease Ontology:DOID:0080042)", "pathway": " (mmu:14804)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12372286;15207857;17027646;20395510;21183079;21410790;21750661;22220752;22645316;24357660;27276689;29782851;30899004;34678516;34936451;39052831;40885482;7506541;9285588", "class_list": "", "function": "Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system (By similarity). Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (PubMed:24357660). Promotes synaptogenesis and mediates the D-serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex (By similarity). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (PubMed:34936451). Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells (PubMed:24357660, PubMed:27276689)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A4QPG1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0060079 excitatory postsynaptic potential;GO:0035249 synaptic transmission, glutamatergic;GO:0060134 prepulse inhibition;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q61625-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7P3-1", "uniprot_id": [ { "id": "GLSK_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z7P3", "type": "external" } ], "mass": 73964.0, "length": 674, "protein_name": "Glutaminase kidney isoform, mitochondrial", "gene_name": "Gls", "organism": "Mouse", "refseq_name": "glutaminase kidney isoform, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001074550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074550", "type": "external" } ], "gene_names_uniprotkb": "Gls; Gls1; Kiaa0838", "gene_names_refseq": "6330442B14; B230365M23Rik; Gls", "protein_names_uniprotkb": "Glutaminase kidney isoform, mitochondrial; 3.5.1.2; GLS", "protein_names_refseq": "glutaminase kidney isoform, mitochondrial isoform 1", "tax_id": 10090, "disease": "CASGID syndrome (Disease Ontology:DOID:0061156); developmental and epileptic encephalopathy 71 (Disease Ontology:DOID:0112207); lymphangioleiomyomatosis (Disease Ontology:DOID:3319)", "pathway": " (mmu:14660); (R-MMU-210500); (R-MMU-5628897); (R-MMU-8964539)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16641247;16899818;21750661;22228304;22373647;23806337;23935106;27542409;30084848;33300544", "class_list": "", "function": "Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9PUF0;Q69ZX9", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0001967 suckling behavior;GO:0051289 protein homotetramerization;GO:0002087 regulation of respiratory gaseous exchange by nervous system process;GO:0007268 chemical synaptic transmission;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "D3Z7P3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68ED2-1", "uniprot_id": [ { "id": "GRM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68ED2", "type": "external" } ], "mass": 102219.0, "length": 915, "protein_name": "Metabotropic glutamate receptor 7", "gene_name": "Grm7", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 7 isoform 1 precursor", "refseq_ac": [ { "id": "NP_796302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796302", "type": "external" } ], "gene_names_uniprotkb": "Grm7; Gprc1g; Mglur7", "gene_names_refseq": "6330570A01Rik; C030018L03; E130018M02Rik; Gpr1g; Gprc1g; Grm7; SMN2; Tg(SMN2)89Ahmb; mGluR7", "protein_names_uniprotkb": "Metabotropic glutamate receptor 7; mGluR7", "protein_names_refseq": "G protein-coupled receptor GRM7; G protein-coupled receptor, family C, group 1, member G; mGlu7a receptor; metabotropic glutamate receptor 7 isoform 1 precursor; metabotropic glutamate receptor 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:108073); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21183079;21750661;31599954;33300544", "class_list": "", "function": "G protein-coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0008306 associative learning;GO:0030534 adult behavior;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q68ED2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70325-1", "uniprot_id": [ { "id": "GPX4_MOUSE", "url": "https://www.uniprot.org/uniprot/O70325", "type": "external" } ], "mass": 22229.0, "length": 197, "protein_name": "Phospholipid hydroperoxide glutathione peroxidase GPX4", "gene_name": "Gpx4", "organism": "Mouse", "refseq_name": "phospholipid hydroperoxide glutathione peroxidase GPX4 isoform B", "refseq_ac": [ { "id": "NP_001032830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032830", "type": "external" } ], "gene_names_uniprotkb": "Gpx4", "gene_names_refseq": "GPx-4; GSHPx-4; Gpx4; PHGPx; mtPHGPx; snGPx", "protein_names_uniprotkb": "Phospholipid hydroperoxide glutathione peroxidase GPX4; 1.11.1.12; 1.11.1.9; GPx-4; GSHPx-4; Glutathione peroxidase 4; PHGPx", "protein_names_refseq": "phospholipid hydroperoxide glutathione peroxidase GPX4 isoform B; phospholipid hydroperoxide glutathione peroxidase GPX4; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; sperm nuclei glutathione peroxidase", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); spondylometaphyseal dysplasia Sedaghatian type (Disease Ontology:DOID:0112298); pre-eclampsia (Disease Ontology:DOID:10591); nephrotic syndrome (Disease Ontology:DOID:1184); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); gastric adenocarcinoma (Disease Ontology:DOID:3717); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:625249); (R-MMU-2142712); (R-MMU-2142770); (R-MMU-9018676); (R-MMU-9018896); (R-MMU-9020265); (R-MMU-9023661)", "pathway_count": 7, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10100845;10341094;11344099;12566075;12745070;1668477;17503194;18762024;19417079;19783653;19890015;21750661;22207760;22645316;24439385;24599700;24788674;25402683;25824823;25922076;27710939;28204974;29290465;30718432;31219806;33300544;34428180;35820727;39778769;9370288", "class_list": "", "function": "Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (PubMed:29290465). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:12566075). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:12566075, PubMed:24439385, PubMed:25402683, PubMed:25922076, PubMed:29290465). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (PubMed:29290465). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (PubMed:29290465). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (PubMed:12566075). Required for normal sperm development and male fertility (PubMed:19783653, PubMed:25922076). Essential for maturation and survival of photoreceptor cells (PubMed:22207760). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (PubMed:25824823). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can also reduce small soluble hydroperoxides such as H2O2 and tert-butyl hydroperoxide (PubMed:12566075)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Mitochondrial GPx4 confers the vital role of selenium in mammalian male fertility, [RefSeq, PubMed]; Required for male fertility by stabilizing the condensed chromatin in sperm nuclei (PubMed:12566075)., [UniProtKB, PubMed]; Required for male fertility by stabilizing the condensed chromatin in sperm nuclei., [UniProtKB, UniProtKB]; Specifically able to suppress the production of leukotriene and prostaglandin in response to several stimuli by reducing fatty acid hydroperoxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Specifically required to prevent mitochondrial cell death by mediating reduction of cardiolipin hydroperoxide (By similarity). Also required for normal sperm development and male fertility (PubMed:19417079)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. Pseudogenes of this locus have been identified on chromosomes 10 and 17. [provided by RefSeq, Jan 2019]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35560;Q8K4U8;Q91XR9;Q9JK35", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity;GO:0008430 selenium binding;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0016358 dendrite development;GO:0032496 response to lipopolysaccharide;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "O70325-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43277-1", "uniprot_id": [ { "id": "H13_MOUSE", "url": "https://www.uniprot.org/uniprot/P43277", "type": "external" } ], "mass": 22100.0, "length": 221, "protein_name": "Histone H1.3", "gene_name": "H1-3", "organism": "Mouse", "refseq_name": "histone H1.3", "refseq_ac": [ { "id": "NP_663759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663759", "type": "external" } ], "gene_names_uniprotkb": "H1-3; H1f3; Hist1h1d", "gene_names_refseq": "H1-3; H1.3; H1D; H1f3; H1s-4; Hist1h1d", "protein_names_uniprotkb": "Histone H1.3; H1 VAR.4; H1d", "protein_names_refseq": "H1 VAR.4; H1 histone family, member 3; histone 1, H1d; histone 1, family 3; histone H1.3; histone cluster 1, H1d", "tax_id": 10090, "disease": "", "pathway": " (mmu:14957); (R-MMU-140342); (R-MMU-2559584)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "12408966;12808097;17242355;23806337;24463520;26495903;27105115;28011936;29125738;29187734;30779550;32152506;33300544;33725478;35984892;36288343;39927985;8589518;8639656;8858344", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:12808097). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:12808097). Together with histone H1-3, histone H1-3 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-3 has a high affinity for introns and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (By similarity). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (PubMed:12808097)., [UniProtKB, UniProtKB, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6M4", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P43277-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61627-1", "uniprot_id": [ { "id": "GRID1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61627", "type": "external" } ], "mass": 112210.0, "length": 1009, "protein_name": "Glutamate receptor ionotropic, delta-1", "gene_name": "Grid1", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, delta-1 precursor", "refseq_ac": [ { "id": "NP_032192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032192", "type": "external" } ], "gene_names_uniprotkb": "Grid1", "gene_names_refseq": "GluD1; GluRdelta1; Grid1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, delta-1; GluD1; GluR delta-1 subunit", "protein_names_refseq": "gluR delta-1 subunit; glutamate receptor delta-1 subunit; glutamate receptor ionotropic, delta-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14803)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;1372507;22220752;22645316;22872234;27418511;28696429;30899004;32848054;33300544;34135511;34418053;34685624;34936451;39052831;40885482", "class_list": "", "function": "Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain. Publication Status: Online-Only, [RefSeq, PubMed]; Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction (PubMed:34135511). In the presence of NRX1B-CBLN1, forms cation-selective channels that are proposed to be gated by glycine and D-serine (PubMed:34936451). However, recent research disputes this ligand-gated cation channel activity (PubMed:39052831). Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons (PubMed:28696429). Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUL5", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0035176 social behavior;GO:0050804 modulation of chemical synaptic transmission;GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q61627-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IR34-1", "uniprot_id": [ { "id": "GPSM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IR34", "type": "external" } ], "mass": 74362.0, "length": 673, "protein_name": "G protein-signaling modulator 1", "gene_name": "Gpsm1", "organism": "Mouse", "refseq_name": "G-protein-signaling modulator 1 isoform 2", "refseq_ac": [ { "id": "NP_001186075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186075", "type": "external" } ], "gene_names_uniprotkb": "Gpsm1; Ags3; C10a", "gene_names_refseq": "1810037C22Rik; Ags3; Gpsm1", "protein_names_uniprotkb": "G protein-signaling modulator 1; Activator of G protein signaling 3", "protein_names_refseq": "G-protein-signaling modulator 1 isoform 2; G-protein-signaling modulator 1; activator of G-protein signaling 3", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:67839); (R-MMU-418594)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10969064;12719437;12925752;15345747;16009138;21183079;21750661;22117215;24129315;36288343;36434066;37017303;37979657", "class_list": "", "function": "AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. Publication Status: Online-Only, [RefSeq, PubMed]; Cortical localization in mitotic cell culture systems and requirement for normal cell cycle progression, [RefSeq, PubMed]; GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity., [RefSeq, PubMed]; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction., [UniProtKB, PubMed]; The GPR motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase activator as initially suggested., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AIX7;A2AIX8;A2AIX9;Q61366;Q8BUK4;Q8BX78;Q8R0R9", "ec_number_list": [], "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0016239 positive regulation of macroautophagy;GO:0034260 negative regulation of GTPase activity;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6IR34-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMI4-1", "uniprot_id": [ { "id": "GEN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMI4", "type": "external" } ], "mass": 101779.0, "length": 908, "protein_name": "Flap endonuclease GEN homolog 1", "gene_name": "Gen1", "organism": "Mouse", "refseq_name": "flap endonuclease GEN homolog 1", "refseq_ac": [ { "id": "NP_796305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796305", "type": "external" } ], "gene_names_uniprotkb": "Gen1", "gene_names_refseq": "5830483C08Rik; Gen1", "protein_names_uniprotkb": "Flap endonuclease GEN homolog 1; 3.1.-.-", "protein_names_refseq": "Gen homolog 1, endonuclease; flap endonuclease GEN homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:209334); (R-MMU-5693568)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;24980922;27010503;27383418;32226308;34922199;36870240", "class_list": "", "function": "Disruption of Gen1 causes ectopic budding and kidney hypoplasia in mice., [RefSeq, PubMed]; Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction. Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA. Also has endonuclease activity on 5'-flap and replication fork (RF) DNA substrates., [UniProtKB, UniProtKB]; Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2[PB/+] Gen1[PB/+] mice., [RefSeq, PubMed]; Study found that a Gen1 mutation alone did not affect DNA repair or meiotic recombination in mice; it caused synthetic lethality when combined with Eme1 mutations at an early embryonic stage. Also, combination of Gen1 and Eme1 mutations makes embryonic fibroblasts more sensitive to DNA damage & mice less capable of meiotic recombination. These results indicate that Gen1 and Eme1 are functionally redundant in mice., [RefSeq, PubMed]; The results suggest that GEN1 may play an important role in the development of mammary gland., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR04;Q3TYY2;Q5CZW6;Q8C0J0", "ec_number_list": [ { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0000400 four-way junction DNA binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0071139 resolution of DNA recombination intermediates", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BMI4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921D9-1", "uniprot_id": [ { "id": "GRHL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921D9", "type": "external" } ], "mass": 70176.0, "length": 618, "protein_name": "Grainyhead-like protein 1 homolog", "gene_name": "Grhl1", "organism": "Mouse", "refseq_name": "grainyhead-like protein 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_001154878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154878", "type": "external" } ], "gene_names_uniprotkb": "Grhl1; Mgr; Tcfcp2l2", "gene_names_refseq": "Grhl1; LBP-32; MGR; Tcfcp2l2", "protein_names_uniprotkb": "Grainyhead-like protein 1 homolog; Transcription factor CP2-like 2; Transcription factor LBP-32", "protein_names_refseq": "grainyhead like 1; grainyhead-like 1; grainyhead-like protein 1 homolog isoform 1; grainyhead-like protein 1 homolog; mammalian grainyhead; p61 MGR; p70 MGR; transcription factor CP2-like 2; transcription factor LBP-32", "tax_id": 10090, "disease": "", "pathway": " (mmu:195733)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12175488;12666198;16831572;18288204;21081122;21750661;22872234;24586629;30193734;31219806;32848054;34203471;34428180;35013237;36210013;36688410;36852467", "class_list": "", "function": "Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Publication Status: Online-Only, [RefSeq, PubMed]; Grainyhead like 1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals and is epidermally expressed, [RefSeq, PubMed]; Grhl genes are highly expressed in the developing epidermis., [RefSeq, PubMed]; Grhl2 regulation of SPINT1 expression controls salivary gland development, [RefSeq, PubMed]; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:18288204, PubMed:21081122). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier (PubMed:18288204, PubMed:24586629). There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (PubMed:21081122). May play a role in regulating glucose homeostasis and insulin signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5C1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061436 establishment of skin barrier;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q921D9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43406-1", "uniprot_id": [ { "id": "ITAV_MOUSE", "url": "https://www.uniprot.org/uniprot/P43406", "type": "external" } ], "mass": 115360.0, "length": 1044, "protein_name": "Integrin alpha-V", "gene_name": "Itgav", "organism": "Mouse", "refseq_name": "integrin alpha-V isoform 1 precursor", "refseq_ac": [ { "id": "NP_032428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032428", "type": "external" } ], "gene_names_uniprotkb": "Itgav", "gene_names_refseq": "1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; Itgav", "protein_names_uniprotkb": "Integrin alpha-V; Vitronectin receptor subunit alpha", "protein_names_refseq": "alpha v integrin; integrin alpha-V isoform 1 precursor; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); corneal neovascularization (Disease Ontology:DOID:11382); ischemia (Disease Ontology:DOID:326); hyperglycemia (Disease Ontology:DOID:4195); coronary stenosis (Disease Ontology:DOID:4248); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:16410); (R-MMU-1236973); (R-MMU-1566948); (R-MMU-210990); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-4420097); (R-MMU-445144); (R-MMU-6798695); (R-MMU-9860927)", "pathway_count": 13, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10025398;11323698;11805835;19349973;19656770;21750661;22872234;24935931;25127859;30899004;31219806;33300544;37828378;38016540;40885482;8601592;9827803", "class_list": "", "function": "The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF (PubMed:10025398, PubMed:9827803). They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (PubMed:9827803). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (By similarity). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398, PubMed:25127859). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity). ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation (PubMed:11323698). ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a (PubMed:24935931). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 22, "disease_count": 8, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "A2AKI6", "ec_number_list": [], "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0038132 neuregulin binding;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0010888 negative regulation of lipid storage;GO:0001525 angiogenesis;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P43406-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXK7-1", "uniprot_id": [ { "id": "CPSF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXK7", "type": "external" } ], "mass": 77505.0, "length": 684, "protein_name": "Cleavage and polyadenylation specificity factor subunit 3", "gene_name": "Cpsf3", "organism": "Mouse", "refseq_name": "cleavage and polyadenylation specificity factor subunit 3 isoform 1", "refseq_ac": [ { "id": "NP_061283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061283", "type": "external" } ], "gene_names_uniprotkb": "Cpsf3; Cpsf73", "gene_names_refseq": "Cpsf3", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 3; 3.1.27.-; CPSF 73 kDa subunit; Cleavage and polyadenylation specificity factor 73 kDa subunit; mRNA 3'-end-processing endonuclease CPSF-73", "protein_names_refseq": "CPSF 73 kDa subunit; cleavage and polyadenylation specificity factor 73 kDa subunit; cleavage and polyadenylation specificity factor subunit 3 isoform 1; cleavage and polyadenylation specificity factor subunit 3; mRNA 3'-end-processing endonuclease CPSF-73", "tax_id": 10090, "disease": "", "pathway": " (mmu:54451); (R-MMU-159231); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "16115198;16213211;18955505;19470752;21183079;21750661;25605945;26255770;29804889;31219806;34082786;34428180;36519931", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3' endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (PubMed:26255770, PubMed:29804889). Required for entering/progressing through S-phase of the cell cycle (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1. Publication Status: Online-Only, [RefSeq, PubMed]; UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIM0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0004534 5'-3' RNA exonuclease activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:1990904 ribonucleoprotein complex;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0031124 mRNA 3'-end processing;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QXK7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0R4-1", "uniprot_id": [ { "id": "ITSN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0R4", "type": "external" } ], "mass": 194297.0, "length": 1714, "protein_name": "Intersectin-1", "gene_name": "Itsn1", "organism": "Mouse", "refseq_name": "intersectin-1 isoform 2", "refseq_ac": [ { "id": "NP_001103745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103745", "type": "external" } ], "gene_names_uniprotkb": "Itsn1; Ese1; Itsn", "gene_names_refseq": "Ehsh1; Ese1; Itsn1; Itsn; Sh3p17", "protein_names_uniprotkb": "Intersectin-1; EH and SH3 domains protein 1", "protein_names_refseq": "EH and SH3 domains protein 1; Eh domain, SH3 domain regulator of endocytosis 1; intersectin (SH3 domain protein 1A); intersectin-1 isoform 2; intersectin-1; intersectin-L", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:16443); (R-MMU-193648); (R-MMU-3928662); (R-MMU-416482); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9013148); (R-MMU-9013406); (R-MMU-9013408)", "pathway_count": 9, "publication_count": 22, "publication_id_list": "10064583;11744688;15345747;16452087;16914641;17242355;18630941;18676989;19144319;20448150;20585582;21183079;21750661;23633571;26797119;29599122;31219806;32848054;34428180;34678516;36583994;40885482", "class_list": "", "function": "Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:10064583). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (PubMed:16914641). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways (PubMed:16914641). In chromaffin cells, required for normal exocytosis of catecholamines (PubMed:18676989). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed:23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in synaptic vesicle endocytosis in brain neurons., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "F8VQE5;Q9R143", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0098871 postsynaptic actin cytoskeleton;GO:0097708 intracellular vesicle;GO:0005635 nuclear envelope", "go_biological_process": "GO:2001288 positive regulation of caveolin-mediated endocytosis;GO:0006897 endocytosis;GO:0007267 cell-cell signaling;GO:0015031 protein transport;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9Z0R4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61851-1", "uniprot_id": [ { "id": "FGFR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61851", "type": "external" } ], "mass": 87758.0, "length": 801, "protein_name": "Fibroblast growth factor receptor 3", "gene_name": "Fgfr3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fgfr3; Mfr3; Sam3", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor receptor 3; 2.7.10.1; FGFR-3; Heparin-binding growth factor receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal dominant disease (Disease Ontology:DOID:0050736); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); tonsil squamous cell carcinoma (Disease Ontology:DOID:0050920); scoliosis (Disease Ontology:DOID:0060249); Muenke Syndrome (Disease Ontology:DOID:0060703); bone disease (Disease Ontology:DOID:0080001); hypochondroplasia (Disease Ontology:DOID:0080041); lacrimoauriculodentodigital syndrome 2 (Disease Ontology:DOID:0081371); SADDAN (Disease Ontology:DOID:0111158); camptodactyly-tall stature-scoliosis-hearing loss syndrome (Disease Ontology:DOID:0111160); Crouzon syndrome-acanthosis nigricans syndrome (Disease Ontology:DOID:0111161); epidermal nevus (Disease Ontology:DOID:0111162); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); thanatophoric dysplasia (Disease Ontology:DOID:13481); breast cancer (Disease Ontology:DOID:1612); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); high grade glioma (Disease Ontology:DOID:3070); acanthosis nigricans (Disease Ontology:DOID:3138); chondrosarcoma (Disease Ontology:DOID:3371); Merkel cell carcinoma (Disease Ontology:DOID:3965); bladder urothelial carcinoma (Disease Ontology:DOID:4006); achondroplasia (Disease Ontology:DOID:4480); chronic myeloid leukemia (Disease Ontology:DOID:8552); tongue cancer (Disease Ontology:DOID:8649); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-MMU-109704); (R-MMU-1257604); (R-MMU-190371); (R-MMU-190372); (R-MMU-5654227); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654732); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11827956;1379594;14699054;21183079;21561999;21750661;30899004;7512569;8382556;8601314;8630492;8663044;9716527", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B. Plays a role in postnatal lung development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 28, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q61564;Q63834", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1904383 response to sodium phosphate;GO:0061144 alveolar secondary septum development;GO:0061430 bone trabecula morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61851-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89053-1", "uniprot_id": [ { "id": "COR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/O89053", "type": "external" } ], "mass": 50989.0, "length": 461, "protein_name": "Coronin-1A", "gene_name": "Coro1a", "organism": "Mouse", "refseq_name": "coronin-1A", "refseq_ac": [ { "id": "NP_001288303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288303", "type": "external" } ], "gene_names_uniprotkb": "Coro1a; Coro1", "gene_names_refseq": "Clabp; Coro1a; Lmb3; TACO; p57", "protein_names_uniprotkb": "Coronin-1A; Clipin-A; Coronin-like protein A; Coronin-like protein p57; TACO; Tryptophan aspartate-containing coat protein", "protein_names_refseq": "clipin-A; coronin 1; coronin-1A; coronin-like actin binding protein; coronin-like protein A; coronin-like protein p57; tryptophan aspartate-containing coat protein", "tax_id": 10090, "disease": "coronin-1A deficiency (Disease Ontology:DOID:0060019); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014)", "pathway": " (mmu:12721)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10338208;16172398;16407068;19144319;20937706;21183079;21750661;21844203;23100250;26495903;28011936;30779550;31599954;33300544;34428180;37507081;39627609;40684658;9778037;9798653", "class_list": "", "function": "May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes., [UniProtKB, PubMed]; This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMU0;Q9R1Y8;Q9R288", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005884 actin filament", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O89053-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35491-1", "uniprot_id": [ { "id": "CLK2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35491", "type": "external" } ], "mass": 59987.0, "length": 499, "protein_name": "Dual specificity protein kinase CLK2", "gene_name": "Clk2", "organism": "Mouse", "refseq_name": "dual specificity protein kinase CLK2 isoform 1", "refseq_ac": [ { "id": "NP_031738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031738", "type": "external" } ], "gene_names_uniprotkb": "Clk2", "gene_names_refseq": "Clk2", "protein_names_uniprotkb": "Dual specificity protein kinase CLK2; 2.7.12.1; CDC-like kinase 2", "protein_names_refseq": "dual specificity protein kinase CLK2 isoform 1; dual specificity protein kinase CLK2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12748)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "15010457;20074525;21183079;21329884;21750661;28089567;29575149;30084848;32782141;34428180;37635967;38724505;9307018;9852100", "class_list": "", "function": "CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion. Publication Status: Online-Only, [RefSeq, PubMed]; CLK2 is a regulatory component of diet-induced thermogenesis in brown adipose tissue., [RefSeq, PubMed]; CLK2 mediates IkappaBalpha-independent early termination of NF-kappaB activation by inducing cytoplasmic redistribution and degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; High CLK2 expression is associated with obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q721", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0032526 response to retinoic acid;GO:0046777 protein autophosphorylation;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35491-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A571BFV9-1", "uniprot_id": [ { "id": "A0A571BFV9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A571BFV9", "type": "external" } ], "mass": 17313.0, "length": 146, "protein_name": "IQ motif containing F6", "gene_name": "Iqcf6", "organism": "Mouse", "refseq_name": "IQ domain-containing protein F6", "refseq_ac": [ { "id": "NP_001095098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095098", "type": "external" } ], "gene_names_uniprotkb": "Iqcf6", "gene_names_refseq": "100041096; Iqcf6", "protein_names_uniprotkb": "IQ motif containing F6", "protein_names_refseq": "IQ domain-containing protein F6", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041096)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A571BFV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70552-1", "uniprot_id": [ { "id": "BTG4_MOUSE", "url": "https://www.uniprot.org/uniprot/O70552", "type": "external" } ], "mass": 28613.0, "length": 250, "protein_name": "Protein BTG4", "gene_name": "Btg4", "organism": "Mouse", "refseq_name": "protein BTG4", "refseq_ac": [ { "id": "NP_062366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062366", "type": "external" } ], "gene_names_uniprotkb": "Btg4; Pc3b", "gene_names_refseq": "Btg4; PC3B", "protein_names_uniprotkb": "Protein BTG4; BTG family member 4; Protein PC3b", "protein_names_refseq": "B cell translocation gene 4; BTG family member 4; protein BTG4; protein PC3b", "tax_id": 10090, "disease": "", "pathway": " (mmu:56057)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10995567;21750661;27065194;36880525", "class_list": "", "function": "Adapter protein that bridges CNOT7, a catalytic subunit of the CCR4-NOT complex, to EIF4E, and facilitates maternal mRNAs decay during the maturation of oocytes and in the fertilized egg (PubMed:27065194). It is therefore required for the maternal-zygotic transition (MZT), zygotic cleavage and initiation of embryonic development (PubMed:27065194)., [UniProtKB, PubMed]; Bioinformatic analysis of the clinicopathological and prognostic significance of oocyte-arresting BTG4 mRNA expression in gynecological cancers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925T9", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045930 negative regulation of mitotic cell cycle;GO:0160021 maternal-to-zygotic transition of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70552-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62812-1", "uniprot_id": [ { "id": "GBRA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P62812", "type": "external" } ], "mass": 51754.0, "length": 455, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-1", "gene_name": "Gabra1", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_034380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034380", "type": "external" } ], "gene_names_uniprotkb": "Gabra1; Gabra-1", "gene_names_refseq": "GABAA-alpha1; GABAAR-alpha1; Gabra-1; Gabra1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1; GABAAR subunit alpha-1", "protein_names_refseq": "GABA(A) receptor subunit alpha-1; GABAA alpha 1; GABAAR alpha1; GABAAR subunit alpha-1; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; gamma-aminobutyric acid receptor subunit alpha-1 precursor; gamma-aminobutyric acid receptor subunit alpha-1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 19 (Disease Ontology:DOID:0080431); hepatic encephalopathy (Disease Ontology:DOID:13413); generalized epilepsy (Disease Ontology:DOID:1827); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (mmu:14394); (R-MMU-977443)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12106288;1356407;16380713;16945976;1848528;21750661;25348603;25422464;25579817;27129275;30899004;31601770;33300544;34428180", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:27129275). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-1/GABRA1-containing GABAARs are largely synaptic (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (PubMed:25348603). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (PubMed:16945976, PubMed:25422464)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P18504", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0050809 diazepam binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0030659 cytoplasmic vesicle membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0071420 cellular response to histamine;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P62812-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A078-1", "uniprot_id": [ { "id": "CE290_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A078", "type": "external" } ], "mass": 289077.0, "length": 2472, "protein_name": "Centrosomal protein of 290 kDa", "gene_name": "Cep290", "organism": "Mouse", "refseq_name": "centrosomal protein of 290 kDa isoform 2", "refseq_ac": [ { "id": "NP_666121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666121", "type": "external" } ], "gene_names_uniprotkb": "Cep290; Kiaa0373; Nphp6", "gene_names_refseq": "Cep290; Nphp6; b2b1454Clo; b2b1752Clo", "protein_names_uniprotkb": "Centrosomal protein of 290 kDa; Bardet-Biedl syndrome 14 protein homolog; Cep290; Nephrocystin-6", "protein_names_refseq": "Bardet-Biedl syndrome 14 protein homolog; centrosomal protein of 290 kDa isoform 2; centrosomal protein of 290 kDa; nephrocystin-6", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Senior-Loken syndrome (Disease Ontology:DOID:0050576); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 4 (Disease Ontology:DOID:0070118); Bardet-Biedl syndrome 14 (Disease Ontology:DOID:0110136); Leber congenital amaurosis 10 (Disease Ontology:DOID:0110291); Joubert syndrome 5 (Disease Ontology:DOID:0111000); Leber congenital amaurosis (Disease Ontology:DOID:14791); cystic kidney disease (Disease Ontology:DOID:2975); kidney disease (Disease Ontology:DOID:557); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:216274); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6798695); (R-MMU-8854518)", "pathway_count": 9, "publication_count": 18, "publication_id_list": "16632484;16682970;16682973;17705300;17898177;21565611;21623382;21725307;21750661;23807208;23943788;31219806;34418053;34428180;34520396;35820727;36210013;39627609", "class_list": "", "function": "A CEP290/NPHP6 mutation perturbs its interaction with RPGR and results in early-onset retinal degeneration, [RefSeq, PubMed]; CEP290 is a key mediator involved in G protein trafficking. The assessment of olfactory function can, therefore, serve as a useful diagnostic tool for genetic screening of certain syndromic ciliary diseases., [RefSeq, PubMed]; Identified mutations in the CEP290 gene in five families with variable neurological, retinal and renal manifestations, [RefSeq, PubMed]; Involved in early and late steps in cilia formation (PubMed:21565611). Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (By similarity). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (By similarity). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (PubMed:16632484). Required for efficient recruitment of RAB8A to primary cilium (By similarity). In the ciliary transition zone is part of the tectonic-like complex (also named B9 complex) which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (PubMed:21725307). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (By similarity). Activates ATF4-mediated transcription (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP290. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIB8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0015031 protein transport;GO:0090316 positive regulation of intracellular protein transport;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6A078-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59242-1", "uniprot_id": [ { "id": "CING_MOUSE", "url": "https://www.uniprot.org/uniprot/P59242", "type": "external" } ], "mass": 136447.0, "length": 1191, "protein_name": "Cingulin", "gene_name": "Cgn", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cgn; Kiaa1319", "gene_names_refseq": "", "protein_names_uniprotkb": "Cingulin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:70737); (R-MMU-2173791)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15292197;17242355;21183079;21750661;30016717;34887587", "class_list": "", "function": "Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05BC4;Q69ZM0;Q6P2K0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0016459 myosin complex", "go_biological_process": "GO:0070830 bicellular tight junction assembly;GO:0000226 microtubule cytoskeleton organization;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P59242-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9EHT4-1", "uniprot_id": [ { "id": "CLIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/B9EHT4", "type": "external" } ], "mass": 59587.0, "length": 547, "protein_name": "CAP-Gly domain-containing linker protein 3", "gene_name": "Clip3", "organism": "Mouse", "refseq_name": "CAP-Gly domain-containing linker protein 3", "refseq_ac": [ { "id": "NP_001074583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074583", "type": "external" } ], "gene_names_uniprotkb": "Clip3; Clipr59", "gene_names_refseq": "1500005P14Rik; Clip3; Clipr-59", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 3; CLIP-170-related 59 kDa protein; CLIPR-59; Cytoplasmic linker protein 170-related 59 kDa protein", "protein_names_refseq": "CAP-Gly domain-containing linker protein 3; CLIP-170-related 59 kDa protein; clip-170 related protein 59 kDa; cytoplasmic linker protein 170-related 59 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76686); (R-MMU-5357905)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19139280;20485683;21183079;21750661;22689584;23482493;25572395;26198635;31219806;37828378", "class_list": "", "function": "Because ClipR-59 also interacts with Akt and enhances the interaction between Akt and AS160, we suggest that ClipR-59 functions as a scaffold protein to facilitate Akt-mediated AS160 phosphorylation, thereby regulating glucose transport, [RefSeq, PubMed]; CLIPR-59 is involved in the stabilization of specific motor axons at the neuromuscular junction during mouse late embryogenesis and its role is crucial for mouse perinatal development. Erratum:[Development. 2013 Jun;140(11):2444], [RefSeq, PubMed]; ClipR-59 functions as a scaffold protein that interacts with phospho-Akt and recruits active Akt on the membrane and may play an important role in adipocyte glucose transport., [RefSeq, PubMed]; Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion., [RefSeq, PubMed]; Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNI1;Q9DB67", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding;GO:0035594 ganglioside binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0032588 trans-Golgi network membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0098840 protein transport along microtubule;GO:0001934 positive regulation of protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B9EHT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BS45-1", "uniprot_id": [ { "id": "IFT56_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BS45", "type": "external" } ], "mass": 64151.0, "length": 554, "protein_name": "Intraflagellar transport protein 56", "gene_name": "Ift56", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 56", "refseq_ac": [ { "id": "NP_705828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705828", "type": "external" } ], "gene_names_uniprotkb": "Ift56; Hop; Ttc26", "gene_names_refseq": "9330141E21Rik; 9430097H08Rik; Ift56; Ttc26; hop; hpy", "protein_names_uniprotkb": "Intraflagellar transport protein 56; Protein hop-sterile; TPR repeat protein 26; Tetratricopeptide repeat protein 26", "protein_names_refseq": "TPR repeat protein 26; hydrocephalic-polydactyl; intraflagellar transport protein 56; protein hop-sterile; tetratricopeptide repeat domain 26; tetratricopeptide repeat protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:264134); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;22718903;22872234;24596149;25340710;28264835;31595528;35210288", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU (PubMed:22718903, PubMed:25340710). Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme (PubMed:28264835)., [UniProtKB, PubMed, PubMed, PubMed]; Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26. Publication Status: Online-Only, [RefSeq, PubMed]; These studies define a distinct and novel role for IFT56 in IFTB complex integrity that is crucial for cilia structure and function and, ultimately, animal development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0015031 protein transport;GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0035735 intraciliary transport involved in cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BS45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58462-1", "uniprot_id": [ { "id": "FOXP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P58462", "type": "external" } ], "mass": 78833.0, "length": 705, "protein_name": "Forkhead box protein P1", "gene_name": "Foxp1", "organism": "Mouse", "refseq_name": "forkhead box protein P1 isoform 2", "refseq_ac": [ { "id": "NP_001184250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184250", "type": "external" } ], "gene_names_uniprotkb": "Foxp1", "gene_names_refseq": "3110052D19Rik; 4932443N09Rik; Foxp1", "protein_names_uniprotkb": "Forkhead box protein P1; Forkhead-related transcription factor 1", "protein_names_refseq": "forkhead box protein P1 isoform 2; forkhead box protein P1; forkhead-related transcription factor 1", "tax_id": 10090, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); complex cortical dysplasia with other brain malformations (Disease Ontology:DOID:0090131); intellectual disability-severe speech delay-mild dysmorphism syndrome (Disease Ontology:DOID:0111331); trichostrongyloidiasis (Disease Ontology:DOID:1255); Huntington's disease (Disease Ontology:DOID:12858); congenital heart disease (Disease Ontology:DOID:1682); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); peritonitis (Disease Ontology:DOID:8283); Barrett's esophagus (Disease Ontology:DOID:9206); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:108655)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11358962;12687690;14516685;14701752;16819554;18662545;18667151;19224205;20173027;20175877;20713518;21750661;21924763;22517741;22675208;23946441;24859450;25428506;30084848;32782141;32848054;34428180;36852467;39627609;40885482", "class_list": "", "function": "Foxp1 mRNA is most highly expressed in developing and mature basal ganglia and is also observed in the cerebral cortex (layers 3-5), hippocampus (CA1), and thalamus., [RefSeq, PubMed]; Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (By similarity). Promotes ESC self-renewal and pluripotency (PubMed:21924763)., [UniProtKB, PubMed, UniProtKB]; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (PubMed:11358962, PubMed:14701752). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2 (PubMed:11358962, PubMed:22675208). Essential transcriptional regulator of B-cell development (PubMed:16819554). Involved in regulation of cardiac muscle cell proliferation (PubMed:20713518). Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins (PubMed:18662545, PubMed:18667151). Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3 (PubMed:20175877). Negatively regulates the differentiation of T follicular helper cells T(FH)s (PubMed:24859450). Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (PubMed:23946441). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6P221;Q8C5V2;Q8CCD9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:1904263 positive regulation of TORC1 signaling;GO:0030316 osteoclast differentiation;GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0032651 regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P58462-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35161-1", "uniprot_id": [ { "id": "CELR1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35161", "type": "external" } ], "mass": 330471.0, "length": 3034, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 1", "gene_name": "Celsr1", "organism": "Mouse", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 1 precursor", "refseq_ac": [ { "id": "NP_034016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034016", "type": "external" } ], "gene_names_uniprotkb": "Celsr1", "gene_names_refseq": "Adgrc1; Celsr1; Crsh; Scy; crash", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 1", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 1 precursor; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); seven-pass transmembrane receptor", "tax_id": 10090, "disease": "yellow nail syndrome (Disease Ontology:DOID:0050468); hereditary lymphedema (Disease Ontology:DOID:0050580)", "pathway": " (mmu:12614)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11850187;11891983;21183079;21750661;28011936;30016717;34418053;9339365;9858697", "class_list": "", "function": "Developmental expression profiles of Celsr (Flamingo) genes in the mouse, [RefSeq, PubMed]; Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development, [RefSeq, PubMed]; Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 13, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 30, "binding_glycan_count": 0, "secondary_ac_list": "E9QK27", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane", "go_biological_process": "GO:0097475 motor neuron migration;GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0007626 locomotory behavior;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O35161-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMW8-1", "uniprot_id": [ { "id": "CLN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMW8", "type": "external" } ], "mass": 39329.0, "length": 341, "protein_name": "Bis(monoacylglycero)phosphate synthase CLN5", "gene_name": "Cln5", "organism": "Mouse", "refseq_name": "bis(monoacylglycero)phosphate synthase CLN5 precursor", "refseq_ac": [ { "id": "NP_001028414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028414", "type": "external" } ], "gene_names_uniprotkb": "Cln5; Bmps", "gene_names_refseq": "A730075N08Rik; Cln5", "protein_names_uniprotkb": "Bis(monoacylglycero)phosphate synthase CLN5; 2.3.1.-; 3.1.2.22; BMP synthase CLN5; Ceroid-lipofuscinosis neuronal protein 5; Palmitoyl protein thioesterase CLN5; Protein CLN5; S-depalmitoylase CLN5", "protein_names_refseq": "BMP synthase CLN5; S-depalmitoylase CLN5; bis(monoacylglycero)phosphate synthase CLN5 precursor; bis(monoacylglycero)phosphate synthase CLN5; ceroid-lipofuscinosis neuronal protein 5 homolog; palmitoyl protein thioesterase CLN5", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 5 (Disease Ontology:DOID:0110728)", "pathway": " (mmu:211286)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15207259;18371231;19941651;20052765;21750661;26342652;29514215;30899004;31219806;31294445;35427157", "class_list": "", "function": "Because the role of the functionally uncharacterized Cln5 protein remains unclear these studies may offer clues to the unraveling of its possible function(s) Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane., [UniProtKB, UniProtKB]; Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation., [UniProtKB, PubMed]; Mouse Cln5 is a soluble lysosomal glycoprotein expressed throughout embryonic brain, increasing during development; prominent expression is observed in cerebellar Purkinje cells, cerebral neurons, hippocampal pyramidal cells, and hippocampal interneurons., [RefSeq, PubMed]; Quantification revealed that the amounts of 12 different soluble lysosomal proteins were significantly reduced in Cln7 ko MEFs compared with wild-type controls. One of the most significantly depleted lysosomal proteins was Cln5 protein that underlies another distinct neuronal ceroid lipofuscinosis disorder, [RefSeq, PubMed]; Results show that loss of CLN5 triggers alterations in development and defects in embryonic interneurons. This may occur through increased binding of REST to Gad1. The study presents evidence that CLN5 functions as a critical modulator of key parameters required for proper neuronal development and maturation, and that the neurodegenerative processes of CLN5 disease pathophysiology have a neurodevelopmental component., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8C054;Q8R152", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0160121 bis(monoacylglycero)phosphate synthase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007420 brain development;GO:0007601 visual perception;GO:0007040 lysosome organization;GO:0042147 retrograde transport, endosome to Golgi;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3UMW8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2W9-1", "uniprot_id": [ { "id": "CN093_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2W9", "type": "external" } ], "mass": 58780.0, "length": 541, "protein_name": "Uncharacterized protein C14orf93 homolog", "gene_name": "4931414P19Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C14orf93 homolog precursor", "refseq_ac": [ { "id": "NP_083166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083166", "type": "external" } ], "gene_names_uniprotkb": "4931414P19Rik", "gene_names_refseq": "4931414P19Rik; Rtfc", "protein_names_uniprotkb": "Uncharacterized protein C14orf93 homolog", "protein_names_refseq": "uncharacterized protein C14orf93 homolog precursor; uncharacterized protein C14orf93 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74359)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;28230092;34428180", "class_list": "", "function": "Rtfc (4931414P19Rik) regulates in vitro thyroid differentiation and in vivo thyroid function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K2W9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI96-1", "uniprot_id": [ { "id": "CLIP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI96", "type": "external" } ], "mass": 75789.0, "length": 704, "protein_name": "CAP-Gly domain-containing linker protein 4", "gene_name": "Clip4", "organism": "Mouse", "refseq_name": "CAP-Gly domain-containing linker protein 4 isoform 1", "refseq_ac": [ { "id": "NP_084455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084455", "type": "external" } ], "gene_names_uniprotkb": "Clip4; Rsnl2", "gene_names_refseq": "1700024K14Rik; 1700074B05Rik; 4833417L20Rik; 5830409B12Rik; Clip4; Rsnl2", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 4; Restin-like protein 2", "protein_names_refseq": "CAP-Gly domain-containing linker protein 4 isoform 1; CAP-Gly domain-containing linker protein 4; restin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78785)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW09;Q921Q4;Q9D2S6", "ec_number_list": [], "go_molecular_function": "GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CI96-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPU4-1", "uniprot_id": [ { "id": "CPSF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPU4", "type": "external" } ], "mass": 160818.0, "length": 1441, "protein_name": "Cleavage and polyadenylation specificity factor subunit 1", "gene_name": "Cpsf1", "organism": "Mouse", "refseq_name": "cleavage and polyadenylation specificity factor subunit 1 isoform 1", "refseq_ac": [ { "id": "NP_001157645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157645", "type": "external" } ], "gene_names_uniprotkb": "Cpsf1; Cpsf160", "gene_names_refseq": "CPSF160; Cpsf1", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; Cleavage and polyadenylation specificity factor 160 kDa subunit", "protein_names_refseq": "CPSF 160 kDa subunit; cleavage and polyadenylation specificity factor 160 kDa subunit; cleavage and polyadenylation specificity factor subunit 1 isoform 1; cleavage and polyadenylation specificity factor subunit 1", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:94230); (R-MMU-159231); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11369601;17927953;21183079;21750661;25428506;30084848;31219806;31599954;34428180;34887587;40885482", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003676 nucleic acid binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9EPU4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AM05-1", "uniprot_id": [ { "id": "CNTLN_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AM05", "type": "external" } ], "mass": 160747.0, "length": 1397, "protein_name": "Centlein", "gene_name": "Cntln", "organism": "Mouse", "refseq_name": "centlein isoform 1", "refseq_ac": [ { "id": "NP_780484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780484", "type": "external" } ], "gene_names_uniprotkb": "Cntln", "gene_names_refseq": "B430108F07Rik; Cntln; D530005L17Rik", "protein_names_uniprotkb": "Centlein; Centrosomal protein", "protein_names_refseq": "centlein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:338349)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19131326;21183079;21913724;22872234;26915804;31219806;34203471;34428180;35820727;36210013;37475549", "class_list": "", "function": "A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation., [RefSeq, PubMed]; Required for centrosome cohesion and recruitment of CEP68 to centrosomes., [UniProtKB, UniProtKB]; Taken together, we propose that centlein is involved in MT stability and neuritogenesis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0PJC6;Q3TNP8;Q5EBN8;Q8C748;Q8C9U3;Q8CD25;Q8CE32;Q8R2F0;Q8R2P3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0032880 regulation of protein localization;GO:0008104 intracellular protein localization;GO:0010457 centriole-centriole cohesion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A2AM05-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3P7-1", "uniprot_id": [ { "id": "CLUA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3P7", "type": "external" } ], "mass": 47953.0, "length": 413, "protein_name": "Clusterin-associated protein 1", "gene_name": "Cluap1", "organism": "Mouse", "refseq_name": "clusterin-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_084014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084014", "type": "external" } ], "gene_names_uniprotkb": "Cluap1", "gene_names_refseq": "2310030D15Rik; 2610111M03Rik; Cluap1", "protein_names_uniprotkb": "Clusterin-associated protein 1", "protein_names_refseq": "clusterin-associated protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76779); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17242355;20173027;21183079;21750661;23351563;23742838;26980730;31219806;34428180", "class_list": "", "function": "A ciliogenesis defect of Cluap1-deficient embryonic fibroblasts was rescued by exogenous expression of wild-type Cluap1 but not by mutant Cluap1 lacking the binding ability to other IFT-B components, [RefSeq, PubMed]; Cluap1 contributes to ciliogenesis by regulating the intraflagellar transport cycle at the base and tip of the cilium, [RefSeq, PubMed]; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3Y8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0015629 actin cytoskeleton;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0021508 floor plate formation;GO:0001843 neural tube closure;GO:0060271 cilium assembly;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R3P7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FD5-1", "uniprot_id": [ { "id": "CLH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FD5", "type": "external" } ], "mass": 191557.0, "length": 1675, "protein_name": "Clathrin heavy chain 1", "gene_name": "Cltc", "organism": "Mouse", "refseq_name": "clathrin heavy chain 1 isoform 2", "refseq_ac": [ { "id": "NP_001003908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003908", "type": "external" } ], "gene_names_uniprotkb": "Cltc", "gene_names_refseq": "3110065L21Rik; CHC; Cltc", "protein_names_uniprotkb": "Clathrin heavy chain 1", "protein_names_refseq": "clathrin heavy chain 1 isoform 2; clathrin heavy chain 1; clathrin, heavy polypeptide (Hc)", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 56 (Disease Ontology:DOID:0080226)", "pathway": " (mmu:67300); (R-MMU-177504); (R-MMU-190873); (R-MMU-196025); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722); (R-MMU-437239); (R-MMU-5099900); (R-MMU-5140745); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8866427); (R-MMU-8964038); (R-MMU-9013420); (R-MMU-9013424)", "pathway_count": 16, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;16479539;18034455;19224205;20133602;20173027;21183079;21750661;22872234;23806337;25428506;25605945;26740625;26756164;28011936;29187734;30084848;30779550;31219806;32152506;33300544;34203471;34428180;34865123;34887587;35820727;36210013;36288343;37453647;37507081;37828378;39627609;39927985", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0031072 heat shock protein binding;GO:0005198 structural molecule activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030118 clathrin coat;GO:0098835 presynaptic endocytic zone membrane;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006886 intracellular protein transport;GO:0031623 receptor internalization;GO:0051301 cell division;GO:0090307 mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q68FD5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12960-1", "uniprot_id": [ { "id": "CNTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P12960", "type": "external" } ], "mass": 113388.0, "length": 1020, "protein_name": "Contactin-1", "gene_name": "Cntn1", "organism": "Mouse", "refseq_name": "contactin-1 precursor", "refseq_ac": [ { "id": "NP_001153119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153119", "type": "external" } ], "gene_names_uniprotkb": "Cntn1", "gene_names_refseq": "CNTN; Cntn1; F3cam; usl", "protein_names_uniprotkb": "Contactin-1; Neural cell surface protein F3", "protein_names_refseq": "contactin-1 precursor; neural cell surface protein F3", "tax_id": 10090, "disease": "Compton-North congenital myopathy (Disease Ontology:DOID:0080101)", "pathway": " (mmu:12805)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11395001;11564762;14567914;20133774;2474555;28657654;30899004;31112734;33300544;35820727;35822049;37014368;40885482;7678967", "class_list": "", "function": "CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice., [RefSeq, PubMed]; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 7, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 33, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXV7;Q8BR42;Q8C6A0", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0007219 Notch signaling pathway;GO:0007626 locomotory behavior;GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "P12960-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMK4-1", "uniprot_id": [ { "id": "CKAP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMK4", "type": "external" } ], "mass": 63692.0, "length": 575, "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "Ckap4", "organism": "Mouse", "refseq_name": "cytoskeleton-associated protein 4", "refseq_ac": [ { "id": "NP_780660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780660", "type": "external" } ], "gene_names_uniprotkb": "Ckap4", "gene_names_refseq": "5630400A09Rik; CLIMP-63; Ckap4; P63", "protein_names_uniprotkb": "Cytoskeleton-associated protein 4; 63-kDa cytoskeleton-linking membrane protein; Climp-63; p63", "protein_names_refseq": "63 kDa membrane protein; 63-kDa cytoskeleton-linking membrane protein; cytoskeleton-associated protein 4", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:216197); (R-MMU-381426); (R-MMU-5683826); (R-MMU-6798695); (R-MMU-8957275); (R-MMU-9696264); (R-MMU-9696270)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "16556726;21183079;23108156;23806337;24788674;25153642;27562070;28528544;32075961;34428180;34887587;35108641", "class_list": "", "function": "CKAP4 contributes to the progression of vascular calcification (VC) in chronic kidney disease (CKD) by modulating YAP phosphorylation and MMP2 expression., [RefSeq, PubMed]; CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules., [RefSeq, PubMed]; High-affinity epithelial cell surface receptor for APF., [UniProtKB]; Mediates the anchoring of the endoplasmic reticulum to microtubules., [UniProtKB]; P63 positively regulates desmosome adhesion by directly controlling the expression of several desmosome genes, including Dsp, Dsc3 and Dsg1., [RefSeq, PubMed]; Thus p63 closely interacts with SP-A and may play a role in the trafficking or the biological function of the surfactant protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRB4;Q8BTK8;Q8R3F2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BMK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXX4-1", "uniprot_id": [ { "id": "S2513_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXX4", "type": "external" } ], "mass": 74467.0, "length": 676, "protein_name": "Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial", "gene_name": "Slc25a13", "organism": "Mouse", "refseq_name": "electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001171043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171043", "type": "external" } ], "gene_names_uniprotkb": "Slc25a13; Agc2", "gene_names_refseq": "Ctrn; Slc25a13", "protein_names_uniprotkb": "Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial; Citrin; Solute carrier family 25 member 13", "protein_names_refseq": "calcium-binding mitochondrial carrier protein Aralar2; citrin; electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial isoform 2; electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial; mitochondrial aspartate glutamate carrier 2; solute carrier family 25, member 13", "tax_id": 10090, "disease": "neonatal-onset type II citrullinemia (Disease Ontology:DOID:0070341); adult-onset type II citrullinemia (Disease Ontology:DOID:0070342); intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (mmu:50799); (R-MMU-8963693); (R-MMU-9856872)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10610724;12084073;23576753;23806337;25428506;30084848;31219806;33300544;34428180;35820727;36210013;37453647;37507081;39927985", "class_list": "", "function": "Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development(CITRIN), [RefSeq, PubMed]; Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZF6;Q9DCF5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015172 acidic amino acid transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051592 response to calcium ion;GO:0006754 ATP biosynthetic process;GO:0006094 gluconeogenesis;GO:0045333 cellular respiration;GO:0015810 aspartate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QXX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Y7W8-1", "uniprot_id": [ { "id": "GGYF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "type": "external" } ], "mass": 149193.0, "length": 1291, "protein_name": "GRB10-interacting GYF protein 2", "gene_name": "Gigyf2", "organism": "Mouse", "refseq_name": "GRB10-interacting GYF protein 2 isoform b", "refseq_ac": [ { "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682", "type": "external" } ], "gene_names_uniprotkb": "Gigyf2; Kiaa0642; Perq2; Tnrc15", "gene_names_refseq": "2610016F01Rik; A830080H02Rik; Gigyf2; Tnrc15; mKIAA0642", "protein_names_uniprotkb": "GRB10-interacting GYF protein 2; PERQ amino acid-rich with GYF domain-containing protein 2; Trinucleotide repeat-containing gene 15 protein", "protein_names_refseq": "GRB10-interacting GYF protein 2 isoform b; PERQ amino acid-rich with GYF domain-containing protein 2; trinucleotide repeat containing 15", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:227331)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12771153;19144319;19744960;21183079;21750661;22645316;24129315;26763119;31219806;31599954;32782141;34428180;34887587;35822049;36852467;37517320;40885482", "class_list": "", "function": "Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function., [RefSeq, PubMed]; Identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling, [RefSeq, PubMed]; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:26763119). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:26763119). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF1 signaling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGQ7;Q3UNS2;Q63ZU9;Q80TV1;Q8K0R0;Q8R0A3", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0060090 molecular adaptor activity;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0008344 adult locomotory behavior;GO:0050881 musculoskeletal movement;GO:0050885 neuromuscular process controlling balance;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6Y7W8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3I9-1", "uniprot_id": [ { "id": "GLCI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3I9", "type": "external" } ], "mass": 57479.0, "length": 537, "protein_name": "Glucocorticoid-induced transcript 1 protein", "gene_name": "Glcci1", "organism": "Mouse", "refseq_name": "glucocorticoid-induced transcript 1 protein isoform 2", "refseq_ac": [ { "id": "NP_001273657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273657", "type": "external" } ], "gene_names_uniprotkb": "Glcci1; Gig18; Tssn1", "gene_names_refseq": "2310047L21Rik; A130036A18Rik; Fam117c; Gig18; Glcci1; Tssn1", "protein_names_uniprotkb": "Glucocorticoid-induced transcript 1 protein; Glucocorticoid-induced gene 18 protein; Testhymin; Thymocyte/spermatocyte selection protein 1", "protein_names_refseq": "glucocorticoid-induced gene 18 protein; glucocorticoid-induced transcript 1 protein isoform 2; glucocorticoid-induced transcript 1 protein; testhymin; thymocyte/spermatocyte selection protein 1", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:170772)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12557054;15345747;17114649;21183079;21750661;21952136;30084848;33895479;34050597", "class_list": "", "function": "GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B., [RefSeq, PubMed]; Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-beta1 signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80YT1;Q8CEA5;Q925C1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098846 podocyte foot", "go_biological_process": "GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K3I9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07802-1", "uniprot_id": [ { "id": "COE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07802", "type": "external" } ], "mass": 64464.0, "length": 591, "protein_name": "Transcription factor COE1", "gene_name": "Ebf1", "organism": "Mouse", "refseq_name": "transcription factor COE1 isoform 2", "refseq_ac": [ { "id": "NP_031923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031923", "type": "external" } ], "gene_names_uniprotkb": "Ebf1; Coe1; Ebf", "gene_names_refseq": "Ebf1; Ebf; O/E-1; OE-1; Olf-1; Olf1", "protein_names_uniprotkb": "Transcription factor COE1; Early B-cell factor; O/E-1; OE-1", "protein_names_refseq": "early B-cell factor; transcription factor COE1 isoform 2; transcription factor COE1", "tax_id": 10090, "disease": "lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (mmu:13591)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1915300;20451411;20876732;21750661;23812095;29187734;32130892;34428180;7542362;8491377;8497258;9151732", "class_list": "", "function": "Key pioneer transcription factor of B-cell specification and commitment (PubMed:1915300, PubMed:23812095, PubMed:7542362). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (PubMed:20876732). Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates (PubMed:20451411, PubMed:23812095). For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage (PubMed:20451411, PubMed:23812095). In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (PubMed:32130892)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q07802-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XI3-1", "uniprot_id": [ { "id": "IF4G3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XI3", "type": "external" } ], "mass": 174890.0, "length": 1579, "protein_name": "Eukaryotic translation initiation factor 4 gamma 3", "gene_name": "Eif4g3", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4 gamma 3 isoform 1", "refseq_ac": [ { "id": "NP_766291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766291", "type": "external" } ], "gene_names_uniprotkb": "Eif4g3", "gene_names_refseq": "1500002J22Rik; 4930523M17Rik; Eif4g3; G1-419-52; Gm32394; eIF4GII; repro8", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4 gamma 3; eIF-4-gamma 3; eIF-4-gamma II; eIF-4G 3; eIF4G 3; eIF4GII", "protein_names_refseq": "eIF-4-gamma 3; eIF-4-gamma II; eukaryotic translation initiation factor 4 gamma 3 isoform 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:230861); (R-MMU-1169408)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16452087;17242355;19144319;21183079;21750661;24129315;31219806;35820727;35822049;35951695", "class_list": "", "function": "Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:35951695). Functional homolog of EIF4G1 (PubMed:35951695)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6GQV5;Q80Y69;Q8BJ68;Q8BQF3;Q8C6Q3;Q8CIH0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0006413 translational initiation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80XI3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM58-1", "uniprot_id": [ { "id": "CRLF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM58", "type": "external" } ], "mass": 46662.0, "length": 425, "protein_name": "Cytokine receptor-like factor 1", "gene_name": "Crlf1", "organism": "Mouse", "refseq_name": "cytokine receptor-like factor 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_061297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061297", "type": "external" } ], "gene_names_uniprotkb": "Crlf1; Crlm3", "gene_names_refseq": "CLF-1; CRLM-3; CRLM3; Crlf1; NR6.1; NR6", "protein_names_uniprotkb": "Cytokine receptor-like factor 1; CLF-1; CRLM-3; Cytokine receptor-like molecule 3; Cytokine-like factor 1; NR6; Novel cytokine receptor 6", "protein_names_refseq": "cytokine receptor-like factor 1 isoform 2 precursor; cytokine receptor-like molecule 3; cytokine-like factor 1; novel cytokine receptor 6", "tax_id": 10090, "disease": "cold-induced sweating syndrome 1 (Disease Ontology:DOID:0080329)", "pathway": " (mmu:12931); (R-MMU-6788467); (R-MMU-9020956)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10359701;15378723;21750661;25428506;34428180;34551709;37551555;37828378", "class_list": "", "function": "Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis via ERK1/2 signaling pathway., [RefSeq, PubMed]; Functions as secretory protein carrier chaperone that promotes cellular release. Also functions as a cytokine subunit within the CRLF1-CLCF1 heterodimer, which engages the CNTF receptor complex (CNTFR, IL6ST/gp130, LIFR). As part of the CRLF-CLCF1 complex, binds to CNTFR, induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Moreover, CLCF1/CLF heterodimer induces tyrosine phosphorylation of PTPN11, that associates with IL6ST/gp130-LIFR, which in turn recruits PIK3 protein kinase followed by AKT protein phosphorylation. Participates in the survival of embryonic motor neurons. May also play a regulatory role in the immune system., [UniProtKB, UniProtKB]; Suppression of CRLF1 promotes the chondrogenic differentiation of bone marrow-derived mesenchymal stem and protects cartilage tissue from damage in osteoarthritis via activation of miR-320. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the cytokine type I receptor family. The encoded protein functions as a cytokine receptor subunit and may be involved in immune system regulation and fetal development. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity;GO:0005127 ciliary neurotrophic factor receptor binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0097058 CRLF-CLCF1 complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043524 negative regulation of neuron apoptotic process;GO:0009306 protein secretion;GO:0001657 ureteric bud development;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JM58-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19783-1", "uniprot_id": [ { "id": "COX41_MOUSE", "url": "https://www.uniprot.org/uniprot/P19783", "type": "external" } ], "mass": 19530.0, "length": 169, "protein_name": "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial", "gene_name": "Cox4i1", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001280488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280488", "type": "external" } ], "gene_names_uniprotkb": "Cox4i1; Cox4a; Cox4; Coxiv", "gene_names_refseq": "COX IV-1; COXIV; COX; Cox4a; Cox4i1; Cox4; IV-1", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; COX IV-1; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1", "protein_names_refseq": "cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2; cytochrome c oxidase subunit IV; cytochrome c oxidase, subunit IVa", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 16 (Disease Ontology:DOID:0070501); protein-energy malnutrition (Disease Ontology:DOID:11801); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (mmu:12857); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;1654830;20959514;2173832;21750661;23576753;23806337;31219806;32973183;33300544;34428180;34616041;36288343;37195149;37453647;37507081;37828378;38575788;39927985", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q545A9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P19783-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QA28-1", "uniprot_id": [ { "id": "CEA16_MOUSE", "url": "https://www.uniprot.org/uniprot/E9QA28", "type": "external" } ], "mass": 46352.0, "length": 426, "protein_name": "Cell adhesion molecule CEACAM16", "gene_name": "Ceacam16", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM16 precursor", "refseq_ac": [ { "id": "NP_001028591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028591", "type": "external" } ], "gene_names_uniprotkb": "Ceacam16", "gene_names_refseq": "Ceacam16; Gm769", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM16; CEA cell adhesion molecule 16; Carcinoembryonic antigen-related cell adhesion molecule 16", "protein_names_refseq": "CEA-related cell adhesion molecule 16; carcinoembryonic antigen-related cell adhesion molecule 16; cell adhesion molecule CEACAM16 precursor; cell adhesion molecule CEACAM16", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); autosomal dominant nonsyndromic deafness 4B (Disease Ontology:DOID:0110574); autosomal recessive nonsyndromic deafness 113 (Disease Ontology:DOID:0111636)", "pathway": " (mmu:330483)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21368133;21750661;22544735;25080593;34555361", "class_list": "", "function": "Age-related degradation of tectorial membrane dynamics with loss of CEACAM16., [RefSeq, PubMed]; CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane, [RefSeq, PubMed]; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane., [UniProtKB, PubMed]; The data of this study indicated that CEACAM16 is required for striated-sheet matrix formation. Its continual expression may stabilize the noncollagenous TM matrix., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9552, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RUD6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032426 stereocilium tip", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E9QA28-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUB7-1", "uniprot_id": [ { "id": "CLCKA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUB7", "type": "external" } ], "mass": 75684.0, "length": 687, "protein_name": "Chloride channel protein ClC-Ka", "gene_name": "Clcnka", "organism": "Mouse", "refseq_name": "chloride channel protein ClC-Ka", "refseq_ac": [ { "id": "NP_001139779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139779", "type": "external" } ], "gene_names_uniprotkb": "Clcnka; Clcnk1", "gene_names_refseq": "CLC-K1; Clcnk1; Clcnka", "protein_names_uniprotkb": "Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1", "protein_names_refseq": "chloride channel K1; chloride channel Ka; chloride channel protein ClC-Ka; putative basolateral cTAL chloride channel ClC-Ka", "tax_id": 10090, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:12733); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11014860;11734858;21750661;23791703;25428506;29326302;30084848;34499620;9916798", "class_list": "", "function": "Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed:23791703). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:23791703). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA:BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials (PubMed:23791703). Mediates transepithelial chloride transport from the lumen to interstitial compartment along the thin ascending limb of Henle's loop, contributing to generation of hypertonic medullary interstitium as a countercurrent system to achieve urine concentration (PubMed:34499620, PubMed:9916798). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADB3;Q6UB69;Q8JZU7", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport;GO:0050878 regulation of body fluid levels;GO:0030321 transepithelial chloride transport;GO:0072053 renal inner medulla development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUB7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53996-1", "uniprot_id": [ { "id": "CNBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P53996", "type": "external" } ], "mass": 19592.0, "length": 178, "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "Cnbp", "organism": "Mouse", "refseq_name": "CCHC-type zinc finger nucleic acid binding protein isoform 2", "refseq_ac": [ { "id": "NP_001103215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103215", "type": "external" } ], "gene_names_uniprotkb": "Cnbp; Cnbp1; Znf9", "gene_names_refseq": "Cnbp1; Cnbp; Znf9", "protein_names_uniprotkb": "CCHC-type zinc finger nucleic acid binding protein; CNBP; Cellular nucleic acid-binding protein; Zinc finger protein 9", "protein_names_refseq": "CCHC-type zinc finger nucleic acid binding protein isoform 2; CCHC-type zinc finger nucleic acid binding protein; cellular nucleic acid binding protein 1; zinc finger protein 9", "tax_id": 10090, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759)", "pathway": " (mmu:12785)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12706888;21183079;21750661;23806337;24129315;35822049;37453647;38432502;7896269", "class_list": "", "function": "Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating beta-catenin signaling., [RefSeq, PubMed]; Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (PubMed:12706888). Binds single-stranded RNA in a sequence-specific manner (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y06;Q8BP23", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003727 single-stranded RNA binding;GO:0045182 translation regulator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53996-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00322-1", "uniprot_id": [ { "id": "CEBPD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00322", "type": "external" } ], "mass": 28631.0, "length": 268, "protein_name": "CCAAT/enhancer-binding protein delta", "gene_name": "Cebpd", "organism": "Mouse", "refseq_name": "CCAAT/enhancer-binding protein delta", "refseq_ac": [ { "id": "NP_031705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031705", "type": "external" } ], "gene_names_uniprotkb": "Cebpd; Crp3", "gene_names_refseq": "Cebpd; c/EBPdelta", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein delta; C/EBP delta; C/EBP-related protein 3", "protein_names_refseq": "C/EBP delta; CCAAT/enhancer binding protein (C/EBP), delta; CCAAT/enhancer-binding protein delta; c/EBP-related protein 3", "tax_id": 10090, "disease": "prolactinoma (Disease Ontology:DOID:5394)", "pathway": " (mmu:12609)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1840554;1884998;19641492;23993701;34428180;38419037;38762596;39082925;39273396;7594592", "class_list": "", "function": "C/EBPdelta Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner., [RefSeq, PubMed]; Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPdelta in Pancreatic Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD. Publication Status: Online-Only, [RefSeq, PubMed]; PPA1 promotes adipogenesis by regulating the stability of C/EBPs., [RefSeq, PubMed]; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:19641492, PubMed:7594592). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U937;Q8BW92", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q00322-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PZD9-1", "uniprot_id": [ { "id": "CEBPE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PZD9", "type": "external" } ], "mass": 30617.0, "length": 281, "protein_name": "CCAAT/enhancer-binding protein epsilon", "gene_name": "Cebpe", "organism": "Mouse", "refseq_name": "CCAAT/enhancer-binding protein epsilon", "refseq_ac": [ { "id": "NP_997014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997014", "type": "external" } ], "gene_names_uniprotkb": "Cebpe; Gm294", "gene_names_refseq": "C/EBPepsilon; C/EBPe; CRP1; Cebpe; Gm294", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein epsilon; C/EBP epsilon", "protein_names_refseq": "C/EBP-related protein 1; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer-binding protein epsilon", "tax_id": 10090, "disease": "immunodeficiency 108 (Disease Ontology:DOID:0061077)", "pathway": " (mmu:110794)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;25428506;30952671;34428180", "class_list": "", "function": "Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation., [UniProtKB, UniProtKB]; We have identified a novel enhancer crucial for regulating expression of Cebpe and required for normal granulocytic differentiation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32MW9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PZD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSG1-1", "uniprot_id": [ { "id": "CE120_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSG1", "type": "external" } ], "mass": 112579.0, "length": 988, "protein_name": "Centrosomal protein of 120 kDa", "gene_name": "Cep120", "organism": "Mouse", "refseq_name": "centrosomal protein of 120 kDa", "refseq_ac": [ { "id": "NP_848801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848801", "type": "external" } ], "gene_names_uniprotkb": "Cep120; Ccdc100", "gene_names_refseq": "A230075C01; Ccdc100; Cep120", "protein_names_uniprotkb": "Centrosomal protein of 120 kDa; Cep120; Coiled-coil domain-containing protein 100", "protein_names_refseq": "centrosomal protein of 120 kDa; coiled-coil domain-containing protein 100", "tax_id": 10090, "disease": "Joubert syndrome 31 (Disease Ontology:DOID:0080277); short-rib thoracic dysplasia 13 with or without polydactyly (Disease Ontology:DOID:0110093)", "pathway": " (mmu:225523)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17920017;20360068;20956381;21183079;25251415;32772081;34428180;38177914", "class_list": "", "function": "Cep120 is essential for kidney stromal progenitor cell growth and differentiation., [RefSeq, PubMed]; Cep120 is required for centriole assembly and that the observed defect in neuronal migration might derive from a defect in this process., [RefSeq, PubMed]; Exome sequencing links CEP120 mutation to maternally derived aneuploid conception risk., [RefSeq, PubMed]; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; The loss of Talpid3-binding centrosomal protein Cep120 results in failed centriole duplication and consequently ciliogenesis, which together underlie Cep120 mutant cerebellar hypoplasia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y93;Q80ZQ2;Q8BG01;Q8C580;Q8C8B6;Q8CAF2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:1904951 positive regulation of establishment of protein localization;GO:0008283 cell population proliferation;GO:0021987 cerebral cortex development;GO:0032880 regulation of protein localization;GO:0032886 regulation of microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TSG1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI22-1", "uniprot_id": [ { "id": "CE128_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI22", "type": "external" } ], "mass": 128503.0, "length": 1102, "protein_name": "Centrosomal protein 128", "gene_name": "Cep128", "organism": "Mouse", "refseq_name": "centrosomal protein 128", "refseq_ac": [ { "id": "NP_861536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861536", "type": "external" } ], "gene_names_uniprotkb": "Cep128; 4930534B04Rik", "gene_names_refseq": "4930534B04Rik; 5430424K18Rik; Cep128; E230024F20", "protein_names_uniprotkb": "Centrosomal protein 128; Centrosomal protein of 128 kDa; Cep128", "protein_names_refseq": "centrosomal protein 128; centrosomal protein of 128 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:75216)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;30623524;34428180;34887587;35296684", "class_list": "", "function": "Is involved in the negative regulation of ciliogenesis and plays a role in spermatogenesis (PubMed:35296684). Contributes to the regulation of the TGFB/BMP signaling pathway at the primary cilium, where it is required for ciliary localization of RAB11A, likely affecting the trafficking and regulation of TGFB/BMP pathway components (By similarity). Required, together with ODF2, for the formation of the subdistal appendage of the centriole (PubMed:30623524)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0031965 nuclear membrane;GO:0005814 centriole", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:1902018 negative regulation of cilium assembly;GO:0007283 spermatogenesis;GO:0008104 intracellular protein localization;GO:0044458 motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BI22-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5U8-1", "uniprot_id": [ { "id": "CNBD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5U8", "type": "external" } ], "mass": 77892.0, "length": 673, "protein_name": "Cyclic nucleotide-binding domain-containing protein 2", "gene_name": "Cnbd2", "organism": "Mouse", "refseq_name": "cyclic nucleotide-binding domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_081861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081861", "type": "external" } ], "gene_names_uniprotkb": "Cnbd2; 4921517L17Rik; Cris", "gene_names_refseq": "4921517L17Rik; 5430421B09Rik; Cnbd2; Cris", "protein_names_uniprotkb": "Cyclic nucleotide-binding domain-containing protein 2; Cyclic nucleotide receptor involved in sperm function", "protein_names_refseq": "cyclic nucleotide-binding domain-containing protein 2 isoform 1; cyclic nucleotide-binding domain-containing protein 2; cyclic nucleotide-receptor involved in sperm function", "tax_id": 10090, "disease": "", "pathway": " (mmu:70873)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24339785", "class_list": "", "function": "Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm (PubMed:24339785)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Our results suggest that CRIS interacts during spermiogenesis with Ca(2+)-regulated proteins that in mature sperm are involved in flagellar bending., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ATV2;Q8R083", "ec_number_list": [], "go_molecular_function": "GO:0030552 cAMP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D5U8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJN6-1", "uniprot_id": [ { "id": "CNBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJN6", "type": "external" } ], "mass": 9174.0, "length": 81, "protein_name": "Beta-catenin-interacting protein 1", "gene_name": "Ctnnbip1", "organism": "Mouse", "refseq_name": "beta-catenin-interacting protein 1", "refseq_ac": [ { "id": "NP_001135402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135402", "type": "external" } ], "gene_names_uniprotkb": "Ctnnbip1; Catnbip1; Icat", "gene_names_refseq": "1110008O09Rik; 2310001I19Rik; Catnbip1; Ctnnbip1; Icat", "protein_names_uniprotkb": "Beta-catenin-interacting protein 1; Inhibitor of beta-catenin and Tcf-4", "protein_names_refseq": "beta-catenin-interacting protein 1; inhibitor of beta-catenin and Tcf-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67087); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10898789;12036951;21183079;27521659;36181623;37479047", "class_list": "", "function": "Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice., [RefSeq, PubMed]; MiR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis, [RefSeq, PubMed]; MiR-342-5p targets CTNNBIP1 to promote enterovirus 71 replication., [RefSeq, PubMed]; Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin., [RefSeq, PubMed]; Prevents the interaction between CTNNB1 and TCF family members, and acts as a negative regulator of the Wnt signaling pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding;GO:0001223 transcription coactivator binding;GO:0070016 armadillo repeat domain binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045657 positive regulation of monocyte differentiation;GO:0009952 anterior/posterior pattern specification;GO:0031333 negative regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJN6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YT8-1", "uniprot_id": [ { "id": "TM63A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YT8", "type": "external" } ], "mass": 91860.0, "length": 804, "protein_name": "Mechanosensitive cation channel TMEM63A", "gene_name": "Tmem63a", "organism": "Mouse", "refseq_name": "mechanosensitive cation channel TMEM63A isoform 1", "refseq_ac": [ { "id": "NP_659043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659043", "type": "external" } ], "gene_names_uniprotkb": "Tmem63a; Kiaa0792", "gene_names_refseq": "Tmem63a; Tmem64a", "protein_names_uniprotkb": "Mechanosensitive cation channel TMEM63A; Transmembrane protein 63A", "protein_names_refseq": "CSC1-like protein 1; mechanosensitive cation channel TMEM63A isoform 1; mechanosensitive cation channel TMEM63A", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 19 (Disease Ontology:DOID:0070400); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:208795); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;18250455;21183079;21750661;25428506;26495903;27045885;29187734;30382938;32375046;34428180;35820727;35821338;37543036;38127458;38388853;39495104", "class_list": "", "function": "Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels., [RefSeq, PubMed]; Mechanosensitive Ion Channel TMEM63A Gangs Up with Local Macrophages to Modulate Chronic Post-amputation Pain., [RefSeq, PubMed]; Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (By similarity). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (PubMed:38388853). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (PubMed:27045885, PubMed:32375046)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; TMEM63 proteins may serve as an osmolarity sensitive ion channel for the osmoreception., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCS5;Q69ZZ1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0005227 calcium-activated cation channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:1990760 osmolarity-sensing monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0007040 lysosome organization;GO:0160069 surfactant secretion", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q91YT8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CG14-1", "uniprot_id": [ { "id": "DERPC_MOUSE", "url": "https://www.uniprot.org/uniprot/P0CG14", "type": "external" } ], "mass": 52244.0, "length": 533, "protein_name": "Decreased expression in renal and prostate cancer protein", "gene_name": "Derpc", "organism": "Mouse", "refseq_name": "chromosome transmission fidelity protein 8 homolog", "refseq_ac": [ { "id": "NP_663387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663387", "type": "external" } ], "gene_names_uniprotkb": "Derpc", "gene_names_refseq": "5830457O10Rik; Chtf8; Ctf8; Derpc", "protein_names_uniprotkb": "Decreased expression in renal and prostate cancer protein", "protein_names_refseq": "CTF8, chromosome transmission fidelity factor 8 homolog; chromosome transmission fidelity factor 8; chromosome transmission fidelity protein 8 homolog; protein DERPC", "tax_id": 10090, "disease": "", "pathway": " (mmu:116621581); (mmu:214987)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22517741;22645316;24129315;25605945;31219806;32782141;32848054;34428180;35822049;36852467", "class_list": "", "function": "Potential tumor suppressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P0C6T0;Q8BHM2;Q8R5A5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P0CG14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50462-1", "uniprot_id": [ { "id": "CSRP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P50462", "type": "external" } ], "mass": 20895.0, "length": 194, "protein_name": "Cysteine and glycine-rich protein 3", "gene_name": "Csrp3", "organism": "Mouse", "refseq_name": "cysteine and glycine-rich protein 3", "refseq_ac": [ { "id": "NP_001185770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185770", "type": "external" } ], "gene_names_uniprotkb": "Csrp3; Clp; Mlp", "gene_names_refseq": "CRP3; Csrp3; MLP; MMLP", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 3; CRP3; Cysteine-rich protein 3; LIM domain protein, cardiac; Muscle LIM protein", "protein_names_refseq": "LIM domain protein, cardiac; cardiac LIM protein; cysteine and glycine-rich protein 3; cysteine-rich protein 3; muscle LIM protein", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 12 (Disease Ontology:DOID:0110318); dilated cardiomyopathy 1M (Disease Ontology:DOID:0110449); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:13009)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15665106;18258855;20044516;21183079;21750661;22645316;27353086;36288343;37507081;39927985;8773898;9039266", "class_list": "", "function": "Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (PubMed:15665106, PubMed:9039266). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (By similarity). In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (PubMed:27353086)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0035995 detection of muscle stretch;GO:0072594 establishment of protein localization to organelle;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P50462-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640M6-1", "uniprot_id": [ { "id": "GDE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640M6", "type": "external" } ], "mass": 68890.0, "length": 607, "protein_name": "Glycerophosphodiester phosphodiesterase 2", "gene_name": "Gdpd5", "organism": "Mouse", "refseq_name": "glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 1", "refseq_ac": [ { "id": "NP_958740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958740", "type": "external" } ], "gene_names_uniprotkb": "Gdpd5; Gde2", "gene_names_refseq": "Gde2; Gdpd5", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 2; 3.1.4.-; 3.1.4.2; Glycerophosphocholine phosphodiesterase GDPD5; Glycerophosphodiester phosphodiesterase domain-containing protein 5", "protein_names_refseq": "glycerophosphocholine phosphodiesterase GDPD5; glycerophosphodiester phosphodiesterase 2; glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 1; glycerophosphodiester phosphodiesterase domain-containing protein 5; phosphoinositide phospholipase C GDPD5", "tax_id": 10090, "disease": "", "pathway": " (mmu:233552)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15276213;17275818;18667693;19766572;21750661;21943603;33731436;38575965", "class_list": "", "function": "Data suggest that neuronal GDE2 controls motor neuron subtype diversity through a non-cell-autonomous feedback mechanism that directly regulates progenitor cell differentiation., [RefSeq, PubMed]; Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of various proteins, releasing them from the plasma membrane into the extracellular space. Cleaves the GPI-anchor of glypican-6/GPC6, thereby positively regulating neuron differentiation in a cell-autonomous manner. May also hydrolyze the GPI-anchor of glypican-3/GPC3. Cleaves the GPI-anchor of the serine protease inhibitor RECK, leading to its inactivation (PubMed:33731436). RECK inactivation inhibits NOTCH signaling in neighboring cells and induces differentiation of spinal motor neurons (Probable). RECK inactivation can also regulate amyloid-beta precursor protein (APP) processing by ADAM10 (PubMed:33731436). May additionally catalyze the hydrolysis of the phosphodiester bond in sn-glycerol 3-phosphocholine, potentially contributing to osmotic regulation of cellular glycerophosphocholine levels (PubMed:18667693)., [UniProtKB, PubMed, PubMed, PubMed]; GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte glycerophosphocholine., [RefSeq, PubMed]; Loss of GDE2 leads to complex behavioral changes including memory impairment. Publication Status: Online-Only, [RefSeq, PubMed]; Study identified the antioxidant enzyme Prdx1 as an interactor of GDE2 and uncover a developmental role for Prdx1 in regulating neuronal differentiation in the spinal cord., [RefSeq, PubMed]; These results demonstrate that GDE2 expression during neuronal differentiation plays an important role for growing neurites., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0T5;Q8R3N5", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.2", "type": "external" }, { "id": "3.1.4.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.43", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0047389 glycerophosphocholine phosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0031175 neuron projection development;GO:0045666 positive regulation of neuron differentiation;GO:0021522 spinal cord motor neuron differentiation;GO:0045787 positive regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q640M6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0X8-1", "uniprot_id": [ { "id": "FEZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0X8", "type": "external" } ], "mass": 45215.0, "length": 392, "protein_name": "Fasciculation and elongation protein zeta-1", "gene_name": "Fez1", "organism": "Mouse", "refseq_name": "fasciculation and elongation protein zeta-1 isoform 1", "refseq_ac": [ { "id": "NP_898994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898994", "type": "external" } ], "gene_names_uniprotkb": "Fez1", "gene_names_refseq": "Fez1; UNC-76; UNC76", "protein_names_uniprotkb": "Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1", "protein_names_refseq": "fasciculation and elongation protein zeta-1 isoform 1; zygin I; zygin-1", "tax_id": 10090, "disease": "Jacobsen Syndrome (Disease Ontology:DOID:0111723); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:235180)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;15579145;18647754;21183079;21750661;24726361;27247180;28928414", "class_list": "", "function": "Dendrite growth depends on degradation of FEZ1 regulated by Cdc20/APC., [RefSeq, PubMed]; Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex., [RefSeq, PubMed]; Investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1, [RefSeq, PubMed]; Loss of HDAC11 had no obvious impact on brain morphology and neural stem/precursor cells isolated from Hdac11 (KO/KO) mice had comparable proliferation and differentiation characteristics. However, in differentiating neural cells this study observed decreased expression of schizophrenia-associated gene Fez1. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity)., [UniProtKB]; Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3YE74", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0010976 positive regulation of neuron projection development;GO:0021766 hippocampus development;GO:0071363 cellular response to growth factor stimulus;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K0X8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499D0-1", "uniprot_id": [ { "id": "FOXN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q499D0", "type": "external" } ], "mass": 50345.0, "length": 457, "protein_name": "Forkhead box protein N3", "gene_name": "Foxn3", "organism": "Mouse", "refseq_name": "forkhead box protein N3", "refseq_ac": [ { "id": "NP_899009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899009", "type": "external" } ], "gene_names_uniprotkb": "Foxn3; Ches1", "gene_names_refseq": "5430426H20Rik; Ches1l; Ches1; Foxn3; HTLFL1", "protein_names_uniprotkb": "Forkhead box protein N3; Checkpoint suppressor 1", "protein_names_refseq": "checkpoint suppressor 1; forkhead box protein N3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71375)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;29996093;34919141;35820727", "class_list": "", "function": "Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity)., [UniProtKB, UniProtKB]; Liver FOXN3 and glucagon control fasting glucose., [RefSeq, PubMed]; Regulation of retinal amacrine cell generation by miR-216b and Foxn3., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5N8;Q9CU83", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q499D0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35583-1", "uniprot_id": [ { "id": "FOXA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P35583", "type": "external" } ], "mass": 48498.0, "length": 459, "protein_name": "Hepatocyte nuclear factor 3-beta", "gene_name": "Foxa2", "organism": "Mouse", "refseq_name": "hepatocyte nuclear factor 3-beta isoform a", "refseq_ac": [ { "id": "NP_001277994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277994", "type": "external" } ], "gene_names_uniprotkb": "Foxa2; Hnf3b; Tcf-3b; Tcf3b", "gene_names_refseq": "Foxa2; HNF3-beta; HNF3beta; Hnf-3b; Hnf3b; Tcf-3b; Tcf3b", "protein_names_uniprotkb": "Hepatocyte nuclear factor 3-beta; Forkhead box protein A2; HNF-3-beta; HNF-3B", "protein_names_refseq": "HNF-3-beta; forkhead box protein A2; hepatocyte nuclear factor 3 beta (winged helix transcription factor); hepatocyte nuclear factor 3-beta isoform a; hepatocyte nuclear factor 3-beta", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:15376)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11445544;11875061;14500912;15616563;15668254;15959514;16740652;17242355;17596284;18336786;19141476;19436110;21183079;21750661;30084848;32034274;8034310;8069909;8306889;8375339", "class_list": "", "function": "Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; Foxa1 and Foxa2 seem to have at least in part redundant roles. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors; inhibits AR-mediated transcription from the LCN5 promoter. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. In pancreatic beta cells activates transcription of potassium channel subunits KCNJ11 and ABCC8. Involved in regulation of fat metabolism; activates transcriptional programs of lipid metabolism and ketogenesis at low insulin state. Involved in transcriptional regulation of MUC2 in the intestine., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR89;Q60602", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030054 cell junction;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P35583-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63137-1", "uniprot_id": [ { "id": "GBRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P63137", "type": "external" } ], "mass": 59197.0, "length": 512, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-2", "gene_name": "Gabrb2", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001334243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334243", "type": "external" } ], "gene_names_uniprotkb": "Gabrb2; Gabrb-2", "gene_names_refseq": "C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2; Gabrb2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2; GABAAR subunit beta-2", "protein_names_refseq": "GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; gamma-aminobutyric acid (GABA) A receptor, subunit beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; gamma-aminobutyric acid receptor beta-2 subunit; gamma-aminobutyric acid receptor subunit beta-2 isoform 1 precursor; gamma-aminobutyric acid receptor subunit beta-2", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); developmental and epileptic encephalopathy 92 (Disease Ontology:DOID:0080471); autistic disorder (Disease Ontology:DOID:12849); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:14401); (R-MMU-977443)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18034455;19763268;27129275;30899004;33109704;33300544;36287173;7893750", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6H6R7;D1LYT3;P15432", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060384 innervation;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0060119 inner ear receptor cell development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P63137-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61169-1", "uniprot_id": [ { "id": "GATA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61169", "type": "external" } ], "mass": 59307.0, "length": 589, "protein_name": "Transcription factor GATA-6", "gene_name": "Gata6", "organism": "Mouse", "refseq_name": "transcription factor GATA-6", "refseq_ac": [ { "id": "NP_034388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034388", "type": "external" } ], "gene_names_uniprotkb": "Gata6", "gene_names_refseq": "GATA-6; Gata6", "protein_names_uniprotkb": "Transcription factor GATA-6; GATA-binding factor 6", "protein_names_refseq": "GATA-binding factor 6; transcription factor GATA-6", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); atrial heart septal defect 9 (Disease Ontology:DOID:0110114); pancreatic hypoplasia-diabetes-congenital heart disease syndrome (Disease Ontology:DOID:0111733); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); Klatskin's tumor (Disease Ontology:DOID:4927); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:14465); (R-MMU-5683826); (R-MMU-983231)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10608869;15329343;16199866;19666519;21750661;25428506;25969542;40997131;8660897;8812463", "class_list": "glycogene", "function": "Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). May regulate genes that protect epithelial cells from bacterial infection (By similarity). Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97729;Q3UQJ2;Q9QZK3", "ec_number_list": [], "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002759 regulation of antimicrobial humoral response;GO:0098773 skin epidermis development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61169-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY14-1", "uniprot_id": [ { "id": "FOXE3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY14", "type": "external" } ], "mass": 30541.0, "length": 288, "protein_name": "Forkhead box protein E3", "gene_name": "Foxe3", "organism": "Mouse", "refseq_name": "forkhead box protein E3", "refseq_ac": [ { "id": "NP_056573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056573", "type": "external" } ], "gene_names_uniprotkb": "Foxe3", "gene_names_refseq": "FREAC8; Foxe3; dyl; rct", "protein_names_uniprotkb": "Forkhead box protein E3", "protein_names_refseq": "Rinshoken cataract; dysgenetic lens; forkhead box protein E3", "tax_id": 10090, "disease": "anterior segment dysgenesis (Disease Ontology:DOID:0060648); anterior segment dysgenesis 2 (Disease Ontology:DOID:0080607); cataract 34 multiple types (Disease Ontology:DOID:0110230); congenital aphakia (Disease Ontology:DOID:11367); thoracic aortic aneurysm (Disease Ontology:DOID:14004)", "pathway": " (mmu:30923)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10652278;10890982;11980846;16199865;17064680;25428506;26854927;27218149", "class_list": "", "function": "Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278). Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002930 trabecular meshwork development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QY14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1S8-1", "uniprot_id": [ { "id": "GAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1S8", "type": "external" } ], "mass": 73208.0, "length": 665, "protein_name": "GRB2-associated-binding protein 2", "gene_name": "Gab2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gab2", "gene_names_refseq": "", "protein_names_uniprotkb": "GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; PH domain-containing adaptor molecule p97", "protein_names_refseq": "", "tax_id": 10090, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (R-MMU-109704); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-2730905); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-912526); (R-MMU-9607240); (R-MMU-9674555)", "pathway_count": 9, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10068651;11449275;11572860;15750601;16456001;17374739;17947660;19172738;21183079;23478294;30084848;9885561", "class_list": "", "function": "Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling (PubMed:15750601). In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1X3", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019904 protein domain specific binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0019903 protein phosphatase binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z1S8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1E4-1", "uniprot_id": [ { "id": "GYS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1E4", "type": "external" } ], "mass": 83927.0, "length": 738, "protein_name": "Glycogen [starch] synthase, muscle", "gene_name": "Gys1", "organism": "Mouse", "refseq_name": "glycogen [starch] synthase, muscle", "refseq_ac": [ { "id": "NP_109603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109603", "type": "external" } ], "gene_names_uniprotkb": "Gys1; Gys3; Gys", "gene_names_refseq": "Gys1; Gys3; MGS", "protein_names_uniprotkb": "Glycogen [starch] synthase, muscle; 2.4.1.11; Glycogen synthase 1", "protein_names_refseq": "glycogen [starch] synthase, muscle; glycogen synthase 3, brain", "tax_id": 10090, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (mmu:14936); (R-MMU-3322077)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15561936;21183079;21750661;30084848;34428180;39927985;8793107", "class_list": "glycogene;glycosyltransferase", "function": "Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P54859;Q3TBN4;Q8BQG4;Q8VEB0", "ec_number_list": [ { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" }, { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity;GO:0005536 D-glucose binding;GO:0061547 glycogen synthase activity, transferring glucose-1-phosphate", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1902494 catalytic complex;GO:0016234 inclusion body", "go_biological_process": "GO:0007507 heart development;GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z1E4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27661-1", "uniprot_id": [ { "id": "H2AX_MOUSE", "url": "https://www.uniprot.org/uniprot/P27661", "type": "external" } ], "mass": 15143.0, "length": 143, "protein_name": "Histone H2AX", "gene_name": "H2ax", "organism": "Mouse", "refseq_name": "histone H2AX", "refseq_ac": [ { "id": "NP_034566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034566", "type": "external" } ], "gene_names_uniprotkb": "H2ax; H2a.x; H2afx; Hist5-2ax", "gene_names_refseq": "H2A.X; H2afx; H2ax; Hist5-2ax; gammaH2ax", "protein_names_uniprotkb": "Histone H2AX; H2a/x; Histone H2A.X", "protein_names_refseq": "H2A histone family, member X; H2a/x; histone 5 protein 2ax; histone H2A.x; histone H2AX", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); liver benign neoplasm (Disease Ontology:DOID:916); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (mmu:15270); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 18, "publication_count": 39, "publication_id_list": "11242108;11571274;11740565;11934988;12034884;12447390;12660252;12689589;12697768;12792649;12914700;12914701;14530383;15059890;15574327;15580272;15589157;15610743;15632067;19092802;2041781;20488183;21183079;22872234;23039116;23806337;30272023;30746471;30949703;33725478;34428180;35984892;36288343;39627609;7217105;7407044;7774939;9285407;9488723", "class_list": "", "function": "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0003684 damaged DNA binding;GO:0042393 histone binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P27661-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "S4R1E0-1", "uniprot_id": [ { "id": "S4R1E0_MOUSE", "url": "https://www.uniprot.org/uniprot/S4R1E0", "type": "external" } ], "mass": 13384.0, "length": 115, "protein_name": "Histone H2A", "gene_name": "H2ab1", "organism": "Mouse", "refseq_name": "histone H2A", "refseq_ac": [ { "id": "NP_001096135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096135", "type": "external" } ], "gene_names_uniprotkb": "H2ab1; Gm14920", "gene_names_refseq": "Gm14920; Gm1539; H2A.B.3; H2A.Bbd1; H2A.Lap1; H2ab1; H2afb1", "protein_names_uniprotkb": "Histone H2A", "protein_names_refseq": "H2A histone family member B1; histone H2A; predicted pseudogene 14920", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039319); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "S4R1E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL51-1", "uniprot_id": [ { "id": "GSK3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2NL51", "type": "external" } ], "mass": 51661.0, "length": 490, "protein_name": "Glycogen synthase kinase-3 alpha", "gene_name": "Gsk3a", "organism": "Mouse", "refseq_name": "glycogen synthase kinase-3 alpha", "refseq_ac": [ { "id": "NP_001026837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026837", "type": "external" } ], "gene_names_uniprotkb": "Gsk3a", "gene_names_refseq": "2700086H06Rik; Gsk3a", "protein_names_uniprotkb": "Glycogen synthase kinase-3 alpha; 2.7.11.1; 2.7.11.26; GSK-3 alpha; Serine/threonine-protein kinase GSK3A", "protein_names_refseq": "GSK-3 alpha; glycogen synthase kinase-3 alpha; serine/threonine-protein kinase GSK3A", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:606496)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11803463;15791206;16051150;16543145;17391670;17517892;17908561;18824542;19106302;21750661;22539723;22872234;24675832;31219806;34428180;40885482", "class_list": "", "function": "Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:15791206, PubMed:17908561). Requires primed phosphorylation of the majority of its substrates (PubMed:22539723). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:15791206, PubMed:17908561). Regulates glycogen metabolism in liver, but not in muscle (PubMed:17908561). May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:15791206). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (By similarity). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:17391670). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (PubMed:16543145). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q2NL51-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWH3-1", "uniprot_id": [ { "id": "GRHL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FWH3", "type": "external" } ], "mass": 67816.0, "length": 603, "protein_name": "Grainyhead-like protein 3 homolog", "gene_name": "Grhl3", "organism": "Mouse", "refseq_name": "grainyhead-like protein 3 homolog isoform 1", "refseq_ac": [ { "id": "NP_001013778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013778", "type": "external" } ], "gene_names_uniprotkb": "Grhl3; Get1; Som; Tfcp2l4", "gene_names_refseq": "Get1; Grhl3; Som; Tfcp2l4; ct", "protein_names_uniprotkb": "Grainyhead-like protein 3 homolog; Transcription factor CP2-like 4", "protein_names_refseq": "grainyhead-like protein 3 homolog isoform 1; grainyhead-like protein 3 homolog; sister-of-mammalian grainyhead; transcription factor CP2-like 4; transcription factor hSOM1", "tax_id": 10090, "disease": "Van der Woude syndrome (Disease Ontology:DOID:0060239)", "pathway": " (mmu:230824)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14608380;16949565;20654612;21081122;24360809;25347468;29187734", "class_list": "", "function": "Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:20654612, PubMed:21081122, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ADI2", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0032956 regulation of actin cytoskeleton organization;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5FWH3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0GNC1-1", "uniprot_id": [ { "id": "INF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0GNC1", "type": "external" } ], "mass": 138560.0, "length": 1273, "protein_name": "Inverted formin-2", "gene_name": "Inf2", "organism": "Mouse", "refseq_name": "inverted formin-2 isoform 1", "refseq_ac": [ { "id": "NP_940803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940803", "type": "external" } ], "gene_names_uniprotkb": "Inf2", "gene_names_refseq": "2610204M08Rik; EG629699; Inf2", "protein_names_uniprotkb": "Inverted formin-2", "protein_names_refseq": "formin, inverted; inverted formin-2 isoform 1; inverted formin-2", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); Charcot-Marie-Tooth disease dominant intermediate E (Disease Ontology:DOID:0110205); focal segmental glomerulosclerosis 5 (Disease Ontology:DOID:0111130)", "pathway": " (mmu:70435)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "16818491;17242355;19144319;21183079;21750661;21998196;22645316;24788674;25428506;26495903;26740625;28528544;30016717;30084848;31219806;33300544;34428180;38843827", "class_list": "", "function": "Mechanisms of actin filament severing and elongation by formins., [RefSeq, PubMed]; Severs actin filaments and accelerates their polymerization and depolymerization., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q14C56;Q499F7;Q6P9T3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0032535 regulation of cellular component size;GO:0090140 regulation of mitochondrial fission;GO:0045010 actin nucleation;GO:0010467 gene expression;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q0GNC1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C208-1", "uniprot_id": [ { "id": "IKZF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C208", "type": "external" } ], "mass": 64155.0, "length": 586, "protein_name": "Zinc finger protein Eos", "gene_name": "Ikzf4", "organism": "Mouse", "refseq_name": "zinc finger protein Eos isoform 1", "refseq_ac": [ { "id": "NP_035902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035902", "type": "external" } ], "gene_names_uniprotkb": "Ikzf4; Zfpn1a4", "gene_names_refseq": "A630026H08Rik; Eos; Ikzf4; Zfpn1a4; Znfn1a4", "protein_names_uniprotkb": "Zinc finger protein Eos; Ikaros family zinc finger protein 4", "protein_names_refseq": "ikaros family zinc finger protein 4; zinc finger protein Eos isoform 1; zinc finger protein Eos; zinc finger protein, subfamily 1A, 4 (Eos)", "tax_id": 10090, "disease": "encephalomyelitis (Disease Ontology:DOID:640)", "pathway": " (mmu:22781)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10218586;12444977;17403896;19696312;21750661;33300544;37413709;38363226", "class_list": "", "function": "CD4[+] regulatory T cells lacking Helios and Eos., [RefSeq, PubMed]; Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos., [RefSeq, PubMed]; DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (PubMed:19696312)., [UniProtKB, PubMed, PubMed, PubMed]; Data suggest that Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ21;Q3TCZ7;Q9Z2Z2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0032991 protein-containing complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C208-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESJ7-1", "uniprot_id": [ { "id": "IKBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESJ7", "type": "external" } ], "mass": 28861.0, "length": 259, "protein_name": "Interleukin-1 receptor-associated kinase 1-binding protein 1", "gene_name": "Irak1bp1", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001161712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161712", "type": "external" } ], "gene_names_uniprotkb": "Irak1bp1; Aip70; Simpl", "gene_names_refseq": "4921528N06Rik; Aabp3; Aip70; Irak1bp1; Simpl", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase 1-binding protein 1; ActA-binding protein 70; IRAK1-binding protein 1; PLK-interacting protein; SIMPL; Signaling molecule that associates with the mouse pelle-like kinase", "protein_names_refseq": "Acta binding protein 3; Acta-binding protein 70; IRAK1-binding protein 1; Plk-interacting protein; interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 2; signaling molecule that associates with the mouse pelle-like kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:65099)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11096118;11207567;15485901;17079333;17233114;18268037;19941935;20534545;21750661;23630580;25428506", "class_list": "", "function": "Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity., [RefSeq, PubMed]; IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation, [RefSeq, PubMed]; IRAK1BP1 regulates transcription of a specific subset of Toll-like receptor responsive genes, producing an overall antiinflammatory profile, [RefSeq, PubMed]; SIMPL functions as a TNFalpha-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNFalpha-induced genes. Publication Status: Online-Only, [RefSeq, PubMed]; Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that interacts with mouse pelle-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation, [RefSeq, PubMed]; TNF-alpha activation of NF-kappaB dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL, generating a TNF-alpha-specific induction of gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT82;Q8C645;Q9CRM0;Q9CV21;Q9CX27;Q9JK12", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ESJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54890-1", "uniprot_id": [ { "id": "ITB3_MOUSE", "url": "https://www.uniprot.org/uniprot/O54890", "type": "external" } ], "mass": 86738.0, "length": 787, "protein_name": "Integrin beta-3", "gene_name": "Itgb3", "organism": "Mouse", "refseq_name": "integrin beta-3 precursor", "refseq_ac": [ { "id": "NP_058060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058060", "type": "external" } ], "gene_names_uniprotkb": "Itgb3", "gene_names_refseq": "CD61; GP3A; INGRB3; Itgb3", "protein_names_uniprotkb": "Integrin beta-3; GPIIIa; Platelet membrane glycoprotein IIIa", "protein_names_refseq": "GPIIIa; integrin beta-3 precursor; platelet glycoprotein IIIa (GP3A); platelet gpIIIa; platelet membrane glycoprotein IIIa", "tax_id": 10090, "disease": "non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); platelet-type bleeding disorder 16 (Disease Ontology:DOID:0060691); colorectal carcinoma (Disease Ontology:DOID:0080199); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); Graves' disease (Disease Ontology:DOID:12361); thrombocytopenia (Disease Ontology:DOID:1588); cancer (Disease Ontology:DOID:162); blood platelet disease (Disease Ontology:DOID:2218); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); lung non-small cell carcinoma (Disease Ontology:DOID:3908); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); bacterial pneumonia (Disease Ontology:DOID:874); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:16416); (R-MMU-114608); (R-MMU-1566948); (R-MMU-210990); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-4420097); (R-MMU-445144); (R-MMU-5674135); (R-MMU-9769733); (R-MMU-9860927)", "pathway_count": 17, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11323698;11805835;12606711;18483218;18549786;19332769;21183079;22492581;24429998;24935931;29038237;30084848;30899004;34428180;38016540;39145395;39441936;39627609", "class_list": "", "function": "Acute contact with profibrotic macrophages mechanically activates fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1., [RefSeq, PubMed]; Cooperation Between Platelet beta1 and beta3 Integrins in the Arrest of Bleeding Under Inflammatory Conditions in Mice-Brief Report., [RefSeq, PubMed]; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Fibrinogen binding enhances SELP expression in activated platelets (PubMed:19332769). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation (PubMed:11323698). ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a (PubMed:24935931). In brain, plays a role in synaptic transmission and plasticity (PubMed:18549786, PubMed:29038237). Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin (PubMed:29038237). Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (PubMed:18549786). ITGAV:ITGB3 act as a receptor for CD40LG (By similarity). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (By similarity). Integrin ITGA2B:ITGB3 is also the receptor of the erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 21, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZC6", "ec_number_list": [], "go_molecular_function": "GO:0038132 neuregulin binding;GO:0002020 protease binding;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0007044 cell-substrate junction assembly;GO:0010888 negative regulation of lipid storage;GO:0007229 integrin-mediated signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O54890-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61730-1", "uniprot_id": [ { "id": "IL1AP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61730", "type": "external" } ], "mass": 65741.0, "length": 570, "protein_name": "Interleukin-1 receptor accessory protein", "gene_name": "Il1rap", "organism": "Mouse", "refseq_name": "interleukin-1 receptor accessory protein isoform d precursor", "refseq_ac": [ { "id": "NP_001152790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152790", "type": "external" } ], "gene_names_uniprotkb": "Il1rap", "gene_names_refseq": "6430709H04Rik; IL-1RAcP; Il1rap", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein; 3.2.2.6; IL-1 receptor accessory protein; IL-1RAcP; Interleukin-33 receptot beta chain", "protein_names_refseq": "IL-1 receptor accessory protein; interleukin-1 receptor accessory protein isoform d precursor; interleukin-33 receptot beta chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:16180); (R-MMU-1257604); (R-MMU-388844); (R-MMU-6811558); (R-MMU-9014826); (R-MMU-9014843); (R-MMU-9020702)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10854325;11880380;12659850;15986350;17675517;18003919;18450470;19481478;20200353;21349253;21750661;21965679;22159118;22778412;25908590;26495903;28011936;30779550;33300544;34428180;7775431;9862719", "class_list": "", "function": "Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling., [UniProtKB, PubMed, PubMed]; Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVZ1;Q8VCB9", "ec_number_list": [ { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0002114 interleukin-33 receptor activity;GO:0015026 coreceptor activity;GO:0004908 interleukin-1 receptor activity;GO:0005149 interleukin-1 receptor binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0070498 interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q61730-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0D7-1", "uniprot_id": [ { "id": "ING4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0D7", "type": "external" } ], "mass": 28528.0, "length": 249, "protein_name": "Inhibitor of growth protein 4", "gene_name": "Ing4", "organism": "Mouse", "refseq_name": "inhibitor of growth protein 4 isoform 1", "refseq_ac": [ { "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923", "type": "external" } ], "gene_names_uniprotkb": "Ing4", "gene_names_refseq": "D6Wsu147e; D6Xrf92; Ing4; p29ING4", "protein_names_uniprotkb": "Inhibitor of growth protein 4; p29ING4", "protein_names_refseq": "ING1-like protein; inhibitor of growth protein 4 isoform 1; inhibitor of growth protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:28019); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11888890;23806337;35388759;38446206;38968186", "class_list": "", "function": "Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890)., [UniProtKB, PubMed, UniProtKB]; ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development., [RefSeq, PubMed]; Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2)., [RefSeq, PubMed]; Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1S7;Q8K3Q5;Q8K3Q6;Q8K3Q7;Q9D7F9", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045111 intermediate filament cytoskeleton;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0D7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C863-1", "uniprot_id": [ { "id": "ITCH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C863", "type": "external" } ], "mass": 98994.0, "length": 864, "protein_name": "E3 ubiquitin-protein ligase Itchy", "gene_name": "Itch", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Itchy", "refseq_ac": [ { "id": "NP_001230641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230641", "type": "external" } ], "gene_names_uniprotkb": "Itch", "gene_names_refseq": "6720481N21Rik; 8030492O04Rik; A130065M08; AIP4; C230047C07Rik; Itch", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Itchy; 2.3.2.26; HECT-type E3 ubiquitin transferase Itchy homolog", "protein_names_refseq": "E3 ubiquitin-protein ligase Itchy; HECT-type E3 ubiquitin transferase Itchy homolog", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477)", "pathway": " (mmu:16396); (R-MMU-1253288); (R-MMU-168638); (R-MMU-2122948); (R-MMU-5610780); (R-MMU-5632684); (R-MMU-5675482); (R-MMU-8939236); (R-MMU-983168)", "pathway_count": 9, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10940313;11748237;11782481;11828324;15358865;15971201;16387660;16446428;17137798;17437719;17592138;18628966;20392206;23146885;25428506;25632008;26740625;26854353;30084848;30779550;32152506;32513985;34428180;37782276;38029739;40997131;9462742", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:15358865, PubMed:16446428, PubMed:17592138, PubMed:18628966, PubMed:20392206, PubMed:25632008). It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (By similarity). Involved in the control of inflammatory signaling pathways (By similarity). Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (By similarity). Promotes the association of the complex after TNF stimulation (By similarity). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response (PubMed:11828324, PubMed:15358865). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (By similarity). Mediates JUN ubiquitination and degradation (PubMed:15358865). Mediates JUNB ubiquitination and degradation (PubMed:11828324, PubMed:15358865). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (PubMed:11828324). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (By similarity). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (By similarity). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (By similarity). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (By similarity). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:18628966). Ubiquitinates SNX9 (By similarity). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (PubMed:25632008). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (By similarity). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis., [RefSeq, PubMed]; Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54971", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:1990763 arrestin family protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:2000646 positive regulation of receptor catabolic process;GO:0006979 response to oxidative stress;GO:0031623 receptor internalization;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8C863-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUK2-1", "uniprot_id": [ { "id": "IF4H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUK2", "type": "external" } ], "mass": 27341.0, "length": 248, "protein_name": "Eukaryotic translation initiation factor 4H", "gene_name": "Eif4h", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4H isoform 2", "refseq_ac": [ { "id": "NP_001299796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299796", "type": "external" } ], "gene_names_uniprotkb": "Eif4h; Wbscr1", "gene_names_refseq": "D5Ertd355e; E430026L18Rik; Ef4h; Eif4h; Wbscr1; Wscr1; eIF-4H", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4H; Williams-Beuren syndrome chromosomal region 1 protein homolog; eIF-4H", "protein_names_refseq": "eukaryotic translation initiation factor 4H isoform 2; williams-Beuren syndrome chromosomal region 1 protein homolog", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:22384); (R-MMU-156827); (R-MMU-72649); (R-MMU-72662); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "11003705;15592455;22645316;24129315;26495903;34428180;35820727;36288343", "class_list": "", "function": "Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity)., [UniProtKB]; This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUK3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048589 developmental growth", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WUK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59823-1", "uniprot_id": [ { "id": "IRPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59823", "type": "external" } ], "mass": 79630.0, "length": 695, "protein_name": "Interleukin-1 receptor accessory protein-like 1", "gene_name": "Il1rapl1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il1rapl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein-like 1; 3.2.2.6; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 21 (Disease Ontology:DOID:0112022); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:331461); (R-MMU-388844); (R-MMU-9007892)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12783849;21750661;21940441;25908590;30899004;33300544;35820727;39927985;40885482", "class_list": "", "function": "May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:21940441, PubMed:25908590)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0030182 neuron differentiation;GO:0051965 positive regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P59823-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33896-1", "uniprot_id": [ { "id": "INAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P33896", "type": "external" } ], "mass": 65796.0, "length": 590, "protein_name": "Interferon alpha/beta receptor 1", "gene_name": "Ifnar1", "organism": "Mouse", "refseq_name": "interferon alpha/beta receptor 1 precursor", "refseq_ac": [ { "id": "NP_034638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034638", "type": "external" } ], "gene_names_uniprotkb": "Ifnar1; Ifar; Ifnar", "gene_names_refseq": "Ifar; Ifnar1; Ifnar; Ifrc; Infar", "protein_names_uniprotkb": "Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Type I interferon receptor 1", "protein_names_refseq": "IFN-R-1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; INF-a receptor; interferon alpha/beta receptor 1 precursor; interferon alpha/beta receptor 1; type I interferon receptor 1", "tax_id": 10090, "disease": "immunodeficiency 106 (Disease Ontology:DOID:0061075); hepatitis C (Disease Ontology:DOID:1883)", "pathway": " (mmu:15975); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14532120;1533935;18724932;21750661;23872679;24075985;24480543;25428506;7958966", "class_list": "", "function": "Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:14532120, PubMed:1533935, PubMed:24075985). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q80UJ3", "ec_number_list": [], "go_molecular_function": "GO:0019955 cytokine binding;GO:0004904 interferon receptor activity;GO:0008269 JAK pathway signal transduction adaptor activity;GO:0004905 type I interferon receptor activity;GO:0019962 type I interferon binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide;GO:0051607 defense response to virus;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P33896-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0R6-1", "uniprot_id": [ { "id": "ITSN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0R6", "type": "external" } ], "mass": 188908.0, "length": 1659, "protein_name": "Intersectin-2", "gene_name": "Itsn2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Itsn2; Ese2; Sh3d1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Intersectin-2; EH and SH3 domains protein 2; EH domain and SH3 domain regulator of endocytosis 2; SH3 domain-containing protein 1B", "protein_names_refseq": "", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9013420)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10064583;15592455;17242355;17947660;19064729;19131326;19144319;20448150;21183079;21750661;34428180;36852467;40021952;40885482", "class_list": "", "function": "Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9C3;Q9Z0R5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0006897 endocytosis;GO:0007267 cell-cell signaling;GO:0030154 cell differentiation;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z0R6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62101-1", "uniprot_id": [ { "id": "KPCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62101", "type": "external" } ], "mass": 102037.0, "length": 918, "protein_name": "Serine/threonine-protein kinase D1", "gene_name": "Prkd1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase D1 isoform 1", "refseq_ac": [ { "id": "NP_032884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032884", "type": "external" } ], "gene_names_uniprotkb": "Prkd1; Pkcm; Pkd; Prkcm", "gene_names_refseq": "PKD1; PKD; Pkcm; Prkcm; Prkd1; nPKC-D1; nPKC-mu", "protein_names_uniprotkb": "Serine/threonine-protein kinase D1; 2.7.11.13; Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu", "protein_names_refseq": "protein kinase C mu type; protein kinase C, mu; serine/threonine-protein kinase D1 isoform 1; serine/threonine-protein kinase D1", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508); congenital heart disease (Disease Ontology:DOID:1682); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:18760)", "pathway_count": 1, "publication_count": 38, "publication_id_list": "10197446;10473617;11239398;11410586;11514571;11784866;12407104;12477719;14573624;14963034;15084589;15192707;16098040;18164589;19029091;19135240;19289471;20463010;21051537;21132013;21183079;22227248;24161911;24806360;27184844;28716882;29669813;30084848;30779550;31591827;32033440;32351396;35104164;37828378;38419169;38474037;38866124;8078925", "class_list": "", "function": "Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart., [RefSeq, PubMed]; Prkd1 regulates the formation and repair of plasma membrane disruptions (PMD) in osteocytes., [RefSeq, PubMed]; Protein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:12407104, PubMed:14963034, PubMed:15192707, PubMed:20463010, PubMed:24161911, PubMed:28716882). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS) (PubMed:11784866). Acts downstream of the heterotrimeric G protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane (PubMed:11239398). May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-469 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion (PubMed:15192707). In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:19029091). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway (PubMed:14963034, PubMed:20463010). Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:24161911). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:28716882). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (By similarity). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (PubMed:27184844). Acts as a regulator of social behavior by mediating phosphorylation of OXTR, enhancing G(q)-dependent G protein-coupled receptor signaling (PubMed:35104164)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNA3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1904385 cellular response to angiotensin;GO:1990859 cellular response to endothelin;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q62101-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08573-1", "uniprot_id": [ { "id": "LEG9_MOUSE", "url": "https://www.uniprot.org/uniprot/O08573", "type": "external" } ], "mass": 40036.0, "length": 353, "protein_name": "Galectin-9", "gene_name": "Lgals9", "organism": "Mouse", "refseq_name": "galectin-9 isoform 2", "refseq_ac": [ { "id": "NP_001152773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152773", "type": "external" } ], "gene_names_uniprotkb": "Lgals9", "gene_names_refseq": "LGALS35; Lgals5; Lgals9; gal-9; galectin-9", "protein_names_uniprotkb": "Galectin-9; Gal-9", "protein_names_refseq": "galectin-9 isoform 2; lectin, galactose binding, soluble 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:16859)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "16990264;20937702;21670307;21750661;23242525;23408620;25065622;25158758;25605945;26495903;26740625;27802388;28011936;31219806;31599954;34428180;35984892;37453647;37828378;38987795;39627609;9038233;9153289", "class_list": "glycogene", "function": "Acts as an eosinophil chemoattractant (By similarity). It also inhibits angiogenesis (By similarity). Suppresses IFNG production by natural killer cells., [UniProtKB, UniProtKB, PubMed]; Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (PubMed:20937702). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08572;Q3UKE5;Q99L83", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0030246 carbohydrate binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0032823 regulation of natural killer cell differentiation;GO:0006935 chemotaxis;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O08573-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70191-1", "uniprot_id": [ { "id": "TRAF5_MOUSE", "url": "https://www.uniprot.org/uniprot/P70191", "type": "external" } ], "mass": 64145.0, "length": 558, "protein_name": "TNF receptor-associated factor 5", "gene_name": "Traf5", "organism": "Mouse", "refseq_name": "TNF receptor-associated factor 5", "refseq_ac": [ { "id": "NP_035763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035763", "type": "external" } ], "gene_names_uniprotkb": "Traf5", "gene_names_refseq": "Traf5", "protein_names_uniprotkb": "TNF receptor-associated factor 5", "protein_names_refseq": "TNF receptor-associated factor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:22033)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15121867;21750661;23542741;25428506;30084848;34348490;34428180;34996840;37575027;38642079;40021952;8663299;8790348", "class_list": "", "function": "Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR., [UniProtKB, PubMed]; Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice., [RefSeq, PubMed]; TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes., [RefSeq, PubMed]; TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice., [RefSeq, PubMed]; Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARgamma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61480", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0031996 thioesterase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0035631 CD40 receptor complex", "go_biological_process": "GO:0023035 CD40 signaling pathway;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70191-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61143-1", "uniprot_id": [ { "id": "TRPC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61143", "type": "external" } ], "mass": 106681.0, "length": 930, "protein_name": "Short transient receptor potential channel 6", "gene_name": "Trpc6", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 6 isoform 1", "refseq_ac": [ { "id": "NP_038866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038866", "type": "external" } ], "gene_names_uniprotkb": "Trpc6; Trp6; Trrp6", "gene_names_refseq": "LLHWJM002; LLHWJM003; LLHWJM004; TRP-6; Trpc6; Trrp6; mtrp6", "protein_names_uniprotkb": "Short transient receptor potential channel 6; Calcium entry channel; TRP-6; Transient receptor protein 6; TrpC6", "protein_names_refseq": "calcium entry channel; short transient receptor potential channel 6 isoform 1; short transient receptor potential channel 6; transient receptor protein 6", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); focal segmental glomerulosclerosis 2 (Disease Ontology:DOID:0111129); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); transient cerebral ischemia (Disease Ontology:DOID:224); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); chronic fatigue syndrome (Disease Ontology:DOID:8544); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:22068); (R-MMU-114508); (R-MMU-139853); (R-MMU-3295583)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10050885;14761972;21183079;22051675;23814119;36068079;39134250;8646775;9368034", "class_list": "", "function": "Non-selective, calcium-permeable cation channel (PubMed:9368034). Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol (DAG) that directly activates TRPC6 (PubMed:22051675, PubMed:9368034). Does not appear to be activated by depletion of intracellular calcium stores (By similarity). Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (PubMed:22051675)., [UniProtKB, UniProtKB, PubMed, PubMed]; TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca[2+]/CaMKII signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EIW2;Q9Z2J1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0003779 actin binding;GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0036057 slit diaphragm", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0045666 positive regulation of neuron differentiation;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61143-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26039-1", "uniprot_id": [ { "id": "TLN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P26039", "type": "external" } ], "mass": 269821.0, "length": 2541, "protein_name": "Talin-1", "gene_name": "Tln1", "organism": "Mouse", "refseq_name": "talin-1", "refseq_ac": [ { "id": "NP_035732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035732", "type": "external" } ], "gene_names_uniprotkb": "Tln1; Tln", "gene_names_refseq": "Tln1; Tln", "protein_names_uniprotkb": "Talin-1", "protein_names_refseq": "talin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21894); (R-MMU-114608); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-399955); (R-MMU-445355); (R-MMU-5674135)", "pathway_count": 8, "publication_count": 45, "publication_id_list": "10807784;15272303;15592455;15623515;15642262;16075062;18034455;18630941;19224205;20173027;20610383;21183079;2120593;21750661;21768292;22872234;23386199;23389036;23806337;25428506;26495903;26740625;27410476;28011936;29187734;30016717;30084848;30779550;31219806;32152506;32782141;33725478;34203471;34428180;35820727;35984892;36210013;36288343;36792666;37453647;37507081;37828378;39627609;39927985;7622520", "class_list": "", "function": "High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2AIM8;Q8VEF0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0017166 vinculin binding;GO:0030274 LIM domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0007044 cell-substrate junction assembly;GO:0007229 integrin-mediated signaling pathway;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P26039-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922J3-1", "uniprot_id": [ { "id": "CLIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922J3", "type": "external" } ], "mass": 155814.0, "length": 1391, "protein_name": "CAP-Gly domain-containing linker protein 1", "gene_name": "Clip1", "organism": "Mouse", "refseq_name": "CAP-Gly domain-containing linker protein 1 isoform b", "refseq_ac": [ { "id": "NP_001278158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278158", "type": "external" } ], "gene_names_uniprotkb": "Clip1; Kiaa4046; Rsn", "gene_names_refseq": "1110007I12Rik; 4631429H07Rik; CLIP-170; CLIP170; CYLN1; Clip1; Clip50; Rsn; mKIAA4046; restin", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 1; CLIP-170; Cytoplasmic linker protein 170; Restin", "protein_names_refseq": "CAP-Gly domain-containing linker protein 1 isoform b; CAP-Gly domain-containing linker protein 1; Clip 170; Reed-Steinberg cell-espressed intermediate filament-associated protein; cytoplasmic linker protein 170; cytoplasmic linker protein 50; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)", "tax_id": 10090, "disease": "", "pathway": " (mmu:56430); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16954346;17242355;18854161;21183079;21750661;22517741;22645316;26495903;26972003;32491151;32782141;33251722;34428180;35348691;35547804;36288343;38705933;39927985;40021952;40885482", "class_list": "", "function": "AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170., [RefSeq, PubMed]; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking., [UniProtKB, UniProtKB]; CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-beta pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency., [RefSeq, PubMed]; Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q571L7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0031116 positive regulation of microtubule polymerization;GO:0044861 protein transport into plasma membrane raft;GO:1900006 positive regulation of dendrite development;GO:0001578 microtubule bundle formation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q922J3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8I9-1", "uniprot_id": [ { "id": "FRY_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8I9", "type": "external" } ], "mass": 339093.0, "length": 3020, "protein_name": "Protein furry homolog", "gene_name": "Fry", "organism": "Mouse", "refseq_name": "protein furry homolog", "refseq_ac": [ { "id": "NP_766475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766475", "type": "external" } ], "gene_names_uniprotkb": "Fry; Kiaa4143", "gene_names_refseq": "13CDNA73; 9330186A19Rik; D930046M03; Fry; cg003; mKIAA4143", "protein_names_uniprotkb": "Protein furry homolog", "protein_names_refseq": "furry homolog; protein furry homolog", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:320365)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22753416;33300544;34428180;35820727", "class_list": "", "function": "Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA57;Q5DTL4;Q8BIW6;Q8BUA0;Q8CG91", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005938 cell cortex;GO:0030427 site of polarized growth", "go_biological_process": "GO:0031175 neuron projection development;GO:0000902 cell morphogenesis;GO:1904428 negative regulation of tubulin deacetylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "E9Q8I9-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571F8-1", "uniprot_id": [ { "id": "GLSL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571F8", "type": "external" } ], "mass": 66366.0, "length": 602, "protein_name": "Glutaminase liver isoform, mitochondrial", "gene_name": "Gls2", "organism": "Mouse", "refseq_name": "glutaminase liver isoform, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_001028436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028436", "type": "external" } ], "gene_names_uniprotkb": "Gls2; Kiaa4146", "gene_names_refseq": "A330074B06Rik; GA; GLS; Gls2; Lga", "protein_names_uniprotkb": "Glutaminase liver isoform, mitochondrial; 3.5.1.2; GLS; L-glutaminase; L-glutamine amidohydrolase; LGA", "protein_names_refseq": "L-glutaminase; L-glutamine amidohydrolase; glutaminase liver isoform, mitochondrial isoform 1 precursor; liver mitochondrial glutaminase", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 71 (Disease Ontology:DOID:0112207)", "pathway": " (mmu:216456); (R-MMU-210500); (R-MMU-5628897); (R-MMU-8964539)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "20173027;20351271;21750661;22228304;23576753;23806337;23935106;30084848;34428180;37453647", "class_list": "", "function": "Phosphate-activated glutaminase (GLS2) is a p53-inducible regulator of glutamine metabolism and reactive oxygen species, [RefSeq, PubMed]; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUF2;Q3TMJ6", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0072593 reactive oxygen species metabolic process;GO:0006537 glutamate biosynthetic process;GO:0006543 L-glutamine catabolic process;GO:0006541 glutamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q571F8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0L9-1", "uniprot_id": [ { "id": "GPCP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0L9", "type": "external" } ], "mass": 76579.0, "length": 675, "protein_name": "Glycerophosphocholine phosphodiesterase GPCPD1", "gene_name": "Gpcpd1", "organism": "Mouse", "refseq_name": "glycerophosphocholine phosphodiesterase GPCPD1 isoform 1", "refseq_ac": [ { "id": "NP_001277979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277979", "type": "external" } ], "gene_names_uniprotkb": "Gpcpd1; Gde5; Kiaa1434; Prei4", "gene_names_refseq": "2310004G06Rik; 2310032D16Rik; Gde5; Gpcpd1; Prei4; mKIAA1434", "protein_names_uniprotkb": "Glycerophosphocholine phosphodiesterase GPCPD1; 3.1.4.2; Glycerophosphodiester phosphodiesterase 5; Preimplantation protein 4", "protein_names_refseq": "glycerophosphocholine phosphodiesterase GDE1 homolog; glycerophosphocholine phosphodiesterase GPCPD1 isoform 1; preimplantation protein 4; putative glycerophosphocholine phosphodiesterase GPCPD1; putative glycerophosphodiester phosphodiesterase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74182)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18034455;19224205;20173027;20576599;21183079;21750661;30462540;34203471;34428180;35820727;37507081;38238601", "class_list": "glycogene", "function": "Decreased GDE5 expression suppresses adipocyte differentiation by intracellular glycerophosphocholine accumulation., [RefSeq, PubMed]; GDE5 negatively regulates skeletal muscle development., [RefSeq, PubMed]; Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism., [RefSeq, PubMed]; Shows strong preference for glycerophosphocholine (PubMed:20576599). Displays weak activity toward glycerophosphoethanolamine and no detectable activity toward glycerophosphoglycerol, glycerophosphoserine, or glycerophosphoinositol (PubMed:20576599). May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMD5;Q3TLV6;Q80TD5;Q8BKJ7;Q8BKW7;Q8CFW2;Q9D759", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.2", "type": "external" } ], "go_molecular_function": "GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:2001070 starch binding;GO:0047389 glycerophosphocholine phosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:0007519 skeletal muscle tissue development;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8C0L9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08917-1", "uniprot_id": [ { "id": "FLOT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08917", "type": "external" } ], "mass": 47513.0, "length": 428, "protein_name": "Flotillin-1", "gene_name": "Flot1", "organism": "Mouse", "refseq_name": "flotillin-1 isoform 1", "refseq_ac": [ { "id": "NP_032053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032053", "type": "external" } ], "gene_names_uniprotkb": "Flot1", "gene_names_refseq": "Flot1; reggie-2", "protein_names_uniprotkb": "Flotillin-1", "protein_names_refseq": "flotillin-1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14251); (R-MMU-5213460); (R-MMU-5675482); (R-MMU-8849932); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10212252;21750661;26495903;29187734;30452906;31548330;34428180;37828378;9153235", "class_list": "", "function": "Flot1 plays a detectable but unexpectedly minor role for CD8(+) T cell behavior under physiological conditions., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles., [UniProtKB]; The presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007409 axonogenesis;GO:0022617 extracellular matrix disassembly;GO:0035556 intracellular signal transduction;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08917-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z430-1", "uniprot_id": [ { "id": "D3Z430_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z430", "type": "external" } ], "mass": 16279.0, "length": 149, "protein_name": "Ciliary microtubule inner protein 5", "gene_name": "Cimip5", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf50 homolog isoform 1", "refseq_ac": [ { "id": "NP_001188261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188261", "type": "external" } ], "gene_names_uniprotkb": "Cimip5; 2410004P03Rik", "gene_names_refseq": "2410004P03Rik; Cimip5", "protein_names_uniprotkb": "Ciliary microtubule inner protein 5", "protein_names_refseq": "uncharacterized protein C2orf50 homolog isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73667)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z430-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWK3-1", "uniprot_id": [ { "id": "CD2B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWK3", "type": "external" } ], "mass": 37694.0, "length": 342, "protein_name": "CD2 antigen cytoplasmic tail-binding protein 2", "gene_name": "Cd2bp2", "organism": "Mouse", "refseq_name": "CD2 antigen cytoplasmic tail-binding protein 2", "refseq_ac": [ { "id": "NP_001272834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272834", "type": "external" } ], "gene_names_uniprotkb": "Cd2bp2", "gene_names_refseq": "1500011B02Rik; 2410024K20Rik; Cd2bp2", "protein_names_uniprotkb": "CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2", "protein_names_refseq": "CD2 antigen (cytoplasmic tail) binding protein 2; CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70233)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16452087;21183079;21750661;23806337;31219806;34428180", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJX5", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0001650 fibrillar center", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CWK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16092-1", "uniprot_id": [ { "id": "FGFR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P16092", "type": "external" } ], "mass": 91981.0, "length": 822, "protein_name": "Fibroblast growth factor receptor 1", "gene_name": "Fgfr1", "organism": "Mouse", "refseq_name": "fibroblast growth factor receptor 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001073377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073377", "type": "external" } ], "gene_names_uniprotkb": "Fgfr1; Flg", "gene_names_refseq": "Eask; FGFR-I; FLG; Fgfr-1; Fgfr1; Flt-2; Fr1; Hspy; MFR; bFGF-R-1; c-fgr", "protein_names_uniprotkb": "Fibroblast growth factor receptor 1; 2.7.10.1; Basic fibroblast growth factor receptor 1; FGFR-1; MFR; Proto-oncogene c-Fgr; bFGF-R-1", "protein_names_refseq": "basic fibroblast growth factor receptor 1; fibroblast growth factor receptor 1 isoform 2 precursor; proto-oncogene c-Fgr", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); atypical chronic myeloid leukemia, BCR-ABL1 negative (Disease Ontology:DOID:0060597); myeloid neoplasm (Disease Ontology:DOID:0070004); bone disease (Disease Ontology:DOID:0080001); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 2 with or without anosmia (Disease Ontology:DOID:0090083); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); osteoglophonic dysplasia (Disease Ontology:DOID:0111532); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); acrocephalosyndactylia (Disease Ontology:DOID:12960); Pfeiffer syndrome (Disease Ontology:DOID:14705); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mouth disease (Disease Ontology:DOID:403); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); fibrolamellar carcinoma (Disease Ontology:DOID:5015); retinal detachment (Disease Ontology:DOID:5327); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14182); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190370); (R-MMU-190373); (R-MMU-190374); (R-MMU-445144); (R-MMU-5654219); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654726); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 15, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10821861;10896947;12034712;12181353;1309590;15383174;16731982;16872596;1689490;1708247;17086194;17452648;17728342;19349973;19549074;21540332;2161096;2161540;21750661;26495903;26740625;30899004;31097591;32024006;34428180;35820727;36210013;36852467;37828378;7802632;7897669;8001822;8001823;8663044", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 33, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2P4;Q01736;Q60830;Q61562;Q80T10;Q8CFK8;Q9QZM7", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001759 organ induction;GO:0010966 regulation of phosphate transport;GO:0051174 regulation of phosphorus metabolic process;GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1904383 response to sodium phosphate", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P16092-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMF0-1", "uniprot_id": [ { "id": "COBL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMF0", "type": "external" } ], "mass": 137382.0, "length": 1273, "protein_name": "Cordon-bleu protein-like 1", "gene_name": "Cobll1", "organism": "Mouse", "refseq_name": "cordon-bleu protein-like 1 isoform 2", "refseq_ac": [ { "id": "NP_081501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081501", "type": "external" } ], "gene_names_uniprotkb": "Cobll1; Coblr1; Kiaa0977", "gene_names_refseq": "1810047P18Rik; Cobll1; Coblr1; D430044D16Rik", "protein_names_uniprotkb": "Cordon-bleu protein-like 1; Cobl-related protein 1", "protein_names_refseq": "cobl-related 1; cobl-related protein 1; cordon-bleu protein-like 1 isoform 2; cordon-bleu protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319876)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14512015;17242355;18630941;20173027;21183079;21750661;25153642;26495903;28135057;30059200;32782141;34428180;35820727;36288343;36852467;37507081;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UX63;Q69ZU2;Q6NXM0;Q7TQM8;Q8BWH3", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding", "go_cellular_component": "GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q3UMF0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A571BEN1-1", "uniprot_id": [ { "id": "A0A571BEN1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A571BEN1", "type": "external" } ], "mass": 128025.0, "length": 1139, "protein_name": "Myosin-binding protein C, slow-type", "gene_name": "Mybpc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mybpc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-binding protein C, slow-type; C-protein, skeletal muscle slow isoform", "protein_names_refseq": "", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); lethal congenital contracture syndrome 4 (Disease Ontology:DOID:0060654); congenital myopathy (Disease Ontology:DOID:0081337); congenital myopathy 16 (Disease Ontology:DOID:0081348); distal arthrogryposis type 1B (Disease Ontology:DOID:0111598); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:109272); (R-MMU-390522)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin. In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0017022 myosin binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0032982 myosin filament;GO:0005856 cytoskeleton;GO:0031430 M band", "go_biological_process": "GO:0007155 cell adhesion;GO:0060048 cardiac muscle contraction;GO:0006936 muscle contraction;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A571BEN1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35922-1", "uniprot_id": [ { "id": "FMR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35922", "type": "external" } ], "mass": 68890.0, "length": 614, "protein_name": "Fragile X messenger ribonucleoprotein 1", "gene_name": "Fmr1", "organism": "Mouse", "refseq_name": "fragile X messenger ribonucleoprotein 1 isoform 1", "refseq_ac": [ { "id": "NP_032057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032057", "type": "external" } ], "gene_names_uniprotkb": "Fmr1; Fmr-1", "gene_names_refseq": "FMRP; Fmr-1; Fmr1", "protein_names_uniprotkb": "Fragile X messenger ribonucleoprotein 1; FMRP; Fragile X messenger ribonucleoprotein; Protein FMR-1; mFmr1p", "protein_names_refseq": "FMRP translational regulator 1; fragile X messenger ribonucleoprotein 1 isoform 1; synaptic functional regulator FMR1", "tax_id": 10090, "disease": "fragile X-associated tremor/ataxia syndrome (Disease Ontology:DOID:0050879); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); primary ovarian insufficiency 1 (Disease Ontology:DOID:0080857); fragile X syndrome (Disease Ontology:DOID:14261); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); glucose metabolism disease (Disease Ontology:DOID:4194); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (mmu:14265)", "pathway_count": 1, "publication_count": 72, "publication_id_list": "10.1101/2023.09.13.557529;10556305;10567518;11162447;11376146;11438589;11438699;11719188;12032354;12147688;12417522;12575950;12581522;12927206;14570712;14613971;14614133;15028757;15312650;15317853;15329415;15381419;15475576;15548614;15805463;16000371;16098134;16319129;16631377;16675531;16790844;16908410;17417632;17507556;17548835;18093976;18539120;18653529;18805096;19166269;19193898;19640847;20159450;20512134;21183079;21490210;21750661;21784246;23235829;23891804;24129315;24349419;24709664;24813610;25464849;25561520;25692235;27957526;28135057;29187734;31219806;31340148;31753916;34887587;36852467;40885482;8358432;8842725;8895584;9144249;9259278;9285783", "class_list": "", "function": "Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:11438589, PubMed:12032354, PubMed:15475576, PubMed:16631377, PubMed:16790844, PubMed:17417632, PubMed:17548835, PubMed:18539120, PubMed:18653529, PubMed:19166269, PubMed:19640847, PubMed:20159450, PubMed:21784246, PubMed:23235829, PubMed:24813610). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein MBP mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (PubMed:17417632). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (PubMed:18539120). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11376146, PubMed:12581522, PubMed:12927206, PubMed:14570712, PubMed:15475576, PubMed:16908410, PubMed:18805096, PubMed:19640847, PubMed:21784246, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (PubMed:18805096). Represses mRNA translation by stalling ribosomal translocation during elongation (PubMed:21784246). Reports are contradictory with regards to its ability to mediate translation inhibition of (MBP) mRNA in oligodendrocytes (PubMed:14613971, PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:20159450, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (By similarity). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:14613971, PubMed:14614133, PubMed:15548614, PubMed:19166269, PubMed:19640847, PubMed:21490210). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (PubMed:16908410, PubMed:17507556, PubMed:19640847). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11376146, PubMed:11719188, PubMed:14613971, PubMed:17507556, PubMed:21490210, PubMed:21784246, PubMed:24349419). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (By similarity). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (By similarity). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (By similarity). Binds mRNAs containing U-rich target sequences (By similarity). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (PubMed:12581522, PubMed:18805096). Plays a role in mRNA nuclear export (PubMed:16790844, PubMed:31340148, PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31340148, PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (PubMed:17548835). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (PubMed:17548835). Binds to a subset of miRNAs in the brain (PubMed:20159450). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (By similarity). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (By similarity). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (PubMed:24709664). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (PubMed:15475576). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXB7", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0098976 excitatory chemical synaptic transmission;GO:0098817 evoked excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 7.8, "record_id": "P35922-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z0K6-1", "uniprot_id": [ { "id": "D3Z0K6_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z0K6", "type": "external" } ], "mass": 91746.0, "length": 821, "protein_name": "Round spermatid basic protein 1-like", "gene_name": "Rsbn1l", "organism": "Mouse", "refseq_name": "lysine-specific demethylase RSBN1L", "refseq_ac": [ { "id": "NP_001074446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074446", "type": "external" } ], "gene_names_uniprotkb": "Rsbn1l", "gene_names_refseq": "8430412F05Rik; C330002G24Rik; Rsbn1l", "protein_names_uniprotkb": "Round spermatid basic protein 1-like", "protein_names_refseq": "lysine-specific demethylase RSBN1L", "tax_id": 10090, "disease": "", "pathway": " (mmu:242860)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;40997131", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140457 protein demethylase activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z0K6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0A3-1", "uniprot_id": [ { "id": "CHMP6_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C0A3", "type": "external" } ], "mass": 23416.0, "length": 200, "protein_name": "Charged multivesicular body protein 6", "gene_name": "Chmp6", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 6", "refseq_ac": [ { "id": "NP_001078967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078967", "type": "external" } ], "gene_names_uniprotkb": "Chmp6", "gene_names_refseq": "2400004G01Rik; Chmp6", "protein_names_uniprotkb": "Charged multivesicular body protein 6; Chromatin-modifying protein 6", "protein_names_refseq": "charged multivesicular body protein 6; chromatin modifying protein 6; novel SNF7 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:208092); (R-MMU-1632852); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0061763 multivesicular body-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C0A3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4H9-1", "uniprot_id": [ { "id": "NCOA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4H9", "type": "external" } ], "mass": 70381.0, "length": 625, "protein_name": "Nuclear receptor coactivator 4", "gene_name": "Ncoa4", "organism": "Mouse", "refseq_name": "nuclear receptor coactivator 4 isoform a", "refseq_ac": [ { "id": "NP_001029160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029160", "type": "external" } ], "gene_names_uniprotkb": "Ncoa4; Rfg", "gene_names_refseq": "ARA70; NCoA-4; Ncoa4; Rfg", "protein_names_uniprotkb": "Nuclear receptor coactivator 4; Androgen receptor coactivator protein; Ferritin cargo receptor NCOA4; NCoA-4", "protein_names_refseq": "androgen receptor coactivator protein; ferritin cargo receptor NCOA4; nuclear receptor coactivator 4 isoform a", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); polycystic ovary syndrome (Disease Ontology:DOID:11612); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (mmu:27057)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "16110473;20167864;20354146;20814820;21750661;24695223;24910095;25327288;25428506;26495903;26776506;30779550;38388414;38688134;39166386;39206719", "class_list": "", "function": "ARA70alpha functions as a tumor suppressor gene, [RefSeq, PubMed]; Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:24695223, PubMed:25327288, PubMed:26776506). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:24695223, PubMed:26776506). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (By similarity). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26776506). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (By similarity). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (By similarity). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (By similarity). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Data suggest that myostatin decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR, [RefSeq, PubMed]; FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy., [RefSeq, PubMed]; High ARA70alpha inhibited cell proliferation, and that ARA70beta promotes proliferation in breast cancer., [RefSeq, PubMed]; Lactylation of nuclear receptor coactivator 4 promotes ferritinophagy and glycolysis of neuronal cells after cerebral ischemic injury., [RefSeq, PubMed]; Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion., [RefSeq, PubMed]; Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor, during development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI10;Q3UJ26;Q3UJ63;Q3UKL9;Q9WV42", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0005694 chromosome", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0009725 response to hormone;GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5U4H9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXT8-1", "uniprot_id": [ { "id": "CSEN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXT8", "type": "external" } ], "mass": 29463.0, "length": 256, "protein_name": "Calsenilin", "gene_name": "Kcnip3", "organism": "Mouse", "refseq_name": "calsenilin isoform b", "refseq_ac": [ { "id": "NP_001104801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104801", "type": "external" } ], "gene_names_uniprotkb": "Kcnip3; Csen; Dream; Kchip3", "gene_names_refseq": "4933407H12Rik; Csen; DREAM; KChIP3; Kcnip3", "protein_names_uniprotkb": "Calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; KChIP3; Kv channel-interacting protein 3", "protein_names_refseq": "A-type potassium channel modulatory protein 3; DRE-antagonist modulator; calsenilin isoform b; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin/KChIP3 T+; calsenilin/KChIP3 T-; downstream regulatory element antagonist T+; downstream regulatory element antagonist T-; kv channel-interacting protein 3; potassium channel interacting protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56461); (R-MMU-5576894)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10676964;11161465;11598014;11792319;12451113;12646414;14534243;15363885;15746104;18201103;19713751;20943905;21183079;21750661;22311982", "class_list": "", "function": "Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception., [UniProtKB, PubMed, PubMed]; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity)., [UniProtKB, UniProtKB]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner., [UniProtKB, PubMed, PubMed]; Unknown for isoform 4. Csen is involved in calcium-dependent transcriptional repression, regulation of potassium channels, and perhaps in processing of PSEN2 and apoptosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q924L0;Q99PH9;Q99PI0;Q99PI2;Q99PI3;Q9JHZ5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0005267 potassium channel activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008076 voltage-gated potassium channel complex;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXT8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHR8-1", "uniprot_id": [ { "id": "CSTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHR8", "type": "external" } ], "mass": 37550.0, "length": 331, "protein_name": "Centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "gene_name": "Cstpp1", "organism": "Mouse", "refseq_name": "centriolar satellite-associated tubulin polyglutamylase complex regulator 1 isoform 1", "refseq_ac": [ { "id": "NP_001298073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298073", "type": "external" } ], "gene_names_uniprotkb": "Cstpp1", "gene_names_refseq": "1110051M20Rik; Cstpp1", "protein_names_uniprotkb": "Centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "protein_names_refseq": "UPF0705 protein C11orf49 homolog; centriolar satellite-associated tubulin polyglutamylase complex regulator 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228356)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;21183079;21750661;22645316;30084848;34428180;40021952;40885482", "class_list": "", "function": "Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPK0;Q5HZI4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization;GO:0061635 regulation of protein complex stability;GO:0061523 cilium disassembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVZ3-1", "uniprot_id": [ { "id": "E9PVZ3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVZ3", "type": "external" } ], "mass": 61382.0, "length": 520, "protein_name": "Gene model 57858", "gene_name": "Gm57858", "organism": "Mouse", "refseq_name": "coiled-coil domain containing 144B isoform 2", "refseq_ac": [ { "id": "NP_848505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848505", "type": "external" } ], "gene_names_uniprotkb": "Gm57858; Ccdc144b", "gene_names_refseq": "Ccdc144b; Gm57858", "protein_names_uniprotkb": "Gene model 57858", "protein_names_refseq": "coiled-coil domain containing 144B isoform 2; coiled-coil domain containing 144B", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PVZ3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23819-1", "uniprot_id": [ { "id": "GRIA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P23819", "type": "external" } ], "mass": 98662.0, "length": 883, "protein_name": "Glutamate receptor 2", "gene_name": "Gria2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gria2; GluA2; Glur2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate receptor 2; AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); morphine dependence (Disease Ontology:DOID:2560); central nervous system disease (Disease Ontology:DOID:331); amphetamine abuse (Disease Ontology:DOID:670); cannabis abuse (Disease Ontology:DOID:9505); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-MMU-399710); (R-MMU-416993); (R-MMU-438066)", "pathway_count": 3, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10340301;10501226;10558890;12458226;12805550;14687553;15240807;16129400;1699805;1717158;18341993;19746427;20152115;20547133;20696523;21183079;21496646;21750661;22325330;23524343;25218043;25547463;28063882;28835690;30699097;30899004;31847086;31969804;32948689;33300544;40885482;7545935", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 10, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q61604;Q61605;Q8BG69;Q8BXU3;Q9D6D3", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0031623 receptor internalization;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0051262 protein tetramerization", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P23819-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61098-1", "uniprot_id": [ { "id": "IL18R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61098", "type": "external" } ], "mass": 61601.0, "length": 537, "protein_name": "Interleukin-18 receptor 1", "gene_name": "Il18r1", "organism": "Mouse", "refseq_name": "interleukin-18 receptor 1 isoform a precursor", "refseq_ac": [ { "id": "NP_032391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032391", "type": "external" } ], "gene_names_uniprotkb": "Il18r1", "gene_names_refseq": "Il18r1; Il18ralpha; Il1rrp", "protein_names_uniprotkb": "Interleukin-18 receptor 1; 3.2.2.6; CD218 antigen-like family member A; IL-18R-1; IL-18R-alpha; IL-18R1; IL-18Ralpha; IL-1Rrp; IL1 receptor-related protein; IL1R-rp; Interleukin-18 receptor alpha", "protein_names_refseq": "CD218 antigen-like family member A; IL-18R-1; IL-18R-alpha; IL-18R1; IL-18Ralpha; IL-1Rrp; IL1 receptor-related protein; IL1R-rp; interleukin 1 receptor related protein; interleukin-18 receptor 1 isoform a precursor; interleukin-18 receptor alpha", "tax_id": 10090, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:16182); (R-MMU-9012546)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15323361;21750661;26099046;40885482;8626725", "class_list": "", "function": "Review of structure, function and tissue distribution of IL-18R [review] Review article, [RefSeq, PubMed]; Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0042007 interleukin-18 binding;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0042008 interleukin-18 receptor activity", "go_cellular_component": "GO:0045092 interleukin-18 receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0006954 inflammatory response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response;GO:0032729 positive regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61098-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6S9-1", "uniprot_id": [ { "id": "CFA54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6S9", "type": "external" } ], "mass": 353760.0, "length": 3106, "protein_name": "Cilia- and flagella-associated protein 54", "gene_name": "Cfap54", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 54", "refseq_ac": [ { "id": "NP_001333989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333989", "type": "external" } ], "gene_names_uniprotkb": "Cfap54; 4930485B16Rik", "gene_names_refseq": "4930485B16Rik; Cfap54; Gm872", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 54", "protein_names_refseq": "cilia- and flagella-associated protein 54; ciliary and flagellar protein 54", "tax_id": 10090, "disease": "", "pathway": " (mmu:380654)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26224312;32704025", "class_list": "", "function": "Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia. Publication Status: Online-Only, [RefSeq, PubMed]; Required for assembly and function of cilia and flagella (PubMed:26224312)., [UniProtKB, PubMed]; This study identifies a critical role for CFAP54 in proper assembly and function of mammalian cilia and flagella and establishes the gene-trapped allele as a new model of PCD, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0K0NTX9;D3Z3Q2;E9PUV7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005930 axoneme", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0007283 spermatogenesis;GO:0060271 cilium assembly;GO:0044458 motile cilium assembly;GO:0090660 cerebrospinal fluid circulation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C6S9-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YUJ6-1", "uniprot_id": [ { "id": "D3YUJ6_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YUJ6", "type": "external" } ], "mass": 55124.0, "length": 481, "protein_name": "PRAME like 56; PRAME like 60", "gene_name": "Pramel56", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041253", "refseq_ac": [ { "id": "NP_001186984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186984", "type": "external" } ], "gene_names_uniprotkb": "Pramel56; LOC100038995; LOC100041712; LOC100862245; Pramel60", "gene_names_refseq": "Gm16513; Pramel60", "protein_names_uniprotkb": "PRAME like 56; PRAME like 60", "protein_names_refseq": "uncharacterized protein LOC100041253", "tax_id": 10090, "disease": "", "pathway": " (mmu:100038995); (mmu:100041179); (mmu:100041253); (mmu:100041712); (mmu:100862245)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YUJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70496-1", "uniprot_id": [ { "id": "CLCN7_MOUSE", "url": "https://www.uniprot.org/uniprot/O70496", "type": "external" } ], "mass": 88713.0, "length": 803, "protein_name": "H(+)/Cl(-) exchange transporter 7", "gene_name": "Clcn7", "organism": "Mouse", "refseq_name": "H(+)/Cl(-) exchange transporter 7 isoform 1", "refseq_ac": [ { "id": "NP_036060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036060", "type": "external" } ], "gene_names_uniprotkb": "Clcn7; Clc7", "gene_names_refseq": "ClC-7; Clcn7; D17Wsu51e", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 7 isoform 1; chloride channel 7 alpha subunit; chloride channel protein 7; h(+)/Cl(-) exchange transporter 7", "tax_id": 10090, "disease": "autosomal dominant osteopetrosis 2 (Disease Ontology:DOID:0110938); autosomal recessive osteopetrosis 4 (Disease Ontology:DOID:0110944); osteopetrosis (Disease Ontology:DOID:13533); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:26373); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11207362;15706348;16525474;18250455;19144319;19661288;21750661;31155284;32152506;33495814;34428180;35820727;36513280;37363915;38136669", "class_list": "", "function": "CLCN7, a gene shared by autosomal recessive and autosomal dominant osteopetrosis., [RefSeq, PubMed]; ClC-7 knockout mice display neurodegeneration and severe lysosomal storage disease despite unchanged lysosomal pH in cultured neurons., [RefSeq, PubMed]; H(+)/Cl() exchange transporter 7 promotes lysosomal acidificationmediated autophagy in mouse cardiomyocytes., [RefSeq, PubMed]; Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl[-]/H[+] Exchanger ClC-7. Publication Status: Online-Only, [RefSeq, PubMed]; Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:16525474, PubMed:19661288). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:16525474, PubMed:19661288). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters., [UniProtKB, UniProtKB, UniProtKB]; The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0062158 chloride:proton antiporter activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0034707 chloride channel complex;GO:0016020 membrane", "go_biological_process": "GO:0009268 response to pH;GO:1902476 chloride transmembrane transport;GO:0030321 transepithelial chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O70496-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5C0-1", "uniprot_id": [ { "id": "GRHL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K5C0", "type": "external" } ], "mass": 71195.0, "length": 625, "protein_name": "Grainyhead-like protein 2 homolog", "gene_name": "Grhl2", "organism": "Mouse", "refseq_name": "grainyhead-like protein 2 homolog", "refseq_ac": [ { "id": "NP_080772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080772", "type": "external" } ], "gene_names_uniprotkb": "Grhl2; Bom; Tcfcp2l3", "gene_names_refseq": "0610015A08Rik; BOM; Grhl2; Tcfcp2l3; clft3", "protein_names_uniprotkb": "Grainyhead-like protein 2 homolog; Brother of mammalian grainyhead; Transcription factor CP2-like 3", "protein_names_refseq": "brother of mammalian grainyhead; grainyhead like 2; grainyhead-like 2; grainyhead-like protein 2 homolog; grainyheadlike; transcription factor CP2-like 3", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); posterior polymorphous corneal dystrophy 4 (Disease Ontology:DOID:0080669); autosomal dominant nonsyndromic deafness 28 (Disease Ontology:DOID:0110557)", "pathway": " (mmu:252973)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12175488;12393799;16831572;20654612;20978075;21081122;21750661;22696678;22955271;25428506;36852467;37364051;38300806;38833344", "class_list": "", "function": "A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele., [RefSeq, PubMed]; Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning., [RefSeq, PubMed]; Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse., [RefSeq, PubMed]; Grhl genes are highly expressed in the developing epidermis., [RefSeq, PubMed]; Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:22696678). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:20654612). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (PubMed:22696678). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia (PubMed:20978075). Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity. In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80UZ5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0060672 epithelial cell morphogenesis involved in placental branching;GO:0090132 epithelium migration;GO:0003208 cardiac ventricle morphogenesis;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K5C0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZR5-1", "uniprot_id": [ { "id": "SKI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZR5", "type": "external" } ], "mass": 137524.0, "length": 1244, "protein_name": "Superkiller complex protein 2", "gene_name": "Skic2", "organism": "Mouse", "refseq_name": "superkiller complex protein 2", "refseq_ac": [ { "id": "NP_067312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067312", "type": "external" } ], "gene_names_uniprotkb": "Skic2; Skiv2l", "gene_names_refseq": "4930534J06Rik; Ddx13; SKI; Ski2w; Ski2; Skic2; Skiv2l", "protein_names_uniprotkb": "Superkiller complex protein 2; 3.6.4.13; Ski2", "protein_names_refseq": "SKI2 subunit of superkiller complex protein; superkiller complex protein 2; superkiller viralicidic activity 2-like", "tax_id": 10090, "disease": "trichohepatoenteric syndrome 2 (Disease Ontology:DOID:0111416)", "pathway": " (mmu:108077); (R-MMU-429958)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW36", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0034458 3'-5' RNA helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0055087 Ski complex;GO:0005634 nucleus", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0000956 nuclear-transcribed mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NZR5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922M5-1", "uniprot_id": [ { "id": "CDA7L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922M5", "type": "external" } ], "mass": 50248.0, "length": 438, "protein_name": "Cell division cycle-associated 7-like protein", "gene_name": "Cdca7l", "organism": "Mouse", "refseq_name": "cell division cycle-associated 7-like protein isoform 3", "refseq_ac": [ { "id": "NP_666152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666152", "type": "external" } ], "gene_names_uniprotkb": "Cdca7l", "gene_names_refseq": "Cdca7l; JPO2", "protein_names_uniprotkb": "Cell division cycle-associated 7-like protein; Transcription factor RAM2", "protein_names_refseq": "cell division cycle-associated 7-like protein isoform 3; cell division cycle-associated 7-like protein; transcription factor RAM2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217946)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15994933;16829576;21183079;21750661;34428180;36893788", "class_list": "", "function": "E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription., [RefSeq, PubMed]; Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc., [RefSeq, PubMed]; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q922M5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZT5-1", "uniprot_id": [ { "id": "FGD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZT5", "type": "external" } ], "mass": 86541.0, "length": 766, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 4", "gene_name": "Fgd4", "organism": "Mouse", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha", "refseq_ac": [ { "id": "NP_001288747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288747", "type": "external" } ], "gene_names_uniprotkb": "Fgd4", "gene_names_refseq": "9030023J02Rik; 9330209B17Rik; Fgd4; Frabp; ZFYVE6", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 4; Actin filament-binding protein frabin; FGD1-related F-actin-binding protein", "protein_names_refseq": "FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha; FYVE, RhoGEF and PH domain-containing protein 4; Fgd1-related F-actin-binding protein; actin filament-binding protein frabin", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (mmu:224014); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10871857;11527409;11952837;17564959;21183079;21750661;25356636;30084848;35417030", "class_list": "", "function": "Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia., [UniProtKB, PubMed, PubMed]; Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4., [RefSeq, PubMed]; The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L355;Q3UEB6;Q8BW60;Q8BZI7;Q91ZT3;Q91ZT4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0031252 cell leading edge", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0046847 filopodium assembly;GO:0007010 cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0030035 microspike assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91ZT5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61490-1", "uniprot_id": [ { "id": "CD166_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61490", "type": "external" } ], "mass": 65092.0, "length": 583, "protein_name": "CD166 antigen", "gene_name": "Alcam", "organism": "Mouse", "refseq_name": "CD166 antigen isoform 1 precursor", "refseq_ac": [ { "id": "NP_033785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033785", "type": "external" } ], "gene_names_uniprotkb": "Alcam", "gene_names_refseq": "Alcam; BEN; CD166; DM-GRASP; MuSC; SC1", "protein_names_uniprotkb": "CD166 antigen; Activated leukocyte cell adhesion molecule; BEN; Protein DM-GRASP", "protein_names_refseq": "CD166 antigen isoform 1 precursor; CD166 antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:11658)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11801660;15345243;16075062;16914752;18250455;19656770;21750661;23169771;24740813;25730656;26495903;30084848;30899004;32152506;33300544;34428180;35820727;35984892;36210013;37828378;8089660;9209500", "class_list": "", "function": "Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:23169771). Required for normal organization of the lymph vessel network (PubMed:23169771). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow (PubMed:25730656). Promotes in vitro osteoblast proliferation and differentiation (PubMed:25730656). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (PubMed:15345243)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 25, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O70136;Q8CDA5;Q8R2T0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0042101 T cell receptor complex;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007155 cell adhesion;GO:0031175 neuron projection development;GO:0002250 adaptive immune response;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "Q61490-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X943-1", "uniprot_id": [ { "id": "S39A2_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X943", "type": "external" } ], "mass": 32236.0, "length": 309, "protein_name": "Zinc transporter ZIP2", "gene_name": "Slc39a2", "organism": "Mouse", "refseq_name": "zinc transporter ZIP2", "refseq_ac": [ { "id": "NP_001034765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034765", "type": "external" } ], "gene_names_uniprotkb": "Slc39a2; Zip2", "gene_names_refseq": "F730005G13Rik; Gm1789; Gm289; Slc39a2; ZIP-2; Zip2; hZIP2", "protein_names_uniprotkb": "Zinc transporter ZIP2; Solute carrier family 39 member 2; ZIP-2; Zrt- and Irt-like protein 2; hZIP2", "protein_names_refseq": "solute carrier family 39 member 2; zinc transporter ZIP2; zrt- and Irt-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:214922); (R-MMU-442380)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14525987;17506078;18353881;24936057;31095941;35296207", "class_list": "", "function": "Loss of Zip2 expression is associated with myocardial ischemia/reperfusion injury., [RefSeq, PubMed]; Results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes, [RefSeq, PubMed]; Slc39a2 apparently plays a critical role in zinc homeostasis when zinc is replete, but they play important, noncompensatory roles when this metal is deficient, [RefSeq, PubMed]; These studies suggest that active expression of the Zip2 gene in these few specific cell types, aforementioned, plays a particularly important role during zinc deficiency., [RefSeq, PubMed]; Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:14525987). The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (By similarity). In the skin, aids in the differentiation of keratinocytes in the epidermis (PubMed:24936057)., [UniProtKB, UniProtKB, PubMed, PubMed]; Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3., [RefSeq, PubMed]; ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HIZ9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0030216 keratinocyte differentiation;GO:0070574 cadmium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G3X943-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVE0-1", "uniprot_id": [ { "id": "AICDA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVE0", "type": "external" } ], "mass": 24031.0, "length": 198, "protein_name": "Single-stranded DNA cytosine deaminase", "gene_name": "Aicda", "organism": "Mouse", "refseq_name": "single-stranded DNA cytosine deaminase", "refseq_ac": [ { "id": "NP_033775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033775", "type": "external" } ], "gene_names_uniprotkb": "Aicda; Aid", "gene_names_refseq": "Aicda; Aid; Arp2", "protein_names_uniprotkb": "Single-stranded DNA cytosine deaminase; 3.5.4.38; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase", "protein_names_refseq": "activation induced deaminase; cytidine aminohydrolase; single-stranded DNA cytosine deaminase", "tax_id": 10090, "disease": "swine influenza (Disease Ontology:DOID:0050211); immunodeficiency with hyper-IgM type 2 (Disease Ontology:DOID:0060758); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); hyperimmunoglobulin syndrome (Disease Ontology:DOID:2959); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:11628)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10373455;11854365;11875397;12692563;18838546;19196992;19442251;20507984;21518874;21750661;23803409;25428506", "class_list": "", "function": "B cell stimulation which induces class switch recombination (CSR) but not somatic hypermutation (SHM), leads to AID-dependent accumulation of SHM-like point mutations in the switch mu region, uncoupled with CSR, [RefSeq, PubMed]; Ectopic expression of AID induces CSR in an artificial switch construct in fibroblasts at a level comparable to that in stimulated B cells, [RefSeq, PubMed]; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WVE0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98086-1", "uniprot_id": [ { "id": "C1QA_MOUSE", "url": "https://www.uniprot.org/uniprot/P98086", "type": "external" } ], "mass": 25974.0, "length": 245, "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1qa", "organism": "Mouse", "refseq_name": "complement C1q subcomponent subunit A precursor", "refseq_ac": [ { "id": "NP_031598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031598", "type": "external" } ], "gene_names_uniprotkb": "C1qa", "gene_names_refseq": "Adic; C1qa; C1q", "protein_names_uniprotkb": "Complement C1q subcomponent subunit A", "protein_names_refseq": "adiponectin c; complement C1q subcomponent subunit A precursor; complement C1q subcomponent subunit A", "tax_id": 10090, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12259); (R-MMU-173623); (R-MMU-977606)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16479539;16944957;1940381;26495903;26740625;30899004;33300544;34428180;8606057", "class_list": "", "function": "Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCM6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001774 microglial cell activation;GO:0016322 neuron remodeling;GO:0045087 innate immune response;GO:0048143 astrocyte activation;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P98086-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88874-1", "uniprot_id": [ { "id": "CCNK_MOUSE", "url": "https://www.uniprot.org/uniprot/O88874", "type": "external" } ], "mass": 61363.0, "length": 554, "protein_name": "Cyclin-K", "gene_name": "Ccnk", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccnk", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-K", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-112382); (R-MMU-2173796); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-75955)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "19144319;21183079;22012619;31219806;40997131;9632813", "class_list": "", "function": "Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QKT7;Q8R068", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0002944 cyclin K-CDK12 complex;GO:0002945 cyclin K-CDK13 complex;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88874-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARI4-1", "uniprot_id": [ { "id": "LGR4_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARI4", "type": "external" } ], "mass": 104150.0, "length": 951, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 4", "gene_name": "Lgr4", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing G-protein coupled receptor 4 precursor", "refseq_ac": [ { "id": "NP_766259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766259", "type": "external" } ], "gene_names_uniprotkb": "Lgr4; Gpr48", "gene_names_refseq": "9130225G07; A330106J01Rik; A930009A08Rik; Gpr48; Lgr4", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 4; G protein-coupled receptor 48", "protein_names_refseq": "G protein-coupled receptor GPR48; G-protein coupled receptor 48; leucine-rich repeat-containing G-protein coupled receptor 4 precursor", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:107515)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "12679517;15192078;16406039;16785743;17079737;17850793;18424556;18651655;18955481;19605502;20638054;21508962;21523854;21693646;21727895;23393138;23444378;23533175;23589304;24353284;29769720;32493844;37828378;38782937;39033139", "class_list": "", "function": "LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (PubMed:24353284). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (PubMed:32493844)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ARI3;Q6PHA3;Q80T31;Q8BXS9", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0008201 heparin binding;GO:0048495 Roundabout binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0045087 innate immune response;GO:0007623 circadian rhythm;GO:0046849 bone remodeling", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "A2ARI4-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97333-1", "uniprot_id": [ { "id": "NRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97333", "type": "external" } ], "mass": 103000.0, "length": 923, "protein_name": "Neuropilin-1", "gene_name": "Nrp1", "organism": "Mouse", "refseq_name": "neuropilin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032763", "type": "external" } ], "gene_names_uniprotkb": "Nrp1; Nrp", "gene_names_refseq": "C530029I03; NP-1; NPN-1; Npn1; Nrp1; Nrp", "protein_names_uniprotkb": "Neuropilin-1; A5 protein", "protein_names_refseq": "A5 protein; Neuropilin-1 precursor (A5 protein); neuropilin-1 isoform 1 precursor; transmembrane receptor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18186); (R-MMU-194306); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956); (R-MMU-445144)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;19656770;20133938;21183079;25605945;26503042;26789244;30084848;30623799;30899004;34428180;37507081;37828378;8748368", "class_list": "glycogene", "function": "Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 8, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAR3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0060980 cell migration involved in coronary vasculogenesis;GO:0097475 motor neuron migration;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P97333-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDS3-1", "uniprot_id": [ { "id": "SARM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDS3", "type": "external" } ], "mass": 79606.0, "length": 724, "protein_name": "NAD(+) hydrolase SARM1", "gene_name": "Sarm1", "organism": "Mouse", "refseq_name": "NAD(+) hydrolase SARM1 isoform 1", "refseq_ac": [ { "id": "NP_001161993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161993", "type": "external" } ], "gene_names_uniprotkb": "Sarm1; Kiaa0524", "gene_names_refseq": "A830091I15Rik; MyD885; Sarm1; Sarm", "protein_names_uniprotkb": "NAD(+) hydrolase SARM1; 3.2.2.-; 3.2.2.6; NADP(+) hydrolase SARM1; NADase SARM1; Sterile alpha and TIR motif-containing protein 1", "protein_names_refseq": "NAD(+) hydrolase SARM1 isoform 1; NAD(+) hydrolase SARM1; NADP(+) hydrolase SARM1; NADase SARM1; Tir-1 homolog; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:237868); (R-MMU-166166); (R-MMU-936964); (R-MMU-937041); (R-MMU-937072)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;17724133;18089857;19587044;21183079;21555400;21555464;22678360;22837513;25818290;26423149;26686637;26912636;27735788;27797810;28334607;28978465;29187734;31439642;32312889;32584865;33300544;34418053", "class_list": "", "function": "Burkholderia pseudomallei modulates macrophage defense mechanisms by upregulating SARM, thus leading to the suppression of IFN-beta and iNOS needed for bacterial elimination, [RefSeq, PubMed]; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25818290, PubMed:26686637, PubMed:27735788, PubMed:32312889). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:21555464, PubMed:22678360, PubMed:25818290, PubMed:26423149, PubMed:26686637). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:28334607). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (By similarity). Can activate neuronal cell death in response to stress (PubMed:19587044). Regulates dendritic arborization through the MAPK4-JNK pathway (PubMed:17724133, PubMed:21555464). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:21555464). Acts as a non-self dsDNA sensor in a sequence-independent manner to elicit NAD(+) degradation and thus to promote programmed cell death (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SARM functions to restrict viral infection and neuronal injury in a brain region-specific manner, possibly by modulating the activation of resident CNS inflammatory cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SYG5;Q5SYG6;Q6A054;Q6SZW0;Q8BRI9", "ec_number_list": [ { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0035591 signaling adaptor activity;GO:0003953 NAD+ nucleosidase activity;GO:0050135 NADP+ nucleosidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005874 microtubule", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0070585 protein localization to mitochondrion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q6PDS3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7T7-1", "uniprot_id": [ { "id": "CHADL_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7T7", "type": "external" } ], "mass": 81361.0, "length": 748, "protein_name": "Chondroadherin-like protein", "gene_name": "Chadl", "organism": "Mouse", "refseq_name": "chondroadherin-like protein precursor", "refseq_ac": [ { "id": "NP_001157792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157792", "type": "external" } ], "gene_names_uniprotkb": "Chadl; SLRR4B", "gene_names_refseq": "Chadl; D930017K21Rik", "protein_names_uniprotkb": "Chondroadherin-like protein", "protein_names_refseq": "chondroadherin pseudogene; chondroadherin-like protein precursor; chondroadherin-like protein; leucine rich repeat containing 15 pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:214685)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25451920;30899004;31219806", "class_list": "", "function": "Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0098633 collagen fibril binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0032331 negative regulation of chondrocyte differentiation;GO:1904027 negative regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9Q7T7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61922-1", "uniprot_id": [ { "id": "GABT_MOUSE", "url": "https://www.uniprot.org/uniprot/P61922", "type": "external" } ], "mass": 56452.0, "length": 500, "protein_name": "4-aminobutyrate aminotransferase, mitochondrial", "gene_name": "Abat", "organism": "Mouse", "refseq_name": "4-aminobutyrate aminotransferase, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_001164449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164449", "type": "external" } ], "gene_names_uniprotkb": "Abat; Gabat", "gene_names_refseq": "9630038C02Rik; Abat; Gabaat; Gabat; Gm9851; I54; Laibat", "protein_names_uniprotkb": "4-aminobutyrate aminotransferase, mitochondrial; (S)-3-amino-2-methylpropionate transaminase; 2.6.1.19; 2.6.1.22; GABA aminotransferase; GABA transaminase; GABA-AT; GABA-T; Gamma-amino-N-butyrate transaminase; L-AIBAT", "protein_names_refseq": "(S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase, mitochondrial isoform 2 precursor; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate transaminase; GABA aminotransferase; GABA transaminase; GABA transferase; beta-alanine oxoglutarate aminotransferase; gamma-amino-N-butyrate transaminase", "tax_id": 10090, "disease": "West syndrome (Disease Ontology:DOID:0050562); GABA aminotransferase deficiency (Disease Ontology:DOID:0060174); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); reflex epilepsy (Disease Ontology:DOID:2548); ischemia (Disease Ontology:DOID:326); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:268860); (R-MMU-916853)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;23576753;23806337;30084848;30662552;33300544;34428180;37453647", "class_list": "", "function": "Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine., [UniProtKB, UniProtKB]; The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]; These findings have provided underlying molecular details for the aggressive behavior of basal-like breast cancer (BLBC). The Snail-mediated downregulation of ABAT expression in BLBC provides tumorigenic and metastatic advantages by activating GABA-mediated Ca(2+)-NFAT1 axis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZA3", "ec_number_list": [ { "id": "2.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.19", "type": "external" }, { "id": "2.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.22", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding;GO:0032145 succinate-semialdehyde dehydrogenase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032144 4-aminobutyrate transaminase complex", "go_biological_process": "GO:0007626 locomotory behavior;GO:0032024 positive regulation of insulin secretion;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61922-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17665-1", "uniprot_id": [ { "id": "COX7C_MOUSE", "url": "https://www.uniprot.org/uniprot/P17665", "type": "external" } ], "mass": 7333.0, "length": 63, "protein_name": "Cytochrome c oxidase subunit 7C, mitochondrial", "gene_name": "Cox7c", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 7C, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031775", "type": "external" } ], "gene_names_uniprotkb": "Cox7c; Cox7c1", "gene_names_refseq": "COXVIIc; Cox7c1; Cox7c", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7C, mitochondrial; Cytochrome c oxidase polypeptide VIIc", "protein_names_refseq": "cytochrome c oxidase polypeptide VIIc; cytochrome c oxidase subunit 7C, mitochondrial precursor; cytochrome c oxidase subunit 7C, mitochondrial; cytochrome c oxidase subunit VIIc", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:12867); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "2163523;21750661;23576753;23806337;25428506;25605945;30084848;31219806;34428180;34616041;35820727;35833493;37453647;37828378;38575788", "class_list": "", "function": "Co-transport of the nuclear-encoded Cox7c mRNA with mitochondria along axons occurs through a coding-region-dependent mechanism., [RefSeq, PubMed]; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5S7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P17665-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19536-1", "uniprot_id": [ { "id": "COX5B_MOUSE", "url": "https://www.uniprot.org/uniprot/P19536", "type": "external" } ], "mass": 13813.0, "length": 128, "protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial", "gene_name": "Cox5b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cox5b", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase polypeptide Vb", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9837999); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "1651332;2169317;21750661;23576753;26495903;34428180;34616041;36288343;37453647;38575788;39927985", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043209 myelin sheath;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P19536-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X942-1", "uniprot_id": [ { "id": "G3X942_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X942", "type": "external" } ], "mass": 68707.0, "length": 604, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "Galnt9", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 9 isoform A", "refseq_ac": [ { "id": "NP_938048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938048", "type": "external" } ], "gene_names_uniprotkb": "Galnt9", "gene_names_refseq": "GalNAc-T9; Galnt9", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9; polypeptide N-acetylgalactosaminyltransferase 9 isoform A", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-913709)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30779550;31599954", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.8, "record_id": "G3X942-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKT3-1", "uniprot_id": [ { "id": "GCFC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKT3", "type": "external" } ], "mass": 87442.0, "length": 769, "protein_name": "Intron Large complex component GCFC2", "gene_name": "Gcfc2", "organism": "Mouse", "refseq_name": "intron Large complex component GCFC2", "refseq_ac": [ { "id": "NP_808552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808552", "type": "external" } ], "gene_names_uniprotkb": "Gcfc2; Gcf; Tcf9", "gene_names_refseq": "A130099G21; GCF2; Gcfc2; Tcf9", "protein_names_uniprotkb": "Intron Large complex component GCFC2; GC-rich sequence DNA-binding factor 2; GC-rich sequence DNA-binding factor; TCF-9; Transcription factor 9", "protein_names_refseq": "GCF; TCF-9; intron Large complex component GCFC2; transcription factor 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:330361); (R-MMU-72163)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15345747;21183079;21750661;30084848;31257544;34428180;35820727", "class_list": "", "function": "Involved in pre-mRNA splicing through regulating spliceosome C complex formation (By similarity). May play a role during late-stage splicing events and turnover of excised introns (By similarity)., [UniProtKB, UniProtKB]; The inhibition of vascular smooth muscle cells proliferation and migration by knockdown of GCF2 by RNA interference was mediated by the PI3K/AKT signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWF7;Q8BK44", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0071008 U2-type post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BKT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUR3-1", "uniprot_id": [ { "id": "FOXJ3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUR3", "type": "external" } ], "mass": 68954.0, "length": 623, "protein_name": "Forkhead box protein J3", "gene_name": "Foxj3", "organism": "Mouse", "refseq_name": "forkhead box protein J3 isoform 2", "refseq_ac": [ { "id": "NP_001277625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277625", "type": "external" } ], "gene_names_uniprotkb": "Foxj3; Kiaa1041", "gene_names_refseq": "C330039G02Rik; Fhd6; Foxj3", "protein_names_uniprotkb": "Forkhead box protein J3", "protein_names_refseq": "forkhead box protein J3 isoform 2; forkhead box protein J3; forkhead domain gene 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:230700)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "19914232;21183079;21750661;21952136;23047984;27739607;30084848;31219806;34203471;34428180;36210013;37939221", "class_list": "", "function": "FOXJ3 is required for the survival of spermatogonia and participates in spermatocyte meiosis., [RefSeq, PubMed]; Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1alpha., [RefSeq, PubMed]; Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (PubMed:19914232). Plays an important role in spermatogenesis (PubMed:27739607). Required for the survival of spermatogonia and participates in spermatocyte meiosis (PubMed:27739607)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AA37;A2AA38;Q3UTD8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BUR3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPZ9-1", "uniprot_id": [ { "id": "BICRA_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPZ9", "type": "external" } ], "mass": 161354.0, "length": 1578, "protein_name": "BRD4-interacting chromatin-remodeling complex-associated protein", "gene_name": "Bicra", "organism": "Mouse", "refseq_name": "BRD4-interacting chromatin-remodeling complex-associated protein", "refseq_ac": [ { "id": "NP_001074887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074887", "type": "external" } ], "gene_names_uniprotkb": "Bicra; Gltscr1", "gene_names_refseq": "Bicra; Gltscr1", "protein_names_uniprotkb": "BRD4-interacting chromatin-remodeling complex-associated protein; Glioma tumor suppressor candidate region gene 1 protein", "protein_names_refseq": "BRD4-interacting chromatin-remodeling complex-associated protein; glioma tumor suppressor candidate region gene 1 protein", "tax_id": 10090, "disease": "Coffin-Siris syndrome 12 (Disease Ontology:DOID:0112370); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (mmu:243842); (R-MMU-9933947)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "23806337;29374058;34418053;34678516;35820727;36745292;40885482;40997131", "class_list": "", "function": "Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (By similarity)., [UniProtKB, UniProtKB, PubMed]; Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Predicted gene 14692", "gene_name": "Gm14692", "organism": "Mouse", "refseq_name": "synaptonemal complex protein 3-like", "refseq_ac": [ { "id": "NP_001119789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119789", "type": "external" } ], "gene_names_uniprotkb": "Gm14692; Gm1140", "gene_names_refseq": "Gm1140", "protein_names_uniprotkb": "Predicted gene 1140; Predicted gene 14692", "protein_names_refseq": "synaptonemal complex protein 3-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:382217); (mmu:666842)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17660561;21750661", "class_list": "", "function": "Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BH01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KG45-1", "uniprot_id": [ { "id": "A3KG45_MOUSE", "url": "https://www.uniprot.org/uniprot/A3KG45", "type": "external" } ], "mass": 21802.0, "length": 208, "protein_name": "L antigen family member 3", "gene_name": "Ctag2l1", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC628456", "refseq_ac": [ { "id": "NP_001092775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092775", "type": "external" } ], "gene_names_uniprotkb": "Ctag2l1; Gm6880", "gene_names_refseq": "Ctag2l1; EG628456; Gm6880", "protein_names_uniprotkb": "L antigen family member 3", "protein_names_refseq": "uncharacterized protein LOC628456", "tax_id": 10090, "disease": "", "pathway": " (mmu:628456)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3KG45-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1ASY6-1", "uniprot_id": [ { "id": "B1ASY6_MOUSE", "url": "https://www.uniprot.org/uniprot/B1ASY6", "type": "external" } ], "mass": 33434.0, "length": 285, "protein_name": "Mitochondrial intermembrane space import and assembly protein 40", "gene_name": "AU015836", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AU015836", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial intermembrane space import and assembly protein 40; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1ASY6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RVW2-1", "uniprot_id": [ { "id": "CLRN2_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RVW2", "type": "external" } ], "mass": 25486.0, "length": 232, "protein_name": "Clarin-2", "gene_name": "Clrn2", "organism": "Mouse", "refseq_name": "clarin-2", "refseq_ac": [ { "id": "NP_001156789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156789", "type": "external" } ], "gene_names_uniprotkb": "Clrn2", "gene_names_refseq": "Clrn2; EG624224; mpc169H", "protein_names_uniprotkb": "Clarin-2", "protein_names_refseq": "clarin-2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (mmu:624224)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31448880;33496845;38243601", "class_list": "", "function": "Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss., [RefSeq, PubMed]; In the differentiating hair bundles, lack of clarin-2 leads to loss of mechano-electrical transduction, followed by selective progressive loss of the transducing stereocilia., [RefSeq, PubMed]; Plays a key role to hearing function. Required for normal organization and maintenance of the stereocilia bundle and for mechano-electrical transduction., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032421 stereocilium bundle;GO:0060171 stereocilium membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization;GO:0120045 stereocilium maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2RVW2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXA7-1", "uniprot_id": [ { "id": "CP26C_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXA7", "type": "external" } ], "mass": 57026.0, "length": 518, "protein_name": "Cytochrome P450 26C1", "gene_name": "Cyp26c1", "organism": "Mouse", "refseq_name": "cytochrome P450 26C1", "refseq_ac": [ { "id": "NP_001098671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098671", "type": "external" } ], "gene_names_uniprotkb": "Cyp26c1", "gene_names_refseq": "Cyp26c1; EG546726", "protein_names_uniprotkb": "Cytochrome P450 26C1; 1.14.14.1; Cyp26c1; Cytochrome P450, family 26, subfamily c, polypeptide 1", "protein_names_refseq": "cytochrome P450 26C1", "tax_id": 10090, "disease": "", "pathway": " (mmu:546726); (R-MMU-211916); (R-MMU-5365859)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12915310;15531370;15872003;15911617;17067568;31072004", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (Probable) (PubMed:15911617). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the oxidation of atRA primarily at C-4 (Probable). Oxidation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination, thereby contributes to the regulation of atRA homeostasis and signaling. Able to metabolize other RAs such as 9-cis with high efficiency (By similarity). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (Probable). Shares sequence similarity with other CYP26 family members, but has higher affinity to 9-cis-RA and is much less sensitive to the inhibitory effects of ketoconazole (By similarity). In cooperation with Cyp26a1, contributes to the CNS patterning and the development of regions of higher visual acuity (PubMed:15531370, PubMed:17067568)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Cyp26c1 degrades retinoic acid within the equatorial retina during later eye development., [RefSeq, PubMed]; Raldh2 and Cyp26 generate shifting boundaries of retionic acid activity, controlling hindbrain segmental gene expression., [RefSeq, PubMed]; We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0048284 organelle fusion;GO:0007417 central nervous system development;GO:0009952 anterior/posterior pattern specification;GO:0014032 neural crest cell development;GO:0034653 retinoic acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RXA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YWX5-1", "uniprot_id": [ { "id": "D3YWX5_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YWX5", "type": "external" } ], "mass": 27323.0, "length": 253, "protein_name": "Proline rich 23A, member 2", "gene_name": "Prr23a2", "organism": "Mouse", "refseq_name": "proline rich 23A, member 2", "refseq_ac": [ { "id": "NP_001128133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128133", "type": "external" } ], "gene_names_uniprotkb": "Prr23a2; 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Gm5895; Scgb1b11", "gene_names_refseq": "634929; Abpa20; EG545948; Gm5895; Gm7147; Scgb1b11; Scgb1b20", "protein_names_uniprotkb": "Secretoglobin, family 1B, member 20", "protein_names_refseq": "androgen-binding protein-like precursor; secretoglobin, family 1B, member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:545948)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005496 steroid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PWZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1ARD8-1", "uniprot_id": [ { "id": "SLFN8_MOUSE", "url": "https://www.uniprot.org/uniprot/B1ARD8", "type": "external" } ], "mass": 104264.0, "length": 910, "protein_name": "Schlafen family member 8", "gene_name": "Slfn8", "organism": "Mouse", "refseq_name": "schlafen family member 8 isoform 1", "refseq_ac": [ { "id": "NP_853523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853523", "type": "external" } ], "gene_names_uniprotkb": "Slfn8", "gene_names_refseq": "Slfn8; 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Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). May be involved in immune system via regulation of inflammation (PubMed:29528433)., [UniProtKB, PubMed, PubMed]; Functional participation of slfn8 in the regulatory networks governing T cell development and growth appears to be cell type specific, [RefSeq, PubMed]; Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response. Publication Status: Online-Only, [RefSeq, PubMed]; Several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8., [RefSeq, PubMed]; We demonstrated that Slfn8-/- mice were resistant to the development of EAE., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A0MQG0;F6RTS1;Q3UBN9;Q7TMF1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0000049 tRNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090734 site of DNA damage", "go_biological_process": "GO:0016078 tRNA decay;GO:0051607 defense response to virus;GO:0016075 rRNA catabolic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1ARD8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q252-1", "uniprot_id": [ { "id": "E9Q252_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q252", "type": "external" } ], "mass": 34497.0, "length": 308, "protein_name": "Olfactory receptor family 52 subfamily AC member 1", "gene_name": "Or52ac1", "organism": "Mouse", "refseq_name": "olfactory receptor 655", "refseq_ac": [ { "id": "NP_667031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667031", "type": "external" } ], "gene_names_uniprotkb": "Or52ac1; Olfr655", "gene_names_refseq": "MOR38-1; Olfr655; Or52ac1", "protein_names_uniprotkb": "Olfactory receptor family 52 subfamily AC member 1", "protein_names_refseq": "GA_x6K02T2PBJ9-7224628-7223702; olfactory receptor 655; olfactory receptor MOR38-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258817)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q252-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3K2-1", "uniprot_id": [ { "id": "E9Q3K2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3K2", "type": "external" } ], "mass": 35599.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or2t1", "organism": "Mouse", "refseq_name": "olfactory receptor 31", "refseq_ac": [ { "id": "NP_667238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667238", "type": "external" } ], "gene_names_uniprotkb": "Or2t1; Olfr31", "gene_names_refseq": "MOR274-1; MTPCR53; Olfr31; Or2t1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PLTE-6714644-6715597; olfactory receptor 31; olfactory receptor MOR274-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18330); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q3K2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9Z0-1", "uniprot_id": [ { "id": "E9Q9Z0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9Z0", "type": "external" } ], "mass": 34919.0, "length": 307, "protein_name": "Olfactory receptor", "gene_name": "Or11h23", "organism": "Mouse", "refseq_name": "olfactory receptor 748", "refseq_ac": [ { "id": "NP_001011837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011837", "type": "external" } ], "gene_names_uniprotkb": "Or11h23; Olfr748", "gene_names_refseq": "MOR106-9P; Olfr748; Or11h23", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PMLR-6454789-6455712; olfactory receptor 748; olfactory receptor MOR106-9P", "tax_id": 10090, "disease": "", "pathway": " (mmu:258113)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"https://www.ncbi.nlm.nih.gov/protein/NP_034002", "type": "external" } ], "gene_names_uniprotkb": "Cdk5r2; Nck5ai", "gene_names_refseq": "B230310J22Rik; Cdk5r2; p39", "protein_names_uniprotkb": "Cyclin-dependent kinase 5 activator 2; CDK5 activator 2; Cyclin-dependent kinase 5 regulatory subunit 2; p39I; p39", "protein_names_refseq": "CDK5 activator 2; cyclin-dependent kinase 5 activator 2; p39I", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:12570)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;28969475;33127972;35674931;38824254;9655938", "class_list": "", "function": "Activator of CDK5/TPKII., [UniProtKB]; P39 Affects Myelin Formation in Cerebral Ischemic Injury. Publication Status: Online-Only, [RefSeq, PubMed]; P39-associated Cdk5 activity regulates dendritic morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; That the knockout of p39 in mice did not affect orofacial and peripheral nociception, [RefSeq, PubMed]; Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35277;Q9QYD1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0008289 lipid binding;GO:0008092 cytoskeletal protein binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone;GO:0043005 neuron projection", "go_biological_process": "GO:0001764 neuron migration;GO:0021766 hippocampus development;GO:0045860 positive regulation of protein kinase activity;GO:0007420 brain development;GO:0021819 layer formation in cerebral cortex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35926-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51683-1", "uniprot_id": [ { "id": "CCR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P51683", "type": "external" } ], "mass": 42783.0, "length": 373, "protein_name": "C-C chemokine receptor type 2", "gene_name": "Ccr2", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 2", "refseq_ac": [ { "id": "NP_034045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034045", "type": "external" } ], "gene_names_uniprotkb": "Ccr2; Cmkbr2", "gene_names_refseq": "Cc-ckr-2; Ccr2a; Ccr2b; Ccr2; Ckr2a; Ckr2b; Ckr2; Cmkbr2; mJe-r", "protein_names_uniprotkb": "C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; JE/FIC receptor; MCP-1 receptor", "protein_names_refseq": "C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; C-C chemokine receptor type 2; CCR-2; JE/FIC receptor; MCP-1 receptor; MIP-1 alphaR; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Coronavirus infectious disease (Disease Ontology:DOID:0080599); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pleural tuberculosis (Disease Ontology:DOID:106); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sarcoidosis (Disease Ontology:DOID:11335); prediabetes syndrome (Disease Ontology:DOID:11716); posterior uveitis (Disease Ontology:DOID:12574); intermediate uveitis (Disease Ontology:DOID:12732); Kawasaki disease (Disease Ontology:DOID:13378); aggressive periodontitis (Disease Ontology:DOID:1474); urticaria (Disease Ontology:DOID:1555); fungal infectious disease (Disease Ontology:DOID:1564); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); demyelinating disease (Disease Ontology:DOID:3213); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); inclusion body myositis (Disease Ontology:DOID:3429); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); periapical periodontitis (Disease Ontology:DOID:823); lung disease (Disease Ontology:DOID:850); myeloid sarcoma (Disease Ontology:DOID:8683); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12772)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "24806994;28507030;29632244;29930553;29993042;34428180;8631787;8662823;8872898;8996246", "class_list": "", "function": "Key functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines (PubMed:8631787, PubMed:8662823, PubMed:8996246). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (PubMed:28507030). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (PubMed:29930553). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed:29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed:29993042). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (PubMed:24806994, PubMed:29632244)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61172", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0042802 identical protein binding;GO:0019955 cytokine binding;GO:0071791 chemokine (C-C motif) ligand 5 binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0002246 wound healing involved in inflammatory response;GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P51683-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGU5-1", "uniprot_id": [ { "id": "CCNY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGU5", "type": "external" } ], "mass": 39395.0, "length": 341, "protein_name": "Cyclin-Y", "gene_name": "Ccny", "organism": "Mouse", "refseq_name": "cyclin-Y", "refseq_ac": [ { "id": "NP_080760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080760", "type": "external" } ], "gene_names_uniprotkb": "Ccny; Cfp1", "gene_names_refseq": "1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik; Ccny", "protein_names_uniprotkb": "Cyclin-Y; Cyclin fold protein 1", "protein_names_refseq": "cyclin fold protein 1; cyclin-Y", "tax_id": 10090, "disease": "", "pathway": " (mmu:67974)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18630941;19144319;21183079;21750661;22184064;31599954;34428180;36434054", "class_list": "", "function": "CDK16 isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity., [RefSeq, PubMed]; Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway., [RefSeq, PubMed]; Positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway (By similarity). Recruits CDK16 to the plasma membrane (By similarity). Positive regulatory subunit of the cyclin-dependent kinase CDK16., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI87;Q9CYN5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0010508 positive regulation of autophagy;GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BGU5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWK4-1", "uniprot_id": [ { "id": "CD5L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWK4", "type": "external" } ], "mass": 38863.0, "length": 352, "protein_name": "CD5 antigen-like", "gene_name": "Cd5l", "organism": "Mouse", "refseq_name": "CD5 antigen-like precursor", "refseq_ac": [ { "id": "NP_033820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033820", "type": "external" } ], "gene_names_uniprotkb": "Cd5l; Aim; Api6", "gene_names_refseq": "1/6; AAC-11; AIM; Api6; CT2; Cd5l; Pdp; Sp-alpha; mAIM", "protein_names_uniprotkb": "CD5 antigen-like; Apoptosis inhibitor expressed by macrophages; Apoptosis inhibitory 6; SP-alpha; mAIM", "protein_names_refseq": "AIM/Spalpha; CD5 antigen-like precursor; CT-2; Pdp 1/6; apoptosis inhibitor 6; apoptosis inhibitor expressed by macrophages", "tax_id": 10090, "disease": "", "pathway": " (mmu:11801); (R-MMU-3000471)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10651944;16054063;20519120;21730133;22579686;23236605;23562157;26048980;26607793;26607794;26726878;30324136;37592330;38006711;38922694;9892623", "class_list": "", "function": "AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions., [RefSeq, PubMed]; Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD. Publication Status: Online-Only, [RefSeq, PubMed]; CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression., [RefSeq, PubMed]; Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis (PubMed:26048980). Able to inhibit lipid droplet size in adipocytes (PubMed:20519120, PubMed:22579686). Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA) (PubMed:20519120). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease (PubMed:21730133). Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC) (PubMed:22579686, PubMed:26607793). Acts as a key regulator of metabolic switch in T-helper Th17 cells (PubMed:26607793, PubMed:26607794). Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation (PubMed:26607793). CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes (PubMed:26607793). Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (PubMed:23562157). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:16054063, PubMed:9892623). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (By similarity). Promotes recovery from acute kidney injury (AKI) by accumulating on necrotic cell debris within the kidney proximal tubules following AKI and interacting with HAVCR1 expressed on the surface of injured kidney tubular epithelial cells (PubMed:26726878). This enhances HAVCR1-mediated phagocytosis of intraluminal necrotic debris and contributes to kidney tissue repair (PubMed:26726878). Also enhances necrotic debris uptake by kidney macrophages in a HAVCR1-independent manner (PubMed:26726878)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35300;O35301;Q3TXN5;Q505P6;Q91W05", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0006915 apoptotic process;GO:0002376 immune system process;GO:0030449 regulation of complement activation;GO:1903661 positive regulation of complement-dependent cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QWK4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25918-1", "uniprot_id": [ { "id": "CD19_MOUSE", "url": "https://www.uniprot.org/uniprot/P25918", "type": "external" } ], "mass": 60149.0, "length": 547, "protein_name": "B-lymphocyte antigen CD19", "gene_name": "Cd19", "organism": "Mouse", "refseq_name": "B-lymphocyte antigen CD19 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033974", "type": "external" } ], "gene_names_uniprotkb": "Cd19", "gene_names_refseq": "Cd19", "protein_names_uniprotkb": "B-lymphocyte antigen CD19; Differentiation antigen CD19", "protein_names_refseq": "B-lymphocyte antigen CD19 isoform 1 precursor; B-lymphocyte antigen CD19; differentiation antigen CD19", "tax_id": 10090, "disease": "common variable immunodeficiency 3 (Disease Ontology:DOID:0081146)", "pathway": " (mmu:12478); (R-MMU-1257604); (R-MMU-198933); (R-MMU-6811558); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "10933394;11120811;12387743;1370948;1375324;15378723;1714482;20101619;21183079;21750661;2472450;26495903;28011936;32152506;34428180;39627609;7542548;7543183;9317126;9382888", "class_list": "", "function": "Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:20101619, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:7542548, PubMed:7543183, PubMed:9317126). Required for normal differentiation of B-1 cells (PubMed:12387743, PubMed:7542548, PubMed:7543183). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:12387743, PubMed:7542548, PubMed:9317126). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:7542548, PubMed:7543183)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q542B2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002322 B cell proliferation involved in immune response;GO:0050853 B cell receptor signaling pathway;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P25918-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10300-1", "uniprot_id": [ { "id": "CD8B_MOUSE", "url": "https://www.uniprot.org/uniprot/P10300", "type": "external" } ], "mass": 24288.0, "length": 213, "protein_name": "T-cell surface glycoprotein CD8 beta chain", "gene_name": "Cd8b", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD8 beta chain precursor", "refseq_ac": [ { "id": "NP_033988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033988", "type": "external" } ], "gene_names_uniprotkb": "Cd8b; Cd8b1; Ly-3; Lyt-3; Lyt3", "gene_names_refseq": "Cd8b1; Cd8b; Ly-3; Ly-C; Lyt-3", "protein_names_uniprotkb": "T-cell surface glycoprotein CD8 beta chain; Lymphocyte antigen 3; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein Lyt-3", "protein_names_refseq": "CD8 antigen, beta chain 1; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 beta chain precursor; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3; lymphocyte antigen 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:12526); (R-MMU-198933)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12215456;16356863;18929574;19088062;2452747;2784466;3035575;3169881;31980555;3258885;34478713;3498943;8064243;8108731;8537123", "class_list": "", "function": "Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q31127;Q60966;Q61811", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10300-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07763-1", "uniprot_id": [ { "id": "CD244_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07763", "type": "external" } ], "mass": 44836.0, "length": 397, "protein_name": "Natural killer cell receptor 2B4", "gene_name": "Cd244", "organism": "Mouse", "refseq_name": "natural killer cell receptor 2B4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_061199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061199", "type": "external" } ], "gene_names_uniprotkb": "Cd244; 2b4; Cd244a; Nmrk", "gene_names_refseq": "2B4; C9.1; Cd244a; Cd244; F730046O15Rik; Ly90; NAIL; NKR2B4; Nmrk; SLAMF4", "protein_names_uniprotkb": "Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Non-MHC restricted killing associated; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4", "protein_names_refseq": "CD244 natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; SLAM family member 4; natural killer cell receptor 2B4 isoform 1 precursor; natural killer cell receptor 2B4; non-MHC restricted killing associated; signaling lymphocytic activation molecule 4", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:18106); (R-MMU-202733)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10941850;11739483;12734329;15169881;15850375;15905190;15998796;16127454;16425036;17950006;19648922;20962259;22683124;25643613;35061505;36153598;37583293;38386559;8228228;8326140;9841922", "class_list": "", "function": "2B4: A potential target in Staphylococcus aureus associated allergic inflammation., [RefSeq, PubMed]; A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-alpha and IFN-gamma production in dNK cells during Toxoplasma gondii infection. Publication Status: Online-Only, [RefSeq, PubMed]; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:12734329, PubMed:19648922, PubMed:20962259, PubMed:8326140). Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:15169881, PubMed:15998796, PubMed:22683124, PubMed:8326140). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (PubMed:15905190). Regulation of NK cell activity by adapters SH2D1B and SH2D1B2 is reported conflictingly (PubMed:16127454, PubMed:16425036). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (PubMed:11739483). Inhibits inflammatory responses in dendritic cells (DCs) (PubMed:25643613)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors., [RefSeq, PubMed]; Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O88654;Q3UV86;Q9JIE0", "ec_number_list": [], "go_molecular_function": "GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response;GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0001773 myeloid dendritic cell activation;GO:0002323 natural killer cell activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q07763-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z58-1", "uniprot_id": [ { "id": "CF132_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Z58", "type": "external" } ], "mass": 127881.0, "length": 1206, "protein_name": "Uncharacterized protein C6orf132 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C6orf132 homolog", "refseq_ac": [ { "id": "NP_663464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663464", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "AI661453", "protein_names_uniprotkb": "Uncharacterized protein C6orf132 homolog", "protein_names_refseq": "uncharacterized protein C6orf132 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:224833)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;24129315;25428506;30084848", "class_list": "", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8K108", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91Z58-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0F5-1", "uniprot_id": [ { "id": "CH25H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0F5", "type": "external" } ], "mass": 34672.0, "length": 298, "protein_name": "Cholesterol 25-hydroxylase", "gene_name": "Ch25h", "organism": "Mouse", "refseq_name": "cholesterol 25-hydroxylase", "refseq_ac": [ { "id": "NP_034020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034020", "type": "external" } ], "gene_names_uniprotkb": "Ch25h", "gene_names_refseq": "Ch25h; m25OH", "protein_names_uniprotkb": "Cholesterol 25-hydroxylase; 1.14.99.38; Cholesterol 25-monooxygenase; m25OH", "protein_names_refseq": "cholesterol 25-hydroxylase; cholesterol 25-monooxygenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:12642); (R-MMU-192105)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12543708;19502589;19805370;21263022;22999953;25428506;27802388;29033131;9852097", "class_list": "", "function": "Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:29033131, PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097). In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (PubMed:9852097). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (PubMed:29033131). Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Data show that The increased Ch25h expression was dependent on Toll-like receptor 4 signaling., [RefSeq, PubMed]; Deletion of the mouse cholesterol 25-hydroxylase gene caused an increase in serum IgA., [RefSeq, PubMed]; We found that expression of Ch25h is upregulated following L. monocytogenes infection, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUM6;Q8CHQ2", "ec_number_list": [ { "id": "1.14.99.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.38", "type": "external" } ], "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding;GO:0008395 steroid hydroxylase activity;GO:0001567 cholesterol 25-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0016126 sterol biosynthetic process;GO:0035754 B cell chemotaxis;GO:0034340 response to type I interferon;GO:1903914 negative regulation of fusion of virus membrane with host plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0F5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28659-1", "uniprot_id": [ { "id": "CELF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P28659", "type": "external" } ], "mass": 52107.0, "length": 486, "protein_name": "CUGBP Elav-like family member 1", "gene_name": "Celf1", "organism": "Mouse", "refseq_name": "CUGBP Elav-like family member 1 isoform 2", "refseq_ac": [ { "id": "NP_001231820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231820", "type": "external" } ], "gene_names_uniprotkb": "Celf1; Brunol2; Cugbp1; Cugbp", "gene_names_refseq": "1600010O03Rik; Brunol2; CUG-BP1; CUG-BP; CUGBP; Celf1; Cugbp1; D2Wsu101e; HNAB50; NAB50", "protein_names_uniprotkb": "CUGBP Elav-like family member 1; 50 kDa nuclear polyadenylated RNA-binding protein; Brain protein F41; Bruno-like protein 2; CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP1; Deadenylation factor CUG-BP; Deadenylation factor EDEN-BP; EDEN-BP homolog; Embryo deadenylation element-binding protein homolog; RNA-binding protein BRUNOL-2", "protein_names_refseq": "50 kDa nuclear polyadenylated RNA-binding protein; CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUGBP Elav-like family member 1 isoform 2; EDEN-BP homolog; RNA-binding protein BRUNOL-2; brain protein F41; bruno-like protein 2; deadenylation factor CUG-BP; deadenylation factor EDEN-BP; embryo deadenylation element-binding protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:13046)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10893231;11158314;11686919;11707455;15082764;15830352;16931514;17130239;21750661;25003008;25428506;33811692;34428180;36214222;37048143;37507081;40997131", "class_list": "", "function": "CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure., [RefSeq, PubMed]; High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology. Publication Status: Online-Only, [RefSeq, PubMed]; Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition (By similarity). Acts both as an activator and a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Promotes exclusion of exon 11 of the INSR pre-mRNA (By similarity). Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast (By similarity). Increases translation and controls the choice of translation initiation codon of CEBPB mRNA (By similarity). Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3 (By similarity). Mediates rapid cytoplasmic mRNA deadenylation (By similarity). Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation (By similarity). Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs) (By similarity). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA (By similarity). Binds to the 5'-region of CDKN1A and CEBPB mRNAs (By similarity). Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFW9;A2AFX0;A2AFX1;A2AFX2;Q3U0N2;Q3UP93;Q3UY22;Q8R532;Q99PE1;Q9CXE5;Q9EPJ8;Q9JI37", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0042835 BRE binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0021987 cerebral cortex development;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P28659-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPL5-1", "uniprot_id": [ { "id": "CK096_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPL5", "type": "external" } ], "mass": 26495.0, "length": 246, "protein_name": "Uncharacterized protein C11orf96 homolog", "gene_name": "Ag2; Gm13889", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf96 homolog", "refseq_ac": [ { "id": "NP_001138506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138506", "type": "external" } ], "gene_names_uniprotkb": "Ag2; Gm13889; Gm13889", "gene_names_refseq": "Ag2; Gm13889", "protein_names_uniprotkb": "Uncharacterized protein C11orf96 homolog; Protein Ag2 homolog", "protein_names_refseq": "protein Ag2 homolog; uncharacterized protein C11orf96 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:620695)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WRN5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UPL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXK9-1", "uniprot_id": [ { "id": "CLIC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXK9", "type": "external" } ], "mass": 28287.0, "length": 251, "protein_name": "Chloride intracellular channel protein 5", "gene_name": "Clic5", "organism": "Mouse", "refseq_name": "chloride intracellular channel protein 5", "refseq_ac": [ { "id": "NP_766209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766209", "type": "external" } ], "gene_names_uniprotkb": "Clic5", "gene_names_refseq": "5730531E12Rik; B330005L24; Clic5; Gm322; jbg; nmf318", "protein_names_uniprotkb": "Chloride intracellular channel protein 5; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC5", "protein_names_refseq": "chloride intracellular channel protein 5; glutaredoxin-like oxidoreductase CLIC5", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 103 (Disease Ontology:DOID:0110464); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:224796)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17021174;20055760;20335315;20357015;21750661;24285636;29425878;30084848;34428180;37952086", "class_list": "", "function": "CLIC5 associates with radixin in hair cell stereocilia and may help form or stabilize connections between the plasma membrane and the filamentous actin core., [RefSeq, PubMed]; CLIC5 disrupts proliferation of C2C12 cells and is involved in the differentiation of myoblasts by enhancing the protein expression level of MyHC, myogenin and desmin. Publication Status: Online-Only, [RefSeq, PubMed]; CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture., [RefSeq, PubMed]; Clic5 mutant mice are resistant to diet-induced obesity., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (By similarity). Required for normal hearing (By similarity). Necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (PubMed:17021174, PubMed:24285636). Required for the proper localization of PTPRQ and RDX to the stereocilium base during postnatal maturation of hair bundles (PubMed:24285636). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions (By similarity). Required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (PubMed:29425878)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0H8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0007601 visual perception;GO:0002024 diet induced thermogenesis;GO:0007605 sensory perception of sound;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BXK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K327-1", "uniprot_id": [ { "id": "CHAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K327", "type": "external" } ], "mass": 87561.0, "length": 802, "protein_name": "Chromosome alignment-maintaining phosphoprotein 1", "gene_name": "Champ1", "organism": "Mouse", "refseq_name": "chromosome alignment-maintaining phosphoprotein 1", "refseq_ac": [ { "id": "NP_862902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_862902", "type": "external" } ], "gene_names_uniprotkb": "Champ1; D8Ertd457e; Kiaa1802; Zfp828; Znf828", "gene_names_refseq": "Champ1; D8Ertd457e; D8Ertd569e; Zfp828; Znf828; mKIAA1802", "protein_names_uniprotkb": "Chromosome alignment-maintaining phosphoprotein 1; Zinc finger protein 828", "protein_names_refseq": "chromosome alignment-maintaining phosphoprotein 1; zinc finger protein 828", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 40 (Disease Ontology:DOID:0070070)", "pathway": " (mmu:101994)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;19131326;19144319;21183079;28528544;30059200;34428180;35820727", "class_list": "", "function": "Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ85;Q6ZPI1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0016604 nuclear body;GO:0000793 condensed chromosome", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0034501 protein localization to kinetochore;GO:0031134 sister chromatid biorientation;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K327-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3J5-1", "uniprot_id": [ { "id": "CHAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3J5", "type": "external" } ], "mass": 24547.0, "length": 223, "protein_name": "Glutathione-specific gamma-glutamylcyclotransferase 1", "gene_name": "Chac1", "organism": "Mouse", "refseq_name": "glutathione-specific gamma-glutamylcyclotransferase 1", "refseq_ac": [ { "id": "NP_081205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081205", "type": "external" } ], "gene_names_uniprotkb": "Chac1; Botch", "gene_names_refseq": "1810008K03Rik; Chac1", "protein_names_uniprotkb": "Glutathione-specific gamma-glutamylcyclotransferase 1; 4.3.2.7; Blocks Notch protein; Botch; Cation transport regulator-like protein 1; Gamma-GCG 1", "protein_names_refseq": "ChaC, cation transport regulator-like 1; blocks Notch protein; botch; cation transport regulator-like protein 1; gamma-GCG 1; glutathione-specific gamma-glutamylcyclotransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69065); (R-MMU-174403)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22445366;23070364;25428506;30084848;30779550;31219806;31599954;34428180;35820727;37014882", "class_list": "", "function": "CHAC1 inactivation is effective to preserve muscle glutathione but is insufficient to protect against muscle wasting in cachexia. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AV63;Q9D944", "ec_number_list": [ { "id": "4.3.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.7", "type": "external" } ], "go_molecular_function": "GO:0005112 Notch binding;GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0007219 Notch signaling pathway;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0022008 neurogenesis;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R3J5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA19-1", "uniprot_id": [ { "id": "CIR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA19", "type": "external" } ], "mass": 51838.0, "length": 450, "protein_name": "Corepressor of RBPJ and splicing regulator", "gene_name": "Cirsr", "organism": "Mouse", "refseq_name": "corepressor of RBPJ and splicing regulator", "refseq_ac": [ { "id": "NP_080130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080130", "type": "external" } ], "gene_names_uniprotkb": "Cirsr; Cir1; Cir", "gene_names_refseq": "1700023B02Rik; 2810021A19Rik; Cicr; Cir1; Cirsr; Cir", "protein_names_uniprotkb": "Corepressor of RBPJ and splicing regulator; CBF1-interacting corepressor; Corepressor interacting with RBPJ 1", "protein_names_refseq": "CBF1 interacting corepressor; corepressor interacting with RBPJ, 1; corepressor of RBPJ and splicing regulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:66935)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15652350;21183079;25428506;25875095", "class_list": "", "function": "Regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre-mRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2N9;Q4KL44;Q52KL9;Q5FW66", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DA19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0A1-1", "uniprot_id": [ { "id": "CLCN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0A1", "type": "external" } ], "mass": 99447.0, "length": 908, "protein_name": "Chloride channel protein 2", "gene_name": "Clcn2", "organism": "Mouse", "refseq_name": "chloride channel protein 2 isoform 1", "refseq_ac": [ { "id": "NP_034030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034030", "type": "external" } ], "gene_names_uniprotkb": "Clcn2; Clc2", "gene_names_refseq": "ClC-2; Clc2; Clcn2; nmf240", "protein_names_uniprotkb": "Chloride channel protein 2; ClC-2", "protein_names_refseq": "chloride channel 2; chloride channel protein 2 isoform 1; chloride channel protein 2", "tax_id": 10090, "disease": "leukodystrophy (Disease Ontology:DOID:10579); cystic fibrosis (Disease Ontology:DOID:1485); myopathy (Disease Ontology:DOID:423); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (mmu:12724); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10524221;16155254;17567819;18801913;20357128;21183079;21750661;22079595;22405205;25428506;26666914;29403011;29403012;30084848;30899004;31219806;32466489;34070744;34428180;35820727", "class_list": "", "function": "CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity (PubMed:18801913, PubMed:20357128, PubMed:26666914). Contributes to chloride conductance involved in neuron excitability. In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor activation. In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and potassium concentrations (PubMed:17567819, PubMed:20357128, PubMed:22405205). Regulates aldosterone production in adrenal glands. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity) (PubMed:29403012). Contributes to chloride conductance in retinal pigment epithelium involved in phagocytosis of shed photoreceptor outer segments and photoreceptor renewal (By similarity). Conducts chloride currents at the basolateral membrane of epithelial cells with a role in chloride reabsorption rather than secretion (By similarity) (PubMed:18801913, PubMed:22079595). Permeable to small monovalent anions with chloride > thiocyanate > bromide > nitrate > iodide ion selectivity (PubMed:26666914)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBC2;Q9WUJ9", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0017081 chloride channel regulator activity;GO:0005247 voltage-gated chloride channel activity;GO:0008308 voltage-gated monoatomic anion channel activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0043209 myelin sheath", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1902943 positive regulation of voltage-gated chloride channel activity;GO:0030322 stabilization of membrane potential;GO:0006911 phagocytosis, engulfment;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9R0A1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35454-1", "uniprot_id": [ { "id": "CLCN6_MOUSE", "url": "https://www.uniprot.org/uniprot/O35454", "type": "external" } ], "mass": 96980.0, "length": 870, "protein_name": "H(+)/Cl(-) exchange transporter 6", "gene_name": "Clcn6", "organism": "Mouse", "refseq_name": "H(+)/Cl(-) exchange transporter 6", "refseq_ac": [ { "id": "NP_036059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036059", "type": "external" } ], "gene_names_uniprotkb": "Clcn6; Clc6", "gene_names_refseq": "Clc6; Clcn6", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 6; Chloride channel protein 6; Chloride transport protein 6; ClC-6", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 6; chloride channel 6; chloride channel protein 6; chloride transport protein 6; clC-6", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 15 (Disease Ontology:DOID:0061189); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:26372); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16950870;21183079;21750661;22534482;33217309;34428180;9224655", "class_list": "", "function": "A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl(-)/H(+)-Exchanger, Causes Early-Onset Neurodegeneration., [RefSeq, PubMed]; This gene encodes a member of the ClC chloride channel and transporter family of proteins. The encoded protein may function as a vesicular Cl-/H+ antiporter. Homozygous knockout mice exhibit decreased pain sensitivity, behavioral abnormalities and features of lysosomal storage disease. [provided by RefSeq, Aug 2015]., [RefSeq]; This study demonistrated that clcn6 gene expression in mouse dorsal raphe nucleus, [RefSeq, PubMed]; Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0009612 response to mechanical stimulus;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35454-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88551-1", "uniprot_id": [ { "id": "CLD1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88551", "type": "external" } ], "mass": 22881.0, "length": 211, "protein_name": "Claudin-1", "gene_name": "Cldn1", "organism": "Mouse", "refseq_name": "claudin-1", "refseq_ac": [ { "id": "NP_057883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057883", "type": "external" } ], "gene_names_uniprotkb": "Cldn1", "gene_names_refseq": "Cldn1", "protein_names_uniprotkb": "Claudin-1", "protein_names_refseq": "claudin-1", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); atopic dermatitis (Disease Ontology:DOID:3310); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); periodontitis (Disease Ontology:DOID:824); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:12737)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10508613;10562289;10601346;11489913;11889141;12021270;23407391;30734065;9647647", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol;GO:0051259 protein complex oligomerization;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88551-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJY5-1", "uniprot_id": [ { "id": "COPD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XJY5", "type": "external" } ], "mass": 57229.0, "length": 511, "protein_name": "Coatomer subunit delta", "gene_name": "Arcn1", "organism": "Mouse", "refseq_name": "coatomer subunit delta", "refseq_ac": [ { "id": "NP_666097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666097", "type": "external" } ], "gene_names_uniprotkb": "Arcn1; Copd", "gene_names_refseq": "4632432M07Rik; Arcn1; nur17", "protein_names_uniprotkb": "Coatomer subunit delta; Archain; Delta-COP; Delta-coat protein", "protein_names_refseq": "coatomer subunit delta; delta-COP; delta-coat protein; pale coat neuro", "tax_id": 10090, "disease": "", "pathway": " (mmu:213827); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16476741;23806337;31219806;34428180;36210013;37453647;37507081", "class_list": "", "function": "NCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP, [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030137 COPI-coated vesicle;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5XJY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4M7-1", "uniprot_id": [ { "id": "CENPU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4M7", "type": "external" } ], "mass": 46370.0, "length": 410, "protein_name": "Centromere protein U", "gene_name": "Cenpu", "organism": "Mouse", "refseq_name": "centromere protein U isoform 1", "refseq_ac": [ { "id": "NP_082249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082249", "type": "external" } ], "gene_names_uniprotkb": "Cenpu; Mlf1ip", "gene_names_refseq": "1700029A22Rik; Cenpu; Mlf1ip", "protein_names_uniprotkb": "Centromere protein U; CENP-U; MLF1-interacting protein", "protein_names_refseq": "CENP-U; MLF1-interacting protein; centromere protein U isoform 1; myeloid leukemia factor 1 interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71876); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "15116101;21183079;21750661;23724000;28173615;31219806;32535988", "class_list": "", "function": "CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model., [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity)., [UniProtKB]; MLF1-IP expression at about 50% of its normal level is sufficient to sustain mice life and the development of their immune system without apparent abnormalities. Publication Status: Online-Only, [RefSeq, PubMed]; MLF1IP transgenic mice developed polycythemia vera (PV)-like symptoms based on the analysis of hematological features, suggesting that MLF1IP is partially involved in the pathogenesis of PV., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6UNA2;Q9D9U1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C4M7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIF7-1", "uniprot_id": [ { "id": "COPB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIF7", "type": "external" } ], "mass": 107066.0, "length": 953, "protein_name": "Coatomer subunit beta", "gene_name": "Copb1", "organism": "Mouse", "refseq_name": "coatomer subunit beta", "refseq_ac": [ { "id": "NP_203534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203534", "type": "external" } ], "gene_names_uniprotkb": "Copb1; Copb", "gene_names_refseq": "2610019B04Rik; Copb1", "protein_names_uniprotkb": "Coatomer subunit beta; Beta-COP; Beta-coat protein", "protein_names_refseq": "beta-COP; beta-coat protein; coatomer subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:70349); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;11441537;16476741;17698811;18250455;18299400;19067489;19587158;20173027;20484733;21952136;22645316;23806337;25428506;25605945;26740625;28528544;30084848;30779550;31219806;34203471;34428180;36210013;37453647;37507081;39627609;7593324", "class_list": "", "function": "Provides evidence for a microtubule-dependent, active axonal kappa opioid receptor mRNA-transport process that involves Copb1 and can stimulate localized translation, [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1 (By similarity). Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins in cortical neurons. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9Y4;Q3TT72;Q3U8G9;Q3UE02", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9JIF7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYB1-1", "uniprot_id": [ { "id": "CLIC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYB1", "type": "external" } ], "mass": 28729.0, "length": 253, "protein_name": "Chloride intracellular channel protein 4", "gene_name": "Clic4", "organism": "Mouse", "refseq_name": "chloride intracellular channel protein 4", "refseq_ac": [ { "id": "NP_038913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038913", "type": "external" } ], "gene_names_uniprotkb": "Clic4", "gene_names_refseq": "Clic4; D0Jmb3; TU-74; mc3s5; mtCLIC", "protein_names_uniprotkb": "Chloride intracellular channel protein 4; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC4; mc3s5/mtCLIC", "protein_names_refseq": "chloride intracellular channel 4 (mitochondrial); chloride intracellular channel protein 4; glutaredoxin-like oxidoreductase CLIC4; mc3s5/mtCLIC", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:29876)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10593946;11997498;12958156;17242355;17636002;19197003;26740625;34839533;35042858;35863434;37317855;37453647;37507081;37828378;39181373", "class_list": "", "function": "CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA., [RefSeq, PubMed]; Chloride intracellular channel 4 (CLIC4) expression profile in the mouse medial prefrontal cortex and its regulation by ethanol., [RefSeq, PubMed]; Chloride intracellular channel 4 blockade improves cognition in mice with Alzheimer's disease: CLIC4 protein expression and tau protein hyperphosphorylation., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MtCLIC is involved in mitochondrial membrane potential generation in mitochondrial DNA-depleted cells., [RefSeq, PubMed]; MtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53., [RefSeq, PubMed]; Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMG5", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0009566 fertilization;GO:0030336 negative regulation of cell migration;GO:0030216 keratinocyte differentiation;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QYB1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z262-1", "uniprot_id": [ { "id": "CLD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z262", "type": "external" } ], "mass": 23388.0, "length": 219, "protein_name": "Claudin-6", "gene_name": "Cldn6", "organism": "Mouse", "refseq_name": "claudin-6", "refseq_ac": [ { "id": "NP_061247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061247", "type": "external" } ], "gene_names_uniprotkb": "Cldn6", "gene_names_refseq": "Cldn6", "protein_names_uniprotkb": "Claudin-6; Skullin", "protein_names_refseq": "claudin-6; skullin; tight junction molecule claudin 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:54419)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10601346;36935496;39169280;9892664", "class_list": "", "function": "CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation. Publication Status: Online-Only, [RefSeq, PubMed]; CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0001618 virus receptor activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0070830 bicellular tight junction assembly;GO:0045216 cell-cell junction organization;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z262-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59108-1", "uniprot_id": [ { "id": "CPNE2_MOUSE", "url": "https://www.uniprot.org/uniprot/P59108", "type": "external" } ], "mass": 61036.0, "length": 548, "protein_name": "Copine-2", "gene_name": "Cpne2", "organism": "Mouse", "refseq_name": "copine-2", "refseq_ac": [ { "id": "NP_705727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705727", "type": "external" } ], "gene_names_uniprotkb": "Cpne2", "gene_names_refseq": "3322401K10Rik; Cpne2", "protein_names_uniprotkb": "Copine-2; Copine II", "protein_names_refseq": "copine-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234577)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21087455;21750661;26175110", "class_list": "", "function": "Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]., [RefSeq]; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties (PubMed:21087455, PubMed:26175110)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The second C2-domain of copine-2 is responsible for calcium-dependent membrane association., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1D7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59108-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23927-1", "uniprot_id": [ { "id": "CRYAB_MOUSE", "url": "https://www.uniprot.org/uniprot/P23927", "type": "external" } ], "mass": 20069.0, "length": 175, "protein_name": "Alpha-crystallin B chain", "gene_name": "Cryab", "organism": "Mouse", "refseq_name": "alpha-crystallin B chain", "refseq_ac": [ { "id": "NP_001276711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276711", "type": "external" } ], "gene_names_uniprotkb": "Cryab; Crya2", "gene_names_refseq": "Crya-2; Crya2; Cryab; HspB5; P23", "protein_names_uniprotkb": "Alpha-crystallin B chain; Alpha(B)-crystallin; P23", "protein_names_refseq": "alpha(B)-crystallin; alpha-crystallin B chain; crystallin, alpha 2; heat shock protein CryAB; heat shock protein HspB5", "tax_id": 10090, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); cataract 16 multiple types (Disease Ontology:DOID:0110250); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12955); (R-MMU-3371571)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10683514;10751411;1846673;19252088;19272359;19538478;21183079;21750661;2725488;27301331;30016717;30974319;31599954;31786107;33220080;36288343;37507081;38381471;40021952;7838723;9701032;9774459", "class_list": "", "function": "CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system., [RefSeq, PubMed]; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (PubMed:31786107)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the small heat-shock protein (HSP20) family. The encoded protein is a molecular chaperone that protects proteins against thermal denaturation and other stresses. This protein is a component of the eye lens, regulates lens differentiation and functions as a refractive element in the lens. This protein is a negative regulator of inflammation, has anti-apoptotic properties and also plays a role in the formation of muscular tissue. Mice lacking this gene exhibit worse experimental autoimmune encephalomyelitis and inflammation of the central nervous system compared to the wild type. In mouse models, this gene has a critical role in alleviating the pathology of the neurodegenerative Alexander disease. Mutations in the human gene are associated with myofibrillar myopathy 2, fatal infantile hypertonic myofibrillar myopathy, multiple types of cataract and dilated cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64325", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P23927-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40223-1", "uniprot_id": [ { "id": "CSF3R_MOUSE", "url": "https://www.uniprot.org/uniprot/P40223", "type": "external" } ], "mass": 93379.0, "length": 837, "protein_name": "Granulocyte colony-stimulating factor receptor", "gene_name": "Csf3r", "organism": "Mouse", "refseq_name": "granulocyte colony-stimulating factor receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_031808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031808", "type": "external" } ], "gene_names_uniprotkb": "Csf3r; Csfgr", "gene_names_refseq": "Cd114; Csf3r; Csfgr; G-CSF-R; G-CSFR", "protein_names_uniprotkb": "Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R", "protein_names_refseq": "G-CSF receptor; colony stimulating factor 3 receptor (granulocyte); granulocyte colony-stimulating factor receptor isoform 1 precursor; granulocyte colony-stimulating factor receptor", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); myelodysplastic syndrome (Disease Ontology:DOID:0050908); chronic neutrophilic leukemia (Disease Ontology:DOID:0080187); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); hereditary neutrophilia (Disease Ontology:DOID:0090120); severe congenital neutropenia 7 (Disease Ontology:DOID:0112129); neutropenia (Disease Ontology:DOID:1227); cystic fibrosis (Disease Ontology:DOID:1485); myeloproliferative neoplasm (Disease Ontology:DOID:2226); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:12986)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10537111;21029969;2158861;9187659", "class_list": "", "function": "Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A2A8Y3", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0051916 granulocyte colony-stimulating factor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0030666 endocytic vesicle membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0019221 cytokine-mediated signaling pathway;GO:0097186 amelogenesis;GO:0045637 regulation of myeloid cell differentiation;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40223-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPU2-1", "uniprot_id": [ { "id": "FARP1_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPU2", "type": "external" } ], "mass": 118875.0, "length": 1048, "protein_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1", "gene_name": "Farp1", "organism": "Mouse", "refseq_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_598843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598843", "type": "external" } ], "gene_names_uniprotkb": "Farp1", "gene_names_refseq": "Cdep; Farp1", "protein_names_uniprotkb": "FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF and pleckstrin domain-containing protein 1", "protein_names_refseq": "FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 1; FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived); FERM, RhoGEF and pleckstrin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223254); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9035034)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "17242355;19131326;21183079;21750661;23209303;28528544;31219806;34203471;34428180;34887587;36210013", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity)., [UniProtKB]; It was shown that Farp1 regulates dendritic filopodial dynamics in immature neurons. Later in development, Farp1 is postsynaptic and FARP1's 4.1 protein/ezrin/radixin/moesin domain binds SynCAM 1, assembling a synaptic complex., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "C4IXU2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0007416 synapse assembly;GO:0016601 Rac protein signal transduction;GO:0048813 dendrite morphogenesis;GO:0098974 postsynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "F8VPU2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPF4-1", "uniprot_id": [ { "id": "FMNL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPF4", "type": "external" } ], "mass": 117169.0, "length": 1028, "protein_name": "Formin-like protein 3", "gene_name": "Fmnl3", "organism": "Mouse", "refseq_name": "formin-like protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001297551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297551", "type": "external" } ], "gene_names_uniprotkb": "Fmnl3; Frl2; Kiaa2014", "gene_names_refseq": "2700073B04Rik; FBP11; Fmnl3; Wbp3; mKIAA2014", "protein_names_uniprotkb": "Formin-like protein 3", "protein_names_refseq": "WW domain binding protein 3; formin-like 3 protein; formin-like protein 3 isoform 2; formin-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22379); (R-MMU-5663220); (R-MMU-8980692); (R-MMU-9013106)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21148482;21183079;21750661;28327544;28852060;30084848;34428180;37507081", "class_list": "", "function": "Force generation in lamellipodia strongly depends on FMNL formin activity. Publication Status: Online-Only, [RefSeq, PubMed]; Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus. Erratum:[Sci Rep. 2019 Nov 26;9(1):18008. doi: 10.1038/s41598-019-54630-z. PMID: 31767955] Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignment., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCF9;Q3U2E4", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6ZPF4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3F5-1", "uniprot_id": [ { "id": "FABD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3F5", "type": "external" } ], "mass": 41928.0, "length": 381, "protein_name": "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial", "gene_name": "Mcat", "organism": "Mouse", "refseq_name": "malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001025185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025185", "type": "external" } ], "gene_names_uniprotkb": "Mcat; Mt", "gene_names_refseq": "Mcat", "protein_names_uniprotkb": "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; 2.3.1.39; MCT; Mitochondrial malonyltransferase; [Acyl-carrier-protein] malonyltransferase", "protein_names_refseq": "MCT; [Acyl-carrier-protein] malonyltransferase; malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 1; malonyl-CoA-acyl carrier protein transacylase, mitochondrial; mitochondrial malonyltransferase", "tax_id": 10090, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (mmu:223722); (R-MMU-77289)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23806337;31915829;36881526;37507081", "class_list": "", "function": "Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria., [UniProtKB, UniProtKB]; Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy., [RefSeq, PubMed]; Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZH0", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" } ], "go_molecular_function": "GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity;GO:0140691 RNA folding chaperone;GO:0016740 transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0180026 mitochondrial small ribosomal subunit assembly;GO:0032787 monocarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R3F5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50571-1", "uniprot_id": [ { "id": "GBRB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P50571", "type": "external" } ], "mass": 54100.0, "length": 474, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-1", "gene_name": "Gabrb1", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032095", "type": "external" } ], "gene_names_uniprotkb": "Gabrb1", "gene_names_refseq": "B230208N19Rik; Gabrb-1; Gabrb1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1; GABAAR subunit beta-1", "protein_names_refseq": "GABA(A) receptor subunit beta-1; GABAAR subunit beta-1; gamma-aminobutyric acid (GABA) A receptor, subunit beta 1; gamma-aminobutyric acid receptor subunit beta-1 isoform 1 precursor; gamma-aminobutyric acid receptor subunit beta-1", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); developmental and epileptic encephalopathy 45 (Disease Ontology:DOID:0080428); autistic disorder (Disease Ontology:DOID:12849); hepatic encephalopathy (Disease Ontology:DOID:13413); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:14400); (R-MMU-977443)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11528422;21750661;33300544;7893750", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0005253 monoatomic anion channel activity;GO:0050811 GABA receptor binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0032570 response to progesterone;GO:0009636 response to toxic substance;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P50571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCD6-1", "uniprot_id": [ { "id": "GBRAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCD6", "type": "external" } ], "mass": 13918.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein", "gene_name": "Gabarap", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor-associated protein", "refseq_ac": [ { "id": "NP_062723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062723", "type": "external" } ], "gene_names_uniprotkb": "Gabarap", "gene_names_refseq": "Gabarap", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein", "protein_names_refseq": "GABA-A receptor-associated protein; gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:56486); (R-MMU-1632852); (R-MMU-8854214)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10899939;10900017;11890701;14530254;18322192;21383079;21750661;24089209;26495903;26776506;33591943;33795848;34428180;34854256;37434364;37828378;8746565", "class_list": "", "function": "ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1., [RefSeq, PubMed]; GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway., [RefSeq, PubMed]; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis. Participates in selective ER-phagy through interaction with UBAC2, promoting recruitment of UBAC2-associated ER fragments to autophagosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AR49;Q9QUI7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding;GO:0048487 beta-tubulin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005790 smooth endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0000226 microtubule cytoskeleton organization;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9DCD6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4C1-1", "uniprot_id": [ { "id": "GASP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4C1", "type": "external" } ], "mass": 151745.0, "length": 1347, "protein_name": "G protein-coupled receptor-associated sorting protein 1", "gene_name": "Gprasp1", "organism": "Mouse", "refseq_name": "G-protein coupled receptor-associated sorting protein 1", "refseq_ac": [ { "id": "NP_001004359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004359", "type": "external" } ], "gene_names_uniprotkb": "Gprasp1; Kiaa0443", "gene_names_refseq": "2210415K24Rik; 3110031O14Rik; GASP1; GASP; Gprasp1", "protein_names_uniprotkb": "G protein-coupled receptor-associated sorting protein 1; GASP-1", "protein_names_refseq": "G-protein coupled receptor-associated sorting protein 1; GASP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67298)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15086532;21091868;21183079;22872234;23046573;23954414;30084848;32027737;34203471;34428180;37787182", "class_list": "", "function": "GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation., [RefSeq, PubMed]; GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals., [RefSeq, PubMed]; Modulates lysosomal sorting and functional down-regulation of a variety of G protein-coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2., [UniProtKB, PubMed]; Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life. Publication Status: Online-Only, [RefSeq, PubMed]; The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR)s in acquisition/expression of skilled behavior and motivation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AGB6;Q8BKR8;Q8BUN4;Q8BYK9;Q8CHF4;Q8R095", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:1990172 G protein-coupled receptor catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5U4C1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W43-1", "uniprot_id": [ { "id": "GCSP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W43", "type": "external" } ], "mass": 113267.0, "length": 1025, "protein_name": "Glycine dehydrogenase (decarboxylating), mitochondrial", "gene_name": "Gldc", "organism": "Mouse", "refseq_name": "glycine dehydrogenase (decarboxylating), mitochondrial precursor", "refseq_ac": [ { "id": "NP_613061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613061", "type": "external" } ], "gene_names_uniprotkb": "Gldc", "gene_names_refseq": "D030049L12Rik; D19Wsu57e; Gldc; b2b2679Clo", "protein_names_uniprotkb": "Glycine dehydrogenase (decarboxylating), mitochondrial; 1.4.4.2; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring)", "protein_names_refseq": "glycine cleavage system P protein; glycine dehydrogenase (aminomethyl-transferring); glycine dehydrogenase (decarboxylating), mitochondrial precursor; glycine dehydrogenase (decarboxylating), mitochondrial; glycine dehydrogenase [decarboxylating], mitochondrial", "tax_id": 10090, "disease": "glycine encephalopathy 1 (Disease Ontology:DOID:0070616); stomach cancer (Disease Ontology:DOID:10534); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (mmu:104174); (R-MMU-6783984)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17510459;23576753;25428506;30084848;34428180;37453647", "class_list": "", "function": "Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system., [RefSeq, PubMed]; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.4.2", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0016829 lyase activity;GO:0004375 glycine dehydrogenase (decarboxylating) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0019464 glycine decarboxylation via glycine cleavage system;GO:0006546 glycine catabolic process;GO:0036255 response to methylamine;GO:1903442 response to lipoic acid", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91W43-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80SY4-1", "uniprot_id": [ { "id": "MIB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80SY4", "type": "external" } ], "mass": 110088.0, "length": 1006, "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "Mib1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MIB1", "refseq_ac": [ { "id": "NP_659109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659109", "type": "external" } ], "gene_names_uniprotkb": "Mib1; Dip1; Kiaa1323; Mib", "gene_names_refseq": "DIP-1; E430019M12Rik; Mib1; Mib; mindbomb", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MIB1; 2.3.2.27; DAPK-interacting protein 1; DIP-1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1", "protein_names_refseq": "DAPK-interacting protein-1; E3 ubiquitin-protein ligase MIB1; RING-type E3 ubiquitin transferase MIB1; mind bomb homolog 1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; skeletrophin", "tax_id": 10090, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:225164)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12351649;12530964;15824097;16000382;16061358;18250455;21750661;22872234;25428506;26495903;27802388;28011936;30084848;30779550;34428180;35820727;36210013;37828378", "class_list": "", "function": "A targeted mutation of Mib1 in mice results in embryonic lethality;MIB1 activity is required for S3 cleavage of the Notch1 receptor., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis., [UniProtKB, PubMed]; Mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XK51;Q6IS57;Q6YI52;Q6ZPT8;Q8BNR1;Q8C6W2;Q921Q1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0007507 heart development;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q80SY4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1Z5-1", "uniprot_id": [ { "id": "GPSM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1Z5", "type": "external" } ], "mass": 17619.0, "length": 159, "protein_name": "G protein-signaling modulator 3", "gene_name": "Gpsm3", "organism": "Mouse", "refseq_name": "G-protein-signaling modulator 3", "refseq_ac": [ { "id": "NP_598877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877", "type": "external" } ], "gene_names_uniprotkb": "Gpsm3", "gene_names_refseq": "AGS4; Gpsm3", "protein_names_uniprotkb": "G protein-signaling modulator 3", "protein_names_refseq": "G-protein-signaling modulator 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:106512); (R-MMU-418594)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19144319;20097748;21750661;23280397;25271165;26495903;27802388;31219806", "class_list": "", "function": "Findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function., [RefSeq, PubMed]; GPSM3 is an important regulator of monocyte function involving mechanisms of differentiation, survival, and chemotaxis, and deficiency in GPSM3 expression is protective in acute inflammatory arthritis., [RefSeq, PubMed]; Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins., [UniProtKB]; The N-terminal region of G18 is a novel G protein-interacting domain that may have distinct regulatory effects within the G(i/o) subfamily, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1M8;Q3UJZ5;Q8VDF9", "ec_number_list": [], "go_molecular_function": "GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0050729 positive regulation of inflammatory response;GO:0002690 positive regulation of leukocyte chemotaxis;GO:1900017 positive regulation of cytokine production involved in inflammatory response;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U1Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0QWR4-1", "uniprot_id": [ { "id": "M0QWR4_MOUSE", "url": "https://www.uniprot.org/uniprot/M0QWR4", "type": "external" } ], "mass": 29516.0, "length": 261, "protein_name": "Aly/REF export factor family member 11; Aly/REF export factor family member 13; Aly/REF export factor family member 14; Aly/REF export factor family member 15; Aly/REF export factor family member 16; Aly/REF export factor family member 17", "gene_name": "Alyreffm17", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Alyreffm17; Alyreffm11; Alyreffm13; Alyreffm14; Alyreffm15; Alyreffm16; Gm20765; Gm21293; Gm21304; Gm21312; Gm6763; Gm8764", "gene_names_refseq": "", "protein_names_uniprotkb": "Aly/REF export factor family member 11; Aly/REF export factor family member 13; Aly/REF export factor family member 14; Aly/REF export factor family member 15; Aly/REF export factor family member 16; Aly/REF export factor family member 17", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0QWB2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006406 mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0QWR4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45591-1", "uniprot_id": [ { "id": "COF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P45591", "type": "external" } ], "mass": 18710.0, "length": 166, "protein_name": "Cofilin-2", "gene_name": "Cfl2", "organism": "Mouse", "refseq_name": "cofilin-2", "refseq_ac": [ { "id": "NP_031714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031714", "type": "external" } ], "gene_names_uniprotkb": "Cfl2", "gene_names_refseq": "Cfl2", "protein_names_uniprotkb": "Cofilin-2; Cofilin, muscle isoform", "protein_names_refseq": "cofilin-2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:12632)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11809832;16452087;19131326;21750661;22343409;24598388;31599954;33187645;34428180;34685705;36288343;36450139;37507081;39927985;8195165", "class_list": "", "function": "CFL2 is an essential mediator for myogenic differentiation in C2C12 myoblasts., [RefSeq, PubMed]; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere., [UniProtKB, PubMed, PubMed, PubMed]; LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Role of MiR-325-3p in the Regulation of CFL2 and Myogenic Differentiation of C2C12 Myoblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016363 nuclear matrix;GO:0031674 I band;GO:0030018 Z disc", "go_biological_process": "GO:0007015 actin filament organization;GO:0046716 muscle cell cellular homeostasis;GO:0045214 sarcomere organization;GO:0051014 actin filament severing;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P45591-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97468-1", "uniprot_id": [ { "id": "CML1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97468", "type": "external" } ], "mass": 41815.0, "length": 371, "protein_name": "Chemerin-like receptor 1", "gene_name": "Cmklr1", "organism": "Mouse", "refseq_name": "chemerin-like receptor 1", "refseq_ac": [ { "id": "NP_032179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032179", "type": "external" } ], "gene_names_uniprotkb": "Cmklr1; Dez; Gpcr27", "gene_names_refseq": "ChemR23; Cmklr1; DEZ; Gpcr27; mcmklr1", "protein_names_uniprotkb": "Chemerin-like receptor 1; Chemokine-like receptor 1; G protein-coupled receptor DEZ", "protein_names_refseq": "G-protein coupled receptor 27; G-protein coupled receptor DEZ; chemerin receptor; chemerin-like receptor 1; chemokine receptor-like 1; chemokine-like receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14747); (R-MMU-373076)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "15019996;15753205;16863918;17635925;17767914;18242188;19841182;21183079;21750661;25428506;37800344;38178174;38532043;9144535", "class_list": "", "function": "ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism., [UniProtKB, PubMed, PubMed, PubMed]; Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice., [RefSeq, PubMed]; Results provide a necessary basis for further studies of the gene regulation and function of this chemoattractant-like receptor and will be useful when manipulating the gene in the development of transgenic animal models., [RefSeq, PubMed]; The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0097003 adipokinetic hormone receptor activity;GO:0097004 adipokinetic hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P97468-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08791-1", "uniprot_id": [ { "id": "COE3_MOUSE", "url": "https://www.uniprot.org/uniprot/O08791", "type": "external" } ], "mass": 64878.0, "length": 596, "protein_name": "Transcription factor COE3", "gene_name": "Ebf3", "organism": "Mouse", "refseq_name": "transcription factor COE3 isoform 1", "refseq_ac": [ { "id": "NP_001106886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106886", "type": "external" } ], "gene_names_uniprotkb": "Ebf3; Coe3", "gene_names_refseq": "3110018A08Rik; Ebf3; O/E-2; mKIAA4201", "protein_names_uniprotkb": "Transcription factor COE3; EBF-3; Early B-cell factor 3; O/E-2; OE-2; Olf-1/EBF-like 2", "protein_names_refseq": "EBF-3; OE-2; Olf-1/EBF-like 2; transcription factor COE3 isoform 1; transcription factor COE3", "tax_id": 10090, "disease": "hypotonia, ataxia, and delayed development syndrome (Disease Ontology:DOID:0081176)", "pathway": " (mmu:13593)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;9151732;9389446", "class_list": "", "function": "Transcriptional activator (PubMed:9151732). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08793", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08791-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q793-1", "uniprot_id": [ { "id": "JHY_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q793", "type": "external" } ], "mass": 87417.0, "length": 770, "protein_name": "Jhy protein", "gene_name": "Jhy", "organism": "Mouse", "refseq_name": "jhy protein isoform b", "refseq_ac": [ { "id": "NP_001074590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074590", "type": "external" } ], "gene_names_uniprotkb": "Jhy", "gene_names_refseq": "4931429I11Rik; Jhy", "protein_names_uniprotkb": "Jhy protein; Juvenile hydrocephalus protein", "protein_names_refseq": "jhy protein isoform b; juvenile hydrocephalus protein; uncharacterized protein C11orf63 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70989)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23906841;29211732", "class_list": "", "function": "Juvenile hydrocephalus transgenic mice (Jhy(lacZ)) inherit communicating hydrocephalus in an autosomal recessive fashion with dilation of the lateral ventricles., [RefSeq, PubMed]; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces., [UniProtKB, PubMed]; Work shows that JHY does not only control ciliogenesis, but is a crucial component of the ependymal differentiation process, with ciliary defects likely a consequence of altered ependymal differentiation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0CX29;Q9CUE4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0007420 brain development;GO:0044458 motile cilium assembly;GO:0035082 axoneme assembly;GO:0090175 regulation of establishment of planar polarity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q793-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26339-1", "uniprot_id": [ { "id": "CMGA_MOUSE", "url": "https://www.uniprot.org/uniprot/P26339", "type": "external" } ], "mass": 51789.0, "length": 463, "protein_name": "Chromogranin-A", "gene_name": "Chga", "organism": "Mouse", "refseq_name": "chromogranin-A preproprotein", "refseq_ac": [ { "id": "NP_031719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031719", "type": "external" } ], "gene_names_uniprotkb": "Chga", "gene_names_refseq": "Chga; ChrA; cgA", "protein_names_uniprotkb": "Chromogranin-A; AL26; CgA", "protein_names_refseq": "chromogranin-A preproprotein", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:12652); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "12388744;18322192;20139986;2071596;21183079;21357258;21436258;21537909;22912420;22971988;23894487;24443235;25333865;25958206;26209627;26453556;27185276;31806623;32152506;33151102;34203471;34428180", "class_list": "glycogene", "function": "Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines., [UniProtKB, UniProtKB]; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258). Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress (PubMed:21537909)., [UniProtKB, PubMed, PubMed]; Strongly inhibits glucose induced insulin release from the pancreas., [UniProtKB]; This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0048471 perinuclear region of cytoplasm;GO:0030133 transport vesicle", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045907 positive regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P26339-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SJQ0-1", "uniprot_id": [ { "id": "CLM8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6SJQ0", "type": "external" } ], "mass": 35629.0, "length": 318, "protein_name": "CMRF35-like molecule 8", "gene_name": "Cd300a", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 8 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001334583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334583", "type": "external" } ], "gene_names_uniprotkb": "Cd300a; Clm8; Lmir1; Mcpir1", "gene_names_refseq": "B230315M08Rik; Cd300a; Clm8; LMIR1; MAIR-1; MAIR-Ia; MAIR-I; MMAC8; Pigr4; mcpir1", "protein_names_uniprotkb": "CMRF35-like molecule 8; CD300 antigen-like family member A; CLM-8; Leukocyte mono-Ig-like receptor 1; MAIR-1; MAIR-I; Mast cell-derived paired immunoglobulin-like receptor 1; Myeloid-associated immunoglobulin-like receptor 1", "protein_names_refseq": "CD300 antigen-like family member A; CD300A antigen; CMRF35-like molecule 8 isoform 2 precursor; CMRF35-like molecule 8; leukocyte mono-Ig-like receptor 1; mast cell-derived paired immunoglobulin-like receptor 1; myeloid-associated immunoglobulin-like receptor 1; polymeric immunoglobulin receptor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:217303)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12874256;12893283;14662855;16339535;19144319;26495903;34652960;34751648;36928079", "class_list": "", "function": "CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation., [RefSeq, PubMed]; CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke., [RefSeq, PubMed]; In a murine model of allergic peritonitis, neutralization of the murine homolog of IRp60, LMIR1, led to a significantly augmented release of inflammatory mediators and eosinophilic infiltration., [RefSeq, PubMed]; Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:12874256, PubMed:12893283, PubMed:16339535). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Molecular cloning and characterization of leukocyte mono-immunoglobulin-like receptor1 and 2 derived from mast cells [LMIR1] [LMIR2], [RefSeq, PubMed]; Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EIB1;Q7TN56;Q7TSN3;Q8CFN3", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008429 phosphatidylethanolamine binding;GO:0001786 phosphatidylserine binding;GO:0019902 phosphatase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0014063 negative regulation of serotonin secretion;GO:0048147 negative regulation of fibroblast proliferation;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6SJQ0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4N0-1", "uniprot_id": [ { "id": "CLYBL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4N0", "type": "external" } ], "mass": 37549.0, "length": 338, "protein_name": "Citramalyl-CoA lyase, mitochondrial", "gene_name": "Clybl", "organism": "Mouse", "refseq_name": "citramalyl-CoA lyase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_083832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083832", "type": "external" } ], "gene_names_uniprotkb": "Clybl; Clb", "gene_names_refseq": "0610033J05Rik; 2310014M14Rik; Clb; Clybl", "protein_names_uniprotkb": "Citramalyl-CoA lyase, mitochondrial; (3S)-malyl-CoA thioesterase; 2.3.3.-; 2.3.3.9; 3.1.2.30; 4.1.3.25; Beta-methylmalate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like protein, mitochondrial; Malate synthase", "protein_names_refseq": "(3S)-malyl-CoA thioesterase; beta-methylmalate synthase; citramalyl-CoA lyase, mitochondrial precursor; citramalyl-CoA lyase, mitochondrial; citrate lyase subunit beta-like protein, mitochondrial; malate synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:69634)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11741334;18614015;23576753;23806337;24334609;29056341;36288343;37507081;39927985", "class_list": "", "function": "Mitochondrial enzyme required to detoxify vitamin B12-poisoning metabolites (PubMed:29056341). Acts as a citramalyl-CoA lyase by converting citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway, a pathway required to detoxify itaconate, a vitamin B12-poisoning metabolite (By similarity). Also acts as a malyl-CoA thioesterase to detoxify malyl-CoA, a side product of citric acid cycle enzymes, which is toxic for the vitamin B12-dependent enzyme MMUT (By similarity). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (By similarity). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (By similarity). Also has very weak citramalate synthase activity in vitro (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7D0", "ec_number_list": [ { "id": "2.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.-", "type": "external" }, { "id": "2.3.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.9", "type": "external" }, { "id": "4.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.25", "type": "external" }, { "id": "3.1.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.30", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016289 acyl-CoA hydrolase activity;GO:0004474 malate synthase activity;GO:0047777 (S)-citramalyl-CoA lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070207 protein homotrimerization;GO:0106064 regulation of cobalamin metabolic process;GO:0106121 positive regulation of cobalamin metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R4N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0S3-1", "uniprot_id": [ { "id": "CLD14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0S3", "type": "external" } ], "mass": 25614.0, "length": 239, "protein_name": "Claudin-14", "gene_name": "Cldn14", "organism": "Mouse", "refseq_name": "claudin-14", "refseq_ac": [ { "id": "NP_001159397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159397", "type": "external" } ], "gene_names_uniprotkb": "Cldn14", "gene_names_refseq": "Cldn14", "protein_names_uniprotkb": "Claudin-14", "protein_names_refseq": "claudin-14", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 29 (Disease Ontology:DOID:0110487)", "pathway": " (mmu:56173)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11163249;12913076;18663477;21750661;32251970;33283646;39162877", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Diabetes compromises tight junction protein claudin 14 in the urinary bladder., [RefSeq, PubMed]; Localization and regulation of claudin-14 in experimental models of hypercalcemia., [RefSeq, PubMed]; Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice., [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]., [RefSeq]; To explore the role of claudin 14 in the inner ear and in other tissues we created a mouse model by a targeted deletion of Cldn14., [RefSeq, PubMed]; We generated claudin 11/claudin 14 double-deficient mice, which exhibit deafness, neurological deficits, and male sterility. Kidney function and ion balance are not significantly affected., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D284", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0S3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TRP9-1", "uniprot_id": [ { "id": "Q7TRP9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TRP9", "type": "external" } ], "mass": 36756.0, "length": 324, "protein_name": "Olfactory receptor family 52 subfamily U member 1", "gene_name": "Or52u1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or52u1; Olfr654", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor family 52 subfamily U member 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258377)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TRP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60994-1", "uniprot_id": [ { "id": "ADIPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60994", "type": "external" } ], "mass": 26809.0, "length": 247, "protein_name": "Adiponectin", "gene_name": "Adipoq", "organism": "Mouse", "refseq_name": "adiponectin precursor", "refseq_ac": [ { "id": "NP_033735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033735", "type": "external" } ], "gene_names_uniprotkb": "Adipoq; Acdc; Acrp30; Apm1", "gene_names_refseq": "30kDa; APN; Acdc; Acrp30; Adid; Adipoq; Ad; GBP28; adipo; apM1", "protein_names_uniprotkb": "Adiponectin; 30 kDa adipocyte complement-related protein; ACRP30; Adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ", "protein_names_refseq": "30 kDa adipocyte complement-related protein; adipocyte complement related protein; adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; adipocyte-specific protein AdipoQ; adiponectin d; adiponectin precursor", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); cardiomyopathy (Disease Ontology:DOID:0050700); peripheral artery disease (Disease Ontology:DOID:0050830); sleep apnea (Disease Ontology:DOID:0050847); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); polycystic ovary syndrome (Disease Ontology:DOID:11612); familial hyperlipidemia (Disease Ontology:DOID:1168); gestational diabetes (Disease Ontology:DOID:11714); Rett syndrome (Disease Ontology:DOID:1206); Graves' disease (Disease Ontology:DOID:12361); cardiovascular system disease (Disease Ontology:DOID:1287); dementia (Disease Ontology:DOID:1307); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); biliary atresia (Disease Ontology:DOID:13608); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); vascular disease (Disease Ontology:DOID:178); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); prostate adenocarcinoma (Disease Ontology:DOID:2526); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); coronary aneurysm (Disease Ontology:DOID:3362); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); amyloidosis (Disease Ontology:DOID:9120); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11450); (R-MMU-163680)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11162643;11382781;11479627;11479628;11912203;12840063;15734737;15760892;16621799;18787108;19592500;19855092;21750661;21769758;23209641;37507081;7592907;8631877;9512423", "class_list": "", "function": "Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 55, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q62400;Q6GTX4;Q9DC68", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005179 hormone activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0010875 positive regulation of cholesterol efflux;GO:0032869 cellular response to insulin stimulus;GO:0034612 response to tumor necrosis factor;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q60994-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100100001000.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ13-1", "uniprot_id": [ { "id": "COPRS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ13", "type": "external" } ], "mass": 18666.0, "length": 173, "protein_name": "Coordinator of PRMT5 and differentiation stimulator", "gene_name": "Coprs", "organism": "Mouse", "refseq_name": "coordinator of PRMT5 and differentiation stimulator isoform 1", "refseq_ac": [ { "id": "NP_079832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079832", "type": "external" } ], "gene_names_uniprotkb": "Coprs; Copr5", "gene_names_refseq": "1700029I03Rik; 2410022L05Rik; Copr5; Coprs", "protein_names_uniprotkb": "Coordinator of PRMT5 and differentiation stimulator; Cooperator of PRMT5", "protein_names_refseq": "cooperator of PRMT5; coordinator of PRMT5 and differentiation stimulator isoform 1; coordinator of PRMT5 and differentiation stimulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:66423); (R-MMU-3214858)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;22193545;28135057;30652083", "class_list": "", "function": "Data extend the role of COPR5 from an adaptor protein required for nuclear functions of PRMT5 to an essential coordinator of myogenic differentiation., [RefSeq, PubMed]; Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation., [UniProtKB, PubMed]; It shows that in mice, genetic inactivation of coprs (which is highly expressed in testis and encodes a histone-binding protein required for the targeting of Prmt5 activity) affects the maturation of spermatogonia to spermatids. Erratum:[FEBS Open Bio. 2019 Feb 28;9(3):558. doi: 10.1002/2211-5463.12607. PMID: 30868064] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0034709 methylosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007517 muscle organ development;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQ13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12787-1", "uniprot_id": [ { "id": "COX5A_MOUSE", "url": "https://www.uniprot.org/uniprot/P12787", "type": "external" } ], "mass": 16101.0, "length": 146, "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial", "gene_name": "Cox5a", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 5A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031773", "type": "external" } ], "gene_names_uniprotkb": "Cox5a", "gene_names_refseq": "CcOX; Cox5a", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va", "protein_names_refseq": "cytochrome c oxidase polypeptide Va; cytochrome c oxidase subunit 5A, mitochondrial precursor; cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase subunit Va", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); ciliopathy (Disease Ontology:DOID:0060340); mitochondrial complex IV deficiency nuclear type 20 (Disease Ontology:DOID:0070505); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (mmu:12858); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9837999); (R-MMU-9864848)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "11801660;16393994;22645316;23576753;2550898;25605945;26495903;26740625;34428180;34616041;36288343;38575788;39927985", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2W1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043209 myelin sheath;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P12787-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39061-3", "uniprot_id": [ { "id": "COIA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P39061", "type": "external" } ], "mass": 182172.0, "length": 1774, "protein_name": "Collagen alpha-1(XVIII) chain", "gene_name": "Col18a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XVIII) chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_001103461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103461", "type": "external" } ], "gene_names_uniprotkb": "Col18a1", "gene_names_refseq": "Col18a1", "protein_names_uniprotkb": "Collagen alpha-1(XVIII) chain", "protein_names_refseq": "alpha-1(XVIII) collagen; collagen alpha-1(XVIII) chain isoform 1 precursor; collagen alpha-1(XVIII) chain; endostatin; procollagen, type XVIII, alpha 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pigment dispersion syndrome (Disease Ontology:DOID:0060680); gastric ulcer (Disease Ontology:DOID:10808); dilated cardiomyopathy (Disease Ontology:DOID:12930); primary angle-closure glaucoma (Disease Ontology:DOID:1405); myopathy (Disease Ontology:DOID:423); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial myopathy (Disease Ontology:DOID:699); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:12822); (R-MMU-1442490); (R-MMU-1592389); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-216083); (R-MMU-8948216)", "pathway_count": 7, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10626789;10704302;10716919;10966814;11158588;11321448;12029087;19349973;25428506;30084848;31219806;34428180;35820727;38387749;7876242;8183893;8183894;8188673;8240330;8838808;9008168;9501087;9687493", "class_list": "glycogene", "function": "May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling., [UniProtKB, UniProtKB]; Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease., [RefSeq, PubMed]; Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (PubMed:9008168). Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2 (PubMed:12029087). Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:11158588). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q60672;Q61434;Q61437;Q62001;Q62002;Q6NZK9;Q6P1Y4;Q8CCZ8;Q9CRT2;Q9JK63", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0030198 extracellular matrix organization;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P39061-3", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84086-1", "uniprot_id": [ { "id": "CPLX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P84086", "type": "external" } ], "mass": 15394.0, "length": 134, "protein_name": "Complexin-2", "gene_name": "Cplx2", "organism": "Mouse", "refseq_name": "complexin-2", "refseq_ac": [ { "id": "NP_034076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034076", "type": "external" } ], "gene_names_uniprotkb": "Cplx2", "gene_names_refseq": "921-L; Cplx2; Gm34843", "protein_names_uniprotkb": "Complexin-2; 921-L; CPX II; Complexin II; Synaphin-1", "protein_names_refseq": "CPX II; complexin II; complexin-2; synaphin-1", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:12890)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11163241;12915444;15911881;16162394;16452087;20346398;23345244;32698012;38218537;7553862;7635198", "class_list": "", "function": "Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25., [RefSeq, PubMed]; Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic beta cell function., [RefSeq, PubMed]; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244). Also involved in mast cell exocytosis (PubMed:11163241). Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09056;Q13329;Q28184;Q32KK4;Q64386", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0000149 SNARE binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0050804 modulation of chemical synaptic transmission;GO:0031915 positive regulation of synaptic plasticity;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P84086-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPU9-1", "uniprot_id": [ { "id": "COPT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPU9", "type": "external" } ], "mass": 16069.0, "length": 143, "protein_name": "Protein SLC31A2", "gene_name": "Slc31a2", "organism": "Mouse", "refseq_name": "protein SLC31A2 isoform 2", "refseq_ac": [ { "id": "NP_001277447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277447", "type": "external" } ], "gene_names_uniprotkb": "Slc31a2", "gene_names_refseq": "CTR2; Slc31a2", "protein_names_uniprotkb": "Protein SLC31A2; CTR2; Copper transporter 2; Solute carrier family 31 member 2", "protein_names_refseq": "copper transporter 2; probable low affinity copper uptake protein 2; protein SLC31A2 isoform 2; protein SLC31A2; solute carrier family 31 (copper transporters), member 2", "tax_id": 10090, "disease": "Wilson disease (Disease Ontology:DOID:893)", "pathway": " (mmu:20530)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19144319;20930109;21183079;24167251;24522273;26342034;28507097;30779550;36232742", "class_list": "", "function": "Copper transporter 2 regulates the transport of cisplatin through control of the rate of macropinocytosis. Erratum:[Mol Pharmacol. 2011 May;79(5):894-8], [RefSeq, PubMed]; Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain., [RefSeq, PubMed]; Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Does not function as a copper(1+) importer in vivo (PubMed:24167251). However, in vitro functions as a low-affinity copper(1+) importer (By similarity). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (PubMed:24167251)., [UniProtKB, UniProtKB, PubMed]; Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2, [RefSeq, PubMed]; In mouse embryo fibroblasts, reduction of CTR1 expression renders cells resistant to cisplatin whereas reduction of CTR2 makes them hypersensitive both in vitro and in vivo., [RefSeq, PubMed]; The increase in granular staining and heparin content is compatible with an impact of Ctr2 on mast cell maturation and, in support of this, the absence of Ctr2 resulted in markedly increased mRNA expression, storage, and enzymatic activity of tryptase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006825 copper ion transport;GO:0015677 copper ion import;GO:1902311 regulation of copper ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CPU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60779-1", "uniprot_id": [ { "id": "DRC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60779", "type": "external" } ], "mass": 56264.0, "length": 478, "protein_name": "Dynein regulatory complex subunit 4", "gene_name": "Drc4; Gas8", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_061343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061343", "type": "external" } ], "gene_names_uniprotkb": "Drc4; Gas8; Gas11; Gas8", "gene_names_refseq": "Drc4; Gas11; Gas8", "protein_names_uniprotkb": "Dynein regulatory complex subunit 4; GAS-11; GAS-8; Growth arrest-specific protein 11; Growth arrest-specific protein 8", "protein_names_refseq": "GAS-11; GAS-8; beta growth arrest specific protein 11; dynein regulatory complex subunit 4 isoform 1; dynein regulatory complex subunit 4; growth arrest specific 11; growth arrest specific protein 11; growth arrest-specific protein 8", "tax_id": 10090, "disease": "primary ciliary dyskinesia 33 (Disease Ontology:DOID:0110619)", "pathway": " (mmu:104346); (R-MMU-5635838)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11751847;16643277;17366626;18396146;21659505;21750661;26387594;27472056;31961863;34428180", "class_list": "", "function": "A growth arrest specific gene regulated during male gametogensis, [RefSeq, PubMed]; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (PubMed:17366626, PubMed:21659505, PubMed:27472056). May play a role in the spermatozoa motility (PubMed:11751847)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Gas11, the mammalian trypanin/PF2 homologue, associates with microtubules in vitro and in vivo., [RefSeq, PubMed]; Here, we generate the first mouse with a Gas8 mutation and show that it causes severe Primary Ciliary Dyskinesia (PCD)phenotypes; however, there were no overt Hh pathway phenotypes. In addition, we identified two human patients with missense variants in Gas8 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L71", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0007420 brain development;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60779-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVH3-1", "uniprot_id": [ { "id": "FOXO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVH3", "type": "external" } ], "mass": 53649.0, "length": 505, "protein_name": "Forkhead box protein O4", "gene_name": "Foxo4", "organism": "Mouse", "refseq_name": "forkhead box protein O4", "refseq_ac": [ { "id": "NP_061259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061259", "type": "external" } ], "gene_names_uniprotkb": "Foxo4; Afx1; Afx; Fkhr3; Mllt7", "gene_names_refseq": "Afxh; Foxo4; Mllt7; afx", "protein_names_uniprotkb": "Forkhead box protein O4; Afxh; Fork head domain transcription factor AFX1", "protein_names_refseq": "fork head domain transcription factor AFX1; forkhead box protein O4; forkhead protein; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog", "tax_id": 10090, "disease": "gastric ulcer (Disease Ontology:DOID:10808); Parkinson's disease (Disease Ontology:DOID:14330); alcohol-induced mental disorder (Disease Ontology:DOID:251); paraplegia (Disease Ontology:DOID:607)", "pathway": " (mmu:54601); (R-MMU-198693); (R-MMU-5689880); (R-MMU-9614399); (R-MMU-9615017); (R-MMU-9617828)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10217147;11313479;11353388;11689711;11777915;11875118;12048180;16054032;21750661;22510882;22956541;29904119;34428180;37422776", "class_list": "", "function": "AFX (a Forkhead transcription factor = Foxo4) is expressed in the rodent ovary, [RefSeq, PubMed]; FoxO4 mediates macrophage M2 polarization by promoting LXA4R expression in an ovalbumin-induced allergic asthma model in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the regulation of GADD45 in response to oxidative stress and thereby contributes to G(2)-M checkpoint, [RefSeq, PubMed]; The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor., [RefSeq, PubMed]; Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (By similarity). Represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9WVH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AXV0-1", "uniprot_id": [ { "id": "FRS1L_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AXV0", "type": "external" } ], "mass": 32507.0, "length": 293, "protein_name": "DOMON domain-containing protein FRRS1L", "gene_name": "Frrs1l", "organism": "Mouse", "refseq_name": "DOMON domain-containing protein FRRS1L precursor", "refseq_ac": [ { "id": "NP_001136437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136437", "type": "external" } ], "gene_names_uniprotkb": "Frrs1l; 6430704M03Rik", "gene_names_refseq": "6430704M03Rik; Frrs1l", "protein_names_uniprotkb": "DOMON domain-containing protein FRRS1L; Ferric-chelate reductase 1-like protein", "protein_names_refseq": "DOMON domain-containing protein FRRS1L precursor; DOMON domain-containing protein FRRS1L; ferric-chelate reductase 1-like protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 37 (Disease Ontology:DOID:0080435)", "pathway": " (mmu:230235)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22632720;22645316;27236917;30692144;31604597;36330921", "class_list": "", "function": "Frrsl1 deletion results in an increased proportion of immature AMPA receptors, indicated by incomplete glycosylation of GLUA2 (also known as GRIA2) and GLUA4 (also known as GRIA4) AMPA receptor proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Important modulator of glutamate signaling pathway., [UniProtKB, UniProtKB]; Movement disorder caused by FRRS1L deficiency may be associated with morphological and functional disorders in Purkinje cells., [RefSeq, PubMed]; Our results provide mechanistic insight into the stepwise biogenesis of AMPA-receptors in native endoplasmic reticulum membranes and establish FRRS1l as a powerful regulator of synaptic signaling and plasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A3KMM1;Q8BYS5", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098794 postsynapse", "go_biological_process": "GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:1900449 regulation of glutamate receptor signaling pathway;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B1AXV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUY8-1", "uniprot_id": [ { "id": "GASP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUY8", "type": "external" } ], "mass": 92802.0, "length": 826, "protein_name": "G protein-coupled receptor-associated sorting protein 2", "gene_name": "Gprasp2", "organism": "Mouse", "refseq_name": "G-protein coupled receptor-associated sorting protein 2", "refseq_ac": [ { "id": "NP_001156487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156487", "type": "external" } ], "gene_names_uniprotkb": "Gprasp2", "gene_names_refseq": "5330440H13Rik; GASP-2; GASP2; Gprasp2; Prpl5", "protein_names_uniprotkb": "G protein-coupled receptor-associated sorting protein 2; GASP-2", "protein_names_refseq": "G-protein coupled receptor-associated sorting protein 2; prion protein ligand 5", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); X-linked deafness 7 (Disease Ontology:DOID:0111738); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:245607)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;25657005;28096187;32027737;34418635;34678516;38816497", "class_list": "", "function": "Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells., [RefSeq, PubMed]; GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation., [RefSeq, PubMed]; Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in regulation of a variety of G protein coupled receptors., [UniProtKB, UniProtKB]; Present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148X7", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BUY8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922K9-1", "uniprot_id": [ { "id": "FRK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922K9", "type": "external" } ], "mass": 58844.0, "length": 512, "protein_name": "Tyrosine-protein kinase FRK", "gene_name": "Frk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase FRK", "refseq_ac": [ { "id": "NP_001153016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153016", "type": "external" } ], "gene_names_uniprotkb": "Frk; Bsk; Iyk", "gene_names_refseq": "BSK/IYK; BSK; Frk; GTK; RAK", "protein_names_uniprotkb": "Tyrosine-protein kinase FRK; 2.7.10.2; BSK; Beta-cell Src-homology tyrosine kinase; FYN-related kinase; Intestine tyrosine kinase", "protein_names_refseq": "B-cell src-homology tyrosine kinase; beta-cell Src-homology tyrosine kinase; intestine tyrosine kinase; tyrosine-protein kinase FRK", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14302); (R-MMU-6798695); (R-MMU-8948751)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12077350;15186217;17416457;22872234;31219806;34428180;7733928;7835707", "class_list": "", "function": "Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity)., [UniProtKB]; These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61364;Q61745", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q922K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P91-1", "uniprot_id": [ { "id": "GPNMB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P91", "type": "external" } ], "mass": 63676.0, "length": 574, "protein_name": "Transmembrane glycoprotein NMB", "gene_name": "Gpnmb", "organism": "Mouse", "refseq_name": "transmembrane glycoprotein NMB precursor", "refseq_ac": [ { "id": "NP_444340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444340", "type": "external" } ], "gene_names_uniprotkb": "Gpnmb; Dchil; Hgfin; Nmb", "gene_names_refseq": "DC-HIL; Dchil; Gpnmb; ipd", "protein_names_uniprotkb": "Transmembrane glycoprotein NMB; DC-HIL; Dendritic cell-associated transmembrane protein; Osteoactivin", "protein_names_refseq": "dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; iris pigment dispersion; osteoactivin; transmembrane glycoprotein NMB precursor; transmembrane glycoprotein NMB", "tax_id": 10090, "disease": "pigment dispersion syndrome (Disease Ontology:DOID:0060680); primary localized cutaneous amyloidosis 3 (Disease Ontology:DOID:0080932); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:93695); (R-MMU-8857538)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11114299;12638126;17951401;19144319;21750661;25428506;25428507;27802388;30084848;30779550;34428180;35820727", "class_list": "glycogene", "function": "Could be a melanogenic enzyme., [UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 9, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 52, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3R9;Q8BVV9;Q8BXL4;Q9QXA0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0048018 receptor ligand activity;GO:0045545 syndecan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0031901 early endosome membrane;GO:0033162 melanosome membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0030335 positive regulation of cell migration;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99P91-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08842-1", "uniprot_id": [ { "id": "GFRA2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08842", "type": "external" } ], "mass": 51727.0, "length": 464, "protein_name": "GDNF family receptor alpha-2", "gene_name": "Gfra2", "organism": "Mouse", "refseq_name": "GDNF family receptor alpha-2 isoform 2", "refseq_ac": [ { "id": "NP_001289023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289023", "type": "external" } ], "gene_names_uniprotkb": "Gfra2; Gdnfrb; Trnr2", "gene_names_refseq": "Gfra2", "protein_names_uniprotkb": "GDNF family receptor alpha-2; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha-2; NRTNR-alpha; NTNR-alpha; Neurturin receptor alpha; TGF-beta-related neurotrophic factor receptor 2", "protein_names_refseq": "GDNF family receptor alpha-2 isoform 2; GDNF family receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR alpha 2; NRTNR-alpha; NTNR-alpha; TGF-beta-related neurotrophic factor receptor 2; neurturin receptor alpha", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (mmu:14586); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12829325;21750661;23872421;33300544;9182803;9875703", "class_list": "", "function": "Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3., [UniProtKB, PubMed]; Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed:9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:9182803). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (By similarity)., [UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUD8;Q920Y3;Q9Z2A2;Q9Z2A3", "ec_number_list": [], "go_molecular_function": "GO:1904399 heparan sulfate binding;GO:0016167 glial cell-derived neurotrophic factor receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0031953 negative regulation of protein autophosphorylation;GO:1904894 positive regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O08842-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35659-1", "uniprot_id": [ { "id": "GLP1R_MOUSE", "url": "https://www.uniprot.org/uniprot/O35659", "type": "external" } ], "mass": 53028.0, "length": 463, "protein_name": "Glucagon-like peptide 1 receptor", "gene_name": "Glp1r", "organism": "Mouse", "refseq_name": "glucagon-like peptide 1 receptor precursor", "refseq_ac": [ { "id": "NP_067307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067307", "type": "external" } ], "gene_names_uniprotkb": "Glp1r", "gene_names_refseq": "GLP-1R; GLP1Rc; Glp1r", "protein_names_uniprotkb": "Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R", "protein_names_refseq": "GLP-1 receptor; GLP-1-R; glucagon-like peptide 1 receptor precursor", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14652); (R-MMU-381676); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16946080;30084848;34428180;9568699", "class_list": "", "function": "G protein-coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:9568699). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (By similarity). Plays a role in regulating insulin secretion in response to GLP-1 (PubMed:9568699)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1JQR8", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038023 signaling receptor activity;GO:0004967 glucagon receptor activity;GO:0044508 glucagon-like peptide 1 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35659-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMF8-1", "uniprot_id": [ { "id": "GLDN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMF8", "type": "external" } ], "mass": 59137.0, "length": 549, "protein_name": "Gliomedin", "gene_name": "Gldn", "organism": "Mouse", "refseq_name": "gliomedin", "refseq_ac": [ { "id": "NP_796324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796324", "type": "external" } ], "gene_names_uniprotkb": "Gldn; Crgl2", "gene_names_refseq": "CRG-L2; Clom; Colm; Crgl2; Crlg2; Gldn", "protein_names_uniprotkb": "Gliomedin; CRG-L2; Cancer-related gene liver 2 protein", "protein_names_refseq": "cancer related gene - liver 2; cancer-related gene liver 2 protein; collomin; gliomedin; olfactomedin-related protein", "tax_id": 10090, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (mmu:235379)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12642876;16039564;17293346;20188654;23897819;24719088;26121352;32209430", "class_list": "", "function": "Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186)., [RefSeq, PubMed]; Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:20188654). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:20188654). Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088)., [UniProtKB, UniProtKB, PubMed, PubMed]; OLF domains from H. sapiens olfactomedin-1 and M. musculus gliomedin were biophysically, biochemically, and structurally characterized. Publication Status: Online-Only, [RefSeq, PubMed]; Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZC5", "ec_number_list": [], "go_molecular_function": "GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0007165 signal transduction;GO:0045162 clustering of voltage-gated sodium channels;GO:0032528 microvillus organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BMF8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31316-1", "uniprot_id": [ { "id": "GSX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P31316", "type": "external" } ], "mass": 32167.0, "length": 305, "protein_name": "GS homeobox 2", "gene_name": "Gsx2", "organism": "Mouse", "refseq_name": "GS homeobox 2", "refseq_ac": [ { "id": "NP_573555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573555", "type": "external" } ], "gene_names_uniprotkb": "Gsx2; Gsh-2; Gsh2", "gene_names_refseq": "Gsh-2; Gsh2; Gsx2", "protein_names_uniprotkb": "GS homeobox 2; Genetic-screened homeobox 2; Homeobox protein GSH-2", "protein_names_refseq": "GS homeobox 2; genetic-screened homeobox 2; genomic screened homeo box 2; homeobox protein GSH-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14843)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1683707;19709628;21750661;31219806;7619729", "class_list": "", "function": "Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:7619729). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (PubMed:19709628)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0021544 subpallium development;GO:0006351 DNA-templated transcription;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0002087 regulation of respiratory gaseous exchange by nervous system process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P31316-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43274-1", "uniprot_id": [ { "id": "H14_MOUSE", "url": "https://www.uniprot.org/uniprot/P43274", "type": "external" } ], "mass": 21977.0, "length": 219, "protein_name": "Histone H1.4", "gene_name": "H1-4", "organism": "Mouse", "refseq_name": "histone H1.4", "refseq_ac": [ { "id": "NP_056602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056602", "type": "external" } ], "gene_names_uniprotkb": "H1-4; H1f4; Hist1h1e", "gene_names_refseq": "H1 VAR.2; H1-4; H1.4; H1e; H1f4; H1s-4; H1var2; Hist1h1e", "protein_names_uniprotkb": "Histone H1.4; H1 VAR.2; H1e", "protein_names_refseq": "H1 histone family, member 4; histone 1, H1e; histone H1.4; histone H1e; histone cluster 1, H1e", "tax_id": 10090, "disease": "", "pathway": " (mmu:50709); (R-MMU-140342); (R-MMU-2559584)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "12808097;16377562;16452087;17242355;21183079;22645316;23806337;24463520;24788674;26495903;26740625;28011936;33300544;33725478;34428180;34887587;35820727;35984892;36288343;37453647;37507081;38098212;39627609;39927985;8190634;8416974;9655912", "class_list": "", "function": "Development of a mouse embryonic stem cell model for investigating the functions of the linker histone H1-4., [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:12808097, PubMed:16377562). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:12808097, PubMed:16377562). Ability to associate with nucleosomes and compact chromatin depends on linker DNA length and trajectory (By similarity). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (PubMed:12808097, PubMed:16377562)., [UniProtKB, UniProtKB, PubMed, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBH3", "ec_number_list": [], "go_molecular_function": "GO:0032564 dATP binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0016208 AMP binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P43274-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TI0-1", "uniprot_id": [ { "id": "ASTRB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TI0", "type": "external" } ], "mass": 85355.0, "length": 738, "protein_name": "Protein Aster-B", "gene_name": "Gramd1b", "organism": "Mouse", "refseq_name": "protein Aster-B isoform 1", "refseq_ac": [ { "id": "NP_766356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766356", "type": "external" } ], "gene_names_uniprotkb": "Gramd1b; Kiaa1201", "gene_names_refseq": "3222402H23; A930008A22Rik; Gramd1b; mKIAA1201", "protein_names_uniprotkb": "Protein Aster-B; GRAM domain-containing protein 1B", "protein_names_refseq": "GRAM domain-containing protein 1B; protein Aster-B isoform 1; protein Aster-B", "tax_id": 10090, "disease": "", "pathway": " (mmu:235283)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;30220461;32719109;32738348;34428180", "class_list": "", "function": "Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport., [RefSeq, PubMed]; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). Also mediates cholesterol transfer from lysosomes to endoplasmic reticulum through interaction with NPC1 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9768, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS56;Q8BZZ1;Q9CTQ2", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0001786 phosphatidylserine binding;GO:0070300 phosphatidic acid binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site;GO:0016020 membrane", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol;GO:0042632 cholesterol homeostasis;GO:0090120 lysosome to ER cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80TI0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWS5-1", "uniprot_id": [ { "id": "GRIN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWS5", "type": "external" } ], "mass": 80485.0, "length": 763, "protein_name": "G protein-regulated inducer of neurite outgrowth 3", "gene_name": "Gprin3", "organism": "Mouse", "refseq_name": "G protein-regulated inducer of neurite outgrowth 3", "refseq_ac": [ { "id": "NP_899006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899006", "type": "external" } ], "gene_names_uniprotkb": "Gprin3; Kiaa2027", "gene_names_refseq": "C030038J10Rik; C730021L23; Gprin3", "protein_names_uniprotkb": "G protein-regulated inducer of neurite outgrowth 3; GRIN3", "protein_names_refseq": "G protein-regulated inducer of neurite outgrowth 3; GRIN3", "tax_id": 10090, "disease": "", "pathway": " (mmu:243385)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15488195;17242355;21183079;29500670;31363062;34678516;40885482", "class_list": "", "function": "GRIN3 is involved in regulation of dopamine-dependent behaviors and is essential for activation of the dopamine receptors (DAR)-beta-arrestin signaling cascade., [RefSeq, PubMed]; May be involved in neurite outgrowth., [UniProtKB]; We identified GPRIN3 as a putative selective controller of D2R function in the striatum playing a critical role in striatal-associated behaviors and cellular functions, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z30", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:0098976 excitatory chemical synaptic transmission;GO:0007626 locomotory behavior;GO:0019228 neuronal action potential;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BWS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB00-1", "uniprot_id": [ { "id": "GON4L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB00", "type": "external" } ], "mass": 248742.0, "length": 2260, "protein_name": "GON-4-like protein", "gene_name": "Gon4l", "organism": "Mouse", "refseq_name": "GON-4-like protein isoform X2", "refseq_ac": [ { "id": "XP_036019278", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_036019278", "type": "external" } ], "gene_names_uniprotkb": "Gon4l; Gon4; Kiaa1606", "gene_names_refseq": "1500041I23Rik; 2610100B20Rik; 3632445O20Rik; 5430404N14Rik; AA387005; Gon4l", "protein_names_uniprotkb": "GON-4-like protein; GON-4 homolog", "protein_names_refseq": "GON-4-like protein isoform X2", "tax_id": 10090, "disease": "salivary gland cancer (Disease Ontology:DOID:8850)", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "20173027;20530203;21183079;21454521;21750661;25428506;30084848;30779550;34428180;34678516;35820727", "class_list": "", "function": "Acts as a key transcription regulator of histones (By similarity). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF. Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (By similarity). Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1 (PubMed:21454521). Required for B-cell lymphopoiesis (PubMed:20530203)., [UniProtKB, PubMed, UniProtKB, PubMed]; Acts as a key transcription regulator of histones. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF. Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription. Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1. Required for B-cell lymphopoiesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q5N3;Q80TB4;Q91YI9", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9DB00-1", "record_type": "protein", "filter_code": "0000000.1000110.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCM2-1", "uniprot_id": [ { "id": "GSTK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCM2", "type": "external" } ], "mass": 25704.0, "length": 226, "protein_name": "Glutathione S-transferase kappa 1", "gene_name": "Gstk1", "organism": "Mouse", "refseq_name": "glutathione S-transferase kappa 1", "refseq_ac": [ { "id": "NP_083831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083831", "type": "external" } ], "gene_names_uniprotkb": "Gstk1", "gene_names_refseq": "0610025I19Rik; DsbA-L; Gstk1", "protein_names_uniprotkb": "Glutathione S-transferase kappa 1; 2.5.1.18; GST 13-13; GST class-kappa; GSTK1-1; Glutathione S-transferase subunit 13; mGSTK1", "protein_names_refseq": "GST 13-13; GST class-kappa; GSTK1-1; glutathione S-transferase class kappa; glutathione S-transferase kappa 1; glutathione S-transferase subunit 13; mGSTK1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (mmu:76263); (R-MMU-156590); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "12720545;21750661;23576753;23806337;26740625;31599954;34428180;37226722;37379419;37453647;37507081;37597421", "class_list": "", "function": "DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity., [RefSeq, PubMed]; DsbA-L deletion attenuates LPS-induced acute kidney injury by modulating macrophage polarization., [RefSeq, PubMed]; DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy., [RefSeq, PubMed]; Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005737 cytoplasm", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0001889 liver development;GO:0030855 epithelial cell differentiation;GO:0010042 response to manganese ion;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DCM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43275-1", "uniprot_id": [ { "id": "H11_MOUSE", "url": "https://www.uniprot.org/uniprot/P43275", "type": "external" } ], "mass": 21785.0, "length": 213, "protein_name": "Histone H1.1", "gene_name": "H1-1", "organism": "Mouse", "refseq_name": "histone H1.1", "refseq_ac": [ { "id": "NP_085112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085112", "type": "external" } ], "gene_names_uniprotkb": "H1-1; H1a; H1f1; Hist1h1a", "gene_names_refseq": "H1-1; H1.1; H1a; H1f1; H1var3; Hist1h1a", "protein_names_uniprotkb": "Histone H1.1; H1 VAR.3; H1a; Histone H1a", "protein_names_refseq": "H1 VAR.3; H1 histone family, member 1; histone 1, H1a; histone H1.1; histone H1a; histone cluster 1, H1a", "tax_id": 10090, "disease": "", "pathway": " (mmu:80838); (R-MMU-140342); (R-MMU-2559584)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10666340;12408966;21183079;22645316;23806337;24463520;24788674;25428506;25605945;26495903;28011936;29187734;30084848;30779550;31219806;33725478;34428180;36288343;39927985;8190634;8639656;9655912", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SZ98", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0031982 vesicle;GO:0000791 euchromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006334 nucleosome assembly;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P43275-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97772-1", "uniprot_id": [ { "id": "GRM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97772", "type": "external" } ], "mass": 133212.0, "length": 1199, "protein_name": "Metabotropic glutamate receptor 1", "gene_name": "Grm1", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 1 isoform beta precursor", "refseq_ac": [ { "id": "NP_001107805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107805", "type": "external" } ], "gene_names_uniprotkb": "Grm1; Gprc1a; Mglur1", "gene_names_refseq": "4930455H15Rik; Gm10828; Gprc1a; Grm1; mGluR1; nmf373; rcw; wobl", "protein_names_uniprotkb": "Metabotropic glutamate receptor 1; mGluR1", "protein_names_refseq": "G protein-coupled receptor, family C, group 1, member A; metabotropic glutamate receptor 1 isoform beta precursor; metabotropic glutamate receptor 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 13 (Disease Ontology:DOID:0080062); spinocerebellar ataxia 44 (Disease Ontology:DOID:0080286); temporal lobe epilepsy (Disease Ontology:DOID:3328); uveal melanoma (Disease Ontology:DOID:6039); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:14816); (R-MMU-416476); (R-MMU-420499); (R-MMU-6794361)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10581402;16452087;17296554;21183079;24357660;26427409;27276689;28696429;31599954;33300544;33488348;37209824;37880287;40885482", "class_list": "", "function": "A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis., [RefSeq, PubMed]; Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed:26427409). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed:24357660, PubMed:27276689, PubMed:28696429)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXG4;Q9EPV6", "ec_number_list": [], "go_molecular_function": "GO:0001639 PLC activating G protein-coupled glutamate receptor activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0030331 nuclear estrogen receptor binding;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0019722 calcium-mediated signaling;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97772-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14DK4-1", "uniprot_id": [ { "id": "GPAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14DK4", "type": "external" } ], "mass": 89150.0, "length": 801, "protein_name": "Glycerol-3-phosphate acyltransferase 2, mitochondrial", "gene_name": "Gpat2", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate acyltransferase 2, mitochondrial", "refseq_ac": [ { "id": "NP_001074558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074558", "type": "external" } ], "gene_names_uniprotkb": "Gpat2", "gene_names_refseq": "A530057A03Rik; Gm116; Gpat2; xGPAT1", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 2, mitochondrial; 1-acylglycerol-3-phosphate O-acyltransferase GPAT2; 2.3.1.15; 2.3.1.51; GPAT-2; xGPAT1", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase GPAT2; GPAT-2; glycerol-3-phosphate acyltransferase 2, mitochondrial; glycerol-3-phosphate acyltransferase-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215456); (R-MMU-1483166); (R-MMU-75109)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17013544;17660561;17689486;21183079;22285183;22905194;23611983;25428506;26268560;28729426;30951587", "class_list": "", "function": "A novel murine glycerol-3-phosphate acyltransferase-like protein 1 (named xGPAT1) has been cloned., [RefSeq, PubMed]; Data suggest that Gpat2 is necessary for normal spermatogenesis; absence of Gpat2 up-regulates expression of apoptosis regulatory proteins, triggers apoptosis, and thereby decreases the number of dividing germ cells; Gpat2 knockdown (using RNA silencing) prevents germ cells from proceeding through pachytene stage. Publication Status: Online-Only, [RefSeq, PubMed]; GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in micedagger., [RefSeq, PubMed]; Thus, Gpat2 is expressed at a specific stage of spermatogenesis, consistent with piRNA synthesis and meiosis I prophase, [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]; Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids (PubMed:17013544, PubMed:17689486, PubMed:22905194). In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA) (PubMed:22905194). Prefers arachidonoyl-CoA as the acyl donor (PubMed:22905194). Required for primary processing step during piRNA biosynthesis (PubMed:23611983). Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity (PubMed:23611983)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AW16;Q0KK60;Q14CH8;Q6KAQ3;Q8BRZ9", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q14DK4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LP6-1", "uniprot_id": [ { "id": "GRPE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LP6", "type": "external" } ], "mass": 24307.0, "length": 217, "protein_name": "GrpE protein homolog 1, mitochondrial", "gene_name": "Grpel1", "organism": "Mouse", "refseq_name": "grpE protein homolog 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077798", "type": "external" } ], "gene_names_uniprotkb": "Grpel1", "gene_names_refseq": "Grpel1; mt-GrpE#1; mt-Grpel1", "protein_names_uniprotkb": "GrpE protein homolog 1, mitochondrial; Mt-GrpE#1", "protein_names_refseq": "grpE protein homolog 1, mitochondrial precursor; grpE protein homolog 1, mitochondrial", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:17713)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "23576753;23806337;24788674;28135057;28528544;31636012;36288343;37507081;37828378", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity)., [UniProtKB]; These data demonstrate that LIV-1-GRPEL1 axis dually regulates mitotic exit as well as apoptosis by interacting with PP2A B55alpha and AIF., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSZ3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006457 protein folding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99LP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WA9-1", "uniprot_id": [ { "id": "ABCG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WA9", "type": "external" } ], "mass": 72098.0, "length": 646, "protein_name": "ATP-binding cassette subfamily G member 4", "gene_name": "Abcg4", "organism": "Mouse", "refseq_name": "ATP-binding cassette subfamily G member 4", "refseq_ac": [ { "id": "NP_620405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620405", "type": "external" } ], "gene_names_uniprotkb": "Abcg4; White2", "gene_names_refseq": "6430517O04Rik; Abcg4", "protein_names_uniprotkb": "ATP-binding cassette subfamily G member 4; 7.6.2.-; ATP-binding cassette transporter White2", "protein_names_refseq": "ATP-binding cassette sub-family G member 4; ATP-binding cassette subfamily G member 4; ATP-binding cassette transporter White2; ATP-binding cassette, sub-family G (WHITE), member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:192663); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11856881;12137944;12183068;15210959;17916878;18039927;19633360;21750661;23584088;29042617;38668787", "class_list": "", "function": "ABCG1 and ABCG4 promote cholesterol efflux from cells to HDL, [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15210959, PubMed:17916878, PubMed:18039927). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (PubMed:29042617). Induces apoptosis in various cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Behavioral and Metabolic Effects of ABCG4 KO in the APP[swe,Ind] (J9) Mouse Model of Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; The loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior., [RefSeq, PubMed]; Transplantation of bone marrow deficient in ABCG4, a transporter of unknown function, into Ldlr(-/-) mice resulted in thrombocytosis, accelerated thrombosis and atherosclerosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4E1;Q8VBS9", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0010008 endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0010875 positive regulation of cholesterol efflux;GO:0055085 transmembrane transport;GO:0006355 regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91WA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WRF5-1", "uniprot_id": [ { "id": "A0A087WRF5_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WRF5", "type": "external" } ], "mass": 25788.0, "length": 222, "protein_name": "Predicted gene 28891; Predicted gene, 20792; Predicted gene, 20837; Predicted gene, 20838; Predicted gene, 21094; Predicted gene, 21256; Predicted gene, 21739; Predicted gene, 21861; Predicted gene, 57478", "gene_name": "Gm20792; Gm21739", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm20792; Gm21739; Gm20792; Gm20837; Gm20838; Gm21094; Gm21256; Gm21739; Gm21861; Gm28891; Gm57478", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 28891; Predicted gene, 20792; Predicted gene, 20837; Predicted gene, 20838; Predicted gene, 21094; Predicted gene, 21256; Predicted gene, 21739; Predicted gene, 21861; Predicted gene, 57478", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 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nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WRF5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QJK4-1", "uniprot_id": [ { "id": "F6QJK4_MOUSE", "url": "https://www.uniprot.org/uniprot/F6QJK4", "type": "external" } ], "mass": 17723.0, "length": 154, "protein_name": "RIKEN cDNA 4930444P10 gene", "gene_name": "4930444P10Rik", "organism": "Mouse", "refseq_name": "putative uncharacterized protein C8orf89 homolog", "refseq_ac": [ { "id": "NP_001230167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230167", "type": "external" } ], "gene_names_uniprotkb": "4930444P10Rik", "gene_names_refseq": "4930444P10Rik", "protein_names_uniprotkb": "RIKEN cDNA 4930444P10 gene", 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ribonuclease ZC3H12B", "refseq_ac": [ { "id": "NP_001030079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030079", "type": "external" } ], "gene_names_uniprotkb": "Zc3h12b", "gene_names_refseq": "A130028J20Rik; CXorf32; Gm373; Zc3h12b", "protein_names_uniprotkb": "Zinc finger CCCH-type containing 12B", "protein_names_refseq": "probable ribonuclease ZC3H12B", "tax_id": 10090, "disease": "", "pathway": " (mmu:547176)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18178554;21750661", "class_list": "", "function": "MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, 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"GO:0005634 nucleus;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3X9I7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PW05-1", "uniprot_id": [ { "id": "ZFP54_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PW05", "type": "external" } ], "mass": 68369.0, "length": 585, "protein_name": "Zinc finger protein 54", "gene_name": "Zfp54", "organism": "Mouse", "refseq_name": "zinc finger protein 54 isoform 1", "refseq_ac": [ { "id": "NP_035890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035890", "type": "external" } ], "gene_names_uniprotkb": "Zfp54", "gene_names_refseq": "2810034D10Rik; KRAB10; Zfp-54; Zfp54; Zfp76; mszf83", "protein_names_uniprotkb": "Zinc finger protein 54; KRAB10; Krueppel-associated box protein 10", "protein_names_refseq": "Krueppel-associated box protein 10; clone 18; zinc finger protein 54 isoform 1; zinc finger protein 76", "tax_id": 10090, "disease": "", "pathway": " (mmu:22712); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10384051;20624068;21750661;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PW05-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TRN9-1", "uniprot_id": [ { "id": "Q7TRN9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TRN9", "type": "external" } ], "mass": 35405.0, "length": 313, "protein_name": "Olfactory receptor family 56 subfamily A member 5", "gene_name": "Or56a5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or56a5; Olfr683", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor family 56 subfamily A member 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:259047); (R-MMU-381753)", 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], "mass": 43763.0, "length": 373, "protein_name": "Predicted gene, 21411", "gene_name": "Gm21411", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm21411", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 21411", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A571BDT7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHQ0-1", "uniprot_id": [ { "id": "FBX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHQ0", "type": "external" } ], "mass": 43777.0, "length": 385, "protein_name": "F-box only protein 4", "gene_name": "Fbxo4", "organism": "Mouse", "refseq_name": "F-box only protein 4", "refseq_ac": [ { "id": "NP_598860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598860", "type": "external" } ], "gene_names_uniprotkb": "Fbxo4; Fbx4", "gene_names_refseq": "1700096C12Rik; Fbx4; Fbxo4", "protein_names_uniprotkb": "F-box only protein 4", "protein_names_refseq": "F-box only protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:106052); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "17081987;18598945;19487455;19767775;21911473;22124152;24019069;25801820;29142209;29925002;34418053;37507081", "class_list": "", "function": "Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis, [RefSeq, PubMed]; Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 deregulation and nuclear accumulation, [RefSeq, PubMed]; Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase., [RefSeq, PubMed]; SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17081987, PubMed:18598945, PubMed:19767775, PubMed:29142209). Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation (PubMed:17081987, PubMed:18598945, PubMed:19767775). However, it does not act as a major regulator of CCND1 stability during the G1/S transition (PubMed:22124152). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; These findings suggest a role of Hsp20 in mediating adipocyte function by linking beta-adrenergic signaling to PPARgamma activity., [RefSeq, PubMed]; This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPM9;Q99JG8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0002183 cytoplasmic translational initiation;GO:0019725 cellular homeostasis;GO:1900181 negative regulation of protein localization to nucleus;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CHQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11688-1", "uniprot_id": [ { "id": "ITA5_MOUSE", "url": "https://www.uniprot.org/uniprot/P11688", "type": "external" } ], "mass": 115043.0, "length": 1053, "protein_name": "Integrin alpha-5", "gene_name": "Itga5", "organism": "Mouse", "refseq_name": "integrin alpha-5 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_034707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034707", "type": "external" } ], "gene_names_uniprotkb": "Itga5", "gene_names_refseq": "Cd49e; Fnra; Itga5; VLA5", "protein_names_uniprotkb": "Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5", "protein_names_refseq": "CD49 antigen-like family member E; fibronectin receptor alpha polypeptide; fibronectin receptor subunit alpha; integrin alpha-5 isoform 1 preproprotein; integrin alpha-5; integrin alpha-F", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:16402); (R-MMU-1566948); (R-MMU-1566977); (R-MMU-202733); (R-MMU-216083); (R-MMU-445144); (R-MMU-9634597); (R-MMU-9860927)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11121431;14535848;15229651;19349973;19656770;21750661;2523953;30899004;31219806;31599954;33300544;34428180;35820727;36812915;37828378;38796567;39441936;39627609;7508365", "class_list": "", "function": "Acute contact with profibrotic macrophages mechanically activates fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1., [RefSeq, PubMed]; IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin alpha5/FAK in diabetic kidney disease., [RefSeq, PubMed]; Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen (PubMed:36812915). It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "E9QN40", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding;GO:0005154 epidermal growth factor receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0007044 cell-substrate junction assembly;GO:0023035 CD40 signaling pathway;GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P11688-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WJ7-1", "uniprot_id": [ { "id": "LYRIC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WJ7", "type": "external" } ], "mass": 63846.0, "length": 579, "protein_name": "Protein LYRIC", "gene_name": "Mtdh", "organism": "Mouse", "refseq_name": "protein LYRIC isoform 3", "refseq_ac": [ { "id": "NP_080278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080278", "type": "external" } ], "gene_names_uniprotkb": "Mtdh; Lyric", "gene_names_refseq": "2610103J23Rik; 3D3/Lyric; 3D3; AEG-1; D8Bwg1112e; Lyric; Mtdh", "protein_names_uniprotkb": "Protein LYRIC; 3D3/LYRIC; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein", "protein_names_refseq": "lysine-rich CEACAM1 co-isolated protein; metastasis adhesion protein; protein LYRIC isoform 3; protein LYRIC", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:67154)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;14980505;15093543;16452087;17242355;18630941;21183079;21750661;23806337;26495903;30084848;34428180;34887587;35820727;37421418;37995969;38540798;38677511", "class_list": "", "function": "Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity)., [UniProtKB]; Expression patterns of AEG-1 in the normal brain., [RefSeq, PubMed]; Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Lyric is localized to the membrane of the endoplasmic reticulum, nuclear envelope, and the nucleolus., [RefSeq, PubMed]; Metadherin orchestrates PKA and PKM2 to activate beta-catenin signaling in podocytes during proteinuric chronic kidney disease., [RefSeq, PubMed]; Overexpression of metadherin is associated with metastatic breast cancer, [RefSeq, PubMed]; Spatial transcriptomics unravels palmitoylation and zonation-dependent gene regulation by AEG-1 in mouse liver., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RSG8;Q05CM0;Q3U9F8;Q3UAQ8;Q8BN67;Q8CBT9;Q8CDL0;Q8CGI7;Q9D052", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0051059 NF-kappaB binding;GO:0003725 double-stranded RNA binding;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q80WJ7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810M6-1", "uniprot_id": [ { "id": "LIAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810M6", "type": "external" } ], "mass": 25512.0, "length": 228, "protein_name": "Protein LIAT1", "gene_name": "Liat1", "organism": "Mouse", "refseq_name": "protein LIAT1", "refseq_ac": [ { "id": "NP_941039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941039", "type": "external" } ], "gene_names_uniprotkb": "Liat1", "gene_names_refseq": "1700016K19Rik; Liat1", "protein_names_uniprotkb": "Protein LIAT1; Ligand of ATE1 protein", "protein_names_refseq": "ligand of ATE1 protein; protein LIAT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74230)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25369936;33443146", "class_list": "", "function": "Liat1 interacts with Ate1 but does not appear to be its arginylation substrate. It has a higher affinity for the isoforms Ate1 1A7A and 1B7A. It stimulated N-terminal arginylation of a model substrate by Ate1. Sequelogs of other species are compared., [RefSeq, PubMed]; Participates in nucleolar liquid-liquid phase separation (LLPS) through its N-terminal intrinsically disordered region (IDR) (PubMed:33443146). May be involved in ATE1-mediated N-terminal arginylation (PubMed:25369936)., [UniProtKB, PubMed, PubMed]; The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016598 protein arginylation;GO:0140694 membraneless organelle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q810M6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWP4-1", "uniprot_id": [ { "id": "LY6K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWP4", "type": "external" } ], "mass": 17134.0, "length": 154, "protein_name": "Lymphocyte antigen 6K", "gene_name": "Ly6k", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6K precursor", "refseq_ac": [ { "id": "NP_083903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083903", "type": "external" } ], "gene_names_uniprotkb": "Ly6k", "gene_names_refseq": "2410015A16Rik; 3110035B01Rik; Ly6k; mLy-6K", "protein_names_uniprotkb": "Lymphocyte antigen 6K; Ly-6K", "protein_names_refseq": "ly-6K; lymphocyte antigen 6 complex, locus K; lymphocyte antigen 6K precursor; lymphocyte antigen 6K", "tax_id": 10090, "disease": "", "pathway": " (mmu:76486); (R-MMU-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18372042;18503752;20920470;24501175;27005865", "class_list": "", "function": "Expression profiling confirmed that mLy-6K is expressed by plasma cells but not B cells or tissues not containing plasma cells., [RefSeq, PubMed]; LY6K is a newly identified factor involved in sperm fertilizing ability Publication Status: Online-Only, [RefSeq, PubMed]; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (PubMed:24501175). May play a role in cell growth (By similarity)., [UniProtKB, PubMed, UniProtKB]; This information is essential for the molecular classification of Ly6k, and may help uncover the detailed physiological role of Ly6k in gametogenesis, or cancer biology., [RefSeq, PubMed]; This study confirmed the biological interaction between TEX101 and Ly6k., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MR8-1", "uniprot_id": [ { "id": "MCCA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MR8", "type": "external" } ], "mass": 79344.0, "length": 717, "protein_name": "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "gene_name": "Mccc1", "organism": "Mouse", "refseq_name": "methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "refseq_ac": [ { "id": "NP_076133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076133", "type": "external" } ], "gene_names_uniprotkb": "Mccc1; Mcca", "gene_names_refseq": "1810045E08Rik; 2310058B18Rik; MCCalpha; Mcca; Mccc1", "protein_names_uniprotkb": "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; 6.4.1.4; MCCase subunit alpha", "protein_names_refseq": "3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; MCCase subunit alpha; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "tax_id": 10090, "disease": "3-methylcrotonyl-CoA carboxylase 1 deficiency (Disease Ontology:DOID:0080579)", "pathway": " (mmu:72039); (R-MMU-196780); (R-MMU-70895)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11181649;21750661;23438705;23576753;23806337;25428506;30084848;31599954;34428180;35820727;36210013;36288343;37453647;37507081;39927985", "class_list": "", "function": "Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGU0;Q9D8R2", "ec_number_list": [ { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004485 methylcrotonoyl-CoA carboxylase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:1905202 methylcrotonoyl-CoA carboxylase complex", "go_biological_process": "GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99MR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D925-1", "uniprot_id": [ { "id": "LYZL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D925", "type": "external" } ], "mass": 16198.0, "length": 145, "protein_name": "Lysozyme-like protein 4", "gene_name": "Lyzl4", "organism": "Mouse", "refseq_name": "lysozyme-like protein 4 precursor", "refseq_ac": [ { "id": "NP_081191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081191", "type": "external" } ], "gene_names_uniprotkb": "Lyzl4; Lyc4", "gene_names_refseq": "1810009N24Rik; Lyc4; Lyza; Lyzl4", "protein_names_uniprotkb": "Lysozyme-like protein 4; Lysozyme-4", "protein_names_refseq": "lysozyme a; lysozyme-like protein 4 precursor; lysozyme-like protein 4", "tax_id": 10090, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:69032)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21444326;21750661;24013621", "class_list": "glycogene;glycosylhydrolase", "function": "Immuno-neutralization of Lyzl4 protein in spermatozoa with its specific antibody significantly decreased in vitro fertilization percentage in a dose-dependent manner, suggesting that Lyzl4 might be important for fertilization, [RefSeq, PubMed]; May be involved in fertilization (PubMed:21444326). Has no detectable bacteriolytic in vitro (PubMed:21444326). Has no lysozyme activity in vitro (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D925-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53349-1", "uniprot_id": [ { "id": "M3K1_MOUSE", "url": "https://www.uniprot.org/uniprot/P53349", "type": "external" } ], "mass": 161289.0, "length": 1493, "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "Map3k1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Map3k1; Mekk1; Mekk", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 1; 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "diffuse gastric cancer (Disease Ontology:DOID:0080763); 46,XY sex reversal 6 (Disease Ontology:DOID:0111769); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:26401); (R-MMU-166058); (R-MMU-2871796); (R-MMU-975138); (R-MMU-975871)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10523642;14500727;15262978;17761173;19144319;21183079;21750661;25605945;30084848;31219806;34428180;35820727;8385802;9078260", "class_list": "", "function": "Component of a protein kinase signal transduction cascade (PubMed:14500727). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:14500727). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:14500727)., [UniProtKB, PubMed, PubMed]; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q60831;Q9R0U3;Q9R256", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031941 filamentous actin;GO:0070160 tight junction", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53349-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JP0-1", "uniprot_id": [ { "id": "M4K3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JP0", "type": "external" } ], "mass": 101119.0, "length": 894, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 3", "gene_name": "Map4k3", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 3 isoform 1", "refseq_ac": [ { "id": "NP_001277274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277274", "type": "external" } ], "gene_names_uniprotkb": "Map4k3", "gene_names_refseq": "4833416M01Rik; 4833416M07Rik; 9530052P13Rik; Glk; MAPKKKK3; MEKKK 3; MEKKK3; Map4k3; RAB8IPL1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase 3; 2.7.11.1; GLK; Germinal center kinase-related protein kinase; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3", "protein_names_refseq": "MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; germinal center kinase-related protein kinase; mitogen-activated protein kinase kinase kinase kinase 3 isoform 1", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:225028)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16452087;21183079;21750661;30214937;34428180;35820727;35966593", "class_list": "", "function": "GLK induces IL-17A transcription by activating AhR and ROR-gammat.GLK controls IL-17A production and autoimmune responses through AhR. Publication Status: Online-Only, [RefSeq, PubMed]; MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation. Erratum:[Theranostics. 2026 Jan 30;16(8):4304-4305. doi: 10.7150/thno.125465. PMID: 41695492] Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PWI4;Q9CUS8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0017124 SH3 domain binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0034612 response to tumor necrosis factor;GO:0035556 intracellular signal transduction;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99JP0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXI5-1", "uniprot_id": [ { "id": "MANF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXI5", "type": "external" } ], "mass": 20388.0, "length": 179, "protein_name": "Mesencephalic astrocyte-derived neurotrophic factor", "gene_name": "Manf", "organism": "Mouse", "refseq_name": "mesencephalic astrocyte-derived neurotrophic factor precursor", "refseq_ac": [ { "id": "NP_083379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083379", "type": "external" } ], "gene_names_uniprotkb": "Manf; Armet", "gene_names_refseq": "3230402M22Rik; Armet; D18Mgi17; Manf", "protein_names_uniprotkb": "Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET", "protein_names_refseq": "arginine-rich protein; arginine-rich, mutated in early stage tumors; mesencephalic astrocyte-derived neurotrophic factor precursor", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); bacterial infectious disease (Disease Ontology:DOID:104); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:74840)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17507765;18034455;18718866;20214902;21750661;23956175;30543055;30710085;33939070;36739529;37118549;38159526;38759839;39289348", "class_list": "", "function": "ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum, [RefSeq, PubMed]; MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Mesencephalic Astrocyte-derived Neurotrophic Factor Supports Hepatitis B Virus-induced Immunotolerance., [RefSeq, PubMed]; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Stabilizes HSPA5/BiP in its substrate-bound ADP state, which facilitates HSPA5/BiP incorporation into chaperone-client complexes during endoplasmic reticulum stress, its interaction with HSPA5/BiP inhibits ATP binding to HSPA5/BiP and subsequent nucleotide exchange (PubMed:30710085). As a result acts as a repressor of the unfolded protein response (UPR) pathway (PubMed:30710085). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. Essential for embryonic lung development (PubMed:30543055). Required for the correct postnatal temporal and structural development of splenic white pulp (PubMed:38159526). Required for the repair-associated myeloid response in skeletal muscle, acts as a regulator of phenotypic transition towards prorepair macrophages in response to muscle injury and as a result limits excessive proinflammatory signaling (PubMed:37118549). Represses RELA expression and therefore NF-kB signaling in the myocardium, as a result limits macrophage infiltration of injured tissue and M1 macrophage differentiation in response to myocardial injury (PubMed:33939070). Required for endochondral ossification in long bones and the skull during postnatal development (PubMed:30543055)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The solution structure of ARMET, [RefSeq, PubMed]; The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMX5", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0120146 sulfatide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0048471 perinuclear region of cytoplasm;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure;GO:0036500 ATF6-mediated unfolded protein response;GO:1905897 regulation of response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CXI5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06801-1", "uniprot_id": [ { "id": "MAOX_MOUSE", "url": "https://www.uniprot.org/uniprot/P06801", "type": "external" } ], "mass": 63954.0, "length": 572, "protein_name": "NADP-dependent malic enzyme", "gene_name": "Me1", "organism": "Mouse", "refseq_name": "NADP-dependent malic enzyme isoform 2", "refseq_ac": [ { "id": "NP_001185862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185862", "type": "external" } ], "gene_names_uniprotkb": "Me1; Mod-1; Mod1", "gene_names_refseq": "D9Ertd267e; Mdh-1; Me1; Mod-1; Mod1", "protein_names_uniprotkb": "NADP-dependent malic enzyme; 1.1.1.40; Malic enzyme 1; NADP-ME", "protein_names_refseq": "NADP-ME; NADP-dependent malic enzyme isoform 2; NADP-dependent malic enzyme; malic enzyme, supernatant", "tax_id": 10090, "disease": "", "pathway": " (mmu:17436); (R-MMU-70268); (R-MMU-9861718)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21183079;30084848;31944402;34428180;3541755;37047583;37453647;37507081;3805042;38843233;39927985", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate., [UniProtKB, UniProtKB]; Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Malic enzyme 1 is important for uterine decidualization in response to progesterone/cAMP/PKA/HB-EGF pathway., [RefSeq, PubMed]; Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBF9", "ec_number_list": [ { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.7.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.5", "type": "external" }, { "id": "4.1.1.112", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112", "type": "external" }, { "id": "5.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" } ], "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0051289 protein homotetramerization;GO:0019674 NAD+ metabolic process;GO:0009725 response to hormone;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P06801-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20917-1", "uniprot_id": [ { "id": "MAG_MOUSE", "url": "https://www.uniprot.org/uniprot/P20917", "type": "external" } ], "mass": 69388.0, "length": 627, "protein_name": "Myelin-associated glycoprotein", "gene_name": "Mag", "organism": "Mouse", "refseq_name": "myelin-associated glycoprotein isoform 3 precursor", "refseq_ac": [ { "id": "NP_001333015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333015", "type": "external" } ], "gene_names_uniprotkb": "Mag", "gene_names_refseq": "Gma; Mag; siglec-4a", "protein_names_uniprotkb": "Myelin-associated glycoprotein; Siglec-4a", "protein_names_refseq": "myelin-associated glycoprotein isoform 3 precursor", "tax_id": 10090, "disease": "hereditary spastic paraplegia 75 (Disease Ontology:DOID:0110820); sciatic neuropathy (Disease Ontology:DOID:11446); multiple sclerosis (Disease Ontology:DOID:2377); middle cerebral artery infarction (Disease Ontology:DOID:3525); nerve compression syndrome (Disease Ontology:DOID:573)", "pathway": " (mmu:17136); (R-MMU-193634); (R-MMU-210991)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10625334;12089450;12558975;15953602;1712586;1716323;17640868;19158290;21183079;21750661;24191038;2474006;2482022;26335717;27922006;30899004;33300544;39327467;40885482;7516497;7533044;9262180;9469574;9482781;9482783", "class_list": "glycogene", "function": "Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:12089450, PubMed:27922006, PubMed:7533044). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination (PubMed:10625334, PubMed:7516497, PubMed:9262180, PubMed:9469574, PubMed:9482781, PubMed:9482783). Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2 (PubMed:26335717). Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (PubMed:15953602, PubMed:19158290). Negative regulator of neurite outgrowth that inhibits axon longitudinal growth (PubMed:12089450, PubMed:19158290, PubMed:27922006). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (By similarity). Inhibits axon outgrowth by binding to RTN4R (PubMed:12089450). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:27922006, PubMed:7533044). Binds ganglioside Gt1b (PubMed:27922006)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 1, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 1, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 1, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 2, "total_c_glycosites": 1, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 4, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 24, "disease_count": 5, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WPR1;P16880", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0035749 myelin sheath adaxonal region;GO:0043220 Schmidt-Lanterman incisure", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0007155 cell adhesion;GO:0022010 central nervous system myelination;GO:0045665 negative regulation of neuron differentiation;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 6.3, "record_id": "P20917-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1110000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5S006-1", "uniprot_id": [ { "id": "LRRK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5S006", "type": "external" } ], "mass": 284732.0, "length": 2527, "protein_name": "Leucine-rich repeat serine/threonine-protein kinase 2", "gene_name": "Lrrk2", "organism": "Mouse", "refseq_name": "leucine-rich repeat serine/threonine-protein kinase 2", "refseq_ac": [ { "id": "NP_080006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080006", "type": "external" } ], "gene_names_uniprotkb": "Lrrk2", "gene_names_refseq": "4921513O20Rik; 9330188B09Rik; D630001M17Rik; Gm927; Lrrk2; cI-46", "protein_names_uniprotkb": "Leucine-rich repeat serine/threonine-protein kinase 2; 2.7.11.1; 3.6.5.-", "protein_names_refseq": "leucine-rich repeat serine/threonine-protein kinase 2", "tax_id": 10090, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); Parkinson's disease 8 (Disease Ontology:DOID:0060371); Parkinsonism (Disease Ontology:DOID:0080855); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); rheumatoid arthritis (Disease Ontology:DOID:7148); Crohn's disease (Disease Ontology:DOID:8778); frontotemporal dementia (Disease Ontology:DOID:9255); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:66725); (R-MMU-8857538)", "pathway_count": 2, "publication_count": 49, "publication_id_list": "15541309;16487147;16504409;16532471;17120249;20642453;21183079;21390248;21806997;22335897;22723946;22736029;22863203;23066449;23190742;23318930;23395371;23526378;25107341;25201882;25939886;26005538;26824392;27474410;27658356;28103901;28292328;28720718;28821568;29125462;29212815;29707617;29855356;30194047;30209220;30398148;30949397;31149340;32434048;32643832;33105882;33135724;33298972;33367571;33459343;34428180;36210013;38227290;40885482", "class_list": "", "function": "Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815, PubMed:30398148). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815, PubMed:30398148). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29212815, PubMed:30398148). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (By similarity). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (By similarity). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (By similarity). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (By similarity). Phosphorylates PRDX3 (By similarity). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (By similarity). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (By similarity). In addition, has GTPase activity via its Roc domain which regulates LRKK2 kinase activity (By similarity). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QNJ2;Q8BWG7;Q8BZJ6;Q8CI84;Q8K062", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003779 actin binding;GO:0003924 GTPase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0031344 regulation of cell projection organization;GO:0051900 regulation of mitochondrial depolarization;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0060628 regulation of ER to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q5S006-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZQ8-1", "uniprot_id": [ { "id": "MARH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZQ8", "type": "external" } ], "mass": 32347.0, "length": 289, "protein_name": "E3 ubiquitin-protein ligase MARCHF1", "gene_name": "Marchf1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF1 isoform 1", "refseq_ac": [ { "id": "NP_001159844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159844", "type": "external" } ], "gene_names_uniprotkb": "Marchf1; March1", "gene_names_refseq": "2900024D24Rik; March1; Marchf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF1; 2.3.2.27; MARCH-I; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; RING-type E3 ubiquitin transferase MARCHF1", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH1; E3 ubiquitin-protein ligase MARCHF1 isoform 1; E3 ubiquitin-protein ligase MARCHF1; MARCH-I; RING-type E3 ubiquitin transferase MARCH1; RING-type E3 ubiquitin transferase MARCHF1; membrane-associated RING finger protein 1; membrane-associated RING-CH protein I; membrane-associated ring finger (C3HC4) 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72925)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "17051151;17255932;19880452;19917682;21059907;21220452;21750661;26495903;27577745;36100368;36451862;39115562", "class_list": "", "function": "E3 ubiquitin ligase MARCH1 reduces inflammation and pyroptosis in cerebral ischemia-reperfusion injury via PCSK9 downregulation., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:17051151, PubMed:17255932, PubMed:19880452). By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation (PubMed:27577745)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1, [RefSeq, PubMed]; MARCH-I may function as a housekeeper of conventional dendritic cell in the steady state., [RefSeq, PubMed]; MARCH1 Controls an Exhaustion-like Program of Effector CD4(+) T Cells Promoting Allergic Airway Inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; MARCH1 expression is regulated at a posttranscriptional level by trafficking within the endolysosomal pathway where MARCH1 is proteolyzed., [RefSeq, PubMed]; Selective ubiquitination of MHC-II in immature dendritic cells by the E3 ubiquitin ligase March-I results in the selective degradation of internalized pMHC-II., [RefSeq, PubMed]; Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Publication Status: Online-Only, [RefSeq, PubMed]; The function of MHC II in B cells is regulated through ubiquitination by MARCH-I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7M8;Q3UVF8;Q8C294;Q8CBA1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0042287 MHC protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0000209 protein polyubiquitination;GO:0002495 antigen processing and presentation of peptide antigen via MHC class II;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6NZQ8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGC4-1", "uniprot_id": [ { "id": "LS14B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGC4", "type": "external" } ], "mass": 42310.0, "length": 385, "protein_name": "Protein LSM14 homolog B", "gene_name": "Lsm14b", "organism": "Mouse", "refseq_name": "protein LSM14 homolog B isoform 2", "refseq_ac": [ { "id": "NP_808395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808395", "type": "external" } ], "gene_names_uniprotkb": "Lsm14b; Fam61b; Rap55b", "gene_names_refseq": "9430078B04; Lsm14b", "protein_names_uniprotkb": "Protein LSM14 homolog B; RNA-associated protein 55B; mRAP55B", "protein_names_refseq": "RNA-associated protein 55B; mRAP55B; protein LSM14 homolog B isoform 2; protein LSM14 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:241846)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18723115;24129315;28458300;36852467;37083226;37481122;37578641;37889087", "class_list": "", "function": "LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance., [RefSeq, PubMed]; mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes (PubMed:28458300, PubMed:37083226, PubMed:37481122, PubMed:37578641, PubMed:37889087). Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes (PubMed:37083226, PubMed:37481122, PubMed:37578641, PubMed:37889087). Promotes the translation of some oogenesis-related mRNAs (PubMed:37083226, PubMed:37578641). Regulates the expression and/or localization of some key P-body proteins in oocytes (PubMed:37481122). Essential for the assembly of the primordial follicle in the ovary (PubMed:37578641)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AC71", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036464 cytoplasmic ribonucleoprotein granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0001541 ovarian follicle development;GO:0048477 oogenesis;GO:0140694 membraneless organelle assembly;GO:1903537 meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CGC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIP4-1", "uniprot_id": [ { "id": "MARK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIP4", "type": "external" } ], "mass": 82644.0, "length": 752, "protein_name": "MAP/microtubule affinity-regulating kinase 4", "gene_name": "Mark4", "organism": "Mouse", "refseq_name": "MAP/microtubule affinity-regulating kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_758483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758483", "type": "external" } ], "gene_names_uniprotkb": "Mark4; Kiaa1860", "gene_names_refseq": "2410090P21Rik; Mark4; Markl1", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 4; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 4 isoform 1; MAP/microtubule affinity-regulating kinase 4L; MARK4 serine/threonine protein kinase", "tax_id": 10090, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:232944); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;15009667;16973293;21183079;21750661;22156016;22992738;24989893;28656979;30084848;31219806;32326642;33300544;34040253;34203471;34428180;35820727;36210013;38839927", "class_list": "", "function": "MARK4 aggravates cardiac dysfunction in mice with STZ-induced diabetic cardiomyopathy by regulating ACSL4-mediated myocardial lipid metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; MARK4 controls ischaemic heart failure through microtubule detyrosination., [RefSeq, PubMed]; MARK4 is a functional protein kinase which specifically phosphorylates a cognate peptide substrate for the AMP-kinase family. On overexpression in heterologous cells functional wild-type protein, but not its kinase-dead mutant, decreased cell viability, [RefSeq, PubMed]; Mark4 Inhibited the Browning of White Adipose Tissue by Promoting Adipocytes Autophagy in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (By similarity). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80T81", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008093 cytoskeletal anchor activity;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030425 dendrite;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8CIP4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YU6-1", "uniprot_id": [ { "id": "LZTS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YU6", "type": "external" } ], "mass": 72578.0, "length": 671, "protein_name": "Leucine zipper putative tumor suppressor 2", "gene_name": "Lzts2", "organism": "Mouse", "refseq_name": "leucine zipper putative tumor suppressor 2", "refseq_ac": [ { "id": "NP_001123997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123997", "type": "external" } ], "gene_names_uniprotkb": "Lzts2; Kiaa1813; Lapser1", "gene_names_refseq": "LAPSER1; Lzts2; mKIAA1813", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 2; Protein LAPSER1", "protein_names_refseq": "leucine zipper putative tumor suppressor 2; protein LAPSER1; putative tumor suppressor LAPSER1", "tax_id": 10090, "disease": "urinary system disease (Disease Ontology:DOID:18)", "pathway": " (mmu:226154)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18490357;21183079;21750661;21949185;23275340;28323888", "class_list": "", "function": "A critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin-mediated nephrogenesis., [RefSeq, PubMed]; Deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development., [RefSeq, PubMed]; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin., [UniProtKB, HAMAP]; The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt/beta-catenin signaling in prostate tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKK6;Q569X6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0051013 microtubule severing;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91YU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J21-1", "uniprot_id": [ { "id": "MCLN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J21", "type": "external" } ], "mass": 65506.0, "length": 580, "protein_name": "Mucolipin-1", "gene_name": "Mcoln1", "organism": "Mouse", "refseq_name": "mucolipin-1", "refseq_ac": [ { "id": "NP_444407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444407", "type": "external" } ], "gene_names_uniprotkb": "Mcoln1; Trpml1", "gene_names_refseq": "2210015I05Rik; Mcoln1; TRPML1; mucolipidin", "protein_names_uniprotkb": "Mucolipin-1; Mucolipidin; TRPML1; Transient receptor potential-mucolipin 1", "protein_names_refseq": "mucolipin-1; transient receptor potential-mucolipin 1", "tax_id": 10090, "disease": "Lisch epithelial corneal dystrophy (Disease Ontology:DOID:0060450); mucolipidosis type IV (Disease Ontology:DOID:0080490); glycoproteinosis (Disease Ontology:DOID:3343)", "pathway": " (mmu:94178); (R-MMU-3295583); (R-MMU-917977)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11897010;15345747;16606612;17050035;17208939;17989217;18794901;19144319;21183079;21750661;23993788;25428506;25733853;26495903;27623384;28936784;29019981;29187734;30084848;30899004;34428180;38924427;39080260", "class_list": "", "function": "HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway. Publication Status: Online-Only, [RefSeq, PubMed]; May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase., [UniProtKB, UniProtKB]; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:17989217, PubMed:18794901, PubMed:29019981). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:17989217). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (PubMed:23993788, PubMed:27623384). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (By similarity). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+), K(+) and Cs(+) (PubMed:17989217). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (By similarity). In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (PubMed:17050035)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer., [RefSeq, PubMed]; There is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0001891 phagocytic cup;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0090382 phagosome maturation;GO:0034755 iron ion transmembrane transport;GO:0051289 protein homotetramerization;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q99J21-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0L8-1", "uniprot_id": [ { "id": "MCES_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0L8", "type": "external" } ], "mass": 53291.0, "length": 465, "protein_name": "mRNA cap guanine-N(7) methyltransferase", "gene_name": "Rnmt", "organism": "Mouse", "refseq_name": "mRNA cap guanine-N(7) methyltransferase isoform 2", "refseq_ac": [ { "id": "NP_001164424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164424", "type": "external" } ], "gene_names_uniprotkb": "Rnmt; Kiaa0398", "gene_names_refseq": "2610002P10Rik; Rg7mt1; Rnmt; mKIAA0398", "protein_names_uniprotkb": "mRNA cap guanine-N(7) methyltransferase; 2.1.1.56; RG7MT1; mRNA (guanine-N(7))-methyltransferase; mRNA cap methyltransferase", "protein_names_refseq": "mRNA (guanine-N(7)-)-methyltransferase; mRNA cap guanine-N(7) methyltransferase isoform 2; mRNA cap guanine-N(7) methyltransferase; mRNA cap guanine-N7 methyltransferase; mRNA cap methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67897); (R-MMU-72086); (R-MMU-77075)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;19131326;19144319;21183079;21750661;28528544;29187734;34125914;34428180;37828378", "class_list": "", "function": "Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC., [UniProtKB, UniProtKB]; Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3U9;Q6ZQC6;Q9D5F1", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043235 receptor complex;GO:0001650 fibrillar center;GO:0031533 mRNA capping enzyme complex", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D0L8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7S0-1", "uniprot_id": [ { "id": "LYPD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7S0", "type": "external" } ], "mass": 27524.0, "length": 255, "protein_name": "Ly6/PLAUR domain-containing protein 8", "gene_name": "Lypd8", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 8 preproprotein", "refseq_ac": [ { "id": "NP_001077353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077353", "type": "external" } ], "gene_names_uniprotkb": "Lypd8", "gene_names_refseq": "2210415F13Rik; Lypd8", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 8", "protein_names_refseq": "ly6/PLAUR domain-containing protein 8 preproprotein; ly6/PLAUR domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:70163); (R-MMU-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "27027293;31659301;33822948", "class_list": "", "function": "Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease., [RefSeq, PubMed]; Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia., [RefSeq, PubMed]; Lypd8 prevents flagellated microbiota invading the colonic epithelia in mice; Lypd8 mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis, [RefSeq, PubMed]; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis., [UniProtKB, PubMed]; This gene encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. The encoded protein undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking the encoded protein are sensitive to chemically induced intestinal inflammation. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7S0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUC3-1", "uniprot_id": [ { "id": "LY6H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUC3", "type": "external" } ], "mass": 14669.0, "length": 139, "protein_name": "Lymphocyte antigen 6H", "gene_name": "Ly6h", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6H isoform b precursor", "refseq_ac": [ { "id": "NP_001129160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129160", "type": "external" } ], "gene_names_uniprotkb": "Ly6h", "gene_names_refseq": "Ly6h", "protein_names_uniprotkb": "Lymphocyte antigen 6H; Ly-6H", "protein_names_refseq": "ly-6H; lymphocyte antigen 6 complex, locus H; lymphocyte antigen 6H isoform b precursor; lymphocyte antigen 6H", "tax_id": 10090, "disease": "", "pathway": " (mmu:23934); (R-MMU-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10501842;25716842;26276394;32686737", "class_list": "", "function": "Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394). May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:25716842). Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Ly6h regulates alpha7 nAChRs cell-surface expression and nicotine-induced potentiation of glutamatergic mEPSC., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WD2-1", "uniprot_id": [ { "id": "TRPV6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WD2", "type": "external" } ], "mass": 87387.0, "length": 767, "protein_name": "Transient receptor potential cation channel subfamily V member 6", "gene_name": "Trpv6", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily V member 6", "refseq_ac": [ { "id": "NP_071858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071858", "type": "external" } ], "gene_names_uniprotkb": "Trpv6", "gene_names_refseq": "CAT; CaT1; Cac; Ecac2; Otrpc3; Trpv6", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 6; CaT1; Calcium transport protein 1; ECaC2; Epithelial calcium channel 2; TrpV6", "protein_names_refseq": "calcium transport protein 1; epithelial calcium channel 2; osmosensitive transient receptor potential channel 3; transient receptor potential cation channel subfamily V member 6", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); hyperparathyroidism (Disease Ontology:DOID:13543)", "pathway": " (mmu:64177); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11744752;12574114;12601087;12660155;12765696;14736889;15123711;16380433;17129178;18232717;20399919;21750661;22878123;23612980;36817471;37940780", "class_list": "", "function": "A non-AUG start codon is used in both human and mouse, extending the N-terminus of the protein by 40 amino acids. The increased translation of the smaller TRPV6 cDNA version may overestimate the in vivo situation where translation efficiency may represent an additional mechanism to tightly control the TRPV6-mediated Ca(2+) entry to prevent deleterious Ca(2+) overload., [RefSeq, PubMed]; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:12574114, PubMed:12601087, PubMed:12765696, PubMed:14736889, PubMed:15123711, PubMed:17129178). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (PubMed:17129178, PubMed:22878123). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation (PubMed:15123711). In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner (PubMed:12601087). Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; TRPV6 deficiency attenuates stress and corticosterone-mediated exacerbation of alcohol-induced gut barrier dysfunction and systemic inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; To characterize ECaC2 in more detail and to compare its properties with those of ECaC1 to obtain a better understanding of transcellular Ca2+ transport in epithelia., [RefSeq, PubMed]; Transient Receptor Potential Vanilloid 6 Modulates Aberrant Axonal Sprouting in a Mouse Model of Pilocarpine-Induced Epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion;GO:0006816 calcium ion transport;GO:0070588 calcium ion transmembrane transport;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q91WD2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q6P5-1", "uniprot_id": [ { "id": "TTC7B_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q6P5", "type": "external" } ], "mass": 94203.0, "length": 843, "protein_name": "Tetratricopeptide repeat protein 7B", "gene_name": "Ttc7b", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 7B isoform 1", "refseq_ac": [ { "id": "NP_001028385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028385", "type": "external" } ], "gene_names_uniprotkb": "Ttc7b", "gene_names_refseq": "Ttc7b; Ttc7l1", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 7B; TPR repeat protein 7B", "protein_names_refseq": "TPR repeat protein 7B; tetratricopeptide repeat protein 7B isoform 1; tetratricopeptide repeat protein 7B", "tax_id": 10090, "disease": "", "pathway": " (mmu:104718)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19144319;21183079;21750661;25428506", "class_list": "", "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9Q6P5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4Q9F0-1", "uniprot_id": [ { "id": "TTLL7_MOUSE", "url": "https://www.uniprot.org/uniprot/A4Q9F0", "type": "external" } ], "mass": 105501.0, "length": 912, "protein_name": "Tubulin polyglutamylase TTLL7", "gene_name": "Ttll7", "organism": "Mouse", "refseq_name": "tubulin polyglutamylase TTLL7 isoform Ttll7s", "refseq_ac": [ { "id": "NP_001289887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887", "type": "external" } ], "gene_names_uniprotkb": "Ttll7", "gene_names_refseq": "1110049N09Rik; 4921517B04Rik; C630030B20; Ttll7; mTTLL7", "protein_names_uniprotkb": "Tubulin polyglutamylase TTLL7; 6.3.2.-; Tubulin--tyrosine ligase-like protein 7; mTTLL7", "protein_names_refseq": "tubulin polyglutamylase TTLL7 isoform Ttll7s; tubulin polyglutamylase TTLL7; tubulin--tyrosine ligase-like protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:70892); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16901895;17499049;19152315;21750661;22872234;30779550;34428180;37238654", "class_list": "", "function": "Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:16901895, PubMed:17499049, PubMed:19152315). Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction (PubMed:16901895, PubMed:17499049, PubMed:19152315). Preferentially modifies the beta-tubulin tail over an alpha-tail (PubMed:16901895, PubMed:17499049, PubMed:19152315). Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (PubMed:16901895)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites, [RefSeq, PubMed]; TTLL7 performs both the initiation and elongation of polyglutamylation on beta-tubulin; the mechanism of binding of three substrates glutamate, ATP, and tubulin to the enzyme is a random sequential pathway., [RefSeq, PubMed]; Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4Q9E9;Q8C417;Q9D5V3", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0036064 ciliary basal body;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A4Q9F0-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIL5-1", "uniprot_id": [ { "id": "TULP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIL5", "type": "external" } ], "mass": 169638.0, "length": 1547, "protein_name": "Tubby-related protein 4", "gene_name": "Tulp4", "organism": "Mouse", "refseq_name": "tubby-related protein 4 isoform a", "refseq_ac": [ { "id": "NP_473381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473381", "type": "external" } ], "gene_names_uniprotkb": "Tulp4; Tusp", "gene_names_refseq": "1110057P05Rik; 2210038L17Rik; Tulp4; Tusp", "protein_names_uniprotkb": "Tubby-related protein 4; Tubby superfamily protein; Tubby-like protein 4", "protein_names_refseq": "tubby like protein 4; tubby super-family protein; tubby superfamily protein; tubby-related protein 4 isoform a; tubby-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:68842); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11595174;21750661;22645316;24129315;31219806;32782141;34678516;35820727;38115643;40021952;40885482", "class_list": "", "function": "Effects of Tulp4 deficiency on murine embryonic development and adult phenotype., [RefSeq, PubMed]; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RQP8;Q8CA75;Q922C2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JIL5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQI8-1", "uniprot_id": [ { "id": "TSYL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQI8", "type": "external" } ], "mass": 77671.0, "length": 677, "protein_name": "Testis-specific Y-encoded-like protein 2", "gene_name": "Tspyl2", "organism": "Mouse", "refseq_name": "testis-specific Y-encoded-like protein 2 isoform a", "refseq_ac": [ { "id": "NP_084112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084112", "type": "external" } ], "gene_names_uniprotkb": "Tspyl2; Cinap; DXBwg1396e; Dentt; Tspx", "gene_names_refseq": "CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E; E130307F10Rik; Tspyl2", "protein_names_uniprotkb": "Testis-specific Y-encoded-like protein 2; CASK-interacting nucleosome assembly protein; Differentially-expressed nucleolar TGF-beta1 target protein; TSPY-like protein 2", "protein_names_refseq": "CASK interacting nucleosome assembly protein; TSPY-like protein 2; cell division autoantigen 1 nucleolar protein; differentially expressed nucleolar TGF-beta1 target; nucleolar TGF-beta1 target protein; testis-specific Y-encoded-like protein 2 isoform a; testis-specific Y-encoded-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52808)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12112471;12619135;15066269;15241014;16374801;21183079;21750661;25428506;25605945;29311219;30051352;36640330", "class_list": "", "function": "DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT], [RefSeq, PubMed]; DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation., [RefSeq, PubMed]; HCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation., [RefSeq, PubMed]; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression., [UniProtKB, PubMed]; TSPYL2 is recruited to promoters of specific EZH2 target genes in neurons., [RefSeq, PubMed]; The identification that diabetes is associated with upregulation of vascular CDA1 and that CDA1 deletion in diabetic mice promotes aneurysm formation provides evidence that CDA1 plays a role in diabetes to reduce susceptibility to aneurysm formation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6WRI3;Q9CU22", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0006334 nucleosome assembly;GO:0008156 negative regulation of DNA replication;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TQI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46686-1", "uniprot_id": [ { "id": "TULP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P46686", "type": "external" } ], "mass": 62724.0, "length": 562, "protein_name": "Tubby-related protein 2", "gene_name": "Tulp2", "organism": "Mouse", "refseq_name": "tubby-related protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001039020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039020", "type": "external" } ], "gene_names_uniprotkb": "Tulp2; Pdet", "gene_names_refseq": "Pdet; Tulp2", "protein_names_uniprotkb": "Tubby-related protein 2; Protein P4-6; Tubby-like protein 2", "protein_names_refseq": "protein P4-6; testis specific phosphodiesterase; tubby-like protein 2; tubby-related protein 2 isoform 2; tubby-related protein 2", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56734)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19695251;21183079;21750661;7509194", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTV1;Q5FW93;Q8C5R7;Q8C5R9;Q9R1I8", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P46686-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW49-1", "uniprot_id": [ { "id": "TTC12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW49", "type": "external" } ], "mass": 78754.0, "length": 704, "protein_name": "Tetratricopeptide repeat protein 12", "gene_name": "Ttc12", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 12", "refseq_ac": [ { "id": "NP_766358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766358", "type": "external" } ], "gene_names_uniprotkb": "Ttc12", "gene_names_refseq": "E330017O07Rik; Ttc12", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 12; TPR repeat protein 12", "protein_names_refseq": "TPR repeat protein 12; tetratricopeptide repeat protein 12", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); primary ciliary dyskinesia 45 (Disease Ontology:DOID:0111857); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:235330)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;33300544", "class_list": "", "function": "Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007288 sperm axoneme assembly;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BW49-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHB8-1", "uniprot_id": [ { "id": "TTLL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHB8", "type": "external" } ], "mass": 147715.0, "length": 1328, "protein_name": "Tubulin polyglutamylase TTLL5", "gene_name": "Ttll5", "organism": "Mouse", "refseq_name": "tubulin polyglutamylase TTLL5 isoform 1", "refseq_ac": [ { "id": "NP_001074892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074892", "type": "external" } ], "gene_names_uniprotkb": "Ttll5; Kiaa0998", "gene_names_refseq": "1700048H13Rik; 2310009M18Rik; 4930556H18Rik; D630041K24Rik; Stamp; Ttll5; mKIAA0998", "protein_names_uniprotkb": "Tubulin polyglutamylase TTLL5; 6.3.2.-; Tubulin--tyrosine ligase-like protein 5", "protein_names_refseq": "polyglutamylase; tubulin polyglutamylase TTLL5 isoform 1; tubulin tyrosine ligase like family 5; tubulin--tyrosine ligase-like protein 5", "tax_id": 10090, "disease": "cone-rod dystrophy 19 (Disease Ontology:DOID:0111025)", "pathway": " (mmu:320244); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17499049;21750661;23558686;27162334;28173158;31219806;34428180", "class_list": "", "function": "Mouse models carrying truncating mutations in TTLL5 gene display reduced fertility in male animals., [RefSeq, PubMed]; Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049). Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step (PubMed:17499049). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (By similarity). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity)., [UniProtKB, PubMed, UniProtKB]; STAMP appears to participate in a unique, tissue-selective TTLL-mediated pathway for alpha-tubulin polyglutamylation that is required for sperm maturation and motility and may be relevant for male fertility., [RefSeq, PubMed]; Study uncovers the pathogenic mechanism whereby absence of RPGR(ORF15) glutamylation leads to retinal pathology in patients with TTLL5 gene mutations and connects these two genes into a common disease pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4Q9E7;Q3V468;Q8C1F0;Q8CFV5;Q9CVS6", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106437 protein-glutamic acid ligase activity, initiating", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0030317 flagellated sperm motility;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CHB8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925H1-1", "uniprot_id": [ { "id": "TRPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925H1", "type": "external" } ], "mass": 141035.0, "length": 1281, "protein_name": "Zinc finger transcription factor Trps1", "gene_name": "Trps1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trps1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger transcription factor Trps1", "protein_names_refseq": "", "tax_id": 10090, "disease": "trichorhinophalangeal syndrome type III (Disease Ontology:DOID:0080376); trichorhinophalangeal syndrome type I (Disease Ontology:DOID:14743); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:83925)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11285235;12885770;19389374;21183079;21750661;36852467", "class_list": "", "function": "Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q925H1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LG4-1", "uniprot_id": [ { "id": "TTC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LG4", "type": "external" } ], "mass": 48795.0, "length": 440, "protein_name": "Tetratricopeptide repeat protein 5", "gene_name": "Ttc5", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 5 isoform a", "refseq_ac": [ { "id": "NP_001074418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074418", "type": "external" } ], "gene_names_uniprotkb": "Ttc5; Strap", "gene_names_refseq": "Ttc5", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 5; Protein Strap; Stress-responsive activator of p300; TPR repeat protein 5", "protein_names_refseq": "TPR repeat protein 5; protein Strap; stress-responsive activator of p300; tetratricopeptide repeat protein 5 isoform a; tetratricopeptide repeat protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:219022); (R-MMU-6804760)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11511361;15448695;18451878;18833288;19011621;21750661;22362889;25168243;30084848;30420355;31599954", "class_list": "", "function": "Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair (PubMed:11511361, PubMed:15448695, PubMed:18451878, PubMed:30420355). In physiological conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex (PubMed:30420355). Acts as a negative regulator of nutrient stress-induced autophagy by inhibiting JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (PubMed:30420355). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin (By similarity). To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (By similarity). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability (PubMed:15448695, PubMed:18833288). Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361). Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53 (PubMed:19011621). In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2 (PubMed:11511361). Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival (PubMed:18451878). Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis (PubMed:25168243). Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (PubMed:25168243)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTN5;Q3TZL6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0009267 cellular response to starvation;GO:0061014 positive regulation of mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99LG4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6E4-1", "uniprot_id": [ { "id": "TTC9B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6E4", "type": "external" } ], "mass": 25909.0, "length": 239, "protein_name": "Tetratricopeptide repeat protein 9B", "gene_name": "Ttc9b", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 9B", "refseq_ac": [ { "id": "NP_082693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082693", "type": "external" } ], "gene_names_uniprotkb": "Ttc9b", "gene_names_refseq": "2900074C18Rik; Ttc9b", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 9B; TPR repeat protein 9B", "protein_names_refseq": "TPR repeat protein 9B; tetratricopeptide repeat protein 9B", "tax_id": 10090, "disease": "", "pathway": " (mmu:73032)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYN8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D6E4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTR1-1", "uniprot_id": [ { "id": "TRPV2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTR1", "type": "external" } ], "mass": 85965.0, "length": 756, "protein_name": "Transient receptor potential cation channel subfamily V member 2", "gene_name": "Trpv2", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily V member 2 isoform 1", "refseq_ac": [ { "id": "NP_035836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035836", "type": "external" } ], "gene_names_uniprotkb": "Trpv2; Grc", "gene_names_refseq": "GRC; OTRPC2; Trpv2; VRL-1; Vrl1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 2; GRC; Growth factor-regulated calcium channel; OTRPC2; Osm-9-like TRP channel 2; TrpV2", "protein_names_refseq": "growth factor regulated channel; growth factor-regulated calcium channel; osm-9-like TRP channel 2; transient receptor potential cation channel subfamily V member 2 isoform 1; vanilloid receptor-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22368); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10559903;11707512;14622291;19144319;21183079;29187734;38007144;38353705;38613787;39227967", "class_list": "", "function": "Analysis of glycosylation and localization in comparison to the endogenously expressed protein in F-11 cells, [RefSeq, PubMed]; Calcium-permeable, non-selective cation channel (PubMed:10559903). Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator (PubMed:10559903, PubMed:11707512). May transduce physical stimuli in mast cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta., [RefSeq, PubMed]; Ion channel TRPV2 is critical in enhancing B cell activation and function., [RefSeq, PubMed]; Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99K71", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0009266 response to temperature stimulus;GO:0045773 positive regulation of axon extension;GO:0090280 positive regulation of calcium ion import;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WTR1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04426-1", "uniprot_id": [ { "id": "WNT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P04426", "type": "external" } ], "mass": 41086.0, "length": 370, "protein_name": "Proto-oncogene Wnt-1", "gene_name": "Wnt1", "organism": "Mouse", "refseq_name": "proto-oncogene Wnt-1 precursor", "refseq_ac": [ { "id": "NP_067254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067254", "type": "external" } ], "gene_names_uniprotkb": "Wnt1; Int-1; Wnt-1", "gene_names_refseq": "Int-1; Wnt-1; Wnt1; swaying; sw", "protein_names_uniprotkb": "Proto-oncogene Wnt-1; Proto-oncogene Int-1", "protein_names_refseq": "proto-oncogene Int-1; proto-oncogene Wnt-1 precursor; proto-oncogene Wnt-1; proto-oncogene protein Wnt-1; wingless-related MMTV integration site 1", "tax_id": 10090, "disease": "osteogenesis imperfecta type 15 (Disease Ontology:DOID:0110347); breast cancer (Disease Ontology:DOID:1612); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22408); (R-MMU-201681); (R-MMU-3238698); (R-MMU-4086400); (R-MMU-4641262)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10866835;15454084;16116452;16543246;19841259;2202907;2279700;23499309;23656646;3018519;3594565;3594566;6091914", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (PubMed:15454084, PubMed:16116452). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (PubMed:16116452, PubMed:2202907). Has a role in osteoblast function, bone development and bone homeostasis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019904 protein domain specific binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0021551 central nervous system morphogenesis;GO:0022037 metencephalon development;GO:0021536 diencephalon development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P04426-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MN9-1", "uniprot_id": [ { "id": "PCCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MN9", "type": "external" } ], "mass": 58409.0, "length": 541, "protein_name": "Propionyl-CoA carboxylase beta chain, mitochondrial", "gene_name": "Pccb", "organism": "Mouse", "refseq_name": "propionyl-CoA carboxylase beta chain, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_001298078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298078", "type": "external" } ], "gene_names_uniprotkb": "Pccb", "gene_names_refseq": "1300012P06Rik; Pccb", "protein_names_uniprotkb": "Propionyl-CoA carboxylase beta chain, mitochondrial; 6.4.1.3; PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta", "protein_names_refseq": "PCCase subunit beta; propanoyl-CoA:carbon dioxide ligase subunit beta; propionyl-CoA carboxylase beta chain, mitochondrial isoform 2 precursor; propionyl-CoA carboxylase beta chain, mitochondrial", "tax_id": 10090, "disease": "propionic acidemia (Disease Ontology:DOID:14701); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:66904); (R-MMU-196780); (R-MMU-71032); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11245989;21750661;23576753;23806337;26740625;36288343;37453647;37507081", "class_list": "", "function": "This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBG2", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004658 propionyl-CoA carboxylase activity;GO:0003989 acetyl-CoA carboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1902494 catalytic complex;GO:0009317 acetyl-CoA carboxylase complex", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99MN9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FE9-1", "uniprot_id": [ { "id": "TSH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FE9", "type": "external" } ], "mass": 114223.0, "length": 1030, "protein_name": "Teashirt homolog 2", "gene_name": "Tshz2", "organism": "Mouse", "refseq_name": "teashirt homolog 2 isoform a", "refseq_ac": [ { "id": "NP_536703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536703", "type": "external" } ], "gene_names_uniprotkb": "Tshz2; Kiaa4248; Sdccag33l; Tsh2; Zfp218; Znf218", "gene_names_refseq": "2900073F20Rik; B830045G17; Mtsh2; Sdccag33l; Tsh2; Tshz2; Zfp218; mKIAA4248; teashirt2", "protein_names_uniprotkb": "Teashirt homolog 2; SDCCAG33-like protein; Zinc finger protein 218", "protein_names_refseq": "SDCCAG33-like protein; serologically defined colon cancer antigen 33 like; teashirt 2; teashirt homolog 2 isoform a; teashirt homolog 2; zinc finger protein 218", "tax_id": 10090, "disease": "", "pathway": " (mmu:228911)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10704881;14973285;19343227;19745106;21183079;21750661;32782141", "class_list": "", "function": "Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTF1;Q6AXH5;Q9JL71", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q68FE9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54887-1", "uniprot_id": [ { "id": "TSKS_MOUSE", "url": "https://www.uniprot.org/uniprot/O54887", "type": "external" } ], "mass": 63505.0, "length": 585, "protein_name": "Testis-specific serine kinase substrate", "gene_name": "Tsks", "organism": "Mouse", "refseq_name": "testis-specific serine kinase substrate isoform 1", "refseq_ac": [ { "id": "NP_035781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035781", "type": "external" } ], "gene_names_uniprotkb": "Tsks; Stk22s1", "gene_names_refseq": "Stk22s1; Tsks; Tssks1", "protein_names_uniprotkb": "Testis-specific serine kinase substrate; STK22 substrate 1; Testis-specific kinase substrate", "protein_names_refseq": "STK22 substrate 1; clone 4; serine/threonine kinase 22 substrate 1; testis-specific kinase substrate; testis-specific serine kinase substrate isoform 1; testis-specific serine/threonine kinase substrate 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22116)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18495105;18533145;20053632;21750661;24088291;34428180;36881620;9412477", "class_list": "", "function": "In elongating spermatids, data detected accumulation of the testis-specific TSSK1 and TSSK2, and the substrate TSKS, in a ring-shaped structure around the base of the flagellum and in a cytoplasmic satellite., [RefSeq, PubMed]; In mouse testis, PPP1CC2 can form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS. Interaction between PPP1CC2 and TSKS is mediated through an RVxF docking motif on the TSKS surface. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development., [UniProtKB]; TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation., [RefSeq, PubMed]; This gene is a member of a small family of testis-specific serine/threonine kinases. This gene may play a role in testicular physiology or spermiogenesis. Its expression is restricted to the testis during the last stages of spermatid maturation. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJS9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54887-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBN4-1", "uniprot_id": [ { "id": "P33MX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBN4", "type": "external" } ], "mass": 32715.0, "length": 303, "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "4833439L19Rik; P33monox", "organism": "Mouse", "refseq_name": "putative monooxygenase p33MONOX isoform 2", "refseq_ac": [ { "id": "NP_001239574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239574", "type": "external" } ], "gene_names_uniprotkb": "4833439L19Rik; P33monox; Kiaa1191", "gene_names_refseq": "4833439L19Rik; 4930558H15Rik; Kiaa1191; P33monox", "protein_names_uniprotkb": "Putative monooxygenase p33MONOX; 1.-.-.-", "protein_names_refseq": "putative monooxygenase p33MONOX isoform 2; putative monooxygenase p33MONOX", "tax_id": 10090, "disease": "", "pathway": " (mmu:97820)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;19144319;21153684;21183079;21750661;31219806;34428180", "class_list": "", "function": "Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ26;Q3UMA7;Q69ZP2;Q8C1J8;Q9D4T9", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66JY6-1", "uniprot_id": [ { "id": "ARG39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66JY6", "type": "external" } ], "mass": 39106.0, "length": 344, "protein_name": "Rho guanine nucleotide exchange factor 39", "gene_name": "Arhgef39", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 39", "refseq_ac": [ { "id": "NP_001013395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013395", "type": "external" } ], "gene_names_uniprotkb": "Arhgef39; E130306D19Rik", "gene_names_refseq": "Arhgef39; E130306D19Rik", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 39", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 39; rho guanine nucleotide exchange factor 39; vav-like protein C9orf100 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:230098); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;29187734", "class_list": "", "function": "Promotes cell proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIN0;Q3TQV6", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66JY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M51-1", "uniprot_id": [ { "id": "NCK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M51", "type": "external" } ], "mass": 42891.0, "length": 377, "protein_name": "SH2/SH3 adapter protein Nck1", "gene_name": "Nck1", "organism": "Mouse", "refseq_name": "SH2/SH3 adapter protein Nck1 isoform 1", "refseq_ac": [ { "id": "NP_035008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035008", "type": "external" } ], "gene_names_uniprotkb": "Nck1", "gene_names_refseq": "6330586M15Rik; D230010O13Rik; Nck-1; Nck1; Nck", "protein_names_uniprotkb": "SH2/SH3 adapter protein Nck1; Cytoplasmic protein Nck1; NCK adapter protein 1; Nck-1", "protein_names_refseq": "NCK adapter protein 1; NCK adaptor protein 1; SH2/SH3 adapter protein Nck1 isoform 1; SH2/SH3 adapter protein Nck1; cytoplasmic protein NCK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17973); (R-MMU-186763); (R-MMU-202433); (R-MMU-2029482); (R-MMU-373753); (R-MMU-418885); (R-MMU-4420097); (R-MMU-5663213); (R-MMU-9013420); (R-MMU-9013424); (R-MMU-9833482); (R-MMU-983695)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "18034455;21183079;21750661;36535770;37479911;9722576", "class_list": "", "function": "Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. Also acts as an adpater protein for the T cell receptor complex (TCR-CD3E). Upon ligand engagement, is recruited by CD3E and promotes maturation of the immune synapse and T cell activation., [UniProtKB, UniProtKB]; Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development. Publication Status: Online-Only, [RefSeq, PubMed]; NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55032;Q9Z279", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0051707 response to other organism;GO:1903679 positive regulation of cap-independent translational initiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99M51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97820-1", "uniprot_id": [ { "id": "M4K4_MOUSE", "url": "https://www.uniprot.org/uniprot/P97820", "type": "external" } ], "mass": 140602.0, "length": 1233, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 4", "gene_name": "Map4k4", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_001239129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239129", "type": "external" } ], "gene_names_uniprotkb": "Map4k4; Nik", "gene_names_refseq": "9430080K19Rik; HGK; Map4k4; Nik", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase 4; 2.7.11.1; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase", "protein_names_refseq": "HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; NCK interacting kinase; mitogen-activated protein kinase kinase kinase kinase 4 isoform 1; nck-interacting kinase", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); epilepsy (Disease Ontology:DOID:1826); hepatitis B (Disease Ontology:DOID:2043); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:26921); (R-MMU-2559580)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10669731;15345747;21183079;21750661;28528544;30699345;31219806;33300544;36207400;37290629;38229581;9135144", "class_list": "", "function": "Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways., [RefSeq, PubMed]; MAP4K4 is involved in the neuronal development of retinal photoreceptors., [RefSeq, PubMed]; Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. Appears to act upstream of the JUN N-terminal pathway (PubMed:10669731, PubMed:9135144). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr-322 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; These studies highlight a MAP4K4-initiated signaling cascade that induces motor neuron degeneration., [RefSeq, PubMed]; Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008349 MAP kinase kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P97820-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97433-1", "uniprot_id": [ { "id": "ARG28_MOUSE", "url": "https://www.uniprot.org/uniprot/P97433", "type": "external" } ], "mass": 190489.0, "length": 1700, "protein_name": "Rho guanine nucleotide exchange factor 28", "gene_name": "Arhgef28", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 28 isoform 1", "refseq_ac": [ { "id": "NP_036156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036156", "type": "external" } ], "gene_names_uniprotkb": "Arhgef28; Kiaa1998; Rgnef; Rhoip2; Rip2", "gene_names_refseq": "9230110L08Rik; Arhgef28; D13Bwg1089e; RIP2; Rgnef; RhoGEF; Rhoip2; p190RhoGEF", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 28; 190 kDa guanine nucleotide exchange factor; Rho guanine nucleotide exchange factor; Rho-interacting protein 2; p190-RhoGEF; p190RhoGEF", "protein_names_refseq": "190 kDa guanine nucleotide exchange factor; Rho guanine nucleotide exchange factor (GEF) 28; Rho interacting protein 2; Rho specific exchange factor; Rho-guanine nucleotide exchange factor; p190-RhoGEF; rho guanine nucleotide exchange factor 28 isoform 1; rho-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:110596); (R-MMU-3928662); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10574993;11058585;11435431;11533041;12496377;12702722;14499478;15378065;16236762;17993462;18195107;21183079;21750661;28495450;31308489;37628966;40885482;9199174", "class_list": "", "function": "A new role for Rgnef in ovarian cancer to facilitate NF-kappaB-mediated gene expression protecting cells from oxidative stress., [RefSeq, PubMed]; Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Observed that the expression of RGNEF is upregulated in murine spinal motor neurons following distal sciatic nerve injury, [RefSeq, PubMed]; Over-Expression of p190RhoGEF Regulates the Formation of Atherosclerotic Plaques in the Aorta of ApoE[-/-] Mice via Macrophage Polarization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0PJC1;B2RQQ2;G5E8P2;Q69Z41;Q6DI55", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0060052 neurofilament cytoskeleton organization;GO:0021955 central nervous system neuron axonogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P97433-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55264-1", "uniprot_id": [ { "id": "ADK_MOUSE", "url": "https://www.uniprot.org/uniprot/P55264", "type": "external" } ], "mass": 40149.0, "length": 361, "protein_name": "Adenosine kinase", "gene_name": "Adk", "organism": "Mouse", "refseq_name": "adenosine kinase isoform 2", "refseq_ac": [ { "id": "NP_001229970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229970", "type": "external" } ], "gene_names_uniprotkb": "Adk", "gene_names_refseq": "2310026J05Rik; 5033405D03Rik; Adk; Ak", "protein_names_uniprotkb": "Adenosine kinase; 2.7.1.-; 2.7.1.20; AK; Adenosine 5'-phosphotransferase; N6,N6-dimethyladenosine kinase; N6-isopentenyladenosine kinase; N6-methyladenosine kinase", "protein_names_refseq": "N6,N6-dimethyladenosine kinase; N6-isopentenyladenosine kinase; N6-methyladenosine kinase; adenosine 5'-phosphotransferase; adenosine kinase isoform 2", "tax_id": 10090, "disease": "hypermethioninemia due to adenosine kinase deficiency (Disease Ontology:DOID:0111038); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:11534); (R-MMU-74217); (R-MMU-9755088)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "11997462;15317590;19224205;20173027;21750661;25428506;27903722;30084848;32152506;34203471;34428180;36210013;36288343;37453647;37507081;37828378;38699782;39927985;40840445;6407470;8917457", "class_list": "", "function": "ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives., [UniProtKB, UniProtKB, UniProtKB]; Adenosine kinase inhibits beta-cell proliferation by upregulating DNA methyltransferase 3A expression., [RefSeq, PubMed]; Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines (PubMed:15317590, PubMed:6407470). Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification (PubMed:40840445). Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction (PubMed:40840445). Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL (PubMed:40840445)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6JAM3;Q91VJ3", "ec_number_list": [ { "id": "2.7.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.20", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004001 adenosine kinase activity;GO:0004136 deoxyadenosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046085 adenosine metabolic process;GO:0032261 purine nucleotide salvage;GO:0006175 dATP biosynthetic process;GO:0044209 AMP salvage;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P55264-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNR9-1", "uniprot_id": [ { "id": "ARHG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNR9", "type": "external" } ], "mass": 56679.0, "length": 484, "protein_name": "Rho guanine nucleotide exchange factor 4", "gene_name": "Arhgef4", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 4 isoform 2", "refseq_ac": [ { "id": "NP_898840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898840", "type": "external" } ], "gene_names_uniprotkb": "Arhgef4; Kiaa1112", "gene_names_refseq": "9330140K16Rik; Arhgef4; Asef; C230030N03Rik", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 4; APC-stimulated guanine nucleotide exchange factor; Asef", "protein_names_refseq": "APC-stimulated guanine nucleotide exchange factor; Rho guanine nucleotide exchange factor (GEF) 4; Rho guanine nucleotide exhange factor 4; rho guanine nucleotide exchange factor 4 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226970)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10947987;19893577;21750661", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression., [UniProtKB, PubMed]; Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TJ6", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0032587 ruffle membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046847 filopodium assembly;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811L6-1", "uniprot_id": [ { "id": "MAST4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811L6", "type": "external" } ], "mass": 284004.0, "length": 2618, "protein_name": "Microtubule-associated serine/threonine-protein kinase 4", "gene_name": "Mast4", "organism": "Mouse", "refseq_name": "microtubule-associated serine/threonine-protein kinase 4", "refseq_ac": [ { "id": "NP_780380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780380", "type": "external" } ], "gene_names_uniprotkb": "Mast4", "gene_names_refseq": "4930420O11Rik; Mast4; mKIAA0303", "protein_names_uniprotkb": "Microtubule-associated serine/threonine-protein kinase 4; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 4", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457)", "pathway": " (mmu:328329)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "20173027;21183079;21750661;22517741;22645316;23443134;25428506;26192747;30084848;30779550;31219806;31599954;32782141;34428180;35803931;36592615;37828378;38945953;40021952;40885482;9119401", "class_list": "", "function": "MAST4 controls cell cycle in spermatogonial stem cells., [RefSeq, PubMed]; MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis., [RefSeq, PubMed]; Mast4 determines the cell fate of MSCs for bone and cartilage development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "E9QAH7;Q3UVE7;Q62489;Q6ZQE0;Q8BME3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q811L6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGD0-1", "uniprot_id": [ { "id": "ARAID_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGD0", "type": "external" } ], "mass": 23858.0, "length": 223, "protein_name": "All-trans retinoic acid-induced differentiation factor", "gene_name": "Atraid", "organism": "Mouse", "refseq_name": "all-trans retinoic acid-induced differentiation factor isoform 1 precursor", "refseq_ac": [ { "id": "NP_082131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082131", "type": "external" } ], "gene_names_uniprotkb": "Atraid; Apr3", "gene_names_refseq": "0610007C21Rik; Apr3; Atraid; HSPC013; p18", "protein_names_uniprotkb": "All-trans retinoic acid-induced differentiation factor; APR-3; Apoptosis-related protein 3", "protein_names_refseq": "H1E6 protein; all-trans retinoic acid-induced differentiation factor isoform 1 precursor; apoptosis related protein APR-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381629)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;29745899;30084848", "class_list": "", "function": "Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway (By similarity). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAH4;Q810Q3;Q9DD14", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0030154 cell differentiation;GO:0030501 positive regulation of bone mineralization;GO:0006855 xenobiotic transmembrane transport;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PGD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFY7-1", "uniprot_id": [ { "id": "5NT3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFY7", "type": "external" } ], "mass": 34425.0, "length": 300, "protein_name": "7-methylguanosine phosphate-specific 5'-nucleotidase", "gene_name": "Nt5c3b", "organism": "Mouse", "refseq_name": "7-methylguanosine phosphate-specific 5'-nucleotidase isoform 1", "refseq_ac": [ { "id": "NP_001096120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096120", "type": "external" } ], "gene_names_uniprotkb": "Nt5c3b; Nt5c3l", "gene_names_refseq": "2610037D24Rik; C330027I04Rik; Nt5c3b; Nt5c3l", "protein_names_uniprotkb": "7-methylguanosine phosphate-specific 5'-nucleotidase; 3.1.3.5; 3.1.3.91; 7-methylguanosine nucleotidase; Cytosolic 5'-nucleotidase 3B; Cytosolic 5'-nucleotidase III-like protein; N(7)-methylguanylate 5'-phosphatase; cN-III-like protein", "protein_names_refseq": "5'-nucleotidase, cytosolic III-like; 7-methylguanosine nucleotidase; 7-methylguanosine phosphate-specific 5'-nucleotidase isoform 1; 7-methylguanosine phosphate-specific 5'-nucleotidase; N(7)-methylguanylate 5'-phosphatase; cN-III-like protein; cytosolic 5'-nucleotidase 3B; cytosolic 5'-nucleotidase III-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68106); (R-MMU-429958)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4I2;A2A4I3;Q3TLP3;Q8BHU9;Q91WE8;Q9D9F9", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UFY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32304-1", "uniprot_id": [ { "id": "5HT7R_MOUSE", "url": "https://www.uniprot.org/uniprot/P32304", "type": "external" } ], "mass": 49916.0, "length": 448, "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "Htr7", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 7 isoform 1", "refseq_ac": [ { "id": "NP_032341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341", "type": "external" } ], "gene_names_uniprotkb": "Htr7", "gene_names_refseq": "5-HT-X; 5-HT7; Htr7", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X; 5-HT7; Serotonin receptor 7", "protein_names_refseq": "5-hydroxytryptamine receptor 7 isoform 1; 5-hydroxytryptamine receptor 7; serotonin receptor 7", "tax_id": 10090, "disease": "amnestic disorder (Disease Ontology:DOID:10914); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); childhood absence epilepsy (Disease Ontology:DOID:1825); anxiety disorder (Disease Ontology:DOID:2030); migraine (Disease Ontology:DOID:6364); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:15566); (R-MMU-390666); (R-MMU-418555); (R-MMU-9706019)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "18793707;21750661;8394987", "class_list": "", "function": "Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain are reported., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8394987). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14A50", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007613 memory;GO:0010976 positive regulation of neuron projection development;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007210 serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P32304-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571I9-1", "uniprot_id": [ { "id": "A16A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571I9", "type": "external" } ], "mass": 84756.0, "length": 802, "protein_name": "Aldehyde dehydrogenase family 16 member A1", "gene_name": "Aldh16a1", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase family 16 member A1", "refseq_ac": [ { "id": "NP_666066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666066", "type": "external" } ], "gene_names_uniprotkb": "Aldh16a1", "gene_names_refseq": "2410004H02Rik; Aldh16a1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 16 member A1", "protein_names_refseq": "aldehyde dehydrogenase family 16 member A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69748)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;26495903;28254523;30084848;34428180;39627609", "class_list": "", "function": "ALDH16A1 is expressed in proximal and distal convoluted tubule cells in the cortex of the kidney and in zone 3 hepatocytes. RNA-seq and gene ontology enrichment analyses showed that cellular lipid and lipid metabolic processes are up-regulated., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6I2;Q3UMC3;Q8C0L4;Q8VD78", "ec_number_list": [], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q571I9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68G58-1", "uniprot_id": [ { "id": "APEX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68G58", "type": "external" } ], "mass": 57340.0, "length": 516, "protein_name": "DNA-(apurinic or apyrimidinic site) endonuclease 2", "gene_name": "Apex2", "organism": "Mouse", "refseq_name": "DNA-(apurinic or apyrimidinic site) endonuclease 2", "refseq_ac": [ { "id": "NP_084219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084219", "type": "external" } ], "gene_names_uniprotkb": "Apex2; Ape2", "gene_names_refseq": "Apex2; C430040P13Rik; ape2", "protein_names_uniprotkb": "DNA-(apurinic or apyrimidinic site) endonuclease 2; 3.1.11.2; AP endonuclease 2; APEX nuclease 2; Apurinic-apyrimidinic endonuclease 2", "protein_names_refseq": "AP endonuclease 2; APEX nuclease 2; DNA-(apurinic or apyrimidinic site) endonuclease 2; DNA-(apurinic or apyrimidinic site) lyase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77622)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12573260;15319281;18025127;18585982;19556307;21750661;24935922;25158232;31219806;34428180;35098924;37074207", "class_list": "", "function": "APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1., [RefSeq, PubMed]; APEX2 is required for proper cell cycle progression of proliferating lymphocytes., [RefSeq, PubMed]; Apex2 is required for efficient somatic hypermutation of immunoglobulin genes., [RefSeq, PubMed]; Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination. Erratum:[J Exp Med. 2007 Dec 24;204(13):3295], [RefSeq, PubMed]; Expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (By similarity). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity). Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (By similarity). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway (By similarity). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (By similarity). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (PubMed:18025127, PubMed:19556307). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (PubMed:15319281)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends., [UniProtKB, UniProtKB, UniProtKB]; May participate in postreplicative base excision repair, [RefSeq, PubMed]; Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage., [RefSeq, PubMed]; Subcellular proteomics of dopamine neurons in the mouse brain. Publication Status: Online-Only, [RefSeq, PubMed]; The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJP7;Q8BTR7;Q8BUZ2;Q8BYE9;Q8R018;Q8R328;Q9CS12", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0006310 DNA recombination;GO:0006284 base-excision repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q68G58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CSB4-1", "uniprot_id": [ { "id": "PAR3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CSB4", "type": "external" } ], "mass": 132780.0, "length": 1203, "protein_name": "Partitioning defective 3 homolog B", "gene_name": "Pard3b", "organism": "Mouse", "refseq_name": "partitioning defective 3 homolog B", "refseq_ac": [ { "id": "NP_001074519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074519", "type": "external" } ], "gene_names_uniprotkb": "Pard3b; Als2cr19; Par3l", "gene_names_refseq": "1810008K04Rik; 2010002N16Rik; 2810455B10Rik; Als2cr19; PAR3B; PAR3L; PAR3beta; Pard3b", "protein_names_uniprotkb": "Partitioning defective 3 homolog B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog; PAR3-L protein; PAR3-beta; Partitioning defective 3-like protein", "protein_names_refseq": "PAR3-L protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog; par-3 partitioning defective 3 homolog B; partitioning defective 3 homolog B; partitioning defective 3-like protein", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:72823)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;24305829", "class_list": "", "function": "Atp6ap2/(P)RR interacted with partitioning defective 3 homolog (PAR3) protein, which is known to function in the Par-atypical protein kinase C, [RefSeq, PubMed]; Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SV53", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0005938 cell cortex;GO:0030054 cell junction;GO:0012505 endomembrane system", "go_biological_process": "GO:0007155 cell adhesion;GO:0051301 cell division;GO:0008104 intracellular protein localization;GO:0000226 microtubule cytoskeleton organization;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CSB4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4S1-1", "uniprot_id": [ { "id": "PDE8B_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4S1", "type": "external" } ], "mass": 96739.0, "length": 865, "protein_name": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B", "gene_name": "Pde8b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pde8b", "gene_names_refseq": "", "protein_names_uniprotkb": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; 3.1.4.53; Cell proliferation-inducing gene 22 protein; PDE8B", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary pigmented nodular adrenocortical disease 3 (Disease Ontology:DOID:0070548)", "pathway": " (mmu:218461); (R-MMU-418555)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;18431404;21183079;21750661", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0035106 operant conditioning;GO:0090032 negative regulation of steroid hormone biosynthetic process;GO:0007165 signal transduction;GO:0008542 visual learning;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q4S1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55057-1", "uniprot_id": [ { "id": "PDE6D_MOUSE", "url": "https://www.uniprot.org/uniprot/O55057", "type": "external" } ], "mass": 17348.0, "length": 150, "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "Pde6d", "organism": "Mouse", "refseq_name": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 1", "refseq_ac": [ { "id": "NP_032827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032827", "type": "external" } ], "gene_names_uniprotkb": "Pde6d", "gene_names_refseq": "Pde6d; PrBP/delta", "protein_names_uniprotkb": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; GMP-PDE delta", "protein_names_refseq": "GMP-PDE delta; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 1; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "tax_id": 10090, "disease": "Joubert syndrome 22 (Disease Ontology:DOID:0110991)", "pathway": " (mmu:18582); (R-MMU-5624958); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10518933;15979089;21750661;22179043;27063844;29140789;30228185;9570951;9781033;9990021", "class_list": "", "function": "It postulates a three-step mechanism regulating ciliary localization of INPP5E, consisting of farnesylation- and PDE6delta-mediated targeting, INPP5E-PDE6delta complex diffusion into the cilium with transfer to the IFT system, and retention inside cilia., [RefSeq, PubMed]; Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Required for RAB28 localization to the cone cell outer segments in the retina (PubMed:30228185). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The affinity to PDE6delta and the release by Arl2/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005095 GTPase inhibitor activity;GO:0031267 small GTPase binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O55057-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35386-1", "uniprot_id": [ { "id": "PAHX_MOUSE", "url": "https://www.uniprot.org/uniprot/O35386", "type": "external" } ], "mass": 38607.0, "length": 338, "protein_name": "Phytanoyl-CoA dioxygenase, peroxisomal", "gene_name": "Phyh", "organism": "Mouse", "refseq_name": "phytanoyl-CoA dioxygenase, peroxisomal precursor", "refseq_ac": [ { "id": "NP_034856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034856", "type": "external" } ], "gene_names_uniprotkb": "Phyh; Ln1; Lnap1; Pahx", "gene_names_refseq": "Lnap1; PAHX; Phyh", "protein_names_uniprotkb": "Phytanoyl-CoA dioxygenase, peroxisomal; 1.14.11.18; Lupus nephritis-associated peptide 1; PhyH; Phytanic acid oxidase; Phytanoyl-CoA alpha-hydroxylase", "protein_names_refseq": "lupus nephritis-associated peptide 1; phytanic acid oxidase; phytanoyl-CoA alpha-hydroxylase; phytanoyl-CoA dioxygenase, peroxisomal precursor; phytanoyl-CoA dioxygenase, peroxisomal", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Refsum disease (Disease Ontology:DOID:10582); Zellweger syndrome (Disease Ontology:DOID:905); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (mmu:16922); (R-MMU-389599); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10686344;23806337;31219806;34428180;37453647;8954131;9326939", "class_list": "", "function": "Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08527", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0003824 catalytic activity;GO:0031406 carboxylic acid binding;GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0048244 phytanoyl-CoA dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0001561 fatty acid alpha-oxidation;GO:0006720 isoprenoid metabolic process;GO:0097089 methyl-branched fatty acid metabolic process;GO:0019606 2-oxobutyrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35386-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60335-1", "uniprot_id": [ { "id": "PCBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P60335", "type": "external" } ], "mass": 37498.0, "length": 356, "protein_name": "Poly(rC)-binding protein 1", "gene_name": "Pcbp1", "organism": "Mouse", "refseq_name": "poly(rC)-binding protein 1", "refseq_ac": [ { "id": "NP_035995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035995", "type": "external" } ], "gene_names_uniprotkb": "Pcbp1", "gene_names_refseq": "Pcbp1; WBP17; [a]CP-1; alphaCP-1; hnRNP E1; hnRNP-E1", "protein_names_uniprotkb": "Poly(rC)-binding protein 1; Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; hnRNP E1", "protein_names_refseq": "alpha-CP1; heterogeneous nuclear ribonucleoprotein E1; poly(rC)-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23983); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10455157;19131326;20484733;21183079;22645316;24788674;25153642;25389050;25428506;26527618;26740625;28135057;30084848;30779550;33725478;34180713;34428180;34678516;35639300;35820727;36288343;36702545;37453647;37507081;37558923;39627609", "class_list": "", "function": "Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program., [RefSeq, PubMed]; PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon., [RefSeq, PubMed]; PCBP1-mediated regulation of WNT signaling is critical for breast tumorigenesis., [RefSeq, PubMed]; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (PubMed:34180713)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051604 protein maturation;GO:0039694 viral RNA genome replication", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P60335-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q50L42-1", "uniprot_id": [ { "id": "PA24E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q50L42", "type": "external" } ], "mass": 100157.0, "length": 875, "protein_name": "Cytosolic phospholipase A2 epsilon", "gene_name": "Pla2g4e", "organism": "Mouse", "refseq_name": "cytosolic phospholipase A2 epsilon isoform 1", "refseq_ac": [ { "id": "NP_808513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808513", "type": "external" } ], "gene_names_uniprotkb": "Pla2g4e", "gene_names_refseq": "2310026J01Rik; C230096D22; Pla2epsilon; Pla2g4e", "protein_names_uniprotkb": "Cytosolic phospholipase A2 epsilon; 3.1.1.4; Calcium-dependent N-acyltransferase; Phospholipase A2 group IVE; cPLA2-epsilon", "protein_names_refseq": "cPLA2-epsilon; calcium-dependent N-acyltransferase; cytosolic phospholipase A2 epsilon isoform 1; cytosolic phospholipase A2 epsilon; phospholipase A2, group 4E", "tax_id": 10090, "disease": "", "pathway": " (mmu:329502); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1483115)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "15866882;21183079;24413173;27399000;29447909", "class_list": "", "function": "Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:27399000). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:27399000, PubMed:29447909). Has weak phospholipase A2 and lysophospholipase activities (PubMed:15866882, PubMed:27399000). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (PubMed:24413173)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX44", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:2001137 positive regulation of endocytic recycling;GO:0070292 N-acylphosphatidylethanolamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q50L42-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET54-1", "uniprot_id": [ { "id": "PALLD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET54", "type": "external" } ], "mass": 152131.0, "length": 1408, "protein_name": "Palladin", "gene_name": "Palld", "organism": "Mouse", "refseq_name": "palladin isoform 4", "refseq_ac": [ { "id": "NP_001074859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074859", "type": "external" } ], "gene_names_uniprotkb": "Palld; Kiaa0992", "gene_names_refseq": "2410003B16Rik; 6030492A02; Palld", "protein_names_uniprotkb": "Palladin", "protein_names_refseq": "90kDa actin-associated protein palladin; palladin isoform 4", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (mmu:72333)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10931874;11438925;14983521;15950489;16164966;16492705;16868024;17115415;17242355;17431131;18630941;21183079;21750661;22645316;24788674;28528544;30084848;31599954;32620172;32782141;34428180;34887587;36288343;36852467;36927816;37712274;40997131", "class_list": "", "function": "Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities. Publication Status: Online-Only, [RefSeq, PubMed]; Cloning and promoter analysis of palladin 90-kDa, 140-kDa, and 200-kDa isoforms involved in skeletal muscle cell maturation. Publication Status: Online-Only, [RefSeq, PubMed]; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular locations. May be required for the initiation of neural tube closure., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking., [RefSeq, PubMed]; [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0JNZ3;Q69ZT7;Q6DFX7;Q9CWW1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008092 cytoskeletal protein binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005884 actin filament", "go_biological_process": "GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0050808 synapse organization;GO:0030036 actin cytoskeleton organization;GO:0003334 keratinocyte development", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q9ET54-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0P4-1", "uniprot_id": [ { "id": "PALM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0P4", "type": "external" } ], "mass": 41614.0, "length": 383, "protein_name": "Paralemmin-1", "gene_name": "Palm", "organism": "Mouse", "refseq_name": "paralemmin-1 isoform 2", "refseq_ac": [ { "id": "NP_001155219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155219", "type": "external" } ], "gene_names_uniprotkb": "Palm", "gene_names_refseq": "Palm", "protein_names_uniprotkb": "Paralemmin-1; Paralemmin", "protein_names_refseq": "paralemmin-1 isoform 2; paralemmin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18483)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17114649;17242355;18287537;21183079;21750661;32848054;34428180;40885482;9813098", "class_list": "", "function": "Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0P3", "ec_number_list": [], "go_molecular_function": "GO:0031750 D3 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0060160 negative regulation of dopamine receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0072659 protein localization to plasma membrane;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z0P4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LX0-1", "uniprot_id": [ { "id": "PARK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LX0", "type": "external" } ], "mass": 20021.0, "length": 189, "protein_name": "Parkinson disease protein 7 homolog", "gene_name": "Park7", "organism": "Mouse", "refseq_name": "Parkinson disease protein 7 homolog", "refseq_ac": [ { "id": "NP_065594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065594", "type": "external" } ], "gene_names_uniprotkb": "Park7", "gene_names_refseq": "DJ-1; Dj1; Park7", "protein_names_uniprotkb": "Parkinson disease protein 7 homolog; 3.1.2.-; 3.5.1.-; 3.5.1.124; DJ-1; Maillard deglycase; Parkinsonism-associated deglycase; Protein DJ-1; Protein/nucleic acid deglycase DJ-1", "protein_names_refseq": "Parkinson disease protein 7 homolog; RNA-binding protein regulatory subunit; maillard deglycase; parkinsonism-associated deglycase; protein DJ-1; protein deglycase DJ-1; protein/nucleic acid deglycase DJ-1", "tax_id": 10090, "disease": "Parkinson's disease 7 (Disease Ontology:DOID:0060370); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:57320); (R-MMU-3899300); (R-MMU-9646399)", "pathway_count": 3, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;11223268;11811539;12132656;14749723;15784737;17015834;17766438;19276172;20186336;20800516;21068725;21097510;21750661;22523093;22555455;22611253;23792957;23806337;23847046;26021615;26422139;26495903;31219806;31536960;34428180;35820727;36288343;37453647;37507081;37828378;38310161;38380563;38460098;39927985", "class_list": "", "function": "CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation., [RefSeq, PubMed]; DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin, [RefSeq, PubMed]; DJ-1 participates in the fertilization, [RefSeq, PubMed]; DJ-1 protects cell death from a mitochondrial oxidative stress due to GBA1 deficiency., [RefSeq, PubMed]; Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:15784737, PubMed:17015834, PubMed:20800516, PubMed:21068725). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:17015834, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels. Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:17766438). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:20186336). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:21068725). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:19276172, PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (PubMed:26422139). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (By similarity). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (PubMed:26021615)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; N-homocysteinylation of DJ-1 promotes neurodegeneration in Parkinson's disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88306;Q3THB9;Q3U509", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:1990422 glyoxalase (glycolic acid-forming) activity;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0061727 methylglyoxal catabolic process to lactate;GO:0140041 cellular detoxification of methylglyoxal;GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q99LX0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERE7-1", "uniprot_id": [ { "id": "MESD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERE7", "type": "external" } ], "mass": 25207.0, "length": 224, "protein_name": "LRP chaperone MESD", "gene_name": "Mesd", "organism": "Mouse", "refseq_name": "LRP chaperone MESD isoform 1 precursor", "refseq_ac": [ { "id": "NP_075892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075892", "type": "external" } ], "gene_names_uniprotkb": "Mesd; Mesdc2", "gene_names_refseq": "2210015O11Rik; Mesdc2; Mesd; mKIAA0081; msd", "protein_names_uniprotkb": "LRP chaperone MESD; LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein", "protein_names_refseq": "LDLR chaperone MESD; LRP chaperone MESD isoform 1 precursor; LRP chaperone MESD; mesoderm development candidate 2", "tax_id": 10090, "disease": "osteogenesis imperfecta type 20 (Disease Ontology:DOID:0111849)", "pathway": " (mmu:67943)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11247670;12581525;17342452;20506034;21375506;21397183;21397184;21397185;21750661;24140340;27184668;31564437", "class_list": "", "function": "Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mescd2 binds to Lrp4 and regulates Lrp4 surface expression in myotubes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C611;Q8CCX7;Q91WK8;Q9CVB9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0072659 protein localization to plasma membrane;GO:0006909 phagocytosis;GO:0006457 protein folding;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ERE7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27546-1", "uniprot_id": [ { "id": "MAP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P27546", "type": "external" } ], "mass": 117429.0, "length": 1125, "protein_name": "Microtubule-associated protein 4", "gene_name": "Map4", "organism": "Mouse", "refseq_name": "microtubule-associated protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001192259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192259", "type": "external" } ], "gene_names_uniprotkb": "Map4; Mtap4", "gene_names_refseq": "MAP-4; Map4; Mtap-4; Mtap4", "protein_names_uniprotkb": "Microtubule-associated protein 4; MAP-4", "protein_names_refseq": "MAP 4; microtubule-associated protein 4 isoform 1", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332); tauopathy (Disease Ontology:DOID:680)", "pathway": " (mmu:17758)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16452087;1718985;17242355;19131326;19144319;21183079;21750661;21952136;22517741;22645316;25153642;25428506;26487268;26495903;28135057;29187734;30084848;30327268;30906793;31219806;34428180;35902952;36288343;36835542;39927985;40684658", "class_list": "", "function": "MiR-103-3p Regulates the Differentiation and Autophagy of Myoblasts by Targeting MAP4. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; Non-neuronal microtubule-associated protein. Promotes microtubule assembly., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q05BJ2;Q3UIS2;Q3UUH5;Q3UY36;Q7TPC6;Q7TPD4;Q80YQ5;Q8CFP5", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0140778 microtubule stabilizing activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0014069 postsynaptic density", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051294 establishment of spindle orientation;GO:0031175 neuron projection development;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P27546-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHU2-1", "uniprot_id": [ { "id": "PALMD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHU2", "type": "external" } ], "mass": 62700.0, "length": 551, "protein_name": "Palmdelphin", "gene_name": "Palmd", "organism": "Mouse", "refseq_name": "palmdelphin", "refseq_ac": [ { "id": "NP_075734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075734", "type": "external" } ], "gene_names_uniprotkb": "Palmd", "gene_names_refseq": "4631423C22Rik; PALML; Palmd", "protein_names_uniprotkb": "Palmdelphin", "protein_names_refseq": "palmdelphin; paralemmin-related", "tax_id": 10090, "disease": "", "pathway": " (mmu:114301)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11478809;11707320;16323283;17242355;21183079;21750661;34428180;34636652;36288343", "class_list": "", "function": "Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAG0;Q91X00;Q9D693", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JHU2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4LDD4-1", "uniprot_id": [ { "id": "ARAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4LDD4", "type": "external" } ], "mass": 162276.0, "length": 1452, "protein_name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1", "gene_name": "Arap1", "organism": "Mouse", "refseq_name": "arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001035200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035200", "type": "external" } ], "gene_names_uniprotkb": "Arap1; Centd2; Kiaa0782", "gene_names_refseq": "2410002L19Rik; Arap1; Centd2; mKIAA0782", "protein_names_uniprotkb": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; Centaurin-delta-2; Cnt-d2", "protein_names_refseq": "arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform 3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; centaurin, delta 2; cnt-d2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69710); (R-MMU-8849469); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "19589776;21183079;21750661;28324111;29589748;30240610;31219806;34428180;35758026;36803446", "class_list": "", "function": "Afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1., [RefSeq, PubMed]; Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death., [RefSeq, PubMed]; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (By similarity). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (By similarity). Has a preference for ARF1 and ARF5 (By similarity). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (By similarity). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (PubMed:30240610). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (PubMed:30240610). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (PubMed:30240610). Regulates the endocytic trafficking of EGFR (By similarity). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (By similarity). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (PubMed:28324111, PubMed:35758026)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RUJ3;Q3UDD2;Q3US99;Q58ET6;Q6PEQ9;Q6ZQ48", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0005096 GTPase activator activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0031344 regulation of cell projection organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0043547 positive regulation of GTPase activity;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4LDD4-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWA8-1", "uniprot_id": [ { "id": "ARHGJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWA8", "type": "external" } ], "mass": 88851.0, "length": 802, "protein_name": "Rho guanine nucleotide exchange factor 19", "gene_name": "Arhgef19", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 19", "refseq_ac": [ { "id": "NP_766108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766108", "type": "external" } ], "gene_names_uniprotkb": "Arhgef19; Wgef", "gene_names_refseq": "6030432F23; 6430573B13Rik; Arhgef19; WGEF", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 19; Ephexin-2; Weakly similar to Rho GEF 5", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 19; ephexin-2; rho guanine nucleotide exchange factor 19; weakly similar to Rho GEF 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:213649); (R-MMU-193648); (R-MMU-416482); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "15485661;15848799;19503838;21750661;31219806;34428180", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase., [UniProtKB, PubMed]; Adipogenesis is regulated by WGEF expression through DNA methylation change Publication Status: Online-Only, [RefSeq, PubMed]; WGEF is a RhoGEF expressed in intestine, liver, heart, and kidney, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAC2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0043547 positive regulation of GTPase activity;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BWA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16110-1", "uniprot_id": [ { "id": "LEG3_MOUSE", "url": "https://www.uniprot.org/uniprot/P16110", "type": "external" } ], "mass": 27515.0, "length": 264, "protein_name": "Galectin-3", "gene_name": "Lgals3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lgals3", "gene_names_refseq": "", "protein_names_uniprotkb": "Galectin-3; 35 kDa lectin; CBP 35; Carbohydrate-binding protein 35; Gal-3; Galactose-specific lectin 3; IgE-binding protein; L-34 galactoside-binding lectin; Laminin-binding protein; Lectin L-29; Mac-2 antigen", "protein_names_refseq": "", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); aortic valve stenosis (Disease Ontology:DOID:1712); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082); congestive heart failure (Disease Ontology:DOID:6000); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-MMU-6798695)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10745073;14961764;15181153;16473834;1917966;21750661;2332426;2525069;2584931;30084848;3360772;34428180;35984892;37453647;37507081", "class_list": "glycogene", "function": "Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration (PubMed:15181153). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes (By similarity). When secreted, interacts with NK cell-activating receptor NCR3/NKp30 acting as an inhibitory ligand which antagonizes NK cell attack (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0030547 signaling receptor inhibitor activity;GO:0019863 IgE binding;GO:0050785 advanced glycation end-product receptor activity;GO:0042056 chemoattractant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0070232 regulation of T cell apoptotic process;GO:0071677 positive regulation of mononuclear cell migration;GO:0045806 negative regulation of endocytosis;GO:0006397 mRNA processing;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P16110-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z110-1", "uniprot_id": [ { "id": "P5CS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z110", "type": "external" } ], "mass": 87266.0, "length": 795, "protein_name": "Delta-1-pyrroline-5-carboxylate synthase", "gene_name": "Aldh18a1", "organism": "Mouse", "refseq_name": "delta-1-pyrroline-5-carboxylate synthase isoform 1", "refseq_ac": [ { "id": "NP_062672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062672", "type": "external" } ], "gene_names_uniprotkb": "Aldh18a1; P5cs; Pycs", "gene_names_refseq": "2810433K04Rik; Aldh18a1; Pycs", "protein_names_uniprotkb": "Delta-1-pyrroline-5-carboxylate synthase; Aldehyde dehydrogenase family 18 member A1; Gamma-glutamyl kinase; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; P5CS", "protein_names_refseq": "P5CS; aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthase isoform 1; delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)", "tax_id": 10090, "disease": "autosomal dominant cutis laxa 3 (Disease Ontology:DOID:0070131); autosomal recessive cutis laxa type IIIA (Disease Ontology:DOID:0070132); autosomal recessive cutis laxa type III (Disease Ontology:DOID:0070143); hereditary spastic paraplegia 9A (Disease Ontology:DOID:0110824); hereditary spastic paraplegia 9B (Disease Ontology:DOID:0110825); enterocele (Disease Ontology:DOID:1283); hereditary spastic paraplegia (Disease Ontology:DOID:2476); cataract (Disease Ontology:DOID:83); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:56454); (R-MMU-8964539); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10037775;21750661;22645316;23806337;24788674;25153642;28528544;31219806;39506109;39627609;40684658", "class_list": "", "function": "Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGM2;Q9R1P6", "ec_number_list": [ { "id": "1.2.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.41", "type": "external" }, { "id": "2.7.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004349 glutamate 5-kinase activity;GO:0004350 glutamate-5-semialdehyde dehydrogenase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0019240 citrulline biosynthetic process;GO:0006536 glutamate metabolic process;GO:0008652 amino acid biosynthetic process;GO:0009266 response to temperature stimulus;GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z110-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08030-1", "uniprot_id": [ { "id": "APT_MOUSE", "url": "https://www.uniprot.org/uniprot/P08030", "type": "external" } ], "mass": 19724.0, "length": 180, "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "Aprt", "organism": "Mouse", "refseq_name": "adenine phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_033828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033828", "type": "external" } ], "gene_names_uniprotkb": "Aprt", "gene_names_refseq": "Aprt", "protein_names_uniprotkb": "Adenine phosphoribosyltransferase; 2.4.2.7; APRT", "protein_names_refseq": "adenine phosphoribosyltransferase", "tax_id": 10090, "disease": "adenine phosphoribosyltransferase deficiency (Disease Ontology:DOID:0060350); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:11821); (R-MMU-6798695); (R-MMU-74217)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "19131326;21750661;25428506;25605945;27802388;33675115;37828378;3921964;8433377;8906823", "class_list": "", "function": "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis., [UniProtKB, UniProtKB]; Modulation of adenine phosphoribosyltransferase-mediated salvage pathway to accelerate diabetic wound healing., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q564P4;Q61319;Q6PK77;Q9DCY3", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" } ], "go_molecular_function": "GO:0016208 AMP binding;GO:0002055 adenine binding;GO:0003999 adenine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0044209 AMP salvage;GO:0007595 lactation;GO:0032264 IMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0006168 adenine salvage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08030-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70331-1", "uniprot_id": [ { "id": "MDFI_MOUSE", "url": "https://www.uniprot.org/uniprot/P70331", "type": "external" } ], "mass": 26013.0, "length": 251, "protein_name": "MyoD family inhibitor", "gene_name": "Mdfi", "organism": "Mouse", "refseq_name": "myoD family inhibitor isoform 1", "refseq_ac": [ { "id": "NP_001103443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103443", "type": "external" } ], "gene_names_uniprotkb": "Mdfi", "gene_names_refseq": "I-mfa; I-mf; Mdfi", "protein_names_uniprotkb": "MyoD family inhibitor; Myogenic repressor I-mf", "protein_names_refseq": "myoD family inhibitor isoform 1; myogenic repressor I-mf", "tax_id": 10090, "disease": "", "pathway": " (mmu:17240)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11238923;12192039;21750661;31984795;34428180;37267696;37590348;8797820;9799236", "class_list": "", "function": "Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis (PubMed:8797820). Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals (PubMed:8797820). Can also interfere with the DNA-binding activity of Myod family members (PubMed:8797820). Plays an important role in trophoblast and chondrogenic differentiation (PubMed:9799236). Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with Tcf7l1/Tcf3 and preventing it from binding DNA (PubMed:11238923). Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation., [RefSeq, PubMed]; These results suggest that I-mfa, increased by high glucose/diabetes through the production of reactive oxygen species, stimulates fibronectin production by mesangial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70330;P70332;Q5XK64;Q99JM9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0140297 DNA-binding transcription factor binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0030111 regulation of Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70331-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGB6-1", "uniprot_id": [ { "id": "TENS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGB6", "type": "external" } ], "mass": 152013.0, "length": 1400, "protein_name": "Tensin-2", "gene_name": "Tns2", "organism": "Mouse", "refseq_name": "tensin-2 isoform 1", "refseq_ac": [ { "id": "NP_705761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705761", "type": "external" } ], "gene_names_uniprotkb": "Tns2; Tenc1", "gene_names_refseq": "C1-ten; Tenc1; Tns2; nep; nph", "protein_names_uniprotkb": "Tensin-2; 3.1.3.48; C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-like C1 domain-containing phosphatase", "protein_names_refseq": "C1 domain-containing phosphatase and tensin homolog; C1 domain-containing phosphatase and tensin-like protein; tensin-2 isoform 1; tensin-like C1 domain-containing phosphatase", "tax_id": 10090, "disease": "Pierson syndrome (Disease Ontology:DOID:0060852)", "pathway": " (mmu:209039)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "15592455;17242355;19131326;21183079;21750661;23401856;24129315;27246398;28955049;31219806;31616917;31723089;32390516;32782141;34428180;34678516;40885482", "class_list": "", "function": "Deficiency causes alteration of actin remodeling and morphological changes in podocytes and subsequent proteinuria, [RefSeq, PubMed]; Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier., [RefSeq, PubMed]; Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (By similarity). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (By similarity). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation (By similarity). Dephosphorylates nephrin NPHS1 in podocytes which affects mTORC1 complex activity (By similarity). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (By similarity). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (PubMed:27246398, PubMed:31723089, PubMed:32390516). Enhances RHOA activation in the presence of DLC1 (By similarity). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ93;Q3UGR8;Q8CJ95;Q8R122", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0019725 cellular homeostasis;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8CGB6-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKI2-1", "uniprot_id": [ { "id": "TNR6B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKI2", "type": "external" } ], "mass": 191963.0, "length": 1810, "protein_name": "Trinucleotide repeat-containing gene 6B protein", "gene_name": "Tnrc6b", "organism": "Mouse", "refseq_name": "trinucleotide repeat-containing gene 6B protein isoform 1", "refseq_ac": [ { "id": "NP_659061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659061", "type": "external" } ], "gene_names_uniprotkb": "Tnrc6b; Kiaa1093", "gene_names_refseq": "2700090M07Rik; A730065C02Rik; D230019K20Rik; Tnrc6b", "protein_names_uniprotkb": "Trinucleotide repeat-containing gene 6B protein", "protein_names_refseq": "trinucleotide repeat-containing gene 6B protein isoform 1; trinucleotide repeat-containing gene 6B protein", "tax_id": 10090, "disease": "uterine fibroid (Disease Ontology:DOID:13223); subserous uterine fibroid (Disease Ontology:DOID:13560)", "pathway": " (mmu:213988); (R-MMU-426496)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25428506;29237092;31219806;32782141;32848054;34428180;36852467;40885482", "class_list": "", "function": "Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "Q80TK4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0035278 miRNA-mediated gene silencing by inhibition of translation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0035195 miRNA-mediated post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q8BKI2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPQ3-1", "uniprot_id": [ { "id": "TOM22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPQ3", "type": "external" } ], "mass": 15537.0, "length": 142, "protein_name": "Mitochondrial import receptor subunit TOM22 homolog", "gene_name": "Tomm22", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM22 homolog", "refseq_ac": [ { "id": "NP_766197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766197", "type": "external" } ], "gene_names_uniprotkb": "Tomm22; Tom22", "gene_names_refseq": "2310047D01; Tom22; Tomm22", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM22 homolog; Translocase of outer membrane 22 kDa subunit homolog", "protein_names_refseq": "mitochondrial import receptor subunit TOM22 homolog; translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:223696); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;26787839;29165030;34428180;36288343", "class_list": "", "function": "Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data show that mammalian CSNK2-dependent phosphorylation of TOMM22 is a critical switch for mitophagy and reveal CSNK2-dependent physiological implications on metabolism, muscle integrity and behavior., [RefSeq, PubMed]; Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543M4;Q9D8D3", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005742 mitochondrial outer membrane translocase complex;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043065 positive regulation of apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix;GO:0051204 protein insertion into mitochondrial membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CPQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922S4-1", "uniprot_id": [ { "id": "PDE2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922S4", "type": "external" } ], "mass": 105619.0, "length": 939, "protein_name": "cGMP-dependent 3',5'-cyclic phosphodiesterase", "gene_name": "Pde2a", "organism": "Mouse", "refseq_name": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2", "refseq_ac": [ { "id": "NP_001137321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137321", "type": "external" } ], "gene_names_uniprotkb": "Pde2a", "gene_names_refseq": "CGS-PDE; Pde2a; cGSPDE", "protein_names_uniprotkb": "cGMP-dependent 3',5'-cyclic phosphodiesterase; 3.1.4.17; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; cGSPDE", "protein_names_refseq": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2; cGMP-dependent 3',5'-cyclic phosphodiesterase; cyclic GMP-stimulated phosphodiesterase", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (mmu:207728); (R-MMU-418457); (R-MMU-418555)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12271124;15210692;18299400;21724846;21750661;28463107;33300544;34428180;38154608;38159569;38395995;39627609", "class_list": "", "function": "CGMP binding to PDE2 GAF-B activates the enzyme rapidly, stoichiometrically, and in an all or none fashion, rather than variably over a large range of cyclic nucleotide concentrations, [RefSeq, PubMed]; Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a., [RefSeq, PubMed]; Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates mitochondrial cAMP levels and respiration (PubMed:21724846). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107)., [UniProtKB, PubMed, PubMed]; Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L., [UniProtKB, UniProtKB]; The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling., [RefSeq, PubMed]; cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:21724846). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCR8;Q3TXZ6;Q8K2U1", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097457 hippocampal mossy fiber;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0003170 heart valve development;GO:0061028 establishment of endothelial barrier;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q922S4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60996-1", "uniprot_id": [ { "id": "2A5G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60996", "type": "external" } ], "mass": 60824.0, "length": 524, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform", "gene_name": "Ppp2r5c", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b", "refseq_ac": [ { "id": "NP_001074926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074926", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r5c", "gene_names_refseq": "2610043M05Rik; 2700063L20Rik; D12Bwg0916e; Ppp2r5c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; PP2A B subunit isoform B'-alpha-3; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma", "protein_names_refseq": "B56/PP2A gamma; Band 8A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:26931); (R-MMU-141430); (R-MMU-141444); (R-MMU-195253); (R-MMU-196299); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6804757); (R-MMU-6811558); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 18, "publication_count": 15, "publication_id_list": "12507892;15051958;21750661;25428506;28562161;30084848;30779550;31219806;34428180;36210013;37507081;39287443;39627609;8617797;8752144", "class_list": "", "function": "Inactivation of only the PP2A-B56gamma subunit can affect the efficiency of the spindle assembly checkpoint., [RefSeq, PubMed]; LincR-PPP2R5C deficiency enhancing the fungicidal activity of neutrophils in pulmonary cryptococcosis is linked to the upregulation of IL-4., [RefSeq, PubMed]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35708;Q6TQF7;Q99KW8;Q99N67;Q99N68", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0051177 meiotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60996-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ULD5-1", "uniprot_id": [ { "id": "MCCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ULD5", "type": "external" } ], "mass": 61379.0, "length": 563, "protein_name": "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "gene_name": "Mccc2", "organism": "Mouse", "refseq_name": "methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "refseq_ac": [ { "id": "NP_084302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084302", "type": "external" } ], "gene_names_uniprotkb": "Mccc2", "gene_names_refseq": "4930552N12Rik; MCCB; Mccc2", "protein_names_uniprotkb": "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 6.4.1.4; MCCase subunit beta", "protein_names_refseq": "3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; MCCase subunit beta; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "tax_id": 10090, "disease": "3-methylcrotonyl-CoA carboxylase 2 deficiency (Disease Ontology:DOID:0080580); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:78038); (R-MMU-196780); (R-MMU-70895)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;23576753;23806337;30084848;33300544;34428180;36288343;37453647", "class_list": "", "function": "Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPS6", "ec_number_list": [ { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004485 methylcrotonoyl-CoA carboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1905202 methylcrotonoyl-CoA carboxylase complex", "go_biological_process": "GO:0015936 coenzyme A metabolic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3ULD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT18-1", "uniprot_id": [ { "id": "MCAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT18", "type": "external" } ], "mass": 138593.0, "length": 1306, "protein_name": "Activating transcription factor 7-interacting protein 1", "gene_name": "Atf7ip", "organism": "Mouse", "refseq_name": "activating transcription factor 7-interacting protein 1 isoform 3", "refseq_ac": [ { "id": "NP_062299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062299", "type": "external" } ], "gene_names_uniprotkb": "Atf7ip; Mcaf1", "gene_names_refseq": "2610204M12Rik; 5830415B17Rik; AM; Atf7ip; Mcaf1", "protein_names_uniprotkb": "Activating transcription factor 7-interacting protein 1; ATFa-associated modulator; MBD1-containing chromatin-associated factor 1; mAM", "protein_names_refseq": "ATFa-associated Modulator; MBD1-containing chromatin-associated factor 1; activating transcription factor 7-interacting protein 1 isoform 3; activating transcription factor 7-interacting protein 1", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:54343); (R-MMU-3214841); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10777215;14536086;17242355;21183079;21606357;21750661;22517741;26495903;32782141;34418053;34428180;34678516;35820727;36210013;36852467;36901736;40885482;40997131", "class_list": "", "function": "Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor. Publication Status: Online-Only, [RefSeq, PubMed]; MAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1, [RefSeq, PubMed]; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context (PubMed:10777215). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 28, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 28, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 28, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 29, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ86;Q3TZW1;Q3UVK5;Q3UYZ7;Q80ZK7;Q8C4A1;Q9JK31", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0016887 ATP hydrolysis activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q7TT18-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRK9-1", "uniprot_id": [ { "id": "MA2A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRK9", "type": "external" } ], "mass": 130649.0, "length": 1152, "protein_name": "Alpha-mannosidase 2x", "gene_name": "Man2a2", "organism": "Mouse", "refseq_name": "alpha-mannosidase 2x", "refseq_ac": [ { "id": "NP_766491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766491", "type": "external" } ], "gene_names_uniprotkb": "Man2a2; Mana2x", "gene_names_refseq": "1700052O22Rik; 4931438M07Rik; MX; Man IIx; Man2a2", "protein_names_uniprotkb": "Alpha-mannosidase 2x; 3.2.1.114; Alpha-mannosidase IIx; Man IIx; Mannosidase alpha class 2A member 2; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "protein_names_refseq": "alpha-mannosidase 2x; alpha-mannosidase IIx; mannosidase, alpha, class 2A, member 2; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:140481); (R-MMU-975578)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16754854;17113875;20805325;21750661;26495903;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity)., [UniProtKB]; Data show that either alpha-Mannosidase II or IIX can biochemically compensate for the deficiency of the other in vivo, and either of two is required for late embryonic and early postnatal development., [RefSeq, PubMed]; MX was produced by transfecting mammalian cells with expression vectors and the substrate specificity of MX was determined., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 56, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVK1", "ec_number_list": [ { "id": "3.2.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BRK9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AGH6-1", "uniprot_id": [ { "id": "MED12_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AGH6", "type": "external" } ], "mass": 244561.0, "length": 2190, "protein_name": "Mediator of RNA polymerase II transcription subunit 12", "gene_name": "Med12", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 12", "refseq_ac": [ { "id": "NP_067496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067496", "type": "external" } ], "gene_names_uniprotkb": "Med12; Kiaa0192; Mopa; Tnrc11; Trap230", "gene_names_refseq": "230kDa; Med12; Mopa; OPA-1; Tnrc11; Trap230", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 12; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein", "protein_names_refseq": "OPA-containing protein 1; mediator of RNA polymerase II transcription subunit 12; mediator of RNA polymerase II transcription, subunit 12 homolog; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein); trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); trinucleotide repeat-containing gene 11 protein", "tax_id": 10090, "disease": "syndromic X-linked intellectual disorder Lujan-Fryns-type (Disease Ontology:DOID:0080985); major depressive disorder (Disease Ontology:DOID:1470); FG syndrome (Disease Ontology:DOID:14711); leiomyosarcoma (Disease Ontology:DOID:1967); phobic disorder (Disease Ontology:DOID:591); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:59024)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;23806337;24129315;31219806;34428180;35018809;36971000;9702738", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity)., [UniProtKB]; MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots., [RefSeq, PubMed]; The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AGH7;O88542;Q571H3;Q6PGB4;Q6PGD8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0061630 ubiquitin protein ligase activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:1990508 CKM complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0021510 spinal cord development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2AGH6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04370-1", "uniprot_id": [ { "id": "MBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P04370", "type": "external" } ], "mass": 27168.0, "length": 250, "protein_name": "Myelin basic protein", "gene_name": "Mbp", "organism": "Mouse", "refseq_name": "Golli-Mbp isoform 2", "refseq_ac": [ { "id": "NP_001020416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020416", "type": "external" } ], "gene_names_uniprotkb": "Mbp; Shi", "gene_names_refseq": "Hmbpr; Mbp; golli-mbp; jve; mld; shi", "protein_names_uniprotkb": "Myelin basic protein; MBP; Myelin A1 protein", "protein_names_refseq": "Golli-Mbp isoform 2; myelin A1 protein; myelin deficient; shiverer", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); periventricular leukomalacia (Disease Ontology:DOID:13088); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); demyelinating disease (Disease Ontology:DOID:3213); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:17196)", "pathway_count": 1, "publication_count": 45, "publication_id_list": "10.1101/2023.09.13.557529;10190894;10209044;10229114;10716880;10861037;11040072;11145205;11593032;11812995;1279125;15648052;16452087;1692584;1705957;18034455;18375101;19144319;21183079;21750661;22058327;22645316;2410136;24129315;2416470;2425357;2433693;2452084;2470651;32848054;33300544;33374217;34428180;34678516;40021952;40885482;6198644;7511656;7524642;7543143;7680345;7681106;8666934;8784268;9736652", "class_list": "", "function": "The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function., [UniProtKB, PubMed]; The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 10, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q01585;Q03139;Q03176;Q61836;Q61837;Q99KE4;Q9QWP1", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0002020 protease binding;GO:0005516 calmodulin binding;GO:0017124 SH3 domain binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0043025 neuronal cell body", "go_biological_process": "GO:0000165 MAPK cascade;GO:0032755 positive regulation of interleukin-6 production;GO:0042552 myelination;GO:0061024 membrane organization;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "P04370-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61750-1", "uniprot_id": [ { "id": "ARF4_MOUSE", "url": "https://www.uniprot.org/uniprot/P61750", "type": "external" } ], "mass": 20397.0, "length": 180, "protein_name": "ADP-ribosylation factor 4", "gene_name": "Arf4", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor 4", "refseq_ac": [ { "id": "NP_031505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031505", "type": "external" } ], "gene_names_uniprotkb": "Arf4", "gene_names_refseq": "Arf4", "protein_names_uniprotkb": "ADP-ribosylation factor 4", "protein_names_refseq": "ADP-ribosylation factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:11843); (R-MMU-5620916); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "21750661;31201232;33300544;37280306;37453647;37848288;38816950;39627609;8947846", "class_list": "", "function": "ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development. Publication Status: Online-Only, [RefSeq, PubMed]; ARF4(+/-)/ARF5(-/-) mice exhibited essential tremor (ET)-like behaviors and abnormal brain acitivity when moving. The decreased expression of the class II ARF proteins in ARF4(+/-)/ARF5(-/-) mice leads to a haploinsufficiency of ARF4 in the absence of ARF5 and impairs the localization of Nav1.6 to the AIS and hence reduces the membrane excitability in PCs, resulting in the ET-like movement disorder., [RefSeq, PubMed]; Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4., [RefSeq, PubMed]; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)., [UniProtKB, UniProtKB]; Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36403;Q3TGC2;Q9CXX3", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005154 epidermal growth factor receptor binding;GO:1990583 phospholipase D activator activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007612 learning;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61750-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXJ4-1", "uniprot_id": [ { "id": "MITOS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXJ4", "type": "external" } ], "mass": 78000.0, "length": 717, "protein_name": "Mitochondrial potassium channel ATP-binding subunit", "gene_name": "Abcb8", "organism": "Mouse", "refseq_name": "mitochondrial potassium channel ATP-binding subunit precursor", "refseq_ac": [ { "id": "NP_083296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083296", "type": "external" } ], "gene_names_uniprotkb": "Abcb8; Mitosur", "gene_names_refseq": "4833412N02Rik; Abcb8; MITOSUR", "protein_names_uniprotkb": "Mitochondrial potassium channel ATP-binding subunit; ABCB8; ATP-binding cassette sub-family B member 8, mitochondrial; MITOSUR; Mitochondrial sulfonylurea-receptor", "protein_names_refseq": "ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 8; mitochondrial potassium channel ATP-binding subunit precursor; mitochondrial potassium channel ATP-binding subunit; mitochondrial sulfonylurea-receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74610); (R-MMU-1369007)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;22375032;25428506;30084848;31219806;33835027;34418053;34428180;37507081", "class_list": "", "function": "ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (By similarity). Plays a role in mitochondrial iron transport (PubMed:22375032). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (PubMed:22375032)., [UniProtKB, UniProtKB, PubMed]; Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C695;Q8C7W4", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006884 cell volume homeostasis;GO:0071805 potassium ion transmembrane transport;GO:0140141 mitochondrial potassium ion transmembrane transport;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CXJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVS6-1", "uniprot_id": [ { "id": "PRKN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVS6", "type": "external" } ], "mass": 51618.0, "length": 464, "protein_name": "E3 ubiquitin-protein ligase parkin", "gene_name": "Prkn", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase parkin isoform 2", "refseq_ac": [ { "id": "NP_001304655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304655", "type": "external" } ], "gene_names_uniprotkb": "Prkn; Park2", "gene_names_refseq": "Park2; Prkn", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase parkin; 2.3.2.31; Parkin RBR E3 ubiquitin-protein ligase", "protein_names_refseq": "E3 ubiquitin-protein ligase parkin isoform 2; E3 ubiquitin-protein ligase parkin; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkin protein", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); cardiomyopathy (Disease Ontology:DOID:0050700); Parkinson's disease 2 (Disease Ontology:DOID:0060368); Parkinson's disease 6 (Disease Ontology:DOID:0060369); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); cervical cancer (Disease Ontology:DOID:4362); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:50873); (R-MMU-5205685); (R-MMU-5675482); (R-MMU-5689877); (R-MMU-9646399); (R-MMU-983168)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10818204;11122330;11675120;12652124;15105460;19801972;21183079;21750661;21753002;22082830;24192653;24898855;25474007;29311685;29899409;32047033;35145192", "class_list": "", "function": "Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (By similarity). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:25474007, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (By similarity). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (By similarity). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (By similarity). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:22082830, PubMed:24898855, PubMed:25474007, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:22082830, PubMed:24898855, PubMed:32047033). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:25474007). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:21753002). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (By similarity). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:24192653). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (By similarity). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (By similarity). Limits the production of reactive oxygen species (ROS) (By similarity). Regulates cyclin-E during neuronal apoptosis (By similarity). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (By similarity). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KHJ9;Q9ES22;Q9ES23", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0097708 intracellular vesicle;GO:0099073 mitochondrion-derived vesicle;GO:0000139 Golgi membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903861 positive regulation of dendrite extension;GO:0010636 positive regulation of mitochondrial fusion;GO:2001171 positive regulation of ATP biosynthetic process;GO:0001964 startle response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WVS6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LJ2-1", "uniprot_id": [ { "id": "ABTB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LJ2", "type": "external" } ], "mass": 54058.0, "length": 478, "protein_name": "Ankyrin repeat and BTB/POZ domain-containing protein 1", "gene_name": "Abtb1", "organism": "Mouse", "refseq_name": "ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_084527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084527", "type": "external" } ], "gene_names_uniprotkb": "Abtb1; Bpoz", "gene_names_refseq": "Abtb1; BPOZ; EF1ABP", "protein_names_uniprotkb": "Ankyrin repeat and BTB/POZ domain-containing protein 1", "protein_names_refseq": "ankyrin repeat and BTB (POZ) domain containing 1; ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 1; ankyrin repeat and BTB/POZ domain-containing protein 1; mFLJ00331 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:80283)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11494141;21750661;26916519;34428180;36936774", "class_list": "", "function": "BPOZ-2 is a negative regulator of the NLPR3 inflammasome contributing to SARS-CoV-2-induced hyperinflammation. Publication Status: Online-Only, [RefSeq, PubMed]; BPOZ-2 was involved in a protein-protein association with PINK1 and therefore could stimulate PINK1-dependent autophagic clearance of alpha-synuclein. Publication Status: Online-Only, [RefSeq, PubMed]; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2K7;Q91XU4", "ec_number_list": [], "go_molecular_function": "GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99LJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88746-1", "uniprot_id": [ { "id": "TOM1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88746", "type": "external" } ], "mass": 54325.0, "length": 492, "protein_name": "Target of Myb1 membrane trafficking protein", "gene_name": "Tom1", "organism": "Mouse", "refseq_name": "target of Myb1 membrane trafficking protein isoform 1", "refseq_ac": [ { "id": "NP_035752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035752", "type": "external" } ], "gene_names_uniprotkb": "Tom1", "gene_names_refseq": "Tom1", "protein_names_uniprotkb": "Target of Myb1 membrane trafficking protein; Target of Myb protein 1", "protein_names_refseq": "target of Myb protein 1; target of Myb1 membrane trafficking protein isoform 1; target of Myb1 membrane trafficking protein; target of myb1 homolog", "tax_id": 10090, "disease": "immunodeficiency 85 (Disease Ontology:DOID:0061055)", "pathway": " (mmu:21968); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10329004;14563850;16412388;17242355;18250455;21183079;21750661;22645316;25588840;26495903;30185465;32782141;32848054;34428180;35822049;36288343;37828378;40885482", "class_list": "", "function": "A Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin, [RefSeq, PubMed]; Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (By similarity). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (By similarity). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (By similarity). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). Binds to polyubiquitinated proteins via its GAT domain (By similarity). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (By similarity). Mediates clathrin recruitment to early endosomes by ZFYVE16 (By similarity). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (By similarity). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (By similarity)., [UniProtKB, UniProtKB, PubMed]; Study shows that TOM1 regulates neuronal accumulation of amyloid-beta oligomers by FcgammaRIIb2 variant in Alzheimer's Disease (AD). Study provides a molecular mechanism responsible for neuronal uptake of pathogenic Abeta found in AD., [RefSeq, PubMed]; These results indicate that, in conjunction with Tollip, Tom1 family proteins play an important role in recruiting clathrin onto endosomes and suggest that they modulate endosomal functions., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3V4C6;Q9D120", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0030276 clathrin binding;GO:0043130 ubiquitin binding;GO:0070853 myosin VI binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0016197 endosomal transport;GO:1901098 positive regulation of autophagosome maturation;GO:1904978 regulation of endosome organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O88746-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C052-1", "uniprot_id": [ { "id": "MAP1S_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C052", "type": "external" } ], "mass": 102939.0, "length": 973, "protein_name": "Microtubule-associated protein 1S", "gene_name": "Map1s", "organism": "Mouse", "refseq_name": "microtubule-associated protein 1S", "refseq_ac": [ { "id": "NP_766601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766601", "type": "external" } ], "gene_names_uniprotkb": "Map1s; Bpy2ip1; Map8; Mtap1s", "gene_names_refseq": "6430517J16Rik; Bpy2ip1; Map1s; Map8; Mtap1s; VCY2IP1", "protein_names_uniprotkb": "Microtubule-associated protein 1S; BPY2-interacting protein 1; MAP-1S; Microtubule-associated protein 8", "protein_names_refseq": "BPY2 interacting protein 1; MAP-1S; microtubule-associated protein 1S; microtubule-associated protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:270058)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "15528209;16297881;16565160;21183079;21262964;21750661;22645316;25153642;26565030;26750654;27236336;28135057;28528544;30266824;31219806;34887587;36892418", "class_list": "", "function": "Axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein., [RefSeq, PubMed]; Clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance., [RefSeq, PubMed]; Data (including data from studies in knockout mice) suggest that Map1s interacts directly with MyD88 (myeloid differentiation primary response gene 88), a key adaptor of Toll-like receptors, as phagocytosis of bacteria is initiated in macrophages., [RefSeq, PubMed]; Depletion of MAP1S in mice leads to an accumulation of fibrosis-related proteins and the development of renal fibrosis in aged mice., [RefSeq, PubMed]; MAP1S-mediated autophagy plays an important role in maintaining mouse lifespan especially in the presence of extra amount of fibronectin., [RefSeq, PubMed]; MAP8 is a novel microtubule associated protein containing two microtubule binding domains., [RefSeq, PubMed]; Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles., [UniProtKB, PubMed]; Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QKR8;Q3TSD6;Q7TMW8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8C052-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5G3-1", "uniprot_id": [ { "id": "MBTD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5G3", "type": "external" } ], "mass": 70669.0, "length": 631, "protein_name": "MBT domain-containing protein 1", "gene_name": "Mbtd1", "organism": "Mouse", "refseq_name": "MBT domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001333454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333454", "type": "external" } ], "gene_names_uniprotkb": "Mbtd1", "gene_names_refseq": "Mbtd1; hemp", "protein_names_uniprotkb": "MBT domain-containing protein 1", "protein_names_refseq": "MBT domain-containing protein 1 isoform 2; MBT domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:103537)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23806337;31219806;34428180;37523546", "class_list": "", "function": "Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR)., [UniProtKB, UniProtKB]; MBTD1 preserves adult hematopoietic stem cell pool size and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3F0;Q8VE12", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0062060 NuA4 histone acetyltransferase complex binding;GO:0140005 histone H4K20me2 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0035861 site of double-strand break;GO:0000786 nucleosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P5G3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CA95-1", "uniprot_id": [ { "id": "PDE10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CA95", "type": "external" } ], "mass": 89408.0, "length": 790, "protein_name": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A", "gene_name": "Pde10a", "organism": "Mouse", "refseq_name": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1", "refseq_ac": [ { "id": "NP_001277636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277636", "type": "external" } ], "gene_names_uniprotkb": "Pde10a", "gene_names_refseq": "Pde10a", "protein_names_uniprotkb": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; 3.1.4.17", "protein_names_refseq": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase", "tax_id": 10090, "disease": "striatal degeneration 2 (Disease Ontology:DOID:0060998); traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (mmu:23984); (R-MMU-418457); (R-MMU-418555)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10359840;14751289;20485683;21750661;27058446;33300544;34550322;36075453", "class_list": "", "function": "Phosphodiesterase 10A deactivation induces long-term neurological recovery, Peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice., [RefSeq, PubMed]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10359840). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10359840). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:10359840, PubMed:14751289, PubMed:27058446)., [UniProtKB, PubMed, PubMed, PubMed]; Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling. Erratum:[Cardiovasc Res. 2023 May 2;119(3):879. doi: 10.1093/cvr/cvac011. PMID: 35137003], [RefSeq, PubMed]; Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLU6;Q3TRG6;Q69C21;Q9WVI1", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0046069 cGMP catabolic process;GO:0010754 negative regulation of cGMP-mediated signaling;GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CA95-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70137-1", "uniprot_id": [ { "id": "ALX3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70137", "type": "external" } ], "mass": 36851.0, "length": 343, "protein_name": "Homeobox protein aristaless-like 3", "gene_name": "Alx3", "organism": "Mouse", "refseq_name": "homeobox protein aristaless-like 3", "refseq_ac": [ { "id": "NP_031467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031467", "type": "external" } ], "gene_names_uniprotkb": "Alx3", "gene_names_refseq": "Alx3", "protein_names_uniprotkb": "Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3", "protein_names_refseq": "homeobox protein aristaless-like 3; proline-rich transcription factor Alx3", "tax_id": 10090, "disease": "frontonasal dysplasia 1 (Disease Ontology:DOID:0081045)", "pathway": " (mmu:11694)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20534379;21104068;21350340;21750661;25428506;9676189", "class_list": "", "function": "ALX3 could be considered as a candidate gene for the etiopathogenesis of diabetes or its complications during embryonic or fetal development is discussed, [RefSeq, PubMed]; ALX3 participates in the regulation of the expression of essential genes for the function of pancreatic islets, and its deficiency alters the regulation of glucose homeostasis in vivo., [RefSeq, PubMed]; Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects., [RefSeq, PubMed]; This gene belongs to Group 1 of aristaless-like genes, which are characterized by the presence of an aristaless domain and a conserved paired-like homeodomain. The encoded protein acts as a transcriptional regulator. The protein plays a role in the development of craniofacial and appendicular skeleton and may have a role in pancreatic function. [provided by RefSeq, Apr 2013]., [RefSeq]; Transcriptional regulator with a possible role in patterning of mesoderm during development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0035115 embryonic forelimb morphogenesis;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70137-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YE4-1", "uniprot_id": [ { "id": "LMTK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YE4", "type": "external" } ], "mass": 144607.0, "length": 1365, "protein_name": "Serine/threonine-protein kinase LMTK1", "gene_name": "Aatk", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase LMTK1 isoform 2", "refseq_ac": [ { "id": "NP_001185714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185714", "type": "external" } ], "gene_names_uniprotkb": "Aatk; Aatyk; Kiaa0641; Lmr1; Lmtk1", "gene_names_refseq": "AATYK; Aatk; aatyk1; mKIAA0641", "protein_names_uniprotkb": "Serine/threonine-protein kinase LMTK1; 2.7.11.1; AATYK; Apoptosis-associated tyrosine kinase; Brain apoptosis-associated tyrosine kinase; Lemur tyrosine kinase 1", "protein_names_refseq": "apoptosis-associated tyrosine kinase 1B; brain apoptosis-associated tyrosine kinase; lemur tyrosine kinase 1; serine/threonine-protein kinase LMTK1 isoform 2; serine/threonine-protein kinase LMTK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11302)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11314039;11314040;17651901;21183079;21750661;32044995;32552862;34428180;9444961", "class_list": "", "function": "Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation., [RefSeq, PubMed]; May be involved in neuronal differentiation., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6BLY8;O35211;Q3U2U5;Q3UHR8;Q66JN3;Q80YE3;Q8CB63;Q8CHE2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0030425 dendrite;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0038083 peptidyl-tyrosine autophosphorylation;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process;GO:0007420 brain development;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80YE4-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32MD9-1", "uniprot_id": [ { "id": "CDON_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32MD9", "type": "external" } ], "mass": 135422.0, "length": 1250, "protein_name": "Cell adhesion molecule-related/down-regulated by oncogenes", "gene_name": "Cdon", "organism": "Mouse", "refseq_name": "cell adhesion molecule-related/down-regulated by oncogenes precursor", "refseq_ac": [ { "id": "NP_067314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067314", "type": "external" } ], "gene_names_uniprotkb": "Cdon; Cdo", "gene_names_refseq": "CDO; Cd0; Cdon; Orcam", "protein_names_uniprotkb": "Cell adhesion molecule-related/down-regulated by oncogenes", "protein_names_refseq": "CAM-related/down-regulated by oncogenes; cell adhesion molecule-related/down-regulated by oncogenes precursor; cell adhesion molecule-related/down-regulated by oncogenes; immunoglobulin superfamily member CDO; oncogene-regulated cell adhesion molecule", "tax_id": 10090, "disease": "holoprosencephaly 11 (Disease Ontology:DOID:0110877)", "pathway": " (mmu:57810); (R-MMU-525793); (R-MMU-5632681); (R-MMU-5635838)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15520228;16647303;16647304;16648472;21664576;21750661;22872234;25428506;26495903;26740625;30084848;31219806;33038332;34428180;9786951", "class_list": "", "function": "Together with BOC, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (PubMed:16647303, PubMed:16647304, PubMed:21664576, PubMed:33038332). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (PubMed:33038332). ShhN is then directly transferred to patched receptor by GAS1 (PubMed:33038332). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (PubMed:9786951). Required for response to NTN3 and activation of NFATC3 (PubMed:15520228)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9310, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QKV9;O88971", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0010172 embryonic body morphogenesis;GO:0014816 skeletal muscle satellite cell differentiation;GO:0016202 regulation of striated muscle tissue development;GO:0051057 positive regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q32MD9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61091-1", "uniprot_id": [ { "id": "FZD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61091", "type": "external" } ], "mass": 73045.0, "length": 685, "protein_name": "Frizzled-8", "gene_name": "Fzd8", "organism": "Mouse", "refseq_name": "frizzled-8 precursor", "refseq_ac": [ { "id": "NP_032084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032084", "type": "external" } ], "gene_names_uniprotkb": "Fzd8", "gene_names_refseq": "Fz8; Fzd8", "protein_names_uniprotkb": "Frizzled-8; Fz-8; mFz8", "protein_names_refseq": "frizzled homolog 8; frizzled-8 precursor; frizzled-8; fz-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:14370); (R-MMU-4608870); (R-MMU-4641263)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10097073;10395542;11452312;11520064;15454084;16543246;22653731;30779550;31219806;34203471;34428180;8626800", "class_list": "", "function": "Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2RTK9", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:1990851 Wnt-Frizzled-LRP5/6 complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61091-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02111-1", "uniprot_id": [ { "id": "KPCT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02111", "type": "external" } ], "mass": 81573.0, "length": 707, "protein_name": "Protein kinase C theta type", "gene_name": "Prkcq", "organism": "Mouse", "refseq_name": "protein kinase C theta type isoform 1", "refseq_ac": [ { "id": "NP_032885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032885", "type": "external" } ], "gene_names_uniprotkb": "Prkcq; Pkcq", "gene_names_refseq": "A130035A12Rik; PKC-0; PKC-theta; PKCtheta; Pkcq; Prkcq", "protein_names_uniprotkb": "Protein kinase C theta type; 2.7.11.13; nPKC-theta", "protein_names_refseq": "PKC theta; nPKC-theta; protein kinase C theta type isoform 1; protein kinase C theta type", "tax_id": 10090, "disease": "hyperinsulinism (Disease Ontology:DOID:2018); prostate adenocarcinoma (Disease Ontology:DOID:2526); retinal detachment (Disease Ontology:DOID:5327)", "pathway": " (mmu:18761); (R-MMU-111465); (R-MMU-114508); (R-MMU-202424); (R-MMU-2871837); (R-MMU-373752); (R-MMU-9648002)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10746729;12782715;14725789;1508194;15263025;16493044;18086904;18263766;19047061;21183079;21364651;21750661;25381390;34428180;36456864", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Distinct subcellular localisation of intramyocellular lipids and reduced PKCepsilon/PKCtheta; activity preserve muscle insulin sensitivity in exercise-trained mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0042383 sarcolemma;GO:0034451 centriolar satellite", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0032740 positive regulation of interleukin-17 production;GO:2000570 positive regulation of T-helper 2 cell activation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q02111-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88572-1", "uniprot_id": [ { "id": "LRP6_MOUSE", "url": "https://www.uniprot.org/uniprot/O88572", "type": "external" } ], "mass": 180255.0, "length": 1613, "protein_name": "Low-density lipoprotein receptor-related protein 6", "gene_name": "Lrp6", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 6 precursor", "refseq_ac": [ { "id": "NP_032540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032540", "type": "external" } ], "gene_names_uniprotkb": "Lrp6", "gene_names_refseq": "C030016K15Rik; Cd; Gw; Lrp6; ska26; ska; skax26", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 6; LRP-6", "protein_names_refseq": "LRP-6; crooked; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6 precursor", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); neural tube defect (Disease Ontology:DOID:0080074); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:16974); (R-MMU-3772470); (R-MMU-4641262); (R-MMU-4641263)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "12573468;12581525;15142971;15469977;16543246;17376403;17698587;18505367;19857465;21750661;22491013;22615780;26015543;26495903;30258857;34428180;9704021", "class_list": "", "function": "Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0015026 coreceptor activity;GO:0034185 apolipoprotein binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060042 retina morphogenesis in camera-type eye;GO:0021861 forebrain radial glial cell differentiation;GO:0060535 trachea cartilage morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88572-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60787-1", "uniprot_id": [ { "id": "LCP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60787", "type": "external" } ], "mass": 60238.0, "length": 533, "protein_name": "Lymphocyte cytosolic protein 2", "gene_name": "Lcp2", "organism": "Mouse", "refseq_name": "lymphocyte cytosolic protein 2", "refseq_ac": [ { "id": "NP_034826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034826", "type": "external" } ], "gene_names_uniprotkb": "Lcp2", "gene_names_refseq": "Lcp2; SLP-76; SLP76; m1Khoe; twm", "protein_names_uniprotkb": "Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76", "protein_names_refseq": "SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; lymphocyte cytosolic protein 2", "tax_id": 10090, "disease": "immunodeficiency 81 (Disease Ontology:DOID:0061052)", "pathway": " (mmu:16822); (R-MMU-114604); (R-MMU-202433); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-2871809)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "10646608;10660534;10662792;16914752;17947660;18663126;19144319;21750661;24584089;26495903;27609517;28107427;28188290;30084848;30779550;31219806;31249969;33436632;34428180;36210013;7706237", "class_list": "", "function": "Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:10660534). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922M0", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0044853 plasma membrane raft;GO:0036398 TCR signalosome", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction;GO:0050852 T cell receptor signaling pathway;GO:0045576 mast cell activation;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q60787-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61033-1", "uniprot_id": [ { "id": "LAP2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61033", "type": "external" } ], "mass": 75168.0, "length": 693, "protein_name": "Lamina-associated polypeptide 2, isoforms alpha/zeta", "gene_name": "Tmpo", "organism": "Mouse", "refseq_name": "lamina-associated polypeptide 2 isoform alpha", "refseq_ac": [ { "id": "NP_035735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035735", "type": "external" } ], "gene_names_uniprotkb": "Tmpo; Lap2", "gene_names_refseq": "5630400D24Rik; LAP2; TP; Tmpo", "protein_names_uniprotkb": "Lamina-associated polypeptide 2, isoforms alpha/zeta; TP alpha/zeta; Thymopoietin isoforms alpha/zeta", "protein_names_refseq": "lamina-associated polypeptide 2 isoform alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:21917)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10393804;10413518;11591818;16452087;17242355;17562312;19131326;19144319;21183079;21540332;22645316;23806337;24129315;24463520;24788674;25153642;28528544;29187734;31219806;34428180;34887587;35820727;36288343;8743987", "class_list": "", "function": "May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1 (By similarity)., [UniProtKB]; May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RUB9;Q61028", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005694 chromosome;GO:0005637 nuclear inner membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q61033-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DVA0-1", "uniprot_id": [ { "id": "LEMD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DVA0", "type": "external" } ], "mass": 57507.0, "length": 511, "protein_name": "LEM domain-containing protein 2", "gene_name": "Lemd2", "organism": "Mouse", "refseq_name": "LEM domain-containing protein 2", "refseq_ac": [ { "id": "NP_666187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666187", "type": "external" } ], "gene_names_uniprotkb": "Lemd2; Lem2", "gene_names_refseq": "Lem2; Lemd2; NET25", "protein_names_uniprotkb": "LEM domain-containing protein 2; NET25; Nuclear envelope transmembrane protein 25", "protein_names_refseq": "LEM domain-containing protein 2; nuclear envelope constituent; nuclear envelope transmembrane protein 25", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cataract 46 juvenile-onset (Disease Ontology:DOID:0110243); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:224640)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;16339967;16452087;17062158;17242355;19720741;21183079;21750661;25790465;26495903;28056360;31219806;34428180;36377660;36656972;37067297", "class_list": "", "function": "Deregulation of cell signaling contributes to nuclear envelope-linked disorders and suggests that mutations in NET25 and MAN1 may cause muscle diseases., [RefSeq, PubMed]; Lem2 is essential for cardiac development by maintaining nuclear integrity., [RefSeq, PubMed]; Lemd2 plays an essential role in mouse embryonic development and that it is involved in regulating several signaling pathways. GeneRIF: Lemd2 is required for embryonic development in mouse and its loss is associated with highly elevated activity of AKT and MAP kinases. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanistic Insights of the LEMD2 p.L13R Mutation and Its Role in Cardiomyopathy., [RefSeq, PubMed]; Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (By similarity). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (PubMed:36377660). Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465). Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741). Essential for cardiac homeostasis and proper heart function (PubMed:36377660)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; We expressed a LEMD2 transgene alone or in combination with lamin C in these cells and observed no restoration of peripheral heterochromatin in either case. We conclude that in contrary to the B-tether, the A-tether has a more intricate composition and consists of multiple components that presumably vary, at differing degrees of redundancy, between cell types and differentiation stages, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4H8;Q8R0N2", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005819 spindle;GO:0031965 nuclear membrane;GO:0000785 chromatin;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0035914 skeletal muscle cell differentiation;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006998 nuclear envelope organization;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6DVA0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSS9-1", "uniprot_id": [ { "id": "LIPA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSS9", "type": "external" } ], "mass": 143234.0, "length": 1257, "protein_name": "Liprin-alpha-2", "gene_name": "Ppfia2", "organism": "Mouse", "refseq_name": "liprin-alpha-2 isoform 2", "refseq_ac": [ { "id": "NP_796347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796347", "type": "external" } ], "gene_names_uniprotkb": "Ppfia2", "gene_names_refseq": "5330438O12; B230207K17Rik; E130120L08Rik; Ppfia2; mKIAA4112", "protein_names_uniprotkb": "Liprin-alpha-2; PTPRF-interacting protein alpha-2; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2", "protein_names_refseq": "PTPRF interacting protein alpha 2; liprin-alpha-2 isoform 2; liprin-alpha-2; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:327814); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-388844)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;21750661;22645316;32848054;34678516;35822049;40885482", "class_list": "", "function": "Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1D2;Q8BN73", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0098919 structural constituent of postsynaptic density;GO:0099181 structural constituent of presynapse", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0050808 synapse organization;GO:0060998 regulation of dendritic spine development;GO:0061001 regulation of dendritic spine morphogenesis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099519 dense core granule cytoskeletal transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BSS9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXW9-1", "uniprot_id": [ { "id": "LAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXW9", "type": "external" } ], "mass": 57873.0, "length": 531, "protein_name": "Large neutral amino acids transporter small subunit 2", "gene_name": "Slc7a8", "organism": "Mouse", "refseq_name": "large neutral amino acids transporter small subunit 2", "refseq_ac": [ { "id": "NP_058668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058668", "type": "external" } ], "gene_names_uniprotkb": "Slc7a8; Lat2", "gene_names_refseq": "LAT2; Slc7a8", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8; mLAT2", "protein_names_refseq": "L-type amino acid transporter 2; large neutral amino acids transporter small subunit 2; mLAT2; solute carrier family 7 member 8; solute carrier family 8 (cationic amino acid transporter, y+ system), member 7", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:50934); (R-MMU-210991); (R-MMU-352230)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10574970;10610726;16085056;21183079;21726201;26601072;27802388;28108384;29355479;31231240", "class_list": "", "function": "Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10574970). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (PubMed:26601072, PubMed:28108384). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (PubMed:29355479). Mediates the uptake of leucine, 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0015820 L-leucine transport;GO:0035524 proline transmembrane transport;GO:1903801 L-leucine import across plasma membrane;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QXW9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08249-1", "uniprot_id": [ { "id": "MDHM_MOUSE", "url": "https://www.uniprot.org/uniprot/P08249", "type": "external" } ], "mass": 35611.0, "length": 338, "protein_name": "Malate dehydrogenase, mitochondrial", "gene_name": "Mdh2", "organism": "Mouse", "refseq_name": "malate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_032643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032643", "type": "external" } ], "gene_names_uniprotkb": "Mdh2; Mor1", "gene_names_refseq": "MDH; Mdh-2; Mdh2; Mor-1; Mor1", "protein_names_uniprotkb": "Malate dehydrogenase, mitochondrial; 1.1.1.37", "protein_names_refseq": "malate dehydrogenase, mitochondrial precursor; malate dehydrogenase, mitochondrial; mitochondrial malate dehydrogenase 2, NAD", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 51 (Disease Ontology:DOID:0080433); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:17448); (R-MMU-71403); (R-MMU-9837999); (R-MMU-9856872)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "16751257;21183079;21750661;22645316;23576753;23806337;26495903;30031227;3038184;33725478;3379635;33895326;34428180;35063410;35984892;36288343;36815302;37453647;37507081;39627609;39927985", "class_list": "", "function": "Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis., [RefSeq, PubMed]; Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor. Plays a central role in the tricarboxylic acid (TCA) cycle contributing to cellular respiration and energy production via the mitochondrial electron transport chain (By similarity). Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic flux between compartments (PubMed:35063410). In addition to its metabolic role, binds to RNA in cells, associating with cytosolic RNAs including tRNAs and mRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0QF44;Q8CF79;Q8R1P0", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030060 L-malate dehydrogenase (NAD+) activity;GO:0016615 malate dehydrogenase activity;GO:0046554 L-malate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0016020 membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006094 gluconeogenesis;GO:0009060 aerobic respiration;GO:0006108 malate metabolic process;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P08249-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LQ1-1", "uniprot_id": [ { "id": "MBIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LQ1", "type": "external" } ], "mass": 38333.0, "length": 341, "protein_name": "MAP3K12-binding inhibitory protein 1", "gene_name": "Mbip", "organism": "Mouse", "refseq_name": "MAP3K12-binding inhibitory protein 1", "refseq_ac": [ { "id": "NP_663417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663417", "type": "external" } ], "gene_names_uniprotkb": "Mbip", "gene_names_refseq": "4933408E06Rik; Mbip", "protein_names_uniprotkb": "MAP3K12-binding inhibitory protein 1; MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory protein", "protein_names_refseq": "MAP3K12-binding inhibitory protein 1; MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:217588); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;23806337;32963352", "class_list": "", "function": "Functions as part of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Together with MOCS2B, inhibits the activity of stress kinase EIF2AK2/PKR; this may lead to effects such as suppression of JNK activation and subsequent stress-responsive transcription, or suppression of eIF2a phosphorylation to favor translation., [UniProtKB, UniProtKB]; MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBM3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0072686 mitotic spindle", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99LQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54992-1", "uniprot_id": [ { "id": "MAPK5_MOUSE", "url": "https://www.uniprot.org/uniprot/O54992", "type": "external" } ], "mass": 54152.0, "length": 473, "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "Mapkapk5", "organism": "Mouse", "refseq_name": "MAP kinase-activated protein kinase 5", "refseq_ac": [ { "id": "NP_034895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034895", "type": "external" } ], "gene_names_uniprotkb": "Mapkapk5", "gene_names_refseq": "MK5; Mapkapk5; PRAK", "protein_names_uniprotkb": "MAP kinase-activated protein kinase 5; 2.7.11.1; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5", "protein_names_refseq": "MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:17165); (R-MMU-2559580); (R-MMU-5687128); (R-MMU-6804756)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "12242275;14560018;15538386;15577943;16973613;17254968;17947239;17997833;18248330;18268017;18720373;19473979;20640477;20734105;21336308;21575178;21750661;29237092;34360761;35468721;37126714;9480836", "class_list": "", "function": "Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress., [RefSeq, PubMed]; Data show that extracellular-regulated kinase 3 (ERK3) specifically interacts with the MAPK-activated protein kinase 5 (MK5 or PRAK) in vitro and in vivo., [RefSeq, PubMed]; Data suggest that the differences between the phenotypes of MK5- and MK2-deficient mice result from clearly different functional properties of both enzymes., [RefSeq, PubMed]; MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via regulating miR-429/ZEB1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5). Erratum:[EMBO J. 2005 Feb 23;24(4):873], [RefSeq, PubMed]; The Essential Role of PRAK in Preserving Cardiac Function and Insulin Resistance in High-Fat Diet-Induced Diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; The PRAK-NRF2 axis promotes the differentiation of Th17 cells by mediating the redox homeostasis and glycolysis., [RefSeq, PubMed]; Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ45;Q6QME4;Q6QME5;Q6QME6;Q6QME7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0032156 septin cytoskeleton;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0090400 stress-induced premature senescence;GO:0006417 regulation of translation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007265 Ras protein signal transduction;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O54992-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50481-1", "uniprot_id": [ { "id": "LHX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P50481", "type": "external" } ], "mass": 44010.0, "length": 400, "protein_name": "LIM/homeobox protein Lhx3", "gene_name": "Lhx3", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx3 isoform a", "refseq_ac": [ { "id": "NP_001034742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034742", "type": "external" } ], "gene_names_uniprotkb": "Lhx3; Lim-3; Lim3; Plim", "gene_names_refseq": "Lhx3; Lim3; P-LIM; mLIM3; mLim-3", "protein_names_uniprotkb": "LIM/homeobox protein Lhx3; Homeobox protein LIM-3; Homeobox protein P-LIM; LIM homeobox protein 3", "protein_names_refseq": "LIM homeo box protein 3; LIM/homeobox protein Lhx3 isoform a; LIM/homeobox protein Lhx3; homeobox protein LIM-3; homeobox protein P-LIM", "tax_id": 10090, "disease": "combined pituitary hormone deficiency 3 (Disease Ontology:DOID:0061021); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (mmu:16871)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10593900;12150931;18539116;18583962;25428506;7626792;7708713;7811383;9192866", "class_list": "", "function": "Transcription factor (PubMed:10593900, PubMed:12150931, PubMed:18539116). Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2 (PubMed:10593900, PubMed:18539116, PubMed:9192866). Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (PubMed:7708713). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (PubMed:12150931, PubMed:18539116)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALD9;Q61800;Q61801", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50481-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUV6-1", "uniprot_id": [ { "id": "LSM11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUV6", "type": "external" } ], "mass": 39907.0, "length": 361, "protein_name": "U7 snRNA-associated Sm-like protein LSm11", "gene_name": "Lsm11", "organism": "Mouse", "refseq_name": "U7 snRNA-associated Sm-like protein LSm11", "refseq_ac": [ { "id": "NP_082461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082461", "type": "external" } ], "gene_names_uniprotkb": "Lsm11", "gene_names_refseq": "2210404M20Rik; Lsm11", "protein_names_uniprotkb": "U7 snRNA-associated Sm-like protein LSm11", "protein_names_refseq": "U7 snRNA-associated Sm-like protein LSm11", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (mmu:72290); (R-MMU-111367); (R-MMU-73856); (R-MMU-77588)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12975319;15824063;16087681;16914750;19470752;24129315;25428506;31219806", "class_list": "", "function": "Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:12975319, PubMed:15824063). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:12975319, PubMed:15824063). Required for cell cycle progression from G1 to S phases (PubMed:16914750). Binds specifically to the Sm-binding site of U7 snRNA., [UniProtKB, PubMed, PubMed, PubMed]; Specifies the assembly of the U7 Sm core, also fulfills an important role in U7 snRNP-mediated histone mRNA processing., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071209 U7 snRNA binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:1902275 regulation of chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BUV6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCF0-1", "uniprot_id": [ { "id": "MAVS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCF0", "type": "external" } ], "mass": 53399.0, "length": 503, "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "Mavs", "organism": "Mouse", "refseq_name": "mitochondrial antiviral-signaling protein isoform 1", "refseq_ac": [ { "id": "NP_001193314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193314", "type": "external" } ], "gene_names_uniprotkb": "Mavs; Ips1; Visa", "gene_names_refseq": "D430028G21Rik; IPS-1; Mavs; Visa; cardif", "protein_names_uniprotkb": "Mitochondrial antiviral-signaling protein; CARD adapter inducing interferon beta; Cardif; IPS-1; Interferon beta promoter stimulator protein 1; MAVS; VISA; Virus-induced-signaling adapter", "protein_names_refseq": "CARD adapter inducing interferon beta; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein isoform 1; virus-induced signaling adapter", "tax_id": 10090, "disease": "", "pathway": " (mmu:228607); (R-MMU-168928); (R-MMU-936440); (R-MMU-9833482)", "pathway_count": 4, "publication_count": 40, "publication_id_list": "16125763;16153868;16177806;16785313;17242355;18849341;21183079;21750661;22645316;22872234;23087404;23582325;24037184;24129315;25153642;25428506;26495903;28135057;28528544;28934360;29187734;30059200;30084848;31219806;31599954;31616917;31685995;32848054;34203471;34428180;34678516;35820727;36210013;36288343;36852467;37507081;39927985;40021952;40885482;40997131", "class_list": "", "function": "Adapter required for innate immune defense against viruses (PubMed:24037184). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:24037184). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity). May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity). May protect cells from apoptosis (By similarity). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325)., [UniProtKB, UniProtKB, PubMed, PubMed]; Data suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral interferon signaling., [RefSeq, PubMed]; IPS-1 is the sole adapter in both retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5) signaling that mediates effective responses against a variety of RNA viruses., [RefSeq, PubMed]; The overexpression of mitochondrial antiviral signaling(MAVS)induces the expression of IFN-beta through activation of NF-kappaB and IRF 3, thus boosting antiviral immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 23, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 23, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 23, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0060760 positive regulation of response to cytokine stimulus;GO:0070585 protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "Q8VCF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922Q8-1", "uniprot_id": [ { "id": "LRC59_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922Q8", "type": "external" } ], "mass": 34877.0, "length": 307, "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "Lrrc59", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 59", "refseq_ac": [ { "id": "NP_598568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598568", "type": "external" } ], "gene_names_uniprotkb": "Lrrc59", "gene_names_refseq": "Lrrc59", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 59", "protein_names_refseq": "leucine-rich repeat-containing protein 59", "tax_id": 10090, "disease": "", "pathway": " (mmu:98238)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;22645316;23806337;24788674;28528544;31219806;33649389;34428180;37453647", "class_list": "", "function": "Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ35;Q3TLC7;Q3TWT9;Q3TX86", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0042645 mitochondrial nucleoid;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q922Q8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MV5-1", "uniprot_id": [ { "id": "M10L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MV5", "type": "external" } ], "mass": 132792.0, "length": 1187, "protein_name": "RNA helicase Mov10l1", "gene_name": "Mov10l1", "organism": "Mouse", "refseq_name": "RNA helicase Mov10l1", "refseq_ac": [ { "id": "NP_112550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112550", "type": "external" } ], "gene_names_uniprotkb": "Mov10l1; Champ", "gene_names_refseq": "CHAMP; Csm; Mov10l1", "protein_names_uniprotkb": "RNA helicase Mov10l1; 5.6.2.5; Cardiac helicase activated by MEF2 protein; Cardiac-specific RNA helicase; MOV10-like protein 1 homolog; Moloney leukemia virus 10-like protein 1 homolog; RNA 5'-3' helicase Mov10l1", "protein_names_refseq": "MOV10-like protein 1 homolog; Moloney leukemia virus 10-like 1 protein; RNA helicase Mov10l1; cardiac helicase activated by MEF2 protein; cardiac-specific RNA helicase; moloney leukemia virus 10-like protein 1 homolog; putative helicase Mov10l1", "tax_id": 10090, "disease": "spermatogenic failure 73 (Disease Ontology:DOID:0070572); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:83456)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11279525;11397016;11854500;12754203;20534472;20547853;21750661;23166510;25428506;25762440;33635934", "class_list": "", "function": "ATP-dependent 5'-3' RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins., [UniProtKB, UniProtKB, UniProtKB]; CHAMP acts as an inhibitor of cell proliferation and cardiomyocyte hypertrophy., [RefSeq, PubMed]; May act downstream of MEF2C during heart formation. Acts as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, suggesting that it may suppress these processes through the regulation of CDKN1A. Such results however require additional evidence., [UniProtKB, PubMed]; Nkx2.5 transactivates the Csm promoter, suggesting that Nkx2.5 is essential for embryonic Csm (cardiac-specific isoform of Mov10l1) expression, [RefSeq, PubMed]; Yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPA9;Q8C3W0;Q924C2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.1.1.386", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0034584 piRNA binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0071546 pi-body;GO:0043186 P granule;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99MV5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6I9-1", "uniprot_id": [ { "id": "LURA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6I9", "type": "external" } ], "mass": 25830.0, "length": 239, "protein_name": "Leucine rich adaptor protein 1", "gene_name": "Lurap1", "organism": "Mouse", "refseq_name": "leucine rich adaptor protein 1", "refseq_ac": [ { "id": "NP_080823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080823", "type": "external" } ], "gene_names_uniprotkb": "Lurap1; Lrap35a; Lrp35a", "gene_names_refseq": "1520402A15Rik; Lrp35a; Lurap1", "protein_names_uniprotkb": "Leucine rich adaptor protein 1; Leucine repeat adapter protein 35A", "protein_names_refseq": "NF-kappa-B activator C1orf190 homolog; leucine repeat adapter protein 35A; leucine rich adaptor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68075)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;28028174", "class_list": "", "function": "Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity)., [UniProtKB, UniProtKB]; Found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042641 actomyosin", "go_biological_process": "GO:0016477 cell migration;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D6I9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Z6-1", "uniprot_id": [ { "id": "MCAT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2Z6", "type": "external" } ], "mass": 33027.0, "length": 301, "protein_name": "Mitochondrial carnitine/acylcarnitine carrier protein", "gene_name": "Slc25a20", "organism": "Mouse", "refseq_name": "mitochondrial carnitine/acylcarnitine carrier protein", "refseq_ac": [ { "id": "NP_065266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065266", "type": "external" } ], "gene_names_uniprotkb": "Slc25a20; Cact; Cac", "gene_names_refseq": "1110007P09Rik; CAC; Cact; Slc25a20; mCAC", "protein_names_uniprotkb": "Mitochondrial carnitine/acylcarnitine carrier protein; CACT; CAC; Carnitine/acylcarnitine translocase; Solute carrier family 25 member 20; mCAC", "protein_names_refseq": "mitochondrial carnitine/acylcarnitine carrier protein", "tax_id": 10090, "disease": "carnitine-acylcarnitine translocase deficiency (Disease Ontology:DOID:0111585); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (mmu:57279); (R-MMU-200425)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19287344;19577614;22713466;23576753;23806337;34428180;37453647;37507081", "class_list": "", "function": "Data show that the upregulation of CACT by PPARalpha and PPARdelta may increase the import of acylcarnitine into the mitochondrial matrix during fasting., [RefSeq, PubMed]; Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism. Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation. Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange)., [UniProtKB, UniProtKB]; The 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha. This sequence binds ERRa both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1/ERR axis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U801", "ec_number_list": [], "go_molecular_function": "GO:0005476 carnitine:O-acyl-L-carnitine antiporter activity;GO:0015227 O-acyl-L-carnitine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006839 mitochondrial transport;GO:0006853 carnitine shuttle;GO:1902603 carnitine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z2Z6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33033-1", "uniprot_id": [ { "id": "MC3R_MOUSE", "url": "https://www.uniprot.org/uniprot/P33033", "type": "external" } ], "mass": 35806.0, "length": 323, "protein_name": "Melanocortin receptor 3", "gene_name": "Mc3r", "organism": "Mouse", "refseq_name": "melanocortin receptor 3", "refseq_ac": [ { "id": "NP_032587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032587", "type": "external" } ], "gene_names_uniprotkb": "Mc3r", "gene_names_refseq": "MC3-R; Mc3r", "protein_names_uniprotkb": "Melanocortin receptor 3; MC3-R", "protein_names_refseq": "melanocortin receptor 3", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17201); (R-MMU-375276); (R-MMU-418555)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19036988;37792535;8172596", "class_list": "", "function": "G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis (PubMed:8172596). Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (PubMed:19036988). Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency., [RefSeq, PubMed]; This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis and adaptation to food restriction. Disruption of this gene results in an increased ratio of weight gain to food intake, increased fat mass, and decreased lean mass, without having a large effect on insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017046 peptide hormone binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0060259 regulation of feeding behavior;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P33033-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMW7-1", "uniprot_id": [ { "id": "MAPK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMW7", "type": "external" } ], "mass": 43293.0, "length": 384, "protein_name": "MAP kinase-activated protein kinase 3", "gene_name": "Mapkapk3", "organism": "Mouse", "refseq_name": "MAP kinase-activated protein kinase 3 isoform 2", "refseq_ac": [ { "id": "NP_001303620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303620", "type": "external" } ], "gene_names_uniprotkb": "Mapkapk3", "gene_names_refseq": "3PK; MAPKAP-K3; MAPKAP3; MK-3; MK3; MapkKapk3; Mapkapk3", "protein_names_uniprotkb": "MAP kinase-activated protein kinase 3; 2.7.11.1; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3", "protein_names_refseq": "MAP kinase-activated protein kinase 3 isoform 2; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAPK-3", "tax_id": 10090, "disease": "patterned macular dystrophy 3 (Disease Ontology:DOID:0060865)", "pathway": " (mmu:102626); (R-MMU-171007); (R-MMU-2559580); (R-MMU-4420097); (R-MMU-450302)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "17030606;17906627;20570725;20724476;21750661;26744326;28011936;30084848;31334837;31527197;34428180;35984892;37828378", "class_list": "", "function": "IL-33-activated murine mast cells control the dichotomy between RORgammat(+) and Helios(+) Tregs via the MK2/3-mediated IL-6 production in vitro, [RefSeq, PubMed]; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression., [UniProtKB, PubMed, PubMed]; The MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP and the role of MK2 and MK3 in the regulation of TNF biosynthesis is not restricted to phosphorylation of TTP at S52/S178 but includes independent processes, which could involve other TTP phosphorylations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZU7;E9QNE1;Q3T9E6;Q8K0G3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0034097 response to cytokine;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3UMW7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIV2-1", "uniprot_id": [ { "id": "MBRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIV2", "type": "external" } ], "mass": 63561.0, "length": 574, "protein_name": "Membralin", "gene_name": "Tmem259", "organism": "Mouse", "refseq_name": "membralin isoform 2", "refseq_ac": [ { "id": "NP_001003949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949", "type": "external" } ], "gene_names_uniprotkb": "Tmem259; ORF61", "gene_names_refseq": "AC087114.7gm2; ORF61; R32184_3; Tmem259; mFLJ00277", "protein_names_uniprotkb": "Membralin; Transmembrane protein 259", "protein_names_refseq": "membralin isoform 2; membralin", "tax_id": 10090, "disease": "", "pathway": " (mmu:216157)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12638133;19349973;21750661;25428506;25977983;29133892;30899004;31112137;31599954;34428180", "class_list": "", "function": "Genomic organization and expression (membralin), [RefSeq, PubMed]; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress., [UniProtKB, PubMed]; Membralin plays a critical role in motor neuron survival, suggesting a novel mechanism for early-onset motor neuron disease. Publication Status: Online-Only, [RefSeq, PubMed]; Reduced membralin and EAAT2 levels correlated with disease progression in spinal cord from SOD1-mutant mouse models, and reductions in membralin/EAAT2 were observed in human ALS spinal cord. Importantly, overexpression of membralin in SOD1G93A astrocytes decreased TNFR1 levels and increased EAAT2 expression, and improved motor neuron survival. Publication Status: Online-Only, [RefSeq, PubMed]; The results identify membralin as an Endoplasmic-reticulum-associated degradation component and demonstrate a critical role for Endoplasmic-reticulum-associated degradation in Alzheimer's disease pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q68EE1;Q6KAN7;Q7TS84;Q8CIV1;Q99K29", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034976 response to endoplasmic reticulum stress;GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CIV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVQ1-1", "uniprot_id": [ { "id": "MAGI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVQ1", "type": "external" } ], "mass": 140919.0, "length": 1275, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2", "gene_name": "Magi2", "organism": "Mouse", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001164216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164216", "type": "external" } ], "gene_names_uniprotkb": "Magi2; Acvrinp1; Aip1; Arip1", "gene_names_refseq": "AIP-1; Acvri1; Acvrinp1; Acvrip1; Magi-2; Magi2; S-SCAM; mKIAA0705", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; AIP-1; Activin receptor-interacting protein 1; Acvrip1; Atrophin-1-interacting protein 1; MAGI-2; Membrane-associated guanylate kinase inverted 2", "protein_names_refseq": "activin receptor interacting protein 1; atrophin-1-interacting protein 1; membrane-associated guanylate kinase inverted 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2", "tax_id": 10090, "disease": "nephrotic syndrome type 15 (Disease Ontology:DOID:0080271); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:50791)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10681527;14750953;14988405;15340156;15466885;15509766;18034455;21183079;21750661;23751499;24608321;25428506;35260764;37950637;40885482", "class_list": "", "function": "Localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of CA3 pyramidal cells., [RefSeq, PubMed]; MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-beta-Smad3/nephrin pathway., [RefSeq, PubMed]; S-SCAM inhibits Axin-dependent synaptic function of GSK3beta in a sex-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (PubMed:10681527). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (PubMed:24608321)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH81;Q6GT88;Q8BYT1;Q8CA85", "ec_number_list": [], "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding;GO:0046332 SMAD binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9WVQ1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEE6-1", "uniprot_id": [ { "id": "PASK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEE6", "type": "external" } ], "mass": 151250.0, "length": 1383, "protein_name": "PAS domain-containing serine/threonine-protein kinase", "gene_name": "Pask", "organism": "Mouse", "refseq_name": "PAS domain-containing serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_543126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543126", "type": "external" } ], "gene_names_uniprotkb": "Pask; Kiaa0135", "gene_names_refseq": "Pask; mKIAA0135", "protein_names_uniprotkb": "PAS domain-containing serine/threonine-protein kinase; 2.7.11.1; PAS-kinase; PASKIN", "protein_names_refseq": "PAS domain-containing serine/threonine-protein kinase; PAS-kinase; paskin", "tax_id": 10090, "disease": "", "pathway": " (mmu:269224)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11688972;12972598;15148392;17192472;17878307;18509100;21181396;21183079;21750661;25428506;25428507;25605945;30084848;31974316;34428180;34444712;35011564;37052079", "class_list": "", "function": "Adipose-Specific PPARalpha Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue. Publication Status: Online-Only, [RefSeq, PubMed]; PAS kinase deficiency reduces aging effects in mice., [RefSeq, PubMed]; PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence. Publication Status: Online-Only, [RefSeq, PubMed]; Paskin gene expression is not induced by glucose in pancreatic beta-cells and glucose-stimulated insulin production is independent of PASKIN., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent. Publication Status: Online-Only, [RefSeq, PubMed]; Targeted disruption of the PAS domain serine/threonine kinase was studied., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QM58;Q91YD8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CEE6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPC1-1", "uniprot_id": [ { "id": "PARVA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPC1", "type": "external" } ], "mass": 42330.0, "length": 372, "protein_name": "Alpha-parvin", "gene_name": "Parva", "organism": "Mouse", "refseq_name": "alpha-parvin", "refseq_ac": [ { "id": "NP_065631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065631", "type": "external" } ], "gene_names_uniprotkb": "Parva; Actp; MNCb-0301", "gene_names_refseq": "2010012A22Rik; 5430400F08Rik; Actp; CH-ILKBP; Parva; Parvin", "protein_names_uniprotkb": "Alpha-parvin; Actopaxin", "protein_names_refseq": "actopaxin; alpha-parvin", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:57342); (R-MMU-446343); (R-MMU-446353); (R-MMU-446388)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11134073;11171322;11722847;16860736;19131326;19798050;21750661;31599954;37607905", "class_list": "", "function": "Alpha-parvin controls chondrocyte column formation and regulates long bone development. Publication Status: Online-Only, [RefSeq, PubMed]; Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization., [RefSeq, PubMed]; Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJ65", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0044877 protein-containing complex binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0007155 cell adhesion;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0034446 substrate adhesion-dependent cell spreading;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9EPC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08908-1", "uniprot_id": [ { "id": "P85B_MOUSE", "url": "https://www.uniprot.org/uniprot/O08908", "type": "external" } ], "mass": 81266.0, "length": 722, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "Pik3r2", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit beta isoform 1", "refseq_ac": [ { "id": "NP_032867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032867", "type": "external" } ], "gene_names_uniprotkb": "Pik3r2", "gene_names_refseq": "Pik3r2; p85beta", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta", "protein_names_refseq": "PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta isoform 1; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); ptdIns-3-kinase regulatory subunit p85-beta", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18709); (R-MMU-109704); (R-MMU-112399); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1266695); (R-MMU-1433557); (R-MMU-1660499); (R-MMU-186763); (R-MMU-198203); (R-MMU-201556); (R-MMU-202424); (R-MMU-2029485); (R-MMU-210993); (R-MMU-2424491); (R-MMU-2730905); (R-MMU-389357); (R-MMU-416476); (R-MMU-4420097); (R-MMU-512988); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-8980692); (R-MMU-9009391); (R-MMU-9013026); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013409); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-912526); (R-MMU-912631); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273); (R-MMU-9842663); (R-MMU-9927354)", "pathway_count": 40, "publication_count": 9, "publication_id_list": "15592455;16452087;17947660;18034455;20348926;21750661;21946561;34428180;9582025", "class_list": "", "function": "Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (By similarity). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U3K7", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0046982 protein heterodimerization activity;GO:0030971 receptor tyrosine kinase binding;GO:0019903 protein phosphatase binding;GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0010506 regulation of autophagy;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08908-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88643-1", "uniprot_id": [ { "id": "PAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88643", "type": "external" } ], "mass": 60737.0, "length": 545, "protein_name": "Serine/threonine-protein kinase PAK 1", "gene_name": "Pak1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pak1; Paka", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 1; 2.7.11.1; Alpha-PAK; CDC42/RAC effector kinase PAK-A; PAK-1; p21-activated kinase 1; p65-PAK", "protein_names_refseq": "", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (R-MMU-202433); (R-MMU-2029482); (R-MMU-2871796); (R-MMU-389359); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-399954); (R-MMU-445144); (R-MMU-445355); (R-MMU-5218920); (R-MMU-5621575); (R-MMU-5627123); (R-MMU-5687128); (R-MMU-8964616); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013420); (R-MMU-9013423); (R-MMU-9013424)", "pathway_count": 21, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10352232;10611223;12165471;12176334;15169762;15229651;15345747;15800193;18716323;21183079;21750661;22669945;22685302;22751929;23633677;25428506;26495903;26740625;35820727", "class_list": "", "function": "Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10611223, PubMed:12165471, PubMed:12176334, PubMed:15800193, PubMed:22669945, PubMed:23633677). Can directly phosphorylate BAD and protects cells against apoptosis (PubMed:10611223). Activated by interaction with CDC42 and RAC1 (By similarity). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (By similarity). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (By similarity). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:12176334). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (PubMed:12165471). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (By similarity). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (By similarity). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (By similarity). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (By similarity). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (By similarity). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193). Along with GIT1, positively regulates microtubule nucleation during interphase (By similarity). Phosphorylates FXR1, promoting its localization to stress granules and activity (By similarity). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9848, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0050770 regulation of axonogenesis;GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:1903608 protein localization to cytoplasmic stress granule;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O88643-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YV4-1", "uniprot_id": [ { "id": "PANK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YV4", "type": "external" } ], "mass": 91522.0, "length": 820, "protein_name": "4'-phosphopantetheine phosphatase", "gene_name": "Pank4", "organism": "Mouse", "refseq_name": "4'-phosphopantetheine phosphatase isoform 1", "refseq_ac": [ { "id": "NP_001292733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292733", "type": "external" } ], "gene_names_uniprotkb": "Pank4", "gene_names_refseq": "D030031I12Rik; Gm42363; Pank4", "protein_names_uniprotkb": "4'-phosphopantetheine phosphatase; 3.1.3.-; Inactive pantothenic acid kinase 4; mPanK4", "protein_names_refseq": "4'-phosphopantetheine phosphatase isoform 1; 4'-phosphopantetheine phosphatase; inactive pantothenic acid kinase 4; pantothenic acid kinase 4", "tax_id": 10090, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:269614); (R-MMU-199220)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11479594;16800626;21183079;21750661;30585370;31219806;34428180;37507081;39927985", "class_list": "", "function": "Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The association of a new entity of an autosomal dominant cataract with mutations in PANK4, which influences cell proliferation, apoptosis of lens epithelial cells, crystallin abnormalities, and fiber cell derangement, subsequently induces cataract., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AZN5;B1AZN6;Q7M751;Q8BQE9", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016791 phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process;GO:0015938 coenzyme A catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80YV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C015-1", "uniprot_id": [ { "id": "PAK5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C015", "type": "external" } ], "mass": 80948.0, "length": 719, "protein_name": "Serine/threonine-protein kinase PAK 5", "gene_name": "Pak5", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PAK 5", "refseq_ac": [ { "id": "NP_766446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766446", "type": "external" } ], "gene_names_uniprotkb": "Pak5; Pak7", "gene_names_refseq": "2900083L08Rik; PAK-5; PAK-7; Pak5; Pak7", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 5; 2.7.11.1; PAK-5; PAK-7; p21-activated kinase 5; p21-activated kinase 7", "protein_names_refseq": "p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:241656); (R-MMU-9013149); (R-MMU-9013407)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11756552;14517284;15615695;16452087;21183079;22872234;27802388;34678516;35820727", "class_list": "", "function": "PAK5 may provide a molecular rationale for late-stage complications in diabetes., [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQJ7;Q6RWS7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0007626 locomotory behavior;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8C015-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVD3-1", "uniprot_id": [ { "id": "PCD16_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVD3", "type": "external" } ], "mass": 346384.0, "length": 3291, "protein_name": "Protocadherin-16", "gene_name": "Dchs1", "organism": "Mouse", "refseq_name": "protocadherin-16 precursor", "refseq_ac": [ { "id": "NP_001156415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156415", "type": "external" } ], "gene_names_uniprotkb": "Dchs1", "gene_names_refseq": "3110041P15Rik; C130033F22Rik; CDH25; Dchs1; FIB1; Gm165; PCDH16", "protein_names_uniprotkb": "Protocadherin-16; Protein Dchs1; Protein dachsous homolog 1", "protein_names_refseq": "dachsous 1; protein Dchs1; protein dachsous homolog 1; protocadherin-16 precursor; protocadherin-16", "tax_id": 10090, "disease": "Van Maldergem syndrome 1 (Disease Ontology:DOID:0080585); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:233651)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16059920;19506035;21183079;21303848;21750661;24056717;26258302;30899004;34428180;36434174", "class_list": "", "function": "Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302)., [UniProtKB, PubMed, PubMed]; Data are compatible with conservation and sub-functionalization of dachsous 1, Fj, and Fat signaling in higher vertebrates, [RefSeq, PubMed]; Dchs1 and Fat4 function as a ligand-receptor pair during murine development, and novel requirements for Dchs1-Fat4 signaling in multiple organs are identified, [RefSeq, PubMed]; Neonatal lethality of mouse A/J-7[SM] consomic strain is caused by an insertion mutation in the Dchs1 gene., [RefSeq, PubMed]; Results highlight the importance of the Fat4-Dachsous1-Pals1 complex in organizing the apical membrane architecture of neural progenitor cells., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0045177 apical part of cell;GO:0016342 catenin complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0072006 nephron development;GO:0043931 ossification involved in bone maturation;GO:0072137 condensed mesenchymal cell proliferation;GO:0003192 mitral valve formation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "E9PVD3-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55134-1", "uniprot_id": [ { "id": "PCD12_MOUSE", "url": "https://www.uniprot.org/uniprot/O55134", "type": "external" } ], "mass": 128673.0, "length": 1180, "protein_name": "Protocadherin-12", "gene_name": "Pcdh12", "organism": "Mouse", "refseq_name": "protocadherin-12 precursor", "refseq_ac": [ { "id": "NP_059074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059074", "type": "external" } ], "gene_names_uniprotkb": "Pcdh12", "gene_names_refseq": "Pcdh12; Pcdh14; VE-cad-2", "protein_names_uniprotkb": "Protocadherin-12; VE-cad-2; VE-cadherin-2; Vascular cadherin-2; Vascular endothelial cadherin-2", "protein_names_refseq": "VE-cadherin-2; protocadherin 14; protocadherin-12 precursor; vascular cadherin-2; vascular endothelial cadherin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53601)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15541725;16269175;18477666;21183079;22205043;9651350", "class_list": "", "function": "Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (PubMed:9651350). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (By similarity). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (PubMed:9651350). Unable to bind to catenins, weakly associates with the cytoskeleton (PubMed:9651350)., [UniProtKB, UniProtKB, PubMed]; PCDH12 has a unique expression pattern and its deficiency does not lead to conspicuous abnormalities; it is the first specific marker for both glycogen-rich trophoblasts and mesangial cells., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G5E847", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0060711 labyrinthine layer development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55134-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60967-1", "uniprot_id": [ { "id": "PAPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60967", "type": "external" } ], "mass": 70794.0, "length": 624, "protein_name": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "gene_name": "Papss1", "organism": "Mouse", "refseq_name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform a", "refseq_ac": [ { "id": "NP_035993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035993", "type": "external" } ], "gene_names_uniprotkb": "Papss1; Asapk; Atpsk1; Papss", "gene_names_refseq": "Asapk; Papss1; SK1", "protein_names_uniprotkb": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; ATP-sulfurylase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; PAPS synthase 1; PAPSS 1; SAT; SK 1; SK1; Sulfate adenylate transferase; Sulfurylase kinase 1", "protein_names_refseq": "PAPS synthase 1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform a; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; sulfurylase kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23971); (R-MMU-174362)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;23806337;25153642;28135057;30084848;34428180;37828378;7493984", "class_list": "glycogene", "function": "Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:7493984). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U647", "ec_number_list": [ { "id": "2.7.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.25", "type": "external" }, { "id": "2.7.7.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016779 nucleotidyltransferase activity;GO:0004020 adenylylsulfate kinase activity;GO:0004781 sulfate adenylyltransferase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0009336 sulfate adenylyltransferase complex (ATP)", "go_biological_process": "GO:0000103 sulfate assimilation;GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60967-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61183-1", "uniprot_id": [ { "id": "PAPOA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61183", "type": "external" } ], "mass": 82309.0, "length": 739, "protein_name": "Poly(A) polymerase alpha", "gene_name": "Papola", "organism": "Mouse", "refseq_name": "poly(A) polymerase alpha isoform 1", "refseq_ac": [ { "id": "NP_035242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035242", "type": "external" } ], "gene_names_uniprotkb": "Papola; Pap; Plap", "gene_names_refseq": "PapIII; Papola; Pap; Plap", "protein_names_uniprotkb": "Poly(A) polymerase alpha; 2.7.7.19; PAP-alpha; Polynucleotide adenylyltransferase", "protein_names_refseq": "PAP-alpha; poly(A) polymerase alpha isoform 1; polynucleotide adenylyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:18789); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11716503;12471261;18084034;18281463;19224921;21183079;21750661;32782141;34418053;34428180;36852467;40885482;8628305", "class_list": "", "function": "Polymerase that creates the 3'-poly(A) tail of mRNA's., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q61208;Q61209;Q8K4X2", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0180011 cytosolic mRNA polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway;GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61183-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAS9-1", "uniprot_id": [ { "id": "PARP9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAS9", "type": "external" } ], "mass": 96659.0, "length": 866, "protein_name": "Protein mono-ADP-ribosyltransferase PARP9", "gene_name": "Parp9", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP9 isoform b", "refseq_ac": [ { "id": "NP_084529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084529", "type": "external" } ], "gene_names_uniprotkb": "Parp9; Bal", "gene_names_refseq": "ARTD9; Bagl; Bal; PARP-9; Parp9", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP9; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 9; ARTD9; B aggressive lymphoma protein homolog; PARP-9; Poly [ADP-ribose] polymerase 9", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 9; b aggressive lymphoma protein homolog; poly [ADP-ribose] polymerase 9; protein mono-ADP-ribosyltransferase PARP9 isoform b; protein mono-ADP-ribosyltransferase PARP9", "tax_id": 10090, "disease": "", "pathway": " (mmu:80285)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "18069692;19144319;21750661;25428506;25605945;26479788;26495903;27796300;28105679;30084848;31219806;31599954;34428180;37200107;37453647;40021952", "class_list": "", "function": "ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (By similarity). In addition, positively regulates DTXL3 protein levels (By similarity). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (By similarity). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (By similarity). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ) but the complex function is restrained by PARP9 activity (By similarity). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (PubMed:28105679). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Data indicate that PARP polymerase PARP9-E3 ligase DTX3L interacts with STAT1 transcription factor and enhances translocation of STAT1 to the nucleus., [RefSeq, PubMed]; Data show that Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut., [RefSeq, PubMed]; PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells Publication Status: Online-Only, [RefSeq, PubMed]; Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that Parp9-deficient mice are viable, fertile, and do not show any overt phenotype; Parp9 is dispensable for B-cell development, and that Parp9 is not essential for double-stranded DNA break repair, or that strong compensatory mechanisms exist, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRT6;Q99LF9", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CAS9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61021-1", "uniprot_id": [ { "id": "RAB5B_MOUSE", "url": "https://www.uniprot.org/uniprot/P61021", "type": "external" } ], "mass": 23707.0, "length": 215, "protein_name": "Ras-related protein Rab-5B", "gene_name": "Rab5b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-5B isoform a", "refseq_ac": [ { "id": "NP_803130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803130", "type": "external" } ], "gene_names_uniprotkb": "Rab5b", "gene_names_refseq": "C030027M18Rik; Rab5b", "protein_names_uniprotkb": "Ras-related protein Rab-5B; 3.6.5.2", "protein_names_refseq": "Ras-related protein Rab-5B; ras-related protein Rab-5B isoform a", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:19344); (R-MMU-6798695); (R-MMU-8856828); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "1555775;26399387;26740625;33300544;37828378;39927985;7789520", "class_list": "", "function": "Clear effect of subcutaneous zoledronic acid administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A and Rab14 in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can inhibit prenylation in myeloid cells in vivo outside the skeleton., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Required for EGF and transferrin endocytosis and trafficking through early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35239;P35277", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0007032 endosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P61021-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZA9-1", "uniprot_id": [ { "id": "TIGAR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZA9", "type": "external" } ], "mass": 29191.0, "length": 269, "protein_name": "Fructose-2,6-bisphosphatase TIGAR", "gene_name": "Tigar", "organism": "Mouse", "refseq_name": "fructose-2,6-bisphosphatase TIGAR", "refseq_ac": [ { "id": "NP_795977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795977", "type": "external" } ], "gene_names_uniprotkb": "Tigar", "gene_names_refseq": "9630033F20Rik; Tigar", "protein_names_uniprotkb": "Fructose-2,6-bisphosphatase TIGAR; 3.1.3.46; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase", "protein_names_refseq": "TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase; Trp53 induced glycolysis repulatory phosphatase; fructose-2,6-bisphosphatase TIGAR; probable fructose-2,6-bisphosphatase TIGAR", "tax_id": 10090, "disease": "", "pathway": " (mmu:319801); (R-MMU-5628897)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20935145;21750661;22044588;23726973;24872551;31599954;38686804;38773142", "class_list": "", "function": "Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:23726973). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:23726973). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (By similarity). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3 (PubMed:22044588). Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (PubMed:22044588). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (PubMed:24872551). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (By similarity). Involved in intestinal tumor progression (PubMed:23726973)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; P53 and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress., [RefSeq, PubMed]; P53/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis., [RefSeq, PubMed]; TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes. Erratum:[Autophagy. 2025 Oct;21(10):xii-xiv. doi: 10.1080/15548627.2024.2416687. PMID: 39440400], [RefSeq, PubMed]; TIGAR has roles in efficient intestinal regeneration and tumorigenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0043456 regulation of pentose-phosphate shunt;GO:0002931 response to ischemia;GO:0010332 response to gamma radiation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BZA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58681-1", "uniprot_id": [ { "id": "TLR7_MOUSE", "url": "https://www.uniprot.org/uniprot/P58681", "type": "external" } ], "mass": 121837.0, "length": 1050, "protein_name": "Toll-like receptor 7", "gene_name": "Tlr7", "organism": "Mouse", "refseq_name": "toll-like receptor 7 isoform a precursor", "refseq_ac": [ { "id": "NP_001277684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277684", "type": "external" } ], "gene_names_uniprotkb": "Tlr7", "gene_names_refseq": "Tlr7", "protein_names_uniprotkb": "Toll-like receptor 7", "protein_names_refseq": "Toll like receptor 7; toll-like receptor 7 isoform a precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); severe COVID-19 (Disease Ontology:DOID:0081013); X-Linked immunodeficiency 74 (Disease Ontology:DOID:0112063); anogenital venereal wart (Disease Ontology:DOID:11168); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:170743); (R-MMU-1679131); (R-MMU-168181); (R-MMU-5686938)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12875990;14976261;14976262;17452530;18250455;18305481;21402738;21750661;26095358;28011936;30084848;30779550;34428180;35477763;35984892", "class_list": "", "function": "Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (By similarity) (PubMed:14976261). In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state., [UniProtKB, UniProtKB, PubMed, PubMed]; Mediates species-specific recognition of GU-rich single-stranded RNA (ssRNA); data suggest that ssRNA represents a physiological ligand for TLR7, [RefSeq, PubMed]; Results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses, [RefSeq, PubMed]; Results suggest novel signaling pathway in murine macrophages involving synergy between toll-like receptors 2, 4, 7, and 9 and adenosine A(2A)receptors, that up-regulates VEGF and down-regulates TNFalpha expression, thus acting as an angiogenic switch., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q923I1", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0035197 siRNA binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0002718 regulation of cytokine production involved in immune response;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P58681-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUZ5-1", "uniprot_id": [ { "id": "TNNI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUZ5", "type": "external" } ], "mass": 21698.0, "length": 187, "protein_name": "Troponin I, slow skeletal muscle", "gene_name": "Tnni1", "organism": "Mouse", "refseq_name": "troponin I, slow skeletal muscle", "refseq_ac": [ { "id": "NP_001106173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106173", "type": "external" } ], "gene_names_uniprotkb": "Tnni1", "gene_names_refseq": "2700018B22Rik; Tnni1; ssTnI", "protein_names_uniprotkb": "Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform", "protein_names_refseq": "troponin I, slow skeletal muscle", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); heart disease (Disease Ontology:DOID:114); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (mmu:21952); (R-MMU-390522)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;33814345", "class_list": "", "function": "The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect., [RefSeq, PubMed]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0060048 cardiac muscle contraction;GO:0014883 transition between fast and slow fiber;GO:0055010 ventricular cardiac muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WUZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50752-1", "uniprot_id": [ { "id": "TNNT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P50752", "type": "external" } ], "mass": 35825.0, "length": 301, "protein_name": "Troponin T, cardiac muscle", "gene_name": "Tnnt2", "organism": "Mouse", "refseq_name": "troponin T, cardiac muscle isoform b", "refseq_ac": [ { "id": "NP_001123648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123648", "type": "external" } ], "gene_names_uniprotkb": "Tnnt2", "gene_names_refseq": "Tnnt2; Tnt; cTnT", "protein_names_uniprotkb": "Troponin T, cardiac muscle; Cardiac muscle troponin T; TnTc; cTnT", "protein_names_refseq": "cardiac TnT; cardiac muscle troponin T; tnTc; troponin T, cardiac muscle isoform b; troponin T, cardiac muscle", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy 2 (Disease Ontology:DOID:0110308); dilated cardiomyopathy 1D (Disease Ontology:DOID:0110426); familial restrictive cardiomyopathy 3 (Disease Ontology:DOID:0111427); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); nemaline myopathy (Disease Ontology:DOID:3191); restrictive cardiomyopathy (Disease Ontology:DOID:397); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:21956); (R-MMU-390522)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12832403;21750661;36288343", "class_list": "", "function": "Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64360;Q64377", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0005737 cytoplasm;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007507 heart development;GO:0051592 response to calcium ion;GO:0009617 response to bacterium;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50752-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U145-1", "uniprot_id": [ { "id": "TMM64_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U145", "type": "external" } ], "mass": 39815.0, "length": 381, "protein_name": "Transmembrane protein 64", "gene_name": "Tmem64", "organism": "Mouse", "refseq_name": "transmembrane protein 64", "refseq_ac": [ { "id": "NP_852066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852066", "type": "external" } ], "gene_names_uniprotkb": "Tmem64", "gene_names_refseq": "9630015D15Rik; Tmem64", "protein_names_uniprotkb": "Transmembrane protein 64", "protein_names_refseq": "CG11367 gene product; transmembrane protein 64", "tax_id": 10090, "disease": "", "pathway": " (mmu:100201)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23395171;25979161", "class_list": "", "function": "Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171). Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1 (PubMed:25979161)., [UniProtKB, PubMed, PubMed]; Tmem64 is a positive modulator of osteoclast differentiation via SERCA2-dependent Ca(2+) signaling., [RefSeq, PubMed]; Tmem64 plays an important role in the regulation of mesenchymal lineage allocation by modulating Wnt/beta-catenin signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCK1;Q3TE31;Q6YI45;Q8CBJ4;Q8K2Q6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045780 positive regulation of bone resorption;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U145-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3S2-1", "uniprot_id": [ { "id": "TNG6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3S2", "type": "external" } ], "mass": 118732.0, "length": 1079, "protein_name": "Transport and Golgi organization protein 6 homolog", "gene_name": "Tango6", "organism": "Mouse", "refseq_name": "transport and Golgi organization protein 6 homolog", "refseq_ac": [ { "id": "NP_766625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766625", "type": "external" } ], "gene_names_uniprotkb": "Tango6; Kiaa1746; Tmco7", "gene_names_refseq": "E330010G16; Tango6; Tmco7", "protein_names_uniprotkb": "Transport and Golgi organization protein 6 homolog; Transmembrane and coiled-coil domain-containing protein 7", "protein_names_refseq": "transmembrane and coiled-coil domain-containing protein 7; transmembrane and coiled-coil domains 7; transport and Golgi organization 6 homolog; transport and Golgi organization protein 6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:272538)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;25605945;38490996", "class_list": "", "function": "TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZB6;Q6NXV4;Q8C6M0;Q8C8G2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C3S2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923U0-1", "uniprot_id": [ { "id": "TM1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923U0", "type": "external" } ], "mass": 52695.0, "length": 474, "protein_name": "TOM1-like protein 1", "gene_name": "Tom1l1", "organism": "Mouse", "refseq_name": "TOM1-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001344472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001344472", "type": "external" } ], "gene_names_uniprotkb": "Tom1l1; Srcasm", "gene_names_refseq": "2310045L10Rik; Srcasm; Tom1l1", "protein_names_uniprotkb": "TOM1-like protein 1; Src-activating and signaling molecule protein; Target of Myb-like protein 1", "protein_names_refseq": "Jerry protein; Src activating and signaling molecule; TOM1-like protein 1 isoform 1; TOM1-like protein 1; src-activating and signaling molecule protein; target of Myb-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71943)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11711534;16479011;17046829;17785434;21183079;21750661;34418053;34428180;35820727;36210013", "class_list": "", "function": "Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions., [UniProtKB, PubMed]; Srcasm may act as a molecular 'rheostat' for activated Src family tyrosine kinases, [RefSeq, PubMed]; Tom1L1 defines a novel mechanism for regulation of Src family of protein-tyrosine kinases mitogenic signaling induced by growth factors., [RefSeq, PubMed]; Tom1L1-clathrin heavy chain (CHC) complex negatively regulates the level of SFK in caveolae needed for the induction of DNA synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0QZV4;Q5SRC7;Q5SRC9;Q99KE0;Q9D6Y5", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0030276 clathrin binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0015031 protein transport;GO:0032147 activation of protein kinase activity;GO:0045839 negative regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q923U0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPV0-1", "uniprot_id": [ { "id": "TM107_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPV0", "type": "external" } ], "mass": 15593.0, "length": 140, "protein_name": "Transmembrane protein 107", "gene_name": "Tmem107", "organism": "Mouse", "refseq_name": "transmembrane protein 107 isoform 1", "refseq_ac": [ { "id": "NP_080114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080114", "type": "external" } ], "gene_names_uniprotkb": "Tmem107", "gene_names_refseq": "1110004B13Rik; 2810049P21Rik; Tmem107", "protein_names_uniprotkb": "Transmembrane protein 107", "protein_names_refseq": "transmembrane protein 107 isoform 1", "tax_id": 10090, "disease": "Meckel syndrome 13 (Disease Ontology:DOID:0080253); orofaciodigital syndrome XVI (Disease Ontology:DOID:0080254)", "pathway": " (mmu:66910)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22698544;26518474;26595381;28954202;31887266", "class_list": "", "function": "Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types., [RefSeq, PubMed]; Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice., [RefSeq, PubMed]; Multiple roles in craniofacial development, [RefSeq, PubMed]; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474, PubMed:26595381)., [UniProtKB, PubMed, PubMed, PubMed]; TMEM107 Is a critical regulator of ciliary protein composition and is mutated in orofaciodigital syndrome mice., [RefSeq, PubMed]; TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RPS9;Q5SUQ6;Q9CZ71", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0003127 detection of nodal flow;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHE4-1", "uniprot_id": [ { "id": "TM108_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHE4", "type": "external" } ], "mass": 59642.0, "length": 574, "protein_name": "Transmembrane protein 108", "gene_name": "Tmem108", "organism": "Mouse", "refseq_name": "transmembrane protein 108 precursor", "refseq_ac": [ { "id": "NP_848753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848753", "type": "external" } ], "gene_names_uniprotkb": "Tmem108", "gene_names_refseq": "B130017P16Rik; Tmem108", "protein_names_uniprotkb": "Transmembrane protein 108; Retrolinkin", "protein_names_refseq": "retrolinkin; transmembrane protein 108 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:81907)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17287360;21750661;21849472;25428506;27605705;28096412;34203471;34690937", "class_list": "", "function": "Retrolinkin functions in the endocytic trafficking of BDNF-TrkB and mediates BDNF-triggered ERK signaling in CNS neurons, [RefSeq, PubMed]; The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons (PubMed:28096412). Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport (PubMed:17287360). In hippocampal neurons, required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes (PubMed:21849472, PubMed:27605705)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80WR9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0031175 neuron projection development;GO:0098815 modulation of excitatory postsynaptic potential;GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BHE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40142-1", "uniprot_id": [ { "id": "TKT_MOUSE", "url": "https://www.uniprot.org/uniprot/P40142", "type": "external" } ], "mass": 67630.0, "length": 623, "protein_name": "Transketolase", "gene_name": "Tkt", "organism": "Mouse", "refseq_name": "transketolase", "refseq_ac": [ { "id": "NP_033414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033414", "type": "external" } ], "gene_names_uniprotkb": "Tkt", "gene_names_refseq": "Tkt; p68", "protein_names_uniprotkb": "Transketolase; 2.2.1.1; P68; TK", "protein_names_refseq": "TK; transketolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:21881); (R-MMU-163754); (R-MMU-71336)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;15592455;18034455;20173027;21183079;21750661;23386199;23806337;26495903;26740625;33725478;34428180;34887587;35606596;36288343;37453647;37507081;39080260;8617775;9521875", "class_list": "", "function": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics., [RefSeq, PubMed]; This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7Y1;Q3UK62;Q545A1;Q9ESA0", "ec_number_list": [ { "id": "2.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0030976 thiamine pyrophosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0043209 myelin sheath", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0040008 regulation of growth;GO:0006098 pentose-phosphate shunt;GO:0046166 glyceraldehyde-3-phosphate biosynthetic process;GO:1901159 D-xylulose 5-phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P40142-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19123-1", "uniprot_id": [ { "id": "TNNC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P19123", "type": "external" } ], "mass": 18421.0, "length": 161, "protein_name": "Troponin C, slow skeletal and cardiac muscles", "gene_name": "Tnnc1", "organism": "Mouse", "refseq_name": "troponin C, slow skeletal and cardiac muscles", "refseq_ac": [ { "id": "NP_033419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033419", "type": "external" } ], "gene_names_uniprotkb": "Tnnc1; Tncc", "gene_names_refseq": "TnC; Tnnc1; cTnC; cTnI; tncc", "protein_names_uniprotkb": "Troponin C, slow skeletal and cardiac muscles; TN-C", "protein_names_refseq": "troponin C, slow skeletal and cardiac muscles", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 13 (Disease Ontology:DOID:0110319); dilated cardiomyopathy 1Z (Disease Ontology:DOID:0110434); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:21924); (R-MMU-390522)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;21750661;2753913;32931484", "class_list": "", "function": "Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. Publication Status: Online-Only, [RefSeq, PubMed]; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031014 troponin T binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0030017 sarcomere;GO:0043292 contractile muscle fiber;GO:0005861 troponin complex", "go_biological_process": "GO:0086003 cardiac muscle cell contraction;GO:0003009 skeletal muscle contraction;GO:0030049 muscle filament sliding;GO:0060048 cardiac muscle contraction;GO:0014883 transition between fast and slow fiber", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19123-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W04-1", "uniprot_id": [ { "id": "TMCC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W04", "type": "external" } ], "mass": 77054.0, "length": 706, "protein_name": "Transmembrane and coiled-coil domains protein 2", "gene_name": "Tmcc2", "organism": "Mouse", "refseq_name": "transmembrane and coiled-coil domains protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001298036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298036", "type": "external" } ], "gene_names_uniprotkb": "Tmcc2; Kiaa0481", "gene_names_refseq": "1110063G11Rik; Tmcc2", "protein_names_uniprotkb": "Transmembrane and coiled-coil domains protein 2", "protein_names_refseq": "transmembrane and coiled-coil domains protein 2 isoform 2; transmembrane and coiled-coil domains protein 2", "tax_id": 10090, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667)", "pathway": " (mmu:68875)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;22645316;24129315;30084848;35563652;36617157", "class_list": "", "function": "Ablation of Tmcc2 Gene Impairs Erythropoiesis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death., [RefSeq, PubMed]; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6A061", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0016020 membrane", "go_biological_process": "GO:0042982 amyloid precursor protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80W04-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFY9-1", "uniprot_id": [ { "id": "TNPO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFY9", "type": "external" } ], "mass": 102357.0, "length": 898, "protein_name": "Transportin-1", "gene_name": "Tnpo1", "organism": "Mouse", "refseq_name": "transportin-1 isoform 2", "refseq_ac": [ { "id": "NP_001041732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041732", "type": "external" } ], "gene_names_uniprotkb": "Tnpo1; Kpnb2", "gene_names_refseq": "D13Ertd688e; IPO2; Kpnb2; MIP1; MIP; TRN; Tnpo1", "protein_names_uniprotkb": "Transportin-1; Importin beta-2; Karyopherin beta-2", "protein_names_refseq": "importin beta-2; karyopherin (importin) beta 2; karyopherin beta-2; transportin-1 isoform 2", "tax_id": 10090, "disease": "intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (Disease Ontology:DOID:0081262)", "pathway": " (mmu:238799); (R-MMU-450513); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11493596;21750661;24912681;25378700;26136363;30084848;34428180;37828378;39627609", "class_list": "", "function": "Association with Tnpo1 is necessary for Oxtr nuclear localization. This is required for Oxt-induced osteoblast differentiation. osteoblast differentiation., [RefSeq, PubMed]; Co-immunoprecipitation and affinity-binding studies revealed that Rab23 exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 for its ciliary transport, [RefSeq, PubMed]; DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2., [RefSeq, PubMed]; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11493596). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In vitro, mediates nuclear import of SRP19 (By similarity). Mediates the import of histones H2A, H2B, H3 and H4 (PubMed:11493596). Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0S3;Q8K2E7", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BFY9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU11-1", "uniprot_id": [ { "id": "TOX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU11", "type": "external" } ], "mass": 65961.0, "length": 619, "protein_name": "TOX high mobility group box family member 4", "gene_name": "Tox4", "organism": "Mouse", "refseq_name": "TOX high mobility group box family member 4", "refseq_ac": [ { "id": "NP_075923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075923", "type": "external" } ], "gene_names_uniprotkb": "Tox4", "gene_names_refseq": "5730589K01Rik; A630040M18; LCP1; Tox4", "protein_names_uniprotkb": "TOX high mobility group box family member 4; Epidermal Langerhans cell protein LCP1", "protein_names_refseq": "TOX high mobility group box family member 4; epidermal Langerhans cell protein LCP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268741)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "17242355;19144319;21183079;24129315;31519808;32782141;32848054;34428180;34678516;34914893;35365735;36852467;37286708;38212319;40021952;40885482;40997131", "class_list": "", "function": "E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (PubMed:31519808). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (PubMed:34914893). This regulation is independent of the insulin receptor activation (PubMed:34914893). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:35365735). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:35365735). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGN7;Q80UI2;Q99PN9;Q9CS16", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BU11-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQG9-1", "uniprot_id": [ { "id": "TM100_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQG9", "type": "external" } ], "mass": 14504.0, "length": 134, "protein_name": "Transmembrane protein 100", "gene_name": "Tmem100", "organism": "Mouse", "refseq_name": "transmembrane protein 100", "refseq_ac": [ { "id": "NP_080709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080709", "type": "external" } ], "gene_names_uniprotkb": "Tmem100", "gene_names_refseq": "1810057C19Rik; Tmem100", "protein_names_uniprotkb": "Transmembrane protein 100", "protein_names_refseq": "transmembrane protein 100", "tax_id": 10090, "disease": "", "pathway": " (mmu:67888)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20848592;21183079;22783020;23485812;25640077;31112734", "class_list": "", "function": "Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10 (PubMed:22783020). Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons (PubMed:25640077). Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex (PubMed:25640077)., [UniProtKB, PubMed, PubMed]; Tmem100 was predominantly expressed in arterial endothelial cells of developing embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007219 Notch signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQG9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QMY9-1", "uniprot_id": [ { "id": "TO6BL_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QMY9", "type": "external" } ], "mass": 63797.0, "length": 579, "protein_name": "Type 2 DNA topoisomerase 6 subunit B-like", "gene_name": "Top6bl", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Top6bl; Gm960", "gene_names_refseq": "", "protein_names_uniprotkb": "Type 2 DNA topoisomerase 6 subunit B-like; TOP6B like initiator of meiotic double strand breaks; TOPOVIBL; Type 2 DNA topoisomerase VI subunit B-like", "protein_names_refseq": "", "tax_id": 10090, "disease": "gestational trophoblastic neoplasm (Disease Ontology:DOID:3590)", "pathway": " (mmu:381196)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;25428506;26917764;35820727;36396648;36732965;38966985;39972129;39972130", "class_list": "", "function": "Non-catalytic component of a topoisomerase 6 complex specifically required for double-strand breaks (DSB) formation that initiate meiotic recombination (PubMed:26917764, PubMed:36396648, PubMed:36732965, PubMed:38966985, PubMed:39972129, PubMed:39972130). Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917764, PubMed:39972129, PubMed:39972130). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed:26917764, PubMed:39972129, PubMed:39972130). Within the complex, TOP6BL may sense specific DNA architectures, such as bendable and underwound DNA for cleavage by SPO11 (PubMed:38966985)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY62", "ec_number_list": [], "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "go_cellular_component": "GO:0005694 chromosome", "go_biological_process": "GO:0042138 meiotic DNA double-strand break formation;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "J3QMY9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TBL6-1", "uniprot_id": [ { "id": "TP8L3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TBL6", "type": "external" } ], "mass": 23243.0, "length": 204, "protein_name": "Tumor necrosis factor alpha-induced protein 8-like protein 3", "gene_name": "Tnfaip8l3", "organism": "Mouse", "refseq_name": "tumor necrosis factor alpha-induced protein 8-like protein 3", "refseq_ac": [ { "id": "NP_001028707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028707", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip8l3", "gene_names_refseq": "9930029P06Rik; Gm517; Tnfaip8l3", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3", "protein_names_refseq": "TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3; tumor necrosis factor alpha-induced protein 8-like protein 3; tumor necrosis factor, alpha-induced protein 8-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:244882); (R-MMU-1483255)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25242044;25479791", "class_list": "", "function": "Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling., [UniProtKB, PubMed]; Tnfaip8l3 expression was almost identical in most organs from human and mice. Tnfaip8l3 is a cytoplasmic protein expressed preferentially in epithelial-derived cells with secretory functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0015914 phospholipid transport;GO:0042981 regulation of apoptotic process;GO:1902531 regulation of intracellular signal transduction;GO:1902633 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TBL6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4Q9-1", "uniprot_id": [ { "id": "TM154_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4Q9", "type": "external" } ], "mass": 19879.0, "length": 181, "protein_name": "Transmembrane protein 154", "gene_name": "Tmem154", "organism": "Mouse", "refseq_name": "transmembrane protein 154 precursor", "refseq_ac": [ { "id": "NP_796234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796234", "type": "external" } ], "gene_names_uniprotkb": "Tmem154", "gene_names_refseq": "9930117H01Rik; Tmem154", "protein_names_uniprotkb": "Transmembrane protein 154", "protein_names_refseq": "transmembrane protein 154 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:320782)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17947660;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB17;Q3TCN6;Q3TD45;Q8CB06", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C4Q9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERE8-1", "uniprot_id": [ { "id": "TLRN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERE8", "type": "external" } ], "mass": 37786.0, "length": 362, "protein_name": "Talin rod domain-containing protein 1", "gene_name": "Tlnrd1", "organism": "Mouse", "refseq_name": "talin rod domain-containing protein 1", "refseq_ac": [ { "id": "NP_109630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109630", "type": "external" } ], "gene_names_uniprotkb": "Tlnrd1; Mesdc1", "gene_names_refseq": "Mesdc1; Tlnrd1", "protein_names_uniprotkb": "Talin rod domain-containing protein 1; Mesoderm development candidate 1", "protein_names_refseq": "mesoderm development candidate 1; talin rod domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:80889)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11247670;17242355;20610383", "class_list": "", "function": "Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells., [UniProtKB, UniProtKB]; Study show that the MESDc1 protein, which is predicted to have a similar fold, is a novel actin-binding protein., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q542D0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8U2-1", "uniprot_id": [ { "id": "TM201_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8U2", "type": "external" } ], "mass": 72500.0, "length": 664, "protein_name": "Transmembrane protein 201", "gene_name": "Tmem201", "organism": "Mouse", "refseq_name": "transmembrane protein 201 isoform c", "refseq_ac": [ { "id": "NP_001271199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271199", "type": "external" } ], "gene_names_uniprotkb": "Tmem201; D4Ertd429e; Net5; Samp1", "gene_names_refseq": "D4Ertd429e; Net5; Samp1; Tmem201", "protein_names_uniprotkb": "Transmembrane protein 201; Spindle-associated membrane protein 1", "protein_names_refseq": "spindle-associated membrane protein 1; transmembrane protein 201 isoform c", "tax_id": 10090, "disease": "", "pathway": " (mmu:230917)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "22349700;23583482;25051721;28301579;28893537;33401680;34428180;35311970;35792174;37507081;40997131", "class_list": "", "function": "At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction., [RefSeq, PubMed]; Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Critical regulator of angiogenesis and endothelial cell (EC) migration. Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope. This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (By similarity). Involved in nuclear movement during fibroblast polarization and migration (PubMed:22349700). May recruit Ran GTPase to the nuclear periphery (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis Publication Status: Online-Only, [RefSeq, PubMed]; Findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration GeneRIF: Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C., [RefSeq, PubMed]; In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex, [RefSeq, PubMed]; May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina., [UniProtKB, UniProtKB]; Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow., [UniProtKB, PubMed]; These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice., [RefSeq, PubMed]; Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5F3;Q6GQS9;Q8BNY3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0001525 angiogenesis;GO:0010595 positive regulation of endothelial cell migration;GO:0006998 nuclear envelope organization;GO:0010761 fibroblast migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2A8U2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4Q9E8-1", "uniprot_id": [ { "id": "TTLL6_MOUSE", "url": "https://www.uniprot.org/uniprot/A4Q9E8", "type": "external" } ], "mass": 94507.0, "length": 822, "protein_name": "Tubulin polyglutamylase TTLL6", "gene_name": "Ttll6", "organism": "Mouse", "refseq_name": "tubulin polyglutamylase TTLL6", "refseq_ac": [ { "id": "NP_766387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387", "type": "external" } ], "gene_names_uniprotkb": "Ttll6", "gene_names_refseq": "4932418K24Rik; D11Moh43e; D11Moh44e; Ttll6; t8130b59", "protein_names_uniprotkb": "Tubulin polyglutamylase TTLL6; 6.3.2.-; Protein polyglutamylase TTLL6; Tubulin--tyrosine ligase-like protein 6", "protein_names_refseq": "polyglutamylase; protein polyglutamylase TTLL6; tubulin polyglutamylase TTLL6; tubulin--tyrosine ligase-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:237930); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17499049;17971504;20530212;21074048;22246503;23897886;26829768;31219806;32747782", "class_list": "", "function": "Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768, PubMed:32747782). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768, PubMed:32747782). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:32747782). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (PubMed:20530212). Mediates microtubule polyglutamylation in primary cilia axoneme which is important for ciliary structural formation and motility (PubMed:22246503). Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating (PubMed:23897886). Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response (PubMed:26829768)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Erratum:[Nat Struct Mol Biol. 2020 Sep;27(9):870. doi: 10.1038/s41594-020-0498-1. PMID: 32792670], [RefSeq, PubMed]; Ttll6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6M6;B2RQS4;Q3UL10;Q8BVQ1", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0070739 protein-glutamic acid ligase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:0051013 microtubule severing;GO:0018095 protein polyglutamylation;GO:0060296 regulation of cilium beat frequency involved in ciliary motility;GO:0001578 microtubule bundle formation;GO:0003353 positive regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A4Q9E8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R138-1", "uniprot_id": [ { "id": "TM119_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R138", "type": "external" } ], "mass": 29401.0, "length": 280, "protein_name": "Transmembrane protein 119", "gene_name": "Tmem119", "organism": "Mouse", "refseq_name": "transmembrane protein 119 precursor", "refseq_ac": [ { "id": "NP_666274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666274", "type": "external" } ], "gene_names_uniprotkb": "Tmem119", "gene_names_refseq": "Tmem119; obif", "protein_names_uniprotkb": "Transmembrane protein 119; OBIF; Osteoblast induction factor", "protein_names_refseq": "osteoblast induction factor; transmembrane protein 119 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:231633)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20025746;20485683;21239498;21750661;22416756;22579779;24362451;26207632", "class_list": "", "function": "Obif plays an essential role in bone formation through regulating osteoblastogenesis., [RefSeq, PubMed]; Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway., [RefSeq, PubMed]; Plays an important role in bone formation and normal bone mineralization (PubMed:20025746, PubMed:22416756, PubMed:26207632). Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746, PubMed:22416756, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study identifies a novel gene, obif (osteoblast induction factor), encoding a transmembrane protein that is predominantly expressed in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP14", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903012 positive regulation of bone development;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0030509 BMP signaling pathway;GO:0033690 positive regulation of osteoblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R138-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3S2-1", "uniprot_id": [ { "id": "TSN33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3S2", "type": "external" } ], "mass": 31550.0, "length": 283, "protein_name": "Tetraspanin-33", "gene_name": "Tspan33", "organism": "Mouse", "refseq_name": "tetraspanin-33 isoform 2", "refseq_ac": [ { "id": "NP_001288336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288336", "type": "external" } ], "gene_names_uniprotkb": "Tspan33; Pen", "gene_names_refseq": "1300010A20Rik; Pen; Tspan33", "protein_names_uniprotkb": "Tetraspanin-33; Penumbra; Proerythroblast new membrane; Tspan-33; mPen", "protein_names_refseq": "penumbra; proerythroblast new membrane; tetraspanin-33 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:232670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17158226;23035126;26668317;27574297;30463011", "class_list": "", "function": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (By similarity). Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors (PubMed:17158226). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011)., [UniProtKB, UniProtKB, PubMed, PubMed]; Penumbra has a positive function in erythropoiesis and its deletion or mutation may result in anemia., [RefSeq, PubMed]; The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target., [RefSeq, PubMed]; This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA03", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046931 pore complex assembly;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R3S2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1T2-1", "uniprot_id": [ { "id": "TSP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1T2", "type": "external" } ], "mass": 106366.0, "length": 963, "protein_name": "Thrombospondin-4", "gene_name": "Thbs4", "organism": "Mouse", "refseq_name": "thrombospondin-4 precursor", "refseq_ac": [ { "id": "NP_035712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035712", "type": "external" } ], "gene_names_uniprotkb": "Thbs4; Tsp4", "gene_names_refseq": "TSP4; Thbs4", "protein_names_uniprotkb": "Thrombospondin-4", "protein_names_refseq": "thrombospondin-4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:21828); (R-MMU-186797)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10501972;20884877;22034490;22362893;22682248;22745497;23615612;38876442;38926599", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress., [RefSeq, PubMed]; Thrombospondin-4 deletion does not exacerbate muscular dystrophy in beta-sarcoglycan-deficient and laminin alpha2 chain-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYS3;Q9WUE0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0005604 basement membrane", "go_biological_process": "GO:0071603 endothelial cell-cell adhesion;GO:0007399 nervous system development;GO:0048812 neuron projection morphogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z1T2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00899-1", "uniprot_id": [ { "id": "TYY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00899", "type": "external" } ], "mass": 44717.0, "length": 414, "protein_name": "Transcriptional repressor protein YY1", "gene_name": "Yy1", "organism": "Mouse", "refseq_name": "transcriptional repressor protein YY1", "refseq_ac": [ { "id": "NP_033563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033563", "type": "external" } ], "gene_names_uniprotkb": "Yy1; Ucrbp", "gene_names_refseq": "NF-E1; YY-1; Yy1", "protein_names_uniprotkb": "Transcriptional repressor protein YY1; Delta transcription factor; NF-E1; UCR-motif DNA-binding protein; YY-1; Yin and yang 1", "protein_names_refseq": "UCR-motif DNA-binding protein; UCRBP transcription factor; Yin Yang 1; delta transcription factor; transcriptional repressor protein YY1; yin and yang 1", "tax_id": 10090, "disease": "pleuropulmonary blastoma (Disease Ontology:DOID:4769); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:22632); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "1309593;15329343;18024232;18026119;1946404;19786570;21183079;21454521;31629407;34428180;38990722;39210046;39362773;39627609;40128797;8516301", "class_list": "", "function": "Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'-CGCCATTTT-3') of Moloney murine leukemia virus (MuLV). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Involved in spermatogenesis and may play a role in meiotic DNA double-strand break repair. Plays a role in regulating enhancer activation (By similarity). Recruits the PR-DUB complex to specific gene-regulatory regions (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements., [UniProtKB]; YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity. Publication Status: Online-Only, [RefSeq, PubMed]; YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle., [RefSeq, PubMed]; YY1-mediated enhancer-promoter communication in the immunoglobulin mu locus is regulated by MSL/MOF recruitment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031011 Ino80 complex;GO:0001650 fibrillar center", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q00899-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCN3-1", "uniprot_id": [ { "id": "TTBK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PCN3", "type": "external" } ], "mass": 141613.0, "length": 1308, "protein_name": "Tau-tubulin kinase 1", "gene_name": "Ttbk1", "organism": "Mouse", "refseq_name": "tau-tubulin kinase 1", "refseq_ac": [ { "id": "NP_001156336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156336", "type": "external" } ], "gene_names_uniprotkb": "Ttbk1", "gene_names_refseq": "C330008L01Rik; Ttbk1", "protein_names_uniprotkb": "Tau-tubulin kinase 1; 2.7.11.1", "protein_names_refseq": "tau-tubulin kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106763)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16923168;20354135;21183079;21750661;24418258;29187734;31219806;32019603;32255788;32424773;32891070", "class_list": "", "function": "Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease., [RefSeq, PubMed]; Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms., [RefSeq, PubMed]; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity)., [UniProtKB]; TTBK1 accelerates motor neuron neurodegeneration by recruiting proinflammatory monocytes and enhancing sensitivity to neurotoxicity in inflammatory conditions., [RefSeq, PubMed]; TTBK1 up-regulation enhances tau phosphorylation and oligomerization, whose toxicity results in enhanced neurodegeneration and locomotor dysfunction in a tauopathy animal model., [RefSeq, PubMed]; Tau-tubulin kinase 1 and amyloid-beta peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Publication Status: Online-Only, [RefSeq, PubMed]; The acute effects of TTBK1 inhibition on tau phosphorylation in vivo, is reported. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0048156 tau protein binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0007611 learning or memory;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0061890 positive regulation of astrocyte activation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6PCN3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGR6-1", "uniprot_id": [ { "id": "ARL15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGR6", "type": "external" } ], "mass": 22905.0, "length": 204, "protein_name": "ADP-ribosylation factor-like protein 15", "gene_name": "Arl15", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 15", "refseq_ac": [ { "id": "NP_766183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766183", "type": "external" } ], "gene_names_uniprotkb": "Arl15; Arfrp2", "gene_names_refseq": "A430036I03; Arfrp2; Arl15; C230032K13Rik", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 15; ADP-ribosylation factor-related protein 2; ARF-related protein 2", "protein_names_refseq": "ADP-ribosylation factor related protein 2; ADP-ribosylation factor-like protein 15; ARF-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:218639)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;28322786;29242557;37773757", "class_list": "", "function": "ARL15 plays a role in adipocyte differentiation and adiponectin secretion Publication Status: Online-Only, [RefSeq, PubMed]; Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout., [RefSeq, PubMed]; In conclusion, we have identified that ARL15 acts as an insulin-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1/AKT insulin pathway by interacting with its GAP ASAP2 and activating PDPK1. This research may provide new insights into GTPase-mediated insulin signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin sensitizati, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0016477 cell migration;GO:0060612 adipose tissue development;GO:0042445 hormone metabolic process;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1IGU4-1", "uniprot_id": [ { "id": "ARH37_MOUSE", "url": "https://www.uniprot.org/uniprot/A1IGU4", "type": "external" } ], "mass": 76524.0, "length": 676, "protein_name": "Rho guanine nucleotide exchange factor 37", "gene_name": "Arhgef37", "organism": "Mouse", "refseq_name": "rho guanine nucleotide exchange factor 37", "refseq_ac": [ { "id": "NP_808496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808496", "type": "external" } ], "gene_names_uniprotkb": "Arhgef37", "gene_names_refseq": "4933429F08Rik; Arhgef37", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 37", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 37; probable guanine nucleotide exchange factor FLJ41603 homolog; rho guanine nucleotide exchange factor 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:328967); (R-MMU-193648); (R-MMU-416482)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;30926623;31219806", "class_list": "", "function": "Probable guanine nucleotide exchange factor (GEF) involved in clathrin-mediated endocytosis, probably playing a role in the late stages of the process (PubMed:30926623)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0M3", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1IGU4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U214-1", "uniprot_id": [ { "id": "MAST3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U214", "type": "external" } ], "mass": 144174.0, "length": 1321, "protein_name": "Microtubule-associated serine/threonine-protein kinase 3", "gene_name": "Mast3", "organism": "Mouse", "refseq_name": "microtubule-associated serine/threonine-protein kinase 3 isoform 5", "refseq_ac": [ { "id": "NP_955012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955012", "type": "external" } ], "gene_names_uniprotkb": "Mast3; Kiaa0561", "gene_names_refseq": "Mast3; mKIAA0561", "protein_names_uniprotkb": "Microtubule-associated serine/threonine-protein kinase 3; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 3 isoform 5; microtubule-associated serine/threonine-protein kinase 3", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 108 (Disease Ontology:DOID:0070394)", "pathway": " (mmu:546071)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17242355;18650832;21183079;21750661;26192747;28167675;31219806;34185323;35820727", "class_list": "", "function": "As in human immune cells, murine Mast3 is constitutively expressed in CD4-positive and CD8-positive T cells and CD19-expressing B cells., [RefSeq, PubMed]; Serine/threonine kinase that phosphorylates ARPP19 at 'Ser-62', resulting in protein phosphatase 2A (PP2A) inhibition by ARPP19., [UniProtKB, UniProtKB]; We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ28;Q6A047", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3U214-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCR7-1", "uniprot_id": [ { "id": "ABHEB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCR7", "type": "external" } ], "mass": 22451.0, "length": 210, "protein_name": "Putative protein-lysine deacylase ABHD14B", "gene_name": "Abhd14b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Abhd14b", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative protein-lysine deacylase ABHD14B; 2.3.1.-; Abhydrolase domain-containing protein 14B; Alpha/beta hydrolase domain-containing protein 14B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76491); (R-MMU-156584)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;31599954;33725478;37453647", "class_list": "", "function": "Acts as an atypical protein-lysine deacetylase in vitro. Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues. Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo. Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate. May activate transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0016787 hydrolase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03141-1", "uniprot_id": [ { "id": "MARK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03141", "type": "external" } ], "mass": 84390.0, "length": 753, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "Mark3", "organism": "Mouse", "refseq_name": "MAP/microtubule affinity-regulating kinase 3 isoform 1", "refseq_ac": [ { "id": "NP_067491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067491", "type": "external" } ], "gene_names_uniprotkb": "Mark3; Emk2; Mpk10", "gene_names_refseq": "1600015G02Rik; A430080F22Rik; C-TAK1; ETK-1; ETK1; Emk2; MPK10; Mark3", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1; ELKL motif kinase 2; EMK-2; MPK-10", "protein_names_refseq": "ELKL motif kinase 2; EMK-2; EMK2/MARK3 serine-threonine protein kinase; MAP/microtubule affinity-regulating kinase 3 isoform 1; MPK-10", "tax_id": 10090, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:17169); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5675221); (R-MMU-9856649)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;1281307;12941695;17075132;17242355;21183079;21750661;22517741;22645316;25605945;28528544;32848054;33300544;33792563;34428180;34678516", "class_list": "", "function": "Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts., [RefSeq, PubMed]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM40;Q3V1U3;Q8C6G9;Q8R375;Q9JKE4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0019903 protein phosphatase binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:1900181 negative regulation of protein localization to nucleus;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03141-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RX14-1", "uniprot_id": [ { "id": "TUT4_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RX14", "type": "external" } ], "mass": 184650.0, "length": 1644, "protein_name": "Terminal uridylyltransferase 4", "gene_name": "Tut4", "organism": "Mouse", "refseq_name": "terminal uridylyltransferase 4 isoform 3", "refseq_ac": [ { "id": "NP_780681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780681", "type": "external" } ], "gene_names_uniprotkb": "Tut4; Kiaa0191; Zcchc11", "gene_names_refseq": "6030404K05Rik; 9230115F04Rik; PPAPD3; Tent3a; Tut4; Zcchc11; mKIAA0191", "protein_names_uniprotkb": "Terminal uridylyltransferase 4; 2.7.7.52; TUTase 4; Zinc finger CCHC domain-containing protein 11", "protein_names_refseq": "TUTase 4; terminal uridylyltransferase 4 isoform 3; terminal uridylyltransferase 4; zinc finger CCHC domain-containing protein 11; zinc finger, CCHC domain containing 11", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (mmu:230594)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;16643855;19144319;19701194;19703396;19713958;21183079;21750661;22898984;23209448;24129315;28671666;28792939;31219806;34428180;37085578;37828378", "class_list": "", "function": "Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells, [RefSeq, PubMed]; TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Publication Status: Online-Only, [RefSeq, PubMed]; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:28792939). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (PubMed:28792939). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (By similarity). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (By similarity). Does not play a role in replication-dependent histone mRNA degradation (By similarity). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:22898984, PubMed:28671666, PubMed:28792939). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; We conclude that the Zcchc11-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF-1 expression and enhancing postnatal growth and survival, [RefSeq, PubMed]; We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. Erratum:[Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121], [RefSeq, PubMed]; Zcchc11 fine tunes IL-6 production by uridylating miR-26a., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A8R8;Q3UYT6;Q5DU43", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035198 miRNA binding;GO:0070569 uridylyltransferase activity;GO:0050265 RNA uridylyltransferase activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0032755 positive regulation of interleukin-6 production;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0019827 stem cell population maintenance;GO:0001556 oocyte maturation;GO:0010586 miRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "B2RX14-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60841-1", "uniprot_id": [ { "id": "RELN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60841", "type": "external" } ], "mass": 387495.0, "length": 3461, "protein_name": "Reelin", "gene_name": "Reln", "organism": "Mouse", "refseq_name": "reelin isoform 2 precursor", "refseq_ac": [ { "id": "NP_001297393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297393", "type": "external" } ], "gene_names_uniprotkb": "Reln; Rl", "gene_names_refseq": "Reln; reeler; rl", "protein_names_uniprotkb": "Reelin; 3.4.21.-; Reeler protein", "protein_names_refseq": "extracellular matrix serine protease; reelin isoform 2 precursor", "tax_id": 10090, "disease": "familial temporal lobe epilepsy 7 (Disease Ontology:DOID:0060751); Norman-Roberts syndrome (Disease Ontology:DOID:0060902); Alzheimer's disease (Disease Ontology:DOID:10652); autistic disorder (Disease Ontology:DOID:12849); Down syndrome (Disease Ontology:DOID:14250); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:19699); (R-MMU-8866376)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10328932;10571241;10880573;11689558;16858396;17548821;21750661;21844191;25428506;30084848;30899004;34428180;7647795;7715726;8987733;9182958;9417911", "class_list": "", "function": "Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment (PubMed:10880573, PubMed:11689558, PubMed:7715726, PubMed:8987733). Regulates microtubule function in neurons and neuronal migration (PubMed:10880573, PubMed:7715726, PubMed:8987733). Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (PubMed:10571241). Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration (PubMed:11689558, PubMed:7715726, PubMed:8987733). Enzymatic activity is important for the modulation of cell adhesion (PubMed:11689558, PubMed:8987733)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 11, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "E9PZ78;Q9CUA6", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070325 lipoprotein particle receptor binding;GO:0048018 receptor ligand activity;GO:0070326 very-low-density lipoprotein particle receptor binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q60841-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10852-1", "uniprot_id": [ { "id": "4F2_MOUSE", "url": "https://www.uniprot.org/uniprot/P10852", "type": "external" } ], "mass": 58337.0, "length": 526, "protein_name": "Amino acid transporter heavy chain SLC3A2", "gene_name": "Slc3a2", "organism": "Mouse", "refseq_name": "amino acid transporter heavy chain SLC3A2 isoform a", "refseq_ac": [ { "id": "NP_001154885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154885", "type": "external" } ], "gene_names_uniprotkb": "Slc3a2; Mdu1", "gene_names_refseq": "4F2HC; 4F2; Cd98; Ly-10; Ly-m10; Ly10; Mdu1; Mgp-2hc; NACAE; Slc3a2", "protein_names_uniprotkb": "Amino acid transporter heavy chain SLC3A2; 4F2 cell-surface antigen heavy chain; 4F2hc; Solute carrier family 3 member 2", "protein_names_refseq": "4F2 cell-surface antigen heavy chain; CD98 antigen; CD98 heavy chain; amino acid transporter heavy chain SLC3A2 isoform a; amino acid transporter heavy chain SLC3A2; antigen identified by monoclonal antibodies 4F2; solute carrier family 3 member 2; type II transmembrane protein", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung pleomorphic carcinoma (Disease Ontology:DOID:0080899); transitional cell carcinoma (Disease Ontology:DOID:2671); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:17254); (R-MMU-210991); (R-MMU-352230); (R-MMU-71240)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10574970;10734121;11011012;12927796;16075062;19144319;19349973;19656770;21183079;21750661;25605945;27802388;28528544;29187734;2928113;30084848;30779550;30899004;30958588;33300544;34428180;37771765;38519468;39627609;9915839", "class_list": "glycogene;glycosylhydrolase", "function": "Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10734121, PubMed:11011012, PubMed:9915839). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE[-/-]mice. Publication Status: Online-Only, [RefSeq, PubMed]; Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "G3UWA6;Q54AH5", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:1903801 L-leucine import across plasma membrane;GO:0005975 carbohydrate metabolic process;GO:0015804 neutral amino acid transport", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P10852-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70423-1", "uniprot_id": [ { "id": "AOC3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70423", "type": "external" } ], "mass": 84534.0, "length": 765, "protein_name": "Amine oxidase [copper-containing] 3", "gene_name": "Aoc3", "organism": "Mouse", "refseq_name": "amine oxidase [copper-containing] 3", "refseq_ac": [ { "id": "NP_033805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033805", "type": "external" } ], "gene_names_uniprotkb": "Aoc3; Vap1", "gene_names_refseq": "Aoc3; SSAO; VAP1", "protein_names_uniprotkb": "Amine oxidase [copper-containing] 3; 1.4.3.21; Amine oxidase copper-containing 3; Copper amine oxidase; SSAO; Semicarbazide-sensitive amine oxidase; VAP-1; Vascular adhesion protein 1", "protein_names_refseq": "VAP-1; amine oxidase [copper-containing] 3; copper amine oxidase; membrane primary amine oxidase; semicarbazide-sensitive amine oxidase; vascular adhesion protein 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); uveitis (Disease Ontology:DOID:13141); aortic aneurysm (Disease Ontology:DOID:3627); congestive heart failure (Disease Ontology:DOID:6000); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11754); (R-MMU-211945)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10092636;12242458;12606817;21750661;25428506;30084848;30199530;30779550;32410850;32712883;34428180;36210013;36825552;37507081;39187313;9743358", "class_list": "", "function": "Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis., [RefSeq, PubMed]; Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction., [RefSeq, PubMed]; Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion., [UniProtKB, UniProtKB]; Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1. Publication Status: Online-Only, [RefSeq, PubMed]; Enzyme is in involved in deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet., [RefSeq, PubMed]; Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity., [RefSeq, PubMed]; The increased enzyme activity observed in diabetes is not a result of increased SSAO gene transcription. It is controlled by posttranslational modifications of the protein, and the catalytic activity controls the gene expression, [RefSeq, PubMed]; The results establish a role for Copper homeostasis in adipocyte metabolism and identify SSAO as a regulator of energy utilization processes in adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 10, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A4I7;Q66JM4;Q9R055", "ec_number_list": [ { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007155 cell adhesion;GO:0008217 regulation of blood pressure;GO:0042755 eating behavior;GO:0002523 leukocyte migration involved in inflammatory response;GO:0002675 positive regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O70423-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58749-1", "uniprot_id": [ { "id": "TM6S1_MOUSE", "url": "https://www.uniprot.org/uniprot/P58749", "type": "external" } ], "mass": 41662.0, "length": 370, "protein_name": "Transmembrane 6 superfamily member 1", "gene_name": "Tm6sf1", "organism": "Mouse", "refseq_name": "transmembrane 6 superfamily member 1 isoform 2", "refseq_ac": [ { "id": "NP_001278211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278211", "type": "external" } ], "gene_names_uniprotkb": "Tm6sf1", "gene_names_refseq": "C630016D09Rik; Tm6sf1", "protein_names_uniprotkb": "Transmembrane 6 superfamily member 1", "protein_names_refseq": "transmembrane 6 superfamily member 1 isoform 2", "tax_id": 10090, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:107769)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20173027;21750661;25422095;34428180", "class_list": "", "function": "May function as sterol isomerase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUN7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P58749-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K442-1", "uniprot_id": [ { "id": "ABC8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K442", "type": "external" } ], "mass": 184180.0, "length": 1620, "protein_name": "ABC-type organic anion transporter ABCA8A", "gene_name": "Abca8a", "organism": "Mouse", "refseq_name": "ABC-type organic anion transporter ABCA8A isoform 1", "refseq_ac": [ { "id": "NP_694785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694785", "type": "external" } ], "gene_names_uniprotkb": "Abca8a", "gene_names_refseq": "Abca8a", "protein_names_uniprotkb": "ABC-type organic anion transporter ABCA8A; 7.6.2.-; ATP-binding cassette sub-family A member 8A", "protein_names_refseq": "ABC-type organic anion transporter ABCA8A isoform 1; ABC-type organic anion transporter ABCA8A; ATP-binding cassette sub-family A member 8-A; ATP-binding cassette, sub-family A (ABC1), member 8a", "tax_id": 10090, "disease": "", "pathway": " (mmu:217258)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12532264;16445568;21750661;28882873;29300488;34428180;35820727", "class_list": "", "function": "ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels., [RefSeq, PubMed]; Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AB96;Q6PAV3;Q8C0A9;Q8R0R4", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006869 lipid transport;GO:0010875 positive regulation of cholesterol efflux;GO:0033344 cholesterol efflux;GO:0030301 cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K442-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J72-1", "uniprot_id": [ { "id": "ABEC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J72", "type": "external" } ], "mass": 52213.0, "length": 440, "protein_name": "DNA dC->dU-editing enzyme APOBEC-3", "gene_name": "Apobec3", "organism": "Mouse", "refseq_name": "DNA dC->dU-editing enzyme APOBEC-3 isoform X1", "refseq_ac": [ { "id": "XP_017172295", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017172295", "type": "external" } ], "gene_names_uniprotkb": "Apobec3", "gene_names_refseq": "Apobec3; Apobec; Arp3; Cem15; Gm20117; Rfv3", "protein_names_uniprotkb": "DNA dC->dU-editing enzyme APOBEC-3; 3.5.4.38; Apolipoprotein B mRNA-editing complex 3; Arp3; CEM-15; CEM15", "protein_names_refseq": "DNA dC->dU-editing enzyme APOBEC-3 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:80287); (R-MMU-72200); (R-MMU-75094)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12859895;16378963;16527742;17020885;17259974;18304004;18786991;21750661;29187734;31219806;34428180", "class_list": "", "function": "DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H3BJL0;Q8C7L0;Q8C8V7", "ec_number_list": [ { "id": "3.5.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.-", "type": "external" }, { "id": "3.5.4.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.36", "type": "external" }, { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus;GO:0070383 DNA cytosine deamination;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99J72-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFS9-1", "uniprot_id": [ { "id": "ASND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFS9", "type": "external" } ], "mass": 69753.0, "length": 627, "protein_name": "Asparagine synthetase domain-containing protein 1", "gene_name": "Asnsd1", "organism": "Mouse", "refseq_name": "asparagine synthetase domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_598489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598489", "type": "external" } ], "gene_names_uniprotkb": "Asnsd1", "gene_names_refseq": "2210409M21Rik; Asnsd1", "protein_names_uniprotkb": "Asparagine synthetase domain-containing protein 1", "protein_names_refseq": "asparagine synthetase domain-containing protein 1 isoform 1; asparagine synthetase domain-containing protein 1", "tax_id": 10090, "disease": "myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:70396)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THX2;Q3U2Y8;Q3U317;Q8BM66;Q91YY3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0060612 adipose tissue development;GO:0007517 muscle organ development;GO:0070981 L-asparagine biosynthetic process;GO:0060290 transdifferentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BFS9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QMK6-1", "uniprot_id": [ { "id": "AL3B3_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QMK6", "type": "external" } ], "mass": 53120.0, "length": 479, "protein_name": "Aldehyde dehydrogenase family 3 member B3", "gene_name": "Aldh3b3", "organism": "Mouse", "refseq_name": "aldehyde dehydrogenase family 3 member B3", "refseq_ac": [ { "id": "NP_082821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082821", "type": "external" } ], "gene_names_uniprotkb": "Aldh3b3; 1700055N04Rik", "gene_names_refseq": "1700055N04Rik; Aldh3b3", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member B3; 1.2.1.3", "protein_names_refseq": "aldehyde dehydrogenase family 3 member B3", "tax_id": 10090, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (mmu:73458)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25286108;25428506", "class_list": "", "function": "Oxidizes medium and long chain aldehydes into non-toxic fatty acids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9K6", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "J3QMK6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KAU8-1", "uniprot_id": [ { "id": "A16L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6KAU8", "type": "external" } ], "mass": 69241.0, "length": 623, "protein_name": "Protein Atg16l2", "gene_name": "Atg16l2", "organism": "Mouse", "refseq_name": "protein Atg16l2", "refseq_ac": [ { "id": "NP_001104581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104581", "type": "external" } ], "gene_names_uniprotkb": "Atg16l2", "gene_names_refseq": "2410118P20Rik; Atg16l2", "protein_names_uniprotkb": "Protein Atg16l2; APG16-like 2; Autophagy-related protein 16-2", "protein_names_refseq": "APG16-like 2; Atg16L2 alpha; Atg16L2 beta; autophagy-related 16-like 2 alpha; autophagy-related 16-like 2 beta; autophagy-related protein 16-2; mFLJ00012 protein; protein Atg16l2", "tax_id": 10090, "disease": "inflammatory bowel disease 10 (Disease Ontology:DOID:0110885)", "pathway": " (mmu:73683); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;22082872;24089209;31451676;35426127;39175123", "class_list": "", "function": "ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy., [RefSeq, PubMed]; Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association., [RefSeq, PubMed]; May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner., [UniProtKB, PubMed]; Results show that ATG16L1 and ATG16L2 contribute very distinctly to autophagy and cellular ontogeny in myeloid, lymphoid, and epithelial lineages. Dysregulation of any of these lineages could contribute to complex diseases like Crohn disease and systemic lupus erythematosus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z653;G9M4M8;Q6PAU0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0034274 Atg12-Atg5-Atg16 complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0039689 negative stranded viral RNA replication;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6KAU8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EST3-1", "uniprot_id": [ { "id": "4ET_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EST3", "type": "external" } ], "mass": 107986.0, "length": 983, "protein_name": "Eukaryotic translation initiation factor 4E transporter", "gene_name": "Eif4enif1", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E transporter isoform a", "refseq_ac": [ { "id": "NP_001160019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160019", "type": "external" } ], "gene_names_uniprotkb": "Eif4enif1; Clast4", "gene_names_refseq": "2610509L04Rik; A930019J01Rik; Clast4; D11Ertd166e; Eif4enif1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E transporter; 4E-T; CD40 ligand-activated specific transcript 4; Eukaryotic translation initiation factor 4E nuclear import factor 1; eIF4E transporter", "protein_names_refseq": "4E-T; CD40 ligand-activated specific transcript 4; eIF4E transporter; eukaryotic translation initiation factor 4E transporter isoform a; eukaryotic translation initiation factor 4E transporter", "tax_id": 10090, "disease": "", "pathway": " (mmu:74203)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16343815;19144319;21183079;21750661;22517741;25428506;25456498;30779550;31219806;31599954;32782141;34887587;36757814;36852467;38088064", "class_list": "", "function": "EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:25456498). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (PubMed:25456498). Promotes miRNA-mediated translational repression (By similarity). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (By similarity). Required for the formation of P-bodies (By similarity). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (By similarity)., [UniProtKB, UniProtKB, PubMed]; Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFW0;Q9CSS3", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019900 kinase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000932 P-body", "go_biological_process": "GO:0045665 negative regulation of neuron differentiation;GO:0048255 mRNA stabilization;GO:0017148 negative regulation of translation;GO:0019827 stem cell population maintenance;GO:0035278 miRNA-mediated gene silencing by inhibition of translation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9EST3-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04627-1", "uniprot_id": [ { "id": "ARAF_MOUSE", "url": "https://www.uniprot.org/uniprot/P04627", "type": "external" } ], "mass": 67581.0, "length": 604, "protein_name": "Serine/threonine-protein kinase A-Raf", "gene_name": "Araf", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase A-Raf isoform 2", "refseq_ac": [ { "id": "NP_001153117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153117", "type": "external" } ], "gene_names_uniprotkb": "Araf; A-raf; Araf1", "gene_names_refseq": "1200013E08Rik; A-Raf; Araf1; Araf", "protein_names_uniprotkb": "Serine/threonine-protein kinase A-Raf; 2.7.11.1; Proto-oncogene A-Raf", "protein_names_refseq": "A-Raf proto-oncogene serine/threonine-protein kinase; proto-oncogene A-Raf; raf-related oncogene; serine/threonine-protein kinase A-Raf isoform 2; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cancer (Disease Ontology:DOID:162); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:11836); (R-MMU-5673000); (R-MMU-5674135); (R-MMU-5675221)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "21183079;21750661;28743549;30742807;31219806;32848054;34428180;3491291;37858158;40021952", "class_list": "", "function": "DA-Raf1 (DA-Raf) is a splicing variant of A-Raf that suppresses the Ras-ERK pathway and is essential for both myocyte differentiation including myoblast fusion and apoptosis but apoptosis is not a prerequisite for myoblast fusion, [RefSeq, PubMed]; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Phosphorylates PFKFB2 (By similarity)., [UniProtKB, UniProtKB]; PKM1 interacts with A-Raf, an upstream regulator of the MEK/ERK pathway, and that this interaction contributes to MEK1 phosphorylation by A-Raf., [RefSeq, PubMed]; Toxoplasma gondii infection regulates apoptosis of host cells via miR-185/ARAF axis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AUN9;Q99J44;Q9CTT5;Q9D6R6;Q9DBU7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0000165 MAPK cascade;GO:0032006 regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P04627-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7ZCC9-1", "uniprot_id": [ { "id": "AGRG4_MOUSE", "url": "https://www.uniprot.org/uniprot/B7ZCC9", "type": "external" } ], "mass": 334211.0, "length": 3073, "protein_name": "Adhesion G protein-coupled receptor G4", "gene_name": "Adgrg4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adgrg4; Gpr112", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G4; G protein-coupled receptor 112", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "21750661;31219806;34418053;35820727", "class_list": "", "function": "Orphan adhesion G protein-coupled receptor (aGPCR). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG4 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May be act as sensor of mechanical forces (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 5, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B7ZCD0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B7ZCC9-1", "record_type": "protein", "filter_code": "0000000.1000100.001000.000000000000100000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UEI1-1", "uniprot_id": [ { "id": "PDE4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UEI1", "type": "external" } ], "mass": 76090.0, "length": 686, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 4C", "gene_name": "Pde4c", "organism": "Mouse", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4C isoform 1", "refseq_ac": [ { "id": "NP_001297394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297394", "type": "external" } ], "gene_names_uniprotkb": "Pde4c", "gene_names_refseq": "Dpde1; E130301F19Rik; Pde4c; dunce", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 4C; 3.1.4.53; cAMP-specific phosphodiesterase 4C", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4C isoform 1; 3',5'-cyclic-AMP phosphodiesterase 4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific phosphodiesterase 4C", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:110385); (R-MMU-180024); (R-MMU-418555)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21183079;21670265;21750661", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0P4", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0007165 signal transduction;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UEI1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505B7-1", "uniprot_id": [ { "id": "ARCH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q505B7", "type": "external" } ], "mass": 19727.0, "length": 168, "protein_name": "tRNA-splicing ligase-activating factor archease", "gene_name": "Zbtb8os", "organism": "Mouse", "refseq_name": "tRNA-splicing ligase-activating factor archease", "refseq_ac": [ { "id": "NP_080246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080246", "type": "external" } ], "gene_names_uniprotkb": "Zbtb8os", "gene_names_refseq": "2010001H09Rik; 2310028N13Rik; Archm; Arch; Zbtb8os", "protein_names_uniprotkb": "tRNA-splicing ligase-activating factor archease; 2.7.7.-", "protein_names_refseq": "archease (Arch); protein archease; tRNA-splicing ligase-activating factor archease", "tax_id": 10090, "disease": "", "pathway": " (mmu:67106)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15162483;21750661;34428180", "class_list": "", "function": "Activation factor of RTCB, the catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation. Catalyzes the GTP-dependent activation of RTCB, both proteins forming a composite active site coordinating GTP and metal ions to enable the guanylylation of RTCB a prerequisite to undergo multiple catalytic cycles. Also required for the activation of RTCB in non-canonical, spliceosome-independent, cytoplasmic splicing of XBP1 mRNAs during the unfolded protein response (UPR). Upon endoplasmic reticulum (ER) stress, the endoribonuclease IRE1/ERN1 excises a short intron, generating free exon ends that are aligned by RNA-intrinsic, zipper-like stem-loop structures. These exon ends are then recognized and ligated by RTCB. This splicing event yields the active XBP1s transcription factor, which induces genes required to resolve protein folding defects in the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0S8;Q9CQ53;Q9D770", "ec_number_list": [ { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044600 protein guanylyltransferase activity;GO:0170057 RNA ligase (GTP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072669 tRNA-splicing ligase complex;GO:1902494 catalytic complex", "go_biological_process": "GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:0036498 IRE1-mediated unfolded protein response;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation;GO:0000968 tRNA exon ligation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q505B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01339-1", "uniprot_id": [ { "id": "APOH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01339", "type": "external" } ], "mass": 38619.0, "length": 345, "protein_name": "Beta-2-glycoprotein 1", "gene_name": "Apoh", "organism": "Mouse", "refseq_name": "beta-2-glycoprotein 1 precursor", "refseq_ac": [ { "id": "NP_038503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038503", "type": "external" } ], "gene_names_uniprotkb": "Apoh; B2gp1", "gene_names_refseq": "Apoh; B2GPI; beta-2-GPI; beta2-GPI", "protein_names_uniprotkb": "Beta-2-glycoprotein 1; APC inhibitor; Activated protein C-binding protein; Apo-H; Apolipoprotein H; B2GPI; Beta(2)GPI; Beta-2-glycoprotein I", "protein_names_refseq": "APC inhibitor; activated protein C-binding protein; apo-H; beta(2)GPI; beta-2-glycoprotein 1 precursor; beta-2-glycoprotein 1; beta-2-glycoprotein I", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); thrombosis (Disease Ontology:DOID:0060903); arteriosclerosis (Disease Ontology:DOID:2349); antiphospholipid syndrome (Disease Ontology:DOID:2988); peripheral vascular disease (Disease Ontology:DOID:341); macular retinal edema (Disease Ontology:DOID:4449); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11818); (R-MMU-114608)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;1339387;16944957;17330941;20571061;21750661;23386199;30084848;34428180;37507081;38101620;38271349;39353906;39627609;7514402", "class_list": "", "function": "Beta2-glycoprotein I promotes the clearance of circulating mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells., [UniProtKB]; Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis., [RefSeq, PubMed]; Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition. Erratum:[Cell Death Dis. 2024 Dec 3;15(12):875. doi: 10.1038/s41419-024-07181-9. PMID: 39627207] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 10, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0035473 lipase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0010898 positive regulation of triglyceride catabolic process;GO:0051918 negative regulation of fibrinolysis;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q01339-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U9G9-1", "uniprot_id": [ { "id": "LBR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U9G9", "type": "external" } ], "mass": 71440.0, "length": 626, "protein_name": "Delta(14)-sterol reductase LBR", "gene_name": "Lbr", "organism": "Mouse", "refseq_name": "delta(14)-sterol reductase LBR isoform 1", "refseq_ac": [ { "id": "NP_598576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598576", "type": "external" } ], "gene_names_uniprotkb": "Lbr", "gene_names_refseq": "C14SR; Lbr; ic", "protein_names_uniprotkb": "Delta(14)-sterol reductase LBR; 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta-14-SR; Integral nuclear envelope inner membrane protein; Lamin-B receptor; Sterol C14-reductase", "protein_names_refseq": "3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; delta(14)-sterol reductase LBR isoform 1; delta(14)-sterol reductase LBR; delta-14-SR; ichthyosis; integral nuclear envelope inner membrane protein; sterol C14-reductase", "tax_id": 10090, "disease": "Greenberg dysplasia (Disease Ontology:DOID:0111588); primary biliary cholangitis (Disease Ontology:DOID:12236); ichthyosis vulgaris (Disease Ontology:DOID:1702); systemic lupus erythematosus (Disease Ontology:DOID:9074); Pelger-Huet anomaly (Disease Ontology:DOID:9631)", "pathway": " (mmu:98386); (R-MMU-2995383); (R-MMU-6807047); (R-MMU-8980692); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9022692)", "pathway_count": 11, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12438562;12490533;18785926;19144319;21183079;21327084;21750661;22140257;22645316;25605945;26009488;31219806;34428180;35820727;36210013", "class_list": "", "function": "Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:18785926). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (PubMed:22140257). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (PubMed:22140257). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSW2;Q811V8;Q811V9;Q8BST3;Q8K2Y8;Q8VDM0;Q91YS5;Q91Z27", "ec_number_list": [ { "id": "1.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.21", "type": "external" }, { "id": "3.3.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.11", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0051087 protein-folding chaperone binding;GO:0070402 NADPH binding;GO:0008139 nuclear localization sequence binding;GO:0070087 chromo shadow domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0060816 random inactivation of X chromosome;GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0036197 zymosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3U9G9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K448-1", "uniprot_id": [ { "id": "ABCA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K448", "type": "external" } ], "mass": 185895.0, "length": 1642, "protein_name": "Cholesterol transporter ABCA5", "gene_name": "Abca5", "organism": "Mouse", "refseq_name": "cholesterol transporter ABCA5", "refseq_ac": [ { "id": "NP_671752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671752", "type": "external" } ], "gene_names_uniprotkb": "Abca5; Kiaa1888", "gene_names_refseq": "ABC13; Abca5; B930033A02Rik; mKIAA1888", "protein_names_uniprotkb": "Cholesterol transporter ABCA5; 7.6.2.-; ATP-binding cassette sub-family A member 5", "protein_names_refseq": "ATP-binding cassette transporter sub-family A member 5; ATP-binding cassette, sub-family A (ABC1), member 5; cholesterol transporter ABCA5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217265); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12532264;15870284;16445568;20382126;21750661;24831815;25125465;25428506;32687853;34203471;34428180;35820727;37828378", "class_list": "", "function": "ABCA5 influences macrophage cholesterol efflux, and selective disruption of ABCA5 in macrophages leads to increased atherosclerotic lesion development in female LDLr(-/-) mice., [RefSeq, PubMed]; ABCA5 is a protein related to a lysosomal disease and plays important roles, especially in cardiomyocytes and follicular cells Erratum:[Mol Cell Biol. 2005 Jul;25(13):5786], [RefSeq, PubMed]; Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:20382126, PubMed:25125465, PubMed:32687853). May play a role in the processing of autolysosomes (PubMed:15870284)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE17;Q3UUB4;Q6P1Y0;Q6ZPG4;Q810C7;Q8BM46;Q8BXG7", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0010745 negative regulation of macrophage derived foam cell differentiation;GO:0033344 cholesterol efflux;GO:0034375 high-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K448-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MP8-1", "uniprot_id": [ { "id": "BRAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MP8", "type": "external" } ], "mass": 66991.0, "length": 591, "protein_name": "BRCA1-associated protein", "gene_name": "Brap", "organism": "Mouse", "refseq_name": "BRCA1-associated protein isoform 3", "refseq_ac": [ { "id": "NP_001276473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276473", "type": "external" } ], "gene_names_uniprotkb": "Brap", "gene_names_refseq": "3010002G07Rik; BRAP2; Brap; IMP", "protein_names_uniprotkb": "BRCA1-associated protein; 2.3.2.27; BRAP2; IMP; Impedes mitogenic signal propagation; RING-type E3 ubiquitin transferase BRAP2", "protein_names_refseq": "BRCA1-associated protein isoform 3; RING-type E3 ubiquitin transferase BRAP2; impedes mitogenic signal propagation", "tax_id": 10090, "disease": "", "pathway": " (mmu:72399); (R-MMU-5673000); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "14607334;18577512;21750661;23673330;26495903;31219806;34428180;37715941;38169666", "class_list": "", "function": "A molecular complex composed of Nde1, Lis1, and Brap regulates the dynamic MAPK signaling threshold in a spatially dependent fashion., [RefSeq, PubMed]; Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia., [RefSeq, PubMed]; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity)., [UniProtKB, UniProtKB]; P21 Ras/Imp regulate cytokine production and migration in CD4 T cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC00;Q8CHX1;Q99MP7;Q9CXX8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000165 MAPK cascade;GO:0007265 Ras protein signal transduction;GO:0016567 protein ubiquitination;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99MP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D387-1", "uniprot_id": [ { "id": "LAMP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D387", "type": "external" } ], "mass": 31721.0, "length": 280, "protein_name": "Lysosome-associated membrane glycoprotein 5", "gene_name": "Lamp5", "organism": "Mouse", "refseq_name": "lysosome-associated membrane glycoprotein 5 precursor", "refseq_ac": [ { "id": "NP_083806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083806", "type": "external" } ], "gene_names_uniprotkb": "Lamp5; 6330527O06Rik", "gene_names_refseq": "3110035N03Rik; 6330527O06Rik; BAD-LAMP; LAMP-5; Lamp5", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 5; BAD-LAMP; Brain and dendritic cell-associated LAMP; Brain-associated LAMP-like protein; LAMP-5; Lysosome-associated membrane protein 5", "protein_names_refseq": "LAMP family protein C20orf103 homolog; Protein C20orf103; brain and dendritic cell-associated LAMP; brain-associated LAMP-like protein; lysosome-associated membrane glycoprotein 5 precursor; lysosome-associated membrane glycoprotein 5; lysosome-associated membrane protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76161)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17215451;21750661;27272053;30899004;34428180", "class_list": "", "function": "Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8836, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXQ4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D387-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17047-1", "uniprot_id": [ { "id": "LAMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P17047", "type": "external" } ], "mass": 45681.0, "length": 415, "protein_name": "Lysosome-associated membrane glycoprotein 2", "gene_name": "Lamp2", "organism": "Mouse", "refseq_name": "lysosome-associated membrane glycoprotein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001017959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017959", "type": "external" } ], "gene_names_uniprotkb": "Lamp2; Lamp-2", "gene_names_refseq": "CD107b; LGP-B; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c; Lamp-2; Lamp2; Mac3", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B; LAMP-2; LGP-B; Lysosomal membrane glycoprotein type B; Lysosome-associated membrane protein 2", "protein_names_refseq": "CD107 antigen-like family member B; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosome-associated membrane glycoprotein 2 isoform 1 precursor; lysosome-associated membrane glycoprotein 2", "tax_id": 10090, "disease": "Danon disease (Disease Ontology:DOID:0050437); traumatic brain injury (Disease Ontology:DOID:0081292); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); cholestasis (Disease Ontology:DOID:13580); cognitive disorder (Disease Ontology:DOID:1561); chronic conjunctivitis (Disease Ontology:DOID:2475); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16784); (R-MMU-114608); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10972293;11082038;12221139;2142158;22641697;2318880;26495903;26740625;27628032;27663661;29187734;30084848;30718432;30899004;33300544;37828378;38744829;39627609;7546292", "class_list": "glycogene", "function": "Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:10972293, PubMed:30718432). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:30718432). Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation (PubMed:30718432). In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity). Plays a role in lysosomal protein degradation in response to starvation (PubMed:27628032). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:10972293, PubMed:12221139). Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits (By similarity). Is not required for efficient MHC class II-mediated presentation of endogenous antigens (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 3, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 14, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 14, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 21, "disease_count": 8, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "A2A430;Q3TXG5;Q8BSG8", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0035591 signaling adaptor activity;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0061684 chaperone-mediated autophagy;GO:0046716 muscle cell cellular homeostasis;GO:0006605 protein targeting;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P17047-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNG8-1", "uniprot_id": [ { "id": "LDHD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNG8", "type": "external" } ], "mass": 51848.0, "length": 484, "protein_name": "D-lactate dehydrogenase, mitochondrial", "gene_name": "Ldhd", "organism": "Mouse", "refseq_name": "D-lactate dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_081846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081846", "type": "external" } ], "gene_names_uniprotkb": "Ldhd; mLDHD", "gene_names_refseq": "4733401P21Rik; D8Bwg1320e; DLD; Ldhd", "protein_names_uniprotkb": "D-lactate dehydrogenase, mitochondrial; 1.1.98.-; DLD; Lactate dehydrogenase D", "protein_names_refseq": "D-lactate dehydrogenase, mitochondrial; probable D-lactate dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:52815); (R-MMU-1268020); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12127981;23576753;23806337;31638601;34428180;37453647;37863926", "class_list": "", "function": "Gout can be caused by a mutation in LDHD within the putative catalytic site of the encoded d-lactate dehydrogenase, resulting in augmented blood levels of d-lactate, a stereoisomer of l-lactate, [RefSeq, PubMed]; The mitochondrial D-lactate dehydrogenase is a stereoselective dehydrogenase that targets a wide variety of D-2-hydroxyacids, particularly those with small to moderately sized hydrophobic groups attached to the C2 atom. It includes D-lactate which is generated in small amounts either endogenously through the methylglyoxal metabolism pathway or exogenously via intestinal bacterial activity and dietary intake. The dehydrogenase acts specifically on D-lactate, not on its stereoisomer L-lactate, and prevents the toxic accumulation of D-lactate in the organism. By converting branched-chain D-2-hydroxyacids into branched-chain ketoacids, it may indirectly regulate branched-chain amino acid metabolism., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYU7;Q8CIV4", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.1.98.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.98.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004458 D-lactate dehydrogenase (cytochrome) activity;GO:0004457 lactate dehydrogenase activity;GO:0008720 D-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:1903457 lactate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TNG8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHS3-1", "uniprot_id": [ { "id": "LTOR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHS3", "type": "external" } ], "mass": 13480.0, "length": 125, "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "Lamtor2", "organism": "Mouse", "refseq_name": "ragulator complex protein LAMTOR2 isoform 1", "refseq_ac": [ { "id": "NP_112538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112538", "type": "external" } ], "gene_names_uniprotkb": "Lamtor2; Mapbpip; Robld3", "gene_names_refseq": "2010111E04Rik; Lamtor2; Mapbpip; P14; Rab25; Robld3", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR2; Endosomal adaptor protein p14; Late endosomal/lysosomal Mp1-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; Mitogen-activated protein-binding protein-interacting protein; Roadblock domain-containing protein 3", "protein_names_refseq": "endosomal adaptor protein p14; late endosomal/lysosomal MP1 interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; mitogen-activated protein-binding protein-interacting protein; ragulator complex protein LAMTOR2 isoform 1; ragulator complex protein LAMTOR2; roadblock domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:83409); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-5674135); (R-MMU-6798695); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "11266467;15016825;15263099;15740743;19177150;21750661;25336251;26024833;30936881;31423582;32152506;34428180;35732604", "class_list": "", "function": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (By similarity). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (PubMed:15263099)., [UniProtKB, PubMed, UniProtKB]; Data report the three-dimensional solution structure of the adaptor protein p14, which includes a profilin-like fold with a central five-stranded beta-sheet sandwiched between alpha-helices., [RefSeq, PubMed]; Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC., [RefSeq, PubMed]; LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; LAMTOR2 has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR signalling Publication Status: Online-Only, [RefSeq, PubMed]; LAMTOR2 regulates lipid metabolism in macrophages and foam cell differentiation., [RefSeq, PubMed]; Spatial regulation of MAPK signaling, illustrating how p14 and MP1 collaborate as an endosomal adaptor/scaffold complex, [RefSeq, PubMed]; [LAMTOR2 deficiency exacerbates Klebsiella pneumoniae-induced liver sepsis in mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0043410 positive regulation of MAPK cascade;GO:0001558 regulation of cell growth;GO:0032008 positive regulation of TOR signaling;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JHS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VN0-1", "uniprot_id": [ { "id": "LRP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VN0", "type": "external" } ], "mass": 178885.0, "length": 1614, "protein_name": "Low-density lipoprotein receptor-related protein 5", "gene_name": "Lrp5", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 5 precursor", "refseq_ac": [ { "id": "NP_032539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032539", "type": "external" } ], "gene_names_uniprotkb": "Lrp5; Lr3; Lrp7", "gene_names_refseq": "BMND1; HBM; LR3; LRP7; Lrp5; OPPG; mKIAA4142", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 5; LRP-5; LRP-7; Low-density lipoprotein receptor-related protein 7", "protein_names_refseq": "LRP-5; LRP-7; low-density lipoprotein receptor-related protein 5 precursor; low-density lipoprotein receptor-related protein 7", "tax_id": 10090, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); nonsyndromic deafness (Disease Ontology:DOID:0050563); osteoporosis-pseudoglioma syndrome (Disease Ontology:DOID:0060849); polycystic liver disease 4 (Disease Ontology:DOID:0060977); polycystic liver disease 1 (Disease Ontology:DOID:0060980); Worth syndrome (Disease Ontology:DOID:0080037); autosomal dominant osteopetrosis 1 (Disease Ontology:DOID:0110937); exudative vitreoretinopathy 4 (Disease Ontology:DOID:0111411); osteonecrosis (Disease Ontology:DOID:10159); microphthalmia (Disease Ontology:DOID:10629); osteoporosis (Disease Ontology:DOID:11476); idiopathic juvenile osteoporosis (Disease Ontology:DOID:12559); heart valve disease (Disease Ontology:DOID:4079); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); tendinitis (Disease Ontology:DOID:971); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (mmu:16973); (R-MMU-3772470); (R-MMU-4641262); (R-MMU-4641263)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10049586;11719191;11956231;12581525;15142971;21750661;25428506;26495903;26740625;28011936;28935714;31599954;34428180;35822049;35984892;38594269;38928468;9714764", "class_list": "", "function": "Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11956231). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (PubMed:15142971). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11956231). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (By similarity). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (By similarity). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (PubMed:11956231)., [UniProtKB, UniProtKB, PubMed, PubMed]; Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, [RefSeq, PubMed]; LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments. Publication Status: Online-Only, [RefSeq, PubMed]; Unique Splicing of Lrp5 in the Brain: A New Player in Neurodevelopment and Brain Maturation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ75;O88883;Q9R208", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0060042 retina morphogenesis in camera-type eye;GO:0060856 establishment of blood-brain barrier;GO:0006897 endocytosis;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q91VN0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG70-1", "uniprot_id": [ { "id": "P3H3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG70", "type": "external" } ], "mass": 81701.0, "length": 732, "protein_name": "Prolyl 3-hydroxylase 3", "gene_name": "P3h3", "organism": "Mouse", "refseq_name": "prolyl 3-hydroxylase 3 precursor", "refseq_ac": [ { "id": "NP_038562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038562", "type": "external" } ], "gene_names_uniprotkb": "P3h3; Leprel2", "gene_names_refseq": "Grcb; Leprel2; P3h3", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 3; 1.14.11.7; Leprecan-like protein 2; Protein B", "protein_names_refseq": "gene rich cluster, B; leprecan-like protein 2; prolyl 3-hydroxylase 3 precursor; protein B", "tax_id": 10090, "disease": "", "pathway": " (mmu:14789); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15044469;15063763;18798549;19652424;21750661;27119146;28115524;30084848;31219806;33631195;9445485", "class_list": "glycogene", "function": "Both P3h3- and Sc65-null mice displayed a similar pattern of severe under-hydroxylation of lysines, particularly at cross-linking sites in type I collagen from bone, skin, dentin, cornea, and aorta, revealing a complex evolution and interplay between the proteins forming the machinery of collagen prolyl 3-hydroxylation and lysyl hydroxylation in the ER, [RefSeq, PubMed]; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (PubMed:27119146). Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea (PubMed:28115524). Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly (PubMed:27119146, PubMed:28115524). Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases (PubMed:28115524)., [UniProtKB, PubMed, PubMed]; Study found that all 3 mouse Leprecan genes Lepre1, leprel1 and leprel2 are expressed in the notochord; additionally, they are expressed in dorsal root ganglia, limb buds, branchial arches, and developing kidneys., [RefSeq, PubMed]; This report characterizes expression of the P3H1, P3H2 and P3H3 genes in embryonic and adult mice., [RefSeq, PubMed]; Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88836", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:1902494 catalytic complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0032964 collagen biosynthetic process;GO:0017185 peptidyl-lysine hydroxylation;GO:0032963 collagen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CG70-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640Q5-5", "uniprot_id": [ { "id": "PAN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640Q5", "type": "external" } ], "mass": 95451.0, "length": 887, "protein_name": "PAN2-PAN3 deadenylation complex subunit Pan3", "gene_name": "Pan3", "organism": "Mouse", "refseq_name": "PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1", "refseq_ac": [ { "id": "NP_082567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082567", "type": "external" } ], "gene_names_uniprotkb": "Pan3", "gene_names_refseq": "2700050F09Rik; A430027N15Rik; Pan3", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit Pan3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3", "protein_names_refseq": "PAB-dependent poly(A)-specific ribonuclease subunit 3; PAB1P-dependent poly(A)-specific ribonuclease; PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1; PAN2-PAN3 deadenylation complex subunit Pan3; PAN3 polyA specific ribonuclease subunit homolog; Pabp-dependent poly(A) nuclease 3; Pabp1-dependent poly A-specific ribonuclease subunit Pan3; poly(A)-nuclease deadenylation complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72587); (R-MMU-429947)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17595167;18625844;21183079;30084848;32905781;32929177;34678516;40885482", "class_list": "", "function": "CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression. Erratum:[Lab Invest. 2021 Apr;101(4):534-535. doi: 10.1038/s41374-021-00528-2. PMID: 33483599], [RefSeq, PubMed]; Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway. Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A., [UniProtKB, UniProtKB]; Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD). Its activity is required for efficient P-body formation. May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation., [UniProtKB, UniProtKB]; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins., [UniProtKB, UniProtKB]; The poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H3BKF3;Q3U5F2;Q8CE75;Q9CZM6", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004535 poly(A)-specific ribonuclease activity;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0006605 protein targeting;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q640Q5-5", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08207-1", "uniprot_id": [ { "id": "S10AA_MOUSE", "url": "https://www.uniprot.org/uniprot/P08207", "type": "external" } ], "mass": 11186.0, "length": 97, "protein_name": "Protein S100-A10", "gene_name": "S100a10", "organism": "Mouse", "refseq_name": "protein S100-A10", "refseq_ac": [ { "id": "NP_033138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033138", "type": "external" } ], "gene_names_uniprotkb": "S100a10; Cal1l", "gene_names_refseq": "42C; CAL12; CLP11; Cal1l; S100a10; p10; p11", "protein_names_uniprotkb": "Protein S100-A10; Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; S100 calcium-binding protein A10; p10 protein; p11", "protein_names_refseq": "S100 calcium binding protein A10 (calgizzarin); S100 calcium-binding protein A10; calcium binding protein A11 (calgizzarin); calpactin I light chain; calpactin-1 light chain; cellular ligand of annexin II; protein S100-A10", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:20194); (R-MMU-75205)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "23806337;25428506;28135057;30084848;3038891;31112734;34428180;38232535;38372137", "class_list": "", "function": "Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase., [UniProtKB]; Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10., [RefSeq, PubMed]; S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045121 membrane raft", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0043547 positive regulation of GTPase activity;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0072659 protein localization to plasma membrane;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P08207-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61045-1", "uniprot_id": [ { "id": "SIM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61045", "type": "external" } ], "mass": 85541.0, "length": 765, "protein_name": "Single-minded homolog 1", "gene_name": "Sim1", "organism": "Mouse", "refseq_name": "single-minded homolog 1", "refseq_ac": [ { "id": "NP_035506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035506", "type": "external" } ], "gene_names_uniprotkb": "Sim1", "gene_names_refseq": "Sim1; bHLHe14; mSIM1", "protein_names_uniprotkb": "Single-minded homolog 1; mSIM1", "protein_names_refseq": "single-minded 1; single-minded homolog 1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20464)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;8812055;8927054;9020169;9199934", "class_list": "", "function": "Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70284;P70183", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61045-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBM0-1", "uniprot_id": [ { "id": "ABCG8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBM0", "type": "external" } ], "mass": 75996.0, "length": 673, "protein_name": "ATP-binding cassette sub-family G member 8", "gene_name": "Abcg8", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family G member 8 isoform 2", "refseq_ac": [ { "id": "NP_001272934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272934", "type": "external" } ], "gene_names_uniprotkb": "Abcg8", "gene_names_refseq": "1300003C16Rik; Abcg8; sterolin-2", "protein_names_uniprotkb": "ATP-binding cassette sub-family G member 8; 7.6.2.-; Sterolin-2", "protein_names_refseq": "ATP-binding cassette sub-family G member 8 isoform 2; ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8; sterolin 2", "tax_id": 10090, "disease": "sitosterolemia 1 (Disease Ontology:DOID:0070634); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); sitosterolemia (Disease Ontology:DOID:0090019); familial hyperlipidemia (Disease Ontology:DOID:1168); cholestasis (Disease Ontology:DOID:13580); arteriosclerosis (Disease Ontology:DOID:2349); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:67470); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11099417;11452359;11901146;11907139;12208867;12444248;12777468;14504269;14657202;15040800;15054092;16352607;16867993;18402465;21750661;25378657;25428506;30084848;36839356", "class_list": "", "function": "ABCG5 and ABCG8 Are Involved in Vitamin K Transport. Publication Status: Online-Only, [RefSeq, PubMed]; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:25378657). Plays an important role in preventing the accumulation of dietary plant sterols in the body (PubMed:12444248, PubMed:14657202). Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG5 has ATPase activity (PubMed:16352607, PubMed:16867993)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Alternatively spliced forms for Abcg8 were identified, resulting from a CAG repeat at the intron 1 splice-acceptor site, causing a deletion of a glutamine, [RefSeq, PubMed]; Regulation by liver X receptors alpha and beta, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R543", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex;GO:0016020 membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0055085 transmembrane transport;GO:0010949 negative regulation of intestinal phytosterol absorption;GO:0015914 phospholipid transport;GO:0030299 intestinal cholesterol absorption", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9DBM0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJI0-1", "uniprot_id": [ { "id": "MA7D1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJI0", "type": "external" } ], "mass": 93276.0, "length": 846, "protein_name": "MAP7 domain-containing protein 1", "gene_name": "Map7d1", "organism": "Mouse", "refseq_name": "MAP7 domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_659190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659190", "type": "external" } ], "gene_names_uniprotkb": "Map7d1; Kiaa1187; Mtap7d1", "gene_names_refseq": "Map7d1; Mtap7d1; Parcc1; Rprc1; mKIAA1187", "protein_names_uniprotkb": "MAP7 domain-containing protein 1", "protein_names_refseq": "MAP7 domain-containing protein 1 isoform 1; MAP7 domain-containing protein 1; arginine/proline rich coiled-coil 1; microtubule-associated protein 7 domain containing 1; proline arginine rich coiled coil 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:245877)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "17242355;19144319;21183079;21750661;22645316;26495903;27503845;28135057;28528544;32848054;34428180;35470240;35820727;36288343;40885482", "class_list": "", "function": "Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules., [UniProtKB, PubMed]; Overexpression of a phosphomimetic MAP7D1 mutant in which Ser 315 is substituted with glutamic acid (MAP7D1 S315E), but not wild-type MAP7D1, fully rescues the axon elongation defects in Dclk1 knockdown neurons., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80TI3;Q8CIL3;Q8VCG2;Q91YQ4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "A2AJI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UX83-1", "uniprot_id": [ { "id": "1A1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UX83", "type": "external" } ], "mass": 66129.0, "length": 580, "protein_name": "Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2", "gene_name": "Accsl", "organism": "Mouse", "refseq_name": "probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001028624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028624", "type": "external" } ], "gene_names_uniprotkb": "Accsl; Gm1967", "gene_names_refseq": "Accsl; Gm1967", "protein_names_uniprotkb": "Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; ACC synthase-like protein 2", "protein_names_refseq": "1-aminocyclopropane-1-carboxylate synthase (non-functional)-like; 1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like; 1-aminocyclopropane-1-carboxylate synthase-like protein 2; ACC synthase-like protein 2; novel aminotransferase class I and II domain containing protein; probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1; probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381411)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ30", "ec_number_list": [], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008483 transaminase activity", "go_cellular_component": "", "go_biological_process": "GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UX83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32261-1", "uniprot_id": [ { "id": "ANT3_MOUSE", "url": "https://www.uniprot.org/uniprot/P32261", "type": "external" } ], "mass": 52004.0, "length": 465, "protein_name": "Antithrombin-III", "gene_name": "Serpinc1", "organism": "Mouse", "refseq_name": "antithrombin-III isoform 1 precursor", "refseq_ac": [ { "id": "NP_543120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543120", "type": "external" } ], "gene_names_uniprotkb": "Serpinc1; At3", "gene_names_refseq": "ATIII; At-3; At3; Serpinc1", "protein_names_uniprotkb": "Antithrombin-III; ATIII; Serpin C1", "protein_names_refseq": "anti-thrombin 3; antithrombin-III isoform 1 precursor; antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin C1; serpin peptidase inhibitor, clade C, member 1", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); osteonecrosis (Disease Ontology:DOID:10159); disseminated intravascular coagulation (Disease Ontology:DOID:11247); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); toxic shock syndrome (Disease Ontology:DOID:14115); ovarian cancer (Disease Ontology:DOID:2394); acute kidney failure (Disease Ontology:DOID:3021); antithrombin III deficiency (Disease Ontology:DOID:3755); intermediate coronary syndrome (Disease Ontology:DOID:8805); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11905); (R-MMU-381426); (R-MMU-8957275); (R-MMU-9769733); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1440494;16944957;17330941;21750661;23550037;25428506;30694755;30870413;32152506;34428180;35984892;36288343;37507081;37828378;39627609;40997131", "class_list": "glycogene", "function": "Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis., [RefSeq, PubMed]; Trancriptomic analysis shows that expression of the antithrombins serpin C1 and D1 is significantly reduced in Schwann cell-deficient mice. In the absence of peripheral neuromuscular activity, neurodegeneration is completely blocked, and expression of prothrombin in muscle is markedly reduced. Publication Status: Online-Only, [RefSeq, PubMed]; Tumor size and the number of diethylnitrosamine and carbon tetrachloride-induced liver tumors significantly increased in antithrombin (AT)-insufficient mice compared with the wild-type mice. AT insufficiency led to increased susceptibility to liver tumorigenesis by increasing hepatic inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007584 response to nutrient;GO:0007596 blood coagulation;GO:0030193 regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32261-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78XR0-1", "uniprot_id": [ { "id": "TPC6A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78XR0", "type": "external" } ], "mass": 17430.0, "length": 159, "protein_name": "Trafficking protein particle complex subunit 6A", "gene_name": "Trappc6a", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 6A isoform b", "refseq_ac": [ { "id": "NP_001318110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001318110", "type": "external" } ], "gene_names_uniprotkb": "Trappc6a", "gene_names_refseq": "1810073E21Rik; 4930519D19Rik; TRS33; Trappc6a; mhyp", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 6A; TRAPP complex subunit 6A", "protein_names_refseq": "TRAPP complex subunit 6A; trafficking protein particle complex subunit 6A isoform b; trafficking protein particle complex subunit 6A", "tax_id": 10090, "disease": "neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy (Disease Ontology:DOID:0060934)", "pathway": " (mmu:67091); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16697553;21183079;21750661;34428180", "class_list": "", "function": "May play a role in vesicular transport during the biogenesis of melanosomes., [UniProtKB, PubMed]; The data implicate mammalian TRAPPC6A in vesicle trafficking during melanosome biogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQP0;Q8C2C8;Q9CQ27;Q9D8H6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005801 cis-Golgi network;GO:0005802 trans-Golgi network;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0099022 vesicle tethering;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q78XR0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35600-1", "uniprot_id": [ { "id": "ABCA4_MOUSE", "url": "https://www.uniprot.org/uniprot/O35600", "type": "external" } ], "mass": 260209.0, "length": 2310, "protein_name": "Retinal-specific phospholipid-transporting ATPase ABCA4", "gene_name": "Abca4", "organism": "Mouse", "refseq_name": "retinal-specific phospholipid-transporting ATPase ABCA4", "refseq_ac": [ { "id": "NP_031404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031404", "type": "external" } ], "gene_names_uniprotkb": "Abca4; Abcr", "gene_names_refseq": "Abc10; Abca4; Abcr; D430003I15Rik; RmP", "protein_names_uniprotkb": "Retinal-specific phospholipid-transporting ATPase ABCA4; 7.6.2.1; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; Retinal-specific ATP-binding cassette transporter; RmP", "protein_names_refseq": "ATP-binding cassette 10; ATP-binding cassette, sub-family A (ABC1), member 4; RIM ABC transporter; Rim protein; retinal-specific ATP-binding cassette transporter; retinal-specific phospholipid-transporting ATPase ABCA4", "tax_id": 10090, "disease": "Stargardt disease (Disease Ontology:DOID:0050817); retinitis pigmentosa 91 (Disease Ontology:DOID:0061106); age related macular degeneration 2 (Disease Ontology:DOID:0110015); retinitis pigmentosa 19 (Disease Ontology:DOID:0110354); cone-rod dystrophy 3 (Disease Ontology:DOID:0111013); retinitis pigmentosa (Disease Ontology:DOID:10584); macular degeneration (Disease Ontology:DOID:4448); retinal degeneration (Disease Ontology:DOID:8466); fundus dystrophy (Disease Ontology:DOID:8501)", "pathway": " (mmu:11304); (R-MMU-2453902); (R-MMU-382556)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10412977;10852960;20485683;21750661;22735453;25428506;30899004;9202155", "class_list": "", "function": "Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid (PubMed:10412977, PubMed:10852960, PubMed:22735453). Displays ATPase activity in vitro in absence of retinal substrate (By similarity). May display GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (By similarity). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein was the first of the ABC transporters to be observed in photoreceptors and may play a role in the photoresponse. Mutations in the human gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 9, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0001750 photoreceptor outer segment;GO:0120202 rod photoreceptor disc membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006869 lipid transport;GO:0006649 phospholipid transfer to membrane;GO:0007601 visual perception;GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O35600-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56379-1", "uniprot_id": [ { "id": "ATP68_MOUSE", "url": "https://www.uniprot.org/uniprot/P56379", "type": "external" } ], "mass": 6698.0, "length": 58, "protein_name": "ATP synthase F(0) complex subunit j, mitochondrial", "gene_name": "Atp5mj", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit j, mitochondrial", "refseq_ac": [ { "id": "NP_081636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081636", "type": "external" } ], "gene_names_uniprotkb": "Atp5mj; Atp5mpl; Mp68", "gene_names_refseq": "2010107E04Rik; 9430003J03Rik; Atp5mj; Atp5mpl; MLQ; Mp68", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit j, mitochondrial; 6.8 kDa mitochondrial proteolipid protein; ATP synthase membrane subunit 6.8PL; ATP synthase subunit ATP5MPL, mitochondrial; MLQ", "protein_names_refseq": "6.8 kDa mitochondrial proteolipid protein; ATP synthase F(0) complex subunit j, mitochondrial; ATP synthase membrane subunit 6.8PL; ATP synthase subunit ATP5MJ, mitochondrial; ATP synthase subunit ATP5MPL, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:70257); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;30779550;34428180;35820727;36288343;37507081", "class_list": "", "function": "Subunit j, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain. Minor subunit required to maintain the ATP synthase population in the mitochondria (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0001650 fibrillar center;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56379-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1F6-1", "uniprot_id": [ { "id": "2ABA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1F6", "type": "external" } ], "mass": 51692.0, "length": 447, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "Ppp2r2a", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2", "refseq_ac": [ { "id": "NP_001192117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192117", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r2a", "gene_names_refseq": "2410004D02Rik; B55; Ppp2r2a; mKIAA1541", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; B55; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2", "tax_id": 10090, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:71978); (R-MMU-2995383); (R-MMU-69231); (R-MMU-69273); (R-MMU-975957); (R-MMU-9860927)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "18042541;18432318;21750661;30084848;30611118;31219806;32582689;33300544;34428180;37507081;37828378;38889006;39003739", "class_list": "", "function": "PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:39003739). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (PubMed:39003739). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity)., [UniProtKB, UniProtKB, PubMed]; That B55alpha-dependent targeting of the PP2A holoenzyme to Akt selectively regulates Akt phosphorylation at Thr-308 to regulate cell proliferation and survival., [RefSeq, PubMed]; The PP2A regulatory subunit PPP2R2A controls NAD[+] biosynthesis to regulate T cell subset differentiation in systemic autoimmunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0044877 protein-containing complex binding;GO:0048156 tau protein binding;GO:0051721 protein phosphatase 2A binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0045202 synapse;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0043278 response to morphine;GO:0006470 protein dephosphorylation;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6P1F6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A3V1-1", "uniprot_id": [ { "id": "AK17B_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A3V1", "type": "external" } ], "mass": 111066.0, "length": 959, "protein_name": "A-kinase anchor protein 17B", "gene_name": "Akap17b", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 17B isoform 1", "refseq_ac": [ { "id": "NP_001075425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075425", "type": "external" } ], "gene_names_uniprotkb": "Akap17b; Sfrs17b", "gene_names_refseq": "AKAP-17B; Akap17b; B230333C21Rik; C230056F04Rik; PRKA17B; Sfrs17b; Srsf17b; Talia", "protein_names_uniprotkb": "A-kinase anchor protein 17B; AKAP-17B; PRKA17B; Protein Talia; Protein kinase A-anchoring protein 17B; Splicing factor, arginine/serine-rich 17B", "protein_names_refseq": "A kinase (PRKA) anchor protein 17B; A-kinase anchor protein 17B isoform 1; protein Talia; protein kinase A-anchoring protein 17B; serine/arginine-rich splicing factor 17B; splicing factor, arginine/serine-rich 17b", "tax_id": 10090, "disease": "", "pathway": " (mmu:338351)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;17302988;21183079;21750661", "class_list": "", "function": "Splice factor regulating alternative splice site selection for certain mRNA precursors., [UniProtKB]; The previously undescribed gene Talia is expressed specifically in the distal-most part of the extraembryonic ectoderm, adjacent to the epiblast, and is therefore potential candidates for regulating early patterning events. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZD2;Q0P534;Q8BR01;Q8C6P6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2A3V1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37172-1", "uniprot_id": [ { "id": "ACVR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P37172", "type": "external" } ], "mass": 57226.0, "length": 509, "protein_name": "Activin receptor type-1", "gene_name": "Acvr1", "organism": "Mouse", "refseq_name": "activin receptor type-1 precursor", "refseq_ac": [ { "id": "NP_001103674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103674", "type": "external" } ], "gene_names_uniprotkb": "Acvr1; Acvrlk2; Tgfb1", "gene_names_refseq": "ALK2; ActR-I; ActRIA; Acvr1a; Acvr1; Acvrlk2; Acvr; Alk-2; Alk8; D330013D15Rik; SKR1; Tsk7L", "protein_names_uniprotkb": "Activin receptor type-1; 2.7.11.30; ACTR-I; Activin receptor type I; SKR1; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; TSK-7L; TSR-I", "protein_names_refseq": "TGF-B superfamily receptor type I; TSK-7L; TSR-I; activin receptor type I; activin receptor type-1 precursor; activin receptor type-1; serine/threonine-protein kinase receptor R1", "tax_id": 10090, "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); severe pre-eclampsia (Disease Ontology:DOID:13129); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); exfoliation syndrome (Disease Ontology:DOID:13641); primary angle-closure glaucoma (Disease Ontology:DOID:1405); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:11477)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10479450;11471062;15531373;21750661;21945937;25413979;31219806;31800957;37828378;38557054;8388127", "class_list": "", "function": "BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension., [RefSeq, PubMed]; Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:10479450, PubMed:15531373, PubMed:21945937). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity) (PubMed:10479450, PubMed:15531373, PubMed:21945937, PubMed:25413979). May promote the expression of HAMP, potentially via its interaction with BMP6 (PubMed:31800957)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDH5;Q91VF1", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0048179 activin receptor complex;GO:0070724 BMP receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P37172-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D0G895-1", "uniprot_id": [ { "id": "ACE3_MOUSE", "url": "https://www.uniprot.org/uniprot/D0G895", "type": "external" } ], "mass": 85874.0, "length": 737, "protein_name": "Angiotensin-converting enzyme-like protein Ace3", "gene_name": "Ace3", "organism": "Mouse", "refseq_name": "angiotensin-converting enzyme-like protein Ace3 precursor", "refseq_ac": [ { "id": "NP_001094923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094923", "type": "external" } ], "gene_names_uniprotkb": "Ace3", "gene_names_refseq": "Ace3; EG217246", "protein_names_uniprotkb": "Angiotensin-converting enzyme-like protein Ace3", "protein_names_refseq": "angiotensin I converting enzyme (peptidyl-dipeptidase A) 3; angiotensin-converting enzyme-like protein Ace3 precursor; angiotensin-converting enzyme-like protein Ace3", "tax_id": 10090, "disease": "", "pathway": " (mmu:217246)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17597519;19880118;20421979;25428506;26892527;30059200;35960805", "class_list": "", "function": "ACE3 inhibits pressure overload-induced cardiac hypertrophy by blocking the MEK-ERK1/2 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Identified an IZUMO1-interacting protein in sperm, which was identified as testis specific ACE homologue ACE3. Publication Status: Online-Only, [RefSeq, PubMed]; In the ACE 3/3 animals, atherosclerotic lesion area was not different from wild type controls despite reduced plasma ACE activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0008241 peptidyl-dipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0003084 positive regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "D0G895-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53368-1", "uniprot_id": [ { "id": "8ODP_MOUSE", "url": "https://www.uniprot.org/uniprot/P53368", "type": "external" } ], "mass": 17908.0, "length": 156, "protein_name": "Oxidized purine nucleoside triphosphate hydrolase", "gene_name": "Nudt1", "organism": "Mouse", "refseq_name": "oxidized purine nucleoside triphosphate hydrolase", "refseq_ac": [ { "id": "NP_032663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032663", "type": "external" } ], "gene_names_uniprotkb": "Nudt1; Mth1", "gene_names_refseq": "Mth1; Nudt1", "protein_names_uniprotkb": "Oxidized purine nucleoside triphosphate hydrolase; 2-hydroxy-dATP diphosphatase; 3.6.1.-; 3.6.1.56; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; Methylated purine nucleoside triphosphate hydrolase; Nucleoside diphosphate-linked moiety X motif 1; Nudix motif 1", "protein_names_refseq": "2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-7,8-dihydro-2'-dGTPase; 8-oxo-dGTPase; methylated purine nucleoside triphosphate hydrolase; mutT human homolog (8-oxo-dGTPase); nucleoside diphosphate-linked moiety X motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; nudix motif 1; oxidized purine nucleoside triphosphate hydrolase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:17766); (R-MMU-2393930)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11572992;21750661;29281266;30304478;32144205;35708697;35753523;7592783;9013634", "class_list": "", "function": "NUDT1 promotes the accumulation and longevity of CD103(+) TRM cells in primary biliary cholangitis., [RefSeq, PubMed]; Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97795;Q542J4;Q8VDG0", "ec_number_list": [ { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.56", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0030515 snoRNA binding;GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0047693 ATP diphosphatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042262 DNA protection;GO:0006152 purine nucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53368-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZW4-1", "uniprot_id": [ { "id": "ACSL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZW4", "type": "external" } ], "mass": 80492.0, "length": 720, "protein_name": "Fatty acid CoA ligase Acsl3", "gene_name": "Acsl3", "organism": "Mouse", "refseq_name": "fatty acid CoA ligase Acsl3 isoform a", "refseq_ac": [ { "id": "NP_001028778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028778", "type": "external" } ], "gene_names_uniprotkb": "Acsl3; Acs3; Facl3", "gene_names_refseq": "2610510B12Rik; Acs3; Acsl3; Facl3; LACS 3; Pro2194", "protein_names_uniprotkb": "Fatty acid CoA ligase Acsl3; 6.2.1.15; 6.2.1.2; 6.2.1.3; Arachidonate--CoA ligase; LACS 3; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; Medium-chain acyl-CoA ligase Acsl3", "protein_names_refseq": "arachidonate--CoA ligase; fatty acid CoA ligase Acsl3 isoform a; fatty acid CoA ligase Acsl3; fatty acid Coenzyme A ligase, long chain 3; long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; medium-chain acyl-CoA ligase Acsl3", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:74205); (R-MMU-434313); (R-MMU-75876)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16452087;19737935;21750661;25428506;30084848;31219806;33127675;33713834;34418053;34428180;35820727;36210013;39285846", "class_list": "", "function": "ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting TRIM25-mediated ubiquitination of ACSL3., [RefSeq, PubMed]; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1J7", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042998 positive regulation of Golgi to plasma membrane protein transport;GO:0044539 long-chain fatty acid import into cell", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CZW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26150-1", "uniprot_id": [ { "id": "3BHS3_MOUSE", "url": "https://www.uniprot.org/uniprot/P26150", "type": "external" } ], "mass": 42031.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3", "gene_name": "Hsd3b3", "organism": "Mouse", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1", "refseq_ac": [ { "id": "NP_001155214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155214", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b3", "gene_names_refseq": "9030618K22Rik; Hsd3b3", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type III; 3-beta-HSD III; 3-beta-hydroxy-5-ene steroid dehydrogenase; Delta-5-3-ketosteroid isomerase; Progesterone reductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase 3; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type III; 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type 3; 3-beta-HSD III; 3-beta-hydroxy-5-ene steroid dehydrogenase; delta-5-3-ketosteroid isomerase; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; progesterone reductase; steroid delta-isomerase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (mmu:15494); (R-MMU-193048); (R-MMU-193993); (R-MMU-194002)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1924345;21750661;30084848;37453647;40997131", "class_list": "", "function": "3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" } ], "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006700 C21-steroid hormone biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0008207 C21-steroid hormone metabolic process;GO:0034757 negative regulation of iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P26150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04841-1", "uniprot_id": [ { "id": "3MG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04841", "type": "external" } ], "mass": 36472.0, "length": 333, "protein_name": "DNA-3-methyladenine glycosylase", "gene_name": "Mpg", "organism": "Mouse", "refseq_name": "DNA-3-methyladenine glycosylase", "refseq_ac": [ { "id": "NP_034952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034952", "type": "external" } ], "gene_names_uniprotkb": "Mpg; Mid1", "gene_names_refseq": "9830006D05; APNG; Aag; Mid1; Mpg", "protein_names_uniprotkb": "DNA-3-methyladenine glycosylase; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3.2.2.21; ADPG; N-methylpurine-DNA glycosylase", "protein_names_refseq": "3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3-methyladenine DNA glycosylase; ADPG; DNA-3-methyladenine glycosylase; alkylpurine-DNA-N-glycosylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:268395); (R-MMU-110331); (R-MMU-110357)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;29187734;32042007;7832991;8318735;8435858;8589517", "class_list": "", "function": "Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVE7;Q64182", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.21", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003905 alkylbase DNA N-glycosylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04841-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31387-1", "uniprot_id": [ { "id": "5HT5B_MOUSE", "url": "https://www.uniprot.org/uniprot/P31387", "type": "external" } ], "mass": 41201.0, "length": 370, "protein_name": "5-hydroxytryptamine receptor 5B", "gene_name": "Htr5b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Htr5b; 5ht5b", "gene_names_refseq": "", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 5B; 5-HT-5B; 5-HT5B; Serotonin receptor 5B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:15564)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;8450829", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8450829). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5b is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1RME2", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0001586 Gi/o-coupled serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31387-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35469-1", "uniprot_id": [ { "id": "3BHS6_MOUSE", "url": "https://www.uniprot.org/uniprot/O35469", "type": "external" } ], "mass": 41977.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6", "gene_name": "Hsd3b6", "organism": "Mouse", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6", "refseq_ac": [ { "id": "NP_038849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038849", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b6", "gene_names_refseq": "Hsd3b6", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6; 1.1.1.-; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI; 3-beta-HSD VI; 3-beta-hydroxy-5-ene steroid dehydrogenase; Delta-5-3-ketosteroid isomerase; Progesterone reductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI; 3-beta-HSD VI; 3beta-HSD VI; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 pseudogene; hydroxysteroid dehydrogenase-6, delta<5>-3-beta", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (mmu:15497); (R-MMU-193048); (R-MMU-193993); (R-MMU-194002)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9075693", "class_list": "", "function": "3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. May be involved in local production of progesterone., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQN7", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" } ], "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006700 C21-steroid hormone biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0006705 mineralocorticoid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35469-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88987-1", "uniprot_id": [ { "id": "AKAP3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88987", "type": "external" } ], "mass": 95556.0, "length": 864, "protein_name": "A-kinase anchor protein 3", "gene_name": "Akap3", "organism": "Mouse", "refseq_name": "A-kinase anchor protein 3", "refseq_ac": [ { "id": "NP_033780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033780", "type": "external" } ], "gene_names_uniprotkb": "Akap3; Akap110", "gene_names_refseq": "Akap3; Prka3", "protein_names_uniprotkb": "A-kinase anchor protein 3; A-kinase anchor protein 110 kDa; AKAP 110; AKAP-3; PRKA3; Protein kinase A-anchoring protein 3", "protein_names_refseq": "A kinase (PRKA) anchor protein 3; A-kinase anchor protein 110 kDa; A-kinase anchor protein 3; AKAP 110; AKAP-3; Protein kinase A-anchoring protein 3", "tax_id": 10090, "disease": "spermatogenic failure 82 (Disease Ontology:DOID:0070581)", "pathway": " (mmu:11642)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10319321;11278869;31599954;31969357;36267566;37146716;37458246;38145487", "class_list": "", "function": "AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertilitydagger., [RefSeq, PubMed]; MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of sperm fibrous sheath (PubMed:31969357). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:31969357)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497M9", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0045184 establishment of protein localization;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0008104 intracellular protein localization;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88987-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13011-1", "uniprot_id": [ { "id": "SCD2_MOUSE", "url": "https://www.uniprot.org/uniprot/P13011", "type": "external" } ], "mass": 40916.0, "length": 358, "protein_name": "Stearoyl-CoA desaturase 2", "gene_name": "Scd2", "organism": "Mouse", "refseq_name": "stearoyl-CoA desaturase 2", "refseq_ac": [ { "id": "NP_033154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033154", "type": "external" } ], "gene_names_uniprotkb": "Scd2", "gene_names_refseq": "Mir5114; Scd-2; Scd2; mir-5114; swty", "protein_names_uniprotkb": "Stearoyl-CoA desaturase 2; 1.14.19.1; Acyl-CoA desaturase 2; Delta(9)-desaturase 2; Delta-9 desaturase 2; Fatty acid desaturase 2", "protein_names_refseq": "Acyl-CoA desaturase 2 (Stearoyl-CoA desaturase 2) (Fatty acid desaturase 2) (Delta(9)-desaturase 2); delta(9)-desaturase 2; fatty acid desaturase 2; stearoyl-CoA desaturase 2", "tax_id": 10090, "disease": "restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (mmu:20250)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10545940;11161812;12815040;16118274;16443825;21750661;22872234;25428506;2570068;30084848;30779550;34188173;34203471;34428180;35820727;37156770;37417745", "class_list": "glycogene", "function": "Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - beta-catenin cascade to promote liver tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages., [RefSeq, PubMed]; SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4(+) T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:16443825). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:16443825). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:16443825). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates (PubMed:16118274). Important for normal permeability barrier function of the skin in neonates (PubMed:16118274)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH96", "ec_number_list": [ { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "1.14.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016491 oxidoreductase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006636 unsaturated fatty acid biosynthetic process;GO:1903966 monounsaturated fatty acid biosynthetic process;GO:0070542 response to fatty acid;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P13011-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23979-1", "uniprot_id": [ { "id": "5HT3A_MOUSE", "url": "https://www.uniprot.org/uniprot/P23979", "type": "external" } ], "mass": 56225.0, "length": 489, "protein_name": "5-hydroxytryptamine receptor 3A", "gene_name": "Htr3a", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 3A isoform 1 precursor", "refseq_ac": [ { "id": "NP_038589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038589", "type": "external" } ], "gene_names_uniprotkb": "Htr3a; 5ht3; Htr3", "gene_names_refseq": "5-HT3A; 5-HT3R; 5-HT3; Htr3a", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3A; 5-HT-3; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine receptor 3; Serotonin receptor 3A; Serotonin-gated ion channel receptor", "protein_names_refseq": "5-hydroxytryptamine receptor 3A isoform 1 precursor; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; serotonin receptor 3A; serotonin-gated ion channel receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); irritable bowel syndrome (Disease Ontology:DOID:9778); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:15561); (R-MMU-112314)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15264219;1718042;25119048;25428506;7683998;7854052;8112471", "class_list": "", "function": "Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QLC0;Q61225;Q61226", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022850 serotonin-gated monoatomic cation channel activity;GO:0042802 identical protein binding;GO:0051378 serotonin binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0007210 serotonin receptor signaling pathway;GO:0032414 positive regulation of ion transmembrane transporter activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23979-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26149-1", "uniprot_id": [ { "id": "3BHS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P26149", "type": "external" } ], "mass": 41923.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2", "gene_name": "Hsd3b2", "organism": "Mouse", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2", "refseq_ac": [ { "id": "NP_694873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694873", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b2", "gene_names_refseq": "3-beta-HSD II; Hsd3b2", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; Delta-5-3-ketosteroid isomerase; Progesterone reductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; hydroxysteroid dehydrogenase-2, delta<5>-3-beta", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (mmu:15493); (R-MMU-193048); (R-MMU-193993); (R-MMU-194002)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1924345;23485106;34428180", "class_list": "", "function": "3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids., [UniProtKB, UniProtKB]; Molecular chaperone-assisted folding of 3-beta hydroxysteroid dehydrogenase-2 is a physiological requirement, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ARN7;Q8R0J6", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" } ], "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006700 C21-steroid hormone biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0008207 C21-steroid hormone metabolic process;GO:0034757 negative regulation of iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26149-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28334-1", "uniprot_id": [ { "id": "5HT1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P28334", "type": "external" } ], "mass": 43079.0, "length": 386, "protein_name": "5-hydroxytryptamine receptor 1B", "gene_name": "Htr1b", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 1B", "refseq_ac": [ { "id": "NP_034612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034612", "type": "external" } ], "gene_names_uniprotkb": "Htr1b; 5ht1b", "gene_names_refseq": "5-HT-1B; Htr1b", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; Serotonin receptor 1B", "protein_names_refseq": "5-HT1B receptor; 5-HT<1B> receptor; 5-hydroxytryptamine receptor 1B; serotonin receptor 1B", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); hypertension (Disease Ontology:DOID:10763); antisocial personality disorder (Disease Ontology:DOID:10939); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); substance abuse (Disease Ontology:DOID:302); ischemia (Disease Ontology:DOID:326); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15551); (R-MMU-390666); (R-MMU-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10651141;1557407;16750486;17325130;36584680;8091214;8742487;9349547", "class_list": "", "function": "Brainstem serotonin neurons selectively gate retinal information flow to thalamus., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1557407, PubMed:17325130). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:1557407, PubMed:17325130). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed:10651141, PubMed:16750486, PubMed:8091214, PubMed:8742487, PubMed:9349547). Besides, plays a role in vasoconstriction of cerebral arteries (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0045471 response to ethanol;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0014059 regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28334-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30966-1", "uniprot_id": [ { "id": "5HT5A_MOUSE", "url": "https://www.uniprot.org/uniprot/P30966", "type": "external" } ], "mass": 40736.0, "length": 357, "protein_name": "5-hydroxytryptamine receptor 5A", "gene_name": "Htr5a", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 5A isoform 1", "refseq_ac": [ { "id": "NP_032340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032340", "type": "external" } ], "gene_names_uniprotkb": "Htr5a; 5ht5a", "gene_names_refseq": "Htr5a; Htr5", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 5A; 5-HT-5A; 5-HT-5; 5-HT5A; Serotonin receptor 5A", "protein_names_refseq": "5-HT-5A; 5-HT5A; 5-hydroxytryptamine receptor 5A isoform 1; 5-hydroxytryptamine receptor 5A; serotonin receptor 5A", "tax_id": 10090, "disease": "intracranial hypertension (Disease Ontology:DOID:9428)", "pathway": " (mmu:15563); (R-MMU-390666); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10197537;1464308;22539842;30084848;30097291;34428180;8450829", "class_list": "", "function": "Cortisol up-regulated the expression and function of two serotonin (S) receptors, HTR2c and HTR5a., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8450829). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5a is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity)., [UniProtKB, UniProtKB, PubMed]; This study demonistrated that loss of htr5A gene strongly upregulates 5-HT1A receptor-mediated currents in the prefrontal cortex., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3URB0", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0001586 Gi/o-coupled serotonin receptor activity;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0021766 hippocampus development;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30966-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32211-1", "uniprot_id": [ { "id": "ACM4_MOUSE", "url": "https://www.uniprot.org/uniprot/P32211", "type": "external" } ], "mass": 52973.0, "length": 479, "protein_name": "Muscarinic acetylcholine receptor M4", "gene_name": "Chrm4", "organism": "Mouse", "refseq_name": "muscarinic acetylcholine receptor M4", "refseq_ac": [ { "id": "NP_031725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031725", "type": "external" } ], "gene_names_uniprotkb": "Chrm4; Chrm-4", "gene_names_refseq": "AChR M4; Chrm-4; Chrm4; M4; mm4 mAChR", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M4; Mm4 mAChR", "protein_names_refseq": "muscarinic acetylcholine receptor 4; muscarinic acetylcholine receptor M4", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:12672); (R-MMU-390648); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;22645316;32848054;37172825;7874308;7916637", "class_list": "", "function": "The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase., [UniProtKB]; Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q64056", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32211-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35374-1", "uniprot_id": [ { "id": "AGTR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P35374", "type": "external" } ], "mass": 41374.0, "length": 363, "protein_name": "Type-2 angiotensin II receptor", "gene_name": "Agtr2", "organism": "Mouse", "refseq_name": "type-2 angiotensin II receptor", "refseq_ac": [ { "id": "NP_031455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031455", "type": "external" } ], "gene_names_uniprotkb": "Agtr2", "gene_names_refseq": "Agtr2", "protein_names_uniprotkb": "Type-2 angiotensin II receptor; AT2 receptor; Angiotensin II type-2 receptor", "protein_names_refseq": "AT2 receptor; angiotensin II type-2 receptor; type-2 angiotensin II receptor", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); stroke (Disease Ontology:DOID:0051061); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); meconium aspiration syndrome (Disease Ontology:DOID:11049); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vesicoureteral reflux (Disease Ontology:DOID:9620); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:11609); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11444984;15539617;38081369;7650042;8267573;8292631;8726696", "class_list": "", "function": "Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8726696). Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways (By similarity). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15539617)., [UniProtKB, PubMed, PubMed, UniProtKB]; Unlocking the protective potential of the angiotensin type 2 receptor (AT2R) in acute lung injury and age-related pulmonary dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35374-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61222-1", "uniprot_id": [ { "id": "ABCE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61222", "type": "external" } ], "mass": 67314.0, "length": 599, "protein_name": "ATP-binding cassette sub-family E member 1", "gene_name": "Abce1", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family E member 1", "refseq_ac": [ { "id": "NP_056566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056566", "type": "external" } ], "gene_names_uniprotkb": "Abce1; Rli", "gene_names_refseq": "Abce1; Oabp; RLI; RNS41; RNS4I; Rnaseli", "protein_names_uniprotkb": "ATP-binding cassette sub-family E member 1; 3.6.5.-; RNS4I; RNase L inhibitor; Ribonuclease 4 inhibitor", "protein_names_refseq": "ATP-binding cassette sub-family E member 1; ATP-binding cassette, sub-family E (OABP), member 1; ATP-binding cassette, subfamily E, member 1; RNS4l (Eye); RNase L inhibitor; ribonuclease 4 inhibitor; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor", "tax_id": 10090, "disease": "breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:24015); (R-MMU-8983711); (R-MMU-909733); (R-MMU-9954714)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10866653;18585418;22872234;24788674;28380459;28528544;29187734;31219806;34203471;34428180;34887587;36210013;37453647;37828378;9524254", "class_list": "", "function": "Expression of RNase L is a signal generated by NMDA receptor in cortical neurons. RNase L expression and RNA degradation may be events that cause neuronal damage induced by NMDA receptor activation., [RefSeq, PubMed]; Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (By similarity). Able to hydrolyze ATP, GTP, UTP and CTP (By similarity). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (By similarity). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (By similarity). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (By similarity). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (By similarity). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:10866653). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]; Our study pinpoints that Abce1 plays an important role in meiosis resumption, spindle integrity and chromosome alignment in meiotic oocytes, [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88793;Q13181;Q13864;Q96AL0;Q96B10;Q99K66", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005506 iron ion binding;GO:0005524 ATP binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006415 translational termination;GO:0006417 regulation of translation;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P61222-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70170-1", "uniprot_id": [ { "id": "ABCC9_MOUSE", "url": "https://www.uniprot.org/uniprot/P70170", "type": "external" } ], "mass": 174239.0, "length": 1546, "protein_name": "ATP-binding cassette sub-family C member 9", "gene_name": "Abcc9", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 9 isoform d", "refseq_ac": [ { "id": "NP_001038185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038185", "type": "external" } ], "gene_names_uniprotkb": "Abcc9; Sur2", "gene_names_refseq": "Abcc9; SUR2A; SUR2B; Sur2", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 9; Sulfonylurea receptor 2", "protein_names_refseq": "ATP-binding cassette sub-family C member 9 isoform d; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; sulfonylurea receptor 2; sulfonylurea-binding protein 2", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); intellectual disability and myopathy syndrome (Disease Ontology:DOID:0070600); Parkinsonism (Disease Ontology:DOID:0080855); dilated cardiomyopathy 1O (Disease Ontology:DOID:0110451); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:20928); (R-MMU-1296025); (R-MMU-382556); (R-MMU-5578775)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21750661;30084848;34428180;37507081;8798681;8826984;9130167", "class_list": "", "function": "Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (PubMed:9130167)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08902;O08920;P70171", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0015459 potassium channel regulator activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0030017 sarcomere", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0072359 circulatory system development;GO:1903409 reactive oxygen species biosynthetic process;GO:0086003 cardiac muscle cell contraction;GO:1904880 response to hydrogen sulfide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70170-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32MW3-1", "uniprot_id": [ { "id": "ACO10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32MW3", "type": "external" } ], "mass": 50552.0, "length": 439, "protein_name": "Acyl-coenzyme A thioesterase 10, mitochondrial", "gene_name": "Acot10", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 10, mitochondrial precursor", "refseq_ac": [ { "id": "NP_073727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073727", "type": "external" } ], "gene_names_uniprotkb": "Acot10", "gene_names_refseq": "Acate3; Acot10; MT-ACT48; p48", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 10, mitochondrial; 3.1.2.-; Acyl-CoA thioesterase 10; Mitochondrial 48 kDa acyl-CoA thioester hydrolase 2; Mt-ACT48.2", "protein_names_refseq": "acyl-Coenzyme A thioesterase 3, mitochondrial; acyl-coenzyme A thioesterase 10, mitochondrial precursor; acyl-coenzyme A thioesterase 10, mitochondrial; mitochondrial 48 kDa acyl-CoA thioester hydrolase 2; mt-ACT48.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:64833)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10383425;17305828", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Active on long chain acyl-CoAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0FJF7;Q32MW2", "ec_number_list": [], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32MW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32Q92-1", "uniprot_id": [ { "id": "ACOT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32Q92", "type": "external" } ], "mass": 46769.0, "length": 419, "protein_name": "Acyl-coenzyme A thioesterase 6", "gene_name": "Acot6", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 6 isoform 1", "refseq_ac": [ { "id": "NP_766168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766168", "type": "external" } ], "gene_names_uniprotkb": "Acot6", "gene_names_refseq": "4632408A20Rik; A330054B07; Acot6", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 6; 3.1.2.-; Acyl-CoA thioesterase 6", "protein_names_refseq": "acyl-coenzyme A thioesterase 6 isoform 1; acyl-coenzyme A thioesterase 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:217700)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17613526", "class_list": "", "function": "Acot6 was identified as a target gene of the peroxisome proliferator-activated receptor alpha (PPARalpha) and is up-regulated in mouse liver in a PPARalpha-dependent manner., [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQG7;Q8BXE0;Q8BYI3;Q99LZ0", "ec_number_list": [ { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32Q92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3THG9-1", "uniprot_id": [ { "id": "AASD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3THG9", "type": "external" } ], "mass": 44971.0, "length": 412, "protein_name": "Alanyl-tRNA editing protein Aarsd1", "gene_name": "Aarsd1", "organism": "Mouse", "refseq_name": "alanyl-tRNA editing protein Aarsd1", "refseq_ac": [ { "id": "NP_659078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659078", "type": "external" } ], "gene_names_uniprotkb": "Aarsd1; Alax", "gene_names_refseq": "1110069E20Rik; 2310044P18Rik; Aarsd1; AlaXp-II; AlaX", "protein_names_uniprotkb": "Alanyl-tRNA editing protein Aarsd1; AlaXp-II; AlaX; Alanyl-tRNA deacylase alaX; Alanyl-tRNA synthetase domain-containing protein 1", "protein_names_refseq": "alanyl-tRNA deacylase alaX; alanyl-tRNA editing protein Aarsd1; alanyl-tRNA synthetase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69684)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;18172502;26740625;26884463;31219806;34428180", "class_list": "", "function": "Artificially maintaining Hsp90alpha or knocking down Aarsd1L expression interferes with the differentiation of C2C12 myotubes. Publication Status: Online-Only, [RefSeq, PubMed]; Deacylates mischarged tRNA(Ala) (AlaXp activity), [RefSeq, PubMed]; Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWH8;Q8BVJ6;Q99JS9", "ec_number_list": [], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0002196 Ser-tRNA(Ala) deacylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006419 alanyl-tRNA aminoacylation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3THG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSE9-1", "uniprot_id": [ { "id": "ABCAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSE9", "type": "external" } ], "mass": 568897.0, "length": 5034, "protein_name": "ATP-binding cassette sub-family A member 13", "gene_name": "Abca13", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family A member 13", "refseq_ac": [ { "id": "NP_839990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839990", "type": "external" } ], "gene_names_uniprotkb": "Abca13", "gene_names_refseq": "9830132L24; A930002G16Rik; Abca13", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 13; 7.6.2.-", "protein_names_refseq": "ATP-binding cassette sub-family A member 13; ATP-binding cassette transporter; ATP-binding cassette, sub-family A (ABC1), member 13", "tax_id": 10090, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (mmu:268379); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12697998;12706902;21750661;23221702;25428506;30084848;33478937;35820727", "class_list": "", "function": "ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking., [RefSeq, PubMed]; May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons., [UniProtKB, PubMed]; T4031A replacement affects the function of ABCA13 in the brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80T20;Q8BHZ2;Q8CB91", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006869 lipid transport;GO:0035627 ceramide transport;GO:0032376 positive regulation of cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5SSE9-1", "record_type": "protein", "filter_code": "0000000.1100111.000100.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60614-1", "uniprot_id": [ { "id": "AA2BR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60614", "type": "external" } ], "mass": 36120.0, "length": 332, "protein_name": "Adenosine receptor A2b", "gene_name": "Adora2b", "organism": "Mouse", "refseq_name": "adenosine receptor A2b", "refseq_ac": [ { "id": "NP_031439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031439", "type": "external" } ], "gene_names_uniprotkb": "Adora2b", "gene_names_refseq": "A2BAR; A2BR; A2b; AA2BR; ARA2B; Adora2b", "protein_names_uniprotkb": "Adenosine receptor A2b", "protein_names_refseq": "A2b, Rs; adenosine receptor A2b", "tax_id": 10090, "disease": "", "pathway": " (mmu:11541); (R-MMU-417973); (R-MMU-418555); (R-MMU-5683826)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "31219806;37288658;38174997;38460363;8157966", "class_list": "", "function": "ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis., [RefSeq, PubMed]; Adenosine A2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia., [RefSeq, PubMed]; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB]; Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXI2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001609 G protein-coupled adenosine receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0010701 positive regulation of norepinephrine secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60614-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60813-1", "uniprot_id": [ { "id": "ADM1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60813", "type": "external" } ], "mass": 87490.0, "length": 791, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 1a", "gene_name": "Adam1a", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 1a precursor", "refseq_ac": [ { "id": "NP_742124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742124", "type": "external" } ], "gene_names_uniprotkb": "Adam1a; Adam1; Ftna", "gene_names_refseq": "Adam1a; Adam1; Ftna", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 1a; 3.4.24.-; ADAM 1a; Fertilin subunit alpha-a", "protein_names_refseq": "ADAM 1a; PH-30 alpha; a disintegrin and metalloproteinase domain 1a (fertilin alpha); disintegrin and metalloproteinase domain-containing protein 1a precursor; disintegrin and metalloproteinase domain-containing protein 1a; fertilin alpha; fertilin subunit alpha-a", "tax_id": 10090, "disease": "", "pathway": " (mmu:280668)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12095680;12711316;15194697;7750654;8146185", "class_list": "", "function": "ADAM1a/ADAM2 Fertilin complex has roles in expression of ADAM3 on the cell surface of mouse sperm, [RefSeq, PubMed]; Localization of ADAM1a in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm., [RefSeq, PubMed]; May be involved in sperm-egg fusion., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q60617;Q80WR7;Q8R533", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:1990913 sperm head plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007339 binding of sperm to zona pellucida;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60813-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61102-1", "uniprot_id": [ { "id": "ABCB7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61102", "type": "external" } ], "mass": 82581.0, "length": 752, "protein_name": "Iron-sulfur clusters transporter ABCB7, mitochondrial", "gene_name": "Abcb7", "organism": "Mouse", "refseq_name": "iron-sulfur clusters transporter ABCB7, mitochondrial", "refseq_ac": [ { "id": "NP_033722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033722", "type": "external" } ], "gene_names_uniprotkb": "Abcb7; Abc7", "gene_names_refseq": "Abc7; Abcb7", "protein_names_uniprotkb": "Iron-sulfur clusters transporter ABCB7, mitochondrial; ABC transporter 7 protein; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7", "protein_names_refseq": "ABC transporter 7 protein; ATP-binding cassette 7; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; iron-sulfur clusters transporter ABCB7, mitochondrial", "tax_id": 10090, "disease": "X-linked sideroblastic anemia with ataxia (Disease Ontology:DOID:0050554); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (mmu:11306); (R-MMU-1369007)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12480705;16424901;16467350;17192398;22872234;23576753;25428506;30084848;30765471;31219806;31599954;33300544;34428180;35820727;9143506", "class_list": "", "function": "ABC7 positively regulates the expression of extramitochondrial thioredoxin & that of an intramitochondrial iron-sulfur-containing protein, ferrochelatase. ABC7 contributes to the production of heme during the differentiation of erythroid cells., [RefSeq, PubMed]; Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:16424901, PubMed:16467350). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (PubMed:17192398)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC46;Q3U7S8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0034755 iron ion transmembrane transport;GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q61102-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61151-1", "uniprot_id": [ { "id": "2A5E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61151", "type": "external" } ], "mass": 54713.0, "length": 467, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "gene_name": "Ppp2r5e", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "refseq_ac": [ { "id": "NP_036154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036154", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r5e; Kiaa4006", "gene_names_refseq": "4633401M22Rik; B56beta; Ppp2r5e", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; PP2A B subunit isoform B'-epsilon; PP2A B subunit isoform B56-epsilon; PP2A B subunit isoform PR61-epsilon; PP2A B subunit isoform R5-epsilon", "protein_names_refseq": "protein phosphatase 2A subunit beta; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:26932); (R-MMU-141430); (R-MMU-141444); (R-MMU-195253); (R-MMU-196299); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6811558); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 17, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;34203471;8887688", "class_list": "", "function": "The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with cyclin G in vitro., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1I5;Q571M6;Q8C2M2", "ec_number_list": [], "go_molecular_function": "GO:0072542 protein phosphatase activator activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61151-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64264-1", "uniprot_id": [ { "id": "5HT1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64264", "type": "external" } ], "mass": 46176.0, "length": 421, "protein_name": "5-hydroxytryptamine receptor 1A", "gene_name": "Htr1a", "organism": "Mouse", "refseq_name": "5-hydroxytryptamine receptor 1A", "refseq_ac": [ { "id": "NP_032334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032334", "type": "external" } ], "gene_names_uniprotkb": "Htr1a; Gpcr18", "gene_names_refseq": "Gpcr18; Htr1a", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A", "protein_names_refseq": "5-HT-1A; 5-HT1A receptor; 5-hydroxytryptamine receptor 1A; G-protein coupled receptor 18; serotonin receptor 1A", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652); generalized anxiety disorder (Disease Ontology:DOID:14320); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); substance abuse (Disease Ontology:DOID:302); panic disorder (Disease Ontology:DOID:594); cocaine abuse (Disease Ontology:DOID:809); subacute delirium (Disease Ontology:DOID:8645)", "pathway": " (mmu:15550); (R-MMU-390666)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11080193;17543467;18599790;21508226;38906512;39085354;8254366;8288218;8626793;9826725", "class_list": "", "function": "Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). Also functions as a receptor for various drugs and psychoactive substances (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q60956;Q61617;Q8BGS4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0031117 positive regulation of microtubule depolymerization;GO:0007186 G protein-coupled receptor signaling pathway;GO:0046883 regulation of hormone secretion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007214 gamma-aminobutyric acid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64264-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q2Z6-1", "uniprot_id": [ { "id": "ACOT5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6", "type": "external" } ], "mass": 46573.0, "length": 421, "protein_name": "Acyl-coenzyme A thioesterase 5", "gene_name": "Acot5", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase 5 isoform 1", "refseq_ac": [ { "id": "NP_663419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663419", "type": "external" } ], "gene_names_uniprotkb": "Acot5", "gene_names_refseq": "Acot5; PTE-Ic", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 5; 3.1.2.2; Acyl-CoA thioesterase 5; PTE-Ic; Peroxisomal acyl-CoA thioesterase Ic; Peroxisomal acyl-coenzyme A thioester hydrolase Ic", "protein_names_refseq": "acyl-coenzyme A thioesterase 5 isoform 1; acyl-coenzyme A thioesterase 5; peroxisomal acyl-CoA thioesterase Ic; peroxisomal acyl-coenzyme A thioester hydrolase Ic", "tax_id": 10090, "disease": "", "pathway": " (mmu:217698); (R-MMU-77289); (R-MMU-9033241); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15007068;16940157", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157). Mainly active on medium-chain acyl-CoAs (PubMed:15007068). Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels (PubMed:15007068). May have a function in termination of beta-oxidation of fatty acids (PubMed:15007068)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKJ5", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": 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"GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0032788 saturated monocarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6Q2Z6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78JT3-1", "uniprot_id": [ { "id": "3HAO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78JT3", "type": "external" } ], "mass": 32804.0, "length": 286, "protein_name": "3-hydroxyanthranilate 3,4-dioxygenase", "gene_name": "Haao", "organism": "Mouse", "refseq_name": "3-hydroxyanthranilate 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"0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQI7-1", "uniprot_id": [ { "id": "ABTB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQI7", "type": "external" } ], "mass": 113503.0, "length": 1024, "protein_name": "Ankyrin repeat and BTB/POZ domain-containing protein 2", "gene_name": "Abtb2", "organism": "Mouse", "refseq_name": "ankyrin repeat and BTB/POZ domain-containing protein 2", "refseq_ac": [ { "id": "NP_849221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849221", "type": "external" } ], "gene_names_uniprotkb": "Abtb2", "gene_names_refseq": "Abtb2", "protein_names_uniprotkb": "Ankyrin repeat and BTB/POZ domain-containing protein 2", "protein_names_refseq": "ankyrin repeat and BTB (POZ) domain containing 2; ankyrin repeat and BTB/POZ domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:99382)", "pathway_count": 1, "publication_count": 5, "publication_id_list": 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"reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0097237 cellular response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TQI7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VV3-1", "uniprot_id": [ { "id": "4EBP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VV3", "type": "external" } ], "mass": 11019.0, "length": 101, "protein_name": "Eukaryotic translation initiation factor 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In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; There are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TA53", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXF8-1", "uniprot_id": [ { "id": "ACTT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXF8", "type": "external" } ], "mass": 40443.0, "length": 369, "protein_name": "Actin-related protein T3", "gene_name": "Actrt3", "organism": "Mouse", "refseq_name": "actin-related protein T3", "refseq_ac": [ { "id": "NP_083966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083966", "type": "external" } ], "gene_names_uniprotkb": "Actrt3; Arpm1", "gene_names_refseq": "1700119I24Rik; ARP-T3; Actrt3; Arpm1", "protein_names_uniprotkb": "Actin-related protein T3; ARP-T3; Actin-related protein M1", "protein_names_refseq": "actin related protein M1; actin-related protein M1 homolog; actin-related protein T3", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:76652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18692047", "class_list": "", "function": "These findings suggest that the testis-specific profilin III-ArpM1 complex may be involved in conformational changes in the organization of the sperm-specific nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNH6;Q9D9A6", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0001673 male germ cell nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BXF8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYZ1-1", "uniprot_id": [ { "id": "ABI3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYZ1", "type": "external" } ], "mass": 39107.0, "length": 367, "protein_name": "ABI gene family member 3", "gene_name": "Abi3", "organism": "Mouse", "refseq_name": "ABI gene family member 3 isoform 2", "refseq_ac": [ { "id": "NP_001156936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156936", "type": "external" } ], "gene_names_uniprotkb": "Abi3; Nesh", "gene_names_refseq": "2210414K06Rik; Abi3; NESH", "protein_names_uniprotkb": "ABI gene family member 3; Nesh; New molecule including SH3", "protein_names_refseq": "ABI gene family member 3 isoform 2; ABI gene family, member 3; new molecule including SH3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66610)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11956071;18250455;21183079;21750661;30084848;30779550;34428180;36140776;36895556;38062164", "class_list": "", "function": "Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer's Disease Genetics and Neuropathology. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits ectopic tumor cell metastasis of SRD cells. In vitro, reduces cell motility., [UniProtKB, PubMed]; The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies. Publication Status: Online-Only, [RefSeq, PubMed]; Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA46;Q6PE63;Q9D7S4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030027 lamellipodium;GO:0043197 dendritic spine", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0001764 neuron migration;GO:0030036 actin cytoskeleton organization;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BYZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2H4-1", "uniprot_id": [ { "id": "ACAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2H4", "type": "external" } ], "mass": 81704.0, "length": 740, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "gene_name": "Acap1", "organism": "Mouse", "refseq_name": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "refseq_ac": [ { "id": "NP_722483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722483", "type": "external" } ], "gene_names_uniprotkb": "Acap1; Centb1; Kiaa0050", "gene_names_refseq": "Acap1; Centb1", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1", "protein_names_refseq": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; centaurin, beta 1; cnt-b1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:216859)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17664335;19224205;20173027;25605945;31219806;34428180;35820727", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U441;Q571H6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K2H4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K440-1", "uniprot_id": [ { "id": "ABC8B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K440", "type": "external" } ], "mass": 183039.0, "length": 1620, "protein_name": "ABC-type organic anion transporter ABCA8B", "gene_name": "Abca8b", "organism": "Mouse", "refseq_name": "ABC-type organic anion transporter ABCA8B isoform 1", "refseq_ac": [ { "id": "NP_038879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879", "type": "external" } ], "gene_names_uniprotkb": "Abca8b; Abca8; Kiaa0822", "gene_names_refseq": "Abca8b; Abca8", "protein_names_uniprotkb": "ABC-type organic anion transporter ABCA8B; 7.6.2.-; ATP-binding cassette sub-family A member 8B", "protein_names_refseq": "ABC-type organic anion transporter ABCA8B isoform 1; ABC-type organic anion transporter ABCA8B; ATP-binding cassette sub-family A member 8-B; ATP-binding cassette, sub-family A (ABC1), member 8b", "tax_id": 10090, "disease": "", "pathway": " (mmu:27404); (R-MMU-382556)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10708515;12532264;16445568;28882873;29300488;34428180;35820727", "class_list": "", "function": "ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels., [RefSeq, PubMed]; Mediates cholesterol and taurocholate efflux (PubMed:28882873). Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (By similarity)., [UniProtKB, UniProtKB, PubMed]; Study results suggest that mABCA8b/ABCA8 functions as a sinusoidal efflux transporter for at least cholesterol and taurocholate in mouse and human liver., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AM55;Q69ZY4;Q8BRQ1;Q9JL38", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006869 lipid transport;GO:0010875 positive regulation of cholesterol efflux;GO:0033344 cholesterol efflux;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K440-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K441-1", "uniprot_id": [ { "id": "ABCA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K441", "type": "external" } ], "mass": 183283.0, "length": 1624, "protein_name": "ATP-binding cassette sub-family A member 6", "gene_name": "Abca6", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family A member 6 isoform 2", "refseq_ac": [ { "id": "NP_001160028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160028", "type": "external" } ], "gene_names_uniprotkb": "Abca6", "gene_names_refseq": "6330565N06Rik; Abca6", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 6; 7.6.2.-", "protein_names_refseq": "ATP-binding cassette sub-family A member 6 isoform 2; ATP-binding cassette transporter sub-family A member 6; ATP-binding cassette, sub-family A (ABC1), member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:76184); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12532264;25428506;30084848;34203471;34428180", "class_list": "", "function": "Probable transporter which may play a role in macrophage lipid transport and homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A6R3;Q8BGH0;Q8BPT1", "ec_number_list": [ { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K441-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K449-1", "uniprot_id": [ { "id": "ABCA9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K449", "type": "external" } ], "mass": 183114.0, "length": 1623, "protein_name": "ATP-binding cassette sub-family A member 9", "gene_name": "Abca9", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family A member 9", "refseq_ac": [ { "id": "NP_671753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671753", "type": "external" } ], "gene_names_uniprotkb": "Abca9", "gene_names_refseq": "Abca9; D630040K07Rik", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 9; 7.6.2.-", "protein_names_refseq": "ATP-binding cassette sub-family A member 9; ATP-binding cassette transporter sub-family A member 9; ATP-binding cassette, sub-family A (ABC1), member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:217262); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12532264;16445568;25428506;29520568;31219806;34428180", "class_list": "", "function": "Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A6R5;Q8C114", "ec_number_list": [ { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K449-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R420-1", "uniprot_id": [ { "id": "ABCA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R420", "type": "external" } ], "mass": 191971.0, "length": 1704, "protein_name": "Phospholipid-transporting ATPase ABCA3", "gene_name": "Abca3", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase ABCA3", "refseq_ac": [ { "id": "NP_001034670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034670", "type": "external" } ], "gene_names_uniprotkb": "Abca3", "gene_names_refseq": "1810036E22Rik; ABC-C; Abc3; Abca3", "protein_names_uniprotkb": "Phospholipid-transporting ATPase ABCA3; 7.6.2.1; 7.6.2.2; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3", "protein_names_refseq": "ATP-binding cassette, sub-family A (ABC1), member 3; phospholipid-transporting ATPase ABCA3; xenobiotic-transporting ATPase ABCA3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neonatal respiratory failure (Disease Ontology:DOID:11161); respiratory failure (Disease Ontology:DOID:11162); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); interstitial lung disease (Disease Ontology:DOID:3082); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:27410); (R-MMU-1369062); (R-MMU-5683826)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11940594;16612327;17142808;17267394;17540762;17577581;20173027;20190032;25428506;26495903;26740625;28011936;28034695;30084848;30899004;31219806;31599954;34428180;35984892;37828378", "class_list": "", "function": "Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:17142808, PubMed:17267394, PubMed:17540762, PubMed:17577581, PubMed:20190032, PubMed:28034695). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:17142808). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3, [RefSeq, PubMed]; Showed for the first time expression and subcellular localization of abcb11 and abca3 in mouse kidney, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3L4", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005770 late endosome;GO:0097208 alveolar lamellar body", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0006869 lipid transport;GO:0010875 positive regulation of cholesterol efflux;GO:0043129 surfactant homeostasis;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8R420-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R493-1", "uniprot_id": [ { "id": "ACHB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R493", "type": "external" } ], "mass": 55809.0, "length": 495, "protein_name": "Neuronal acetylcholine receptor subunit beta-4", "gene_name": "Chrnb4", "organism": "Mouse", "refseq_name": "neuronal acetylcholine receptor subunit beta-4 precursor", "refseq_ac": [ { "id": "NP_683746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683746", "type": "external" } ], "gene_names_uniprotkb": "Chrnb4; Acrb4", "gene_names_refseq": "Acrb-4; Acrb4; Chrnb4", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-4", "protein_names_refseq": "neuronal acetylcholine receptor subunit beta-4 precursor; neuronal acetylcholine receptor subunit beta-4; nicotinic acetylcholine receptor beta4 subunit", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324); depressive disorder (Disease Ontology:DOID:1596); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine abuse (Disease Ontology:DOID:809); oral cavity cancer (Disease Ontology:DOID:8618)", "pathway": " (mmu:108015); (R-MMU-629587); (R-MMU-629594); (R-MMU-629597); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12225896;21555077;37879250;38902419", "class_list": "", "function": "Abundant extrasynaptic expression of alpha3beta4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:21555077). CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed:21555077). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 4, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI06", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030054 cell junction;GO:0045202 synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R493-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCV1-1", "uniprot_id": [ { "id": "AB17C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCV1", "type": "external" } ], "mass": 35098.0, "length": 320, "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "Abhd17c", "organism": "Mouse", "refseq_name": "alpha/beta hydrolase domain-containing protein 17C", "refseq_ac": [ { "id": "NP_598483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598483", "type": "external" } ], "gene_names_uniprotkb": "Abhd17c", "gene_names_refseq": "2210412D01Rik; Abhd17c; Fam108c1; Fam108c", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17C; 3.1.2.22; Abhydrolase domain-containing protein 17C", "protein_names_refseq": "abhydrolase domain-containing protein 17C; abhydrolase domain-containing protein FAM108C1; alpha/beta hydrolase domain-containing protein 17C; family with sequence similarity 108, member C; protein ABHD17C", "tax_id": 10090, "disease": "", "pathway": " (mmu:70178); (R-MMU-9648002)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26495903;27307232;34428180", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:0002084 protein depalmitoylation;GO:0099175 regulation of postsynapse organization;GO:1902817 negative regulation of protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VCV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEC3-1", "uniprot_id": [ { "id": "AGRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEC3", "type": "external" } ], "mass": 101469.0, "length": 908, "protein_name": "Adhesion G protein-coupled receptor F1", "gene_name": "Adgrf1", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor F1 precursor", "refseq_ac": [ { "id": "NP_598537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598537", "type": "external" } ], "gene_names_uniprotkb": "Adgrf1; Gpr110", "gene_names_refseq": "5031409J19Rik; Adgrf1; Gpr110; KPG_009", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F1; G protein-coupled receptor 110", "protein_names_refseq": "G protein coupled receptor Gpr110; G-protein coupled receptor 110; adhesion G-protein coupled receptor F1 precursor; internal gene name of KIRIN laboratory:M5", "tax_id": 10090, "disease": "", "pathway": " (mmu:77596)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22837050;27759003;30084848;30779550;36982411;37580715;37580962", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain (PubMed:27759003). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:27759003). ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:27759003). Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo (By similarity). Involved in the development of neurons and cognitive function (PubMed:27759003). In liver, involved in fat accumulation (PubMed:37580962)., [UniProtKB, UniProtKB, PubMed, PubMed]; Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1). Erratum:[Elife. 2024 Jan 22;13:e96183. doi: 10.7554/eLife.96183. PMID: 38252482] Publication Status: Online-Only, [RefSeq, PubMed]; Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrated orphan G-protein coupled receptor 110 (GPR110, ADGRF1) as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B0V2Q5;Q8BMV8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0031175 neuron projection development;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VEC3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924I3-1", "uniprot_id": [ { "id": "ACKR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924I3", "type": "external" } ], "mass": 39531.0, "length": 350, "protein_name": "Atypical chemokine receptor 4", "gene_name": "Ackr4", "organism": "Mouse", "refseq_name": "atypical chemokine receptor 4", "refseq_ac": [ { "id": "NP_663746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663746", "type": "external" } ], "gene_names_uniprotkb": "Ackr4; Ccr11; Ccrl1", "gene_names_refseq": "A630091E18Rik; Ackr4; CCBP2; CCR11; CCX-CKR1; CCX-CKR; Ccrl1; Cmkbrl1; PPR1; VSHK1", "protein_names_uniprotkb": "Atypical chemokine receptor 4; C-C CKR-11; C-C chemokine receptor type 11; CC chemokine receptor-like 1; CC-CKR-11; CCR-11; CCRL1; CCX CKR", "protein_names_refseq": "C-C CKR-11; C-C chemokine receptor type 11; CC chemokine receptor-like 1; CC-CKR-11; CCR-11; CCX CKR; atypical chemokine receptor 4; chemokine (C-C motif) receptor-like 1; chemokine (C-C) receptor-like 1; chemokine receptor CCR11", "tax_id": 10090, "disease": "", "pathway": " (mmu:252837); (R-MMU-380108)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11063828;11981810;17485674;20562329;23152546;37449198", "class_list": "", "function": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus and inhibits spontaneous autoimmunity., [UniProtKB, PubMed, PubMed]; CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in peripheral lymph nodes., [RefSeq, PubMed]; Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. (CCX-CKR), [RefSeq, PubMed]; Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension. Erratum:[Front Immunol. 2024 Feb 20;15:1382832. doi: 10.3389/fimmu.2024.1382832. PMID: 38444849] Publication Status: Online-Only, [RefSeq, PubMed]; These observations indicate that the silent chemokine receptor CCX-CKR1, regulates homeostatic leukocyte migration by controlling the availability of chemokines in the extracellular space., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0M1;Q8QZW9", "ec_number_list": [], "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0005044 scavenger receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q924I3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JW1-1", "uniprot_id": [ { "id": "AB17A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JW1", "type": "external" } ], "mass": 33950.0, "length": 310, "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "Abhd17a", "organism": "Mouse", "refseq_name": "alpha/beta hydrolase domain-containing protein 17A", "refseq_ac": [ { "id": "NP_663396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663396", "type": "external" } ], "gene_names_uniprotkb": "Abhd17a; D10Bwg1364e", "gene_names_refseq": "1700013O15Rik; Abhd17a; D10Bwg1364e; Fam108a", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17A; 3.1.2.22; Abhydrolase domain-containing protein 17A", "protein_names_refseq": "abhydrolase domain-containing protein 17A; abhydrolase domain-containing protein FAM108A; alpha/beta hydrolase domain-containing protein 17A; family with sequence similarity 108, member A; mFLJ00358 protein; protein ABHD17A", "tax_id": 10090, "disease": "", "pathway": " (mmu:216169); (R-MMU-9648002)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;26495903;28011936;34428180", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towars MAP6., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU54", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016607 nuclear speck;GO:0043197 dendritic spine", "go_biological_process": "GO:0044546 NLRP3 inflammasome complex assembly;GO:1905668 positive regulation of protein localization to endosome;GO:0072657 protein localization to membrane;GO:0002084 protein depalmitoylation;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99JW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9J3-1", "uniprot_id": [ { "id": "ACTT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9J3", "type": "external" } ], "mass": 42216.0, "length": 376, "protein_name": "Actin-related protein T1", "gene_name": "Actrt1", "organism": "Mouse", "refseq_name": "actin-related protein T1", "refseq_ac": [ { "id": "NP_082790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082790", "type": "external" } ], "gene_names_uniprotkb": "Actrt1", "gene_names_refseq": "1700061J02Rik; Actrt1; Arp-T1", "protein_names_uniprotkb": "Actin-related protein T1", "protein_names_refseq": "actin-related protein T1", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:73360)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35616329", "class_list": "", "function": "Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice., [RefSeq, PubMed]; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0008589 regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9J3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ59-1", "uniprot_id": [ { "id": "ABCB9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ59", "type": "external" } ], "mass": 83963.0, "length": 762, "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "Abcb9", "organism": "Mouse", "refseq_name": "ABC-type oligopeptide transporter ABCB9", "refseq_ac": [ { "id": "NP_063928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063928", "type": "external" } ], "gene_names_uniprotkb": "Abcb9; Kiaa1520", "gene_names_refseq": "Abcb9; TAPL; mKIAA1520", "protein_names_uniprotkb": "ABC-type oligopeptide transporter ABCB9; 7.4.2.6; ABC transporter 9 protein; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; TAP-like protein; TAPL; mABCB9", "protein_names_refseq": "ABC transporter 9 protein; ABC-type oligopeptide transporter ABCB9; ATP-binding cassette transporter 9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; TAP-like protein; mABCB9", "tax_id": 10090, "disease": "", "pathway": " (mmu:56325); (R-MMU-382556)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10748049;11011155;21750661;25428506;30084848;30779550;34428180;36195619", "class_list": "", "function": "ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored., [UniProtKB, UniProtKB]; The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase. Publication Status: Online-Only, [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may be associated with lysosome activity. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHA1;Q9D212;Q9JIN1", "ec_number_list": [ { "id": "7.4.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0015421 ABC-type oligopeptide transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0006518 peptide metabolic process;GO:0015833 peptide transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JJ59-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYL7-1", "uniprot_id": [ { "id": "ABT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYL7", "type": "external" } ], "mass": 30659.0, "length": 269, "protein_name": "Activator of basal transcription 1", "gene_name": "Abt1", "organism": "Mouse", "refseq_name": "activator of basal transcription 1", "refseq_ac": [ { "id": "NP_038952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038952", "type": "external" } ], "gene_names_uniprotkb": "Abt1", "gene_names_refseq": "Abt1", "protein_names_uniprotkb": "Activator of basal transcription 1", "protein_names_refseq": "activator of basal transcription 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:30946)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10648625;25428506", "class_list": "", "function": "Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGU7;Q9D762", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QYL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV35-1", "uniprot_id": [ { "id": "ABEC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV35", "type": "external" } ], "mass": 25660.0, "length": 224, "protein_name": "C->U-editing enzyme APOBEC-2", "gene_name": "Apobec2", "organism": "Mouse", "refseq_name": "C->U-editing enzyme APOBEC-2", "refseq_ac": [ { "id": "NP_033824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033824", "type": "external" } ], "gene_names_uniprotkb": "Apobec2", "gene_names_refseq": "Apobec2; Arp1", "protein_names_uniprotkb": "C->U-editing enzyme APOBEC-2; 3.5.4.36; mRNA(cytosine(6666)) deaminase 2", "protein_names_refseq": "C->U-editing enzyme APOBEC-2; apolipoprotein B editing complex 2; mRNA(cytosine(6666)) deaminase 2; probable C->U-editing enzyme APOBEC-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:11811); (R-MMU-72200); (R-MMU-75094)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10403781;12859895;25605945;29127187;30084848;34571854;37507081;38625936;39927985", "class_list": "", "function": "APOBEC2 safeguards skeletal muscle cell fate through binding chromatin and regulating transcription of non-muscle genes during myoblast differentiation., [RefSeq, PubMed]; Apobec2 deficiency causes mitochondrial defects that increase muscle mitophagy, leading to myopathy and atrophy. Findings demonstrate that Apobec2 is required for mitochondrial homeostasis to maintain normal skeletal muscle function., [RefSeq, PubMed]; PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs. Publication Status: Online-Only, [RefSeq, PubMed]; Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.-", "type": "external" }, { "id": "3.5.4.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.36", "type": "external" }, { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0016556 mRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WV35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UYH7-1", "uniprot_id": [ { "id": "GRK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UYH7", "type": "external" } ], "mass": 79657.0, "length": 688, "protein_name": "G protein-coupled receptor kinase 3", "gene_name": "Grk3", "organism": "Mouse", "refseq_name": "G protein-coupled receptor kinase 3 isoform 3", "refseq_ac": [ { "id": "NP_001272735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272735", "type": "external" } ], "gene_names_uniprotkb": "Grk3; Adrbk2", "gene_names_refseq": "4833444A01Rik; Adrbk-2; Adrbk2; Bark-2; Grk3", "protein_names_uniprotkb": "G protein-coupled receptor kinase 3; 2.7.11.15; 2.7.11.16; Beta-ARK-2; Beta-adrenergic receptor kinase 2", "protein_names_refseq": "G protein-coupled receptor kinase 3 isoform 3; adrenergic receptor kinase, beta 2; beta ARK2; beta-ARK-2; beta-adrenergic receptor kinase 2", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:320129); (R-MMU-418555); (R-MMU-8856825)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;30059200;33886552;35093170;37048054;38883814", "class_list": "", "function": "Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:33886552, PubMed:38883814). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:33886552, PubMed:38883814). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (PubMed:33886552)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8VPM8", "ec_number_list": [ { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0001664 G protein-coupled receptor binding;GO:0004703 G protein-coupled receptor kinase activity;GO:0047696 beta-adrenergic receptor kinase activity;GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0046154 rhodopsin metabolic process;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UYH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U829-1", "uniprot_id": [ { "id": "AP5Z1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U829", "type": "external" } ], "mass": 89407.0, "length": 807, "protein_name": "AP-5 complex subunit zeta-1", "gene_name": "Ap5z1", "organism": "Mouse", "refseq_name": "AP-5 complex subunit zeta-1", "refseq_ac": [ { "id": "NP_766313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766313", "type": "external" } ], "gene_names_uniprotkb": "Ap5z1; Kiaa0415", "gene_names_refseq": "Ap5z1; C330006K01Rik", "protein_names_uniprotkb": "AP-5 complex subunit zeta-1; Adaptor-related protein complex 5 zeta subunit; Zeta5", "protein_names_refseq": "AP-5 complex subunit zeta-1; adapter-related protein complex 5 zeta subunit; adaptor-related protein complex 5 zeta subunit; zeta5", "tax_id": 10090, "disease": "hereditary spastic paraplegia 48 (Disease Ontology:DOID:0110800); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:231855)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;37871017", "class_list": "", "function": "As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport., [UniProtKB]; Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJJ0;Q63ZW8;Q8BS06;Q8C488", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005764 lysosome", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006914 autophagy;GO:0007040 lysosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3U829-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61110-1", "uniprot_id": [ { "id": "ANRE_MOUSE", "url": "https://www.uniprot.org/uniprot/P61110", "type": "external" } ], "mass": 13263.0, "length": 121, "protein_name": "Kidney androgen-regulated protein", "gene_name": "Kap", "organism": "Mouse", "refseq_name": "kidney androgen-regulated protein precursor", "refseq_ac": [ { "id": "NP_034724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034724", "type": "external" } ], "gene_names_uniprotkb": "Kap", "gene_names_refseq": "FKSG22; Kap", "protein_names_uniprotkb": "Kidney androgen-regulated protein; ARP; KAP", "protein_names_refseq": "ARP; kidney androgen-regulated protein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:16483)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19332469;1991048;21750661;21906672;21980535;2739660;31044023", "class_list": "", "function": "Overexpression of this gene induces hypertension and chronic renal disease., [RefSeq, PubMed]; Transgenic mice overexpressing protein specifically in kidney show hypertension associated with oxidative stress, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P15267", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61110-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97449-1", "uniprot_id": [ { "id": "AMPN_MOUSE", "url": "https://www.uniprot.org/uniprot/P97449", "type": "external" } ], "mass": 109651.0, "length": 966, "protein_name": "Aminopeptidase N", "gene_name": "Anpep", "organism": "Mouse", "refseq_name": "aminopeptidase N", "refseq_ac": [ { "id": "NP_032512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032512", "type": "external" } ], "gene_names_uniprotkb": "Anpep; Lap-1; Lap1", "gene_names_refseq": "AP-M; AP-N; Anpep; Apn; Cd13; P150", "protein_names_uniprotkb": "Aminopeptidase N; 3.4.11.2; AP-M; AP-N; Alanyl aminopeptidase; Aminopeptidase M; Membrane protein p161; Microsomal aminopeptidase; mAPN", "protein_names_refseq": "alanyl (membrane) aminopeptidase; alanyl aminopeptidase; aminopeptidase M; aminopeptidase N/CD13; aminopeptidase N; membrane protein p161; microsomal aminopeptidase", "tax_id": 10090, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:16790); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;17947660;19349973;19656770;19892989;21750661;22677001;26495903;26740625;28011936;30084848;30899004;31219806;32152506;34428180;35820727;35984892;37817190;39324816;8103749;8691132;8805662", "class_list": "", "function": "Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection., [RefSeq, PubMed]; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells (PubMed:8691132). May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (PubMed:22677001)., [UniProtKB, PubMed, UniProtKB, PubMed]; CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 13, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q91YH8;Q99K63", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0042277 peptide binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0002003 angiotensin maturation;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P97449-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56404-1", "uniprot_id": [ { "id": "AQP8_MOUSE", "url": "https://www.uniprot.org/uniprot/P56404", "type": "external" } ], "mass": 27797.0, "length": 261, "protein_name": "Aquaporin-8", "gene_name": "Aqp8", "organism": "Mouse", "refseq_name": "aquaporin-8 isoform 2", "refseq_ac": [ { "id": "NP_001102515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102515", "type": "external" } ], "gene_names_uniprotkb": "Aqp8", "gene_names_refseq": "AQP-8; Aqp8", "protein_names_uniprotkb": "Aquaporin-8; AQP-8", "protein_names_refseq": "aquaporin-8 isoform 2", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:11833); (R-MMU-432047)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10449905;14512882;15647389;15859952;15948717;16624991;21117174;21602842;21750661;27256569;34428180;34540996;37280594;9388476", "class_list": "", "function": "AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues (PubMed:15647389, PubMed:15948717, PubMed:16624991, PubMed:21117174, PubMed:27256569, PubMed:9388476). The transport of ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (By similarity). However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (By similarity). Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion (By similarity). In vitro, may be also permeable to urea but not to glycerol (PubMed:9388476). Does not transport urea or glycerol (By similarity). The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (PubMed:9388476). At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (By similarity). In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (By similarity). In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (PubMed:27256569). In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (By similarity). May play an important role in the adaptive response of proximal tubule cells to acidosis possibly facilitating mitochondrial ammonia transport (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XC2", "ec_number_list": [], "go_molecular_function": "GO:0015250 water channel activity;GO:0015265 urea channel activity;GO:0008519 ammonium channel activity;GO:0015264 methylammonium channel activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0015722 canalicular bile acid transport;GO:0045540 regulation of cholesterol biosynthetic process;GO:0030183 B cell differentiation;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P56404-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHH1-1", "uniprot_id": [ { "id": "AQP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHH1", "type": "external" } ], "mass": 30481.0, "length": 271, "protein_name": "Aquaporin-11", "gene_name": "Aqp11", "organism": "Mouse", "refseq_name": "aquaporin-11", "refseq_ac": [ { "id": "NP_780314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780314", "type": "external" } ], "gene_names_uniprotkb": "Aqp11", "gene_names_refseq": "1700015P13Rik; Aqp11; sjds", "protein_names_uniprotkb": "Aquaporin-11; AQP-11", "protein_names_refseq": "AQP-11; CG12251 gene product; aquaporin-11", "tax_id": 10090, "disease": "", "pathway": " (mmu:66333); (R-MMU-432047)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "16107722;18606867;18701606;19812234;21118806;21251984;21750661;23275615;23486012;24854278;27107718;27582095;30656220;33794341", "class_list": "", "function": "AQP11 is essential for the proximal tubular function, [RefSeq, PubMed]; Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:21118806, PubMed:21251984). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:23275615, PubMed:30656220). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (PubMed:18606867, PubMed:24854278). Plays a role in the proximal tubule function by regulating its endosomal acidification (PubMed:16107722). May play a role in postnatal kidney development (PubMed:18701606, PubMed:23486012, PubMed:27582095)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Effects of osmolality on the expression of brain aquaporins in AQP11-null mice., [RefSeq, PubMed]; Mutation causing single amino acid substitution in aquaporin 11 causes renal failure in sudden juvenile death syndrome mutant mice, [RefSeq, PubMed]; These results provide new insights into the physiological roles of AQP11., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZU1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015267 channel activity;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0140070 hydrogen peroxide channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051260 protein homooligomerization;GO:0001822 kidney development;GO:0006612 protein targeting to membrane;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BHH1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34928-1", "uniprot_id": [ { "id": "APOC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P34928", "type": "external" } ], "mass": 9696.0, "length": 88, "protein_name": "Apolipoprotein C-I", "gene_name": "Apoc1", "organism": "Mouse", "refseq_name": "apolipoprotein C-I precursor", "refseq_ac": [ { "id": "NP_001103479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103479", "type": "external" } ], "gene_names_uniprotkb": "Apoc1", "gene_names_refseq": "Apo-CIB; ApoC-IB; Apoc1; apo-CI; apoC-I", "protein_names_uniprotkb": "Apolipoprotein C-I; Apo-CI; ApoC-I; Apolipoprotein C1", "protein_names_refseq": "apolipoprotein C-I precursor; apolipoprotein C1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); gastric adenocarcinoma (Disease Ontology:DOID:3717); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11812); (R-MMU-8866423); (R-MMU-8964046)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12070157;16876491;17339654;21157034;21750661;22404376;31219806;34428180;36891052;37981873;8276416", "class_list": "", "function": "APOC1 as a novel diagnostic biomarker for DN based on machine learning algorithms and experiment. Publication Status: Online-Only, [RefSeq, PubMed]; Apolipoprotein C-I was significantly increased in obese mice plasma., [RefSeq, PubMed]; Data suggest that apoC-I binds free fatty acids (FFA), thereby reducing the blood FFA for uptake by cells, and this mechanism can serve as an additional mechanism for the resistance to obesity and the cutaneous abnormalities of APOC1(+/+) mice., [RefSeq, PubMed]; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification., [UniProtKB, UniProtKB, UniProtKB, PubMed]; MiRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFbeta2 signaling pathway., [RefSeq, PubMed]; Present observations provide direct support for a potent specific inhibition of CETP by plasma apoCI in vivo, [RefSeq, PubMed]; The absence of ApoC-I results in impaired memory functions, which is, together with previous data, suggestive of an important, bell-shaped gene-dose dependent role for ApoC-I in appropriate brain functioning, [RefSeq, PubMed]; This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505B2", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0055102 lipase inhibitor activity;GO:0004859 phospholipase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P34928-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54984-1", "uniprot_id": [ { "id": "GET3_MOUSE", "url": "https://www.uniprot.org/uniprot/O54984", "type": "external" } ], "mass": 38823.0, "length": 348, "protein_name": "ATPase GET3", "gene_name": "Get3", "organism": "Mouse", "refseq_name": "ATPase GET3 isoform 1", "refseq_ac": [ { "id": "NP_062626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062626", "type": "external" } ], "gene_names_uniprotkb": "Get3; Arsa; Asna1", "gene_names_refseq": "1810048H22Rik; ArsA; Asna1; Get3", "protein_names_uniprotkb": "ATPase GET3; 3.6.4.-; Arsenical pump-driving ATPase; Arsenite-stimulated ATPase; Guided entry of tail-anchored proteins factor 3, ATPase", "protein_names_refseq": "ATPase Asna1; ATPase GET3 isoform 1; ATPase GET3; arsenical pump-driving ATPase; arsenite-stimulated ATPase; arsenite-translocating ATPase", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:56495)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11470536;16797549;21750661;25605945;26438609;29180572;31219806;34203471;34428180;36852467", "class_list": "", "function": "ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling., [UniProtKB, UniProtKB, HAMAP]; Asna1 ensures retrograde transport and ER and insulin homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin secretion, and glucose intolerance that rapidly progresses to overt diabetes., [RefSeq, PubMed]; These findings indicate that Asna1 plays a crucial role during early embryonic development., [RefSeq, PubMed]; These findings support a role for the Asna1 ATPase activity in ensuring the survival of pancreatic multipotent progenitor cells , possibly by counteracting p53-mediated apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAQ4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0032977 membrane insertase activity;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O54984-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P068-1", "uniprot_id": [ { "id": "ARL5C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P068", "type": "external" } ], "mass": 20059.0, "length": 179, "protein_name": "ADP-ribosylation factor-like protein 5C", "gene_name": "Arl5c", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 5C", "refseq_ac": [ { "id": "NP_997114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997114", "type": "external" } ], "gene_names_uniprotkb": "Arl5c; Arl12", "gene_names_refseq": "Arl12; Arl5c", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 5C; ADP-ribosylation factor-like protein 12", "protein_names_refseq": "ADP-ribosylation factor-like 12; ADP-ribosylation factor-like 5C protein; ADP-ribosylation factor-like protein 12; ADP-ribosylation factor-like protein 5C", "tax_id": 10090, "disease": "", "pathway": " (mmu:217151)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Binds and exchanges GTP and GDP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBK5", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P068-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSL7-1", "uniprot_id": [ { "id": "ARF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSL7", "type": "external" } ], "mass": 20746.0, "length": 181, "protein_name": "ADP-ribosylation factor 2", "gene_name": "Arf2", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor 2", "refseq_ac": [ { "id": "NP_001291503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291503", "type": "external" } ], "gene_names_uniprotkb": "Arf2", "gene_names_refseq": "Arf2", "protein_names_uniprotkb": "ADP-ribosylation factor 2", "protein_names_refseq": "ADP-ribosylation factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:11841)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;33300544;38227057;8947846", "class_list": "", "function": "Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Publication Status: Online-Only, [RefSeq, PubMed]; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10947;P16500;Q3TJ37;Q91VR9", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BSL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6PWV5-1", "uniprot_id": [ { "id": "ARI3C_MOUSE", "url": "https://www.uniprot.org/uniprot/A6PWV5", "type": "external" } ], "mass": 43633.0, "length": 409, "protein_name": "AT-rich interactive domain-containing protein 3C", "gene_name": "Arid3c", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 3C isoform 1", "refseq_ac": [ { "id": "NP_001017362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017362", "type": "external" } ], "gene_names_uniprotkb": "Arid3c", "gene_names_refseq": "Arid3c", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 3C; ARID domain-containing protein 3C", "protein_names_refseq": "ARID domain-containing protein 3C; AT rich interactive domain 3C (BRIGHT-like); AT rich interactive domain 3C (Bright like); AT-rich interactive domain-containing protein 3C isoform 1; AT-rich interactive domain-containing protein 3C", "tax_id": 10090, "disease": "", "pathway": " (mmu:550619)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21955986;31219806", "class_list": "", "function": "This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]., [RefSeq]; This report introduces Brightlike as an additional functional member of the family of ARID proteins, which should be considered in regulatory circuits, previously ascribed to be mediated by Bright.[ARID3C], [RefSeq, PubMed]; Transcription factor involved in monocyte-to-macrophage differentiation. Forms a complex with NPM1 to translocate to the nucleus, acting as a transcription factor that promotes the expression of the genes involved in macrophage differentiation, such as STAT3, STAT1 and JUNB., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RUN0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045121 membrane raft", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030225 macrophage differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6PWV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61205-1", "uniprot_id": [ { "id": "ARF3_MOUSE", "url": "https://www.uniprot.org/uniprot/P61205", "type": "external" } ], "mass": 20601.0, "length": 181, "protein_name": "ADP-ribosylation factor 3", "gene_name": "Arf3", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor 3", "refseq_ac": [ { "id": "NP_031504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031504", "type": "external" } ], "gene_names_uniprotkb": "Arf3", "gene_names_refseq": "5430400P17Rik; Arf3", "protein_names_uniprotkb": "ADP-ribosylation factor 3", "protein_names_refseq": "ADP-ribosylation factor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:11842); (R-MMU-1660514); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "21750661;26067373;31539530;33300544;37453647;37507081;37828378;38227057;39627609;8947846", "class_list": "", "function": "ARF3 promotes breast cancer cell proliferation through the participation of FOXO1., [RefSeq, PubMed]; Activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex., [RefSeq, PubMed]; Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Publication Status: Online-Only, [RefSeq, PubMed]; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16587", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61205-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNS7-1", "uniprot_id": [ { "id": "ASIC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNS7", "type": "external" } ], "mass": 59216.0, "length": 539, "protein_name": "Acid-sensing ion channel 4", "gene_name": "Asic4", "organism": "Mouse", "refseq_name": "acid-sensing ion channel 4", "refseq_ac": [ { "id": "NP_898843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898843", "type": "external" } ], "gene_names_uniprotkb": "Asic4; Accn4", "gene_names_refseq": "Accn4; Asic4; BNAC4", "protein_names_uniprotkb": "Acid-sensing ion channel 4; ASIC4; Amiloride-sensitive cation channel 4", "protein_names_refseq": "acid-sensing (proton-gated) ion channel family member 4; acid-sensing ion channel 4; amiloride-sensitive cation channel 4, pituitary", "tax_id": 10090, "disease": "", "pathway": " (mmu:241118); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25828470;28461138;30899004", "class_list": "", "function": "Does not exhibit measurable stand-alone pH-gated sodium channel activity but may form pH-gated heterotrimeric sodium channels. Its activity could also depend on alternative gating mechanisms., [UniProtKB, UniProtKB]; Study employed a radioactive in situ hybridization method to thoroughly investigate the distribution of Acid-sensing ion channel 4 (ASIC4) transcripts in the adult wild-type mouse brain. The resultant data indicate that the ASIC4 mRNAs were substantially expressed in many areas of the brain., [RefSeq, PubMed]; This study demonstrated that ASIC4 may modulate fear and anxiety by counteracting ASIC1a activity in the brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q80XK4", "ec_number_list": [], "go_molecular_function": "GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001662 behavioral fear response;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q7TNS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64362-1", "uniprot_id": [ { "id": "AKTIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64362", "type": "external" } ], "mass": 32942.0, "length": 292, "protein_name": "AKT-interacting protein", "gene_name": "Aktip", "organism": "Mouse", "refseq_name": "AKT-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_001289195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289195", "type": "external" } ], "gene_names_uniprotkb": "Aktip; Fif; Ft1; Fts", "gene_names_refseq": "AL023020; Aktip; Fif; Ft1; Fts; Ft", "protein_names_uniprotkb": "AKT-interacting protein; FT1; Fused toes protein", "protein_names_refseq": "AKT-interacting protein isoform 1; fused toes protein; thymoma viral proto-oncogene 1 interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14339)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;22872234;25428506;30084848;36096808;37960940;7956835;9383278", "class_list": "", "function": "Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYE3", "ec_number_list": [], "go_molecular_function": "GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070695 FHF complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0015031 protein transport;GO:0006915 apoptotic process;GO:0007032 endosome organization;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64362-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97384-1", "uniprot_id": [ { "id": "ANX11_MOUSE", "url": "https://www.uniprot.org/uniprot/P97384", "type": "external" } ], "mass": 54079.0, "length": 503, "protein_name": "Annexin A11", "gene_name": "Anxa11", "organism": "Mouse", "refseq_name": "annexin A11", "refseq_ac": [ { "id": "NP_038497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038497", "type": "external" } ], "gene_names_uniprotkb": "Anxa11; Anx11", "gene_names_refseq": "100039484; 100039503; A830099O17Rik; Anx11; Anxa11; Gm2260; Gm2274", "protein_names_uniprotkb": "Annexin A11; Annexin XI; Annexin-11; CAP-50; Calcyclin-associated annexin 50", "protein_names_refseq": "Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50); CAP-50; annexin A11; annexin XI; annexin-11; calcyclin-associated annexin 50", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 23 (Disease Ontology:DOID:0080225); inclusion body myopathy and brain white matter abnormalities (Disease Ontology:DOID:0081121)", "pathway": " (mmu:11744)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11013079;21750661;25428506;25776480;26740625;26908448;30084848;30779550;34428180;35820727;37507081;39627609;8938449", "class_list": "", "function": "ANXA11 level regulates lymph node metastases and 5-FU resistance of Hca-P murine hepatocarcinoma cells via c-Jun pathway, [RefSeq, PubMed]; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner., [UniProtKB]; This study showed that Annexin A11 knockdown inhibits the in vitro proliferation and cell apoptosis of Hca-F cell via Akt2/FoxO1 and/or MMP-9 expression pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921F1", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0051592 response to calcium ion;GO:0006909 phagocytosis;GO:0032506 cytokinetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97384-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61211-1", "uniprot_id": [ { "id": "ARL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61211", "type": "external" } ], "mass": 20412.0, "length": 181, "protein_name": "ADP-ribosylation factor-like protein 1", "gene_name": "Arl1", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 1", "refseq_ac": [ { "id": "NP_080135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080135", "type": "external" } ], "gene_names_uniprotkb": "Arl1", "gene_names_refseq": "2310008D22Rik; Arl1", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 1", "protein_names_refseq": "ADP-ribosylation factor-like protein 1; ADP-ribosylation-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:104303); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17127620;21750661;25428506;28135057;33300544;34428180;37507081", "class_list": "", "function": "GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P41276", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008047 enzyme activator activity;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0009404 toxin metabolic process;GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P61211-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7E2-1", "uniprot_id": [ { "id": "ARID2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7E2", "type": "external" } ], "mass": 195988.0, "length": 1828, "protein_name": "AT-rich interactive domain-containing protein 2", "gene_name": "Arid2", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 2", "refseq_ac": [ { "id": "NP_780460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780460", "type": "external" } ], "gene_names_uniprotkb": "Arid2; Baf200", "gene_names_refseq": "1700124K17Rik; 4432409D24Rik; Arid2; BAF200; zipzap/p200", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 2; ARID domain-containing protein 2; BAF200; BRG1-associated factor 200; Zinc finger protein with activation potential; Zipzap/p200", "protein_names_refseq": "ARID domain-containing protein 2; AT rich interactive domain 2 (ARID, RFX-like); AT rich interactive domain 2 (Arid-rfx like); AT-rich interactive domain-containing protein 2; BRG1-associated factor 200; zinc finger protein with activation potential; zipzap", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Coffin-Siris syndrome 6 (Disease Ontology:DOID:0080297); alcohol use disorder (Disease Ontology:DOID:1574); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:77044)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16782067;22645316;22952240;25428506;25605945;26601204;34203471;34428180;35820727;36210013;40885482;40997131", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016514 SWI/SNF complex;GO:0016363 nuclear matrix;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0072359 circulatory system development;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "E9Q7E2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50428-1", "uniprot_id": [ { "id": "ARSA_MOUSE", "url": "https://www.uniprot.org/uniprot/P50428", "type": "external" } ], "mass": 53748.0, "length": 506, "protein_name": "Arylsulfatase A", "gene_name": "Arsa", "organism": "Mouse", "refseq_name": "arylsulfatase A precursor", "refseq_ac": [ { "id": "NP_033843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033843", "type": "external" } ], "gene_names_uniprotkb": "Arsa; As2", "gene_names_refseq": "AS-A; ASA; Arsa; As-2; As2; TISP73", "protein_names_uniprotkb": "Arylsulfatase A; 3.1.6.8; ASA; Cerebroside-sulfatase", "protein_names_refseq": "arylsulfatase A precursor; cerebroside-sulfatase", "tax_id": 10090, "disease": "metachromatic leukodystrophy (Disease Ontology:DOID:10581); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:11883); (R-MMU-1663150); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;1572648;21750661;24294900;26740625;30899004;31219806;35273160;7910580", "class_list": "glycogene", "function": "Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes cerebroside sulfate., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC66", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity;GO:0004098 cerebroside-sulfatase activity;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007339 binding of sperm to zona pellucida;GO:0007584 response to nutrient;GO:0045471 response to ethanol;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P50428-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18293-1", "uniprot_id": [ { "id": "ANPRA_MOUSE", "url": "https://www.uniprot.org/uniprot/P18293", "type": "external" } ], "mass": 119109.0, "length": 1057, "protein_name": "Atrial natriuretic peptide receptor 1", "gene_name": "Npr1", "organism": "Mouse", "refseq_name": "atrial natriuretic peptide receptor 1 precursor", "refseq_ac": [ { "id": "NP_032753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032753", "type": "external" } ], "gene_names_uniprotkb": "Npr1; Npra", "gene_names_refseq": "GC-A; NPR-A; NPRA; Npr1; Pndr", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 1; 4.6.1.2; ANP-A; ANPR-A; Atrial natriuretic peptide receptor type A; GC-A; Guanylate cyclase A; NPR-A", "protein_names_refseq": "ANP-A; ANPR-A; Nppa receptor; atrial natriuretic peptide receptor 1 precursor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor type A; guanylate cyclase A; guanylyl cyclase-A", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:18160); (R-MMU-5578768)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;1973687;21750661;35794311;35820727;37356621;39109516;7838126;9405681", "class_list": "", "function": "Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi., [RefSeq, PubMed]; Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice., [RefSeq, PubMed]; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:35794311). Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042562 hormone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0043235 receptor complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0008217 regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P18293-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVF9-1", "uniprot_id": [ { "id": "AMZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVF9", "type": "external" } ], "mass": 55284.0, "length": 502, "protein_name": "Archaemetzincin-1", "gene_name": "Amz1", "organism": "Mouse", "refseq_name": "archaemetzincin-1", "refseq_ac": [ { "id": "NP_775581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775581", "type": "external" } ], "gene_names_uniprotkb": "Amz1", "gene_names_refseq": "5330426I05; 6530401C20Rik; Amz1", "protein_names_uniprotkb": "Archaemetzincin-1; 3.4.-.-; Archeobacterial metalloproteinase-like protein 1", "protein_names_refseq": "archaemetzincin-1; archeobacterial metalloproteinase-like 1; archeobacterial metalloproteinase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231842)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15972818;21750661;34428180", "class_list": "", "function": "Probable zinc metalloprotease., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811F9;Q8BMM5", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BVF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54794-1", "uniprot_id": [ { "id": "AQP7_MOUSE", "url": "https://www.uniprot.org/uniprot/O54794", "type": "external" } ], "mass": 32667.0, "length": 303, "protein_name": "Aquaporin-7", "gene_name": "Aqp7", "organism": "Mouse", "refseq_name": "aquaporin-7 isoform 2", "refseq_ac": [ { "id": "NP_031499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031499", "type": "external" } ], "gene_names_uniprotkb": "Aqp7", "gene_names_refseq": "AQP7L; AQPap; Aqp7", "protein_names_uniprotkb": "Aquaporin-7; AQP-7; Aquaglyceroporin-7", "protein_names_refseq": "AQP-7; aquaglyceroporin-7; aquaporin-7 isoform 2", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); morbid obesity (Disease Ontology:DOID:11981); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11832); (R-MMU-432030); (R-MMU-432047)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15591341;15746100;15998844;16009937;17077387;17576812;25643985;34807469;37432580;37691043;37879294;38064372", "class_list": "", "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea (By similarity). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues (PubMed:15591341, PubMed:15746100, PubMed:16009937). In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis (PubMed:15998844, PubMed:17077387). In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (PubMed:17576812)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells., [RefSeq, PubMed]; Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport., [RefSeq, PubMed]; Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice., [RefSeq, PubMed]; Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice., [RefSeq, PubMed]; LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C630", "ec_number_list": [], "go_molecular_function": "GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015265 urea channel activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006833 water transport;GO:0015793 glycerol transmembrane transport;GO:0015840 urea transport;GO:0070295 renal water absorption", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O54794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88879-1", "uniprot_id": [ { "id": "APAF_MOUSE", "url": "https://www.uniprot.org/uniprot/O88879", "type": "external" } ], "mass": 141003.0, "length": 1249, "protein_name": "Apoptotic protease-activating factor 1", "gene_name": "Apaf1", "organism": "Mouse", "refseq_name": "apoptotic protease-activating factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001036023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036023", "type": "external" } ], "gene_names_uniprotkb": "Apaf1", "gene_names_refseq": "6230400I06Rik; Apaf-1; Apaf1l; Apaf1; fog; mKIAA0413", "protein_names_uniprotkb": "Apoptotic protease-activating factor 1; APAF-1", "protein_names_refseq": "apoptotic protease-activating factor 1 isoform 1; apoptotic protease-activating factor 1; forebrain overgrowth", "tax_id": 10090, "disease": "amelogenesis imperfecta type 1B (Disease Ontology:DOID:0110052); amelogenesis imperfecta type 1C (Disease Ontology:DOID:0110056); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:11783); (R-MMU-111458); (R-MMU-111459); (R-MMU-6798695); (R-MMU-9627069)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11119689;15262985;15271982;21750661;21827944;31219806;9753320", "class_list": "", "function": "Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RRK8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0043531 ADP binding;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043293 apoptosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0030154 cell differentiation;GO:0030900 forebrain development;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88879-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06728-1", "uniprot_id": [ { "id": "APOA4_MOUSE", "url": "https://www.uniprot.org/uniprot/P06728", "type": "external" } ], "mass": 45029.0, "length": 395, "protein_name": "Apolipoprotein A-IV", "gene_name": "Apoa4", "organism": "Mouse", "refseq_name": "apolipoprotein A-IV precursor", "refseq_ac": [ { "id": "NP_031494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031494", "type": "external" } ], "gene_names_uniprotkb": "Apoa4", "gene_names_refseq": "Apoa-4; Apoa4; apo-AIV; apoA-IV", "protein_names_uniprotkb": "Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4", "protein_names_refseq": "apolipoprotein A-IV precursor; apolipoprotein A4", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colitis (Disease Ontology:DOID:0060180); autosomal dominant tubulointerstitial kidney disease 6 (Disease Ontology:DOID:0061121); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); Guillain-Barre syndrome (Disease Ontology:DOID:12842); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); polyneuropathy (Disease Ontology:DOID:1389); major depressive disorder (Disease Ontology:DOID:1470); glaucoma (Disease Ontology:DOID:1686); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); retinal detachment (Disease Ontology:DOID:5327); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (mmu:11808); (R-MMU-8963888); (R-MMU-8963901); (R-MMU-975634)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1648102;16876491;34428180;35909347;3796595;38004234;39627609", "class_list": "", "function": "Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background Are Susceptible to Obesity and Glucose Intolerance. Publication Status: Online-Only, [RefSeq, PubMed]; Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling., [RefSeq, PubMed]; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XF8", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06728-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20443-1", "uniprot_id": [ { "id": "ARRS_MOUSE", "url": "https://www.uniprot.org/uniprot/P20443", "type": "external" } ], "mass": 44930.0, "length": 403, "protein_name": "S-arrestin", "gene_name": "Sag", "organism": "Mouse", "refseq_name": "S-arrestin", "refseq_ac": [ { "id": "NP_033144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033144", "type": "external" } ], "gene_names_uniprotkb": "Sag", "gene_names_refseq": "A930001K18Rik; Arr1; Irbp; Sag; arrestin", "protein_names_uniprotkb": "S-arrestin; 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin; S-AG", "protein_names_refseq": "48 kDa protein; S-AG; S-arrestin; arrestin 1; retinal S-antigen; rod arrestin; rod photoreceptor arrestin; visual arrestin 1", "tax_id": 10090, "disease": "retinitis pigmentosa 96 (Disease Ontology:DOID:0061104); retinitis pigmentosa 47 (Disease Ontology:DOID:0110369); Oguchi disease-1 (Disease Ontology:DOID:0110712); hereditary night blindness (Disease Ontology:DOID:8498)", "pathway": " (mmu:20215); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16421323;21288033;26200343;28753425;2977355;36766830;9333241", "class_list": "", "function": "Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G proteins by competing with G proteins for the same binding site on RHO (PubMed:16421323, PubMed:9333241). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:16421323)., [UniProtKB, PubMed, PubMed]; The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W62", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0051219 phosphoprotein binding;GO:0030507 spectrin binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0016020 membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007165 signal transduction;GO:0007600 sensory perception;GO:0002031 G protein-coupled receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20443-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21570-1", "uniprot_id": [ { "id": "ANGI_MOUSE", "url": "https://www.uniprot.org/uniprot/P21570", "type": "external" } ], "mass": 16228.0, "length": 145, "protein_name": "Angiogenin", "gene_name": "Ang", "organism": "Mouse", "refseq_name": "angiogenin precursor", "refseq_ac": [ { "id": "NP_001155203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155203", "type": "external" } ], "gene_names_uniprotkb": "Ang; Ang1; Rnase5a; Rnase5", "gene_names_refseq": "Ang1; Ang; Rnase5a; Rnase5", "protein_names_uniprotkb": "Angiogenin; 3.1.27.-; Angiogenin-1; RNase 5; Ribonuclease 5", "protein_names_refseq": "angiogenin precursor; angiogenin, ribonuclease A family, member 1; angiogenin-1; ribonuclease 5", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 9 (Disease Ontology:DOID:0060200); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); eosinophilic esophagitis (Disease Ontology:DOID:13922); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cerebral infarction (Disease Ontology:DOID:3526); trophoblastic neoplasm (Disease Ontology:DOID:4085); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:11727); (R-MMU-418990)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15722482;16301790;19114040;2222458;24752898;27518564;29100074;32510170;33758201;33986151;36881568;37051927;8448182", "class_list": "", "function": "Adenosine-ADORA2A Promotes Ang-Induced Angiogenesis in Intrauterine Growth Restriction Placenta via the Stat3/Akt Pathway., [RefSeq, PubMed]; Ang1 and Ang4 differentially affect colitis and carcinogenesis in an AOM-DSS mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; RNase 4 and RNase 5/ang 1 are unique among the RNase A ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing. Publication Status: Online-Only, [RefSeq, PubMed]; Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context (PubMed:19114040, PubMed:27518564, PubMed:32510170, PubMed:33758201, PubMed:33986151). Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus (PubMed:29100074, PubMed:33758201). Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (PubMed:19114040, PubMed:24752898, PubMed:33986151). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (PubMed:24752898). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36 (By similarity). Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec) (By similarity). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation (By similarity). Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription (By similarity). Involved in hematopoietic stem and progenitor cell (HSPC) growth and survival by promoting rRNA transcription in growth conditions and inhibiting translation in response to stress, respectively (PubMed:27518564). Mediates the crosstalk between myeloid and intestinal epithelial cells to protect the intestinal epithelial barrier integrity: secreted by myeloid cells and promotes intestinal epithelial cells proliferation and survival (PubMed:32510170). Also mediates osteoclast-endothelial cell crosstalk in growing bone: produced by osteoclasts and protects the neighboring vascular cells against senescence by promoting rRNA transcription (PubMed:33758201)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0001878 response to yeast;GO:0007165 signal transduction;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P21570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31955-1", "uniprot_id": [ { "id": "AREG_MOUSE", "url": "https://www.uniprot.org/uniprot/P31955", "type": "external" } ], "mass": 27549.0, "length": 248, "protein_name": "Amphiregulin", "gene_name": "Areg", "organism": "Mouse", "refseq_name": "amphiregulin preproprotein", "refseq_ac": [ { "id": "NP_033834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033834", "type": "external" } ], "gene_names_uniprotkb": "Areg; Sdgf", "gene_names_refseq": "AR; Areg; Mcub; Sdgf", "protein_names_uniprotkb": "Amphiregulin; AR; SDGF; Schwannoma-derived growth factor", "protein_names_refseq": "amphiregulin preproprotein; schwannoma-derived growth factor", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:11839); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-204005); (R-MMU-212718); (R-MMU-5673001); (R-MMU-5694530); (R-MMU-6811558); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9009391)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "1318038;8592515", "class_list": "", "function": "Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts., [UniProtKB]; This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0042542 response to hydrogen peroxide;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31955-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53762-1", "uniprot_id": [ { "id": "ARNT_MOUSE", "url": "https://www.uniprot.org/uniprot/P53762", "type": "external" } ], "mass": 86963.0, "length": 791, "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "Arnt", "organism": "Mouse", "refseq_name": "aryl hydrocarbon receptor nuclear translocator isoform a", "refseq_ac": [ { "id": "NP_001032826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032826", "type": "external" } ], "gene_names_uniprotkb": "Arnt", "gene_names_refseq": "Arnt; D3Ertd557e; Drnt; ESTM42; Hif1b; bHLHe2; mKIAA4051", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Dioxin receptor, nuclear translocator; HIF-1-beta; HIF1-beta; Hypoxia-inducible factor 1-beta", "protein_names_refseq": "HIF-1-beta; HIF1-beta; aryl hydrocarbon receptor nuclear translocator isoform a; dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); renal cell carcinoma (Disease Ontology:DOID:4450); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11863); (R-MMU-1234158); (R-MMU-211945); (R-MMU-211976); (R-MMU-211981); (R-MMU-8937144); (R-MMU-9768919)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "11025203;21183079;21750661;24001774;25428506;26245371;27782878;28602820;30084848;31219806;32782141;32848054;34428180;36852467;37172753;40885482;7961746;8065341;9887096", "class_list": "", "function": "Evidence for crosstalk between the aryl hydrocarbon receptor and the translocator protein in mouse lung epithelial cells., [RefSeq, PubMed]; Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target gene promoters (PubMed:28602820). Also heterodimerizes with hypoxia-inducible factor alpha subunits (HIF1A, EPAS1, NPAS1 or NPAS3) to form hypoxia-inducible transcription factors that bind hypoxia response elements (HREs) and activate genes involved in cellular and systemic responses to hypoxia, including angiogenesis, erythropoiesis, and metabolic adaptation (PubMed:26245371, PubMed:27782878). Plays a central role in environmental sensing and developmental and physiological regulation of gene expression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q60661;Q921F3", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0017162 aryl hydrocarbon receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P53762-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56402-1", "uniprot_id": [ { "id": "AQP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P56402", "type": "external" } ], "mass": 28965.0, "length": 271, "protein_name": "Aquaporin-2", "gene_name": "Aqp2", "organism": "Mouse", "refseq_name": "aquaporin-2", "refseq_ac": [ { "id": "NP_033829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033829", "type": "external" } ], "gene_names_uniprotkb": "Aqp2; cph", "gene_names_refseq": "AQP-CD; Aqp2; WCH-CD; cph; jpk", "protein_names_uniprotkb": "Aquaporin-2; ADH water channel; AQP-2; AQP-CD; Aquaporin-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct", "protein_names_refseq": "ADH water channel; AQP-2; aquaporin-2; aquaporin-CD; collecting duct water channel protein; water channel protein for renal collecting duct", "tax_id": 10090, "disease": "nephrogenic diabetes insipidus type 2 (Disease Ontology:DOID:0081061); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); diabetic ketoacidosis (Disease Ontology:DOID:1837); diabetes insipidus (Disease Ontology:DOID:9409)", "pathway": " (mmu:11827); (R-MMU-432040); (R-MMU-432047)", "pathway_count": 3, "publication_count": 31, "publication_id_list": "10191086;12426236;16641094;16735444;17229678;17475819;18606813;19357255;19367412;20864687;21183079;21209006;22212389;24652796;24700872;26310817;27694161;27892464;28228402;29212817;29354070;29718707;30797506;30901874;31605441;32164329;32340354;32799672;32929357;33332450;34978750", "class_list": "", "function": "Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:10191086). Plays an essential role in renal water homeostasis (PubMed:16641094). Could also be permeable to glycerol (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCG5;Q9R232", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030165 PDZ domain binding;GO:0005372 water transmembrane transporter activity;GO:0015168 glycerol transmembrane transporter activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0007015 actin filament organization;GO:0051289 protein homotetramerization;GO:0006884 cell volume homeostasis;GO:0003097 renal water transport", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P56402-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05020-1", "uniprot_id": [ { "id": "APOC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05020", "type": "external" } ], "mass": 10741.0, "length": 97, "protein_name": "Apolipoprotein C-II", "gene_name": "Apoc2", "organism": "Mouse", "refseq_name": "apolipoprotein C-II precursor", "refseq_ac": [ { "id": "NP_001264873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264873", "type": "external" } ], "gene_names_uniprotkb": "Apoc2", "gene_names_refseq": "Apoc2; apo-CII; apoC-II", "protein_names_uniprotkb": "Apolipoprotein C-II; Apo-CII; ApoC-II; Apolipoprotein C2", "protein_names_refseq": "apolipoprotein C-II precursor; apolipoprotein C-II", "tax_id": 10090, "disease": "familial apolipoprotein C-II deficiency (Disease Ontology:DOID:0111418); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); hypobetalipoproteinemia (Disease Ontology:DOID:1390); multiple sclerosis (Disease Ontology:DOID:2377); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:105886299); (mmu:11813); (R-MMU-8963888); (R-MMU-8963901); (R-MMU-8964058); (R-MMU-975634)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "26574515;28011936;31219806;34428180;35822049;7691714;7916738", "class_list": "", "function": "A novel mouse model of apoC-II deficiency was created with an apoC-II peptide that reverses the hypertriglyceridemia., [RefSeq, PubMed]; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0055102 lipase inhibitor activity;GO:0060230 lipoprotein lipase activator activity;GO:0016004 phospholipase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0034363 intermediate-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0010898 positive regulation of triglyceride catabolic process;GO:0033700 phospholipid efflux;GO:0042953 lipoprotein transport;GO:0016042 lipid catabolic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA57-1", "uniprot_id": [ { "id": "ASPH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2TA57", "type": "external" } ], "mass": 38266.0, "length": 360, "protein_name": "Aspartate beta-hydroxylase domain-containing protein 1", "gene_name": "Asphd1", "organism": "Mouse", "refseq_name": "aspartate beta-hydroxylase domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001034734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034734", "type": "external" } ], "gene_names_uniprotkb": "Asphd1", "gene_names_refseq": "A830007L07Rik; Asphd1; Gm168", "protein_names_uniprotkb": "Aspartate beta-hydroxylase domain-containing protein 1; 1.14.11.-", "protein_names_refseq": "aspartate beta-hydroxylase domain-containing protein 1 isoform 2; aspartate beta-hydroxylase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233879)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TPE9-1", "uniprot_id": [ { "id": "ANKY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TPE9", "type": "external" } ], "mass": 48774.0, "length": 440, "protein_name": "Ankyrin repeat and MYND domain-containing protein 2", "gene_name": "Ankmy2", "organism": "Mouse", "refseq_name": "ankyrin repeat and MYND domain-containing protein 2", "refseq_ac": [ { "id": "NP_666145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666145", "type": "external" } ], "gene_names_uniprotkb": "Ankmy2", "gene_names_refseq": "Ankmy2; ZMYND20", "protein_names_uniprotkb": "Ankyrin repeat and MYND domain-containing protein 2", "protein_names_refseq": "ankyrin repeat and MYND domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217473)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21124868;22872234;25077969;31219806;32702291;34428180", "class_list": "", "function": "Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling., [RefSeq, PubMed]; May be involved in the trafficking of signaling proteins to the cilia., [UniProtKB]; Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK14;Q8BYW5;Q8R3N4;Q921J1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TPE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U128-1", "uniprot_id": [ { "id": "APCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U128", "type": "external" } ], "mass": 58638.0, "length": 514, "protein_name": "Protein APCDD1", "gene_name": "Apcdd1", "organism": "Mouse", "refseq_name": "protein APCDD1 precursor", "refseq_ac": [ { "id": "NP_573500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573500", "type": "external" } ], "gene_names_uniprotkb": "Apcdd1; Drapc1", "gene_names_refseq": "Apcdd1; Drapc1; EIG180", "protein_names_uniprotkb": "Protein APCDD1; Adenomatosis polyposis coli down-regulated 1 protein homolog", "protein_names_refseq": "adenomatosis polyposis coli down-regulated 1 protein homolog; ethanol induced gene product EIG180; protein APCDD1 precursor; protein APCDD1", "tax_id": 10090, "disease": "hypotrichosis 1 (Disease Ontology:DOID:0110698)", "pathway": " (mmu:494504)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15465500;21750661;25428506", "class_list": "", "function": "Mouse Drapc1 is a novel in vivo target gene of Wnt/beta-catenin signaling pathway, [RefSeq, PubMed]; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RUN4;Q3TA99", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0001942 hair follicle development;GO:0030178 negative regulation of Wnt signaling pathway;GO:0043615 astrocyte cell migration;GO:0042487 regulation of odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U128-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URY6-1", "uniprot_id": [ { "id": "ARMC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URY6", "type": "external" } ], "mass": 95311.0, "length": 854, "protein_name": "Armadillo repeat-containing protein 2", "gene_name": "Armc2", "organism": "Mouse", "refseq_name": "armadillo repeat-containing protein 2", "refseq_ac": [ { "id": "NP_001030030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030030", "type": "external" } ], "gene_names_uniprotkb": "Armc2", "gene_names_refseq": "2610018I05Rik; Armc2", "protein_names_uniprotkb": "Armadillo repeat-containing protein 2", "protein_names_refseq": "armadillo repeat-containing protein 2", "tax_id": 10090, "disease": "spermatogenic failure 38 (Disease Ontology:DOID:0111919); male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:213402)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30686508;34428180;8889548", "class_list": "", "function": "Bi-allelic mutations in ARMC2 cause male infertility in humans and mice by inducing a typical 'multiple morphological abnormalities of the flagella' phenotype, indicating that this gene is necessary for sperm flagellum structure and assembly, [RefSeq, PubMed]; Required for sperm flagellum axoneme organization and function (PubMed:30686508). Involved in axonemal central pair complex assembly and/or stability (PubMed:30686508)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0044782 cilium organization;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3URY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q400C8-1", "uniprot_id": [ { "id": "AMZ2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q400C8", "type": "external" } ], "mass": 41341.0, "length": 359, "protein_name": "Archaemetzincin-2", "gene_name": "Amz2", "organism": "Mouse", "refseq_name": "archaemetzincin-2", "refseq_ac": [ { "id": "NP_001239122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239122", "type": "external" } ], "gene_names_uniprotkb": "Amz2", "gene_names_refseq": "Amz2; ESTM12", "protein_names_uniprotkb": "Archaemetzincin-2; 3.4.-.-; Archeobacterial metalloproteinase-like protein 2", "protein_names_refseq": "archaemetzincin-2; archeobacterial metalloproteinase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13929)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15972818;17074343;21750661", "class_list": "", "function": "Probable zinc metalloprotease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVM5;Q8K3B9;Q9D121", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q400C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61268-1", "uniprot_id": [ { "id": "APOC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61268", "type": "external" } ], "mass": 14288.0, "length": 124, "protein_name": "Apolipoprotein C-IV", "gene_name": "Apoc4", "organism": "Mouse", "refseq_name": "apolipoprotein C-IV precursor", "refseq_ac": [ { "id": "NP_031411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031411", "type": "external" } ], "gene_names_uniprotkb": "Apoc4; Acl", "gene_names_refseq": "Acl; Apoc4; apo-CIV; apoC-IV", "protein_names_uniprotkb": "Apolipoprotein C-IV; ACL; Apo-CIV; ApoC-IV; Apolipoprotein C2-linked; Apolipoprotein C4", "protein_names_refseq": "apolipoprotein C-IV precursor; apolipoprotein C2-linked; apolipoprotein C4", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:11425); (R-MMU-8866423); (R-MMU-8964046)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12032151;8088778", "class_list": "", "function": "May participate in lipoprotein metabolism., [UniProtKB]; Regulated exprsesion of gene cluster in macrophages, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0070328 triglyceride homeostasis;GO:0019915 lipid storage", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61268-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640N2-1", "uniprot_id": [ { "id": "AR13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640N2", "type": "external" } ], "mass": 48144.0, "length": 427, "protein_name": "ADP-ribosylation factor-like protein 13B", "gene_name": "Arl13b", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 13B", "refseq_ac": [ { "id": "NP_080853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080853", "type": "external" } ], "gene_names_uniprotkb": "Arl13b; Arl2l1", "gene_names_refseq": "A530097K21Rik; A930014M17Rik; Arl13b; Arl2l1; C530009C10Rik; hnn", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; ARL2-like protein 1; Protein hennin", "protein_names_refseq": "ADP-ribosylation factor-like 2-like 1; ADP-ribosylation factor-like protein 13B; ARL2-like protein 1; protein hennin", "tax_id": 10090, "disease": "Joubert syndrome 8 (Disease Ontology:DOID:0111003)", "pathway": " (mmu:68146); (R-MMU-5624958); (R-MMU-9013406); (R-MMU-9646399)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "17488627;19144319;20231383;20643351;21183079;21539826;21750661;21976698;22554696;22645316;23014696;23153492;23817546;24120134;24339792;25138100;25428506;26582389", "class_list": "", "function": "Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling (PubMed:23817546). Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex (PubMed:23153492). Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (By similarity). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3X9K5", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0001822 kidney development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping;GO:0070986 left/right axis specification", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q640N2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3A9-1", "uniprot_id": [ { "id": "ARL11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P3A9", "type": "external" } ], "mass": 19212.0, "length": 176, "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "Arl11", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 11", "refseq_ac": [ { "id": "NP_796311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796311", "type": "external" } ], "gene_names_uniprotkb": "Arl11", "gene_names_refseq": "ARLTS1; Arl11; C730007L20Rik", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 11", "protein_names_refseq": "ADP-ribosylation factor-like protein 11; ADP-ribosylation factor-like tumor suppressor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:219144)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26740625;31219806", "class_list": "", "function": "May play a role in apoptosis. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7K1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P3A9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75UR0-1", "uniprot_id": [ { "id": "ANO5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q75UR0", "type": "external" } ], "mass": 106214.0, "length": 904, "protein_name": "Anoctamin-5", "gene_name": "Ano5", "organism": "Mouse", "refseq_name": "anoctamin-5 isoform 2", "refseq_ac": [ { "id": "NP_001258808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258808", "type": "external" } ], "gene_names_uniprotkb": "Ano5; Gdd1; Tmem16e", "gene_names_refseq": "9330162L24; Ano5; Gdd1; Tmem16e", "protein_names_uniprotkb": "Anoctamin-5; Gnathodiaphyseal dysplasia 1 protein homolog; Transmembrane protein 16E", "protein_names_refseq": "anoctamin-5 isoform 2; gnathodiaphyseal dysplasia 1 protein homolog; integral membrane protein GDD1; transmembrane protein 16E", "tax_id": 10090, "disease": "Miyoshi muscular dystrophy 3 (Disease Ontology:DOID:0070201); autosomal recessive limb-girdle muscular dystrophy type 2L (Disease Ontology:DOID:0110284); isolated elevated serum creatine phosphokinase levels (Disease Ontology:DOID:0111338); gnathodiaphyseal dysplasia (Disease Ontology:DOID:0111533)", "pathway": " (mmu:233246); (R-MMU-2672351); (R-MMU-9769739)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15124103;15882990;17418107;20056604;20173027;22302790;30084848;33109704;33496727;34428180;36951953;36989132", "class_list": "", "function": "Characterized the complete cDNA sequence and genomic organization of the mouse GDD1 gene, [RefSeq, PubMed]; Genetic disruption of Ano5 leads to impaired osteoclastogenesis for gnathodiaphyseal dysplasia., [RefSeq, PubMed]; Plays a role in plasma membrane repair in a process involving annexins (PubMed:33496727). Does not exhibit calcium-activated chloride channel (CaCC) activity., [UniProtKB, UniProtKB, PubMed]; TMEM16E regulates endothelial cell procoagulant activity and thrombosis. Publication Status: Online-Only, [RefSeq, PubMed]; These observations suggest diverse cellular role(s) of GDD1 in the development of musculoskeletal system., [RefSeq, PubMed]; This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. Elevated levels of this protein were found in dystrophic mice. In humans, mutations of this gene are associated with with musculoskeletal disorders such as myopathies, muscular dystrophy and gnathodiaphyseal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q2VPA8;Q3V657;Q8CC04", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031982 vesicle", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0045332 phospholipid translocation;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q75UR0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZU0-1", "uniprot_id": [ { "id": "ARL5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZU0", "type": "external" } ], "mass": 20724.0, "length": 179, "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "Arl5a", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 5A", "refseq_ac": [ { "id": "NP_892039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892039", "type": "external" } ], "gene_names_uniprotkb": "Arl5a; Arl5", "gene_names_refseq": "2410015N24Rik; 2810410P22Rik; Arl5a; Arl5", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 5A", "protein_names_refseq": "ADP-ribosylation factor-like 5; ADP-ribosylation factor-like protein 5A", "tax_id": 10090, "disease": "", "pathway": " (mmu:75423)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lacks ADP-ribosylation enhancing activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80ZU0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810B6-1", "uniprot_id": [ { "id": "ANFY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810B6", "type": "external" } ], "mass": 128653.0, "length": 1169, "protein_name": "Ankyrin repeat and FYVE domain-containing protein 1", "gene_name": "Ankfy1", "organism": "Mouse", "refseq_name": "ankyrin repeat and FYVE domain-containing protein 1", "refseq_ac": [ { "id": "NP_033801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033801", "type": "external" } ], "gene_names_uniprotkb": "Ankfy1; Ankhzn; Kiaa1255", "gene_names_refseq": "Ankfy1; Ankhzn; ZFYVE14; mKIAA1255", "protein_names_uniprotkb": "Ankyrin repeat and FYVE domain-containing protein 1; Ankyrin repeats hooked to a zinc finger motif; Rab5-binding and ankyrin repeats-containing protein; Rabankyrin-5; Rank-5", "protein_names_refseq": "Rabankyrin-5; ankyrin repeat and FYVE domain-containing protein 1; ankyrin repeat hooked to a zinc finger motif; ankyrin repeat hooked to zinc finger motif; ankyrin repeats hooked to a zinc finger motif; rab5-binding and ankyrin repeats-containing protein; rank-5", "tax_id": 10090, "disease": "Charlevoix-Saguenay spastic ataxia (Disease Ontology:DOID:0050946)", "pathway": " (mmu:11736)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10092534;15328530;34428180;37828378;39627609", "class_list": "", "function": "Proposed effector of Rab5 (By similarity). Binds to phosphatidylinositol 3-phosphate (PI[3]P) (By similarity). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with early endosomes (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP (PubMed:15328530). Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB (By similarity). Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner (By similarity). Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Required for podocyte migration (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ATS3;O54807;Q80TG6;Q80UH8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0034058 endosomal vesicle fusion;GO:0042147 retrograde transport, endosome to Golgi;GO:0048549 positive regulation of pinocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q810B6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH07-1", "uniprot_id": [ { "id": "AR6P6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH07", "type": "external" } ], "mass": 24909.0, "length": 226, "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "gene_name": "Arl6ip6", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "refseq_ac": [ { "id": "NP_075365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075365", "type": "external" } ], "gene_names_uniprotkb": "Arl6ip6", "gene_names_refseq": "2310057C01Rik; 2610529A11Rik; Aip-6; Arl6ip6", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6-interacting protein 6; ARL-6-interacting protein 6; Aip-6", "protein_names_refseq": "ADP-ribosylation factor-like protein 6-interacting protein 6; ADP-ribosylation-like factor 6 interacting protein 6; ARL-6-interacting protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:65103)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10508919;16325184;19144319;31142202", "class_list": "", "function": "ADP-ribosylation factor 6 negatively regulates dendritic spine formation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSK7;Q8VCL3;Q9CY07;Q9D4R5;Q9WUH0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BH07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM75-1", "uniprot_id": [ { "id": "ARI5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM75", "type": "external" } ], "mass": 131837.0, "length": 1188, "protein_name": "AT-rich interactive domain-containing protein 5B", "gene_name": "Arid5b", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 5B", "refseq_ac": [ { "id": "NP_076087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076087", "type": "external" } ], "gene_names_uniprotkb": "Arid5b; Desrt; Mrf2", "gene_names_refseq": "4930580B11; 5430435G07Rik; Arid5b; Desrt; Mrf2alpha; Mrf2beta; Mrf2", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 5B; ARID domain-containing protein 5B; Desrt; Developmentally and sexually retarded with transient immune abnormalities protein; MRF-2; MRF1-like; Modulator recognition factor protein 2", "protein_names_refseq": "ARID class DNA binding protein; ARID domain-containing protein 5B; AT rich interactive domain 5B (MRF1-like); AT rich interactive domain 5B (Mrf1 like); AT-rich interactive domain-containing protein 5B; MRF-2; developmentally and sexually retarded with transient immune abnormalities protein; modulator recognition factor 2; modulator recognition factor protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71371); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;11404092;11483573;12215486;14651970;17962384;18070594;19913508;21750661;25428506;30084848;30779550;31219806;31599954;33757861;34428180;35924577;36210013;36743919;36852467;37483604;40997131", "class_list": "", "function": "ARID5B influences B-cell development and function in mouse. Publication Status: Online-Only, [RefSeq, PubMed]; ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development. Publication Status: Online-Only, [RefSeq, PubMed]; Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis., [RefSeq, PubMed]; Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9Q523;Q8C0E0;Q8K4G8;Q8K4L9;Q9CU78;Q9JIX4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:1902494 catalytic complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060612 adipose tissue development;GO:0001822 kidney development;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8BM75-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3A9-1", "uniprot_id": [ { "id": "MEPCE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3A9", "type": "external" } ], "mass": 72050.0, "length": 666, "protein_name": "7SK snRNA methylphosphate capping enzyme", "gene_name": "Mepce", "organism": "Mouse", "refseq_name": "7SK snRNA methylphosphate capping enzyme isoform 1", "refseq_ac": [ { "id": "NP_659162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659162", "type": "external" } ], "gene_names_uniprotkb": "Mepce; Bcdin3; Bipl1; D5Wsu46e", "gene_names_refseq": "Bcdin3; D5Wsu46e; Mepce", "protein_names_uniprotkb": "7SK snRNA methylphosphate capping enzyme; 2.1.1.-; MePCE", "protein_names_refseq": "7SK snRNA methylphosphate capping enzyme isoform 1; 7SK snRNA methylphosphate capping enzyme; bin3, bicoid-interacting 3, homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:231803)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16926269;17242355;21183079;21750661;23154982;24129315;25153642;28135057;28528544;31219806", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (By similarity). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:23154982). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (By similarity). MEPCE has a non-enzymatic function in the 7SK RNP complex; it has a non-enzymatic function; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (By similarity). Also required for stability of U6 snRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2YFS5;Q3U465;Q3UT64;Q91W35", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008171 O-methyltransferase activity;GO:0017069 snRNA binding;GO:0097322 7SK snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:1990904 ribonucleoprotein complex;GO:0120259 7SK snRNP", "go_biological_process": "GO:1904871 positive regulation of protein localization to Cajal body;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0001510 RNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K3A9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47879-1", "uniprot_id": [ { "id": "IBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P47879", "type": "external" } ], "mass": 27807.0, "length": 254, "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "Igfbp4", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 4 precursor", "refseq_ac": [ { "id": "NP_034647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034647", "type": "external" } ], "gene_names_uniprotkb": "Igfbp4; Igfbp-4", "gene_names_refseq": "Deb2; IBP-4; IGFBP-4; Igfbp4", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4", "protein_names_refseq": "Band 3A; IGF-binding protein 4; differentially expressed in B16F10 2; insulin-like growth factor-binding protein 4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:16010); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;25428506;37349627;37433992;7529732;7531538;9468222", "class_list": "", "function": "Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma., [RefSeq, PubMed]; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB]; The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35666;Q3TMV0", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0040008 regulation of growth;GO:0043410 positive regulation of MAPK cascade;GO:0010906 regulation of glucose metabolic process;GO:0001558 regulation of cell growth;GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47879-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIP4-1", "uniprot_id": [ { "id": "PANX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIP4", "type": "external" } ], "mass": 48167.0, "length": 426, "protein_name": "Pannexin-1", "gene_name": "Panx1", "organism": "Mouse", "refseq_name": "pannexin-1", "refseq_ac": [ { "id": "NP_062355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062355", "type": "external" } ], "gene_names_uniprotkb": "Panx1", "gene_names_refseq": "Panx1", "protein_names_uniprotkb": "Pannexin-1", "protein_names_refseq": "pannexin-1", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:55991); (R-MMU-112303); (R-MMU-844456)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10898987;14597722;15661370;16026466;17925379;21750661;22311122;23033481;26242575;30814251;32238926;35563450", "class_list": "", "function": "During apoptosis and after cleavage by caspases of the C-terminal tail, acts as a plasma membrane channel which mediates the regulated release of find-me signals, such as nucleotides ATP and UTP, and selective plasme membrane permeability., [UniProtKB, PubMed]; Expression of pannexin1 in the hippocampus and inferior olive., [RefSeq, PubMed]; Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:30814251). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (PubMed:22311122). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The Panx1 expresses in the brain, retina and other non-neuronal tissues. In the cortex, cerebellum and eye, Panx1 is expressed at early embryonic time points and peaks around embryonic day 18 followed by a decline towards adulthood., [RefSeq, PubMed]; The different expression patterns of Px1 and Px2 in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions [pannexin 2], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL18;Q9CXS7", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032059 bleb;GO:0005921 gap junction", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0098656 monoatomic anion transmembrane transport;GO:0002931 response to ischemia;GO:0007267 cell-cell signaling;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JIP4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3U1-1", "uniprot_id": [ { "id": "PLAT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3U1", "type": "external" } ], "mass": 17872.0, "length": 162, "protein_name": "Phospholipase A and acyltransferase 3", "gene_name": "Plaat3", "organism": "Mouse", "refseq_name": "phospholipase A and acyltransferase 3 isoform 1", "refseq_ac": [ { "id": "NP_644675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_644675", "type": "external" } ], "gene_names_uniprotkb": "Plaat3; H-rev107; Hrasls3; Hrev107; Pla2g16", "gene_names_refseq": "AdPLA; HRSL3; Hrasls3; Hrev107; MLP-3; Pla2g16; Plaat3", "protein_names_uniprotkb": "Phospholipase A and acyltransferase 3; 2.3.1.-; 3.1.1.32; 3.1.1.4; AdPLA; Adipose-specific phospholipase A2; Group XVI phospholipase A2; H-rev 107 protein homolog; HRAS-like suppressor 3; HRSL3", "protein_names_refseq": "H-rev 107 protein homolog; HRAS-like suppressor 3; LRAT-like protein 3; adipose-specific phospholipase A2; group XVI phospholipase A1/A2; group XVI phospholipase A2; phospholipase A and acyltransferase 3 isoform 1; phospholipase A2, group XVI", "tax_id": 10090, "disease": "seminoma (Disease Ontology:DOID:4440)", "pathway": " (mmu:225845); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12054540;12055182;18614531;18664718;19047760;19136964;21750661;22134920;28077878;32853041;33854238;35820727;37919452", "class_list": "", "function": "(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878)., [UniProtKB, PubMed]; Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760, PubMed:37919452). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:18614531, PubMed:19047760, PubMed:19136964, PubMed:22134920). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity,catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (PubMed:33854238). Organelle membrane degradation is probably catalyzed by the phospholipase activity (PubMed:33854238)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; HRASLS3 as one of the downstream effectors of PPARgamma action in adipogenesis., [RefSeq, PubMed]; Identification of an Sp1/Sp3-binding GC-box required for the transcription of H-rev107 (H-rev107), [RefSeq, PubMed]; Organelle degradation in the lens by PLAAT phospholipases., [RefSeq, PubMed]; Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease., [RefSeq, PubMed]; Study found that AdPLA that was previously known as H-Rev-107/HRASLS3 is an adipose-specific, calcium-dependent histidine PLA2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7X6T3;Q3V3C3;Q8BWF7", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0008289 lipid binding;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:1903008 organelle disassembly;GO:0006641 triglyceride metabolic process;GO:0007031 peroxisome organization;GO:0016042 lipid catabolic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R3U1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63001-1", "uniprot_id": [ { "id": "RAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63001", "type": "external" } ], "mass": 21450.0, "length": 192, "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "Rac1", "organism": "Mouse", "refseq_name": "ras-related C3 botulinum toxin substrate 1 isoform 2", "refseq_ac": [ { "id": "NP_033033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033033", "type": "external" } ], "gene_names_uniprotkb": "Rac1", "gene_names_refseq": "D5Ertd559e; Rac1", "protein_names_uniprotkb": "Ras-related C3 botulinum toxin substrate 1; 3.6.5.2; p21-Rac1", "protein_names_refseq": "RAS-related C3 botulinum substrate 1; p21-Rac1; ras-related C3 botulinum toxin substrate 1 isoform 2; ras-related C3 botulinum toxin substrate 1", "tax_id": 10090, "disease": "colon adenoma (Disease Ontology:DOID:0050912); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal dominant intellectual developmental disorder 48 (Disease Ontology:DOID:0080235); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); gastric adenocarcinoma (Disease Ontology:DOID:3717); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); gallbladder carcinoma (Disease Ontology:DOID:4948); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:19353); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-193648); (R-MMU-2029482); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-389359); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665); (R-MMU-399954); (R-MMU-4086400); (R-MMU-416550); (R-MMU-418885); (R-MMU-4420097); (R-MMU-445144); (R-MMU-5218920); (R-MMU-5625740); (R-MMU-5625900); (R-MMU-5625970); (R-MMU-5626467); (R-MMU-5627123); (R-MMU-5663213); (R-MMU-5663220); (R-MMU-5668599); (R-MMU-5687128); (R-MMU-6798695); (R-MMU-6811558); (R-MMU-8849471); (R-MMU-8875555); (R-MMU-9013149); (R-MMU-9032759); (R-MMU-9748787); (R-MMU-983231); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 38, "publication_count": 27, "publication_id_list": "10679324;10934474;10934475;12695502;14634666;16002401;17116687;17403031;19007770;19029984;1905006;19737524;20696765;20974804;22959435;23512198;23963642;24352656;26663135;26969129;31068775;33250856;33300544;34428180;37453647;39927985;9707409", "class_list": "", "function": "Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:24352656). In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:24352656, PubMed:26969129). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). Required for DSG3 translocation to cell-cell junctions, DSG3-mediated organization of cortical F-actin bundles and anchoring of actin at cell junctions; via interaction with DSG3 (By similarity). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O95501;P15154;Q9BTB4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0001891 phagocytic cup", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0010762 regulation of fibroblast migration;GO:0021799 cerebral cortex radially oriented cell migration;GO:2000386 positive regulation of ovarian follicle development;GO:0046425 regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P63001-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVM6-1", "uniprot_id": [ { "id": "TLL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVM6", "type": "external" } ], "mass": 113252.0, "length": 1012, "protein_name": "Tolloid-like protein 2", "gene_name": "Tll2", "organism": "Mouse", "refseq_name": "tolloid-like protein 2 precursor", "refseq_ac": [ { "id": "NP_036034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036034", "type": "external" } ], "gene_names_uniprotkb": "Tll2", "gene_names_refseq": "Tll2", "protein_names_uniprotkb": "Tolloid-like protein 2; 3.4.24.-", "protein_names_refseq": "tolloid-like protein 2 precursor; tolloid-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:24087); (R-MMU-1650814); (R-MMU-2214320); (R-MMU-2243919)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10479448;11313359;18286185;21750661;24129315", "class_list": "", "function": "Loss-of-function mutation in Tll2, has a small, but significant, effect on muscle mass Publication Status: Online-Only, [RefSeq, PubMed]; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2RTK3", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0009953 dorsal/ventral pattern formation;GO:0048632 negative regulation of skeletal muscle tissue growth;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVM6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27467-1", "uniprot_id": [ { "id": "WNT3A_MOUSE", "url": "https://www.uniprot.org/uniprot/P27467", "type": "external" } ], "mass": 39258.0, "length": 352, "protein_name": "Protein Wnt-3a", "gene_name": "Wnt3a", "organism": "Mouse", "refseq_name": "protein Wnt-3a precursor", "refseq_ac": [ { "id": "NP_033548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033548", "type": "external" } ], "gene_names_uniprotkb": "Wnt3a; Wnt-3a", "gene_names_refseq": "Wnt-3a; Wnt3a; vt", "protein_names_uniprotkb": "Protein Wnt-3a", "protein_names_refseq": "protein Wnt-3a precursor; protein Wnt-3a; vestigial tail; wingless-related MMTV integration site 3A", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:22416); (R-MMU-201681); (R-MMU-3238698); (R-MMU-4641262); (R-MMU-4641263); (R-MMU-9856649)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10866835;12717451;17141155;2001840;22726442;24798332;25771893;26902720;8299937", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0050770 regulation of axonogenesis;GO:0048343 paraxial mesodermal cell fate commitment;GO:2001141 regulation of RNA biosynthetic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P27467-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21845-1", "uniprot_id": [ { "id": "TRYB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P21845", "type": "external" } ], "mass": 30927.0, "length": 276, "protein_name": "Tryptase beta-2", "gene_name": "Tpsb2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpsb2; Mcpt6", "gene_names_refseq": "", "protein_names_uniprotkb": "Tryptase beta-2; 3.4.21.59; Mast cell protease 6; Tryptase-2; mMCP-6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17229); (R-MMU-1592389)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16777228;17456473;17947660;1995638;21750661;2326280;7959952;8210998", "class_list": "", "function": "Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61962", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:1905368 peptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21845-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAD6-1", "uniprot_id": [ { "id": "PROF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAD6", "type": "external" } ], "mass": 14697.0, "length": 137, "protein_name": "Profilin-3", "gene_name": "Pfn3", "organism": "Mouse", "refseq_name": "profilin-3", "refseq_ac": [ { "id": "NP_083579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083579", "type": "external" } ], "gene_names_uniprotkb": "Pfn3", "gene_names_refseq": "1700012P12Rik; Pfn3", "protein_names_uniprotkb": "Profilin-3; Profilin III", "protein_names_refseq": "profilin III; profilin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:75477)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11867228;18692047", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis., [UniProtKB]; These findings suggest that the testis-specific profilin III-ArpM1 complex may be involved in conformational changes in the organization of the sperm-specific nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQJ9-1", "uniprot_id": [ { "id": "MAGI3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQJ9", "type": "external" } ], "mass": 161672.0, "length": 1476, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3", "gene_name": "Magi3", "organism": "Mouse", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 2", "refseq_ac": [ { "id": "NP_598614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598614", "type": "external" } ], "gene_names_uniprotkb": "Magi3; Kiaa1634", "gene_names_refseq": "4732496O19Rik; 6530407C02Rik; Magi3; mKIAA1634", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; MAGI-3; Membrane-associated guanylate kinase inverted 3", "protein_names_refseq": "membrane-associated guanylate kinase inverted 3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related (MAGI-3)", "tax_id": 10090, "disease": "", "pathway": " (mmu:99470)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;14645510;15195140;15509766;15652357;17242355;18299400;21183079;21750661;25428506;30084848;33712709;34428180;34887587;35820727;35864508", "class_list": "", "function": "Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells., [RefSeq, PubMed]; MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0V3N7;B0V3N8;Q69ZE1;Q8C0P8", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0007165 signal transduction;GO:0043507 positive regulation of JUN kinase activity", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9EQJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60754-1", "uniprot_id": [ { "id": "MARCO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60754", "type": "external" } ], "mass": 52730.0, "length": 518, "protein_name": "Macrophage receptor MARCO", "gene_name": "Marco", "organism": "Mouse", "refseq_name": "macrophage receptor MARCO", "refseq_ac": [ { "id": "NP_034896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034896", "type": "external" } ], "gene_names_uniprotkb": "Marco", "gene_names_refseq": "Ly112; Marco; Scara2", "protein_names_uniprotkb": "Macrophage receptor MARCO; Macrophage receptor with collagenous structure", "protein_names_refseq": "macrophage receptor MARCO", "tax_id": 10090, "disease": "meningococcal meningitis (Disease Ontology:DOID:0080176); silicosis (Disease Ontology:DOID:10325); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:17167)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10331948;11820786;17405873;20173027;21750661;26495903;34428180;35820727;38494423;7867067", "class_list": "", "function": "An arginine-rich segment in domain V of MARCO and particularly its RXR motifs play a critical role in high affinity bacterial binding., [RefSeq, PubMed]; Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages., [RefSeq, PubMed]; Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:7867067). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0001664 G protein-coupled receptor binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006911 phagocytosis, engulfment;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0030198 extracellular matrix organization;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60754-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHJ5-1", "uniprot_id": [ { "id": "MARK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHJ5", "type": "external" } ], "mass": 88335.0, "length": 795, "protein_name": "Serine/threonine-protein kinase MARK1", "gene_name": "Mark1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase MARK1 isoform 2", "refseq_ac": [ { "id": "NP_663490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663490", "type": "external" } ], "gene_names_uniprotkb": "Mark1; Emk3; Kiaa1477", "gene_names_refseq": "B930025N23Rik; Emk3; Mark1; Par-1c; mKIAA1477; mPar-1c", "protein_names_uniprotkb": "Serine/threonine-protein kinase MARK1; 2.7.11.1; 2.7.11.26; ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; mPar-1c", "protein_names_refseq": "ELKL motif serine-threonine protein kinase 3; PAR1 homolog c; serine/threonine-protein kinase MARK1 isoform 2; serine/threonine-protein kinase MARK1", "tax_id": 10090, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:226778)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16452087;21183079;21750661;22645316;25428506;30016717;30084848;30779550;31719161;33300544;34428180;38484863", "class_list": "", "function": "MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo., [RefSeq, PubMed]; Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)., [UniProtKB, UniProtKB]; The results suggest that Mark1-mediated fibroblast activation induces AECI flattening and thereby regulates distal lung sacculation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QL17;Q69ZI7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8VHJ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97310-1", "uniprot_id": [ { "id": "MCM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97310", "type": "external" } ], "mass": 102078.0, "length": 904, "protein_name": "DNA replication licensing factor MCM2", "gene_name": "Mcm2", "organism": "Mouse", "refseq_name": "DNA replication licensing factor MCM2", "refseq_ac": [ { "id": "NP_032590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032590", "type": "external" } ], "gene_names_uniprotkb": "Mcm2; Bm28; Cdcl1; Kiaa0030; Mcmd2", "gene_names_refseq": "BM28; CDCL1; Mcm2; Mcmd2; mKIAA0030", "protein_names_uniprotkb": "DNA replication licensing factor MCM2; 3.6.4.12; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28", "protein_names_refseq": "DNA replication licensing factor MCM2; mini chromosome maintenance deficient 2; minichromosome maintenance deficient 2 mitotin; minichromosome maintenance protein 2 homolog; nuclear protein BM28", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 70 (Disease Ontology:DOID:0110592); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:17216); (R-MMU-176187); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10517317;10567526;11278932;15345747;17242355;17622165;19131326;21183079;21750661;29562282;31219806;34428180;36807739;37828378;39627609;9077461;9371513;9798653", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division (PubMed:10567526). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08971;O89057;Q8C2R0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006915 apoptotic process;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0071353 cellular response to interleukin-4;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P97310-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KAU4-1", "uniprot_id": [ { "id": "MB12B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6KAU4", "type": "external" } ], "mass": 35411.0, "length": 317, "protein_name": "Multivesicular body subunit 12B", "gene_name": "Mvb12b", "organism": "Mouse", "refseq_name": "multivesicular body subunit 12B", "refseq_ac": [ { "id": "NP_780393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780393", "type": "external" } ], "gene_names_uniprotkb": "Mvb12b; Fam125b", "gene_names_refseq": "2610200O14Rik; 2610528K11Rik; Fam125b; Mvb12b", "protein_names_uniprotkb": "Multivesicular body subunit 12B; ESCRT-I complex subunit MVB12B; Protein FAM125B", "protein_names_refseq": "ESCRT-I complex subunit MVB12B; family with sequence similarity 125, member B; multivesicular body subunit 12B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72543); (R-MMU-917729)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;21750661;30084848;30779550;30804548;34428180;35820727", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Multivesicular body protein MVB12b is a target for TANK-binding kinase 1 phosphorylation, which is essential for the sorting of DNA into extracellular vesicles and stimulation of bystander cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ARF1;Q6PB42", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0042058 regulation of epidermal growth factor receptor signaling pathway;GO:0046755 viral budding;GO:0019075 virus maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6KAU4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FW53-1", "uniprot_id": [ { "id": "MBPHL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FW53", "type": "external" } ], "mass": 38760.0, "length": 355, "protein_name": "Myosin-binding protein H-like", "gene_name": "Mybphl", "organism": "Mouse", "refseq_name": "myosin-binding protein H-like", "refseq_ac": [ { "id": "NP_081107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081107", "type": "external" } ], "gene_names_uniprotkb": "Mybphl", "gene_names_refseq": "1110037P11Rik; Mybphl", "protein_names_uniprotkb": "Myosin-binding protein H-like", "protein_names_refseq": "myosin-binding protein H-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:68753)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24129315;28778945;34428180;35533732", "class_list": "", "function": "Myosin-binding protein which plays a role in cardiac function (PubMed:28778945). Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945)., [UniProtKB, PubMed]; Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects., [RefSeq, PubMed]; Report reduced ventricular function and conduction system defects in Mybphl knockout mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030017 sarcomere;GO:0036379 myofilament", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5FW53-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NSQ7-1", "uniprot_id": [ { "id": "LTV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NSQ7", "type": "external" } ], "mass": 54023.0, "length": 470, "protein_name": "Protein LTV1 homolog", "gene_name": "Ltv1", "organism": "Mouse", "refseq_name": "protein LTV1 homolog", "refseq_ac": [ { "id": "NP_852135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852135", "type": "external" } ], "gene_names_uniprotkb": "Ltv1", "gene_names_refseq": "2610020N02Rik; Ltv1", "protein_names_uniprotkb": "Protein LTV1 homolog", "protein_names_refseq": "LTV1 homolog; protein LTV1 homolog", "tax_id": 10090, "disease": "inflammatory poikiloderma with hair abnormalities and acral keratoses (Disease Ontology:DOID:0070510)", "pathway": " (mmu:353258); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;25153642;25428506;28528544;30779550;31219806;34428180", "class_list": "", "function": "Essential for ribosome biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0F5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000056 ribosomal small subunit export from nucleus;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6NSQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ34-1", "uniprot_id": [ { "id": "MARF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ34", "type": "external" } ], "mass": 192064.0, "length": 1730, "protein_name": "Meiosis regulator and mRNA stability factor 1", "gene_name": "Marf1", "organism": "Mouse", "refseq_name": "meiosis regulator and mRNA stability factor 1", "refseq_ac": [ { "id": "NP_001074623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074623", "type": "external" } ], "gene_names_uniprotkb": "Marf1; Kiaa0430; Lkap", "gene_names_refseq": "4921513D23Rik; E030019O05; Lkap; Marf1; mKIAA0430", "protein_names_uniprotkb": "Meiosis regulator and mRNA stability factor 1; Limkain-b1; Meiosis arrest female protein 1", "protein_names_refseq": "limkain-b1; meiosis arrest female 1; meiosis arrest female protein 1; meiosis regulator and mRNA stability factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223989)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17947660;20173027;21183079;21750661;22442484;23090997;25428506;28442784;30333187;31599954;34418053;34428180;35820727", "class_list": "", "function": "Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks., [UniProtKB, PubMed, PubMed]; Here, the authors report that meiosis arrest female 1 (MARF1) is an RBP that is expressed during neuronal differentiation. Cortical neurons expressed the somatic form of MARF1 (sMARF1) but not the oocyte form (oMARF1). sMARF1 was enriched in embryonic brains, and its expression level decreased as brain development progressed. Publication Status: Online-Only, [RefSeq, PubMed]; MARF1 (4921513D23Rik), by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring, [RefSeq, PubMed]; Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes., [RefSeq, PubMed]; Purified MARF1 cleaved ssRNAs in vitro., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPE4;Q5DU29;Q8C6U4;Q8K2E6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004540 RNA nuclease activity;GO:1905762 CCR4-NOT complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006302 double-strand break repair;GO:0007143 female meiotic nuclear division;GO:0010468 regulation of gene expression;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BJ34-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPM2-1", "uniprot_id": [ { "id": "M4K5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPM2", "type": "external" } ], "mass": 95045.0, "length": 847, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 5", "gene_name": "Map4k5", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 5", "refseq_ac": [ { "id": "NP_958927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958927", "type": "external" } ], "gene_names_uniprotkb": "Map4k5", "gene_names_refseq": "4432415E19Rik; GCKR; KHS; MAPKKKK5; Map4k5", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase 5; 2.7.11.1; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5", "protein_names_refseq": "MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5; mitogen-activated protein kinase kinase kinase kinase 5", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:399510)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16914735;17242355;21183079;31219806;34428180", "class_list": "", "function": "Germinal center kinase-related enzyme (GCKR) facilitates both canonical and noncanonical Wnt signaling in B lymphocytes., [RefSeq, PubMed]; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEQ2;Q8C3U5;Q8CGF3;Q99LM7;Q9CX73", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BPM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA11-1", "uniprot_id": [ { "id": "LYZL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA11", "type": "external" } ], "mass": 16818.0, "length": 148, "protein_name": "Lysozyme-like protein 6", "gene_name": "Lyzl6", "organism": "Mouse", "refseq_name": "lysozyme-like protein 6 precursor", "refseq_ac": [ { "id": "NP_081359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081359", "type": "external" } ], "gene_names_uniprotkb": "Lyzl6; Lyc1", "gene_names_refseq": "1700023H08Rik; Lyc1; Lyzb; Lyzl6", "protein_names_uniprotkb": "Lysozyme-like protein 6; 3.2.1.17", "protein_names_refseq": "lysozyme b; lysozyme-like protein 1; lysozyme-like protein 6 precursor; lysozyme-like protein 6", "tax_id": 10090, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:69444)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24013621", "class_list": "glycogene;glycosylhydrolase", "function": "May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566 fertilization;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DA11-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXA7-1", "uniprot_id": [ { "id": "TRI44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXA7", "type": "external" } ], "mass": 38272.0, "length": 346, "protein_name": "Tripartite motif-containing protein 44", "gene_name": "Trim44", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 44", "refseq_ac": [ { "id": "NP_064663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064663", "type": "external" } ], "gene_names_uniprotkb": "Trim44; Dipb", "gene_names_refseq": "Dipb; Mc7; Trim44", "protein_names_uniprotkb": "Tripartite motif-containing protein 44; Protein DIPB; Protein Mc7", "protein_names_refseq": "DIPB; brain cDNA 7; protein Mc7; tripartite motif-containing protein 44", "tax_id": 10090, "disease": "aniridia (Disease Ontology:DOID:12271)", "pathway": " (mmu:80985)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11165382;19358823;21183079;21750661;25428506;30084848;30779550;31219806;34428180;36227676;37119283;38731834", "class_list": "", "function": "Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity)., [UniProtKB, UniProtKB]; TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis., [RefSeq, PubMed]; TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80SV9;Q9JHR8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QXA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04750-1", "uniprot_id": [ { "id": "TOP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04750", "type": "external" } ], "mass": 90876.0, "length": 767, "protein_name": "DNA topoisomerase 1", "gene_name": "Top1", "organism": "Mouse", "refseq_name": "DNA topoisomerase 1 isoform 1", "refseq_ac": [ { "id": "NP_033434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033434", "type": "external" } ], "gene_names_uniprotkb": "Top1; Top-1", "gene_names_refseq": "D130064I21Rik; Top-1; Top1", "protein_names_uniprotkb": "DNA topoisomerase 1; 5.6.2.1; DNA topoisomerase I", "protein_names_refseq": "DNA topoisomerase 1 isoform 1; DNA topoisomerase 1; DNA topoisomerase I", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:21969); (R-MMU-4615885)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17932134;23806337;25428506;30059200;31219806;34428180;37086201;37094168;37833256;39627609;8096488", "class_list": "", "function": "Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase., [RefSeq, PubMed]; Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification., [RefSeq, PubMed]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter., [UniProtKB, UniProtKB]; Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A4B7", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0043204 perikaryon", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007059 chromosome segregation;GO:0010332 response to gamma radiation;GO:0006260 DNA replication;GO:0009266 response to temperature stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q04750-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0B5-1", "uniprot_id": [ { "id": "TSTD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0B5", "type": "external" } ], "mass": 17271.0, "length": 157, "protein_name": "Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3", "gene_name": "Tstd3", "organism": "Mouse", "refseq_name": "thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3", "refseq_ac": [ { "id": "NP_084116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084116", "type": "external" } ], "gene_names_uniprotkb": "Tstd3", "gene_names_refseq": "2610029I01Rik; Tstd3", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3; Rhodanese domain-containing protein 3", "protein_names_refseq": "rhodanese domain-containing protein 3; thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:77032)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23806337;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D0B5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDI2-1", "uniprot_id": [ { "id": "FBX43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDI2", "type": "external" } ], "mass": 71171.0, "length": 640, "protein_name": "F-box only protein 43", "gene_name": "Fbxo43", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fbxo43; Emi2", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box only protein 43; Endogenous meiotic inhibitor 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 64 (Disease Ontology:DOID:0112353)", "pathway": " (mmu:78803)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16456547;21750661;28723571", "class_list": "", "function": "Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:16456547). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis (PubMed:28723571)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G0C8;Q8R0R1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010948 negative regulation of cell cycle process;GO:0016567 protein ubiquitination;GO:0042177 negative regulation of protein catabolic process;GO:0007088 regulation of mitotic nuclear division;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CDI2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88188-1", "uniprot_id": [ { "id": "LY86_MOUSE", "url": "https://www.uniprot.org/uniprot/O88188", "type": "external" } ], "mass": 17811.0, "length": 162, "protein_name": "Lymphocyte antigen 86", "gene_name": "Ly86", "organism": "Mouse", "refseq_name": "lymphocyte antigen 86 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034875", "type": "external" } ], "gene_names_uniprotkb": "Ly86; Md1", "gene_names_refseq": "Ly86; MD-1; MD1; ly86_tv2", "protein_names_uniprotkb": "Lymphocyte antigen 86; Ly-86; Protein MD-1", "protein_names_refseq": "ly-86; lymphocyte antigen 86 isoform 1 precursor; protein MD-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17084); (R-MMU-166016)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10925274;11861286;18250455;20595044;21959264;26495903;27802388;30084848;31219806;33257269;34428180;35984892;37231994;38878954;9686597", "class_list": "", "function": "Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling in Diabetic Cardiomyopathy by Activating the TLR4/NF-kappaB Signalling Pathway., [RefSeq, PubMed]; MD1 Depletion Predisposes to Ventricular Arrhythmias in the Setting of Myocardial Infarction., [RefSeq, PubMed]; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression., [UniProtKB, PubMed]; Overexpression of MD1 ameliorates pathological myocardial remodeling in diabetic cardiomyopathy by TLR4/STAT3 signaling pathway., [RefSeq, PubMed]; Required for cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide . RP105/MD-1 has structural similarity to Toll-like receptor 4(TRL4), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAF1;Q5D046", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O88188-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAE8-1", "uniprot_id": [ { "id": "CA074_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAE8", "type": "external" } ], "mass": 28921.0, "length": 263, "protein_name": "UPF0739 protein C1orf74 homolog", "gene_name": "A130010J15Rik", "organism": "Mouse", "refseq_name": "UPF0739 protein C1orf74 homolog", "refseq_ac": [ { "id": "NP_001153831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153831", "type": "external" } ], "gene_names_uniprotkb": "A130010J15Rik", "gene_names_refseq": "A130010J15Rik", "protein_names_uniprotkb": "UPF0739 protein C1orf74 homolog", "protein_names_refseq": "UPF0739 protein C1orf74 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:319266)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39927985", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97769-1", "uniprot_id": [ { "id": "CITE1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97769", "type": "external" } ], "mass": 20800.0, "length": 203, "protein_name": "Cbp/p300-interacting transactivator 1", "gene_name": "Cited1", "organism": "Mouse", "refseq_name": "cbp/p300-interacting transactivator 1 isoform a", "refseq_ac": [ { "id": "NP_001263395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263395", "type": "external" } ], "gene_names_uniprotkb": "Cited1; Msg1", "gene_names_refseq": "Cited1; Msg1", "protein_names_uniprotkb": "Cbp/p300-interacting transactivator 1; Melanocyte-specific protein 1", "protein_names_refseq": "cbp/p300-interacting transactivator 1 isoform a; cbp/p300-interacting transactivator 1; melanocyte-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12705); (R-MMU-8866907); (R-MMU-9018519)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10722728;11581164;14673158;17938205;18187554;21750661;8901575", "class_list": "", "function": "Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0070410 co-SMAD binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0070669 response to interleukin-2;GO:0071104 response to interleukin-9;GO:0071105 response to interleukin-11", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97769-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFY9-1", "uniprot_id": [ { "id": "CC14B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFY9", "type": "external" } ], "mass": 55661.0, "length": 485, "protein_name": "Dual specificity protein phosphatase CDC14B", "gene_name": "Cdc14b", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase CDC14B isoform 2", "refseq_ac": [ { "id": "NP_001116461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116461", "type": "external" } ], "gene_names_uniprotkb": "Cdc14b", "gene_names_refseq": "2810432N10Rik; A530086E13Rik; CDC14B3; Cdc14B1; Cdc14b", "protein_names_uniprotkb": "Dual specificity protein phosphatase CDC14B; 3.1.3.16; 3.1.3.48; CDC14 cell division cycle 14 homolog B", "protein_names_refseq": "CDC14 cell division cycle 14 homolog B; dual specificity protein phosphatase CDC14B isoform 2; dual specificity protein phosphatase CDC14B", "tax_id": 10090, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:218294); (R-MMU-5687128)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19129509;19923902;21262768;21502810;21750661;22355704;26283732;32341029", "class_list": "", "function": "CDC14B is a negative regulator of meiotic resumption and may regulate meiosis I in mouse oocytes., [RefSeq, PubMed]; CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis., [RefSeq, PubMed]; Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase pathway as a major effector pathway during oncogenic transformation., [RefSeq, PubMed]; Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low., [RefSeq, PubMed]; Cdc14b is required for efficient DNA damage repair., [RefSeq, PubMed]; Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription, [RefSeq, PubMed]; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity)., [UniProtKB]; Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80WC4;Q8BLV5", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0060271 cilium assembly;GO:0006470 protein dephosphorylation;GO:1904668 positive regulation of ubiquitin protein ligase activity;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PFY9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGD0-1", "uniprot_id": [ { "id": "CEP15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGD0", "type": "external" } ], "mass": 14729.0, "length": 127, "protein_name": "Centrosomal protein 15", "gene_name": "Cep15", "organism": "Mouse", "refseq_name": "centrosomal protein 15 isoform 2", "refseq_ac": [ { "id": "NP_001271312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271312", "type": "external" } ], "gene_names_uniprotkb": "Cep15; 3830406C13Rik", "gene_names_refseq": "3830406C13Rik; Cep15", "protein_names_uniprotkb": "Centrosomal protein 15; Centrosomal protein 15 kDa; Uncharacterized protein C3orf14 homolog", "protein_names_refseq": "centrosomal protein 15 isoform 2; centrosomal protein 15 kDa; uncharacterized protein C3orf14 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:218734)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "May play a role in ciliary assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFA6;Q8R061", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0X2-1", "uniprot_id": [ { "id": "CACL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0X2", "type": "external" } ], "mass": 42106.0, "length": 377, "protein_name": "CDK2-associated and cullin domain-containing protein 1", "gene_name": "Cacul1", "organism": "Mouse", "refseq_name": "CDK2-associated and cullin domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001165567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165567", "type": "external" } ], "gene_names_uniprotkb": "Cacul1; 2700078E11Rik", "gene_names_refseq": "2700078E11Rik; 2810417M16Rik; 9830127L17Rik; Cacul1; D130033C15Rik", "protein_names_uniprotkb": "CDK2-associated and cullin domain-containing protein 1", "protein_names_refseq": "CDK2-associated and cullin domain-containing protein 1 isoform 2; CDK2-associated and cullin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78832)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;26238671;29233982;32782141;35820727;36852467;40885482", "class_list": "", "function": "CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma and inhibit adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Cacul1 regulates the antioxidant response by stabilizing Nrf2. Publication Status: Online-Only, [RefSeq, PubMed]; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE79;Q9CY95", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R0X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XR2-1", "uniprot_id": [ { "id": "AT2C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XR2", "type": "external" } ], "mass": 100299.0, "length": 918, "protein_name": "Calcium-transporting ATPase type 2C member 1", "gene_name": "Atp2c1", "organism": "Mouse", "refseq_name": "calcium-transporting ATPase type 2C member 1 isoform 1", "refseq_ac": [ { "id": "NP_001240760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240760", "type": "external" } ], "gene_names_uniprotkb": "Atp2c1; Pmr1", "gene_names_refseq": "1700121J11Rik; ATP2C1A; Atp2c1; BCPM; D930003G21Rik; HHD; SPCA1; SPCA; pmr1", "protein_names_uniprotkb": "Calcium-transporting ATPase type 2C member 1; 7.2.2.10; ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; Ca(2+)/Mn(2+)-ATPase 2C1; SPCA1; Secretory pathway Ca(2+)-transporting ATPase type 1", "protein_names_refseq": "ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; ATPase, Ca++ transporting, type 2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; calcium-transporting ATPase type 2C member 1 isoform 1; calcium-transporting ATPase type 2C member 1; secretory pathway Ca(2+)-transporting ATPase type 1", "tax_id": 10090, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429)", "pathway": " (mmu:235574); (R-MMU-936837)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14747290;17597066;18599310;19793975;21750661;24530912;25428506;26495903;26740625;28011936;30228103;31219806;34428180;36210013", "class_list": "", "function": "ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (PubMed:19793975). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]; Has a potential role in intracellular signaling and in Golgi secretory processes involved in dendritic growth and in functional maturation of the mouse nervous system., [RefSeq, PubMed]; Impaired cellular divalent calcium ion Ca2+ homeostasis and/or the altered targeting of organellar proteins under conditions of SPCA1 knockdown highlight the importance of SPCA1 function for normal neural differentiation., [RefSeq, PubMed]; Loss of the Golgi Ca(2+) pump causes Golgi stress, expansion of the Golgi, increased apoptosis, and embryonic lethality and demonstrates that SPCA1 haploinsufficiency causes a genetic predisposition to cancer., [RefSeq, PubMed]; SPCA1 promotes neurulation by regulating the cytoskeletal dynamics Publication Status: Online-Only, [RefSeq, PubMed]; The timing, magnitude of TMEM165 expression and its Golgi location supports a role for this Golgi Ca2+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA 1 and 2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QMB9;Q80YZ2", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0008544 epidermis development;GO:0030036 actin cytoskeleton organization;GO:0042998 positive regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80XR2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIR2-1", "uniprot_id": [ { "id": "ASTE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIR2", "type": "external" } ], "mass": 76370.0, "length": 672, "protein_name": "Single-strand DNA endonuclease ASTE1", "gene_name": "Aste1", "organism": "Mouse", "refseq_name": "single-strand DNA endonuclease ASTE1 isoform 1", "refseq_ac": [ { "id": "NP_079927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079927", "type": "external" } ], "gene_names_uniprotkb": "Aste1", "gene_names_refseq": "1100001A21Rik; Aste1", "protein_names_uniprotkb": "Single-strand DNA endonuclease ASTE1; 3.1.-.-; Protein asteroid homolog 1", "protein_names_refseq": "protein asteroid homolog 1; single-strand DNA endonuclease ASTE1 isoform 1; single-strand DNA endonuclease ASTE1", "tax_id": 10090, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:66595)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;30084848;30779550;31219806;34354233;34428180", "class_list": "", "function": "Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA (By similarity). Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ) (PubMed:34354233). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMN1;Q80VC2", "ec_number_list": [], "go_molecular_function": "GO:0000014 single-stranded DNA endodeoxyribonuclease activity;GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BIR2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true } ]