[
    {
        "uniprot_canonical_ac": "O60383-1",
        "uniprot_id": [
            {
                "id": "GDF9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60383",
                "type": "external"
            }
        ],
        "mass": 51444.0,
        "length": 454,
        "protein_name": "Growth/differentiation factor 9",
        "gene_name": "GDF9",
        "organism": "Human",
        "refseq_name": "growth/differentiation factor 9 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001275753",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275753",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GDF9",
        "gene_names_refseq": "GDF9; POF14",
        "protein_names_uniprotkb": "Growth/differentiation factor 9; GDF-9",
        "protein_names_refseq": "growth/differentiation factor 9 isoform 2",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency 14 (Disease Ontology:DOID:0080871)",
        "pathway": " (hsa:2661)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10443672;11237011;12050262;15128595;16278619;16645022;16954162;17156781;17482612;18006624;19366876;19438907;20067794;20660033;21632818;21829661;21970812;29044499;35051231;36372988;36689045;38028840;38643161",
        "class_list": "",
        "function": "Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis., [RefSeq, PubMed]; GDF9[His209GlnfsTer6/S428T] and GDF9[Q321X/S428T] bi-allelic variants caused female subfertility with defective follicle enlargement. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males. Publication Status: Online-Only, [RefSeq, PubMed]; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VAW5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:2000870 regulation of progesterone secretion;GO:0007292 female gamete generation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "O60383-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95800-1",
        "uniprot_id": [
            {
                "id": "GPR75_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95800",
                "type": "external"
            }
        ],
        "mass": 59359.0,
        "length": 540,
        "protein_name": "Probable G protein-coupled receptor 75",
        "gene_name": "GPR75",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 75",
        "refseq_ac": [
            {
                "id": "NP_006785",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006785",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR75",
        "gene_names_refseq": "GPR75; GPRchr2; WI31133",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 75",
        "protein_names_refseq": "probable G-protein coupled receptor 75",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10936)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "10381362;11466257;23979485;29772059;31760076;33974269;34210852;37247305;39302247",
        "class_list": "",
        "function": "G Protein-Coupled Receptor 75 (GPR75) As a Novel Molecule for Targeted Therapy of Cancer and Metabolic Syndrome. Review article Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor., [UniProtKB, PubMed, UniProtKB]; GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]., [RefSeq]; Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity., [RefSeq, PubMed]; Study results show for the first time the involvement of the 20-HETE-GPR75 receptor in the activation of intracellular signaling known to be stimulated in cell malignant transformations leading to the differentiation of PC-3 prostate cancer cells towards a more aggressive phenotype. GPR75 receptor stimulation is necessary for the pro-metastatic actions of 20-HETE in androgen insensitive prostate cancer cells., [RefSeq, PubMed]; This study explored the interaction of CCL5 with GPR75, an orphan receptor of the Gqalpha family of GPCRs, which appears to be expressed more abundantly in neuron-like cells than astrocytes., [RefSeq, PubMed]; Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC02;Q6NWR2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0070098 chemokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "O95800-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0CJ92-1",
        "uniprot_id": [
            {
                "id": "GOG8H_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0CJ92",
                "type": "external"
            }
        ],
        "mass": 71342.0,
        "length": 632,
        "protein_name": "Golgin subfamily A member 8H",
        "gene_name": "GOLGA8H",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 8H",
        "refseq_ac": [
            {
                "id": "NP_001269419",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269419",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GOLGA8H",
        "gene_names_refseq": "GOLGA6L11; GOLGA8H",
        "protein_names_uniprotkb": "Golgin subfamily A member 8H",
        "protein_names_refseq": "Golgin subfamily A member 8-like protein 1; golgi autoantigen, golgin subfamily a, 6-like 11; golgin subfamily A member 8H",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728498)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P0CJ92-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0CL81-1",
        "uniprot_id": [
            {
                "id": "GG12G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0CL81",
                "type": "external"
            }
        ],
        "mass": 12978.0,
        "length": 117,
        "protein_name": "G antigen 12G",
        "gene_name": "GAGE12G",
        "organism": "Human",
        "refseq_name": "G antigen 12G isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001091879",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091879",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GAGE12G",
        "gene_names_refseq": "AL4; CT4.7; GAGE-12G; GAGE12G",
        "protein_names_uniprotkb": "G antigen 12G; GAGE-12G",
        "protein_names_refseq": "G antigen 12F/G/I; G antigen 12G isoform 1; G antigen 12I; cancer/testis antigen 4.7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100008586);  (hsa:2579);  (hsa:26748);  (hsa:645073)",
        "pathway_count": 4,
        "publication_count": 1,
        "publication_id_list": "18179644",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q66I50",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P0CL81-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12544-1",
        "uniprot_id": [
            {
                "id": "GRAA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12544",
                "type": "external"
            }
        ],
        "mass": 28999.0,
        "length": 262,
        "protein_name": "Granzyme A",
        "gene_name": "GZMA",
        "organism": "Human",
        "refseq_name": "granzyme A precursor",
        "refseq_ac": [
            {
                "id": "NP_006135",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006135",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GZMA; CTLA3; HFSP",
        "gene_names_refseq": "CTLA3; GZMA; HFSP",
        "protein_names_uniprotkb": "Granzyme A; 3.4.21.78; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; H factor; HF; Hanukkah factor",
        "protein_names_refseq": "CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; HF; Hanukah factor serine protease); cytotoxic T-lymphocyte proteinase 1; fragmentin-1; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); granzyme A precursor; h factor",
        "tax_id": 9606,
        "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)",
        "pathway": " (hsa:3001)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11555662;12524539;12628186;12819769;12819770;16818237;17180578;19159218;20038786;23739916;28832583;29242379;29557506;29786170;30429286;3047119;32157095;32265295;32299851;3237717;3257574;3262682;3263427;32983136;34022140;34413857;34634775;35256589;36157507;36899106;37074911;37671668;40914422",
        "class_list": "",
        "function": "Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:12819770, PubMed:32299851, PubMed:3257574, PubMed:3262682, PubMed:3263427). It cleaves after Lys or Arg (PubMed:12819770, PubMed:32299851). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851, PubMed:34022140, PubMed:36157507, PubMed:36899106). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]., [RefSeq]; Elevated Extracellular Levels of Granzymes in Patients with Scrub Typhus. Publication Status: Online-Only, [RefSeq, PubMed]; Granzyme A Produced by gamma9delta2 T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 9,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4PHN1;Q6IB36",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001772 immunological synapse;GO:0044194 cytolytic granule",
        "go_biological_process": "GO:0006955 immune response;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031640 killing of cells of another organism;GO:0070269 pyroptotic inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "P12544-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16403-1",
        "uniprot_id": [
            {
                "id": "H12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16403",
                "type": "external"
            }
        ],
        "mass": 21365.0,
        "length": 213,
        "protein_name": "Histone H1.2",
        "gene_name": "H1-2",
        "organism": "Human",
        "refseq_name": "histone H1.2",
        "refseq_ac": [
            {
                "id": "NP_005310",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005310",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-2; H1F2; HIST1H1C",
        "gene_names_refseq": "H1-2; H1.2; H1C; H1F2; H1s-1; HIST1H1C",
        "protein_names_uniprotkb": "Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1",
        "protein_names_refseq": "H1 histone family, member 2; histone 1, H1c; histone H1.2; histone H1c; histone H1d; histone H1s-1; histone cluster 1 H1 family member c; histone cluster 1, H1c",
        "tax_id": 9606,
        "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:3006);  (R-HSA-140342);  (R-HSA-2559584)",
        "pathway_count": 3,
        "publication_count": 143,
        "publication_id_list": "10318789;10713148;10997781;12408966;12748178;15149602;15569692;15595731;15621527;15655109;15910001;15911621;15944288;16377619;16901784;17043054;17081983;17145369;17158953;17242198;17242207;17287340;17924679;17938174;18212344;18239742;18283539;18566446;18669648;19007248;19029251;19054851;19117535;19413330;19651622;19691289;20058876;20068231;20305658;20334638;20439994;21406692;21807893;21925322;22223895;22249259;23481700;23739916;23964094;24601643;24681537;24715725;25576301;25802875;2613692;26154972;26375851;26581166;26758079;26992070;27452731;2759094;27600516;27723750;27726376;27846572;27920218;28063628;28228285;28446606;28514659;28539972;28832583;28834231;28855257;28904123;29242379;29301938;29331515;29393594;29508533;29557506;29632046;29632711;29786170;29789417;30154464;30192525;30315122;30429286;30444036;30524438;31020640;31032946;31154438;31611695;31717259;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32350084;32387766;32897882;32938616;32983136;33043033;33091337;33141586;33214551;33392160;33592498;33936100;33981976;34019948;34171305;34357683;34433824;34545082;34725712;34961760;35051231;35154160;35251023;35580925;36215666;36284347;36435862;37217939;37429872;37922872;37994785;38399950;38530350;38665916;40240600;40516528;40914422;8003976;9108473",
        "class_list": "",
        "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:26581166, PubMed:38530350). Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibers (PubMed:38530350). Compared to other histone H1 variants, H1-2 plays an essential role in nucleosome condensation: its absence leads to global chromatin decompaction, which is not observed when depleting other histone H1 variants (PubMed:38530350). Histone H1-2 also acts as a histone reader: specifically recognizes and binds histone H3 trimethylated at 'lys-27' (H3K27me3) (PubMed:26581166). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication (PubMed:37429872, PubMed:40516528). Together with histone H1-3, histone H1-2 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-2 has a high affinity for exons and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (PubMed:37922872). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (PubMed:38530350)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-beta Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]., [RefSeq]; Interactome of intact chromatosome variants with site-specifically ubiquitylated and acetylated linker histone H1.2., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4I2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0061628 histone H3K27me3 reader activity;GO:0031492 nucleosomal DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000791 euchromatin;GO:0000792 heterochromatin",
        "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0140718 facultative heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "P16403-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22492-1",
        "uniprot_id": [
            {
                "id": "H1T_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22492",
                "type": "external"
            }
        ],
        "mass": 22019.0,
        "length": 207,
        "protein_name": "Histone H1t",
        "gene_name": "H1-6",
        "organism": "Human",
        "refseq_name": "histone H1t",
        "refseq_ac": [
            {
                "id": "NP_005314",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005314",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-6; H1FT; H1T; HIST1H1T",
        "gene_names_refseq": "H1-6; H1.6; H1FT; H1t; HIST1H1T; dJ221C16.2",
        "protein_names_uniprotkb": "Histone H1t; Testicular H1 histone",
        "protein_names_refseq": "H1 histone family, member T (testis-specific); histone 1, H1t; histone H1t; histone cluster 1 H1 family member t; histone cluster 1, H1t; testicular H1 histone",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3010)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "12408966;17081983;1889752;20068231;24714562;26757249;26992070;27452731;28218747;28228285;28832583;28855257;29242379;29314611;29393594;29508533;29786170;29789417;30524438;31848261;32897882;35051231;37217939;8175896",
        "class_list": "",
        "function": "Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]., [RefSeq]; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable)., [UniProtKB, PubMed]; These results suggested that the testis-specific linker histone, H1T, possesses a specific function to produce the chromatin architecture required for proper chromosome regulation, such as homologous recombination., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ISI1;Q8IUE8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "P22492-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22749-1",
        "uniprot_id": [
            {
                "id": "GNLY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22749",
                "type": "external"
            }
        ],
        "mass": 16374.0,
        "length": 145,
        "protein_name": "Granulysin",
        "gene_name": "GNLY",
        "organism": "Human",
        "refseq_name": "granulysin isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001289687",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289687",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GNLY; LAG2; NKG5; TLA519",
        "gene_names_refseq": "D2S69E; GNLY; LAG-2; LAG2; NKG5; TLA519",
        "protein_names_uniprotkb": "Granulysin; Lymphokine LAG-2; Protein NKG5; T-cell activation protein 519",
        "protein_names_refseq": "T-cell activation protein 519; T-lymphocyte activation gene 519; granulysin isoform 1 precursor; lymphocyte-activation gene 2; lymphokine LAG-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10578);  (R-HSA-6803157)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "10449094;10644038;11120840;11237011;11313366;11389039;11971875;12488100;12493837;13816;14506276;14739326;1522221;15229136;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16799473;16931762;16940129;17363965;17502600;17567961;17964057;18021746;18160480;18185531;18673279;19095652;19179970;19254208;19818633;20103720;20180804;20382864;20395631;20510021;20845358;21787330;2212946;22262861;22327069;22455996;22701042;23302724;23426625;23555621;24219363;24256734;2434598;25075772;25461571;25596890;26148048;27089320;27862975;29242379;29557506;3286634;32983136;34093532;34445098;34691030;35066979;35494241;38471344;8423048;9523110;9665269;9756476",
        "class_list": "",
        "function": "A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin. Publication Status: Online-Only, [RefSeq, PubMed]; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis., [UniProtKB]; GNLY gene polymorphism: A potential role in understanding psoriasis pathogenesis., [RefSeq, PubMed]; Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis. Publication Status: Online-Only, [RefSeq, PubMed]; Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome., [RefSeq, PubMed]; Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies. Publication Status: Online-Only, [RefSeq, PubMed]; Peptides encoded by this gene display antimicrobial activity against S. typhimurium, L. monocytogenes, E. coli, S. aureus, C. neoformans, C. albicans, L. major, and M. tuberculosis. Review article, [RefSeq, PubMed]; The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P09325;Q6GU08",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0097013 phagocytic vesicle lumen",
        "go_biological_process": "GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006968 cellular defense response;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0050832 defense response to fungus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.7,
        "record_id": "P22749-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P24046-1",
        "uniprot_id": [
            {
                "id": "GBRR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P24046",
                "type": "external"
            }
        ],
        "mass": 55883.0,
        "length": 479,
        "protein_name": "Gamma-aminobutyric acid receptor subunit rho-1",
        "gene_name": "GABRR1",
        "organism": "Human",
        "refseq_name": "gamma-aminobutyric acid receptor subunit rho-1 isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_001243632",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243632",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GABRR1",
        "gene_names_refseq": "GABRR1",
        "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1",
        "protein_names_refseq": "GABA(A) receptor subunit rho-1; GABA(A) receptor, rho 1; GABA(C) receptor; GABAAR subunit rho-1; bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1); gamma-aminobutyric acid (GABA) A receptor, rho-1; gamma-aminobutyric acid receptor subunit rho-1 isoform b precursor; gamma-aminobutyric acid receptor subunit rho-1; gamma-aminobutyric acid type A receptor rho1 subunit",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:2569);  (R-HSA-977443)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10449790;10542332;10779366;11237011;12175859;1315307;1321750;15024690;1664410;17364682;17398006;18382465;1849271;19828786;2465923;27244450;2847710;28623169;28660714;28699326;29557506;33912179;37659407;39242530;8264558;8382267;8391122;8632757;8719414;8719416",
        "class_list": "",
        "function": "Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor. Publication Status: Online-Only, [RefSeq, PubMed]; GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]; GABAergic genes interacting with parenting in adolescent depressive symptoms: GABRR1 X perceived parental support interaction., [RefSeq, PubMed]; Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (PubMed:37659407). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:37659407). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (PubMed:1849271). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Study determined that levels of GABAA receptors rho1 and rho2 are not altered in the cerebellum of WT and rho1 knockin mice. In addition, findings show that mutation of the inhibitory ethanol site in rho1 does not alter normal channel function, but is important for the development of acute tolerance to ethanol-induced motor impairment., [RefSeq, PubMed]; The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1 rs1186902) shows a statistically significant association with the age of onset of migraine., [RefSeq, PubMed]; Thr244 of rho1 GABAC Receptors is an important residue for channel activation as it forms a H-bond with agonists, initiating the conformational changes required for priming of the receptor and stabilizes the open conformation (review). Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L401;B4DJK8;B4DQT5;B7ZBQ7;Q9BX06",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0097708 intracellular vesicle;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane",
        "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P24046-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P34947-1",
        "uniprot_id": [
            {
                "id": "GRK5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P34947",
                "type": "external"
            }
        ],
        "mass": 67787.0,
        "length": 590,
        "protein_name": "G protein-coupled receptor kinase 5",
        "gene_name": "GRK5",
        "organism": "Human",
        "refseq_name": "G protein-coupled receptor kinase 5",
        "refseq_ac": [
            {
                "id": "NP_005299",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005299",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GRK5; GPRK5",
        "gene_names_refseq": "FP2025; GPRK5; GRK5",
        "protein_names_uniprotkb": "G protein-coupled receptor kinase 5; 2.7.11.16; G protein-coupled receptor kinase GRK5",
        "protein_names_refseq": "G protein-coupled receptor kinase 5; g protein-coupled receptor kinase GRK5",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:2869);  (R-HSA-416476);  (R-HSA-418555)",
        "pathway_count": 3,
        "publication_count": 107,
        "publication_id_list": "10.1101/2023.09.13.557529;10191087;10567430;10727532;10861009;11007482;11015615;11742120;11753430;12036966;12058044;12106601;12120503;12180353;12860470;13549488;14671004;14976207;1517224;15542828;15765929;15769620;15951850;16182515;16268778;16313925;16339447;16687412;16754659;16923326;17168849;17344846;18044684;18425130;18434541;18515384;18577758;18669648;18936096;1905813;19092051;19105585;19651622;19661922;19801552;19876791;19929708;20038610;20068231;20124405;20381629;21036126;21097543;2163110;21728385;2417744;24687066;2491850;2553411;2553705;26154972;26375851;26417854;27920218;2841328;2871555;28904123;29393594;29443750;29493099;29602314;30833991;3086311;3127824;31279028;31399091;31844290;31983287;32226383;32350084;32497535;32540603;32618402;32715661;33049737;33912179;35051231;35412954;36584571;38206179;38822544;39033880;6085243;7685906;7937899;8144599;8340388;8381058;8514797;8664309;8672451;9218466;9263355;9305846;9417641;9651336;9770463",
        "class_list": "",
        "function": "Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan., [RefSeq, PubMed]; GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway., [RefSeq, PubMed]; Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-kappaB-mediated inflammation., [RefSeq, PubMed]; LncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5., [RefSeq, PubMed]; Porphyromonas gingivalis virulence factors induce toxic effects in SH-SY5Y neuroblastoma cells: GRK5 modulation as a protective strategy., [RefSeq, PubMed]; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRD0;Q5T059",
        "ec_number_list": [
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15",
                "type": "external"
            },
            {
                "id": "2.7.11.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding;GO:0005080 protein kinase C binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "P34947-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13491-1",
        "uniprot_id": [
            {
                "id": "GPM6B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13491",
                "type": "external"
            }
        ],
        "mass": 28989.0,
        "length": 265,
        "protein_name": "Neuronal membrane glycoprotein M6-b",
        "gene_name": "GPM6B",
        "organism": "Human",
        "refseq_name": "neuronal membrane glycoprotein M6-b isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001001994",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001994",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPM6B; M6B",
        "gene_names_refseq": "GPM6B; M6B",
        "protein_names_uniprotkb": "Neuronal membrane glycoprotein M6-b; M6b",
        "protein_names_refseq": "neuronal membrane glycoprotein M6-b isoform 4; neuronal membrane glycoprotein M6-b; protolipid M6B",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:2824)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15214007;18581270;19531498;21638316;22869377;25113253;25576301;25645385;27600516;29557506;30372567;30568303;30779550;31154438;31844290;31848261;32157095;32488085;32502341;33294057;33392160;35051231;37938771;8661015;9674909",
        "class_list": "",
        "function": "Findings demonstrate that GPM6B plays a crucial role in SMC differentiation and regulates SMC differentiation through the activation of TGF-beta-Smad2/3 signaling via direct interactions with TbetaRI., [RefSeq, PubMed]; GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity. Publication Status: Online-Only, [RefSeq, PubMed]; Increase in the expression levels of mRNA and protein for the Gpm6B is associated with various types of gynaecological malignancy., [RefSeq, PubMed]; It is unlikely that mutations in M6B have a role in Pelizaeus-Merzbacher-like syndrome, as examined in eight patients, [RefSeq, PubMed]; May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake., [UniProtKB, PubMed]; This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O76077;Q86X43;Q8N956",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019911 structural constituent of myelin sheath",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0016020 membrane",
        "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0085029 extracellular matrix assembly;GO:0007399 nervous system development;GO:0015031 protein transport;GO:0022010 central nervous system myelination",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q13491-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14549-1",
        "uniprot_id": [
            {
                "id": "GBX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14549",
                "type": "external"
            }
        ],
        "mass": 37629.0,
        "length": 363,
        "protein_name": "Homeobox protein GBX-1",
        "gene_name": "GBX1",
        "organism": "Human",
        "refseq_name": "homeobox protein GBX-1",
        "refseq_ac": [
            {
                "id": "NP_001092304",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092304",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GBX1",
        "gene_names_refseq": "GBX1; Huh-17",
        "protein_names_uniprotkb": "Homeobox protein GBX-1; Gastrulation and brain-specific homeobox protein 1",
        "protein_names_refseq": "gastrulation and brain-specific homeobox protein 1; homeobox protein GBX-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2636)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "16597639;27396829;28832583;29557506;35051231;8097731",
        "class_list": "",
        "function": "Dynamic local polymorphisms in the Gbx1 homeodomain induced by DNA binding have been reported., [RefSeq, PubMed]; Study reveals the preferential expression of GBX1 by germinal vesicle (GV) oocytes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051960 regulation of nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q14549-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16099-1",
        "uniprot_id": [
            {
                "id": "GRIK4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16099",
                "type": "external"
            }
        ],
        "mass": 107246.0,
        "length": 956,
        "protein_name": "Glutamate receptor ionotropic, kainate 4",
        "gene_name": "GRIK4",
        "organism": "Human",
        "refseq_name": "glutamate receptor ionotropic, kainate 4 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001269399",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269399",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GRIK4; GRIK",
        "gene_names_refseq": "EAA1; GRIK4; GRIK; GluK4-2; GluK4; KA1",
        "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 4; EAA1; Excitatory amino acid receptor 1; GluK4; Glutamate receptor KA-1; KA1",
        "protein_names_refseq": "GluK4(alt_5'UTR); excitatory amino acid receptor 1; glutamate receptor KA1; glutamate receptor ionotropic, kainate 4 isoform 1 precursor; glutamate receptor, ionotropic, kainate 4; putative NMDtranscript(altAcc_e11)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2900);  (R-HSA-451308)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "18510355;19342380;23481700;24715725;25576301;29243543;31066578;32245654;32265295;32938616;33936100;36010968;8263508;8782898;9625352",
        "class_list": "",
        "function": "GluK4 deletion carriers who had a mental health problem (predominately depression) showed better performance in visuo-spatial ability and mental processing speed compared to individuals with mental health problems homozygous for the insertion., [RefSeq, PubMed]; Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression., [RefSeq, PubMed]; In addition, while GRIK4 was not associated with sertraline tolerability and response, both HTR2A and SLC6A4 could influence tolerability and accelerate treatment response in pediatric patients., [RefSeq, PubMed]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own (PubMed:8263508). Shows channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits (By similarity)., [UniProtKB, PubMed, UniProtKB]; This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 61,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9L1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane",
        "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0007215 glutamate receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q16099-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q49SQ1-1",
        "uniprot_id": [
            {
                "id": "GPR33_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q49SQ1",
                "type": "external"
            }
        ],
        "mass": 38232.0,
        "length": 333,
        "protein_name": "Probable G protein-coupled receptor 33",
        "gene_name": "GPR33",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 33",
        "refseq_ac": [
            {
                "id": "NP_001184113",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184113",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR33",
        "gene_names_refseq": "GPR33",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 33",
        "protein_names_refseq": "G protein-coupled receptor 33 pseudogene; probable G-protein coupled receptor 33",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2856)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "15987686;20399748;23481700;29242379;35051231",
        "class_list": "",
        "function": "Cloning and analysis of more than 120 mammalian GPR33 orthologs from 16 of 18 eutherian orders revealed an inactivation of this chemoattractant GPCR not only in humans, but also in several great ape and rodent species., [RefSeq, PubMed]; Orphan receptor; could be a chemoattractant receptor., [UniProtKB]; These data indicate an important role of GPR33 function in innate immunity which became dispensable during human evolution most likely due to past or balancing selection., [RefSeq, PubMed]; This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q49SQ1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HCL2-1",
        "uniprot_id": [
            {
                "id": "GPAT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HCL2",
                "type": "external"
            }
        ],
        "mass": 93795.0,
        "length": 828,
        "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial",
        "gene_name": "GPAM",
        "organism": "Human",
        "refseq_name": "glycerol-3-phosphate acyltransferase 1, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_001231878",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231878",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPAM; GPAT1; KIAA1560",
        "gene_names_refseq": "GPAM; GPAT1; GPAT",
        "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 1, mitochondrial; 2.3.1.15; GPAT-1",
        "protein_names_refseq": "GPAT-1; glycerol-3-phosphate acyltransferase 1, mitochondrial precursor; glycerol-3-phosphate acyltransferase 1, mitochondrial",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nephrotic syndrome (Disease Ontology:DOID:1184); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:57678);  (R-HSA-1483166);  (R-HSA-2426168);  (R-HSA-75109);  (R-HSA-8931987);  (R-HSA-9018519);  (R-HSA-9841922)",
        "pathway_count": 7,
        "publication_count": 299,
        "publication_id_list": "10400691;10425206;10455175;10500157;10506173;10553003;10558993;10681567;10759542;10828826;10835357;10873660;10882139;11010967;11027271;11031251;11034064;11103799;11112443;11136970;11165043;11237011;11345900;11410592;11414710;11452016;11481335;11581164;11672446;11682626;11788596;11830583;12063250;12083769;12161451;12177166;12359733;12498683;12522102;12612073;12618427;12764144;12824082;12829629;12959972;12963729;1310260;1377680;14521909;14573790;14631847;14675539;14970677;15001666;15276198;15282324;15343269;15345050;15367102;15514030;15845384;15986123;16009131;16046058;16087863;16113099;1630819;16380219;16460752;16495223;16620771;16704971;16864775;16980581;17013392;17028579;17081983;17158099;17170135;17277772;17449569;17463000;17495528;17510434;17637753;17666587;17690249;17707131;17761950;17924679;17925399;18187655;18219272;18238778;18256232;18318008;18322535;18358809;18452278;18476782;18533032;18559965;18654640;18682402;18694939;18718904;18726356;18762174;18805503;19001364;19020303;19043829;19075029;19098913;19172745;19274700;19295514;19321454;19336658;19383337;19651622;19666841;1968462;19718048;20138239;20166139;20219941;20220130;20450493;20498280;20547749;20570965;20643956;20682797;20705608;20719759;20937905;21106759;21151129;21173190;21445275;21573489;2181374;21835891;21878914;21934649;21940756;22056668;22265404;22492511;22545144;22634312;22704330;22777291;22922100;23145106;23172872;23176821;23176823;23192763;23303788;23403292;23435229;23481700;23723241;23807634;23906331;24167369;24275569;24371278;24397554;24735615;24854081;24885040;24966474;24973012;24998469;25296600;25365482;25433557;25542856;25576301;25633194;25663755;25674852;25728767;25838202;25880248;26056233;26153859;26154972;26204489;26462610;26479350;26711011;26916619;26992070;27062924;27600516;27846572;27886276;27920218;28514659;28539435;28649982;28832583;28904123;2919170;29242379;2925608;29557506;29769354;29786170;29789417;30379171;30429286;3045126;30524438;31844290;32157095;32357974;32387766;32488085;3281094;32897882;32938616;32983136;33141586;33298915;33329381;33347879;33537174;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34211107;34216018;34405274;34509645;34561969;3458202;34932366;3498214;35051231;35580925;35662157;36241641;36522428;3677090;37938771;7060561;7559524;7567999;7592729;7732023;7821823;7909540;7935485;7937828;8020941;8163052;8186247;8195246;8197458;8300559;8419924;8521497;8521498;8530346;8619637;8626466;8626488;8647822;8663599;8687421;8798690;8876171;8976377;9065481;9099716;9171241;9188469;9201922;9212163;9338790;9388265;9461603;9582313;9604010;9611253;9634533;9671459;9731700;9744270;9748295",
        "class_list": "",
        "function": "Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease., [RefSeq, PubMed]; Genetic Variation in the Mitochondrial Glycerol-3-Phosphate Acyltransferase Is Associated With Liver Injury., [RefSeq, PubMed]; Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:18238778, PubMed:19075029, PubMed:36522428). Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid (PubMed:18238778). Has a narrow hydrophobic binding cleft that selects for a linear acyl chain (PubMed:36522428). Catalytic activity is higher for substrates with a 16-carbon acyl chain (PubMed:36522428)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Structural basis of the acyl-transfer mechanism of human GPAT1., [RefSeq, PubMed]; This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]., [RefSeq]; [Identification of GPAT1-dependent mitochondrial metabolism as a novel therapeutic target for AML]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VW51;Q86TA3",
        "ec_number_list": [
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "1.14.11.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006655 phosphatidylglycerol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 30.2,
        "record_id": "Q9HCL2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6DRA6-1",
        "uniprot_id": [
            {
                "id": "H2B2D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6DRA6",
                "type": "external"
            }
        ],
        "mass": 18018.0,
        "length": 164,
        "protein_name": "Putative histone H2B type 2-D",
        "gene_name": "H2BC19P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "H2BC19P; HIST2H2BD",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative histone H2B type 2-D; H2B-clustered histone 19 pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 18,
        "publication_id_list": "12408966;12757711;15527963;16283522;21925322;22389435;24681537;27105113;27105115;30154464;31542297;32938616;33968037;33981976;34211107;34509645;34545082;34961760",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6DRA6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UXV0-1",
        "uniprot_id": [
            {
                "id": "GFRAL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UXV0",
                "type": "external"
            }
        ],
        "mass": 44518.0,
        "length": 394,
        "protein_name": "GDNF family receptor alpha-like",
        "gene_name": "GFRAL",
        "organism": "Human",
        "refseq_name": "GDNF family receptor alpha-like precursor",
        "refseq_ac": [
            {
                "id": "NP_997293",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997293",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GFRAL; C6orf144; PRO34128",
        "gene_names_refseq": "C6orf144; GFRAL; GRAL; UNQ9356; bA360D14.1",
        "protein_names_uniprotkb": "GDNF family receptor alpha-like",
        "protein_names_refseq": "GDNF family receptor alpha-like precursor; IVFI9356",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389400)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "12975309;16959974;28846097;28846098;28846099;28953886;29144449;29632711;31535977;32661391;33201838;33852427;35177851;36630958;38254638",
        "class_list": "",
        "function": "Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice., [RefSeq, PubMed]; Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:32661391). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (PubMed:31535977, PubMed:32661391). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:32661391)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-wide association and transcriptome analysis suggests total serum ghrelin to be linked with GFRAL. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulated GDF-15 expression facilitates pancreatic ductal adenocarcinoma progression through orphan receptor GFRAL., [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VTF6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity;GO:0030971 receptor tyrosine kinase binding;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0007399 nervous system development;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0032099 negative regulation of appetite;GO:1901558 response to metformin",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q6UXV0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZN66-1",
        "uniprot_id": [
            {
                "id": "GBP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZN66",
                "type": "external"
            }
        ],
        "mass": 72427.0,
        "length": 633,
        "protein_name": "Guanylate-binding protein 6",
        "gene_name": "GBP6",
        "organism": "Human",
        "refseq_name": "guanylate-binding protein 6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_940862",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940862",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GBP6",
        "gene_names_refseq": "GBP6",
        "protein_names_uniprotkb": "Guanylate-binding protein 6; 3.6.5.-; GBP-6; GTP-binding protein 6; Guanine nucleotide-binding protein 6",
        "protein_names_refseq": "GBP-6; GTP-binding protein 6; guanine nucleotide-binding protein 6; guanylate-binding protein 6 isoform 1; guanylate-binding protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:163351);  (R-HSA-877300);  (R-HSA-9956593)",
        "pathway_count": 3,
        "publication_count": 69,
        "publication_id_list": "10067896;10986460;11972023;12040185;12438563;12446674;12915721;1396683;14586410;14722222;1508672;15143187;15322115;15388922;15530433;16237089;16467876;17125875;18362138;18591661;20049711;20130243;20237496;20304997;20363976;20423481;22424782;23061660;23516580;24417533;25576301;26758079;28593173;28904123;29024643;29144452;31154438;31216343;31217245;31844290;32357974;32488085;32938616;32983136;33239784;33592498;33633747;33968037;34671164;35051231;35580925;36624349;7510216;7514165;7530745;7615558;7617032;7657660;7673114;7690989;7796299;8156998;8176225;8483949;8530158;8550631;8631301;9111318;9143706",
        "class_list": "",
        "function": "Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]., [RefSeq]; Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity)., [UniProtKB, UniProtKB]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRM3;Q6ZN86;Q7Z3F0",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.84",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84",
                "type": "external"
            },
            {
                "id": "1.8.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-",
                "type": "external"
            },
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "6.3.2.n3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0070062 extracellular exosome;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0006955 immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0071346 cellular response to type II interferon;GO:0042832 defense response to protozoan",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q6ZN66-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z2K8-1",
        "uniprot_id": [
            {
                "id": "GRIN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z2K8",
                "type": "external"
            }
        ],
        "mass": 102399.0,
        "length": 1008,
        "protein_name": "G protein-regulated inducer of neurite outgrowth 1",
        "gene_name": "GPRIN1",
        "organism": "Human",
        "refseq_name": "G protein-regulated inducer of neurite outgrowth 1",
        "refseq_ac": [
            {
                "id": "NP_443131",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443131",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPRIN1; KIAA1893",
        "gene_names_refseq": "GPRIN1; GRIN1",
        "protein_names_uniprotkb": "G protein-regulated inducer of neurite outgrowth 1; GRIN1",
        "protein_names_refseq": "G protein-regulated inducer of neurite outgrowth 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114787);  (R-HSA-9022699)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10480904;15302935;18578522;20166139;23186163;24150225;25424712;26214522;26992070;28218747;28228285;28657654;29242379;29437277;30315122;30410026;31217245;31844290;32387766;32502341;33912179;33968037;34453499;35051231;39302247",
        "class_list": "",
        "function": "A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma., [RefSeq, PubMed]; May be involved in neurite outgrowth., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JM70;Q8ND74;Q96PZ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051219 phosphoprotein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030426 growth cone",
        "go_biological_process": "GO:0031175 neuron projection development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q7Z2K8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86SP6-1",
        "uniprot_id": [
            {
                "id": "GP149_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86SP6",
                "type": "external"
            }
        ],
        "mass": 80984.0,
        "length": 731,
        "protein_name": "Probable G protein-coupled receptor 149",
        "gene_name": "GPR149",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 149",
        "refseq_ac": [
            {
                "id": "NP_001033794",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033794",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR149; PGR10",
        "gene_names_refseq": "GPR149; IEDA; PGR10; R35",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 149; G protein-coupled receptor PGR10",
        "protein_names_refseq": "G protein-coupled receptor PGR10; probable G-protein coupled receptor 149",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:344758)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "12679517;25892735;31115548;32983136;33912179;35051231;35494241",
        "class_list": "",
        "function": "Data revealed that hypermethylation of ZNF492 and GPR149 was significantly associated with shorter timetoprogression of patients with clear cell renal cell carcinoma (ccRCC). Hypermethylation of ZNF492 and GPR149 may be independent predictors of tumor progression. Similarly, the methylation status of these two genes was significantly associated with poor outcomes in the independent external validation cohort., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86SP6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N0V5-1",
        "uniprot_id": [
            {
                "id": "GCNT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N0V5",
                "type": "external"
            }
        ],
        "mass": 45873.0,
        "length": 402,
        "protein_name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase",
        "gene_name": "GCNT2",
        "organism": "Human",
        "refseq_name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B",
        "refseq_ac": [
            {
                "id": "NP_001482",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001482",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GCNT2; GCNT5; IGNT; II; NACGT1",
        "gene_names_refseq": "CCAT; CTRCT13; GCNT2C; GCNT2; GCNT5; IGNT; II; NACGT1; NAGCT1; ULG3; bA360O19.2; bA421M1.1",
        "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; 2.4.1.150; I-branching enzyme; IGNT; N-acetylglucosaminyltransferase",
        "protein_names_refseq": "I beta-1,6-N-acetylglucosaminyltransferase; Ii blood group; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; beta-1,6-N-acetylglucosaminyltransferase 2; glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)",
        "tax_id": 9606,
        "disease": "cataract 13 with adult i phenotype (Disease Ontology:DOID:0110242); cataract (Disease Ontology:DOID:83); obsolete blood group, 1 system (MONDO:MONDO:0044220)",
        "pathway": " (hsa:2651)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "10.1101/2023.09.13.557529;11230166;11237011;11739194;12424189;12468428;14672974;23090970;24190977;24715725;25645385;28467828;28839118;28904123;29242379;29914532;30833945;31844290;32350084;32488085;33660254;33968037;34357683;34932366;35051231;35154160;35318648;7579796;8449405",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans (PubMed:12424189, PubMed:8449405). Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells., [UniProtKB, PubMed, PubMed, PubMed]; Determines the expression of the blood group I antigen in erythrocytes., [UniProtKB, PubMed]; Melanoma-associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target. Review article, [RefSeq, PubMed]; This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 557,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q06430;Q5T4J1;Q5W0E9;Q6T5E5;Q8NFS9",
        "ec_number_list": [
            {
                "id": "2.4.1.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102",
                "type": "external"
            },
            {
                "id": "2.4.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150",
                "type": "external"
            },
            {
                "id": "2.4.1.148",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0008194 UDP-glycosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007275 multicellular organism development;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 2877,
        "hit_score": 3.4,
        "record_id": "Q8N0V5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000000.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NDV2-1",
        "uniprot_id": [
            {
                "id": "GPR26_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NDV2",
                "type": "external"
            }
        ],
        "mass": 37604.0,
        "length": 337,
        "protein_name": "G protein-coupled receptor 26",
        "gene_name": "GPR26",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 26",
        "refseq_ac": [
            {
                "id": "NP_703143",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703143",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR26",
        "gene_names_refseq": "GPR26",
        "protein_names_uniprotkb": "G protein-coupled receptor 26",
        "protein_names_refseq": "G-protein coupled receptor 26",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2849)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "17363172;18037267;19787267;26303144;29493099;29557506;32024457",
        "class_list": "",
        "function": "Epigenetic silencing is a common mechanism in malignant gliomas that simultaneously inactivates MGMT and GPR26, [RefSeq, PubMed]; GPR26 may have a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases, [RefSeq, PubMed]; MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties., [RefSeq, PubMed]; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP., [UniProtKB, PubMed]; Study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development., [RefSeq, PubMed]; This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M2E2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NDV2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NFN8-1",
        "uniprot_id": [
            {
                "id": "GP156_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NFN8",
                "type": "external"
            }
        ],
        "mass": 89097.0,
        "length": 814,
        "protein_name": "Probable G protein-coupled receptor 156",
        "gene_name": "GPR156",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 156 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001161743",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161743",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR156; GABABL; PGR28",
        "gene_names_refseq": "DFNB121; GABABL; GPR156; PGR28",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 156; G protein-coupled receptor PGR28; GABAB-related G protein-coupled receptor",
        "protein_names_refseq": "G protein-coupled receptor PGR28; GABAB-related G-protein coupled receptor; probable G-protein coupled receptor 156 isoform 2; probable G-protein coupled receptor 156",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); autosomal recessive nonsyndromic deafness 121 (Disease Ontology:DOID:0070675)",
        "pathway": " (hsa:165829)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;12591167;12679517;20677014;23481700;31844290;35051231;36928819;37814107;39760840",
        "class_list": "",
        "function": "G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]., [RefSeq]; Novel GPR156 variants confirm its role in moderate sensorineural hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Orphan G protein-coupled receptor involved in the regulation of hair cell orientation in mechanosensory organs of the inner ear. It is required to trigger a 180 degree reversal in hair cell orientation, creating a virtual line of polarity reversal (LPR) across which stereociliary bundles are arranged in opposite orientations., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZL66;E9PFZ4;Q14CM1;Q86SN6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004965 G protein-coupled GABA receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0038039 G protein-coupled receptor heterodimeric complex",
        "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0160194 stereocilium bundle organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8NFN8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TDV0-1",
        "uniprot_id": [
            {
                "id": "GP151_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TDV0",
                "type": "external"
            }
        ],
        "mass": 46637.0,
        "length": 419,
        "protein_name": "G protein-coupled receptor 151",
        "gene_name": "GPR151",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 151",
        "refseq_ac": [
            {
                "id": "NP_919227",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919227",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR151; GALR4; GALRL; PGR7",
        "gene_names_refseq": "GALR4; GALRL; GPCR-2037; GPCR; GPR151; PGR7",
        "protein_names_uniprotkb": "G protein-coupled receptor 151; G protein-coupled receptor PGR7; GPCR-2037; GalRL; Galanin receptor 4; Galanin-receptor-like protein",
        "protein_names_refseq": "G-protein coupled receptor 151; G-protein coupled receptor PGR7; galanin receptor 4; galanin-receptor-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:134391)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "12044878;12679517;15111018;20934997;29632711;31119277;31154438;32098843;32387766;32938616;33968037;35011589;35051231;35251023;35381001;35580925",
        "class_list": "",
        "function": "Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Northern blot analysis reveals expression of galanin-receptor like (GalRL) in the central nervous system with minor levels in peripheral organs and tissues, such as testis, liver, kidney and stomach., [RefSeq, PubMed]; Proton-sensing G protein-coupled receptor., [UniProtKB, PubMed]; These data identify GPR151 as a critical modulator of habenular function that controls nicotine addiction vulnerability, [RefSeq, PubMed]; This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86SN8;Q8NGV2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane;GO:0098981 cholinergic synapse",
        "go_biological_process": "GO:0002931 response to ischemia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0010447 response to acidic pH;GO:0050778 positive regulation of immune response;GO:2000300 regulation of synaptic vesicle exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q8TDV0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TDV2-1",
        "uniprot_id": [
            {
                "id": "GP148_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TDV2",
                "type": "external"
            }
        ],
        "mass": 38288.0,
        "length": 347,
        "protein_name": "Probable G protein-coupled receptor 148",
        "gene_name": "GPR148",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 148",
        "refseq_ac": [
            {
                "id": "NP_997247",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997247",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR148; BTR; PGR6",
        "gene_names_refseq": "BTR; GPR148; PGR6",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 148; Brain and testis restricted GPCR; G protein-coupled receptor PGR6",
        "protein_names_refseq": "G protein-coupled receptor PGR6; brain and testis restricted GPCR; probable G-protein coupled receptor 148",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:344561)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "12044878;12679517;15688318;22543972;35051231",
        "class_list": "",
        "function": "Orphan receptor., [UniProtKB]; Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific GPR148, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M369;Q86SP7;Q86U87",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8TDV2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TDV5-1",
        "uniprot_id": [
            {
                "id": "GP119_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TDV5",
                "type": "external"
            }
        ],
        "mass": 36889.0,
        "length": 335,
        "protein_name": "Glucose-dependent insulinotropic receptor",
        "gene_name": "GPR119",
        "organism": "Human",
        "refseq_name": "glucose-dependent insulinotropic receptor",
        "refseq_ac": [
            {
                "id": "NP_848566",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848566",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR119",
        "gene_names_refseq": "GPCR2; GPR119",
        "protein_names_uniprotkb": "Glucose-dependent insulinotropic receptor; G protein-coupled receptor 119",
        "protein_names_refseq": "G-protein coupled receptor 2; glucose-dependent insulinotropic receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139760);  (R-HSA-381771);  (R-HSA-400511)",
        "pathway_count": 3,
        "publication_count": 38,
        "publication_id_list": "10366038;11564718;11978683;12044878;12540594;12651102;12810581;14623098;14719035;14719797;1499644;15126524;15584901;15607732;15619630;16219666;16517404;16728727;17065399;17681422;18202141;18519800;18593849;19001044;2890159;29883799;30078552;30828317;32142797;33242325;35049225;35051231;3841689;3900195;7883856;8100523;8428636;8798518",
        "class_list": "",
        "function": "GPR116 overexpression correlates with poor prognosis in gastric cancer., [RefSeq, PubMed]; GPR119 Is a Potent Regulator of Human Sebocyte Biology., [RefSeq, PubMed]; GPR119 is the oleoyl-lysophosphatidylinositol receptor that is required for GLP-1 secretion in enteroendocrine cells., [RefSeq, PubMed]; GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders., [RefSeq, PubMed]; Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway., [UniProtKB, PubMed]; Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells., [RefSeq, PubMed]; This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q495H7;Q4VBN3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031210 phosphatidylcholine binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex",
        "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q8TDV5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TF65-1",
        "uniprot_id": [
            {
                "id": "GIPC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TF65",
                "type": "external"
            }
        ],
        "mass": 34354.0,
        "length": 315,
        "protein_name": "PDZ domain-containing protein GIPC2",
        "gene_name": "GIPC2",
        "organism": "Human",
        "refseq_name": "PDZ domain-containing protein GIPC2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001291654",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291654",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GIPC2",
        "gene_names_refseq": "GIPC2; SEMCAP-2; SEMCAP2",
        "protein_names_uniprotkb": "PDZ domain-containing protein GIPC2",
        "protein_names_refseq": "PDZ domain protein GIPC2; PDZ domain-containing protein GIPC2 isoform 2; PDZ domain-containing protein GIPC2; epididymis secretory sperm binding protein; semaF cytoplasmic domain associated protein 2; semaphorin cytoplasmic domain associated protein 2",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:54810)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11836570;18978678;27862975;29557506;30379171;31154438;33947839;33968037;35051231;35347223;35580925;36241641",
        "class_list": "",
        "function": "GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling., [RefSeq, PubMed]; GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IYD3;Q9NXS7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8TF65-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92847-1",
        "uniprot_id": [
            {
                "id": "GHSR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92847",
                "type": "external"
            }
        ],
        "mass": 41329.0,
        "length": 366,
        "protein_name": "Growth hormone secretagogue receptor type 1",
        "gene_name": "GHSR",
        "organism": "Human",
        "refseq_name": "growth hormone secretagogue receptor type 1 isoform 1b",
        "refseq_ac": [
            {
                "id": "NP_004113",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004113",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GHSR",
        "gene_names_refseq": "GHDP; GHS-R1a; GHSR-1a; GHSR",
        "protein_names_uniprotkb": "Growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; GHRP; GHS-R; Ghrelin receptor",
        "protein_names_refseq": "GH-releasing peptide receptor; GHRP; GHS-R; ghrelin receptor; growth hormone secretagogue receptor type 1 isoform 1b; growth hormone secretagogue receptor type 1",
        "tax_id": 9606,
        "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); multiple endocrine neoplasia (Disease Ontology:DOID:3125); middle cerebral artery infarction (Disease Ontology:DOID:3525); obesity (Disease Ontology:DOID:9970); short stature due to GHSR deficiency (MONDO:MONDO:0014403)",
        "pathway": " (hsa:2693);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 129,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11356716;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;16511605;1655761;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;19789204;23446738;23690594;24906252;2649896;27496565;2841328;3086311;3202875;3366244;35016882;35027551;35051231;3525564;35446515;36888769;38473968;3856870;38771494;39833471;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8688086;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "A case control study investigating the methylation levels of GHRL and GHSR genes in alcohol use disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (PubMed:35027551, PubMed:39833471). Upon activation, stimulates appetite and promotes growth hormone secretion (PubMed:11322507, PubMed:10604470, PubMed:35027551, PubMed:39833471). Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692, 429, MK-0677, adenosine) (PubMed:11322507, PubMed:10604470)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; MiR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Serotonin, ghrelin, and motilin gene/receptor/transporter polymorphisms in childhood functional constipation. Publication Status: Online-Only, [RefSeq, PubMed]; The 1b variant may not be functional, it only encodes 5 of the 7 transmembrane domains and fails to respond in xenopus oocytes., [RefSeq, PubMed]; Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review. Review article, [RefSeq, PubMed]; This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14D12;Q6ISR8;Q92848;Q96RJ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0017046 peptide hormone binding;GO:0001616 growth hormone secretagogue receptor activity;GO:0016520 growth hormone-releasing hormone receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0098794 postsynapse",
        "go_biological_process": "GO:0060123 regulation of growth hormone secretion;GO:1903672 positive regulation of sprouting angiogenesis;GO:0032100 positive regulation of appetite;GO:0120058 positive regulation of small intestinal transit;GO:1904000 positive regulation of eating behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "Q92847-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96P66-1",
        "uniprot_id": [
            {
                "id": "GP101_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96P66",
                "type": "external"
            }
        ],
        "mass": 56716.0,
        "length": 508,
        "protein_name": "Probable G protein-coupled receptor 101",
        "gene_name": "GPR101",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 101",
        "refseq_ac": [
            {
                "id": "NP_473362",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473362",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR101",
        "gene_names_refseq": "GPCR6; GPR101; PAGH2; PITA2",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 101",
        "protein_names_refseq": "probable G-protein coupled receptor 101",
        "tax_id": 9606,
        "disease": "growth hormone secreting pituitary adenoma 2 (Disease Ontology:DOID:0112007)",
        "pathway": " (hsa:83550)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11574155;12044878;25470569;29557506;31793912;31848261;32958754;37217939;38006624",
        "class_list": "",
        "function": "Findings demonstrate a fundamental role for GPR101 in mediating the leukocyte-directed actions of RvD5n-3 DPA., [RefSeq, PubMed]; GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11. Publication Status: Online-Only, [RefSeq, PubMed]; GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JSM8;Q8NG93",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex",
        "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q96P66-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96P67-1",
        "uniprot_id": [
            {
                "id": "GPR82_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96P67",
                "type": "external"
            }
        ],
        "mass": 38409.0,
        "length": 336,
        "protein_name": "Probable G protein-coupled receptor 82",
        "gene_name": "GPR82",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 82",
        "refseq_ac": [
            {
                "id": "NP_543007",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543007",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR82",
        "gene_names_refseq": "GPR82",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 82",
        "protein_names_refseq": "probable G-protein coupled receptor 82",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27197)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11574155;12044878;32488085;32938616",
        "class_list": "",
        "function": "Orphan receptor., [UniProtKB]; The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VT13",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q96P67-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BZJ7-1",
        "uniprot_id": [
            {
                "id": "GPR62_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BZJ7",
                "type": "external"
            }
        ],
        "mass": 37614.0,
        "length": 368,
        "protein_name": "G protein-coupled receptor 62",
        "gene_name": "GPR62",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 62",
        "refseq_ac": [
            {
                "id": "NP_543141",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543141",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR62",
        "gene_names_refseq": "GPCR8; GPR62; KPG_005",
        "protein_names_uniprotkb": "G protein-coupled receptor 62; G protein-coupled receptor GPCR8; G protein-coupled receptor KPG_005; hGPCR8",
        "protein_names_refseq": "G-protein coupled receptor 62; G-protein coupled receptor GPCR8; G-protein coupled receptor KPG_005; hGPCR8; probable G-protein coupled receptor 62",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:118442)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11165367;12044878;24715725;28827538;31154438;31217245;32938616;35318648",
        "class_list": "",
        "function": "Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan G protein-coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538)., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F1DAM4;Q5KU27",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:1990763 arrestin family protein binding",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0050850 positive regulation of calcium-mediated signaling;GO:0038035 ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9BZJ7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9GZN0-1",
        "uniprot_id": [
            {
                "id": "GPR88_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9GZN0",
                "type": "external"
            }
        ],
        "mass": 40246.0,
        "length": 384,
        "protein_name": "G protein-coupled receptor 88",
        "gene_name": "GPR88",
        "organism": "Human",
        "refseq_name": "G protein-coupled receptor 88",
        "refseq_ac": [
            {
                "id": "NP_071332",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071332",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR88; STRG",
        "gene_names_refseq": "COCPMR; GPR88; STRG",
        "protein_names_uniprotkb": "G protein-coupled receptor 88; Striatum-specific G protein-coupled receptor",
        "protein_names_refseq": "G protein-coupled receptor 88; probable G-protein coupled receptor 88; striatum-specific G-protein coupled receptor",
        "tax_id": 9606,
        "disease": "chorea, childhood-onset, with psychomotor retardation (MONDO:MONDO:0014839)",
        "pathway": " (hsa:54112)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11056049;23936473;27123486;27499251;29393594;29557506;31844290;31848261;32938616;35501348;36075963",
        "class_list": "",
        "function": "Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Study designed and synthesized a series of 2-PCCA analogues bearing a variety of substituents at the phenyl ring of the aniline moiety to determine the structure-activity relationship (SAR) in this region; SAR studies suggested that there is a hydrophobic pocket in the GPR88 binding site interacting with the aniline region of 2-PCCA, [RefSeq, PubMed]; The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder., [RefSeq, PubMed]; The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q29S24;Q6VN48",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004941 beta2-adrenergic receptor activity;GO:0003774 cytoskeletal motor activity;GO:0008020 G protein-coupled photoreceptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0060170 ciliary membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0061743 motor learning;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9GZN0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HC44-1",
        "uniprot_id": [
            {
                "id": "GPBL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HC44",
                "type": "external"
            }
        ],
        "mass": 52302.0,
        "length": 474,
        "protein_name": "Vasculin-like protein 1",
        "gene_name": "GPBP1L1",
        "organism": "Human",
        "refseq_name": "vasculin-like protein 1",
        "refseq_ac": [
            {
                "id": "NP_067652",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067652",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPBP1L1; SP192",
        "gene_names_refseq": "GPBP1L1; SP192",
        "protein_names_uniprotkb": "Vasculin-like protein 1; GC-rich promoter-binding protein 1-like 1",
        "protein_names_refseq": "vasculin-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:60313)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "15498874;18220336;18669648;19651622;19690332;21406692;23186163;23301498;23481700;25576301;27846572;27920218;28832583;28904123;29242379;29493099;30379171;30429286;31217245;31844290;32157095;32387766;32938616;33968037;36010968",
        "class_list": "",
        "function": "Possible transcription factor., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQ10;Q9H751",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9HC44-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HC97-1",
        "uniprot_id": [
            {
                "id": "GPR35_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HC97",
                "type": "external"
            }
        ],
        "mass": 34072.0,
        "length": 309,
        "protein_name": "G protein-coupled receptor 35",
        "gene_name": "GPR35",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 35 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001182310",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182310",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR35",
        "gene_names_refseq": "GPR35",
        "protein_names_uniprotkb": "G protein-coupled receptor 35; KYNA receptor; Kynurenic acid receptor",
        "protein_names_refseq": "G-protein coupled receptor 35 isoform b; KYNA receptor; kynurenic acid receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2859);  (R-HSA-373076)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "11017071;12522134;12524422;12955148;14617636;15141213;15280385;15326175;15929991;16540462;1656963;16754668;16844083;17139494;17339491;17462861;17876302;18588883;19473985;20361937;21796212;2263478;24347166;24715725;25411203;25880248;28446606;29068046;29242379;29557506;29875152;31530632;31848261;32357974;32387766;32983136;33043033;34087483;35051231;35101446;35148838;35926043;36543774;36614059;36637186;37217939;37227682;37660910;38035084;7498464;7568007;7689702;7775459;7946354;9479505",
        "class_list": "",
        "function": "G protein-coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:16754668, PubMed:19473985, PubMed:20361937, PubMed:24347166, PubMed:35148838, PubMed:35926043). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:19473985, PubMed:35926043). GPR35 can couple with G(i)/G(o)- or G(12)/G(13) classes of G alpha proteins depending on the context, mediating the inhibition of adenylate cyclase or activation Rho small GTPases, respectively (PubMed:19473985, PubMed:35926043, PubMed:36543774). KYNA-binding promotes monocyte adhesion to vascular endothelium under flow conditions, leading to G(i)/GNAI1 activation and inhibition of adenylate cyclase (PubMed:19473985). Involved in cardioprotection during ischemia by promoting mitochondrial remodeling: following KYNA-binding and G(i)/GNAI1 activation, GPR35 is internalized to the outer mitochondrial membrane, where it inhibits mitochondrial adenylate cyclase (ADCY10), allowing ATPIF1 to repress ATP synthase activity (PubMed:35926043). Stimulates lipid metabolism, thermogenic and anti-inflammatory gene expression in adipose tissue once activated by KYNA (By similarity). Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand (PubMed:35148838). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation (By similarity). In turn, induces chemotaxis of macrophages (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; GPR35 acts a dual role and therapeutic target in inflammation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Increased GPR35 expression in human colorectal and pancreatic cancer samples: A preliminary clinical validation of a new biomarker., [RefSeq, PubMed]; Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and Progression. Publication Status: Online-Only, [RefSeq, PubMed]; Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J3KR30;O43495;Q17R58;Q4VBN5;Q4ZFV2;Q6FHI8;Q86UH4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004950 chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002931 response to ischemia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0070098 chemokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q9HC97-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQS5-1",
        "uniprot_id": [
            {
                "id": "GPR84_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQS5",
                "type": "external"
            }
        ],
        "mass": 43705.0,
        "length": 396,
        "protein_name": "G protein-coupled receptor 84",
        "gene_name": "GPR84",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 84",
        "refseq_ac": [
            {
                "id": "NP_065103",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065103",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR84; EX33",
        "gene_names_refseq": "EX33; GPCR4; GPR84",
        "protein_names_uniprotkb": "G protein-coupled receptor 84; Inflammation-related G protein-coupled receptor EX33",
        "protein_names_refseq": "G-protein coupled receptor 84; inflammation-related G protein-coupled receptor EX33",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53831);  (R-HSA-418555);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 72,
        "publication_id_list": "11007482;11273702;11404393;12036966;12044878;12058044;12106601;12180353;12860470;13549488;14671004;1517224;15765929;15769620;15951850;16313925;16687412;16923326;16966319;17168849;18044684;18577758;19105585;19876791;19929708;20381629;21036126;2163110;23033978;23650620;2417744;24687066;2491850;2553411;2553705;26417854;2871555;29242379;29443750;29557506;29602314;30620550;30833991;3127824;31279028;31399091;31983287;32226383;32497535;32540603;32618402;32715661;32983136;33049737;33789297;33912179;34171305;34357683;35051231;35427647;36869866;37085331;37533166;37543157;6085243;8340388;8514797;8672451;8692836;9263355;9417641;9651336",
        "class_list": "",
        "function": "Function and regulation of GPR84 in human neutrophils. Review article, [RefSeq, PubMed]; G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (PubMed:16966319). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Also plays an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:33789297)., [UniProtKB, UniProtKB, PubMed, PubMed]; GPR84 in physiology-Many functions in many tissues. Review article, [RefSeq, PubMed]; Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84., [RefSeq, PubMed]; Regulation of the pro-inflammatory G protein-coupled receptor GPR84. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B6V9G7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001604 urotensin II receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0043235 receptor complex;GO:0070821 tertiary granule membrane",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9NQS5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NS67-1",
        "uniprot_id": [
            {
                "id": "GPR27_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NS67",
                "type": "external"
            }
        ],
        "mass": 39818.0,
        "length": 375,
        "protein_name": "Probable G protein-coupled receptor 27",
        "gene_name": "GPR27",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 27",
        "refseq_ac": [
            {
                "id": "NP_061844",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061844",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR27; SREB1",
        "gene_names_refseq": "GPR27; SREB1",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 27; Super conserved receptor expressed in brain 1",
        "protein_names_refseq": "probable G-protein coupled receptor 27; super conserved receptor expressed in brain 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2850);  (R-HSA-418555)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10833454;11007482;12036966;12058044;12106601;12180353;12860470;13549488;14671004;1517224;15765929;15769620;15951850;16313925;16687412;16923326;17168849;18044684;18577758;19105585;19876791;19929708;20381629;21036126;2163110;2417744;24687066;2491850;2553411;2553705;26417854;2871555;29242379;29443750;29602314;30429286;30833991;31154438;3127824;31279028;31399091;31983287;32226383;32497535;32540603;32618402;32715661;32897882;33049737;35051231;35580925;37702614;38638156;6085243;8340388;8514797;8672451;9263355;9417641;9651336",
        "class_list": "",
        "function": "GPR27 expression correlates with prognosis and tumor progression in gliomas. Publication Status: Online-Only, [RefSeq, PubMed]; GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]., [RefSeq]; Orphan receptor. Possible candidate for amine-like G protein coupled receptor., [UniProtKB]; Prognostic significance and immune characteristics of GPR27 in gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q9NS67-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZD1-1",
        "uniprot_id": [
            {
                "id": "GPC5D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZD1",
                "type": "external"
            }
        ],
        "mass": 38791.0,
        "length": 345,
        "protein_name": "G protein-coupled receptor family C group 5 member D",
        "gene_name": "GPRC5D",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor family C group 5 member D",
        "refseq_ac": [
            {
                "id": "NP_061124",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061124",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPRC5D",
        "gene_names_refseq": "GPRC5D",
        "protein_names_uniprotkb": "G protein-coupled receptor family C group 5 member D",
        "protein_names_refseq": "G-protein coupled receptor family C group 5 member D; orphan G-protein coupled receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55507)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11311935;12044878;15086536;20424473;22591013;23510526;34509645;37574551;37653140;37819961;38307865;38898050;39181182",
        "class_list": "",
        "function": "Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation. Erratum:[Nat Cancer. 2023 Nov;4(11):1610. doi: 10.1038/s43018-023-00646-4. PMID: 37684528], [RefSeq, PubMed]; G protein-coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails., [UniProtKB, PubMed]; GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review. Review article Erratum:[Blood Cancer J. 2024 Mar 6;14(1):40. doi: 10.1038/s41408-024-01018-6. PMID: 38448422] Publication Status: Online-Only, [RefSeq, PubMed]; GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies., [RefSeq, PubMed]; Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma., [RefSeq, PubMed]; The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KNV3;Q7Z5J9;Q8TDS6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030295 protein kinase activator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9NZD1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UPC5-1",
        "uniprot_id": [
            {
                "id": "GPR34_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UPC5",
                "type": "external"
            }
        ],
        "mass": 43860.0,
        "length": 381,
        "protein_name": "Probable G protein-coupled receptor 34",
        "gene_name": "GPR34",
        "organism": "Human",
        "refseq_name": "probable G-protein coupled receptor 34",
        "refseq_ac": [
            {
                "id": "NP_001091048",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091048",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR34",
        "gene_names_refseq": "GPR34; LPS1; LYPSR1",
        "protein_names_uniprotkb": "Probable G protein-coupled receptor 34",
        "protein_names_refseq": "lysophosphatidylserine receptor 1; probable G-protein coupled receptor 34",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2857)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10036181;10395919;10982042;16338117;16460680;27086875;28514659;29393594;31848261;37733739;38048360;38326347;39358444",
        "class_list": "",
        "function": "Cryo-EM structures of human GPR34 enable the identification of selective antagonists., [RefSeq, PubMed]; Data show that multiple translation initiation starts and alternative splicing contribute to the supragenomic diversification of GPR34, [RefSeq, PubMed]; G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]., [RefSeq]; GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity. Erratum:[Nat Immunol. 2024 Nov;25(11):2167. doi: 10.1038/s41590-024-02001-w. PMID: 39375551], [RefSeq, PubMed]; Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174. Publication Status: Online-Only, [RefSeq, PubMed]; Structural basis for lysophosphatidylserine recognition by GPR34. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95853",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9UPC5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2T5-1",
        "uniprot_id": [
            {
                "id": "GPR52_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2T5",
                "type": "external"
            }
        ],
        "mass": 41354.0,
        "length": 361,
        "protein_name": "G protein-coupled receptor 52",
        "gene_name": "GPR52",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 52",
        "refseq_ac": [
            {
                "id": "NP_005675",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005675",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR52",
        "gene_names_refseq": "GPR52",
        "protein_names_uniprotkb": "G protein-coupled receptor 52",
        "protein_names_refseq": "G-protein coupled receptor 52; probable G-protein coupled receptor 52",
        "tax_id": 9606,
        "disease": "renal fibrosis (Disease Ontology:DOID:0050855); alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:9293)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "24587241;25738228;29557506;32076264;32519845;33258587;35051231;9931487",
        "class_list": "",
        "function": "Beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons., [RefSeq, PubMed]; Data show that G protein-coupled receptor 52 (Gpr52) modulates huntingtin protein (Htt) levels in the striatal cells in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228)., [UniProtKB, PubMed, PubMed]; High-resolution structures of human GPR52 in three states: a ligand-free state, a Gs-coupled self-activation state and a potential allosteric ligand-bound state, [RefSeq, PubMed]; Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002]., [RefSeq]; Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75654;Q4VBL6;Q6ISM0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008020 G protein-coupled photoreceptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0009410 response to xenobiotic stimulus;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9Y2T5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5QNW6-1",
        "uniprot_id": [
            {
                "id": "H2B2F_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5QNW6",
                "type": "external"
            }
        ],
        "mass": 13920.0,
        "length": 126,
        "protein_name": "Histone H2B type 2-F",
        "gene_name": "H2BC18",
        "organism": "Human",
        "refseq_name": "histone H2B type 2-F isoform a",
        "refseq_ac": [
            {
                "id": "NP_001019770",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019770",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC18; HIST2H2BF",
        "gene_names_refseq": "H2BC18; HIST2H2BF",
        "protein_names_uniprotkb": "Histone H2B type 2-F; H2B-clustered histone 18",
        "protein_names_refseq": "histone H2B type 2-F isoform a; histone H2B type 2-F; histone cluster 2 H2B family member f; histone cluster 2, H2bf",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440689);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-5689880);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9918481)",
        "pathway_count": 7,
        "publication_count": 167,
        "publication_id_list": "10444327;10444591;10449787;10748112;10786633;10821277;10904264;10922406;10926844;10982817;11466336;11509652;11566882;11739383;11742974;11747608;11909966;11923872;12032298;12724404;12757711;12857923;12917689;12917691;14519844;14661020;14762106;15053880;15084397;15313887;15916963;16140760;16214042;16283522;16307923;16319397;16387653;16713563;16901786;16964248;17211407;17290220;17443180;17873522;17980597;17981138;18172164;18203656;18381289;18467330;18535146;18623064;18632802;18636086;19015242;19135894;19187765;19188362;19363159;19398555;19424180;19531498;19608861;19640981;19682613;19838211;19874889;19910467;20018852;20096447;20228808;20368735;20501646;21239494;21362556;21571647;21587264;21596315;21659512;21690215;21726816;21849505;21896475;21911577;21925322;21962518;22029577;22085928;22128162;22174689;22216260;22389435;23159851;23395819;23481700;23486064;23824326;23825189;24056413;24260525;24366607;24493797;24681537;24896179;25197364;25305019;25418920;25578727;25645385;25802875;25892735;26092250;26101246;26375851;26552660;26572645;26758079;26929215;27105113;27105115;27108190;27452731;27501258;27543614;27600516;28218747;28228285;28415052;28514659;28649982;28832583;28834231;29242379;29393594;29493099;29508533;29632711;29769354;29786170;29789417;29902443;30154464;30192525;30315122;30360396;30444036;30524438;30599162;30761409;31542297;31611695;31645732;32119511;33177556;34545082;34874266;34961760;35215846;37217939;7513682;7578059;9150135;9427644;9558366;9651585;9790534;9880483",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0U9;B4DLA9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 17.0,
        "record_id": "Q5QNW6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43172-1",
        "uniprot_id": [
            {
                "id": "PRP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43172",
                "type": "external"
            }
        ],
        "mass": 58449.0,
        "length": 522,
        "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4",
        "gene_name": "PRPF4",
        "organism": "Human",
        "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001231855",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231855",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRPF4; PRP4",
        "gene_names_refseq": "HPRP4P; HPRP4; PRP4; PRPF4; Prp4p; RP70; SNRNP60",
        "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp4; PRP4 homolog; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4; hPrp4",
        "protein_names_refseq": "PRP4 homolog; PRP4 pre-mRNA processing factor 4 homolog; PRP4/STK/WD splicing factor; U4/U6 small nuclear ribonucleoprotein Prp4 isoform 2; U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4; pre-mRNA processing factor 4",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 70 (Disease Ontology:DOID:0110392); retinitis pigmentosa (Disease Ontology:DOID:10584)",
        "pathway": " (hsa:9128);  (R-HSA-72163)",
        "pathway_count": 2,
        "publication_count": 142,
        "publication_id_list": "10.1101/2023.09.13.557529;10882114;11014198;11101529;11233976;11991638;12176931;12411573;12414731;12477934;12875835;14625303;14713954;16314458;16723661;16809785;17095540;17332742;17606899;18322460;18593880;19103666;19165350;19536130;19608861;20068231;20423332;20980672;21536652;2176635;22110043;22365833;22959432;22961380;23222130;23236153;23345524;23481700;23783831;24196718;24304693;24419317;24448447;24715725;24737827;24914973;25383878;25418920;25555158;25576301;2558966;26030138;26375851;26385511;26420826;26912367;26969736;26992070;27377154;27459055;27600516;27683217;28062851;28076346;28218747;28352266;28502770;28510447;28781166;28832583;28904123;29242379;29301961;29331515;29360106;29361316;29437277;29493099;29557506;2963332;30315122;30315277;30379171;30397120;30429286;30705154;30728453;30765414;30975767;31217245;31409651;31445970;31844290;31848261;31998317;32157095;32179686;32329775;32357974;32387766;32494006;32938616;32983136;33141586;33214551;33243851;33298915;33446560;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34301950;34561969;34822310;35051231;35385551;35561310;35580925;37217939;3757028;37938771;38665916;40596516;40914422;8566756;8608946;9000057;9016565;9242493;9257651;9328476;9404889;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, PubMed, PubMed]; Results confirmed that the PRPF4 gene was overexpressed in various breast cancer cell lines. Its knockdown slows down breast cancer progression via suppression of p38 MAPK phosphorylation. In conclusion, the PRPF4 gene plays an important role in the growth of breast cancer cells., [RefSeq, PubMed]; The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43445;O43864;Q5T1M8;Q96DG2;Q96IK4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0017070 U6 snRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body",
        "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006396 RNA processing;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 14.7,
        "record_id": "O43172-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95171-1",
        "uniprot_id": [
            {
                "id": "SCEL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95171",
                "type": "external"
            }
        ],
        "mass": 77552.0,
        "length": 688,
        "protein_name": "Sciellin",
        "gene_name": "SCEL",
        "organism": "Human",
        "refseq_name": "sciellin isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001154178",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154178",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCEL",
        "gene_names_refseq": "SCEL",
        "protein_names_uniprotkb": "Sciellin",
        "protein_names_refseq": "sciellin isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8796)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;14632196;15274303;28514659;29242379;29331515;29485866;29557506;29741879;30429286;31848261;31974341;32157095;35051231;35580925;36284347;37060824;37733753;38253038;38411346;9813070",
        "class_list": "",
        "function": "CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL., [RefSeq, PubMed]; Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer., [RefSeq, PubMed]; Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing. Publication Status: Online-Only, [RefSeq, PubMed]; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope., [UniProtKB]; Sciellin promotes the development and progression of thyroid cancer through the JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis., [RefSeq, PubMed]; The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; VDUP1 and sciellin were more highly expressed in keratinocytes undergoing differentiation and colocalization of the proteins could be demonstrated, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z797;F5H651;Q53H61;Q5W0S8;Q5W0S9;Q86X00",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0009612 response to mechanical stimulus;GO:0090263 positive regulation of canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O95171-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZVD7-1",
        "uniprot_id": [
            {
                "id": "STOX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZVD7",
                "type": "external"
            }
        ],
        "mass": 110962.0,
        "length": 989,
        "protein_name": "Storkhead-box protein 1",
        "gene_name": "STOX1",
        "organism": "Human",
        "refseq_name": "storkhead-box protein 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001123631",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123631",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "STOX1; C10orf24",
        "gene_names_refseq": "C10orf24; STOX1",
        "protein_names_uniprotkb": "Storkhead-box protein 1; Winged-helix domain-containing protein",
        "protein_names_refseq": "storkhead-box protein 1 isoform b; storkhead-box protein 1; winged-helix domain-containing protein",
        "tax_id": 9606,
        "disease": "pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:219736)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;15806103;17290274;17617193;19079545;22253775;22995177;23481700;24715725;24738702;27535533;30418433;31092671;31154438;32502341;32807495;32938616;32983136;33356399;33968037;34171305;35051231;35494241;36010968;36241641;36369889;36555567",
        "class_list": "",
        "function": "Anomalies in STOX1 expression are associated with the onset of preeclampsia., [RefSeq, PubMed]; Circ-ZUFSP regulates trophoblasts migration and invasion through sponging miR-203 to regulate STOX1 expression., [RefSeq, PubMed]; Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth., [RefSeq, PubMed]; In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177)., [UniProtKB, PubMed, PubMed]; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; Modeling Preeclampsia In Vitro: Polymorphic Variants of STOX1-A/B Genes Can Downregulate CD24 in Trophoblast Cell Lines. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; STOX1 promotor region -922 T > C polymorphism is associated with Early-Onset preeclampsia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3Q9;A5D6Y7;B0QZA4;B0QZA5;B0QZA6;Q4F8Q6;Q5I946;Q5I947;Q5I948;Q5VX38;Q5VX39;Q6ZRY3;Q96LR3;Q96LS0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0010800 positive regulation of peptidyl-threonine phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q6ZVD7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TE12-1",
        "uniprot_id": [
            {
                "id": "LMX1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TE12",
                "type": "external"
            }
        ],
        "mass": 42747.0,
        "length": 382,
        "protein_name": "LIM homeobox transcription factor 1-alpha",
        "gene_name": "LMX1A",
        "organism": "Human",
        "refseq_name": "LIM homeobox transcription factor 1-alpha",
        "refseq_ac": [
            {
                "id": "NP_001167540",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167540",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LMX1A",
        "gene_names_refseq": "DFNA7; LMX1.1; LMX1A; LMX1",
        "protein_names_uniprotkb": "LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1.1",
        "protein_names_refseq": "LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 7 (Disease Ontology:DOID:0110591)",
        "pathway": " (hsa:4009)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "12062816;17322306;29485866;29754270;29971487;33968037;35051231;35254497;35711095;36197580;38253038;38759646",
        "class_list": "",
        "function": "Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity)., [UniProtKB]; CeRNA network of lncRNA MIR210HG/miR-377-3p/LMX1A in malignant proliferation of glioma cells., [RefSeq, PubMed]; Did not find evidence for association of any LMX1A SNPs with type 2 diabetes mellitus (T2DM) and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons., [RefSeq, PubMed]; Novel Molecular Genetic Etiology of Asymmetric Hearing Loss: Autosomal-Dominant LMX1A Variants., [RefSeq, PubMed]; This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]., [RefSeq]; Update on CD164 and LMX1A genes to strengthen their causative role in autosomal dominant hearing loss., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXP6;Q0VDB5;Q5VWG4;Q8TE11",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050808 synapse organization;GO:0030182 neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8TE12-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P62304-1",
        "uniprot_id": [
            {
                "id": "RUXE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P62304",
                "type": "external"
            }
        ],
        "mass": 10804.0,
        "length": 92,
        "protein_name": "Small nuclear ribonucleoprotein E",
        "gene_name": "SNRPE",
        "organism": "Human",
        "refseq_name": "small nuclear ribonucleoprotein E isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001291393",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291393",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SNRPE",
        "gene_names_refseq": "HYPT11; SME; SNRPE; Sm-E; snRNP-E",
        "protein_names_uniprotkb": "Small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E",
        "protein_names_refseq": "sm protein E; small nuclear ribonucleoprotein E isoform 2",
        "tax_id": 9606,
        "disease": "lupus nephritis (Disease Ontology:DOID:0080162); hypotrichosis 1 (Disease Ontology:DOID:0110698); hypotrichosis 11 (Disease Ontology:DOID:0110708); prostate cancer (Disease Ontology:DOID:10283); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:6635);  (R-HSA-111367);  (R-HSA-191859);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-73856);  (R-HSA-77588);  (R-HSA-9754678);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 11,
        "publication_count": 246,
        "publication_id_list": "10.1101/2023.09.13.557529;10199952;10207048;10500148;10531003;10556282;10601333;10669729;10725331;10851237;10882114;11014198;11060040;11101529;11233976;11237011;11333016;11333026;11574479;11607023;11714716;11747608;11748230;11991638;12065586;12095920;12176931;12411573;12414731;12441251;12477934;12682017;12776181;12975319;14519844;14625303;14713954;14749727;14762106;14978097;15037765;15084397;15146077;15565158;15647753;16263726;16314458;16314521;16372014;16809785;17095540;17128255;17332742;17433364;17606899;17717186;17940139;18042460;18288197;18322460;18593880;18984161;19052544;19103666;19165350;19217410;19325628;19536130;19838190;20112406;20211137;20423332;20695905;20980672;21295486;21516107;21536652;2176635;21816274;21911577;22046413;22110043;22121020;22365833;22569126;22813749;22922743;22959432;22961380;23222130;23236153;23246290;23333303;23345524;23481700;23874216;24076191;24149845;24196718;24304693;2440864;24448447;24714562;24715725;24737827;24914973;2524422;25301780;25301781;25418920;25555158;25576301;2558966;25892735;26024233;26092250;26154972;26385511;26420826;26728094;26811146;26912367;26969736;26992070;27108190;27377154;27397612;27459055;27510544;27600516;27661449;27683217;27846572;28062851;28076346;28096519;28228285;28502770;28510447;28781166;28832583;28904123;28911096;29186539;29274231;29301961;29360106;29361316;29393594;29493099;29557506;29632046;29632711;2963332;2972723;2974536;29786170;29902443;30139799;30192525;30257008;30315122;30315277;30410026;30524438;30599162;30705154;30728453;30765414;30779550;30975767;31222486;31409651;31799625;31844290;31848261;32161166;32179686;32329775;32350084;32387766;32494006;32680882;32816001;32897882;32908316;32938616;32983136;32995776;32995777;33080218;33141586;33177556;33188728;33214551;33243851;33268501;33392160;33446560;33479166;33717175;33912179;33936100;34019948;34087483;34301950;34315815;34373319;34509645;34561969;34624207;34822310;35051231;35083852;35138101;35177536;35215846;35251023;35385551;35580925;36215666;36241641;36284347;36581221;36610391;36797247;3757028;37938771;38665916;38796598;40930100;8196654;8566756;8608946;8835860;9016565;9049306;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529;9845364",
        "class_list": "",
        "function": "Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23246290, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 9,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5B9;P08578;Q15498;Q5BKT2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex",
        "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 25.1,
        "record_id": "P62304-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P57086-1",
        "uniprot_id": [
            {
                "id": "SCND1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P57086",
                "type": "external"
            }
        ],
        "mass": 19082.0,
        "length": 179,
        "protein_name": "SCAN domain-containing protein 1",
        "gene_name": "SCAND1",
        "organism": "Human",
        "refseq_name": "SCAN domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_057642",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057642",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCAND1; SDP1",
        "gene_names_refseq": "RAZ1; SCAND1; SDP1",
        "protein_names_uniprotkb": "SCAN domain-containing protein 1",
        "protein_names_refseq": "SCAN domain-containing protein 1; SCAN-related protein RAZ1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51282)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "10747874;16112985;16540086;20058876;22544926;23481700;24715725;25576301;26154972;26992070;27846572;27862975;29493099;29557506;30429286;31154438;31222486;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33912179;33936100;33968037;33981976;34171305;34211107;34405274;34509645;34561969;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36241641;36284347;36552758",
        "class_list": "",
        "function": "May regulate transcriptional activity., [UniProtKB]; SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and Migration. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]., [RefSeq]; This result indicates that NY-REN-21 can function either as a homodimer or as a heterodimer with SCAND1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAG7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "P57086-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HCK0-1",
        "uniprot_id": [
            {
                "id": "ZBT26_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HCK0",
                "type": "external"
            }
        ],
        "mass": 49953.0,
        "length": 441,
        "protein_name": "Zinc finger and BTB domain-containing protein 26",
        "gene_name": "ZBTB26",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 26",
        "refseq_ac": [
            {
                "id": "NP_001291292",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291292",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZBTB26; KIAA1572; ZNF481",
        "gene_names_refseq": "ZBTB26; ZNF481; bioref",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 26; Zinc finger protein 481; Zinc finger protein Bioref",
        "protein_names_refseq": "zinc finger and BTB domain-containing protein 26; zinc finger protein 481; zinc finger protein 483; zinc finger protein Bioref",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57684)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "23481700;24714562;26728094;29557506;31844290;32938616;33298915;34946811;36241641;37217939",
        "class_list": "",
        "function": "Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQ53;Q8WTR1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9HCK0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13163-1",
        "uniprot_id": [
            {
                "id": "MP2K5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13163",
                "type": "external"
            }
        ],
        "mass": 50112.0,
        "length": 448,
        "protein_name": "Dual specificity mitogen-activated protein kinase kinase 5",
        "gene_name": "MAP2K5",
        "organism": "Human",
        "refseq_name": "dual specificity mitogen-activated protein kinase kinase 5 isoform C",
        "refseq_ac": [
            {
                "id": "NP_001193733",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193733",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAP2K5; MEK5; MKK5; PRKMK5",
        "gene_names_refseq": "HsT17454; MAP2K5; MAPKK5; MEK5; PRKMK5",
        "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 5; 2.7.12.2; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5",
        "protein_names_refseq": "MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MEK 5; dual specificity mitogen-activated protein kinase kinase 5 isoform C; dual specificity mitogen-activated protein kinase kinase 5",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:5607);  (R-HSA-198765)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "11237011;11544482;12628002;16728640;17344846;18691976;19369195;25418920;25469497;25892735;26758079;26811146;27846572;27920218;28063628;28218747;28514659;28639275;28832583;29242379;29393594;29557506;29632046;29769354;30315122;30524438;31154438;31844290;32157095;32387766;32897882;33592498;34245854;34681917;35051231;35713705;36010968;36968222;37278562;37938771;7759517;9384584",
        "class_list": "",
        "function": "Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation., [RefSeq, PubMed]; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis., [RefSeq, PubMed]; MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival., [RefSeq, PubMed]; The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 14,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DE43;Q92961;Q92962",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005819 spindle",
        "go_biological_process": "GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0070375 ERK5 cascade;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q13163-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60636-1",
        "uniprot_id": [
            {
                "id": "TSN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60636",
                "type": "external"
            }
        ],
        "mass": 24148.0,
        "length": 221,
        "protein_name": "Tetraspanin-2",
        "gene_name": "TSPAN2",
        "organism": "Human",
        "refseq_name": "tetraspanin-2 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001295245",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295245",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TSPAN2",
        "gene_names_refseq": "NET3; TSN2; TSPAN-2; TSPAN2",
        "protein_names_uniprotkb": "Tetraspanin-2; Tetraspan NET-3; Tspan-2",
        "protein_names_refseq": "new EST tetraspan 3; tetraspan 2; tetraspan NET-3; tetraspan TM4SF; tetraspanin-2 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10100)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;20237496;23294458;28408487;29198723;31154438;31823250;32387766;35580925;9714763",
        "class_list": "",
        "function": "May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Studies suggest that TSPAN2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions. [review] Review article, [RefSeq, PubMed]; The C-allele of rs2078371 near TSPAN-2 also reached genome-wide significance for association with migraine., [RefSeq, PubMed]; The authors have identified TSPAN2 as a candidate gene for Blood Pressure Regulation that is regulated by heritable DNA methylation, [RefSeq, PubMed]; The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]; Transmigration of Tetraspanin 2 (Tspan2) siRNA Via Microglia Derived Exosomes across the Blood Brain Barrier Modifies the Production of Immune Mediators by Microglia Cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6PTH4;Q5TET2;Q8WU05",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043209 myelin sheath",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "O60636-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15746-1",
        "uniprot_id": [
            {
                "id": "MYLK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15746",
                "type": "external"
            }
        ],
        "mass": 210715.0,
        "length": 1914,
        "protein_name": "Myosin light chain kinase, smooth muscle",
        "gene_name": "MYLK",
        "organism": "Human",
        "refseq_name": "myosin light chain kinase, smooth muscle isoform 9",
        "refseq_ac": [
            {
                "id": "NP_001308238",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308238",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYLK; MLCK1; MLCK; MYLK1",
        "gene_names_refseq": "AAT7; KRP; MLCK108; MLCK1; MLCK210; MLCK; MMIHS1; MMIHS; MSTP083; MYLK-L; MYLK1; MYLK; smMLCK",
        "protein_names_uniprotkb": "Myosin light chain kinase, smooth muscle; 2.7.11.18; KRP; Kinase-related protein; MLCK; Telokin; smMLCK",
        "protein_names_refseq": "kinase-related protein; myosin light chain kinase, smooth muscle isoform 9; myosin, light polypeptide kinase; smooth muscle myosin light chain kinase; telokin",
        "tax_id": 9606,
        "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); adult respiratory distress syndrome (Disease Ontology:DOID:11394); thoracic aortic aneurysm (Disease Ontology:DOID:14004); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393)",
        "pathway": " (hsa:4638);  (R-HSA-445355);  (R-HSA-5627123)",
        "pathway_count": 3,
        "publication_count": 141,
        "publication_id_list": "10047984;10092231;10198165;10470034;10536370;10639334;10748018;10975528;10991994;11113114;11237011;11242081;11278486;11346659;11457814;11532985;11804587;11889009;11976941;12048254;12198493;12408982;12453877;14506282;14580336;14627618;14741352;15000491;15020676;15310280;15377279;15378014;15507455;156362;15750850;15825080;16204230;16284075;16723733;16835238;16854367;17055381;17344846;18088087;18318008;18462678;18587400;18710790;18829550;18974361;19011151;19289088;1930128;19380584;19413330;19429448;19513348;19651622;19826488;20053363;20058876;20139351;20166139;20181817;20375339;20444238;20453870;20861316;21055718;21098037;2160950;21918590;22015949;22421042;22778174;23161543;23834404;24166499;24275569;24714562;24859002;24872348;2526655;25576301;26154972;26362469;26992070;27397612;2764880;27679490;27846572;27862975;28401540;28602422;28741090;28832583;29393594;29544503;29557506;29632711;29786170;29789417;30429286;30620550;3079756;31844290;32157095;32488085;32938616;33592498;33912179;33936100;33968037;34087483;34171305;35051231;35278271;35537812;35580925;36010968;36170767;36284347;3780718;37938771;38081409;3839510;38665916;39468273;7547920;7559638;7711037;8107774;8575746;8858389;9160829;9481611;9535855;9598563;9600334;9683637;9855623",
        "class_list": "",
        "function": "Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease., [RefSeq, PubMed]; The SNHG12/microRNA-15b-5p/MYLK axis regulates vascular smooth muscle cell phenotype to affect intracranial aneurysm formation., [RefSeq, PubMed]; The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression., [RefSeq, PubMed]; This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 47,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DUE3;D3DN97;O95796;O95797;O95798;O95799;Q14844;Q16794;Q17S15;Q3ZCP9;Q5MY99;Q5MYA0;Q6P2N0;Q7Z4J0;Q9C0L5;Q9UBG5;Q9UBY6;Q9UIT9",
        "ec_number_list": [
            {
                "id": "3.1.3.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0097110 scaffold protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0006468 protein phosphorylation;GO:0006939 smooth muscle contraction;GO:0030335 positive regulation of cell migration;GO:0090303 positive regulation of wound healing",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "Q15746-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96NZ8-1",
        "uniprot_id": [
            {
                "id": "WFKN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96NZ8",
                "type": "external"
            }
        ],
        "mass": 58798.0,
        "length": 548,
        "protein_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1",
        "gene_name": "WFIKKN1",
        "organism": "Human",
        "refseq_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_444514",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444514",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "WFIKKN1; C16orf12; GASP2; PSEC0040; WFIKKN",
        "gene_names_refseq": "C16orf12; RJD2; WFDC20A; WFIKKN1; WFIKKN",
        "protein_names_uniprotkb": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; GASP-2; Growth and differentiation factor-associated serum protein 2; WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein; hGASP-2",
        "protein_names_refseq": "GASP-2; WAP four-disulfide core domain 20A; WAP, FS, Ig, KU, and NTR-containing protein; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor; WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing protein; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1; growth and differentiation factor-associated serum protein 2; hGASP-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:117166)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11274388;11928817;12595574;12709070;16791741;21054789;23829672;25418920;27325460;27782377;29557506;32265295;32938616;35051231",
        "class_list": "",
        "function": "Data indicate that WFIKKN proteins are antagonists of GDF8 and GDF11, but in the case of TGFbeta1, BMP2 and BMP4 they function as growth factor binding proteins, [RefSeq, PubMed]; Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity., [RefSeq, PubMed]; Data suggest that myostatin binding to its receptor (activin receptors type II) can be blocked by WFIKKN1 but not WFIKKN2; various forms of myostatin (promyostatin, myostatin pro-domain, and latent/processed myostatin) bind WFIKKN1 but not WFIKKN2., [RefSeq, PubMed]; Data suggest that the physiological target of WFIKKN protein may be trypsin., [RefSeq, PubMed]; In this review, we summarize current knowledge about the WFIKKN proteins and propose that they are 'companion' proteins for various growth factors by providing localized and sustained presentation of TGFB proteins to their respective receptors, thus regulating the balance between the activation of Smad and non-Smad pathways by TGFB. Review article, [RefSeq, PubMed]; Newly discovered WFIKKNPR gene structure and tissue distribution of gene expression is commpared with that of the WFIKKN gene in adult and fetal tissues and organs., [RefSeq, PubMed]; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)., [UniProtKB]; This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]., [RefSeq]; Three-dimensional structure of a Kunitz domain with a tryptophan residue at the P02 site of the protease-recognition loop, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7LDW0;Q8NBQ1;Q96S20",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0048019 receptor antagonist activity;GO:0050431 transforming growth factor beta binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96NZ8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15209-1",
        "uniprot_id": [
            {
                "id": "ZBT22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15209",
                "type": "external"
            }
        ],
        "mass": 65602.0,
        "length": 634,
        "protein_name": "Zinc finger and BTB domain-containing protein 22",
        "gene_name": "ZBTB22",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 22",
        "refseq_ac": [
            {
                "id": "NP_001138810",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138810",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZBTB22; BING1; ZBTB22A; ZNF297",
        "gene_names_refseq": "BING1; ZBTB22A; ZBTB22; ZNF297A; ZNF297; fruitless; fru",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 22; Protein BING1; Zinc finger and BTB domain-containing protein 22A; Zinc finger protein 297",
        "protein_names_refseq": "zinc finger and BTB domain-containing protein 22A; zinc finger and BTB domain-containing protein 22; zinc finger protein 297",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9278)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;19851445;23186163;28218747;28832583;28904123;31154438;31844290;35580925;9545376",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0V007;Q5HYV4;Q5STL0;Q5STR7;Q8WV82",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "O15209-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NBB4-1",
        "uniprot_id": [
            {
                "id": "ZSCA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NBB4",
                "type": "external"
            }
        ],
        "mass": 45286.0,
        "length": 408,
        "protein_name": "Zinc finger and SCAN domain-containing protein 1",
        "gene_name": "ZSCAN1",
        "organism": "Human",
        "refseq_name": "zinc finger and SCAN domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_872378",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872378",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZSCAN1",
        "gene_names_refseq": "MZF-1; ZNF915; ZSCAN1",
        "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 1",
        "protein_names_refseq": "zinc finger and SCAN domain-containing protein 1; zinc finger with SCAN domain 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284312)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;29485866;33981976",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3B798;Q6WLH8;Q86WS8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NBB4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3LI77-1",
        "uniprot_id": [
            {
                "id": "KR134_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3LI77",
                "type": "external"
            }
        ],
        "mass": 17755.0,
        "length": 160,
        "protein_name": "Keratin-associated protein 13-4",
        "gene_name": "KRTAP13-4",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 13-4",
        "refseq_ac": [
            {
                "id": "NP_853631",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853631",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRTAP13-4; KAP13.4",
        "gene_names_refseq": "KAP13.4; KRTAP13-4",
        "protein_names_uniprotkb": "Keratin-associated protein 13-4",
        "protein_names_refseq": "keratin-associated protein 13-4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284827);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 10,
        "publication_id_list": "15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRL3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q3LI77-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYD6-1",
        "uniprot_id": [
            {
                "id": "RM01_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYD6",
                "type": "external"
            }
        ],
        "mass": 36909.0,
        "length": 325,
        "protein_name": "Large ribosomal subunit protein uL1m",
        "gene_name": "MRPL1",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL1m precursor",
        "refseq_ac": [
            {
                "id": "NP_064621",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064621",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MRPL1; BM-022",
        "gene_names_refseq": "BM022; L1MT; MRP-L1; MRPL1; uL1m",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL1m; 39S ribosomal protein L1, mitochondrial; L1mt; MRP-L1",
        "protein_names_refseq": "39S ribosomal protein L1, mitochondrial; large ribosomal subunit protein uL1m precursor; mitochondrial large ribosomal subunit protein uL1m",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:65008);  (R-HSA-5368286);  (R-HSA-5389840);  (R-HSA-5419276);  (R-HSA-9937383)",
        "pathway_count": 5,
        "publication_count": 62,
        "publication_id_list": "11237011;11279069;15358359;17803939;18429816;18782833;19524667;19716793;20186120;20877624;21907147;22172991;2250005;24715725;25233460;25278503;25576301;26463840;27029019;28063628;28228285;28446606;28510447;28892042;28904123;29242379;29485866;29557506;29605689;29632046;30315122;30379171;30524438;31092671;31154438;31217245;31530632;31844290;32157095;32161166;32350084;32387766;32488085;32897882;32938616;32983136;33141586;33243891;33298915;33878294;33968037;34171305;34357683;34509645;35051231;35251023;35580925;36010968;36302763;36596788;37141370;40914422",
        "class_list": "",
        "function": "MLRP1 could possibly serve as a candidate gene for alterations associated with asbestos exposure., [RefSeq, PubMed]; Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NG03;Q4W5B8;Q6IAG4;Q96BW3;Q9H793;Q9NRL5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0015934 large ribosomal subunit",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0032543 mitochondrial translation;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q9BYD6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P51124-1",
        "uniprot_id": [
            {
                "id": "GRAM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P51124",
                "type": "external"
            }
        ],
        "mass": 27545.0,
        "length": 257,
        "protein_name": "Granzyme M",
        "gene_name": "GZMM",
        "organism": "Human",
        "refseq_name": "granzyme M isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_005308",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005308",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GZMM; MET1",
        "gene_names_refseq": "GZMM; LMET1; MET1",
        "protein_names_uniprotkb": "Granzyme M; 3.4.21.-; Hu-Met-1; Met-1 serine protease; Met-ase; Natural killer cell granular protease",
        "protein_names_refseq": "HU-Met-1; Met-1 serine protease; granzyme M isoform 1 preproprotein; lymphocyte met-ase 1; natural killer cell granular protease",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3004);  (R-HSA-173736)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "11237011;12506019;12927779;15028722;15494398;16818775;18523284;19542453;20406824;26811146;268620;279011;28904123;3052276;33953729;3421908;34357683;40914422;6707020;6912277;7713495;809512;8245461;82604;950465;978134",
        "class_list": "",
        "function": "Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells., [UniProtKB, PubMed, PubMed, PubMed]; Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage. Publication Status: Online-Only, [RefSeq, PubMed]; GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity., [RefSeq, PubMed]; Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis., [RefSeq, PubMed]; Granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells, [RefSeq, PubMed]; Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death., [RefSeq, PubMed]; Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]; Proteinase inhibitor 9 was effectively hydrolyzed and inactivated by human granzyme M, raising the possibility that this orphan granzyme bypasses proteinase inhibitor 9 inhibition of granzyme B, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "3.4.21.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.47",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "P51124-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100010010000.011.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P51810-1",
        "uniprot_id": [
            {
                "id": "GP143_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P51810",
                "type": "external"
            }
        ],
        "mass": 43878.0,
        "length": 404,
        "protein_name": "G protein-coupled receptor 143",
        "gene_name": "GPR143",
        "organism": "Human",
        "refseq_name": "G-protein coupled receptor 143 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000264",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000264",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPR143; OA1",
        "gene_names_refseq": "GPR143; NYS6; OA1",
        "protein_names_uniprotkb": "G protein-coupled receptor 143; Ocular albinism type 1 protein",
        "protein_names_refseq": "G-protein coupled receptor 143 isoform 1; ocular albinism 1; ocular albinism type 1 protein",
        "tax_id": 9606,
        "disease": "ocular albinism 1 (Disease Ontology:DOID:0050633); congenital nystagmus 6 (Disease Ontology:DOID:0111795)",
        "pathway": " (hsa:4935);  (R-HSA-375280);  (R-HSA-416476);  (R-HSA-9824585)",
        "pathway_count": 4,
        "publication_count": 94,
        "publication_id_list": "10094567;10191087;10471510;10567430;10587587;10727532;10861009;11015615;11115845;11214907;11237011;11459929;11532965;11742120;11753430;11793467;11856727;11964381;12062444;12120503;12643545;1321344;1537333;1537334;15543135;15695812;15729346;15951850;16182515;16268778;16303920;16339447;16524428;16621890;16646960;16754659;16923326;17081065;17182843;17218486;17516023;17822861;17952075;17960122;18434541;18483556;18515384;18577758;18697795;18812475;18828673;18936096;18978956;1905813;19389701;19717472;24267888;25645385;26694611;27600516;27869121;2841328;29557506;29632711;30515787;3086311;31154438;31844290;31848261;32157095;32488085;32582212;33100333;33392160;33592498;33912179;33968037;35580127;35580925;36800996;37394637;38222445;7647783;7813420;7937899;8306979;8634705;8664309;8921401;9305846;9529334;9758418;9770463;9887374",
        "class_list": "",
        "function": "GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis., [RefSeq, PubMed]; GPR143 mutations in an X-linked infantile nystagmus syndrome cohort in Southeast China. Publication Status: Online-Only, [RefSeq, PubMed]; L-DOPA Receptor GPR143 Functionally Couples with Adrenergic alpha1B Receptor at the Second Transmembrane Interface., [RefSeq, PubMed]; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Review: mutational analysis in ocular albinism type 1 Review article, [RefSeq, PubMed]; This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NTI7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0035643 L-DOPA receptor activity;GO:0035240 dopamine binding;GO:0072544 L-DOPA binding;GO:0072545 L-tyrosine binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0006726 eye pigment biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "P51810-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1L429-1",
        "uniprot_id": [
            {
                "id": "GG12C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A1L429",
                "type": "external"
            }
        ],
        "mass": 12925.0,
        "length": 117,
        "protein_name": "G antigen 12B/C/D/E",
        "gene_name": "GAGE12B; GAGE12C; GAGE12D; GAGE12E",
        "organism": "Human",
        "refseq_name": "G antigen 12B/C/D/E",
        "refseq_ac": [
            {
                "id": "NP_001091878",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091878",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GAGE12B; GAGE12C; GAGE12D; GAGE12E",
        "gene_names_refseq": "GAGE-12B; GAGE12C",
        "protein_names_uniprotkb": "G antigen 12B/C/D/E; GAGE-12B; GAGE-12C; GAGE-12D; GAGE-12E",
        "protein_names_refseq": "G antigen 12B/C/D/E; GAGE-12C; g antigen 12C/D/E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100132399);  (hsa:729422);  (hsa:729428);  (hsa:729431)",
        "pathway_count": 4,
        "publication_count": 2,
        "publication_id_list": "11237011;18179644",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NHF1;B7ZL74",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A1L429-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14756-1",
        "uniprot_id": [
            {
                "id": "H17B6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14756",
                "type": "external"
            }
        ],
        "mass": 35966.0,
        "length": 317,
        "protein_name": "17-beta-hydroxysteroid dehydrogenase type 6",
        "gene_name": "HSD17B6",
        "organism": "Human",
        "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 6 precursor",
        "refseq_ac": [
            {
                "id": "NP_003716",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003716",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSD17B6; RODH; SDR9C6",
        "gene_names_refseq": "HSD17B6; HSE; RODH; SDR9C6",
        "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 6; 1.1.1.105; 1.1.1.209; 1.1.1.239; 1.1.1.53; 1.1.1.62; 17-beta-HSD 6; 17-beta-HSD6; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; Oxidative 3-alpha hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 6",
        "protein_names_refseq": "17-beta-HSD 6; 17-beta-hydroxysteroid dehydrogenase type 6 precursor; 17-beta-hydroxysteroid dehydrogenase type 6; 3(alpha->beta)-hydroxysteroid epimerasel; 3(alpha->beta)-hydroxysteroid epimerase; 3-alpha->beta-HSE; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; hydroxysteroid (17-beta) dehydrogenase 6 homolog; oxidative 3-alpha-hydroxysteroid-dehydrogenase; oxidoreductase; retinol dehydrogenase; short chain dehydrogenase/reductase family 9C member 6",
        "tax_id": 9606,
        "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)",
        "pathway": " (hsa:8630);  (R-HSA-2453902)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "10075733;10617778;10753906;10896656;11123914;11237011;11274389;11360992;11513953;12036956;12177057;12407145;15314061;15471866;15865448;17255476;19049981;1925597;19309693;20192770;21493626;21774515;22665496;2303470;23481700;24244276;24715725;25422294;2542268;26992070;28218747;28228285;28834231;28904123;29557506;29769354;30315122;30410026;31154438;3170584;31844290;32732174;33592498;33717175;33912179;34171305;34185709;35051231;35580925;36284347;37217939;37330135;5315589;6288450;6342691;6512705;6589631;6679757;7929238;8105993;8884265;9188497;9490294;9541407;9703434;9920938",
        "class_list": "",
        "function": "HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation., [RefSeq, PubMed]; Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46,XY with hypospadias., [RefSeq, PubMed]; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids., [UniProtKB, PubMed, PubMed, PubMed]; No significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls., [RefSeq, PubMed]; The CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43275",
        "ec_number_list": [
            {
                "id": "1.1.1.105",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105",
                "type": "external"
            },
            {
                "id": "1.1.1.300",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300",
                "type": "external"
            },
            {
                "id": "1.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-",
                "type": "external"
            },
            {
                "id": "1.1.1.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64",
                "type": "external"
            },
            {
                "id": "1.1.1.54",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54",
                "type": "external"
            },
            {
                "id": "1.1.1.216",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.216",
                "type": "external"
            },
            {
                "id": "1.1.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62",
                "type": "external"
            },
            {
                "id": "1.1.1.239",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239",
                "type": "external"
            },
            {
                "id": "1.1.1.209",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209",
                "type": "external"
            },
            {
                "id": "1.1.1.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53",
                "type": "external"
            },
            {
                "id": "1.1.1.315",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315",
                "type": "external"
            },
            {
                "id": "1.1.1.270",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270",
                "type": "external"
            },
            {
                "id": "1.1.1.145",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145",
                "type": "external"
            },
            {
                "id": "5.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.210",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210",
                "type": "external"
            },
            {
                "id": "1.1.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51",
                "type": "external"
            },
            {
                "id": "1.1.1.225",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.225",
                "type": "external"
            },
            {
                "id": "1.1.1.357",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357",
                "type": "external"
            },
            {
                "id": "1.1.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1",
                "type": "external"
            },
            {
                "id": "1.1.1.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66",
                "type": "external"
            },
            {
                "id": "1.1.1.188",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188",
                "type": "external"
            },
            {
                "id": "1.1.1.112",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.112",
                "type": "external"
            },
            {
                "id": "1.3.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.20",
                "type": "external"
            },
            {
                "id": "1.1.1.149",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.149",
                "type": "external"
            },
            {
                "id": "1.1.1.330",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330",
                "type": "external"
            },
            {
                "id": "1.1.1.n12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12",
                "type": "external"
            },
            {
                "id": "1.1.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35",
                "type": "external"
            },
            {
                "id": "1.1.1.178",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178",
                "type": "external"
            },
            {
                "id": "1.1.1.159",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0003824 catalytic activity;GO:0016491 oxidoreductase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031901 early endosome membrane",
        "go_biological_process": "GO:0006710 androgen catabolic process;GO:0042572 retinol metabolic process;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process;GO:0008202 steroid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "O14756-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZC3-1",
        "uniprot_id": [
            {
                "id": "GDE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZC3",
                "type": "external"
            }
        ],
        "mass": 37718.0,
        "length": 331,
        "protein_name": "Glycerophosphodiester phosphodiesterase 1",
        "gene_name": "GDE1",
        "organism": "Human",
        "refseq_name": "glycerophosphodiester phosphodiesterase 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_057725",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057725",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GDE1; MIR16",
        "gene_names_refseq": "363E6.2; GDE1; MIR16",
        "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 1; 3.1.4.-; 3.1.4.44; Glycerophosphoinositol glycerophosphodiesterase GDE1; Lysophospholipase D GDE1; Membrane-interacting protein of RGS16; RGS16-interacting membrane protein",
        "protein_names_refseq": "RGS16-interacting membrane protein; glycerophosphodiester phosphodiesterase 1 isoform 1; glycerophosphoinositol glycerophosphodiesterase GDE1; lysophospholipase D GDE1; membrane interacting protein of RGS16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51573);  (R-HSA-6814848)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10.1101/2023.09.13.557529;10760272;11237011;12514188;12576545;15044461;15788404;16472945;16799181;17015841;18086666;18667693;23481700;24190977;25528375;25892735;26154972;26811146;26992070;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29769354;30429286;30779550;31844290;32077747;32157095;32350084;32357974;32387766;32488085;32862612;32938616;33141586;33298915;33537174;33592498;33912179;33936100;33968037;33981976;34088304;34185709;34357683;34405274;34509645;34561969;34932366;35051231;35251023;35580925;36284347;37074911;37938771;38665916",
        "class_list": "",
        "function": "Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis., [RefSeq, PubMed]; Regulation by by stimulation of G protein-coupled receptors, [RefSeq, PubMed]; Solanine inhibits proliferation and promotes apoptosis of the human leukemia cells by targeting the miR-16/Bcl-2 axis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43334;Q6PKF7;Q7KYR4",
        "ec_number_list": [
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.1.4.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.44",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane",
        "go_biological_process": "GO:0006580 ethanolamine metabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0006629 lipid metabolic process;GO:0046475 glycerophospholipid catabolic process;GO:0006644 phospholipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9NZC3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2TAP0-1",
        "uniprot_id": [
            {
                "id": "GOG7B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2TAP0",
                "type": "external"
            }
        ],
        "mass": 18335.0,
        "length": 167,
        "protein_name": "Golgin subfamily A member 7B",
        "gene_name": "GOLGA7B",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 7B",
        "refseq_ac": [
            {
                "id": "NP_001010917",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010917",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GOLGA7B; C10orf132; C10orf133",
        "gene_names_refseq": "C10orf132; C10orf133; GOLGA7B; bA451M19.3; bA459F3.4",
        "protein_names_uniprotkb": "Golgin subfamily A member 7B",
        "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 7B; golgin subfamily A member 7B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:401647)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "17074475;29242379;31402609;31844290;32157095;35051231;35416335",
        "class_list": "",
        "function": "Golgin A7 family member B (GOLGA7B) is a plausible novel gene associating high glycaemic index diet with acne vulgaris., [RefSeq, PubMed]; Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5 (PubMed:31402609). May be involved in protein transport from Golgi to cell surface., [UniProtKB, PubMed]; This work uncovers a novel mechanism of DHHC5 regulation by Golga7b and demonstrates a role for the DHHC5/Golga7b complex in the regulation of cell adhesion., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T4F5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0002178 palmitoyltransferase complex",
        "go_biological_process": "GO:0006612 protein targeting to membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q2TAP0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NMD2-1",
        "uniprot_id": [
            {
                "id": "GOG8J_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NMD2",
                "type": "external"
            }
        ],
        "mass": 71775.0,
        "length": 632,
        "protein_name": "Golgin subfamily A member 8J",
        "gene_name": "GOLGA8J",
        "organism": "Human",
        "refseq_name": "golgin subfamily A member 8J",
        "refseq_ac": [
            {
                "id": "NP_001269401",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269401",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GOLGA8J",
        "gene_names_refseq": "GOLGA8J",
        "protein_names_uniprotkb": "Golgin subfamily A member 8J",
        "protein_names_refseq": "Golgin subfamily A member 8-like protein 3; golgin subfamily A member 8J",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653073)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "10.1101/2023.09.13.557529;28832583;29242379",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H3BRU0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network;GO:0000137 Golgi cis cisterna",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A6NMD2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14522-3",
        "uniprot_id": [
            {
                "id": "PTPRT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14522",
                "type": "external"
            }
        ],
        "mass": 162134.0,
        "length": 1441,
        "protein_name": "Receptor-type tyrosine-protein phosphatase T",
        "gene_name": "PTPRT",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase T isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_008981",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008981",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRT; KIAA0283",
        "gene_names_refseq": "PTPRT; R-PTP-T; RPTP-rho; RPTPrho",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase T; 3.1.3.48; R-PTP-T; RPTP-rho; Receptor-type tyrosine-protein phosphatase rho",
        "protein_names_refseq": "receptor protein tyrosine phosphatase; receptor-type tyrosine-protein phosphatase T isoform 2 precursor; receptor-type tyrosine-protein phosphatase T; receptor-type tyrosine-protein phosphatase rho",
        "tax_id": 9606,
        "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:11122)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11423001;15155950;18987736;19167335;24123876;24715725;25576301;25645385;31844290;32157095;32387766;33912179;34087483;34414233;35051231;35789644;37054626;38216925;9179496;9602027",
        "class_list": "",
        "function": "Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in both signal transduction and cellular adhesion in the CNS., [UniProtKB]; Novel genetic variants linked to prelabor rupture of membranes among Chinese pregnant women., [RefSeq, PubMed]; PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 11,
        "predicted_n_glycosites": 10,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 169,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8E4R6;O43655;O75664;Q5W0X9;Q5W0Y1;Q9BR24;Q9BR28;Q9H0Y8;Q9NTL1;Q9NU72;Q9UBD2;Q9UJL7",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0042803 protein homodimerization activity;GO:0051393 alpha-actinin binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0031175 neuron projection development;GO:0030336 negative regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "O14522-3",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P33778-1",
        "uniprot_id": [
            {
                "id": "H2B1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P33778",
                "type": "external"
            }
        ],
        "mass": 13950.0,
        "length": 126,
        "protein_name": "Histone H2B type 1-B",
        "gene_name": "H2BC3",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-B",
        "refseq_ac": [
            {
                "id": "NP_066406",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066406",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC3; H2BFF; HIST1H2BB",
        "gene_names_refseq": "H2B.1; H2B/f; H2BC3; H2BFF; HIST1H2BB",
        "protein_names_uniprotkb": "Histone H2B type 1-B; H2B-clustered histone 3; H2B/f; Histone H2B.1; Histone H2B.f",
        "protein_names_refseq": "H2B histone family, member F; histone 1, H2bb; histone H2B type 1-B; histone H2B.1; histone H2B.f; histone cluster 1 H2B family member b; histone cluster 1, H2bb",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3018);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 59,
        "publication_count": 1249,
        "publication_id_list": "10029069;10037601;10074426;10080941;10097139;10199952;10204490;10233885;10319874;10323868;10330177;10330422;10347217;10391242;10411933;10425206;10430616;10432220;10438626;10444327;10444591;10449787;10471499;10485845;10500157;10548110;10550055;10551868;10558993;10562279;10562567;10572166;10583407;10617663;10655587;1066663;10669743;10706276;10722742;10724175;10728666;10734115;10748112;10757784;10766245;10769018;10772813;10775268;10777502;10786633;10802669;10821277;10828826;10831834;10835357;10859164;10866324;10871633;10873660;10882139;10882850;10904264;10921920;10922406;10926844;10928988;10930409;10956649;10959836;10970879;10973490;10978333;10982817;11010967;11025670;11027271;11034064;11050151;11056019;11080158;11080452;11103799;11114305;11114888;11136970;11136974;11139606;11165043;11204562;11242053;11242107;11274398;11278841;11292842;11301010;11340163;11340171;11345900;11356022;11369759;11376695;11390408;11390642;11401442;11410592;11452016;11454856;11467836;11493912;11507205;11509652;11532957;11564866;11566882;11571274;11573085;11581164;11590439;11604075;11673449;11682626;11684017;11702069;11709551;11713476;11739383;11740563;11741541;11742974;11744694;11747608;11830581;11847229;11867521;118839;11893489;11904416;11909966;11912130;11923872;11927591;11934263;11934988;11955432;11955446;11959841;11973335;11986212;11988739;12023295;12032298;12077346;12086618;12097317;12134156;12140329;12152085;12163411;12183469;12186630;12189133;12193592;12208845;12231622;12242300;12351676;12364621;12393752;12408966;12419226;12421820;12435631;12447390;12454989;12456671;12481029;12483298;12485996;12498683;12504854;12509254;12514133;12545175;12556884;12576332;12578958;12607003;12607005;12612073;12646563;12682017;12697768;12700765;12702500;1270801;12718543;12724404;12757711;12773400;12791985;12792649;12808055;12829629;12832467;12832489;12857923;12869508;12869583;12890688;12897153;12909626;12917689;12917691;12944405;12947387;12953102;12959972;1310260;13130130;13130464;14506261;14507994;14517214;14519844;14532106;14532133;14536086;14560035;14561766;14567678;14576433;14610093;14631847;14661020;14675539;14679213;14691562;14695187;14762106;14969726;14991602;15001666;15053880;15060161;15064394;15064416;15084397;15099518;15105426;15118850;15121853;15125634;15164066;15177042;15189136;15190204;15201865;15215855;15215856;15235794;15276198;15279782;15282324;15287722;15294866;15304223;15313887;15341901;15343269;15345050;15369670;15369671;15451442;15456747;15458641;15468306;15469825;15472075;15510216;15514030;15516265;15542832;15558034;15563468;15574327;15643423;15643425;15647753;15655109;15678106;15684396;15701600;15707391;15723659;15750587;15768032;15774718;15790808;15829968;15861382;15866172;15867264;15882967;15916963;15960975;15962837;15986123;16005293;16009131;16046058;16061182;16079151;16079795;16087863;16093244;16095617;16113099;16123081;16140760;16141325;16148040;16150728;16153896;16166375;16169192;16174740;16186106;16186825;16214042;16221681;16262255;16263726;16283522;16292313;16307923;1630819;16322221;16327781;16337592;16357870;16360315;16372014;16373483;16377563;16380219;16387653;16415179;16427009;16428440;16431907;16436515;16439204;16439205;16510874;16514417;16530042;16549775;16549788;16567619;16600297;16603238;16603771;16612405;16622420;16626623;16628190;16630820;16651405;16707490;16713563;16751774;16756492;16762929;16799559;16826196;16829525;16858402;16868077;16874298;16878130;16885023;16901786;16914548;16936726;16949368;16954381;16964248;16980581;17013392;17027977;17052462;17063141;17085592;17108083;17130289;17130829;17143291;17185360;17199038;17210787;17211407;17254968;17255097;17277772;17290220;17290226;17320160;17320161;17320163;17332741;17339379;17344414;17344417;17350655;17355984;17363312;17395714;17425515;17425782;17428788;17428831;17433364;17443180;17458864;17463000;17470781;17495528;17510434;17525332;17525340;17540598;17540599;17541404;17553757;17554337;17562868;1756725;17575048;17603073;17637753;17646674;17660710;17666587;17673620;17680271;17685488;17687327;17690249;17694070;17713478;17716973;17717186;17726030;17761849;17761950;17765224;17823410;17825402;17848578;17851529;17873522;17875933;17923702;17928296;17965729;17977839;17980597;17981138;17981954;18001824;18001825;18003914;18006705;18042460;18046455;18065497;18066052;18070888;18077395;18082607;18160704;18171670;18172164;18187655;18203656;18211953;18219272;18223688;18256232;18256600;18267069;18280240;18302924;18316480;18316726;1831692;18322535;18346456;18347063;18358809;18359941;18365017;18367646;1837051;18378692;18381289;18397950;18404694;18411265;18438399;18443292;18449172;18467330;18476782;18484335;18485871;1849145;18498752;18533032;18535008;18535146;18555777;18555778;18571423;18623064;18632802;18636086;18644861;18656484;18701449;18718915;18719106;18762174;18772889;18776924;18781158;18793328;18805091;18805503;18842624;18852463;18923075;18945682;18971343;18974356;18978028;19001364;19001859;19011241;19015242;19020303;19026781;19043829;19088198;19092802;19098913;19114653;19115252;19117993;19135894;19146767;19148484;19150886;19167051;1916825;19172745;19176521;19187765;19188362;19203578;19203579;19208625;19232136;19234442;1924375;19261749;19274700;19295514;19321454;19351884;19357644;19363159;19383337;19383768;19383769;19398495;19398555;19398759;19410543;19410544;19410545;19419957;19424180;19451217;19451218;19460168;19462008;19487454;19493659;19505854;19509293;19528227;19571010;19571879;19608861;19640981;19658395;19682613;19714243;19718048;19723507;19723635;19747919;1975088;19773441;19782031;19782034;19783983;19805069;19828817;19834512;19838211;19838300;19854132;19874889;19910467;20016603;20018852;20023648;20044539;20044541;20062530;20075857;20080577;20080834;20085832;20090754;20096447;20123894;20154705;20211137;20219941;20220130;20228808;20233725;2028256;20339092;20351093;20351172;20351173;20368735;20418909;20442293;20442780;20452968;20453063;20495621;20498280;20501646;20523938;20551165;20551166;20566683;20570965;20622854;20630873;20634189;20651253;20661648;20676056;20682797;20801121;20805998;20807650;20818382;20838592;20841325;20871592;20876458;20887958;20937877;20966048;20974918;21052091;21106759;21129147;21151129;21163962;21170310;2118650;21203937;21212262;21239494;21240188;21252065;21263215;21280156;21282113;21293379;21325134;21329877;21335604;21362556;21378119;21396873;21402699;21427083;21445275;21471526;21489993;21490301;21498573;21515671;21544310;21551231;21554508;21555516;21559432;21571218;21571647;21573489;21587264;21589992;21596315;21602795;21646345;21654818;21659512;21659603;21680713;21690215;21706000;21722948;21725049;21726809;21726816;21768289;21777809;21777816;21808299;21808300;2181374;2183031;21835891;21849505;21875955;21878914;21899694;21911480;21911577;21925322;21934649;21940756;2195544;21962518;21979375;21979949;21986495;21993314;22012064;22020331;22021381;22021426;22022377;22024395;22029577;22046413;22056668;22064703;22064859;22065755;22085928;22110129;22128162;22131221;22158034;22174689;22178396;22179609;22186018;22190459;22216260;22231403;22234877;22265404;22323599;22325352;22336108;22348533;22362753;22371011;22373579;22389435;22398447;22420752;22445173;22466170;22474248;22492511;22508508;22529269;22544926;22545144;22569126;22569366;22569481;22589545;22617422;22634325;22635276;22658674;22661229;22661230;22683641;22684280;22704330;22705304;22722852;22751019;22777353;22792074;22848106;22879880;22897851;22908299;22922743;22961379;22962365;22977173;22980979;22982193;23001182;23022729;23145106;23150874;23159851;23161542;23172872;23187890;23192763;23219899;23239876;23285124;2330041;23303788;23306437;23326524;23333306;23345434;23361464;23395819;23403292;23408615;2342578;23431328;23435229;23466526;23468639;23486064;23498719;23505375;23534758;23555303;23630040;23667505;23679895;23723241;23727112;23752590;23755964;23795651;23813966;23824326;23825189;23846687;23882114;23897426;23906331;2392154;24003239;2405250;24056413;24074865;24086155;2409350;24167369;24174538;24236237;24252660;24260525;24307175;24312487;24368767;24371278;24379003;24385926;24388755;24493797;24531329;24554700;24584857;24586203;24596094;24662292;24667604;24681537;24706756;24735615;24807418;24833601;24854081;24885040;24893886;24896179;24901984;24920672;24952918;24973012;24979766;24998469;25030448;25043025;25101834;25113031;25122754;25135475;25150861;25170678;25197364;25240135;2524830;25274305;25296600;25305019;25313066;25365482;25394790;25433557;25512557;25523424;25542856;25558984;25578727;25593184;25593309;25633194;25659039;25663755;25674852;25689043;2570724;25728767;25728771;25753662;25784553;25784653;25818648;25841101;25913784;25916849;25936802;26010396;26018760;26022416;26055325;26056233;26086376;26092250;26095805;26101246;26139588;26153859;26154972;26204489;26210183;26212009;26216882;26344566;26350214;26417681;26462610;26479350;26572645;26668317;26686862;26711259;26807092;26813693;26977885;26992070;27062924;27105113;27105115;27108190;27137657;2721961;27354518;27501258;27530147;27569044;27597759;27633282;27661449;27692985;27732843;27732854;27798111;27806305;27886276;279930;28273063;28404884;28415052;28533432;28539435;28581500;28854357;28904123;28977666;2900981;29042441;29101237;2919170;29211708;29351928;29431622;29557506;29608566;29643390;29728366;29729076;29795351;29902443;30045876;30122475;30134174;30154464;30228260;30327463;3035556;30360396;30385408;3045126;30484775;3053705;30599162;30761409;3080684;30898548;30923826;3094007;30980593;30993897;31086175;31289231;3142462;31427381;31542297;31611695;31645732;31746185;32157095;32183950;32188940;32581010;32808929;3281094;32860047;32976585;33009411;33091337;33177556;33264408;33283408;33298899;33329381;33608512;33801762;34357683;34545082;3484703;34874266;34961760;3498214;35008676;35138000;35215846;35292107;35314832;35851744;36008597;36172813;3675579;3677090;37217939;38359823;3886654;4054110;500690;6261960;6604055;7391081;7479006;7488013;7501971;7513682;7535770;7559524;7578059;7588633;7597036;7816143;7831296;7859739;7862113;7906964;7908827;7935485;7937828;7969165;8001816;8016081;8033412;8078588;8097946;8110764;8114934;8159701;8195246;8195709;8197458;8218289;8234276;8242751;8242752;8259215;8284199;8319905;8384717;8407958;8413215;8413306;8419924;8422676;8464497;8475094;8490014;8521497;8521498;8617720;8622669;8622688;8625414;8626550;8662714;8674428;8688489;8695841;8710908;874082;8741839;8756721;8757136;8759021;8769649;8774846;8794855;8846784;8846917;8870004;8876171;8878478;8884985;8929543;8939459;8944023;8955148;8974401;8985174;8991089;9006323;9008167;9016654;9030721;9054935;9065481;9118222;9150135;9162092;9168116;9171241;9177240;9187114;9195981;9201922;9207108;9214382;9218805;9223305;9223306;9259561;9272954;9285814;9311981;9321410;9338790;9388265;9427644;9427705;9430628;9430729;9450758;9482740;9488439;9488723;9490669;9512513;9512523;9529249;9558366;9564042;9611253;9628874;9651585;9671459;9693032;9705271;9705289;9731700;9733514;9733515;9744270;9751710;9768359;9781043;9790531;9790534;9804427;9811839;9819412;9824166;9826654;9826763;9843217;9843967;9862427;9880483;9885572;9890904",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. Publication Status: Online-Only, [RefSeq, PubMed]; HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]; Monoubiquitination of histone H2B blocks eviction of histone variant H2A.Z from inducible enhancers., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4KN36",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 125.5,
        "record_id": "P33778-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P58876-1",
        "uniprot_id": [
            {
                "id": "H2B1D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P58876",
                "type": "external"
            }
        ],
        "mass": 13936.0,
        "length": 126,
        "protein_name": "Histone H2B type 1-D",
        "gene_name": "H2BC5",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-D",
        "refseq_ac": [
            {
                "id": "NP_066407",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066407",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC5; H2BFB; HIRIP2; HIST1H2BD",
        "gene_names_refseq": "H2B.1B; H2B/a; H2B/b; H2B/g; H2B/h; H2B/k; H2B/l; H2BC5; H2BFA; H2BFB; H2BFG; H2BFH; H2BFK; H2BFL; HIRIP2; HIST1H2BC; HIST1H2BD; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI; dJ221C16.6",
        "protein_names_uniprotkb": "Histone H2B type 1-D; H2B-clustered histone 5; H2B/b; HIRA-interacting protein 2; Histone H2B.1 B; Histone H2B.b",
        "protein_names_refseq": "H2B histone family, member B; HIRA-interacting protein 2; Histone H2B type 1-C/E/F/G/I; Histone H2B.1 A; Histone H2B.a; Histone H2B.g; Histone H2B.h; Histone H2B.k; Histone H2B.l; histone 1, H2bd; histone H2B type 1-D; histone H2B.1 B; histone H2B.b; histone cluster 1 H2B family member d; histone cluster 1, H2bd",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3017);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 59,
        "publication_count": 1266,
        "publication_id_list": "10029069;10037601;10074426;10080941;10097139;10199952;10204490;10233885;10319874;10323868;10330177;10330422;10347217;10391242;10411933;10425206;10432220;10438626;10444327;10444591;10449787;10471499;10485845;10500157;10548110;10550055;10551868;10558993;10562279;10562567;10572166;10583407;10617663;10655587;1066663;10669743;10706276;10722742;10724175;10728666;10734115;10748112;10757784;10766245;10769018;10772813;10775268;10777502;10786633;10802669;10821277;10828826;10831834;10835357;10859164;10866324;10871633;10873660;10882139;10882850;10904264;10921920;10922406;10926844;10928988;10930409;10956649;10959836;10970879;10973490;10978333;10982817;11010967;11025670;11027271;11034064;11050151;11056019;11080158;11080452;11103799;11114305;11114888;11136970;11136974;11139606;11165043;11204562;11242053;11242107;11274398;11278841;11292842;11301010;11340163;11340171;11345900;11356022;11369759;11376695;11390408;11390642;11401442;11410592;11452016;11454856;11467836;11493912;11507205;11509652;11532957;11564866;11566882;11571274;11573085;11581164;11590439;11604075;11673449;11682626;11684017;11702069;11713476;11739383;11740563;11741541;11742974;11744694;11747608;11830581;11847229;11867521;118839;11893489;11904416;11909966;11912130;11923872;11927591;11934263;11934988;11955432;11955446;11959841;11973335;11986212;11988739;12023295;12032298;12077346;12086618;12097317;12134156;12140329;12152085;12163411;12183469;12186630;12189133;12193592;12208845;12231622;12242300;12351676;12364621;12393752;12408966;12419226;12421820;12435631;12447390;12454989;12456671;12481029;12483298;12485996;12498683;12504854;12509254;12514133;12545175;12556884;12576332;12578958;12607003;12607005;12612073;12646563;12682017;12697768;12700765;12702500;1270801;12718543;12724404;12757711;12773400;12791985;12792649;12808055;12829629;12832467;12832489;12857923;12869508;12869583;12890688;12897153;12909626;12917689;12917691;12944405;12947387;12953102;12959972;1310260;13130130;13130464;14506261;14507994;14517214;14519844;14532106;14532133;14536086;14560035;14561766;14567678;14576433;14610093;14631847;14661020;14675539;14679213;14691562;14695187;14762106;14969726;14991602;15001666;15053880;15060161;15064394;15064416;15084397;15099518;15105426;15121853;15125634;15164066;15177042;15189136;15190204;15201865;15215855;15215856;15235794;15276198;15279782;15282324;15287722;15294866;15304223;15313887;15341901;15343269;15345050;15369670;15369671;15451442;15456747;15458641;15468306;15469825;15472075;15510216;15514030;15516265;15542832;15558034;15563468;15574327;15643423;15643425;15647753;15655109;15678106;15684396;15701600;15707391;15723659;15750587;15768032;15774718;15790808;15829968;15861382;15866172;15867264;15882967;15916963;15960975;15962837;15986123;16005293;16009131;16046058;16061182;16079151;16079795;16087863;16093244;16095617;16113099;16123081;16140760;16141325;16148040;16150728;16153896;16166375;16169192;16174740;16186106;16186825;16214042;16221681;16262255;16263726;16283522;16292313;16307923;1630819;16319397;16322221;16327781;16337592;16357870;16360315;16372014;16373483;16377563;16380219;16387653;16415179;16427009;16428440;16431907;16436515;16439204;16439205;16457587;16510874;16514417;16530042;16549775;16549788;16567619;16600297;16603238;16603771;16612405;16622420;16626623;16627869;16628190;16630820;16651405;16707490;16713563;16751774;16756492;16762929;16799559;16826196;16829525;16858402;16868077;16874298;16878130;16885023;16901786;16914548;16936726;16949368;16954381;16964248;16980581;17013392;17027977;17052462;17063141;17085592;17108083;17130289;17130829;17143291;17185360;17199038;17210787;17211407;17254968;17255097;17277772;17290220;17290226;17320160;17320161;17320163;17332741;17339379;17344414;17344417;17350655;17355984;17363312;17395714;17425515;17425782;17428788;17428831;17433364;17443180;17458864;17463000;17470781;17495528;17510434;17525332;17525340;17540598;17540599;17541404;17553757;17554337;17562868;1756725;17575048;17603073;17637753;17646674;17660710;17666587;17673620;17680271;17685488;17687327;17690249;17694070;17713478;17716973;17717186;17726030;17761849;17761950;17765224;17823410;17825402;17848578;17851529;17873522;17875933;17923702;17928296;17965729;17977839;17980597;17981138;17981954;18001824;18001825;18003914;18006705;18042460;18046455;18065497;18066052;18070888;18077395;18082607;18160704;18171670;18172164;18187655;18203656;18211953;18219272;18223688;18256232;18256600;18267069;18280240;18302924;18316480;18316726;1831692;18322535;18346456;18347063;18358809;18359941;18365017;18367646;1837051;18378692;18381289;18397950;18404694;18411265;18438399;18443292;18449172;18467330;18476782;18484335;18485871;1849145;18498752;18533032;18535008;18535146;18555777;18555778;18571423;18623064;18632802;18636086;18644861;18656484;18701449;18718915;18719106;18762174;18772889;18776924;18781158;18793328;18805091;18805503;18842624;18852463;18923075;18945682;18971343;18974356;18978028;19001364;19001859;19011241;19015242;19020303;19026781;19043829;19088198;19092802;19098913;19114653;19115252;19117993;19135894;19146767;19148484;19150886;19167051;1916825;19172745;19176521;19187765;19188362;19203578;19203579;19208625;19232136;19234442;1924375;19261749;19274700;19295514;19321454;19351884;19357644;19363159;19383337;19383768;19383769;19398495;19398555;19398759;19410543;19410544;19410545;19419957;19424180;19451217;19451218;19460168;19462008;19487454;19493659;19505854;19509293;19528227;19571010;19571879;19608861;19640981;19658395;19682613;19714243;19718048;19723507;19723635;19747919;1975088;19773441;19782031;19782034;19783983;19805069;19828817;19834512;19838211;19838300;19854132;19874889;19910467;20016603;20018852;20023648;20044539;20044541;20062530;20075857;20080577;20080834;20085832;20090754;20096447;20123894;20154705;20211137;20219941;20220130;20228808;20233725;2028256;20339092;20351093;20351172;20351173;20368735;20418909;20442293;20442780;20452968;20453063;20495621;20498280;20501646;20523938;20551165;20551166;20566683;20570965;20622854;20630873;20634189;20651253;20661648;20676056;20682797;20707881;20801121;20805998;20807650;20818382;20838592;20841325;20871592;20876458;20887958;20937877;20966048;20974918;21052091;21106759;21129147;21151129;21163962;21170310;2118650;21203937;21224338;21239494;21240188;21252065;21263215;21280156;21282113;21293379;21325134;21329877;21335604;21362556;21378119;21396873;21402699;21427083;21445275;21471526;21489993;21490301;21498573;21515671;21544310;21551231;21554508;21555516;21559432;21571218;21571647;21573489;21587264;21589992;21596315;21602795;21654818;21659512;21659603;21680713;21690215;21706000;21722948;21725049;21726809;21726816;21768289;21777809;21777816;21808299;21808300;2181374;2183031;21835891;21849505;21875955;21878914;21899694;21911480;21911577;21925322;21934649;21940756;2195544;21962518;21979375;21979949;21986495;21993314;22012064;22020331;22021381;22021426;22022377;22024395;22029577;22046413;22056668;22064703;22064859;22065755;22085928;22110129;22128162;22131221;22158034;22174689;22178396;22179609;22186018;22190459;22216260;22231403;22234877;22265404;22323599;22325352;22336108;22348533;22362753;22371011;22373579;22389435;22398447;22420752;22424782;22445173;22466170;22474248;22492511;22508508;22529269;22545144;22569126;22569366;22569481;22589545;22617422;22634325;22635276;22658674;22661229;22661230;22683641;22684280;22704330;22705304;22722852;22751019;22777353;22792074;22848106;22879880;22897851;22908299;22922743;22961379;22962365;22977173;22980979;22982193;23001182;23022729;23145106;23150874;23159851;23161542;23172872;23187890;23192763;23219899;23239876;23285124;2330041;23303788;23306437;23326524;23333306;23345434;23361464;23395819;23403292;23408615;2342578;23431328;23435229;23466526;23468639;23486064;23498719;23505375;23534758;23555303;23630040;23667505;23679895;23723241;23727112;23752590;23755964;23795651;23813966;23824326;23825189;23846687;23882114;23897426;23906331;2392154;24003239;2405250;24056413;24074865;24086155;2409350;24167369;24174538;24236237;24252660;24260525;24307175;24312487;24368767;24371278;24379003;24385926;24388755;24493797;24531329;24554700;24584857;24586203;24596094;24662292;24667604;24681537;24706756;24714562;24715725;24735615;24807418;24833601;24854081;24885040;24893886;24896179;24901984;24920672;24952918;24973012;24979766;24998469;25030448;25043025;25101834;25113031;25122754;25135475;25150861;25170678;25197364;25240135;2524830;25274305;25296600;25305019;25313066;25365482;25394790;25433557;25469497;25512557;25523424;25542856;25558984;25578727;25593184;25593309;25633194;25659039;25663755;25674852;25689043;2570724;25728767;25728771;25753662;25755297;25784553;25784653;25818648;25841101;25913784;25916849;25936802;26010396;26018760;26022416;26055325;26056233;26086376;26092250;26095805;26101246;26139588;26153859;26154972;26204489;26210183;26212009;26216882;26344566;26350214;26417681;26462610;26479350;26572645;26668317;26686862;26711259;26807092;26813693;26977885;27062924;27105113;27105115;27108190;27137657;2721961;27354518;27501258;27530147;27569044;27597759;27633282;27661449;27723750;27732843;27732854;27798111;27806305;27886276;279930;28273063;28404884;28415052;28533432;28539435;28581500;28854357;28977666;2900981;29042441;29101237;2919170;29211708;29431622;29557506;29608566;29728366;29729076;29795351;29902443;30045876;30122475;30134174;30154464;30228260;30327463;3035556;30360396;30379171;30385408;3045126;3053705;30599162;30761409;3080684;30898548;30923826;3094007;30980593;30981630;30993897;31086175;31289231;3142462;31427381;31542297;31611695;31645732;31717259;31746185;32183950;32188940;32350084;32502341;32808929;3281094;32860047;32976585;32983136;33009411;33141586;33177556;33264408;33283408;33298899;33298915;33329381;33592498;33608512;33717175;33801762;33912179;33933143;33936100;34019948;34087483;34105348;34171305;34357683;34545082;3484703;34874266;34961760;3498214;35008676;35138000;35154160;35215846;35251023;35292107;35314832;35851744;36008597;36172813;3675579;3677090;37217939;37938771;38359823;3886654;39302247;4054110;500690;6261960;6604055;7391081;7479006;7488013;7501971;7513682;7535770;7559524;7578059;7588633;7597036;7816143;7831296;7859739;7862113;7906964;7908827;7935485;7937828;7969165;8001816;8016081;8033412;8078588;8097946;8110764;8114934;8159701;8195246;8195709;8197458;8218289;8234276;8242751;8242752;8259215;8284199;8319905;8384717;8407958;8413215;8413306;8419924;8422676;8464497;8475094;8490014;8521497;8521498;8617720;8622669;8622688;8625414;8626550;8662714;8674428;8688489;8695841;8710908;874082;8741839;8756721;8757136;8759021;8769649;8774846;8794855;8846784;8846917;8870004;8876171;8878478;8884985;8929543;8939459;8944023;8955148;8974401;8991089;9006323;9008167;9016654;9030721;9054935;9065481;9118222;9150135;9162092;9168116;9171241;9177240;9187114;9195981;9201922;9207108;9214382;9218805;9223305;9223306;9259561;9272954;9285814;9311981;9321410;9338790;9388265;9427644;9427705;9430628;9430729;9450758;9482740;9488439;9488723;9490669;9512513;9512523;9529249;9558366;9564042;9611253;9628874;9651585;9671459;9693032;9705271;9705289;9710638;9731700;9733514;9733515;9744270;9751710;9768359;9781043;9790531;9790534;9804427;9811839;9819412;9824166;9826654;9826763;9843217;9843967;9862427;9880483;9885572;9890904",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Epigenetic landscape of testis specific histone H2B variant and its influence on sperm function. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]; We report cryo-EM structures of human Dot1L bound to (1) H2BK120Ub and (2) unmodified nucleosome substrates at 3.5 A and 4.9 A, respectively. Comparison of both structures, complemented with biochemical experiments, provides critical insights into the mechanism of Dot1L stimulation by H2BK120Ub., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 127.1,
        "record_id": "P58876-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96A08-1",
        "uniprot_id": [
            {
                "id": "H2B1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96A08",
                "type": "external"
            }
        ],
        "mass": 14167.0,
        "length": 127,
        "protein_name": "Histone H2B type 1-A",
        "gene_name": "H2BC1",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-A",
        "refseq_ac": [
            {
                "id": "NP_733759",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733759",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC1; HIST1H2BA; TSH2B",
        "gene_names_refseq": "H2BC1; H2BFU; HIST1H2BA; STBP; TH2B; TSH2B.1; TSH2B; bA317E16.3; hTSH2B",
        "protein_names_uniprotkb": "Histone H2B type 1-A; Histone H2B, testis; TSH2B.1; Testis-specific histone H2B; hTSH2B",
        "protein_names_refseq": "H2B histone family, member U, (testis-specific); histone 1, H2ba; histone H2B type 1-A; histone H2B, testis; histone cluster 1 H2B family member a; histone cluster 1, H2ba; testis-specific histone H2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255626);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 59,
        "publication_count": 1257,
        "publication_id_list": "10029069;10037601;10074426;10080941;10097139;10199952;10204490;10233885;10319874;10323868;10330177;10330422;10347217;10391242;10411933;10425206;10432220;10438626;10444327;10444591;10449787;10471499;10485845;10500157;10548110;10550055;10551868;10558993;10562279;10562567;10572166;10583407;10617663;10655587;1066663;10669743;10706276;10722742;10724175;10728666;10734115;10748112;10757784;10766245;10769018;10772813;10775268;10777502;10786633;10802669;10821277;10828826;10831834;10835357;10859164;10866324;10871633;10873660;10882139;10882850;10904264;10921920;10922406;10926844;10928988;10930409;10956649;10959836;10970879;10973490;10978333;10982817;11010967;11025670;11027271;11034064;11050151;11056019;11080158;11080452;11103799;11114305;11114888;11136970;11136974;11139606;11165043;11204562;11242053;11242107;11274398;11278841;11292842;11301010;11340163;11340171;11345900;11356022;11369759;11376695;11390408;11390642;11401442;11410592;11452016;11454856;11467836;11493912;11507205;11509652;11532957;11564866;11566882;11571274;11573085;11581164;11590439;11604075;11673449;11682626;11684017;11702069;11713476;11739383;11740563;11741541;11742974;11744694;11747608;11830581;11847229;11867521;118839;11893489;11904416;11909966;11912130;11923872;11927591;11934263;11934988;11955432;11955446;11959841;11973335;11986212;11988739;12023295;12032298;12077346;12086618;12097317;12134156;12140329;12152085;12163411;12183469;12186630;12189133;12193592;12208845;12213818;12231622;12242300;12351676;12364621;12393752;12408966;12419226;12421820;12435631;12447390;12454989;12456671;12481029;12483298;12485996;12498683;12504854;12509254;12514133;12545175;12556884;12576332;12578958;12607003;12607005;12612073;12646563;12682017;12697768;12700765;12702500;1270801;12718543;12724404;12773400;12791985;12792649;12808055;12829629;12832467;12832489;12857923;12869508;12869583;12890688;12897153;12909626;12917689;12917691;12944405;12947387;12953102;12959972;1310260;13130130;13130464;14506261;14507994;14517214;14519844;14532106;14532133;14536086;14560035;14561766;14567678;14576433;14610093;14631847;14661020;14675539;14679213;14691562;14695187;14762106;14969726;14991602;15001666;15053880;15060161;15064394;15064416;15084397;15099518;15105426;15121853;15125634;15164066;15177042;15189136;15190204;15201865;15215855;15215856;15235794;15276198;15279782;15282324;15287722;15294866;15304223;15313887;15341901;15343269;15345050;15369670;15369671;15451442;15456747;15458641;15468306;15469825;15472075;15510216;15514030;15516265;15542832;15558034;15563468;15574327;15643423;15643425;15647753;15655109;15678106;15684396;15701600;15707391;15723659;15750587;15768032;15774718;15790808;15829968;15861382;15866172;15867264;15882967;15916963;15960975;15962837;15986123;16005293;16009131;16046058;16061182;16079151;16079795;16087863;16093244;16095617;16113099;16123081;16140760;16141325;16148040;16150728;16153896;16166375;16169192;16174740;16186106;16186825;16214042;16221681;16262255;16263726;16283522;16292313;16307923;1630819;16322221;16327781;16337592;16357870;16360315;16372014;16373483;16377563;16380219;16387653;16415179;16427009;16428440;16431907;16436515;16439204;16439205;16510874;16514417;16530042;16549775;16549788;16567619;16600297;16603238;16603771;16612405;16622420;16626623;16628190;16630820;16651405;16707490;16713563;16751774;16756492;16762929;16799559;16826196;16829525;16858402;16868077;16874298;16878130;16885023;16901786;16914548;16936726;16949368;16954381;16964248;16980581;17013392;17027977;17052462;17063141;17085592;17108083;17130289;17130829;17143291;17185360;17199038;17210787;17211407;17254968;17255097;17277772;17290220;17290226;17320160;17320161;17320163;17332741;17339379;17344414;17344417;17350655;17355984;17363312;17395714;17425515;17425782;17428788;17428831;17433364;17443180;17458864;17463000;17470781;17495528;17510434;17525332;17525340;17540598;17540599;17541404;17553757;17554337;17562868;1756725;17575048;17603073;17637753;17646674;17660710;17666587;17673620;17680271;17685488;17687327;17690249;17694070;17713478;17716973;17717186;17726030;17761849;17761950;17765224;17823410;17825402;17848578;17851529;17873522;17875933;17923702;17928296;17965729;17977839;17980597;17981138;17981954;18001824;18001825;18003914;18006705;18042460;18046455;18065497;18066052;18070888;18077395;18082607;18160704;18171670;18172164;18187655;18203656;18211953;18219272;18223688;18256232;18256600;18267069;18280240;18302924;18316480;18316726;1831692;18322535;18346456;18347063;18358809;18359941;18365017;18367646;1837051;18378692;18381289;18397950;18404694;18411265;18438399;18443292;18449172;18467330;18476782;18484335;18485871;1849145;18498752;18533032;18535008;18535146;18555777;18555778;18571423;18623064;18632802;18636086;18644861;18656484;18701449;18718915;18719106;18762174;18772889;18776924;18781158;18793328;18805091;18805503;18842624;18852463;18923075;18945682;18971343;18974356;18978028;19001364;19001859;19011241;19015242;19020303;19026781;19043829;19088198;19092802;19098913;19114653;19115252;19117993;19135894;19146767;19148484;19150886;19167051;19172745;19176521;19187765;19188362;19203578;19203579;19208625;19232136;19234442;1924375;19261749;19274700;19295514;19321454;19351884;19357644;19363159;19383337;19383768;19383769;19398495;19398555;19398759;19410543;19410544;19410545;19419957;19424180;19451217;19451218;19460168;19462008;19487454;19493659;19505854;19509293;19528227;19571010;19571879;19640981;19658395;19682613;19714243;19718048;19723507;19723635;19747919;1975088;19773441;19782031;19782034;19783983;19805069;19828817;19834512;19838211;19838300;19854132;19874889;19910467;20016603;20018852;20023648;20044539;20044541;20062530;20075857;20080577;20080834;20085832;20090754;20096447;20123894;20154705;20211137;20219941;20220130;20228808;20233725;2028256;20339092;20351093;20351172;20351173;20368735;20418909;20442293;20442780;20452968;20453063;20495621;20498280;20501646;20523938;20551165;20551166;20566683;20570965;20622854;20630873;20634189;20651253;20661648;20676056;20682797;20801121;20805998;20807650;20818382;20838592;20841325;20871592;20876458;20887958;20937877;20966048;20974918;21052091;21106759;21129147;21151129;21163962;21170310;2118650;21203937;21239494;21240188;21249133;21252065;21263215;21280156;21282113;21293379;21325134;21329877;21335604;21362556;21378119;21396873;21402699;21427083;21445275;21471526;21489993;21490301;21498573;21515671;21544310;21551231;21554508;21555516;21559432;21571218;21571647;21573489;21587264;21589992;21596315;21602795;21654818;21659512;21659603;21680713;21690215;21706000;21722948;21725049;21726809;21726816;21768289;21777809;21777816;21808299;21808300;2181374;2183031;21835891;21849505;21875955;21878914;21896475;21899694;21911480;21911577;21925322;21934649;21940756;2195544;21962518;21979375;21979949;21986495;21993314;22012064;22020331;22021381;22021426;22022377;22024395;22029577;22046413;22056668;22064703;22064859;22065755;22085928;22110129;22128162;22131221;22158034;22174689;22178396;22179609;22186018;22190459;22216260;22231403;22234877;22265404;22323599;22325352;22336108;22348533;22362753;22371011;22373579;22398447;22420752;22445173;22466170;22474248;22492511;22508508;22529269;22545144;22569126;22569366;22569481;22589545;22617422;22634325;22635276;22658674;22661229;22661230;22683641;22684280;22704330;22705304;22722852;22751019;22777353;22792074;22848106;22879880;22897851;22908299;22922743;22961379;22962365;22977173;22980979;22982193;23001182;23022729;23145106;23150874;23159851;23161542;23172872;23187890;23192763;23219899;23239876;23285124;2330041;23303788;23306437;23326524;23333306;23345434;23361464;23395819;23403292;23408615;2342578;23431328;23435229;23466526;23468639;23486064;23498719;23505375;23534758;23555303;23630040;23667505;23679895;23723241;23727112;23752590;23755964;23783831;23795651;23813966;23824326;23825189;23846687;23882114;23897426;23906331;2392154;24003239;2405250;24056413;24074865;24086155;2409350;24167369;24174538;24236237;24252660;24260525;24307175;24312487;24368767;24371278;24379003;24385926;24388755;24493797;24531329;24554700;24584857;24586203;24596094;24662292;24667604;24706756;24735615;24807418;24833601;24854081;24885040;24893886;24896179;24901984;24920672;24952918;24973012;24979766;24998469;25030448;25043025;25101834;25113031;25122754;25135475;25150861;25170678;25197364;25240135;2524830;25274305;25296600;25305019;25313066;25365482;25394790;25433557;25505266;25512557;25523424;25542856;25558984;25578727;25593184;25593309;25633194;25645385;25659039;25663755;25674852;25689043;2570724;25728767;25728771;25753662;25784553;25784653;25818648;25841101;25913784;25916849;25936802;26010396;26018760;26022416;26055325;26056233;26086376;26092250;26095805;26101246;26139588;26153859;26154972;26204489;26210183;26212009;26216882;26344566;26350214;26417681;26462610;26479350;26572645;26668317;26686862;26711259;26759222;26807092;26811146;26813693;26977885;27062924;27108190;27137657;2721961;27354518;27452731;27501258;27569044;27597759;27600516;27633282;27661449;27716488;27732843;27732854;27798111;27806305;27886276;27920218;279930;28063628;28218747;28228285;28257841;28273063;28404884;28415052;28514659;28533432;28539435;28581500;28832583;28834231;28854357;28904123;28977666;2900981;29042441;29101237;2919170;29211708;29242379;29393594;29431622;29493099;29508533;29557506;29608566;29632046;29632711;29728366;29729076;29769354;29786170;29789417;29795351;29902443;30045876;30122475;30134174;30192525;30228260;30315122;30327463;3035556;30360396;30385408;30397120;30429286;3045126;30524438;3053705;30599162;30761409;3080684;30898548;30923826;3094007;30980593;30993897;31086175;31289231;3142462;31427381;31611695;31645732;31746185;32183950;32188940;32387766;32808929;3281094;32860047;32976585;33009411;33091337;33177556;33264408;33283408;33298899;33329381;33392160;33608512;33801762;33981976;3484703;3498214;35008676;35138000;35215846;35292107;35314832;35851744;36008597;36172813;3675579;3677090;37217939;38359823;3886654;4054110;500690;6261960;6604055;7391081;7479006;7488013;7501971;7513682;7535770;7559524;7578059;7588633;7597036;7816143;7831296;7859739;7862113;7906964;7908827;7935485;7937828;7969165;8001816;8016081;8033412;8078588;8097946;8110764;8114934;8159701;8195246;8195709;8197458;8218289;8234276;8242751;8242752;8259215;8284199;8319905;8384717;8407958;8413215;8413306;8419924;8422676;8464497;8475094;8490014;8521497;8521498;8617720;8622669;8622688;8625414;8626550;8662714;8674428;8688489;8695841;8710908;874082;8741839;8756721;8757136;8759021;8769649;8774846;8794855;8846784;8846917;8870004;8876171;8878478;8884985;8929543;8939459;8944023;8955148;8974401;8991089;9006323;9008167;9016654;9030721;9054935;9065481;9118222;9150135;9162092;9168116;9171241;9177240;9187114;9195981;9201922;9207108;9214382;9218805;9223305;9223306;9259561;9272954;9285814;9311981;9321410;9338790;9388265;9427644;9427705;9430628;9430729;9450758;9482740;9488439;9488723;9490669;9512513;9512523;9529249;9558366;9564042;9611253;9628874;9651585;9671459;9693032;9705271;9705289;9731700;9733514;9733515;9744270;9751710;9768359;9781043;9790531;9790534;9804427;9811839;9819412;9824166;9826654;9826763;9843217;9843967;9862427;9880483;9885572;9890904",
        "class_list": "",
        "function": "Data indicate that lactate dehydrogenase A (LDHA) is involved in the transcription of histone 2B gene., [RefSeq, PubMed]; Data show that histone H2B of prostate cancer cell line DU-145 have hypoacetylation, hypomethylation, and dephosphorylation, suggesting there was an excessive histone deacetylase activity in the cells. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]; In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B., [RefSeq, PubMed]; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R544;Q6NZ98;Q6NZA0;Q6NZA1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0042393 histone binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly;GO:0035092 sperm DNA condensation",
        "synthesized_glycan_count": 0,
        "hit_score": 126.0,
        "record_id": "Q96A08-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48357-1",
        "uniprot_id": [
            {
                "id": "LEPR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48357",
                "type": "external"
            }
        ],
        "mass": 132494.0,
        "length": 1165,
        "protein_name": "Leptin receptor",
        "gene_name": "LEPR",
        "organism": "Human",
        "refseq_name": "leptin receptor isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001003679",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003679",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LEPR; DB; OBR",
        "gene_names_refseq": "CD295; LEP-R; LEPRD; LEPR; OB-R; OBR; huB219",
        "protein_names_uniprotkb": "Leptin receptor; HuB219; LEP-R; OB receptor; OB-R",
        "protein_names_refseq": "OB receptor; leptin receptor isoform 3 precursor",
        "tax_id": 9606,
        "disease": "sleep apnea (Disease Ontology:DOID:0050847); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); short bowel syndrome (Disease Ontology:DOID:10605); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); arteriosclerosis (Disease Ontology:DOID:2349); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); hyperglycemia (Disease Ontology:DOID:4195); pancreatitis (Disease Ontology:DOID:4989); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diastolic heart failure (Disease Ontology:DOID:9775); obesity (Disease Ontology:DOID:9970); obesity due to leptin receptor gene deficiency (MONDO:MONDO:0013992)",
        "pathway": " (hsa:3953)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "10.1101/2023.09.13.557529;10449753;10896907;11018044;11342028;12504075;16052473;16335952;18668212;18987736;19159218;20058876;21516303;21698367;21887553;22127368;22405007;22792528;23090970;24275569;24834182;24935373;25060689;25232147;25261678;25261679;25422752;25751111;25863476;26634459;26992070;27466295;27862975;28190851;28723535;28834231;28938640;29391424;29453609;29557506;29731959;30192525;30429286;31848261;32157095;32350084;32938616;33592498;33968037;35051231;35251023;35580925;36215666;36284347;37074911;38522074;38637191;38843918;39062791;39201370;8548812;8616721;8666155;8805376;9061609;9144432;9158141;9175732;9287054;9537324;9600917;9786864;9860295;9929394",
        "class_list": "",
        "function": "A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers., [RefSeq, PubMed]; Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis., [UniProtKB, UniProtKB]; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3., [UniProtKB, UniProtKB]; Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:12504075, PubMed:25060689, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types. Publication Status: Online-Only, [RefSeq, PubMed]; The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease., [RefSeq, PubMed]; The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders., [RefSeq, PubMed]; The Expression of Genes Related to Reverse Cholesterol Transport and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells Are Decreased in Morbid Obesity and Related to Liver Function. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 18,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 13,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 19,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 19,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 71,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "",
        "glycan_count": 22,
        "disease_count": 28,
        "glyco_site_count": 20,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13592;Q13593;Q13594;Q92919;Q92920;Q92921",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0019953 sexual reproduction;GO:0007275 multicellular organism development;GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "P48357-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1000100001001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IZQ8-1",
        "uniprot_id": [
            {
                "id": "MYCD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZQ8",
                "type": "external"
            }
        ],
        "mass": 101997.0,
        "length": 938,
        "protein_name": "Myocardin",
        "gene_name": "MYOCD",
        "organism": "Human",
        "refseq_name": "myocardin isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001139784",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139784",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYOCD; MYCD",
        "gene_names_refseq": "MGBL; MYCD; MYOCD",
        "protein_names_uniprotkb": "Myocardin",
        "protein_names_refseq": "myocardin isoform 1",
        "tax_id": 9606,
        "disease": "congenital megabladder (Disease Ontology:DOID:0112014); aortic atherosclerosis (Disease Ontology:DOID:10230); dilated cardiomyopathy (Disease Ontology:DOID:12930); patent ductus arteriosus (Disease Ontology:DOID:13832); congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:93649);  (R-HSA-9733709)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "11237011;12397177;12640126;12920479;15095414;15907818;16054032;16141410;19479054;19776005;20385216;25187301;26783251;29636455;31513549;31844290;32387766;33054971;34087483;34932366;35051231;35913515;36010968;36241641;38349126;38824221;38858497",
        "class_list": "",
        "function": "Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin. Publication Status: Online-Only, [RefSeq, PubMed]; Myocardin is a critical serum response factor cofactor regulating smooth muscle cell differentiation; forced expression of myocardin activated expression of SM22 alpha, smooth muscle alpha-actin, and calponin-h1 genes in mouse ES cells, [RefSeq, PubMed]; Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors. Publication Status: Online-Only, [RefSeq, PubMed]; Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells., [RefSeq, PubMed]; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5UBU5;Q8N7Q1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042826 histone deacetylase binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0070412 R-SMAD binding;GO:0035035 histone acetyltransferase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0060379 cardiac muscle cell myoblast differentiation;GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045987 positive regulation of smooth muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q8IZQ8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23527-1",
        "uniprot_id": [
            {
                "id": "H2B1O_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23527",
                "type": "external"
            }
        ],
        "mass": 13906.0,
        "length": 126,
        "protein_name": "Histone H2B type 1-O",
        "gene_name": "H2BC17",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-O",
        "refseq_ac": [
            {
                "id": "NP_003518",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003518",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC17; H2BFH; H2BFN; HIST1H2BO",
        "gene_names_refseq": "H2B.2; H2B/n; H2BC17; H2BFN; HIST1H2BO; dJ193B12.2",
        "protein_names_uniprotkb": "Histone H2B type 1-O; H2B-clustered histone 17; H2B/n; Histone H2B.2; Histone H2B.n",
        "protein_names_refseq": "H2B histone family, member N; histone 1, H2bo; histone H2B type 1-O; histone H2B.2; histone H2B.n; histone cluster 1 H2B family member o; histone cluster 1, H2bo",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8348);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 59,
        "publication_count": 1244,
        "publication_id_list": "10029069;10037601;10074426;10080941;10097139;10199952;10204490;10233885;10319874;10323868;10330177;10330422;10347217;10391242;10411933;10425206;10432220;10438626;10444327;10444591;10449787;10471499;10485845;10500157;10548110;10550055;10551868;10558993;10562279;10562567;10572166;10583407;10617663;10655587;1066663;10669743;10706276;10722742;10724175;10728666;10734115;10748112;10757784;10766245;10769018;10772813;10775268;10777502;10786633;10802669;10821277;10828826;10831834;10835357;10859164;10866324;10871633;10873660;10882139;10882850;10904264;10921920;10922406;10926844;10928988;10930409;10956649;10959836;10970879;10973490;10978333;10982817;11010967;11025670;11027271;11034064;11050151;11056019;11080158;11080452;11103799;11114305;11114888;11136970;11136974;11139606;11165043;11204562;11242053;11242107;11274398;11278841;11292842;11301010;11340163;11340171;11345900;11356022;11369759;11376695;11390408;11390642;11401442;11410592;11452016;11454856;11467836;11493912;11507205;11509652;11532957;11564866;11566882;11571274;11573085;11581164;11590439;11604075;11673449;11682626;11684017;11702069;11713476;11739383;11740563;11741541;11742974;11744694;11747608;11830581;11847229;11867521;118839;11893489;11904416;11909966;11912130;11923872;11927591;11934263;11934988;11955432;11955446;11959841;11973335;11986212;11988739;12023295;12032298;12077346;12086618;12097317;12134156;12140329;12152085;12163411;12183469;12186630;12189133;12193592;12208845;12231622;12242300;12351676;12364621;12393752;12408966;12419226;12421820;12435631;12447390;12454989;12456671;12481029;12483298;12485996;12498683;12504854;12509254;12514133;12545175;12556884;12576332;12578958;12607003;12607005;12612073;12646563;12682017;12697768;12700765;12702500;1270801;12718543;12724404;12757711;12773400;12791985;12792649;12808055;12829629;12832467;12832489;12857923;12869508;12869583;12890688;12897153;12909626;12917689;12917691;12944405;12947387;12953102;12959972;1310260;13130130;13130464;14506261;14507994;14517214;14519844;14532106;14532133;14536086;14560035;14561766;14567678;14576433;14610093;14631847;14661020;14675539;14679213;14691562;14695187;14762106;14969726;14991602;15001666;15053880;15060161;15064394;15064416;15084397;15099518;15105426;15121853;15125634;15164066;15177042;15189136;15190204;15201865;15215855;15215856;15235794;15276198;15279782;15282324;15287722;15294866;15304223;15313887;15341901;15343269;15345050;15369670;15369671;15451442;15456747;15458641;15468306;15469825;15472075;15510216;15514030;15516265;15542832;15558034;15563468;15574327;15643423;15643425;15647753;15655109;15678106;15684396;15701600;15707391;15723659;15750587;15768032;15774718;15790808;15829968;15861382;15866172;15867264;15882967;15916963;15960975;15962837;15986123;16005293;16009131;16046058;16061182;16079151;16079795;16087863;16093244;16095617;16113099;16123081;16140760;16141325;16148040;16150728;16153896;16166375;16169192;16174740;16186106;16186825;16214042;16221681;16262255;16263726;16283522;16292313;16307923;1630819;16322221;16327781;16337592;16357870;16360315;16372014;16373483;16377563;16380219;16387653;16415179;16427009;16428440;16431907;16436515;16439204;16439205;16510874;16514417;16530042;16549775;16549788;16567619;16600297;16603238;16603771;16612405;16622420;16626623;16627869;16628190;16630820;16651405;16707490;16713563;16751774;16756492;16762929;16799559;16826196;16829525;16858402;16868077;16874298;16878130;16885023;16901786;16914548;16936726;16949368;16954381;16964248;16980581;17013392;17027977;17052462;17063141;17085592;17108083;17130289;17130829;17143291;17185360;17199038;17210787;17211407;17254968;17255097;17277772;17290220;17290226;17320160;17320161;17320163;17332741;17339379;17344414;17344417;17350655;17355984;17363312;17395714;17425515;17425782;17428788;17428831;17433364;17443180;17458864;17463000;17470781;17495528;17510434;17525332;17525340;17540598;17540599;17541404;17553757;17554337;17562868;1756725;17575048;17603073;17637753;17646674;17660710;17666587;17673620;17680271;17685488;17687327;1768865;17690249;17694070;17713478;17716973;17717186;17726030;17761849;17761950;17765224;17823410;17825402;17848578;17851529;17873522;17875933;17923702;17928296;17965729;17977839;17980597;17981138;17981954;18001824;18001825;18003914;18006705;18042460;18046455;18065497;18066052;18070888;18077395;18082607;18160704;18171670;18172164;18187655;18203656;18211953;18219272;18223688;18256232;18256600;18267069;18280240;18302924;18316480;18316726;1831692;18322535;18346456;18347063;18358809;18359941;18365017;18367646;1837051;18378692;18381289;18397950;18404694;18411265;18438399;18443292;18449172;18467330;18476782;18484335;18485871;1849145;18498752;18533032;18535008;18535146;18555777;18555778;18571423;18623064;18632802;18636086;18644861;18656484;18701449;18718915;18719106;18762174;18772889;18776924;18781158;18793328;18805091;18805503;18842624;18852463;18923075;18945682;18971343;18974356;18978028;19001364;19001859;19011241;19015242;19020303;19026781;19043829;19088198;19092802;19098913;19114653;19115252;19117993;19135894;19146767;19148484;19150886;19167051;19172745;19176521;19187765;19188362;19203578;19203579;19208625;19232136;19234442;1924375;19261749;19274700;19295514;19321454;19351884;19357644;19363159;19383337;19383768;19383769;19398495;19398555;19398759;19410543;19410544;19410545;19419957;19424180;19451217;19451218;19460168;19462008;19487454;19493659;19505854;19509293;19528227;19571010;19571879;19640981;19658395;19682613;19714243;19718048;19723507;19723635;19747919;1975088;19773441;19782031;19782034;19783983;19805069;19828817;19834512;19838211;19838300;19854132;19874889;19910467;20016603;20018852;20023648;20044539;20044541;20062530;20075857;20080577;20080834;20085832;20090754;20096447;20112406;20123894;20154705;20211137;20219941;20220067;20220130;20228808;20233725;2028256;20339092;20351093;20351172;20351173;20368735;20418909;20442293;20442780;20452968;20453063;20495621;20498280;20501646;20523938;20551165;20551166;20566683;20570965;20622854;20630873;20634189;20651253;20661648;20676056;20682797;20801121;20805998;20807650;20818382;20838592;20841325;20871592;20876458;20887958;20937877;20966048;20974918;21052091;21106759;21129147;21151129;21163962;21170310;2118650;21203937;21239494;21240188;21252065;21263215;21280156;21282113;21293379;21325134;21329877;21335604;21362556;21378119;21396873;21402699;21427083;21445275;21471526;21489993;21490301;21498573;21515671;21544310;21551231;21554508;21555516;21559432;21571218;21571647;21573489;21587264;21589992;21596315;21602795;21654818;21659512;21659603;21680713;21690215;21706000;21722948;21725049;21726809;21726816;21768289;21777809;21777816;21808299;21808300;2181374;2183031;21835891;21849505;21875955;21878914;21899694;21911480;21911577;21925322;21934649;21940756;2195544;21962518;21979375;21979949;21986495;21993314;22012064;22020331;22021381;22021426;22022377;22024395;22029577;22046413;22056668;22064703;22064859;22065755;22085928;22110129;22121020;22128162;22131221;22158034;22174689;22178396;22179609;22186018;22190459;22216260;22231403;22234877;22265404;22323599;22325352;22336108;22348533;22362753;22371011;22373579;22389435;22398447;22420752;22445173;22466170;22474248;22492511;22508508;22529269;22545144;22569126;22569366;22569481;22589545;22617422;22634325;22635276;22658674;22661229;22661230;22683641;22684280;22704330;22705304;22722852;22751019;22777353;22792074;22848106;22879880;22897851;22908299;22922743;22961379;22962365;22977173;22980979;22982193;23001182;23022729;23145106;23150874;23159851;23161542;23172872;23187890;23192763;23219899;23239876;23285124;2330041;23303788;23306437;23326524;23333306;23345434;23361464;23395819;23403292;23408615;2342578;23431328;23435229;23466526;23468639;23486064;23498719;23505375;23534758;23555303;23630040;23667505;23679895;23723241;23727112;23752590;23755964;23795651;23813966;23824326;23825189;23846687;23882114;23897426;23906331;2392154;24003239;2405250;24056413;24074865;24086155;2409350;24167369;24174538;24236237;24252660;24260525;24307175;24312487;24368767;24371278;24379003;24385926;24388755;24493797;24531329;24554700;24584857;24586203;24596094;24662292;24667604;24681537;24706756;24715725;24735615;24807418;24833601;24854081;24885040;24893886;24896179;24901984;24920672;24952918;24973012;24979766;24998469;25030448;25043025;25101834;25113031;25122754;25135475;25150861;25170678;25197364;25240135;2524830;25274305;25296600;25305019;25313066;25365482;25394790;25433557;25512557;25523424;25542856;25558984;25578727;25593184;25593309;25633194;25659039;25663755;25674852;25689043;2570724;25728767;25728771;25753662;25784553;25784653;25818648;25841101;25913784;25916849;25936802;26010396;26018760;26022416;26055325;26056233;26086376;26092250;26095805;26101246;26139588;26153859;26154972;26204489;26210183;26212009;26216882;26344566;26350214;26417681;26462610;26479350;26572645;26668317;26686862;26711259;26807092;26813693;26977885;27062924;27105113;27105115;27108190;27137657;2721961;27354518;27501258;27569044;27597759;27633282;27661449;27732843;27732854;27798111;27806305;27846572;27886276;279930;28273063;28404884;28415052;28533432;28539435;28581500;28854357;28977666;2900981;29042441;29101237;2919170;29211708;29431622;29608566;29728366;29729076;29795351;29902443;30045876;30122475;30134174;30154464;30228260;30327463;3035556;30360396;30385408;3045126;3053705;30599162;30761409;3080684;30898548;30923826;3094007;30980593;30993897;31086175;31289231;3142462;31427381;31542297;31645732;31746185;32183950;32188940;32350084;32387766;32808929;3281094;32860047;32976585;33009411;33177556;33264408;33283408;33298899;33329381;33608512;33717175;33801762;33912179;34105348;34171305;34357683;34545082;3484703;34874266;34961760;3498214;35008676;35138000;35215846;35292107;35314832;35851744;36008597;36172813;36215666;36284347;3675579;3677090;37217939;38359823;3886654;4054110;40914422;500690;6261960;6604055;7391081;7479006;7488013;7501971;7513682;7535770;7559524;7578059;7588633;7597036;7816143;7831296;7859739;7862113;7906964;7908827;7935485;7937828;7969165;8001816;8016081;8033412;8078588;8097946;8110764;8114934;8159701;8195246;8195709;8197458;8218289;8234276;8242751;8242752;8259215;8284199;8319905;8384717;8407958;8413215;8413306;8419924;8422676;8464497;8475094;8490014;8521497;8521498;8617720;8622669;8622688;8625414;8626550;8662714;8674428;8688489;8695841;8710908;874082;8741839;8756721;8757136;8759021;8769649;8774846;8794855;8846784;8846917;8870004;8876171;8878478;8884985;8929543;8939459;8944023;8955148;8974401;8991089;9006323;9008167;9016654;9030721;9054935;9065481;9118222;9150135;9162092;9168116;9171241;9177240;9187114;9195981;9201922;9207108;9214382;9218805;9223305;9223306;9259561;9272954;9285814;9311981;9321410;9338790;9388265;9427644;9427705;9430628;9430729;9450758;9482740;9488439;9488723;9490669;9512513;9512523;9529249;9558366;9564042;9611253;9628874;9651585;9671459;9693032;9705271;9705289;9731700;9733514;9733515;9744270;9751710;9768359;9781043;9790531;9790534;9804427;9811839;9819412;9824166;9826654;9826763;9843217;9843967;9862427;9880483;9885572;9890904",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KPI7;Q8TCV6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 125.0,
        "record_id": "P23527-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P18433-5",
        "uniprot_id": [
            {
                "id": "PTPRA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P18433",
                "type": "external"
            }
        ],
        "mass": 90719.0,
        "length": 802,
        "protein_name": "Receptor-type tyrosine-protein phosphatase alpha",
        "gene_name": "PTPRA",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002827",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002827",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRA; PTPA; PTPRL2",
        "gene_names_refseq": "HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; PTPRA; PTPRL2; R-PTP-alpha; RPTPA",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase alpha; 3.1.3.48; Protein-tyrosine phosphatase alpha; R-PTP-alpha",
        "protein_names_refseq": "Leukocyte common antigen-related peptide (protein tyrosine phosphate); PTPLCA-related phosphatase; PTPase-alpha; protein tyrosine phosphatase, receptor type, alpha polypeptide; protein-tyrosine phosphatase alpha; receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor; receptor-type tyrosine-protein phosphatase alpha; tyrosine phosphatase alpha",
        "tax_id": 9606,
        "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)",
        "pathway": " (hsa:5786);  (R-HSA-375165);  (R-HSA-5673001)",
        "pathway_count": 3,
        "publication_count": 121,
        "publication_id_list": "10.1101/2023.09.13.557529;10508167;10698938;10869344;11027663;11090077;11136978;11313946;11546808;11676480;11702783;11923305;12032311;12094235;12121613;12700044;12826681;14506247;14707138;15356145;1545823;15546878;16497976;16627759;16684964;17016520;17081983;1716764;17389395;17998941;18578522;18775330;18809727;1898771;19279408;19651622;19690332;19920141;20068231;20385765;20478380;21102635;21372320;2169617;2170109;2172030;2175890;21779497;21779505;21993244;22569528;22589270;22750304;22801373;23103841;23186163;23303910;23443682;23575685;24190977;24275569;24897931;24937142;25219551;25781681;26085527;26992070;2809592;28467828;28778966;28832583;29242379;29314611;29317506;29351928;29493099;29557506;29632711;30573663;31020640;31092671;31135801;31844290;32157095;32350084;32357974;32387766;32938616;32983136;33298915;33592498;33912179;33936100;33968037;33981976;34087483;34357683;34509645;35051231;35154160;35251023;35561310;35900966;36228153;36765146;40596516;6148751;7518772;7809086;7935463;7972015;7997267;8052307;8394845;8493579;8665852;8710374;8939933;9604935;9687510;9927426",
        "class_list": "",
        "function": "Does a rare mutation in PTPRA contribute to the development of Parkinson's disease in an Australian multi-incident family? Publication Status: Online-Only, [RefSeq, PubMed]; Glucose-mediated N-glycosylation of RPTPalpha affects its subcellular localization and Src activation., [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]; Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2G8;D3DVX5;Q14513;Q7Z2I2;Q96TD9",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0043235 receptor complex;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P18433-5",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IZU9-1",
        "uniprot_id": [
            {
                "id": "KIRR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZU9",
                "type": "external"
            }
        ],
        "mass": 85255.0,
        "length": 778,
        "protein_name": "Kin of IRRE-like protein 3",
        "gene_name": "KIRREL3",
        "organism": "Human",
        "refseq_name": "kin of IRRE-like protein 3 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001155179",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155179",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIRREL3; KIAA1867; NEPH2; PRO19814",
        "gene_names_refseq": "KIRREL3; KIRRE; MRD4; NEPH2; PRO4502",
        "protein_names_uniprotkb": "Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2",
        "protein_names_refseq": "kin of IRRE like 3; kin of IRRE-like protein 3 isoform 2 precursor; kin of IRRE-like protein 3; kin of irregular chiasm-like protein 3; nephrin-like 2; nephrin-like protein 2",
        "tax_id": 9606,
        "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:84623);  (R-HSA-373753)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10393930;10541305;10611248;11237011;11340081;11562357;11733557;12424224;12660326;12668668;12846735;12865409;12975309;14570703;14633607;15331416;15545998;15579503;15634346;15843475;15994232;16525419;16543952;16630808;17893108;17923684;18033240;19012874;19443634;19615748;20233749;25488023;25902260;28228285;31530632;35051231;35580925;35863131;37977826",
        "class_list": "",
        "function": "Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported., [RefSeq, PubMed]; KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Modular Splicing Is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3. Publication Status: Online-Only, [RefSeq, PubMed]; Preliminary study on the role and mechanism of KIRREL3 in the development of esophageal squamous cell carcinoma., [RefSeq, PubMed]; Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MIJ7;Q6UWJ9;Q6UWL5;Q96JG0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050839 cell adhesion molecule binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0030424 axon",
        "go_biological_process": "GO:0021766 hippocampus development;GO:0098609 cell-cell adhesion;GO:0007416 synapse assembly;GO:0030097 hemopoiesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q8IZU9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UGQ3-1",
        "uniprot_id": [
            {
                "id": "GTR6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UGQ3",
                "type": "external"
            }
        ],
        "mass": 54539.0,
        "length": 507,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 6",
        "gene_name": "SLC2A6",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001138571",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138571",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC2A6; GLUT6",
        "gene_names_refseq": "GLUT6; GLUT9; HSA011372; SLC2A6",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 6; GLUT-6; Glucose transporter type 6",
        "protein_names_refseq": "GLUT-6; GLUT-9; glucose transporter type 6; glucose transporter type 9; solute carrier family 2 (facilitated glucose transporter), member 6; solute carrier family 2, facilitated glucose transporter member 6 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11182);  (R-HSA-189200)",
        "pathway_count": 2,
        "publication_count": 95,
        "publication_id_list": "10821868;10860667;10970791;10987651;11133510;11237011;11245466;11247674;11425315;11583593;11681785;11741323;11780755;11832379;11994746;12504846;12590146;12885248;1415574;14614622;14739288;14997204;15033637;15607332;15902306;16154905;16303743;16550171;17050778;1756912;17635959;18063724;18327257;18691976;1918382;19554504;20413573;20616166;21107422;21940664;22212718;22521588;23328677;25576301;25892735;2656669;26650681;26992070;27846572;28063628;28218747;28228285;28467828;28514659;28832583;28834231;28904123;29242379;29314611;29437277;29632046;29769354;30315122;30410026;30431159;30573663;30626607;30779550;31154438;31530632;31844290;32157095;32161166;32350084;32357974;32502341;32512041;32938616;32983136;33298915;33537174;33592498;33912179;33968037;34019948;34357683;34932366;35051231;35154160;35580925;36010968;36327817;8457197;9354798;9751501",
        "class_list": "glycogene",
        "function": "Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose (PubMed:30431159)., [UniProtKB, PubMed]; SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma., [RefSeq, PubMed]; The NF-kappaB signalling pathway regulates GLUT6 expression in endometrial cancer., [RefSeq, PubMed]; The expression pattern of GLUT9 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 687,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNU6;Q5SXD7;Q8NCC2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0006110 regulation of glycolytic process;GO:0055085 transmembrane transport;GO:0015755 fructose transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "Q9UGQ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010001.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P52790-1",
        "uniprot_id": [
            {
                "id": "HXK3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P52790",
                "type": "external"
            }
        ],
        "mass": 99025.0,
        "length": 923,
        "protein_name": "Hexokinase-3",
        "gene_name": "HK3",
        "organism": "Human",
        "refseq_name": "hexokinase-3",
        "refseq_ac": [
            {
                "id": "NP_002106",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002106",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HK3",
        "gene_names_refseq": "HK3; HKIII; HXK3",
        "protein_names_uniprotkb": "Hexokinase-3; 2.7.1.1; HK III; Hexokinase type III; Hexokinase-C",
        "protein_names_refseq": "ATP:D-hexose 6-phosphotransferase; HK III; hexokinase 3 (white cell); hexokinase type III; hexokinase-3; hexokinase-C",
        "tax_id": 9606,
        "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); neonatal diabetes mellitus (Disease Ontology:DOID:11717); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); glucose metabolism disease (Disease Ontology:DOID:4194); hyperglycemia (Disease Ontology:DOID:4195)",
        "pathway": " (hsa:3101);  (R-HSA-6798695);  (R-HSA-70171)",
        "pathway_count": 3,
        "publication_count": 71,
        "publication_id_list": "10714828;11237011;11371164;11506403;11780755;12616532;1278465;12965206;13538944;15710582;16511037;16959974;17804405;183598;1871135;18910716;18910717;18927083;22219026;23168256;23446454;23650620;2462567;25648650;27862975;2793178;2846554;29242379;29557506;2960695;30517626;3170585;3208766;32983136;33123756;3355497;33968037;34239350;3453121;34782236;35051231;3529090;35538058;35580925;36010968;38687460;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7717389;7825568;7989588;8117307;8325892;8447317;8692836;8717435;8786021;8812439;9438414;9493266",
        "class_list": "glycogene",
        "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435)., [UniProtKB, PubMed]; Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltration., [RefSeq, PubMed]; Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Publication Status: Online-Only, [RefSeq, PubMed]; Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1333,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N1E7",
        "ec_number_list": [
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "2.4.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "5.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9",
                "type": "external"
            },
            {
                "id": "5.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-",
                "type": "external"
            },
            {
                "id": "3.4.23.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5",
                "type": "external"
            },
            {
                "id": "3.4.22.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52",
                "type": "external"
            },
            {
                "id": "2.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            },
            {
                "id": "1.13.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34",
                "type": "external"
            },
            {
                "id": "3.3.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6",
                "type": "external"
            },
            {
                "id": "3.4.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "4.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24",
                "type": "external"
            },
            {
                "id": "3.4.19.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1",
                "type": "external"
            },
            {
                "id": "5.3.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1",
                "type": "external"
            },
            {
                "id": "5.3.3.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            },
            {
                "id": "5.4.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11",
                "type": "external"
            },
            {
                "id": "5.4.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4",
                "type": "external"
            },
            {
                "id": "2.7.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1",
                "type": "external"
            },
            {
                "id": "2.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "3.5.4.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5",
                "type": "external"
            },
            {
                "id": "5.4.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2",
                "type": "external"
            },
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.5.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6",
                "type": "external"
            },
            {
                "id": "1.11.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.5.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.109",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.109",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.4.18.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
                "type": "external"
            },
            {
                "id": "4.1.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0034774 secretory granule lumen;GO:1904813 ficolin-1-rich granule lumen",
        "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "P52790-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48382-1",
        "uniprot_id": [
            {
                "id": "RFX5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48382",
                "type": "external"
            }
        ],
        "mass": 65323.0,
        "length": 616,
        "protein_name": "DNA-binding protein RFX5",
        "gene_name": "RFX5",
        "organism": "Human",
        "refseq_name": "DNA-binding protein RFX5 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000440",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000440",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RFX5",
        "gene_names_refseq": "MHC2D3; MHC2D5; RFX5",
        "protein_names_uniprotkb": "DNA-binding protein RFX5; Regulatory factor X 5",
        "protein_names_refseq": "DNA-binding protein RFX5 isoform 1; DNA-binding protein RFX5; regulatory factor X 5; regulatory factor X, 5 (influences HLA class II expression)",
        "tax_id": 9606,
        "disease": "severe combined immunodeficiency (Disease Ontology:DOID:627); MHC class II deficiency 3 (MONDO:MONDO:0971014); MHC class II deficiency 5 (MONDO:MONDO:0971016)",
        "pathway": " (hsa:5993)",
        "pathway_count": 1,
        "publication_count": 80,
        "publication_id_list": "10072068;10779326;10825209;11237011;15253423;18507432;20068231;20732328;22649097;23186163;23301498;23481700;24129315;25576301;25645385;25880248;26992070;27846572;27920218;28063628;28218747;28228285;28832583;28904123;29242379;29393594;29437277;29485866;29508533;29557506;29632046;30059200;30170160;30315122;30379171;30410026;30429286;30484775;30620550;31492838;31530632;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32574038;32883983;32938616;32952112;33298915;33592498;33936100;33968037;33981976;34019948;34509645;34561969;34846842;34932366;35051231;35132862;35254053;35289036;35513511;35705054;36010968;36045400;37340703;37541260;37584719;38665916;39302247;39531497;40307207;40596516;7744245;9401005",
        "class_list": "",
        "function": "A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters., [UniProtKB]; Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A. Publication Status: Online-Only, [RefSeq, PubMed]; RFX5 regulates gene expression of the Pcdhalpha cluster., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z848;D3DV19;E9PFU4;Q5VWC3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045348 positive regulation of MHC class II biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "P48382-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HA64-1",
        "uniprot_id": [
            {
                "id": "KT3K_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HA64",
                "type": "external"
            }
        ],
        "mass": 34412.0,
        "length": 309,
        "protein_name": "Ketosamine-3-kinase",
        "gene_name": "FN3KRP",
        "organism": "Human",
        "refseq_name": "ketosamine-3-kinase",
        "refseq_ac": [
            {
                "id": "NP_078895",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078895",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FN3KRP",
        "gene_names_refseq": "FN3KL; FN3KRP",
        "protein_names_uniprotkb": "Ketosamine-3-kinase; 2.7.1.-; 2.7.1.172; FN3K-RP; FN3K-related protein; Fructosamine-3-kinase-related protein; Protein-psicosamine 3-kinase FN3KRP",
        "protein_names_refseq": "FN3K-related protein; ketosamine-3-kinase; protein-psicosamine 3-kinase FN3KRP; protein-ribulosamine 3-kinase; testis secretory sperm-binding protein Li 211a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79672);  (R-HSA-163841)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "11016445;11230166;11237011;14633848;15102834;15137908;15331600;15381090;1554716;16037310;16920277;18212344;18637789;18672380;19158273;19369195;22195972;23481380;23481700;24971579;25059662;25505266;25576301;25645385;26992070;27846572;28218747;28510447;28832583;28834231;29242379;29393594;29437277;29493099;29508533;29632046;29786170;30315122;30779550;31154438;31844290;31848261;32157095;32357974;32387766;32502341;32938616;33298915;33392160;33491046;33537174;33592498;33936100;33968037;34185709;34211107;34229054;34509645;35580925;36010968;36241641;36580660;37938771;38665916;8051097;9501187",
        "class_list": "",
        "function": "A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]., [RefSeq]; Enzyme is a constitutive 'housekeeping' gene and that ig plays an important role in cell metabolism, possibly as a deglycating enzyme., [RefSeq, PubMed]; Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes., [RefSeq, PubMed]; In this paper we propose a resolution of both these quandaries by proposing that fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by FN3KRP and/or possibly FN3K., [RefSeq, PubMed]; Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848, PubMed:15137908). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848, PubMed:15137908). Not able to phosphorylate fructoselysine (PubMed:14633848)., [UniProtKB, PubMed, PubMed]; Studies provide evidence that Fn3KRP possesses an ATP-binding domain that is structurally related to that of both the aminoglycoside kinases and eukaryotic protein kinases., [RefSeq, PubMed]; These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q969F4;Q9H0U7",
        "ec_number_list": [
            {
                "id": "2.7.1.172",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.172",
                "type": "external"
            },
            {
                "id": "2.7.1.171",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.171",
                "type": "external"
            },
            {
                "id": "2.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0102193 protein-ribulosamine 3-kinase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0043687 post-translational protein modification",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q9HA64-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P02042-1",
        "uniprot_id": [
            {
                "id": "HBD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P02042",
                "type": "external"
            }
        ],
        "mass": 16055.0,
        "length": 147,
        "protein_name": "Hemoglobin subunit delta",
        "gene_name": "HBD",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit delta",
        "refseq_ac": [
            {
                "id": "NP_000510",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000510",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBD",
        "gene_names_refseq": "HBD; HBK",
        "protein_names_uniprotkb": "Hemoglobin subunit delta; Delta-globin; Hemoglobin delta chain",
        "protein_names_refseq": "delta globin; delta-globin chain; hemoglobin delta chain; hemoglobin subunit delta; hemoglobin, delta",
        "tax_id": 9606,
        "disease": "beta thalassemia (Disease Ontology:DOID:12241); anemia (Disease Ontology:DOID:2355)",
        "pathway": " (hsa:3045);  (R-HSA-983231)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "11042108;11062261;11237011;11242053;1148221;11744692;11751636;11895428;11939506;11950885;12032298;12134158;12402333;12427746;15020713;15247287;15449937;15710388;15921167;16054028;1630448;16370490;16370491;17027967;17145605;17196961;1742490;1787103;17975675;1802883;18566446;18984734;19117535;19293402;20530532;20627800;2066116;218813;23555621;24275569;2477064;25502872;26811146;26845023;27726376;27893789;28228285;2869009;28904123;29493099;29508533;29557506;29786170;29789417;30429286;30573663;31154438;31844290;31848261;32157095;32357974;32387766;32983136;33043033;33091337;33141586;33298915;33912179;33968037;34046885;3409321;34171305;34341901;34357683;34561969;35051231;35251023;35580925;36214153;36215666;36284347;37548329;37605839;37938771;3841531;4850239;4995018;5678016;5824070;5956309;6469695;6548205;6629825;6629826;680638;7129931;7438204;7713748;8330984;8364213;8401543;8537235;8662638;8816476;9065479;9101295;9230307;9326583;9331217;9422515;952968;9927674",
        "class_list": "",
        "function": "Analysis of delta-globin gene alleles in Tunisians: description of three new delta-thalassemia mutations., [RefSeq, PubMed]; Delta-globin gene expression improves sickle cell disease in a humanised mouse model., [RefSeq, PubMed]; Detecting rare thalassemia in children with anemia using third-generation sequencing., [RefSeq, PubMed]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]; Molecular characterization of a novel homozygous deletion in beta-globin cluster causing (deltabeta)[0]-Thalassemia among Tunisian family., [RefSeq, PubMed]; Mutational spectrum of HBD gene in the Chinese population: Description of 36 mutations including 11 novel variants., [RefSeq, PubMed]; The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3Y5H3;Q8WXT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0072562 blood microparticle;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex",
        "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "P02042-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RR4-1",
        "uniprot_id": [
            {
                "id": "KKCC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RR4",
                "type": "external"
            }
        ],
        "mass": 64746.0,
        "length": 588,
        "protein_name": "Calcium/calmodulin-dependent protein kinase kinase 2",
        "gene_name": "CAMKK2",
        "organism": "Human",
        "refseq_name": "calcium/calmodulin-dependent protein kinase kinase 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001257414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CAMKK2; CAMKKB; KIAA0787",
        "gene_names_refseq": "CAMKK2; CAMKKB; CAMKK",
        "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase kinase 2; 2.7.11.17; CaM-KK 2; CaM-KK beta; CaM-kinase kinase 2; CaM-kinase kinase beta; CaMKK 2; CaMKK beta; Calcium/calmodulin-dependent protein kinase kinase beta",
        "protein_names_refseq": "CAMKK beta protein; caM-KK 2; caM-KK beta; caM-kinase kinase 2; caM-kinase kinase beta; calcium/calmodulin-dependent protein kinase beta; calcium/calmodulin-dependent protein kinase kinase 2 isoform 1; calcium/calmodulin-dependent protein kinase kinase 2, beta",
        "tax_id": 9606,
        "disease": "high grade glioma (Disease Ontology:DOID:3070)",
        "pathway": " (hsa:10645);  (R-HSA-111932);  (R-HSA-442729);  (R-HSA-9619229);  (R-HSA-9619483)",
        "pathway_count": 5,
        "publication_count": 82,
        "publication_id_list": "11237011;11395482;12935886;15209507;15591024;16054095;17344846;18669648;18691976;19664994;20058876;21669867;21859090;21957496;22778263;23186163;23301498;23328677;23481700;24275569;24715725;25418920;25576301;25880248;25892735;26395653;26992070;27600516;27846572;27920218;28218747;28228285;28230171;28514659;28657654;28832583;28834231;29242379;29393594;29493099;29508533;29557506;29649512;29769354;29786170;29914450;30315122;30429286;30524438;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32869834;32897882;32913128;32938616;32983136;33141586;33298915;33392160;33717175;33912179;33936100;33968037;34932366;35051231;35580925;36581221;37166584;37335130;37730845;37938771;38469147;38755664;7641687;8702940;9662074;9822657",
        "class_list": "",
        "function": "Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKbeta in diabetic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; CaMKK2 as an emerging treatment target for bipolar disorder. Review article, [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy., [RefSeq, PubMed]; Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis., [RefSeq, PubMed]; The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]., [RefSeq]; There is a significant basal activity and phosphorylation of AMPK in LKB1-deficient cells that can be stimulated by Ca2+ ionophores, and studies using the CaMKK inhibitor STO-609 and isoform-specific siRNAs show that CaMKKbeta is required for this effect, [RefSeq, PubMed]; Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7Q7;O94883;Q8IUG2;Q8IUG3;Q8N3I4;Q8WY03;Q8WY04;Q8WY05;Q8WY06;Q96RP1;Q96RP2;Q96RR3;Q9BWE9;Q9UER3;Q9UES2;Q9Y5N2",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043005 neuron projection",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0019722 calcium-mediated signaling;GO:0000165 MAPK cascade;GO:0045893 positive regulation of DNA-templated transcription;GO:0046777 protein autophosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q96RR4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6AI08-1",
        "uniprot_id": [
            {
                "id": "HEAT6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6AI08",
                "type": "external"
            }
        ],
        "mass": 128781.0,
        "length": 1181,
        "protein_name": "HEAT repeat-containing protein 6",
        "gene_name": "HEATR6",
        "organism": "Human",
        "refseq_name": "HEAT repeat-containing protein 6",
        "refseq_ac": [
            {
                "id": "NP_071353",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071353",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR6; ABC1",
        "gene_names_refseq": "ABC1; HEATR6",
        "protein_names_uniprotkb": "HEAT repeat-containing protein 6; Amplified in breast cancer protein 1",
        "protein_names_refseq": "HEAT repeat-containing protein 6; amplified in breast cancer 1; amplified in breast cancer protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63897)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "11237011;11431322;18669648;18691976;18707149;19413330;19651622;19664994;19664995;19690332;20058876;20068231;23186163;23301498;24715725;25576301;26992070;29437277;29493099;29557506;30410026;31844290;32157095;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;33981976;34019948;34087483;34185709;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36284347;37246005",
        "class_list": "",
        "function": "Amplification-dependent oncogene., [UniProtKB]; [The relationship between the expression of amplified in breast cancer 1androgen receptor and tamoxifen resistance in breast cancer]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXP3;Q6MZX1;Q6MZY2;Q8TDM9;Q9H6B3;Q9H6M7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q6AI08-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z4H3-1",
        "uniprot_id": [
            {
                "id": "HDDC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z4H3",
                "type": "external"
            }
        ],
        "mass": 23390.0,
        "length": 204,
        "protein_name": "5'-deoxynucleotidase HDDC2",
        "gene_name": "HDDC2",
        "organism": "Human",
        "refseq_name": "5'-deoxynucleotidase HDDC2",
        "refseq_ac": [
            {
                "id": "NP_057147",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057147",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HDDC2; C6orf74; CGI-130; NS5ATP2",
        "gene_names_refseq": "C6orf74; CGI-130; HDDC2; NS5ATP2; dJ167O5.2",
        "protein_names_uniprotkb": "5'-deoxynucleotidase HDDC2; 3.1.3.89; HCV NS5A-transactivated protein 2; HD domain-containing protein 2; Hepatitis C virus NS5A-transactivated protein 2",
        "protein_names_refseq": "5'-deoxynucleotidase HDDC2; HCV NS5A-transactivated protein 2; HD domain-containing protein 2; hepatitis C virus NS5A-transactivated protein 2; testicular tissue protein Li 83",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51020)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;15188496;20877624;23186163;23481700;24397554;25576301;26811146;26992070;28510447;28904123;29242379;29393594;30315122;30779550;31844290;31848261;32157095;32357974;33298915;33592498;33912179;33968037;33981976;34932366;35251023",
        "class_list": "",
        "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)., [UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TDQ4;Q6NZ49;Q9BTT2;Q9BV31;Q9Y3D1",
        "ec_number_list": [
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.91",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91",
                "type": "external"
            },
            {
                "id": "3.1.3.89",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89",
                "type": "external"
            },
            {
                "id": "3.1.3.99",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99",
                "type": "external"
            },
            {
                "id": "3.1.3.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0002953 5'-deoxynucleotidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0009159 deoxyribonucleoside monophosphate catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q7Z4H3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16719-1",
        "uniprot_id": [
            {
                "id": "KYNU_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16719",
                "type": "external"
            }
        ],
        "mass": 52352.0,
        "length": 465,
        "protein_name": "Kynureninase",
        "gene_name": "KYNU",
        "organism": "Human",
        "refseq_name": "kynureninase isoform b",
        "refseq_ac": [
            {
                "id": "NP_001028170",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028170",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KYNU",
        "gene_names_refseq": "KYNUU; KYNU; VCRL2",
        "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; L-kynurenine hydrolase",
        "protein_names_refseq": "kynureninase isoform b",
        "tax_id": 9606,
        "disease": "hydroxykynureninuria (Disease Ontology:DOID:0112257); hypertension (Disease Ontology:DOID:10763); vertebral, cardiac, renal, and limb defects syndrome 2 (MONDO:MONDO:0060555)",
        "pathway": " (hsa:8942);  (R-HSA-71240)",
        "pathway_count": 2,
        "publication_count": 96,
        "publication_id_list": "10049700;10391915;10672018;11237011;11985583;12007602;12140278;13069505;15364907;15880762;16376499;16477023;17300176;17334708;17671174;18056995;18262359;18620547;19338303;20068231;21097500;23478338;24715725;25548167;25802875;25892735;26992070;27090790;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28514659;28792876;28832583;28904123;29242379;29393594;29437277;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30779550;30833945;31092671;31332944;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33214551;33298915;33592498;33691108;33717175;33936100;33968037;34051337;34087483;34171305;34211107;34357683;34932366;35051231;35054825;35251023;35362267;35561310;35580925;36215666;36241641;36284347;36581221;37938771;7514594;7883047;8294935;8666386;8706755;9180257",
        "class_list": "",
        "function": "A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer., [RefSeq, PubMed]; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]., [RefSeq]; Re-sequencing of candidate genes FOXF1, HSPA6, HAAO, and KYNU in 522 individuals with VATER/VACTERL, VACTER/VACTERL-like association, and isolated anorectal malformation., [RefSeq, PubMed]; TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway., [RefSeq, PubMed]; The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCZ5;D3DP79;Q6I9T2;Q9BVW3",
        "ec_number_list": [
            {
                "id": "3.7.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0030429 kynureninase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006569 L-tryptophan catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0009435 NAD+ biosynthetic process;GO:0019805 quinolinate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q16719-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22830-1",
        "uniprot_id": [
            {
                "id": "HEMH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22830",
                "type": "external"
            }
        ],
        "mass": 47862.0,
        "length": 423,
        "protein_name": "Ferrochelatase, mitochondrial",
        "gene_name": "FECH",
        "organism": "Human",
        "refseq_name": "ferrochelatase, mitochondrial isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_000131",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000131",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FECH",
        "gene_names_refseq": "EPP1; EPP; FCE; FECH",
        "protein_names_uniprotkb": "Ferrochelatase, mitochondrial; 4.98.1.1; Heme synthase; Protoheme ferro-lyase",
        "protein_names_refseq": "ferrochelatase, mitochondrial isoform b precursor; ferrochelatase, mitochondrial; heme synthase; heme synthetase; protoheme ferro-lyase; protoporphyria; protoporphyrin ferrochelatase",
        "tax_id": 9606,
        "disease": "renal fibrosis (Disease Ontology:DOID:0050855); COVID-19 (Disease Ontology:DOID:0080600); nephritis (Disease Ontology:DOID:10952); Chagas disease (Disease Ontology:DOID:12140); alcoholic hepatitis (Disease Ontology:DOID:12351); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); crescentic glomerulonephritis (Disease Ontology:DOID:13139); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); anterior uveitis (Disease Ontology:DOID:1407); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); acute kidney failure (Disease Ontology:DOID:3021); systemic scleroderma (Disease Ontology:DOID:418); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (hsa:2235);  (R-HSA-189451);  (R-HSA-9837999)",
        "pathway_count": 3,
        "publication_count": 101,
        "publication_id_list": "10706561;10942404;11032836;11032841;11175906;11237011;11375302;11923310;12063482;12198491;12474143;12601550;12773194;1376018;14623864;15235026;15286165;15522782;15863660;15870080;16115876;16121195;16176984;16258391;17101804;17196862;17261801;17297443;1755842;17579211;1939222;19841671;20705604;22262461;2260980;22710082;23201127;23467411;23931759;24315374;24520911;26504172;26923599;26992070;27496948;27599036;27642048;27846572;27920218;28377575;28396416;28510447;28553927;28832583;28834231;29301859;29393594;29557506;29932645;30120231;30379171;30429286;30765471;31217245;31327635;31611695;31695197;31844290;31848261;32157095;32938616;33257573;34171305;34686726;34704252;34943861;35051231;35870450;36629048;3805019;39202434;666752;6822570;7354069;7592565;7623837;7910885;7983009;8078902;8159699;8276824;8644733;8757534;8771201;8973195;9177788;9211198;9585598;9712849;9740232;9878253",
        "class_list": "",
        "function": "Catalyzes the ferrous insertion into protoporphyrin IX and participates in the terminal step in the heme biosynthetic pathway., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the ferrous insertion into protoporphyrin IX., [UniProtKB, UniProtKB]; Key Genes FECH and ALAS2 under Acute High-Altitude Exposure: A Gene Expression and Network Analysis Based on Expression Profile Data. Publication Status: Online-Only, [RefSeq, PubMed]; Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness. Erratum:[Sci Rep. 2021 Dec 14;11(1):24258. doi: 10.1038/s41598-021-03094-1. PMID: 34907222] Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 18,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA72;Q8IXN1;Q8NAN0",
        "ec_number_list": [
            {
                "id": "2.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1",
                "type": "external"
            },
            {
                "id": "7.1.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "1.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3",
                "type": "external"
            },
            {
                "id": "1.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3",
                "type": "external"
            },
            {
                "id": "6.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3",
                "type": "external"
            },
            {
                "id": "7.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2",
                "type": "external"
            },
            {
                "id": "4.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2",
                "type": "external"
            },
            {
                "id": "1.2.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1",
                "type": "external"
            },
            {
                "id": "1.8.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4",
                "type": "external"
            },
            {
                "id": "5.6.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7",
                "type": "external"
            },
            {
                "id": "2.3.1.168",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37",
                "type": "external"
            },
            {
                "id": "4.98.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1",
                "type": "external"
            },
            {
                "id": "1.1.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "1.2.1.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36",
                "type": "external"
            },
            {
                "id": "1.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-",
                "type": "external"
            },
            {
                "id": "1.2.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.1.1.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37",
                "type": "external"
            },
            {
                "id": "5.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8",
                "type": "external"
            },
            {
                "id": "1.3.8.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1",
                "type": "external"
            },
            {
                "id": "1.3.8.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "1.1.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41",
                "type": "external"
            },
            {
                "id": "2.3.3.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10",
                "type": "external"
            },
            {
                "id": "2.8.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.2.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2",
                "type": "external"
            },
            {
                "id": "1.1.1.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.7.11.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "3.4.21.92",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92",
                "type": "external"
            },
            {
                "id": "1.1.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35",
                "type": "external"
            },
            {
                "id": "2.7.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "1.1.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62",
                "type": "external"
            },
            {
                "id": "1.1.1.239",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239",
                "type": "external"
            },
            {
                "id": "1.1.1.178",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178",
                "type": "external"
            },
            {
                "id": "1.1.1.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53",
                "type": "external"
            },
            {
                "id": "1.1.1.159",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159",
                "type": "external"
            },
            {
                "id": "4.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3",
                "type": "external"
            },
            {
                "id": "6.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5",
                "type": "external"
            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0030350 iron-responsive element binding;GO:0008198 ferrous iron binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0009416 response to light stimulus;GO:0006783 heme biosynthetic process;GO:0046501 protoporphyrinogen IX metabolic process;GO:0006784 heme A biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "P22830-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NBJ5-1",
        "uniprot_id": [
            {
                "id": "GT251_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NBJ5",
                "type": "external"
            }
        ],
        "mass": 71636.0,
        "length": 622,
        "protein_name": "Procollagen galactosyltransferase 1",
        "gene_name": "COLGALT1",
        "organism": "Human",
        "refseq_name": "procollagen galactosyltransferase 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_078932",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078932",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "COLGALT1; GLT25D1; PSEC0241",
        "gene_names_refseq": "BSVD3; COLGALT1; ColGalT 1; GLT25D1",
        "protein_names_uniprotkb": "Procollagen galactosyltransferase 1; 2.4.1.50; ColGalT 1; Collagen beta(1-O)galactosyltransferase 1; Glycosyltransferase 25 family member 1; Hydroxylysine galactosyltransferase 1",
        "protein_names_refseq": "glycosyltransferase 25 domain containing 1; glycosyltransferase 25 family member 1; hydroxylysine galactosyltransferase 1; procollagen galactosyltransferase 1 precursor; procollagen galactosyltransferase 1",
        "tax_id": 9606,
        "disease": "brain small vessel disease 3 (Disease Ontology:DOID:0112315)",
        "pathway": " (hsa:79709);  (R-HSA-1650814)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10479448;10934207;11237011;12473679;12475640;12646579;1323838;14500733;15044469;1577494;16303743;16591531;18487197;19075007;19159218;19693541;20068231;20470363;21878990;21967573;22216269;22661428;23090970;23481700;23584533;24190977;2543975;25576301;25645385;26992070;27402836;27452731;27846572;27862975;27920218;28218747;28228285;28428430;28514659;28834231;28904123;29242379;29393594;29437277;29493099;29632046;29632711;29741879;29786170;30315122;30412317;30524438;30779550;31154438;31217245;31222486;31611695;3173483;31844290;31848261;31998317;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33936100;33968037;33984770;34019948;34078123;34171305;34357683;34725712;35008409;35051231;35251023;35561310;35580925;36010968;36215666;37074911;37217939;38665916;3905801;3938630;40914422;6307276;6809411;710450;9054364;9545296;9560306;9582318",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data indicate that galactosylation of collagenous proteins by the soluble GLT25D1 occurs in the early secretory pathway Publication Status: Online-Only, [RefSeq, PubMed]; GLT25D1 regulates HMW adiponectin secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Introduced substitution Q471R-V472M-N473Q-P474V in the CEECAM1-C-terminal construct, which is found in most animal GLT25D1 and GLT25D2 isoforms but not in CEECAM1. This substitution was shown to partially restore collagen galactosyltransferase activity, [RefSeq, PubMed]; Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1., [RefSeq, PubMed]; Loss of GLT25D1 led to increased expression and intracellular accumulation of collagen type I, whereas loss of GLT25D2 had no effect on collagen secretion. Inactivation of the GLT25D1 gene resulted in a compensatory induction of GLT25D2 expression., [RefSeq, PubMed]; The protein encoded by this gene is one of two enzymes that transfers galactose moieties to hydroxylysine residues of collagen and mannose binding lectin. This gene is constitutively expressed and encodes a soluble protein that localizes to the endoplasmic reticulum. [provided by RefSeq, Dec 2015]., [RefSeq]; Two collagen beta(1-O)galactosyltransferases corresponding to the GLT25D1 and GLT25D2 proteins were identified., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 848,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 31,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NC64",
        "ec_number_list": [
            {
                "id": "2.4.1.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50",
                "type": "external"
            },
            {
                "id": "1.14.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4",
                "type": "external"
            },
            {
                "id": "2.4.1.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane",
        "go_biological_process": "GO:0030199 collagen fibril organization;GO:1904028 positive regulation of collagen fibril organization;GO:0180062 protein O-linked glycosylation via galactose",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "Q8NBJ5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBH0-1",
        "uniprot_id": [
            {
                "id": "I36RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBH0",
                "type": "external"
            }
        ],
        "mass": 16962.0,
        "length": 155,
        "protein_name": "Interleukin-36 receptor antagonist protein",
        "gene_name": "IL36RN",
        "organism": "Human",
        "refseq_name": "interleukin-36 receptor antagonist protein",
        "refseq_ac": [
            {
                "id": "NP_036407",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036407",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL36RN; FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; PRO4342",
        "gene_names_refseq": "FIL1(DELTA); FIL1D; FIL1; IL-36Ra; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; IL36RN; PSORP; PSORS14",
        "protein_names_uniprotkb": "Interleukin-36 receptor antagonist protein; FIL1 delta; IL-1 delta; IL-1-related protein 3; IL-1F5; IL-1HY1; IL-1L1; IL-1RP3; IL-1ra homolog 1; IL-36Ra; Interleukin-1 HY1; Interleukin-1 delta; Interleukin-1 family member 5; Interleukin-1 receptor antagonist homolog 1; Interleukin-1-like protein 1",
        "protein_names_refseq": "IL-1 related protein 3; IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta); IL-1ra homolog 1; IL1F5 (Canonical product IL-1F5a); interleukin 1 family, member 5 (delta); interleukin-1 HY1; interleukin-1 receptor antagonist homolog 1; interleukin-1-like protein 1; interleukin-36 receptor antagonist protein",
        "tax_id": 9606,
        "disease": "pustular psoriasis 14 (Disease Ontology:DOID:0080474)",
        "pathway": " (hsa:26525);  (R-HSA-9014826)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10512743;10625660;10860666;11093146;11237011;11466363;11991722;12975309;14734551;21839423;21848462;21965679;22315422;22903787;23147407;25673295;32157095;32272059;32938616;35051231;36577391;36804966;36843152;36843341;37414245",
        "class_list": "",
        "function": "Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia., [RefSeq, PubMed]; Deficiency of interleukin-36 receptor antagonist (DITRA): An analysis of 58 Chinese patients in a tertiary hospital in Taiwan., [RefSeq, PubMed]; Different Clinical Features of Pediatric Generalized Pustular Psoriasis in Patients with or without IL36RN Variants., [RefSeq, PubMed]; Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population., [RefSeq, PubMed]; In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex., [RefSeq, PubMed]; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2I4;Q56AT9;Q7RTZ6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005152 interleukin-1 receptor antagonist activity;GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0032700 negative regulation of interleukin-17 production;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0019732 antifungal humoral response",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9UBH0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22301-1",
        "uniprot_id": [
            {
                "id": "IL10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22301",
                "type": "external"
            }
        ],
        "mass": 20517.0,
        "length": 178,
        "protein_name": "Interleukin-10",
        "gene_name": "IL10",
        "organism": "Human",
        "refseq_name": "interleukin-10 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_000563",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000563",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL10",
        "gene_names_refseq": "CSIF; GVHDS; IL-10; IL10A; IL10; TGIF",
        "protein_names_uniprotkb": "Interleukin-10; CSIF; Cytokine synthesis inhibitory factor; IL-10",
        "protein_names_refseq": "T-cell growth inhibitory factor; cytokine synthesis inhibitory factor; interleukin-10 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); inflammatory bowel disease (Disease Ontology:DOID:0050589); rheumatic heart disease (Disease Ontology:DOID:0050827); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); ocular tuberculosis (Disease Ontology:DOID:0070344); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); dry eye syndrome (Disease Ontology:DOID:10140); bacterial infectious disease (Disease Ontology:DOID:104); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); disseminated intravascular coagulation (Disease Ontology:DOID:11247); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); gestational diabetes (Disease Ontology:DOID:11714); pericardial effusion (Disease Ontology:DOID:118); panuveitis (Disease Ontology:DOID:12030); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); Graves' disease (Disease Ontology:DOID:12361); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); intermediate uveitis (Disease Ontology:DOID:12732); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); carotid stenosis (Disease Ontology:DOID:13001); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); toxic shock syndrome (Disease Ontology:DOID:14115); choroid disease (Disease Ontology:DOID:1417); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); major depressive disorder (Disease Ontology:DOID:1470); aggressive periodontitis (Disease Ontology:DOID:1474); alcohol use disorder (Disease Ontology:DOID:1574); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); mitral valve stenosis (Disease Ontology:DOID:1754); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); severe acute respiratory syndrome (Disease Ontology:DOID:2945); high grade glioma (Disease Ontology:DOID:3070); central nervous system lymphoma (Disease Ontology:DOID:3234); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); liver cancer (Disease Ontology:DOID:3571); toxic encephalopathy (Disease Ontology:DOID:3602); skin disease (Disease Ontology:DOID:37); bronchus carcinoma (Disease Ontology:DOID:3904); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); gallbladder carcinoma (Disease Ontology:DOID:4948); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); thyrotoxicosis (Disease Ontology:DOID:7997); hyperthyroidism (Disease Ontology:DOID:7998); myocarditis (Disease Ontology:DOID:820); periodontitis (Disease Ontology:DOID:824); intestinal obstruction (Disease Ontology:DOID:8437); retinal artery occlusion (Disease Ontology:DOID:8483); lung disease (Disease Ontology:DOID:850); herpes zoster (Disease Ontology:DOID:8536); chronic myeloid leukemia (Disease Ontology:DOID:8552); lip cancer (Disease Ontology:DOID:8564); Hodgkin's lymphoma (Disease Ontology:DOID:8567); ulcerative colitis (Disease Ontology:DOID:8577); vasculitis (Disease Ontology:DOID:865); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); liver benign neoplasm (Disease Ontology:DOID:916); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); postpartum depression (Disease Ontology:DOID:9478); pulmonary eosinophilia (Disease Ontology:DOID:9498); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3586);  (R-HSA-6783783);  (R-HSA-6785807);  (R-HSA-8950505);  (R-HSA-9662834);  (R-HSA-9664323);  (R-HSA-9725370)",
        "pathway_count": 7,
        "publication_count": 308,
        "publication_id_list": "10023775;10066432;10092818;10216106;10219247;10369418;10415057;10433356;10497257;10510379;10556217;10579907;10586089;10601018;10648003;10702393;10706082;10706887;10861086;10867011;10934142;10961890;10975989;11058569;11084045;11104795;11110708;11120780;11237011;11278437;11278729;11280786;11310834;11356008;11404481;11463377;11485736;11504915;11564774;11688984;11751994;11850821;11943732;11960372;11988758;12058067;12112524;12117970;12121653;12185581;12223527;12242343;12417718;12424201;12554859;12600988;12621058;12626585;12750159;12755693;12800156;12825869;12832402;12920229;12934099;1372004;1460289;14623079;14634100;14657427;14712222;14962911;15116091;15161916;15169778;15208656;15261459;15340161;15374880;15479433;15584925;15588951;15805299;15837194;15869882;15879134;15895073;15919823;15950906;16007214;16038020;16048438;16107692;16153455;16161041;16170336;16205632;16236134;16397018;16451196;16510571;16540365;16606674;16825495;16871283;16921024;16939498;16982608;17086210;17353907;17377532;17416736;17427945;17458857;17483340;17572495;17625570;18025162;18070890;18097461;18243101;18353781;18447642;18452557;1847510;18593892;18594010;18644974;18701132;18724359;18818202;18923523;18923524;18923525;19124156;19185846;19397496;1940369;1940799;19456272;19459784;20145033;20188673;20454865;20493732;20807704;21037092;21102457;21134980;21164297;21213368;21252155;21415216;21494621;21596819;21656749;21689689;21730069;21838707;21847362;21937440;21994466;22046235;22205702;22246777;22246778;22249260;22327622;22347464;22383755;22570254;22658521;22693070;22851691;23086340;23104988;23124025;23139213;23172665;23201355;23239810;23455323;23555662;23661334;23675550;23957430;23967200;24060861;24097101;24275664;24338472;24445538;24475247;24496003;24518094;24613930;24736082;24743777;25234944;25342631;25393796;25421750;25795784;25813404;25921060;26001147;26062823;26301689;27245569;27573755;27874193;28404650;28420440;28467828;28659337;28741662;29045841;29455642;29873274;30131584;30304975;30692217;31366041;31986264;32222466;32350084;32576222;33349241;35154160;39336814;39380276;39382416;39394532;7510216;7512027;7512451;7516408;7517665;7522622;7529288;7530449;7543512;7547951;7593617;7594602;7684412;7687627;7795521;7796300;7824924;7898939;7902377;7907877;8063757;8085155;8102388;8120391;8144879;8163946;8186324;8226994;8301137;8340414;8364028;8537680;8590020;8602263;8621622;8633037;8657103;8662928;8663118;8668165;8734788;8742066;8797861;8816495;8862523;8871669;8897595;8910398;8921438;8921966;8946277;9000504;9013879;9013939;9042338;9050880;9162098;9312047;9314552;9354687;9405662;9449724;9520379;9523318;9550426;9651359;9723655;9736340;9794440;9819383;9822675;9836587;9857068;9874564;9918218",
        "class_list": "",
        "function": "Diagnostic utility of sortilin & other biomarkers in the diagnosis of carotid & coronary atherosclerosis in individuals with arterial hypertension., [RefSeq, PubMed]; IL-10 A-Allele as a Biomarker for Periodontitis Severity in Bulgarian Patients. Publication Status: Online-Only, [RefSeq, PubMed]; Immune regulatory cytokine., [UniProtKB, UniProtKB, UniProtKB]; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF (PubMed:11564774, PubMed:1940799, PubMed:7512027). Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Seasonal distribution and correlation between IL-10 and IL-13 gene polymorphism and their expression in scabies-infected patients. Publication Status: Online-Only, [RefSeq, PubMed]; Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen., [RefSeq, PubMed]; The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "prognostic; monitoring; predictive",
        "glycan_count": 0,
        "disease_count": 130,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005141 interleukin-10 receptor binding;GO:0046983 protein dimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0032701 negative regulation of interleukin-18 production;GO:0034465 response to carbon monoxide;GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0060302 negative regulation of cytokine activity",
        "synthesized_glycan_count": 0,
        "hit_score": 30.9,
        "record_id": "P22301-1",
        "record_type": "protein",
        "filter_code": "0111000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13164-1",
        "uniprot_id": [
            {
                "id": "IFM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13164",
                "type": "external"
            }
        ],
        "mass": 13964.0,
        "length": 125,
        "protein_name": "Interferon-induced transmembrane protein 1",
        "gene_name": "IFITM1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IFITM1; CD225; IFI17",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Interferon-induced transmembrane protein 1; DSPA2a; Dispanin subfamily A member 2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "gallbladder adenocarcinoma (Disease Ontology:DOID:3500); adenosquamous gallbladder carcinoma (Disease Ontology:DOID:5627)",
        "pathway": " (hsa:8519);  (R-HSA-198933);  (R-HSA-909733)",
        "pathway_count": 3,
        "publication_count": 213,
        "publication_id_list": "10395669;10499918;10542297;10746781;10982844;11092454;11121542;11237011;11265639;11337497;11377645;11404376;11489943;11513152;11556966;11585831;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12029096;12213321;12483297;12588680;12766484;12842042;1383329;14719373;14769151;14970179;15034010;15047845;15136729;15155468;15187158;15304001;15312780;15449939;15534202;15541655;15580655;15607800;15778442;15778510;15781451;15800062;15851719;15864273;16009940;16014749;16091383;16129954;16171819;16339513;16380601;16551255;16737824;16754721;16847454;16893496;16904340;16928187;16987978;17045824;17057721;17237375;17251292;1730654;17337780;17351669;17969444;18031695;18035202;18037897;18055229;18209062;18234675;18446792;18575461;18593354;18991276;19149696;19359216;19499152;19592130;20064371;20130243;20363976;20643137;20730098;20838853;21166591;21177806;21241660;21253575;21800138;21841309;21877119;21976647;2211721;22363774;22396535;22479637;22634173;23061660;23121362;23186163;23481700;23695528;23929856;2398277;24305946;24417533;2492664;25105503;25371710;25502872;25505266;25576301;25645385;25703557;25716998;26154972;26284469;26300885;26354436;26375851;26992070;27862975;28832583;28904123;29242379;29437277;29493099;29508533;29557506;29786170;30315122;30429286;30485383;31092671;31154438;31611695;31844290;31998317;32032529;32113509;32350084;32357974;32387766;32488085;32502341;32511913;32574262;32661006;32758689;32862111;32897882;32938616;32983136;33051876;33117408;33141586;33189161;33193462;33270927;33298915;33396578;33522642;33537174;33912179;33981976;34078123;34357683;34561969;35051231;35251023;36215666;36284347;36581221;38665916;6162102;6548414;688397;7510216;7526154;7531291;7537377;7540766;7542404;7559564;8178173;8197134;8232552;8605876;8621447;8702790;8995416;9029102;9096384;9121453;9242679;9285412;9314561;9334213;9660177;9700512;9730896;9847332;9861020",
        "class_list": "",
        "function": "IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15322;Q53XZ0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0051607 defense response to virus;GO:0030336 negative regulation of cell migration;GO:0045071 negative regulation of viral genome replication",
        "synthesized_glycan_count": 0,
        "hit_score": 21.6,
        "record_id": "P13164-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15294-1",
        "uniprot_id": [
            {
                "id": "OGT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15294",
                "type": "external"
            }
        ],
        "mass": 116925.0,
        "length": 1046,
        "protein_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit",
        "gene_name": "OGT",
        "organism": "Human",
        "refseq_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1",
        "refseq_ac": [
            {
                "id": "NP_858058",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_858058",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OGT",
        "gene_names_refseq": "HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1; OGT; XLID106",
        "protein_names_uniprotkb": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; 2.4.1.255; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT",
        "protein_names_refseq": "O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase",
        "tax_id": 9606,
        "disease": "non-syndromic X-linked intellectual disability 106 (Disease Ontology:DOID:0080240); aortic valve stenosis (Disease Ontology:DOID:1712); congenital disorder of glycosylation (Disease Ontology:DOID:5212); congestive heart failure (Disease Ontology:DOID:6000); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:8473);  (R-HSA-3214847);  (R-HSA-5213460);  (R-HSA-5675482);  (R-HSA-5689603);  (R-HSA-9772755)",
        "pathway_count": 6,
        "publication_count": 287,
        "publication_id_list": "10786633;10821277;11237011;11773972;12150998;12393701;12482972;12670868;14636557;14992727;15199122;15313887;15327282;15361863;16227571;16239140;16282325;16387653;16829959;16878130;16892064;16906146;17139257;17355966;17500065;17612494;17614351;17644308;17671196;17925232;17998332;18381289;18497827;18570872;18598942;18623064;18669648;18829457;18829459;18838386;18838538;19073609;19103755;19124460;19187761;19187765;19188440;19377461;19451179;19524512;19524513;19556245;19815555;19833729;20018852;20018868;20068231;20200153;20305658;20436459;20575550;20668475;20716525;20805357;20824293;20961854;21106533;21124902;21131905;21135039;21220120;21240259;21285374;21737330;21740066;22121020;22265413;22266653;22327296;22421439;22652693;22665483;22817896;22869377;22923583;23103939;23186163;23222540;23301498;23353889;23395175;23481700;23508102;23629655;23995757;24059293;24244196;24316671;24366607;24368734;24474760;24563466;24680668;24703947;24714562;24715725;24760753;24813885;24995978;2530630;25418920;25505266;25561738;25576301;25593305;25645385;25679214;25852146;25880248;25892735;25996294;26154972;26237509;26273451;26324722;26369908;26374642;26375851;26678539;26758079;26775703;26811146;26854602;26866270;26886794;26900751;26929215;26933192;26992070;27397612;27527864;27543614;27563068;27600516;27687229;27698142;27713473;27760318;27846572;27862975;27920218;28182322;28218747;28228285;28302723;28398509;28446606;28510447;28514659;28584052;28657654;28661484;28742148;28832583;28834231;28904123;29021254;29138278;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29577901;29632046;29632711;29681455;29769320;29769354;29786170;29789417;29883609;29883610;29897600;29930286;29937342;30315122;30379171;30397120;30410026;30429286;30484775;30524438;30699359;30770249;30779550;30833945;31031142;31092671;31138766;31154438;31217245;31222486;31358971;31400120;31485071;31527085;31530632;31544921;31627256;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32269263;32350084;32357974;32387766;32488085;32502341;32561730;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33633747;33657400;33691108;33717175;33912179;33936100;33968037;33981976;34012049;34019948;34074792;34087483;34171305;34211107;34357683;34509645;34561969;34667079;34725712;34932366;34933446;34999730;35033534;35051231;35083852;35138101;35190547;35318648;35439434;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37541260;37938771;37962578;38345749;38665916;38852504;39531497;39894887;40136647;40596516;40914422;9083068;9427644;9528852;9558366;9790970;9880483",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Downregulation of O-GlcNAc transferase activity impairs basal autophagy and late endosome positioning under nutrient-rich conditions in human colon cells., [RefSeq, PubMed]; Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085)., [UniProtKB, PubMed]; O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency., [RefSeq, PubMed]; The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line., [UniProtKB, PubMed]; This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 4,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 3,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 3,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 608,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z3K0;Q8WWM8;Q96CC1;Q9UG57",
        "ec_number_list": [
            {
                "id": "2.4.1.255",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.4.22.61",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0031490 chromatin DNA binding;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process",
        "synthesized_glycan_count": 5,
        "hit_score": 29.6,
        "record_id": "O15294-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100010100001.110.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96DB2-1",
        "uniprot_id": [
            {
                "id": "HDA11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96DB2",
                "type": "external"
            }
        ],
        "mass": 39183.0,
        "length": 347,
        "protein_name": "Histone deacetylase 11",
        "gene_name": "HDAC11",
        "organism": "Human",
        "refseq_name": "histone deacetylase 11 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001129513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129513",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HDAC11",
        "gene_names_refseq": "HD11; HDAC11",
        "protein_names_uniprotkb": "Histone deacetylase 11; 3.5.1.98; HD11",
        "protein_names_refseq": "histone deacetylase 11 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79885);  (R-HSA-2122947);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-350054);  (R-HSA-9976102)",
        "pathway_count": 6,
        "publication_count": 86,
        "publication_id_list": "10206645;10713164;10879540;10882063;10964718;11006133;11044625;11112321;11237011;11461910;11585921;11740940;11948178;12050117;12209127;12354787;12374742;12391150;12530964;14980219;15107403;15546612;15574878;15760269;15824097;15829515;16093323;16142391;16256737;16530044;16530045;16738328;16751179;17003037;17114293;17157496;17201809;17401372;17646408;17646409;18043734;18077452;18094723;18296446;18374649;18824583;18824585;19151708;19524514;19726682;20972443;25576301;25645385;28904123;29393594;31844290;32157095;32387766;32897882;32938616;33537174;33912179;33968037;33981976;34087483;34405274;34509645;35051231;36010968;36087429;37659201;38366363;38939938;7566092;7588063;8001118;8649374;8687460;9244301;9315665;9462510;9604939;9620803;9651681;9694793;9819428",
        "class_list": "",
        "function": "Cloning and functional characterization, [RefSeq, PubMed]; Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer., [RefSeq, PubMed]; HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs., [RefSeq, PubMed]; HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3., [RefSeq, PubMed]; HDAC11: A novel target for improved cancer therapy. Review article, [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours, [RefSeq, PubMed]; This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]., [RefSeq]; [Progress on the involvement of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DDK1;Q9H6I7;Q9H6X3;Q9NTC9",
        "ec_number_list": [
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.98",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.57",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57",
                "type": "external"
            },
            {
                "id": "3.5.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48",
                "type": "external"
            },
            {
                "id": "3.5.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004407 histone deacetylase activity;GO:0140297 DNA-binding transcription factor binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0016787 hydrolase activity;GO:0033558 protein lysine deacetylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0000118 histone deacetylase complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0040029 epigenetic regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q96DB2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4G0P3-1",
        "uniprot_id": [
            {
                "id": "HYDIN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4G0P3",
                "type": "external"
            }
        ],
        "mass": 575892.0,
        "length": 5121,
        "protein_name": "Axonemal central pair apparatus protein HYDIN",
        "gene_name": "HYDIN",
        "organism": "Human",
        "refseq_name": "hydrocephalus-inducing protein homolog isoform c",
        "refseq_ac": [
            {
                "id": "NP_001185471",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185471",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HYDIN; HYDIN1; KIAA1864",
        "gene_names_refseq": "CILD5; HYDIN1; HYDIN; PPP1R31",
        "protein_names_uniprotkb": "Axonemal central pair apparatus protein HYDIN; Hydrocephalus-inducing protein homolog",
        "protein_names_refseq": "hydrocephalus-inducing protein homolog isoform c; hydrocephalus-inducing protein homolog; protein phosphatase 1, regulatory subunit 31",
        "tax_id": 9606,
        "disease": "primary ciliary dyskinesia 5 (Disease Ontology:DOID:0110617); hydrocephalus (Disease Ontology:DOID:10908)",
        "pathway": " (hsa:54768)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;16938426;17296793;23022101;23481700;25186273;25576301;28218747;28228285;29557506;30379171;31092671;31429579;31545650;31844290;32387766;32502341;32938616;33633747;34087483;34171305;34509645;35051231;35494241;35580925;36010968;36112114;36140829;36215666;36742411;38253038;38581027;39894887",
        "class_list": "",
        "function": "Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China. Publication Status: Online-Only, [RefSeq, PubMed]; Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries. Publication Status: Online-Only, [RefSeq, PubMed]; HYDIN Variants Are a Common Cause of Primary Ciliary Dyskinesia in French Canadians., [RefSeq, PubMed]; Novel HYDIN variants associated with male infertility in two Chinese families. Publication Status: Online-Only, [RefSeq, PubMed]; Required for ciliary motility (By similarity). Required for localization of SPEF2 to the ciliary axoneme in ciliated respiratory epithelial cells (PubMed:31545650)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]., [RefSeq]; We have found that the human HYDIN locus has been very recently duplicated, with a nearly identical 360-kb paralogous segment inserted on chromosome 1q21.1, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 144,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NC70;A6NLZ0;B4DQY4;B4DRN4;F5H6V3;Q8N3H8;Q8N3P6;Q8TC08;Q96JG3;Q96SS4;Q9H5U3;Q9H9B8;Q9NTI0;Q9UBE5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:1990718 axonemal central pair projection",
        "go_biological_process": "GO:1904158 axonemal central apparatus assembly;GO:0003341 cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q4G0P3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.000100.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYW1-1",
        "uniprot_id": [
            {
                "id": "GTR11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYW1",
                "type": "external"
            }
        ],
        "mass": 53703.0,
        "length": 496,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 11",
        "gene_name": "SLC2A11",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 11 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001020109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020109",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC2A11; GLUT11",
        "gene_names_refseq": "GLUT10; GLUT11; SLC2A11",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 11; GLUT-11; Glucose transporter type 11",
        "protein_names_refseq": "facilitative glucose transporter GLUT11; glucose transporter protein 10; glucose transporter protein 11; glucose transporter type 10; glucose transporter type 11; glucose transporter-like protein XI; solute carrier family 2 (facilitated glucose transporter), member 11; solute carrier family 2, facilitated glucose transporter member 11 isoform c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:66035);  (R-HSA-189200)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10821868;10860667;10970791;10987651;11133510;11237011;11245466;11247674;11425315;11583593;11681785;11741323;11780755;11832379;11994746;12175779;12504846;12590146;12885248;1415574;14614622;14739288;14997204;15033637;15607332;15902306;16154905;16303743;16550171;17050778;1756912;17635959;17710649;18063724;18327257;18477386;1918382;20616166;21107422;21940664;22212718;22452979;22521588;2656669;26650681;28904123;29557506;35051231;8457197;9354798;9751501",
        "class_list": "glycogene",
        "function": "A novel sugar transporter that is alternatively spliced in various tissues, [RefSeq, PubMed]; Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer., [RefSeq, PubMed]; Different promoters and splicing generate three SLC2A11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics., [RefSeq, PubMed]; Facilitative glucose transporter., [UniProtKB, PubMed]; GLUT11 can also transport fructose, but it has the motif DSV at the same position, which appears to function in the same manner as NXI and when all three residues are replaced with NAV fructose transport lost., [RefSeq, PubMed]; This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 593,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PH55;Q542Y4;Q6ICJ5;Q8WXF9;Q8WYM4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051119 sugar transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015149 hexose transmembrane transporter activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0042383 sarcolemma",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport;GO:0008645 hexose transmembrane transport;GO:1990539 fructose import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q9BYW1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4L1-1",
        "uniprot_id": [
            {
                "id": "HYOU1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4L1",
                "type": "external"
            }
        ],
        "mass": 111335.0,
        "length": 999,
        "protein_name": "Hypoxia up-regulated protein 1",
        "gene_name": "HYOU1",
        "organism": "Human",
        "refseq_name": "hypoxia up-regulated protein 1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001124463",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124463",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HYOU1; GRP170; HSPH4; ORP150",
        "gene_names_refseq": "GRP-170; Grp170; HSP12A; HYOU1; IMD59; ORP-150; ORP150",
        "protein_names_uniprotkb": "Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; 170 kDa glucose-regulated protein; GRP-170; Heat shock protein family H member 4; ORP-150",
        "protein_names_refseq": "150 kDa oxygen-regulated protein; 170 kDa glucose-regulated protein; epididymis secretory sperm binding protein; heat shock protein family H member 4; hypoxia up-regulated protein 1 isoform 1 precursor; hypoxia up-regulated protein 1; oxygen regulated protein (150kD)",
        "tax_id": 9606,
        "disease": "immunodeficiency 59 (Disease Ontology:DOID:0111974)",
        "pathway": " (hsa:10525);  (R-HSA-3000484);  (R-HSA-381038);  (R-HSA-9918432)",
        "pathway_count": 4,
        "publication_count": 162,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10037731;10228156;10601334;10827079;10965054;11237011;12204115;12475965;12754519;15371419;15466936;16263699;16335952;16461360;16539657;17131193;17615582;18078691;18452278;18663603;18664523;19159218;19237602;19349973;19696406;20068231;20686127;21282569;21526146;21654843;22661428;23090970;23584533;24190977;24275569;24366607;24397554;24715725;25418920;25502872;25813380;26154972;26208004;26768311;26992070;27090790;27383988;27452731;27846572;27913302;27920218;28063628;28228285;28228593;28467828;28514659;28832583;28834231;28904123;29242379;29249144;29314611;29391424;29393594;29493099;29508533;29557506;29632046;29671580;29741879;29786170;30059200;30315122;30397120;30410026;30429286;30444036;30459171;30573663;30620550;31020640;31154438;31217245;31530632;31611695;31844290;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33214551;33298915;33465208;33537174;33592498;33717175;33792181;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34089345;34171305;34229054;34357683;34433824;34509645;34704918;34725712;34932366;35008409;35051231;35132862;35138101;35154160;35215835;35251023;35254053;35318648;35580925;35705054;35822684;36010968;36215666;36241641;36348197;37074911;37217939;37541260;37938771;38665916;38793607;39531497;39534244;40307207;40596516;40914422;7590364;8666242;9020069;9037597;9395444;9450183;9473480",
        "class_list": "",
        "function": "HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA., [RefSeq, PubMed]; HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer. Erratum:[Mol Biol Rep. 2023 Jun;50(6):5527. doi: 10.1007/s11033-023-08325-4. PMID: 37072656], [RefSeq, PubMed]; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Long non-coding RNA KCNQ1OT1 facilitates the progression of cervical cancer and tumor growth through modulating miR-296-5p/HYOU1 axis., [RefSeq, PubMed]; The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 11,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 9,
        "reported_o_glycosites_with_glycan": 21,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 11,
        "total_reported_o_glycosites": 21,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 11,
        "total_o_glycosites": 21,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 145,
        "disease_count": 1,
        "glyco_site_count": 32,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8C1Z0;B7Z909;Q2I204;Q53H25",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0002931 response to ischemia;GO:0071456 cellular response to hypoxia;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0034976 response to endoplasmic reticulum stress;GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 34.0,
        "record_id": "Q9Y4L1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y450-1",
        "uniprot_id": [
            {
                "id": "HBS1L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y450",
                "type": "external"
            }
        ],
        "mass": 75473.0,
        "length": 684,
        "protein_name": "HBS1-like protein",
        "gene_name": "HBS1L",
        "organism": "Human",
        "refseq_name": "HBS1-like protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001138630",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138630",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBS1L; HBS1; KIAA1038",
        "gene_names_refseq": "EF-1a; ERFS; HBS1L; HBS1; HSPC276; eRF3c",
        "protein_names_uniprotkb": "HBS1-like protein; 3.6.5.-; ERFS",
        "protein_names_refseq": "ERF3-similar protein; HBS1-like protein isoform 2; HBS1-like protein; Hsp70 subfamily B suppressor 1-like protein; eRF3 family member",
        "tax_id": 9606,
        "disease": "beta thalassemia (Disease Ontology:DOID:12241)",
        "pathway": " (hsa:10767);  (R-HSA-429958)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "11237011;11283721;14749774;15068804;15231747;15273322;15475613;15592455;15769464;16141059;17174896;17245413;17545563;17592125;17712044;18441014;18667698;18669648;19060886;19225159;19239894;19651622;20068231;21448132;22424782;22645359;23186163;23223233;23481700;23667253;24288412;24366607;24715725;25576301;26154972;26992070;27846572;27863242;27920218;28204585;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;30379171;30410026;30429286;30524438;30707697;31217245;31530632;31637018;31844290;31848261;32006463;32157095;32350084;32357974;32387766;32447424;32502341;32897882;32938616;33141586;33298915;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34099068;34171305;34211107;34357683;34509645;34561969;35051231;35251023;35254053;35561310;35580925;36010968;36241641;36284347;36888630;40307207;9872408",
        "class_list": "",
        "function": "GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; HBS1L-related genetic variants play a key role in control of fetal hemoglobin levels., [RefSeq, PubMed]; Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in beta0-thalassemia/HbE erythroid cells. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Patients carrying Fetal Hemoglobin-boosting alleles of BCL11A and HMIP-2 ( (HBS1L-MYB) were associated with milder clinical phenotypes. Higher HbF concentration may underlie this effect., [RefSeq, PubMed]; The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts., [RefSeq, PubMed]; This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z365;Q4VX89;Q4VX90;Q5T7G3;Q8NDW9;Q9UPW3",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0022626 cytosolic ribosome;GO:1990533 Dom34-Hbs1 complex",
        "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006417 regulation of translation;GO:0007165 signal transduction;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9Y450-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NMS7-1",
        "uniprot_id": [
            {
                "id": "L37A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NMS7",
                "type": "external"
            }
        ],
        "mass": 188258.0,
        "length": 1700,
        "protein_name": "Leucine-rich repeat-containing protein 37A",
        "gene_name": "LRRC37A",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 37A precursor",
        "refseq_ac": [
            {
                "id": "NP_055649",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055649",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC37A; LRRC37A1",
        "gene_names_refseq": "LRRC37A1; LRRC37A; LRRC37",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 37A",
        "protein_names_refseq": "leucine-rich repeat-containing protein 37A precursor; leucine-rich repeat-containing protein 37A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9884)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;22706990;30779550;34357683",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68DY2;Q8IWC7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "A6NMS7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15011-1",
        "uniprot_id": [
            {
                "id": "HERP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15011",
                "type": "external"
            }
        ],
        "mass": 43720.0,
        "length": 391,
        "protein_name": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein",
        "gene_name": "HERPUD1",
        "organism": "Human",
        "refseq_name": "homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001010989",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010989",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HERPUD1; HERP; KIAA0025; MIF1",
        "gene_names_refseq": "HERPUD1-IT1; HERPUD1; HERP; Mif1; SUP",
        "protein_names_uniprotkb": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Methyl methanesulfonate (MMF)-inducible fragment protein 1",
        "protein_names_refseq": "HERPUD1 intronic transcript 1; MMS-inducible; homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; methyl methanesulfonate (MMF)-inducible fragment protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9709);  (R-HSA-380994)",
        "pathway_count": 2,
        "publication_count": 107,
        "publication_id_list": "10708769;10922362;10958673;11112790;11237011;11799129;12153396;14742429;14978097;15385533;16289116;16687408;16912112;16931790;16940180;16989641;18285520;18307982;18656546;18840095;20022965;20361218;21535081;22424782;22544926;22802018;22819556;22978410;23269699;23481700;24275569;24715725;25418920;25576301;25645385;26154972;26375851;2663993;2664463;26992070;27397612;27600516;27846572;28218747;28228285;28514659;28827405;28832583;28860189;28904123;29242379;29413899;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30410026;30524438;31844290;32157095;32357974;32387766;32488085;32488540;32502341;3260265;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34353909;34405274;34433824;34509645;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36215666;36220983;36241641;36284347;36544104;36746840;37938771",
        "class_list": "",
        "function": "Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort., [RefSeq, PubMed]; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982)., [UniProtKB, PubMed, PubMed, PubMed]; Enhances presnilin-mediated generation of amyloid beta protein, [RefSeq, PubMed]; HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification., [RefSeq, PubMed]; Herpud1 deficiency could reduce amyloid-beta40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway., [RefSeq, PubMed]; The Brucella effector BspL targets the ER-associated degradation (ERAD) pathway and delays bacterial egress from infected cells., [RefSeq, PubMed]; The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]., [RefSeq]; Upregulation by Wnt-1, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PGD1;O60644;Q6IAN8;Q96D92",
        "ec_number_list": [],
        "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:1990037 Lewy body core",
        "go_biological_process": "GO:1904292 regulation of ERAD pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q15011-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5Z4-1",
        "uniprot_id": [
            {
                "id": "HEBP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5Z4",
                "type": "external"
            }
        ],
        "mass": 22875.0,
        "length": 205,
        "protein_name": "Heme-binding protein 2",
        "gene_name": "HEBP2",
        "organism": "Human",
        "refseq_name": "heme-binding protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_055135",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055135",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEBP2; C6orf34; SOUL",
        "gene_names_refseq": "C6ORF34B; C6orf34; HEBP2; PP23; SOUL",
        "protein_names_uniprotkb": "Heme-binding protein 2; PP23; Placental protein 23; Protein SOUL",
        "protein_names_refseq": "heme-binding protein 2 isoform 2; placental protein 23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23593);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "10640688;11237011;11827465;17098234;19413330;19415658;19664994;19690332;2018407;21639858;22223895;23186163;23650620;27784779;28004381;38253038;8692836",
        "class_list": "",
        "function": "Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions., [UniProtKB, PubMed]; SOUL promotes necrotic cell death by inducing mitochondrial permeability transition, [RefSeq, PubMed]; The gene copy numbers and mRNA levels for both ALG-2 and HEBP2 are significantly upregulated in breast and lung cancer. Coexpression of ALG-2 and HEBP2 markedly increases the cytoplasmic pool of ALG-2 and alters the subcellular distribution of HEBP2. Abnormalities in the ALG-2/HEBP2 interaction impairs spindle orientation and positioning during mitosis., [RefSeq, PubMed]; The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96P57",
        "ec_number_list": [],
        "go_molecular_function": "GO:0020037 heme binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q9Y5Z4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NVX0-1",
        "uniprot_id": [
            {
                "id": "HAUS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NVX0",
                "type": "external"
            }
        ],
        "mass": 26933.0,
        "length": 235,
        "protein_name": "HAUS augmin-like complex subunit 2",
        "gene_name": "HAUS2",
        "organism": "Human",
        "refseq_name": "HAUS augmin-like complex subunit 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001123919",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123919",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAUS2; C15orf25; CEP27",
        "gene_names_refseq": "C15orf25; CEP27; HAUS2; HsT17025",
        "protein_names_uniprotkb": "HAUS augmin-like complex subunit 2; Centrosomal protein of 27 kDa; Cep27",
        "protein_names_refseq": "HAUS augmin-like complex subunit 2 isoform 2; centrosomal protein 27kDa; centrosomal protein of 27 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55142);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 8,
        "publication_count": 113,
        "publication_id_list": "11076968;11237011;11956313;12207013;12221128;12364337;12852856;13678582;14580337;14654843;15498487;15705883;16357211;16462731;16890155;17574030;17646400;17719545;18037885;18378770;18477460;18521620;18566290;18615013;18694559;18801063;19004860;19081074;19369198;19427217;19940019;20230748;20308558;20399632;20558667;21273506;21347367;21422230;21548880;21565611;21620453;21725307;21792235;22094468;22179047;22365832;22433857;22641346;22653444;23141531;23141541;23253480;23348840;23400999;23481700;23530209;23747070;23769972;23789104;23921553;24053599;24089205;24231678;24469809;24982133;25047611;25313408;25505266;25532896;25576301;25892735;26811146;26992070;28832583;28904123;29242379;29557506;29632711;29786170;30315122;30429286;30484775;30723163;30833945;31092671;31154438;31844290;31848261;32157095;32265295;32488085;32502341;32938616;32983136;33141586;33298915;33402344;33912179;33936100;34171305;34357683;34561969;34932366;35051231;35580925;36010968;36241641;38253038;39894887;40596516;7769006;7790358;8838651",
        "class_list": "",
        "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JH36;Q9H9B3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule",
        "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0007098 centrosome cycle;GO:0051225 spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q9NVX0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95965-1",
        "uniprot_id": [
            {
                "id": "ITGBL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95965",
                "type": "external"
            }
        ],
        "mass": 53921.0,
        "length": 494,
        "protein_name": "Integrin beta-like protein 1",
        "gene_name": "ITGBL1",
        "organism": "Human",
        "refseq_name": "integrin beta-like protein 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001258684",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258684",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ITGBL1; OSCP; TIED",
        "gene_names_refseq": "ITGBL1; OSCP; TIED",
        "protein_names_uniprotkb": "Integrin beta-like protein 1; Osteoblast-specific cysteine-rich protein; Ten integrin EGF-like repeat domain-containing protein",
        "protein_names_refseq": "integrin beta like 1; integrin beta-like protein 1 isoform 2 precursor; integrin, beta-like 1 (with EGF-like repeat domains); osteoblast-specific cysteine-rich protein; ten integrin EGF-like repeat domain-containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9358);  (R-HSA-8941332)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "10051402;11237011;12364586;23090970;23389849;24190977;26060017;27317874;30429286;31848261;34409913;35066808;35584452;35596183;38332530",
        "class_list": "",
        "function": "A comprehensive analysis of potential gastric cancer prognostic biomarker ITGBL1 associated with immune infiltration and epithelial-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; ITGBL1 promotes anoikis resistance and metastasis in human gastric cancer via the AKT/FBLN2 axis., [RefSeq, PubMed]; ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin beta-like 1 protein (ITGBL1) promotes cell migration by preferentially inhibiting integrin-ECM binding at the trailing edge., [RefSeq, PubMed]; Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis., [RefSeq, PubMed]; This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5M5;B3KTP1;B4DQ02;Q8N172;Q9NPR0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "O95965-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q09FC8-1",
        "uniprot_id": [
            {
                "id": "ZN415_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q09FC8",
                "type": "external"
            }
        ],
        "mass": 68798.0,
        "length": 603,
        "protein_name": "Zinc finger protein 415",
        "gene_name": "ZNF415",
        "organism": "Human",
        "refseq_name": "zinc finger protein 415 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001129510",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129510",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF415",
        "gene_names_refseq": "Pact; ZNF415; ZfLp",
        "protein_names_uniprotkb": "Zinc finger protein 415",
        "protein_names_refseq": "zinc finger protein 415 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55786);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;17055453;2163759;22863851;29557506;33968037;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53., [UniProtKB, PubMed]; ZNF415 isoforms in COS-7 cells inhibits the transcriptional activities of AP-1 and p53, suggesting that the ZNF415 protein may be involved in AP-1- and p53-mediated transcriptional activity., [RefSeq, PubMed]; ZfLp is a zinc finger protein that functions as a drug carrier protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H287;Q09FC7;Q09FC9;Q09FD0;Q6NSZ2;Q6P3S0;Q9NUR2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q09FC8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZ01-1",
        "uniprot_id": [
            {
                "id": "TECR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZ01",
                "type": "external"
            }
        ],
        "mass": 36034.0,
        "length": 308,
        "protein_name": "Very-long-chain enoyl-CoA reductase",
        "gene_name": "TECR",
        "organism": "Human",
        "refseq_name": "very-long-chain enoyl-CoA reductase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001308099",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308099",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TECR; GPSN2; SC2",
        "gene_names_refseq": "GPSN2; MRT14; SC2; TECR; TER",
        "protein_names_uniprotkb": "Very-long-chain enoyl-CoA reductase; 1.3.1.93; Synaptic glycoprotein SC2; TER; Trans-2,3-enoyl-CoA reductase",
        "protein_names_refseq": "epididymis secretory sperm binding protein; glycoprotein, synaptic 2; synaptic glycoprotein SC2; very-long-chain enoyl-CoA reductase isoform 2; very-long-chain enoyl-CoA reductase",
        "tax_id": 9606,
        "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); autosomal recessive intellectual developmental disorder 14 (Disease Ontology:DOID:0081188)",
        "pathway": " (hsa:9524);  (R-HSA-75876)",
        "pathway_count": 2,
        "publication_count": 96,
        "publication_id_list": "10548543;10954726;11237011;11889465;12371743;12482854;12525535;12975357;15469937;15847654;16036915;16371355;17379924;17681178;17762044;18003621;18554506;18728184;19505953;19608861;19826053;20068231;20112406;20937905;21212097;21959040;24220030;24366607;24715725;25049234;25418920;25576301;25645385;25892735;26154972;26375851;26811146;26929215;26992070;27452731;27600516;27846572;27920218;28063628;28218747;28228285;28510447;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;29786170;29789417;30315122;30410026;30484775;30524438;31020640;31217245;31844290;32119511;32157095;32357974;32387766;32897882;32938616;32983136;33298915;33592498;33633747;33717175;33912179;33936100;33968037;34171305;34357683;34932366;35051231;35083852;35561310;35580925;36010968;36284347;37938771;38224948;38422897;38665916;8075637;9653160",
        "class_list": "",
        "function": "Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases., [RefSeq, PubMed]; Data indicate that trans-2-enoyl-CoA reductase TER is involved in both very long-chain fatty acids (VLCFAs) synthesis and sphingosine degradation within sphingolipids., [RefSeq, PubMed]; Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13., [RefSeq, PubMed]; Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Observational study of genetic testing. (HuGE Navigator) Erratum:[Transfusion. 2005 Jun;45(6):1045], [RefSeq, PubMed]; The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation., [RefSeq, PubMed]; This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD55;O75350;Q6IBB2;Q9BWK3;Q9Y6P0",
        "ec_number_list": [
            {
                "id": "1.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-",
                "type": "external"
            },
            {
                "id": "1.3.1.93",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.93",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity;GO:0102758 very-long-chain enoyl-CoA reductase activity;GO:0016491 oxidoreductase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q9NZ01-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99665-1",
        "uniprot_id": [
            {
                "id": "I12R2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99665",
                "type": "external"
            }
        ],
        "mass": 97135.0,
        "length": 862,
        "protein_name": "Interleukin-12 receptor subunit beta-2",
        "gene_name": "IL12RB2",
        "organism": "Human",
        "refseq_name": "interleukin-12 receptor subunit beta-2 isoform d precursor",
        "refseq_ac": [
            {
                "id": "NP_001245145",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245145",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL12RB2",
        "gene_names_refseq": "IL12RB2",
        "protein_names_uniprotkb": "Interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2",
        "protein_names_refseq": "IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; interleukin-12 receptor subunit beta-2 isoform d precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3595);  (R-HSA-8984722);  (R-HSA-9020591);  (R-HSA-9942503)",
        "pathway_count": 4,
        "publication_count": 56,
        "publication_id_list": "10.1101/2023.09.13.557529;10198225;10415122;10600539;10663559;10899108;11054122;11237011;12121660;12829785;12893768;1347984;14559241;15004198;15087447;15720785;1578138;16324152;1674604;17874423;18033300;18389480;20054003;20058876;22306691;22487722;22814351;24058793;24572363;24743305;25259790;26279360;26972013;27920218;31092671;31154438;31324691;31844290;31848261;32157095;32387766;33287915;34531288;35051231;35494241;35580925;35923356;36328955;7527811;7638186;7911493;8943050;9120388;9342359;9498755;9890938",
        "class_list": "",
        "function": "Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients., [RefSeq, PubMed]; Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production., [UniProtKB]; Role of Genetic Polymorphisms in IL12Rbeta2 in Chronic Obstructive Pulmonary Disease. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AN98;B7ZKL9;F5H7L6;Q2M3V3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015026 coreceptor activity;GO:0019901 protein kinase binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0035722 interleukin-12-mediated signaling pathway;GO:0032729 positive regulation of type II interferon production;GO:0030888 regulation of B cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q99665-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UM44-1",
        "uniprot_id": [
            {
                "id": "HHLA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UM44",
                "type": "external"
            }
        ],
        "mass": 46850.0,
        "length": 414,
        "protein_name": "HERV-H LTR-associating protein 2",
        "gene_name": "HHLA2",
        "organism": "Human",
        "refseq_name": "HERV-H LTR-associating protein 2 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001269485",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269485",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HHLA2",
        "gene_names_refseq": "B7-H5; B7-H7; B7H7; B7y; HHLA2",
        "protein_names_uniprotkb": "HERV-H LTR-associating protein 2; Human endogenous retrovirus-H long terminal repeat-associating protein 2",
        "protein_names_refseq": "HERV-H LTR-associating 2; HERV-H LTR-associating protein 2 isoform a precursor; HERV-H LTR-associating protein 2; human endogenous retrovirus-H long terminal repeat-associating protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11148)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10444326;11237011;23271734;23716685;23784006;25519928;25549724;26992070;29331515;29557506;29789417;32938616;34185709;35051231;35494241;35580925;37891555;38321252;38578157;38762741",
        "class_list": "",
        "function": "B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H, [RefSeq, PubMed]; Data indicate that HHLA2 protein was predominantly found on cell membranes with some in the cytoplasm., [RefSeq, PubMed]; HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway. Publication Status: Online-Only, [RefSeq, PubMed]; HHLA2 is more significantly associated with poor prognosis in TSCC than PD-L1., [RefSeq, PubMed]; HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway., [RefSeq, PubMed]; Low B7-H5 expression is associated with pancreatic adenocarcinomas., [RefSeq, PubMed]; Regulation of HHLA2 expression in kidney cancer and myeloid cells. Publication Status: Online-Only, [RefSeq, PubMed]; The HHLA2 pathway represents a novel immunosuppressive mechanism within the tumor microenvironment., [RefSeq, PubMed]; This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]; Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade., [UniProtKB, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKN2;D3DN60;Q9NWQ6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0031295 T cell costimulation;GO:0050852 T cell receptor signaling pathway;GO:0001819 positive regulation of cytokine production;GO:0001817 regulation of cytokine production;GO:0042104 positive regulation of activated T cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q9UM44-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00178-1",
        "uniprot_id": [
            {
                "id": "GTPB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00178",
                "type": "external"
            }
        ],
        "mass": 72454.0,
        "length": 669,
        "protein_name": "GTP-binding protein 1",
        "gene_name": "GTPBP1",
        "organism": "Human",
        "refseq_name": "GTP-binding protein 1",
        "refseq_ac": [
            {
                "id": "NP_004277",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004277",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTPBP1",
        "gene_names_refseq": "GP-1; GP1; GTPBP1; HSPC018; NEDFET1",
        "protein_names_uniprotkb": "GTP-binding protein 1; 3.6.5.3; G protein 1; GP-1; GP1",
        "protein_names_refseq": "G-protein 1; GTP-binding protein 1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with characteristic facial and ectodermal features and tetraparesis 1 (MONDO:MONDO:0975745)",
        "pathway": " (hsa:9567)",
        "pathway_count": 1,
        "publication_count": 68,
        "publication_id_list": "11237011;17081983;18477386;18669648;19413330;19415658;19651622;19664995;19690332;20058876;20068231;20230923;21406692;23186163;23301498;23481700;24715725;25418920;25502872;25505266;25576301;26598643;26992070;27600516;27846572;27920218;28228285;28832583;28834231;28904123;29242379;29314611;29393594;29557506;29632046;29786170;30108131;30429286;30524438;31020640;31154438;31373491;31844290;32119511;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33912179;33968037;33981976;34171305;34357683;34509645;34932366;35051231;35154160;35580925;36010968;36215666;36241641;38118446;38665916;40914422;9070279",
        "class_list": "",
        "function": "Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome., [RefSeq, PubMed]; GTPBP1 possesses eEF1A-like elongation activity, delivering cognate aminoacyl-transfer RNA to the ribosomal A site in a GTP-dependent manner. It also stimulates exosomal degradation of mRNAs in elongation complexes., [RefSeq, PubMed]; GTPase that plays a role in the elongation phase of protein synthesis by forming ternary complexes with GTP and aminoacyl-transfer RNAs (aa-tRNAs), and delivering aa-tRNAs to the ribosomal A site in a GTP-dependent manner (PubMed:30108131). Is also able to deliver deacylated tRNA to the A site (PubMed:30108131). Additionally, it is involved in RNA quality control; after GTP hydrolysis, which is not immediately followed by rapid peptide bond formation, GTPBP1 likely retains aa-tRNA in the A site and promotes exosomal degradation of faulty mRNAs engaged in 80S elongation complexes (PubMed:30108131). Plays a role in the regulation of circadian mRNA stability (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IC67",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0003746 translation elongation factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0000177 cytoplasmic exosome (RNase complex)",
        "go_biological_process": "GO:0071025 RNA surveillance;GO:0006955 immune response;GO:0007165 signal transduction;GO:0046039 GTP metabolic process;GO:0061014 positive regulation of mRNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "O00178-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3LXA3-1",
        "uniprot_id": [
            {
                "id": "TKFC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3LXA3",
                "type": "external"
            }
        ],
        "mass": 58947.0,
        "length": 575,
        "protein_name": "Triokinase/FMN cyclase",
        "gene_name": "TKFC",
        "organism": "Human",
        "refseq_name": "triokinase/FMN cyclase isoform b",
        "refseq_ac": [
            {
                "id": "NP_056348",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056348",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TKFC; DAK",
        "gene_names_refseq": "DAK; NET45; TKFCD; TKFC",
        "protein_names_uniprotkb": "Triokinase/FMN cyclase; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); FAD-AMP lyase (cyclic FMN forming); FMN cyclase; Glycerone kinase; Triokinase; Triose kinase",
        "protein_names_refseq": "ATP-dependent dihydroxyacetone kinase; DHA kinase; Dha kinase/FMN cyclase; FAD-AMP lyase cyclic FMN forming; FAD-AMP lyase cyclizing; bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); dihydroxyacetone kinase 2 homolog; glycerone kinase; testis tissue sperm-binding protein Li 84P; triokinase/FMN cyclase isoform b; triokinase/FMN cyclase",
        "tax_id": 9606,
        "disease": "triokinase and FMN cyclase deficiency syndrome (MONDO:MONDO:0032927)",
        "pathway": " (hsa:26007);  (R-HSA-168928);  (R-HSA-70350);  (R-HSA-9692916);  (R-HSA-9705671)",
        "pathway_count": 5,
        "publication_count": 168,
        "publication_id_list": "11237011;11679716;12019269;12692549;12759408;12941785;13093749;15208624;16125763;16127453;16153868;16266770;16289032;16394098;16753811;17035307;17270291;17392790;17412287;17596301;17600090;17761676;18307765;18591409;19017631;19237742;19380580;19398035;19484123;19531363;20068231;20166139;20403326;20628368;20841500;20949620;22046132;22098443;22253733;22312431;22371574;22941947;23444097;23481700;23483519;24275569;24289155;24509444;24569995;24622840;24715725;24755855;24854014;25135833;2537226;25576301;25645385;25764917;25880248;25907116;26320399;26378163;26992070;27164085;27203180;28148787;28228285;28649982;28832583;28834231;28904123;29242379;29294448;29331515;29557506;29789417;30185776;30315122;30397120;31034780;31231549;31844290;31850239;32004446;32157095;32350084;32353859;32387766;32428392;32488085;32502341;32589897;32726803;32728199;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33141586;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33691108;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33968037;33989516;33990585;34021074;34054808;34084167;34087483;34110168;34166398;34171305;34211107;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35154160;35251023;35561310;35580925;35643212;36010968;36215666;36241641;37051252;37217939;39456221;39894887;4688871;5353106;5777313;7833921;805723;8535439;9610797;9989503",
        "class_list": "",
        "function": "Alternative Splicing of the Last TKFC Intron Yields Transcripts Differentially Expressed in Human Tissues That Code In Vitro for a Protein Devoid of Triokinase and FMN Cyclase Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of human triokinase/FMN cyclase reveals that kinase activity requires intact homodimers, but cyclase requires only a truncated, single domain subunit, [RefSeq, PubMed]; Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease., [RefSeq, PubMed]; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; DAK, the physiological suppressor of cytoplasmic viral RNA sensor MDA5, specifically inhibits MDA5- but not RNA helicase RIG-I-mediated innate antiviral signaling., [RefSeq, PubMed]; Evidence supports that a single protein sustains both FMN cyclase and ATP-dependent Dha kinase activities, probably in a single active center, [RefSeq, PubMed]; The peptide fragment (m/z 520.3) of DAK is a promising biomarker to guide timing of antiviral treatment and to avoid liver biopsy in compensated chronic hepatitis B patients. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2L9C1;Q53EQ9;Q9BVA7;Q9H895",
        "ec_number_list": [
            {
                "id": "2.7.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.28",
                "type": "external"
            },
            {
                "id": "2.7.1.29",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.29",
                "type": "external"
            },
            {
                "id": "4.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004371 glycerone kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0034012 FAD-AMP lyase (cyclizing) activity;GO:0050354 triokinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0005975 carbohydrate metabolic process;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0039534 negative regulation of MDA-5 signaling pathway;GO:0045088 regulation of innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 17.1,
        "record_id": "Q3LXA3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IVT5-1",
        "uniprot_id": [
            {
                "id": "KSR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IVT5",
                "type": "external"
            }
        ],
        "mass": 102160.0,
        "length": 923,
        "protein_name": "Kinase suppressor of Ras 1",
        "gene_name": "KSR1",
        "organism": "Human",
        "refseq_name": "kinase suppressor of Ras 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055053",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055053",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KSR1; KSR",
        "gene_names_refseq": "KSR1; KSR; RSU2",
        "protein_names_uniprotkb": "Kinase suppressor of Ras 1; 2.7.11.1",
        "protein_names_refseq": "kinase suppressor of Ras 1 isoform 1",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612); breast adenocarcinoma (Disease Ontology:DOID:3458)",
        "pathway": " (hsa:8844);  (R-HSA-5673000);  (R-HSA-5674135);  (R-HSA-5675221);  (R-HSA-6802946);  (R-HSA-6802948);  (R-HSA-6802952);  (R-HSA-6802955);  (R-HSA-9649948);  (R-HSA-9656223)",
        "pathway_count": 10,
        "publication_count": 233,
        "publication_id_list": "10205168;10206983;10209122;10409742;10415025;10490027;10702794;10712905;10725339;10757792;10891492;11032810;11237011;11325826;11494123;11741534;11756411;11802164;11802165;12007434;12068308;12105213;12244094;12473660;12479806;12551923;12583813;12832465;12932319;12932339;12941695;14530258;14636584;14724641;14970219;15035987;15118098;15239952;15258589;15260967;15467451;15520807;15543157;15547943;15630448;15664191;15710605;15711535;15851477;15899852;16041367;16093354;16135787;16294014;16364920;16508002;16537381;16630891;16702958;16879721;16892053;17018604;17081983;17097642;17145850;17178906;17344846;17496912;17563371;17603482;17603483;17724343;18088087;18220336;18287029;18294816;18332145;18515281;18547165;18559533;18562239;18662992;18669648;18974108;19049963;19091303;19091743;19158341;19219045;19242111;19279408;19467855;19541618;19684605;19690332;19727074;19933846;20052757;20130576;20141835;20179705;20332238;20526349;20674547;20679487;20818844;20820846;20858867;21102438;21107323;21406692;21424530;21441104;21441910;21514245;21639808;21779496;21784453;21993244;22043453;22113612;22177953;22292133;22356324;22395615;22510884;22569528;22589270;22592532;22730326;22745804;22826437;22898188;23105109;23171796;23186163;23288408;23352452;23360980;23453624;23481700;23583981;23614898;23667175;23680146;23863182;23875798;23906342;23934108;23993095;24121058;24121489;24135138;24202393;24211266;24345920;24347342;24651010;24746704;24937142;24957944;25195011;25204415;25313996;25314968;25418920;25435214;25597358;25907612;25965804;26154972;26214590;26343583;26375851;26728094;26992070;27227380;27264673;27999210;28063628;28082416;28289718;28666118;28832583;28834231;28939558;28984291;29242379;29433126;29461827;29467321;29557506;29632046;30034615;30429286;30794926;31217245;31844290;32157095;32502341;3287375;33141586;33298915;33912179;34171305;34405274;34932366;35051231;36010968;36493900;37511580;37972068;7542586;7565670;7565795;7731720;7744815;7929275;7935411;8051079;8157000;8521512;8521513;8521514;8637718;8876196;8946910;9020159;9234708;9689060;9733512;9823899;9858547",
        "class_list": "",
        "function": "Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity)., [UniProtKB, UniProtKB, PubMed]; SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in KRAS-mutant gastric cancer through the suppression of KSR1 activity., [RefSeq, PubMed]; SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 12,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8WEA9;H7BYU0;Q13476",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.107",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107",
                "type": "external"
            },
            {
                "id": "2.7.1.94",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94",
                "type": "external"
            },
            {
                "id": "2.7.1.138",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.7.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-",
                "type": "external"
            },
            {
                "id": "2.7.7.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19",
                "type": "external"
            },
            {
                "id": "1.14.11.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65",
                "type": "external"
            },
            {
                "id": "3.1.31.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.31.1",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0071889 14-3-3 protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007265 Ras protein signal transduction;GO:0043405 regulation of MAP kinase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 23.4,
        "record_id": "Q8IVT5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z5Y7-1",
        "uniprot_id": [
            {
                "id": "KCD20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z5Y7",
                "type": "external"
            }
        ],
        "mass": 47480.0,
        "length": 419,
        "protein_name": "BTB/POZ domain-containing protein KCTD20",
        "gene_name": "KCTD20",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein KCTD20 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001273508",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273508",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCTD20; C6orf69",
        "gene_names_refseq": "C6orf69; KCTD20; dJ108K11.3",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD20; Potassium channel tetramerization domain containing 20",
        "protein_names_refseq": "BTB/POZ domain-containing protein KCTD20 isoform b; BTB/POZ domain-containing protein KCTD20; potassium channel tetramerisation domain containing 20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:222658)",
        "pathway_count": 1,
        "publication_count": 66,
        "publication_id_list": "11237011;14676191;18160138;22424782;22544926;23481700;23783831;24156551;24714562;24715725;25418920;25576301;25645385;25802875;26154972;26811146;26929215;26992070;27846572;27862975;27920218;28063628;28218747;28228285;28398603;28832583;28860189;28904123;29242379;29393594;29437277;29508533;29557506;29632046;29786170;30315122;30429286;30524438;30734435;31154438;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32938616;33298915;33592498;33717175;33968037;33982764;34185709;34211107;34405274;34509645;34561969;34932366;35051231;35580925;36010968;36284347",
        "class_list": "",
        "function": "Cocaine'omics: Genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence., [RefSeq, PubMed]; KCTD20 is a positive regulator of Akt and may play an important role in regulating the death and growth of some non-nervous and nervous cells. Publication Status: Online-Only, [RefSeq, PubMed]; Long noncoding RNA NEAT1 regulates glioma cell proliferation and apoptosis by competitively binding to microRNA3245p and upregulating KCTD20 expression., [RefSeq, PubMed]; Promotes the phosphorylation of AKT family members., [UniProtKB, UniProtKB]; Results suggest that Kctd20 impacts proliferation and invasion of non-small cell lung cancer through enhancing Fak and Akt phosphorylation, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZD3;B4E2Q3;F5H3T3;Q5W105;Q69YQ7;Q8IZ55",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0042327 positive regulation of phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q7Z5Y7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96LB3-1",
        "uniprot_id": [
            {
                "id": "IFT74_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96LB3",
                "type": "external"
            }
        ],
        "mass": 69239.0,
        "length": 600,
        "protein_name": "Intraflagellar transport protein 74 homolog",
        "gene_name": "IFT74",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 74 homolog isoform a",
        "refseq_ac": [
            {
                "id": "NP_001092692",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092692",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFT74; CCDC2; CMG1",
        "gene_names_refseq": "BBS22; CCDC2; CMG-1; CMG1; IFT74; JBTS40; SPGF58",
        "protein_names_uniprotkb": "Intraflagellar transport protein 74 homolog; CMG-1; Capillary morphogenesis gene 1 protein; Coiled-coil domain-containing protein 2",
        "protein_names_refseq": "capillary morphogenesis gene 1 protein; capillary morphogenesis protein 1; coiled-coil domain containing 2; coiled-coil domain-containing protein 2; intraflagellar transport 74 homolog; intraflagellar transport protein 74 homolog isoform a; intraflagellar transport protein 74 homolog",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Joubert syndrome (Disease Ontology:DOID:0050777); Bardet-Biedl syndrome 22 (Disease Ontology:DOID:0081011); spermatogenic failure 58 (Disease Ontology:DOID:0112352); Joubert syndrome 40 (MONDO:MONDO:0030462)",
        "pathway": " (hsa:80173);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 122,
        "publication_id_list": "10.1101/2023.09.13.557529;10069812;11237011;11285270;11683410;12795688;15024030;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22922713;22992454;23945166;23990561;24129315;24140113;24296415;24339792;24596149;24616010;24715725;25205765;25349261;25443296;26154972;26375851;26992070;27486776;27543614;27600516;27846572;27893789;27920218;28228285;28428259;28625565;28832583;28834231;28904123;29242379;29508533;29557506;29632046;30315122;30379171;30429286;30833945;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33531668;33592498;33689014;33717175;33912179;33968037;33981976;34171305;34211107;34357683;34405274;34509645;34539760;34561969;35051231;35154160;35580925;36010968;36284347;37217939;37315079;37555648;37938771;38253038;39894887;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014)., [UniProtKB, PubMed, PubMed]; Defective airway intraflagellar transport underlies a combined motile and primary ciliopathy syndrome caused by IFT74 mutations., [RefSeq, PubMed]; IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3B789;Q5VY34;Q6PGQ8;Q9H643;Q9H8G7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0048487 beta-tubulin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0035735 intraciliary transport involved in cilium assembly;GO:0035720 intraciliary anterograde transport;GO:0042073 intraciliary transport",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "Q96LB3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H583-1",
        "uniprot_id": [
            {
                "id": "HEAT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H583",
                "type": "external"
            }
        ],
        "mass": 242370.0,
        "length": 2144,
        "protein_name": "HEAT repeat-containing protein 1",
        "gene_name": "HEATR1",
        "organism": "Human",
        "refseq_name": "HEAT repeat-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_060542",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060542",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR1; BAP28; UTP10",
        "gene_names_refseq": "BAP28; HEATR1; UTP10",
        "protein_names_uniprotkb": "HEAT repeat-containing protein 1; Protein BAP28; U3 small nucleolar RNA-associated protein 10 homolog",
        "protein_names_refseq": "HEAT repeat-containing protein 1; U3 small nucleolar RNA-associated protein 10 homolog; UTP10, small subunit (SSU) processome component, homolog; protein BAP28",
        "tax_id": 9606,
        "disease": "glioblastoma (Disease Ontology:DOID:3068); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)",
        "pathway": " (hsa:55127);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 174,
        "publication_id_list": "10.1101/2023.09.13.557529;10606270;11081632;11237011;11922599;11935223;11978965;12068309;12150911;12417735;12429849;15199136;15777939;16037817;16043514;16381836;16738141;16782898;17189298;17353269;17412707;17488105;17525332;17636026;17699751;18065403;18438418;18452278;18691976;19033376;19106111;19332556;19463982;19564402;19801658;20038530;20047967;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;22072790;22190735;22195017;22223895;22424782;22898188;22916032;23186163;23301498;23391857;23439679;23481700;23482395;2388630;24086612;24366607;24424021;24550520;24714562;24715725;25411247;25418920;25525153;25576301;25645385;25653167;25851604;25892735;25969445;26085946;26154972;26196125;26237581;26375851;26811146;26992070;27084949;27600516;27846572;27862975;27893789;27920218;28218747;28228285;28510447;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;29789417;30315122;30410026;30429286;30524438;30568303;30779550;30833945;31092671;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32634230;32897882;32938616;32983136;33091337;33141586;33298915;33392160;33592498;33633747;33691108;33717175;33894417;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34516797;34561969;34725712;34932366;35051231;35251023;35318648;35494241;35561310;35580925;36215666;36241641;36284347;36581221;37247644;37938771;38225354;40914422;9211966;9482744;9512526",
        "class_list": "",
        "function": "HEATR1 promotes proliferation in gastric cancer in vitro and in vivo., [RefSeq, PubMed]; HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma., [RefSeq, PubMed]; Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, UniProtKB]; Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis., [RefSeq, PubMed]; Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth., [RefSeq, PubMed]; Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354)., [UniProtKB, PubMed, PubMed, PubMed]; Ribosome biogenesis factor; required for recruitment of Myc to nucleoli. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in neuronal-lineage cell proliferation., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T3Q8;Q6P197;Q9NW23",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0030515 snoRNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0001650 fibrillar center",
        "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:1902570 protein localization to nucleolus;GO:0006351 DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0061351 neural precursor cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 17.9,
        "record_id": "Q9H583-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2E2-1",
        "uniprot_id": [
            {
                "id": "KIF17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2E2",
                "type": "external"
            }
        ],
        "mass": 115068.0,
        "length": 1029,
        "protein_name": "Kinesin-like protein KIF17",
        "gene_name": "KIF17",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF17 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001274141",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274141",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF17; KIAA1405; KIF3X",
        "gene_names_refseq": "KIF17B; KIF17; KIF3X; KLP-2; OSM-3",
        "protein_names_uniprotkb": "Kinesin-like protein KIF17; KIF3-related motor protein",
        "protein_names_refseq": "KIF17 variant protein; KIF3-related motor protein; kinesin-like protein KIF17 isoform c; kinesin-like protein KIF17",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57576);  (R-HSA-5620924);  (R-HSA-9609736)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "10.1101/2023.09.13.557529;10069812;11237011;11285270;12795688;14673085;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;17855605;17997397;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22922713;22992454;23945166;23990561;24140113;24296415;24596149;24616010;25205765;25349261;25443296;26182404;28228285;28761002;29393594;29557506;30315122;30590034;31844290;32387766;33922911;39615683;39894887;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Biallelic Variants in KIF17 Associated with Microphthalmia and Coloboma Spectrum. Publication Status: Online-Only, [RefSeq, PubMed]; KIF17b serves as a molecular motor component of a TB-RBP-mouse ribonucleoprotein complex transporting a group of specific CREM-regulated mRNAs., [RefSeq, PubMed]; The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport., [RefSeq, PubMed]; Together with RAB23 and IFT57, it is required for the localization of specific G protein-coupled receptors, such as dopamime receptor DRD1, to primary cilia (PubMed:26182404). In association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3Q7;A2A3Q8;O95077;Q53YS6;Q5VWA9;Q6GSA8;Q8N411",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex",
        "go_biological_process": "GO:0015031 protein transport;GO:0030030 cell projection organization;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9P2E2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.1100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MW92-1",
        "uniprot_id": [
            {
                "id": "P20L1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MW92",
                "type": "external"
            }
        ],
        "mass": 115010.0,
        "length": 1017,
        "protein_name": "PHD finger protein 20-like protein 1",
        "gene_name": "PHF20L1",
        "organism": "Human",
        "refseq_name": "PHD finger protein 20-like protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_057102",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057102",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF20L1; CGI-72",
        "gene_names_refseq": "CGI-72; PHF20L1; TDRD20B; URLC1",
        "protein_names_uniprotkb": "PHD finger protein 20-like protein 1",
        "protein_names_refseq": "PHD finger protein 20-like protein 1 isoform 1; PHD finger protein 20-like protein 1; tudor domain containing 20B; tudor domain-containing protein PHF20L1; up-regulated in lung cancer 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51105);  (R-HSA-9772755)",
        "pathway_count": 2,
        "publication_count": 137,
        "publication_id_list": "11237011;12393701;12482972;12670868;14636557;14992727;15199122;16227571;16239140;16829959;16878130;16892064;17355966;17500065;17612494;17671196;17925232;17998332;18598942;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19556245;19608861;20018852;20575550;20716525;20961854;21106533;21124902;21131905;21135039;21220120;22266653;22327296;22652693;22665483;23481700;23508102;23995757;24244196;24275569;24368734;24492612;24680668;24714562;25418920;25561738;25576301;25593305;25645385;25802875;25880248;26154972;26324722;26375851;26588862;26728094;26886794;26992070;27563068;27600516;27698142;27760318;27846572;27920218;28063628;28182322;28228285;28398509;28832583;28834231;28841214;28904123;29138278;29242379;29331515;29358331;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29897600;29937342;30089852;30524438;31400120;31485071;31544921;31844290;32157095;32265295;32357974;32387766;32488085;32494608;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33657400;33691108;33847474;33912179;33936100;33968037;33981976;34012049;34087483;34171305;34405274;34509645;34933446;35033534;35051231;35190547;35357096;35439434;35561310;35580925;36010968;36215666;36241641;36284347;38411116;39302247",
        "class_list": "",
        "function": "An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer., [RefSeq, PubMed]; Associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by the MLL1/WDR5 complexes, [RefSeq, PubMed]; Authors find that the interplay between PHF20L1 and mono-methyl pRb is important for maintaining the integrity of a pRb-dependent G1-S-phase checkpoint. Results highlight the distinct roles that methyl-lysine readers have in regulating the biological activity of pRb., [RefSeq, PubMed]; Data suggest that, in human ovarian teratocarcinoma cell line, methylation-dependent proteolysis of SOX2 is controlled by LSD1 and PHF20L1 via regulation of SET7 activity; these data are consistent with previous studies in mouse primary stem cells. (SOX2 = SRY-box 2 transcription factor; LSD1 = lysine demethylase-1A; PHF20L1 = PHD finger protein 20 like-1; SET7 = histone-lysine N-methyltransferase SETD7), [RefSeq, PubMed]; Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Malignant brain tumor domain of PHF20L1 reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation., [RefSeq, PubMed]; PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrated the oncogenic potential of PHF20L1 and its association with poor prognostic parameters in breast cancer., [RefSeq, PubMed]; Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MZC9;Q86U89;Q86W43;Q96BT0;Q9H702;Q9HBK3;Q9NYR3;Q9Y381",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140034 methylation-dependent protein binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0044545 NSL complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0042177 negative regulation of protein catabolic process;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 14.1,
        "record_id": "A8MW92-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15229-1",
        "uniprot_id": [
            {
                "id": "KMO_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15229",
                "type": "external"
            }
        ],
        "mass": 55810.0,
        "length": 486,
        "protein_name": "Kynurenine 3-monooxygenase",
        "gene_name": "KMO",
        "organism": "Human",
        "refseq_name": "kynurenine 3-monooxygenase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_003670",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003670",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KMO",
        "gene_names_refseq": "KMO; dJ317G22.1",
        "protein_names_uniprotkb": "Kynurenine 3-monooxygenase; 1.14.13.9; Kynurenine 3-hydroxylase",
        "protein_names_refseq": "kynurenine 3-hydroxylase; kynurenine 3-monooxygenase isoform 1",
        "tax_id": 9606,
        "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)",
        "pathway": " (hsa:8564);  (R-HSA-71240)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10049700;10391915;10672018;11237011;12007602;12140278;12402501;13069505;15364907;15880762;16376499;16477023;17671174;18056995;18262359;18620547;19338303;21097500;23478338;23575632;25576301;26154972;26752518;26992070;27600516;27862975;28604669;28832583;28834231;29208702;29242379;29429898;29557506;29789417;30429286;30833945;31217245;31844290;31848261;32157095;32387766;32488085;32938616;33091337;33691108;34171305;34932366;35011505;35051231;35580925;38040995;38497113;39026250;7514594;7883047;8294935;8666386;9180257;9237672",
        "class_list": "",
        "function": "Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson's Disease Patients., [RefSeq, PubMed]; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702, PubMed:29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque. Publication Status: Online-Only, [RefSeq, PubMed]; Kynurenine 3-monooxygenase limits de novo NAD[+] synthesis through dietary tryptophan in renal proximal tubule epithelial cell models., [RefSeq, PubMed]; The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2U8;A2A2U9;A2A2V0;Q5SY07;Q5SY08;Q5SY09",
        "ec_number_list": [
            {
                "id": "1.14.13.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.9",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004502 kynurenine 3-monooxygenase activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0097052 L-kynurenine metabolic process;GO:0006569 L-tryptophan catabolic process;GO:0070189 kynurenine metabolic process;GO:0071222 cellular response to lipopolysaccharide",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "O15229-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBP9-1",
        "uniprot_id": [
            {
                "id": "GULP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBP9",
                "type": "external"
            }
        ],
        "mass": 34490.0,
        "length": 304,
        "protein_name": "PTB domain-containing engulfment adapter protein 1",
        "gene_name": "GULP1",
        "organism": "Human",
        "refseq_name": "PTB domain-containing engulfment adapter protein 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001239597",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239597",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GULP1; CED6; GULP",
        "gene_names_refseq": "CED-6; CED6; GULP1; GULP",
        "protein_names_uniprotkb": "PTB domain-containing engulfment adapter protein 1; Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP",
        "protein_names_refseq": "GULP, engulfment adaptor PTB domain containing 1; PTB domain adapter protein CED-6; PTB domain adaptor protein CED-6; PTB domain-containing engulfment adapter protein 1 isoform b; PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog; engulfment adapter protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51454)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "10574763;10574771;10734103;11237011;11729193;16497666;17205124;17398097;17643423;18220336;18230608;18491316;19651622;20068231;23186163;25576301;25645385;28228285;30379171;31373844;31409653;31516309;31844290;32817372;33981976;34019948;35580925;36010968;39467629",
        "class_list": "",
        "function": "GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis, [RefSeq, PubMed]; GULP1 as a Downstream Effector of the Estrogen Receptor-beta Modulates Cisplatin Sensitivity in Bladder Cancer., [RefSeq, PubMed]; GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)., [RefSeq, PubMed]; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results indicate that GULP, engulfment adaptor PTB domain containing 1 (GULP1) threonine 35 (T35) phosphorylation is a mechanism for the regulation of GULP1-amyloid beta precursor protein (APP) interaction and thereby APP processing., [RefSeq, PubMed]; The knockdown of GULP1 and ABR using siRNAs decreased phagocytosis by 40%. Publication Status: Online-Only, [RefSeq, PubMed]; The phagocytic adaptor protein Gulp1 regulates EphB/ephrinB trogocytosis to achieve efficient cell rearrangements of cultured cells and during embryonic development, [RefSeq, PubMed]; The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RB51;B4DQ40;B8ZZ72;D3DPH1;E9PB86;Q53PC1;Q53RF3;Q9BVL3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006869 lipid transport;GO:0006911 phagocytosis, engulfment;GO:0006915 apoptotic process;GO:0006909 phagocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9UBP9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q659A1-1",
        "uniprot_id": [
            {
                "id": "ICE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q659A1",
                "type": "external"
            }
        ],
        "mass": 110011.0,
        "length": 982,
        "protein_name": "Little elongation complex subunit 2",
        "gene_name": "ICE2",
        "organism": "Human",
        "refseq_name": "little elongation complex subunit 2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001018099",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018099",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICE2; BRCC1; NARG2; PRO10100",
        "gene_names_refseq": "BRCC1; ICE2; NARG2",
        "protein_names_uniprotkb": "Little elongation complex subunit 2; Interactor of little elongator complex ELL subunit 2; NMDA receptor-regulated protein 2",
        "protein_names_refseq": "NMDA receptor regulated 2; NMDA receptor-regulated gene 2; NMDA receptor-regulated protein 2; breast cancer cell 1; interactor of little elongator complex ELL subunit 2; little elongation complex subunit 2 isoform b; little elongation complex subunit 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79664);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10022900;11237011;11856838;12414730;12574128;12975309;14701755;1535687;15606750;16239144;16308568;16901896;1739980;18079403;1829677;18669648;19413330;19667075;20068231;20457598;2125285;22137580;22195968;22231121;22252320;22441827;23166507;23186163;23932780;24097444;24270878;24397554;24997600;25418920;25576301;25645385;25675981;25802875;25880248;25892735;26154972;26811146;26992070;27846572;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29393594;2944599;29557506;29769354;29786170;30315122;30410026;30429286;30779550;30833945;31092671;31154438;31217245;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34509645;34932366;35051231;35580925;36010968;36215666;36241641;38253038;39531497;7715707;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III., [UniProtKB, PubMed]; This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RU08;Q05CT1;Q3B7W6;Q63HP4;Q658Q0;Q68CN8;Q6IPW7;Q6UX23;Q71H65;Q96CY5;Q9HAA2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016604 nuclear body;GO:0015030 Cajal body;GO:0000791 euchromatin",
        "go_biological_process": "GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q659A1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P07099-1",
        "uniprot_id": [
            {
                "id": "HYEP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P07099",
                "type": "external"
            }
        ],
        "mass": 52949.0,
        "length": 455,
        "protein_name": "Epoxide hydrolase 1",
        "gene_name": "EPHX1",
        "organism": "Human",
        "refseq_name": "epoxide hydrolase 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_000111",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000111",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHX1; EPHX; EPOX",
        "gene_names_refseq": "EPHX1; EPHX; EPOX; HYL1; MEH",
        "protein_names_uniprotkb": "Epoxide hydrolase 1; 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH",
        "protein_names_refseq": "epoxide hydratase; epoxide hydrolase 1 isoform a; epoxide hydrolase 1 microsomal; epoxide hydrolase 1, microsomal (xenobiotic)",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); withdrawal disorder (Disease Ontology:DOID:0060001); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); bone disease (Disease Ontology:DOID:0080001); acromesomelic dysplasia 4 (Disease Ontology:DOID:0081238); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); asbestosis (Disease Ontology:DOID:10320); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); aplastic anemia (Disease Ontology:DOID:12449); malignant renovascular hypertension (Disease Ontology:DOID:13730); Parkinson's disease (Disease Ontology:DOID:14330); respiratory system disease (Disease Ontology:DOID:1579); anemia (Disease Ontology:DOID:2355); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:2052);  (R-HSA-211945)",
        "pathway_count": 2,
        "publication_count": 135,
        "publication_id_list": "10445380;10945627;11058921;11154734;11237011;11255266;11422004;12173035;12725862;12732646;12878321;1351198;14669306;15350128;15492766;15523003;15535985;15618730;16005144;16614850;16765324;17400359;18199464;18254726;18256025;18258609;18285471;18406439;19053771;19588076;19764817;20007405;20068231;20112406;20177059;20422440;20542992;21302624;22352736;22700792;22798687;22813719;23564882;23616950;23681797;23953689;24222229;24423752;24615030;24677340;24900196;24958911;25144769;25222243;25418920;25425164;25446851;25576301;25714851;25880248;25923589;25923690;26065263;26295053;26811146;26853435;26992070;27452731;27600516;27920218;28018104;28218747;28510447;28904123;2891713;2897122;29242379;29393594;29437277;29557506;29605894;29632046;29786170;30315122;30429286;30524438;30779550;30833945;31020640;31154438;31222486;31844290;31848261;32152082;32157095;32171872;32187464;32205870;32210741;32265295;32357974;32387766;32488085;32938616;32983136;33298915;33537174;33592498;33968037;33981976;34087483;34171305;34357683;34411648;34672683;34725712;3502697;35051231;35251023;35580925;36010968;36215666;36241641;36284347;36591768;37938771;38665916;7516776;7835893;7980644;8944076;8985016;9169443;9367528;9653080",
        "class_list": "",
        "function": "ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients. Review article, [RefSeq, PubMed]; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; EPHX1 transcript, termed E1-b', drives EPHX1 expression primarily in the ovary., [RefSeq, PubMed]; EPOXID HYDROLASE SINGLE GENE POLYMORPHISM (RS1051740) AND SEVERITY OF CHRONIC OBSTRUCTIVE DISEASE., [RefSeq, PubMed]; Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]., [RefSeq]; Genetic polymorphisms in the mEH gene in relation to tobacco smoking: role in lung cancer susceptibility and survival in north Indian patients with lung cancer undergoing platinum-based chemotherapy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 25,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8N0;Q5VTJ6;Q9NP75;Q9NPE7;Q9NQU6;Q9NQU7;Q9NQU8;Q9NQU9;Q9NQV0;Q9NQV1;Q9NQV2",
        "ec_number_list": [
            {
                "id": "3.5.1.99",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.56",
                "type": "external"
            },
            {
                "id": "3.1.1.84",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.84",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.3.2.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
                "type": "external"
            },
            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004301 epoxide hydrolase activity;GO:0033961 cis-stilbene-oxide hydrolase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0009636 response to toxic substance;GO:0019369 arachidonate metabolic process;GO:0097176 epoxide metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "P07099-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21583-1",
        "uniprot_id": [
            {
                "id": "SCF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21583",
                "type": "external"
            }
        ],
        "mass": 30899.0,
        "length": 273,
        "protein_name": "Kit ligand",
        "gene_name": "KITLG",
        "organism": "Human",
        "refseq_name": "kit ligand isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_000890",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000890",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KITLG; MGF; SCF",
        "gene_names_refseq": "DCUA; DFNA69; FPH2; FPHH; KITLG; KL-1; Kitl; MGF; SCF; SF; SHEP7; SLF; WS2F",
        "protein_names_uniprotkb": "Kit ligand; MGF; Mast cell growth factor; SCF; Stem cell factor; c-Kit ligand",
        "protein_names_refseq": "c-Kit ligand; familial progressive hyperpigmentation 2; kit ligand isoform b precursor; mast cell growth factor; steel factor; stem cell factor",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 69 (Disease Ontology:DOID:0110590); familial progressive hyperpigmentation with or without hypopigmentation (Disease Ontology:DOID:0111373); pigmentation disease (Disease Ontology:DOID:10123); Waardenburg syndrome (Disease Ontology:DOID:9258); Waardenburg syndrome 2F (MONDO:MONDO:0030983)",
        "pathway": " (hsa:4254)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10049787;10582791;10880433;10884405;11237011;1379846;1381905;15526160;15625120;1724381;17662946;17952075;19375057;2208279;23584533;24880339;25576301;25813380;26522471;27600516;28504826;29557506;29789417;30779550;31254605;31844290;32161166;32257537;32292113;32561706;32576222;32938616;32983136;33592498;33968037;34171305;35051231;35543077;35580925;36233032;36241641;36242590;37074911;37174705;38206705;38507654",
        "class_list": "",
        "function": "Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells. Publication Status: Online-Only, [RefSeq, PubMed]; DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway., [RefSeq, PubMed]; Effects of stem cell factor in follicular fluid and granulosa cells on oocyte maturity and clinical pregnancy., [RefSeq, PubMed]; KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins., [UniProtKB]; Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia., [RefSeq, PubMed]; This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic; monitoring",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV09;A8K2Q4;B7ZLM4;Q16487;Q68DZ2;Q7M4N8;Q9UQK7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0008584 male gonad development;GO:0001541 ovarian follicle development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "P21583-1",
        "record_type": "protein",
        "filter_code": "0101000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5SSJ5-1",
        "uniprot_id": [
            {
                "id": "HP1B3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5SSJ5",
                "type": "external"
            }
        ],
        "mass": 61207.0,
        "length": 553,
        "protein_name": "Heterochromatin protein 1-binding protein 3",
        "gene_name": "HP1BP3",
        "organism": "Human",
        "refseq_name": "heterochromatin protein 1-binding protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_057371",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057371",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HP1BP3",
        "gene_names_refseq": "HP1-BP74; HP1BP3; HP1BP74",
        "protein_names_uniprotkb": "Heterochromatin protein 1-binding protein 3; Protein HP1-BP74",
        "protein_names_refseq": "heterochromatin protein 1-binding protein 3 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:50809)",
        "pathway_count": 1,
        "publication_count": 107,
        "publication_id_list": "10931946;11237011;17081983;17287340;17525332;17693683;18452278;18669648;19165527;19367720;19651622;19691289;20042602;20058876;20068230;20068231;20800603;21406692;22645359;23186163;23481700;24317310;24715725;24830416;25100860;25576301;25645385;26154972;26992070;27425409;27452731;27726376;27846572;27920218;28218747;28228285;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30484775;30524438;30779550;31092671;31154438;31217245;31530632;31819167;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32502341;32870666;32897882;32938616;32983136;33043033;33123756;33141586;33214551;33298915;33392160;33465208;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34171305;34185709;34211107;34357683;34509645;34561969;34932366;35051231;35083852;35251023;35254053;35318648;35580925;36010968;36284347;36517590;37217939;37340703;38665916;40596516;40914422",
        "class_list": "",
        "function": "A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen., [RefSeq, PubMed]; Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860)., [UniProtKB, PubMed, PubMed]; EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma., [RefSeq, PubMed]; Found two biomarker loci at HP1BP3 and TTC9B, which predicted postpartum depression, [RefSeq, PubMed]; HP1-BP74 directly binds to HP1, and its middle region associates with linker DNA at the entry/exit site of nucleosomal DNA in vitro, [RefSeq, PubMed]; HP1BP3 promotes co-transcriptional miRNA processing via chromatin retention of nascent pri-miRNA transcripts., [RefSeq, PubMed]; HP1BP3 protein maintains heterochromatin integrity during G1-S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NI71;A8K5D7;B3KMZ8;B4E210;Q05BI0;Q5SSJ6;Q5SWC6;Q6PIM9;Q8NDF0;Q9UHY0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0031491 nucleosome binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0071456 cellular response to hypoxia;GO:0006334 nucleosome assembly;GO:0097298 regulation of nucleus size",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "Q5SSJ5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P46013-1",
        "uniprot_id": [
            {
                "id": "KI67_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P46013",
                "type": "external"
            }
        ],
        "mass": 358694.0,
        "length": 3256,
        "protein_name": "Proliferation marker protein Ki-67",
        "gene_name": "MKI67",
        "organism": "Human",
        "refseq_name": "proliferation marker protein Ki-67 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001139438",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139438",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MKI67",
        "gene_names_refseq": "KIA; MIB-1; MIB-; MKI67; PPP1R105",
        "protein_names_uniprotkb": "Proliferation marker protein Ki-67; Antigen KI-67; Antigen Ki67; Antigen identified by monoclonal antibody Ki-67",
        "protein_names_refseq": "Molecular Immunology Borstel antibody 1; antigen Ki67; antigen identified by monoclonal antibody Ki-67; proliferation marker protein Ki-67 isoform 2; proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105",
        "tax_id": 9606,
        "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); mucositis (Disease Ontology:DOID:0080178); graft-versus-host disease (Disease Ontology:DOID:0081267); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); neutropenia (Disease Ontology:DOID:1227); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cholangiocarcinoma (Disease Ontology:DOID:4947); adult pineal parenchymal tumor (Disease Ontology:DOID:5031); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); kidney disease (Disease Ontology:DOID:557); hepatoblastoma (Disease Ontology:DOID:687); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); Barrett's esophagus (Disease Ontology:DOID:9206); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:4288)",
        "pathway_count": 1,
        "publication_count": 180,
        "publication_id_list": "10502411;10653604;10878014;10878551;11342549;14659764;15302935;15896774;16244663;16565220;16964243;17081983;17287340;17322306;17924679;18212344;18220336;18234856;18452278;18491316;18669648;18691976;18767875;18991276;19007248;19131338;19369195;19413330;19415658;19608861;19651622;19664994;19664995;19690332;19691289;20058876;20068230;20068231;20305658;21406692;21960707;22002106;22706990;23178126;23186163;23301498;23481700;23645542;24366607;24714562;24715725;24867636;25012651;25114211;25218447;25418920;25502872;25505266;25576301;25645385;25755297;25772364;25810538;25880248;25892735;26154972;26375851;26680267;26728094;2674163;26811146;26853435;26929215;26992070;27362226;27600516;27846572;27920218;28063628;28218747;28228285;28352266;28514659;28649982;28832583;28834231;28855257;28904123;28935370;29093164;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;29789417;30059200;30315122;30379171;30429286;30484775;30524438;30620550;31217245;31530632;31844290;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32574038;32879492;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34185709;34211107;34433824;34561969;34725712;34846842;34932366;34942119;35051231;35083852;35132862;35154160;35251023;35254053;35318648;35513709;35561310;35580925;35705054;36010968;36215666;36241641;36284347;37217939;37938771;38253038;38838015;39078783;39153474;39304838;40307207;40596516;40914422;6206131;6339421;8227122;8799815;9510506",
        "class_list": "",
        "function": "Expression of cytokeratin 7/20 and Ki67 in Helicobacter pylori-associated gastritis and intestinal metaplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Relationship between p16/ki67 immunoscores and PAX1/ZNF582 methylation status in precancerous and cancerous cervical lesions in high-risk HPV-positive women. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 30,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 30,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 30,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 217,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 115,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "predictive",
        "glycan_count": 1,
        "disease_count": 29,
        "glyco_site_count": 30,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VWH2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0140693 molecular condensate scaffold activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016020 membrane;GO:0000793 condensed chromosome",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0008283 cell population proliferation;GO:0007088 regulation of mitotic nuclear division;GO:0051321 meiotic cell cycle;GO:1902275 regulation of chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 21.2,
        "record_id": "P46013-1",
        "record_type": "protein",
        "filter_code": "0010000.1100111.001000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQR1-1",
        "uniprot_id": [
            {
                "id": "KMT5A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQR1",
                "type": "external"
            }
        ],
        "mass": 42890.0,
        "length": 393,
        "protein_name": "N-lysine methyltransferase KMT5A",
        "gene_name": "KMT5A",
        "organism": "Human",
        "refseq_name": "N-lysine methyltransferase KMT5A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001311433",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311433",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KMT5A; PRSET7; SET07; SET8; SETD8",
        "gene_names_refseq": "KMT5A; PR-Set7; PR/SET07; SET07; SET8; SETD8",
        "protein_names_uniprotkb": "N-lysine methyltransferase KMT5A; 2.1.1.-; 2.1.1.361; H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; PR-Set7; PR/SET domain-containing protein 07; PR/SET07; SET domain-containing protein 8",
        "protein_names_refseq": "H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; N-lysine methyltransferase KMT5A isoform 2; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine (K)-specific methyltransferase 5A; lysine N-methyltransferase 5A; lysine-specific methylase 5A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:387893);  (R-HSA-2299718);  (R-HSA-3214841);  (R-HSA-6804760);  (R-HSA-9764725)",
        "pathway_count": 5,
        "publication_count": 144,
        "publication_id_list": "10518217;10655587;10949293;11237011;11511361;11912130;11959841;12086618;12121615;12123582;12130538;12208845;12453418;12540855;12670868;12700765;14536086;14690610;14992727;15145825;15200950;15235609;15448695;15525938;15542832;15750587;15933069;15933070;15964846;16118227;16199523;16292313;16415881;16517599;16519522;16682010;16805913;17021013;17108971;17130829;17170761;17500065;17544230;17707229;17707234;18172012;18211953;18367646;18408754;18669648;18718915;18833288;19011621;19808676;20068231;20118233;20418909;20551165;20551166;20622854;20870725;20871592;20966048;21131967;21196496;21498573;21515671;21625555;21779408;21832073;21911480;22099308;22158034;22362889;22939622;23186163;23466526;23468428;23478445;23498719;24714562;24715725;25576301;25728771;26212009;26666832;26728094;26811146;26992070;27058226;27338793;27649746;27846572;27920218;28514659;28832583;28834231;28904123;29093164;29242379;29393594;29557506;29632046;29729076;29769354;29786170;29789417;30620550;30779550;30898548;31844290;31848261;31937595;32157095;32387766;32488085;32502341;33141586;33298915;33592498;33608512;33691108;33717175;33912179;33936100;33981976;34171305;34211107;34932366;35008676;35051231;35138000;35292107;35318648;35580925;35851744;36010968;36149050;36241641;36921492;38301049;38565081;38963044;40596516",
        "class_list": "",
        "function": "Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer., [RefSeq, PubMed]; Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification., [RefSeq, PubMed]; KMT5A Knockdown Suppresses Osteosarcoma Cell Proliferation and Metastasis Through -Catenin Signalling. Publication Status: Online-Only, [RefSeq, PubMed]; Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/beta-Catenin Signaling Pathway., [RefSeq, PubMed]; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793). Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599, PubMed:27338793). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Involved in chromosome condensation and proper cytokinesis (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Nucleosomes are preferred as substrate compared to free histones (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (PubMed:17707234). Plays a negative role in TGF-beta response regulation and a positive role in cell migration (PubMed:23478445)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SETD8 promotes glycolysis in colorectal cancer via regulating HIF1alpha/HK2 axis., [RefSeq, PubMed]; The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9D0;Q86W83;Q8TD09",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.98",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98",
                "type": "external"
            },
            {
                "id": "2.1.1.362",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362",
                "type": "external"
            },
            {
                "id": "2.1.1.361",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.286",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.355",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355",
                "type": "external"
            },
            {
                "id": "2.1.1.354",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016278 lysine N-methyltransferase activity;GO:0003714 transcription corepressor activity;GO:0042054 histone methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005700 polytene chromosome;GO:0005694 chromosome",
        "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 14.7,
        "record_id": "Q9NQR1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N5H7-1",
        "uniprot_id": [
            {
                "id": "SH2D3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N5H7",
                "type": "external"
            }
        ],
        "mass": 94411.0,
        "length": 860,
        "protein_name": "SH2 domain-containing protein 3C",
        "gene_name": "SH2D3C",
        "organism": "Human",
        "refseq_name": "SH2 domain-containing protein 3C isoform c",
        "refseq_ac": [
            {
                "id": "NP_001136004",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136004",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SH2D3C; NSP3; PRO34088",
        "gene_names_refseq": "CHAT; NSP3; PRO34088; SH2D3C; SHEP1",
        "protein_names_uniprotkb": "SH2 domain-containing protein 3C; Cas/HEF1-associated signal transducer; Chat-H; Novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1; SHEP1",
        "protein_names_refseq": "SH2 domain-containing Eph receptor-binding protein 1; SH2 domain-containing protein 3C isoform c; cas/HEF1-associated signal transducer; novel SH2-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10044)",
        "pathway_count": 1,
        "publication_count": 72,
        "publication_id_list": "10187783;11237011;12432078;12486027;12975309;16497976;17174122;18491316;18991276;19901323;20881139;22081014;22424782;23186163;23481700;23783831;24029068;24366607;24715725;25576301;26375851;26992070;27846572;27862975;27869121;27920218;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;31154438;31530632;31844290;31848261;31998317;32157095;32265295;32357974;32387766;32502341;32938616;32983136;33043033;33123756;33141586;33298915;33592498;33717175;33912179;33936100;34185709;34509645;34561969;34932366;35051231;35580925;36010968;36284347;37938771;40914422",
        "class_list": "",
        "function": "Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity)., [UniProtKB, UniProtKB]; May be involved in the BCAR1/CAS-mediated JNK activation pathway., [UniProtKB, UniProtKB]; The structure of the NSP3-p130Cas complex reveals that this closed conformation is instrumental for interaction of NSP proteins with a focal adhesion-targeting domain present in Cas proteins. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]; This protein positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5S8;E9PG48;Q5HYE5;Q5JU31;Q6UY42;Q8N6X3;Q9Y2X5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0032587 ruffle membrane",
        "go_biological_process": "GO:0007254 JNK cascade;GO:0007264 small GTPase-mediated signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q8N5H7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13242-1",
        "uniprot_id": [
            {
                "id": "SRSF9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13242",
                "type": "external"
            }
        ],
        "mass": 25542.0,
        "length": 221,
        "protein_name": "Serine/arginine-rich splicing factor 9",
        "gene_name": "SRSF9",
        "organism": "Human",
        "refseq_name": "serine/arginine-rich splicing factor 9",
        "refseq_ac": [
            {
                "id": "NP_003760",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003760",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SRSF9; SFRS9; SRP30C",
        "gene_names_refseq": "SFRS9; SRSF9; SRp30c",
        "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 9; Pre-mRNA-splicing factor SRp30C; Splicing factor, arginine/serine-rich 9",
        "protein_names_refseq": "SR splicing factor 9; pre-mRNA-splicing factor SRp30C; serine/arginine-rich splicing factor 9; splicing factor, arginine/serine-rich 9",
        "tax_id": 9606,
        "disease": "urinary bladder cancer (Disease Ontology:DOID:11054)",
        "pathway": " (hsa:8683);  (R-HSA-159236);  (R-HSA-72163);  (R-HSA-72187);  (R-HSA-72203);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 7,
        "publication_count": 270,
        "publication_id_list": "10022843;10196175;10228171;10323864;10489353;10668806;10669729;10882114;11014198;11060040;11073998;11101529;11233976;11237011;11256625;11259411;11259602;11579093;11694584;11739738;11747608;11756420;11875052;11979277;11991638;12024014;12093754;12176931;12411573;12414731;12477934;12604611;12871933;14519844;14625303;14713954;14749727;14762106;15009090;15009664;15037765;15084397;15302935;15565158;15695522;15998806;16314397;16314458;16809785;16964243;17000901;17016520;17081983;17095540;17128255;17190602;17287340;17322306;17332742;17389395;17606899;17924679;17984224;18212344;18288197;18322460;18364396;18411249;18423201;18452278;18593880;18669648;18691976;18707149;18767875;18957205;19103666;19165350;19217410;19367720;19523114;19536130;19651622;19664995;19836239;20058876;20068230;20068231;20129943;20166139;20230923;20423332;20573985;20695905;20844015;20980672;21295486;21406692;21536652;2176635;21872626;21911577;21947206;22110043;22207203;22365833;22813749;22893130;22928037;22959432;22961380;23186163;23222130;23236153;23299939;23345524;23481700;23826332;23874216;24076191;24149845;24196718;24244187;24275569;24304693;24316715;24407421;24448447;24714562;24715725;24737827;24914973;24981863;25301780;25301781;25418920;25555158;25576301;2558966;25645385;25662211;25810538;25836925;25892735;26092250;26154972;26375851;26385511;26420826;26728094;26929215;26969736;26992070;27108190;27377154;27459055;27600516;27683217;27846572;27920218;28062851;28076346;28096519;28218747;28228285;28502770;28514659;28781166;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29301961;29331515;29360106;29361316;29393594;29437277;29493099;29557506;29632046;29632711;2963332;29769354;29786170;29902443;30139799;30257008;30315122;30315277;30429286;30444036;30599162;30705154;30728453;30765414;30833945;30975767;31154438;31409651;31530632;31844290;31848261;32157095;32179686;32329775;32387766;32494006;32502341;32816001;32897882;32938616;32983136;33177556;33214551;33243851;33446560;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34229054;34301950;34822310;34932366;35051231;35177536;35215846;35385551;35561310;35580925;35971121;36010968;36284347;36330710;3757028;37938771;38665916;38771720;38810124;38842611;40914422;7556075;8352591;8566756;8608946;9016565;9242493;9409616;9512519;9524131;9539711;9618489;9659921;9660949;9671485;9671816;9685386;9701291;9731529",
        "class_list": "",
        "function": "EEF1D stabilized by SRSF9 promotes colorectal cancer via enhancing the proliferation and metastasis., [RefSeq, PubMed]; High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of the effect of SRSF9 overexpression on HIV-1 production., [RefSeq, PubMed]; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; SRSF9 promotes cell proliferation and migration of glioblastoma through enhancing CDK1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4., [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LD1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005634 nucleus",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition;GO:0000381 regulation of alternative mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "Q13242-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2D0-1",
        "uniprot_id": [
            {
                "id": "IBTK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2D0",
                "type": "external"
            }
        ],
        "mass": 150528.0,
        "length": 1353,
        "protein_name": "Inhibitor of Bruton tyrosine kinase",
        "gene_name": "IBTK",
        "organism": "Human",
        "refseq_name": "inhibitor of Bruton tyrosine kinase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001287835",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287835",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IBTK; BTKI; KIAA1417",
        "gene_names_refseq": "BTBD26; BTKI; IBTK",
        "protein_names_uniprotkb": "Inhibitor of Bruton tyrosine kinase; IBtk",
        "protein_names_refseq": "BTK-binding protein; Bruton agammaglobulinemia tyrosine kinase inhibitor; inhibitor of Bruton tyrosine kinase isoform 2; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25998)",
        "pathway_count": 1,
        "publication_count": 75,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11577348;18452278;18596081;18669648;18707149;19651622;19782003;20068231;20721470;21406692;21482705;23186163;23271734;24275569;24397554;24715725;25576301;25882842;26154972;26811146;27600516;27827994;27846572;27920218;28228285;28510447;28514659;28710282;28832583;28834231;28904123;29242379;29317636;29393594;29493099;29557506;29632711;29769354;30315122;30429286;30484775;30524438;31092671;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33091337;33141586;33298915;33592498;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34509645;34932366;35051231;35154160;35216159;35580925;36010968;36241641;36284347;37340703",
        "class_list": "",
        "function": "Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]., [RefSeq]; CRL3(IBTK) is a novel ubiquitin ligase with regulatory roles in cellular pathways, such as the Pdcd4-dependent translation of mRNAs, [RefSeq, PubMed]; Data suggest that IBTKalpha is (a) localized in hepatocytes in endoplasmic reticulum (ER), (b) associates with specific proteins (LC3b, SEC16A, SEC31A), and (c) plays role in autophagy. Progression of nonalcoholic fatty liver disease is associated with changes in liver: (a) up-regulation of expression of IBTKalpha, (b) unfolded protein response, (c) ER stress, and (d) inhibition of autophagy., [RefSeq, PubMed]; IBtkalpha Activates the beta-Catenin-Dependent Transcription of MYC through Ubiquitylation and Proteasomal Degradation of GSK3beta in Cancerous B Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of three IBTKalpha, IBTKbeta and IBTKgamma mRNAs, whose transcription is driven by two distinct promoter regions., [RefSeq, PubMed]; RNA interference of Inhibitor of brutons tyrosine kinase-isoform alpha up regulated the expression of pro-apoptotic genes, including TNF, CRADD, CASP7, BNIP3 and BIRC3 and is a novel marker of CLL progression promoting cell growth and resistance to apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; The IBTK gene encodes the proteins IBtk-alpha, beta and gamma that regulate the B cell receptor signalling through Bruton's tyrosine kinase, which promotes B cell survival and differentiation., [RefSeq, PubMed]; The results indicate that IBTKa differently modulates gene expression and RNA splicing in HeLa and K562 cells, demonstrating a novel biological role of this protein. Publication Status: Online-Only, [RefSeq, PubMed]; Three novel (Ala347fsX55, I355T, and Thr324fsX24) mutations in Bruton's tyrosine kinase in patients with X-linked agammaglobulinemia, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2QKU2;Q2QKU3;Q2QKU4;Q5TFD7;Q5TFD9;Q8IUQ9;Q8IUY7;Q8TAI4;Q9HBI8;Q9Y3T8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030292 protein tyrosine kinase inhibitor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0051209 release of sequestered calcium ion into cytosol",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q9P2D0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NS87-1",
        "uniprot_id": [
            {
                "id": "KIF15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NS87",
                "type": "external"
            }
        ],
        "mass": 160160.0,
        "length": 1388,
        "protein_name": "Kinesin-like protein KIF15",
        "gene_name": "KIF15",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF15",
        "refseq_ac": [
            {
                "id": "NP_064627",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064627",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF15; KLP2; KNSL7",
        "gene_names_refseq": "BRDCS2; HKLP2; KIF15; KLP2; KNSL7; NY-BR-62",
        "protein_names_uniprotkb": "Kinesin-like protein KIF15; Kinesin-like protein 2; Kinesin-like protein 7; Serologically defined breast cancer antigen NY-BR-62; hKLP2",
        "protein_names_refseq": "kinesin-like 7; kinesin-like protein 2; kinesin-like protein 7; kinesin-like protein KIF15; serologically defined breast cancer antigen NY-BR-62",
        "tax_id": 9606,
        "disease": "braddock-carey syndrome 2 (MONDO:MONDO:0859570)",
        "pathway": " (hsa:56992);  (R-HSA-2132295);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 4,
        "publication_count": 253,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10052452;10064083;10072072;10318838;10445031;10480952;10540230;10559959;10593899;10631941;10631952;10639150;10748235;10761932;10809954;10878014;10921873;11172815;11237011;11493604;11529500;11684289;11689559;11703931;11726511;11739780;11748249;11782313;11790530;11813165;11853874;12047556;12070132;12078484;12198549;12368902;12612055;12742663;12747765;12748383;1406973;14504276;14654841;14731593;15029241;15037235;15272311;15326200;15616190;15632110;15749704;15813748;15911768;16030262;1607388;16181339;16242130;16262723;1631136;16571679;16618111;16633337;1680566;16824007;16912714;16926190;16940185;17113389;17142755;17253781;17283181;17346968;17360540;17429068;17451557;17538014;17760859;17927562;17956946;18046453;18182008;18287528;18292509;18342609;18452278;18524849;18669648;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1956401;19564404;1957170;19608861;19631211;19691289;19758564;19818618;19818619;20005805;20068231;20136777;20357002;20427317;20462495;20534429;20637885;21116285;2121367;21219331;2142332;21441454;21550981;21689688;21844168;2190094;22013193;22094269;22304919;22645359;23186163;23301498;23396477;23481700;2391366;24366607;24714562;24715725;2521221;2522352;25364732;25436559;25492864;25576301;25645385;25892735;26992070;27354041;27600516;28150392;28218747;28228285;28411811;28832583;28834231;28904123;29242379;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30484775;30524438;31092671;31217245;3130248;3134048;31844290;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33091337;33141586;33298915;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34211107;34357683;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36241641;36280663;36807568;37777755;38598297;39430242;39894887;7481823;7528108;7539720;7592972;7650016;7667286;7822426;7844144;7929562;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8221884;8253837;8313912;8397411;8415765;8505331;8548803;8599929;8602245;8620540;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9114004;9177194;9202021;9244307;9288971;9311912;9312039;9405360;9497313;9539769;9545226;9606180;9751720;9990005",
        "class_list": "",
        "function": "Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly., [RefSeq, PubMed]; Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Hklp2 participates in the assembly and stabilization of the bipolar spindle., [RefSeq, PubMed]; KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300. Publication Status: Online-Only, [RefSeq, PubMed]; Kif15 can replace all essential functions of Eg5 in bipolar spindle assembly., [RefSeq, PubMed]; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RV9;Q69YL6;Q96JX7;Q9H280",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0051299 centrosome separation",
        "synthesized_glycan_count": 0,
        "hit_score": 26.0,
        "record_id": "Q9NS87-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NM11-1",
        "uniprot_id": [
            {
                "id": "L37A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NM11",
                "type": "external"
            }
        ],
        "mass": 188393.0,
        "length": 1700,
        "protein_name": "Leucine-rich repeat-containing protein 37A2",
        "gene_name": "LRRC37A2",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 37A2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001006608",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006608",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC37A2",
        "gene_names_refseq": "LRRC37A2; LRRC37",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 37A2",
        "protein_names_refseq": "Leucine-rich repeat-containing protein 37A2; c114 SLIT-like testicular protein; leucine-rich repeat-containing protein 37A2 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:474170)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;32502341;33912179;34357683;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZMC3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A6NM11-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T4B2-1",
        "uniprot_id": [
            {
                "id": "GT253_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T4B2",
                "type": "external"
            }
        ],
        "mass": 67592.0,
        "length": 595,
        "protein_name": "Inactive glycosyltransferase 25 family member 3",
        "gene_name": "CERCAM",
        "organism": "Human",
        "refseq_name": "inactive glycosyltransferase 25 family member 3 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001273689",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273689",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CERCAM; CEECAM1; GLT25D3; KIAA1502",
        "gene_names_refseq": "CEECAM1; CERCAM; GLT25D3",
        "protein_names_uniprotkb": "Inactive glycosyltransferase 25 family member 3; Cerebral endothelial cell adhesion molecule",
        "protein_names_refseq": "cerebral cell adhesion molecule; cerebral endothelial cell adhesion molecule 1; glycosyltransferase 25 domain containing 3; glycosyltransferase 25 family member 3; inactive glycosyltransferase 25 family member 3 isoform b; probable inactive glycosyltransferase 25 family member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51148)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10.1101/2023.09.13.557529;10608765;11237011;19075007;22216269;23481700;26992070;27397612;27600516;28218747;28904123;29786170;30484775;30779550;31530632;31844290;31848261;32157095;32161166;32387766;32897882;32938616;33298915;33592498;33912179;33968037;34105305;34405274;34561969;35051231;35580925;36010968;36241641;36284347;37074911",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro., [UniProtKB, PubMed, PubMed]; The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 829,
        "reported_interactions": 0,
        "missing_score": 9606,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MD00;C4AMA2;Q0VDF3;Q2VPJ4;Q4KMP2;Q5T4B1;Q8N107;Q96EZ5;Q9P226;Q9UMW5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007159 leukocyte cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q5T4B2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000010000.101.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P42681-1",
        "uniprot_id": [
            {
                "id": "TXK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P42681",
                "type": "external"
            }
        ],
        "mass": 61258.0,
        "length": 527,
        "protein_name": "Tyrosine-protein kinase TXK",
        "gene_name": "TXK",
        "organism": "Human",
        "refseq_name": "tyrosine-protein kinase TXK",
        "refseq_ac": [
            {
                "id": "NP_003319",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003319",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TXK; PTK4; RLK",
        "gene_names_refseq": "BTKL; PSCTK5; PTK4; RLK; TKL; TXK",
        "protein_names_uniprotkb": "Tyrosine-protein kinase TXK; 2.7.10.2; Protein-tyrosine kinase 4; Resting lymphocyte kinase",
        "protein_names_refseq": "PTK4 protein tyrosine kinase 4; protein-tyrosine kinase 4; resting lymphocyte kinase; tyrosine-protein kinase TXK",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7294);  (R-HSA-2871809)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10523612;10860980;11015619;11030334;11237011;11353545;11395409;11564877;11859127;12081135;12573241;12975316;17177976;17344846;17502104;18296442;19290923;25593320;26154972;28832583;29493099;29557506;29786170;32157095;32350084;32983136;33968037;34171305;35051231;35580925;39085785;7518558;7951233;8629002;8630736;8631904;8632917;8799126;9813138",
        "class_list": "",
        "function": "Characterization, evolution, and abiotic stress responses of leucine-rich repeat receptor-like protein kinases (LRR-RLK) in Liriodendron chinense. Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14220",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004713 protein tyrosine kinase activity;GO:0004672 protein kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050852 T cell receptor signaling pathway;GO:0001819 positive regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "P42681-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96JK4-1",
        "uniprot_id": [
            {
                "id": "HIPL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96JK4",
                "type": "external"
            }
        ],
        "mass": 86731.0,
        "length": 782,
        "protein_name": "HHIP-like protein 1",
        "gene_name": "HHIPL1",
        "organism": "Human",
        "refseq_name": "HHIP-like protein 1 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001120730",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120730",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HHIPL1; HHIP2; KIAA1822; PRO34761",
        "gene_names_refseq": "HHIPL1; KIAA1822; UNQ9245",
        "protein_names_uniprotkb": "HHIP-like protein 1",
        "protein_names_refseq": "ARAR9245; HHIP-like protein 1 isoform a precursor; HHIP-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84439)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "12975309;16391842;26154972;29655894;30429286;31163988;32938616;36215666",
        "class_list": "",
        "function": "HHIPL1 expression was measured in coronary artery disease-relevant smooth muscle cells., [RefSeq, PubMed]; Results suggest an association of the HHIPL-1 (rs2895811) polymorphism with cardiometabolic parameters and cardiovascular risk factors in Mexican patients with myocardial infarction., [RefSeq, PubMed]; This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUF8;B2RN09;Q6UXX2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96JK4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21266-1",
        "uniprot_id": [
            {
                "id": "GSTM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21266",
                "type": "external"
            }
        ],
        "mass": 26560.0,
        "length": 225,
        "protein_name": "Glutathione S-transferase Mu 3",
        "gene_name": "GSTM3",
        "organism": "Human",
        "refseq_name": "glutathione S-transferase Mu 3",
        "refseq_ac": [
            {
                "id": "NP_000840",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000840",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GSTM3; GST5",
        "gene_names_refseq": "GST5; GSTB; GSTM3-3; GSTM3TV2; GSTM3; GTM3; hGSTM3-3",
        "protein_names_uniprotkb": "Glutathione S-transferase Mu 3; 2.5.1.18; GST class-mu 3; GSTM3-3; hGSTM3-3",
        "protein_names_refseq": "GST class-mu 3; S-(hydroxyalkyl)glutathione lyase M3; brain GST; brain type mu-glutathione S-transferase; epididymis secretory sperm binding protein; glutathione S-alkyltransferase M3; glutathione S-aralkyltransferase M3; glutathione S-aryltransferase M3; glutathione S-transferase M3 (brain); glutathione S-transferase Mu 3; glutathione S-transferase mu 3 (brain); glutathione S-transferase, Mu-3",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); cystic fibrosis (Disease Ontology:DOID:1485); multiple sclerosis (Disease Ontology:DOID:2377); larynx cancer (Disease Ontology:DOID:2596); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); meningioma (Disease Ontology:DOID:3565); macular degeneration (Disease Ontology:DOID:4448); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2947);  (R-HSA-156590)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10329152;10587441;10783391;11327815;11904223;12042665;12211029;12627223;14742434;16081649;16298388;16408927;16548513;18369606;20068231;20083122;20085333;21106529;21668448;22522127;23162467;23301498;2345169;24157827;24397554;27846572;31844290;32157095;32870666;32938616;32983136;33121982;33482859;33592498;3372534;34209254;34229054;35051231;35083852;36010968;36284347;3770744;38228715;38665916;4768551;8182750;8203914;8218382;8331657;8373352;8431482;8703034;8812420;9278457;9551553;9839448;9882431",
        "class_list": "",
        "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers., [UniProtKB, PubMed]; Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]., [RefSeq]; GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4., [RefSeq, PubMed]; Glutathione S-Transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Low GSTM3 expression is associated with poor disease-free survival in resected esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60550;Q96HA3",
        "ec_number_list": [
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "5.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2",
                "type": "external"
            },
            {
                "id": "5.3.99.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "5.3.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-",
                "type": "external"
            },
            {
                "id": "1.20.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "4.4.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0035686 sperm fibrous sheath",
        "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0043627 response to estrogen;GO:0008065 establishment of blood-nerve barrier;GO:0006749 glutathione metabolic process;GO:0018916 nitrobenzene metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "P21266-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01825-1",
        "uniprot_id": [
            {
                "id": "HV459_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01825",
                "type": "external"
            }
        ],
        "mass": 12936.0,
        "length": 116,
        "protein_name": "Immunoglobulin heavy variable 4-59",
        "gene_name": "IGHV4-59",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV4-59",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 4-59; Ig heavy chain V-II region NEWM",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
        "pathway_count": 19,
        "publication_count": 537,
        "publication_id_list": "10026222;10051622;10068651;10072481;1008494;10087012;10219243;10224668;10381560;10395673;10432293;10496324;10498607;10499918;10523831;10531307;10556826;10559936;10579907;10606205;10648173;1067618;10702308;10706702;10724160;10746781;10764623;10770799;10781580;1081164;10838074;10860980;10861086;10878810;10880360;10882101;10917520;10925294;10983984;10995437;11007481;11015619;11030334;11042164;11071869;11090634;11157975;11196644;11207550;11226282;11231582;11256994;11265639;11276226;11278486;11306453;11325957;11329366;11340081;11340169;11340299;11368773;11395409;11425868;11449366;11460167;11489943;11513152;11553796;11556966;11564780;11606584;11694537;11713268;11747816;11749377;11772397;11779189;11804587;11807247;11812992;11829459;11854399;11857637;11858820;11861603;11877257;11901194;11909947;11939578;11955593;11955595;11955599;11994425;12055245;12055636;12070135;12105426;12117970;12181444;12189515;12208882;12213210;12213321;12217391;12235133;12396008;12417718;12453414;12456653;12469115;12473184;12483297;1249422;1252417;12573241;12588680;12660731;12670394;12670955;12743368;12782713;12869549;12975316;1314888;13342742;13472068;1372004;1372019;1374290;1375264;1376928;1386357;14280442;14514672;14529530;14615387;14630197;14676198;14719373;14970179;15000751;15010370;15034010;15040784;15125833;15136729;15155468;15161916;15187135;15187158;15199963;15294978;15304001;15327770;15448162;15452139;1550550;15509800;15528364;15534202;15536084;15541655;15542058;15548136;15580655;15607800;15657136;15681301;15686303;15697213;15721307;15778510;15781451;15800062;15809313;15851719;15864273;15879134;1591491;15947085;1599430;16014749;16046400;16079145;16091383;16115318;16129954;16186825;16189277;16192651;16252004;16258728;16262445;16297198;16339513;16356853;16356856;16380601;16408005;16456001;1646599;16497229;16522641;16546099;16551255;16585556;16641196;16678913;16691243;16702231;16737824;16737840;16754721;16778136;16783819;16831874;16849466;16880808;16893496;16904340;16906149;16921024;16928187;16938345;16978534;16999828;17008602;1702903;17045824;17047224;1705565;17057721;17064312;17099249;17102136;17116209;17135271;17158449;17167768;17172599;17182573;17188549;17202194;17224452;17237375;17308335;17322099;17337780;17379836;17428801;17442946;17452328;17452516;17486119;17496917;17498065;17502104;17505016;17505110;17525755;17540168;17563375;17576170;17580308;17590538;17600130;17615384;17625065;17662961;17845074;17948050;17993265;18006696;18025150;18031695;18037897;18052078;18055229;18070890;18187424;18209062;18234675;18296442;18326500;18391171;18420269;18556779;18593354;18596693;18772140;18818202;18843204;18995841;19124833;19149696;19206206;19249086;19279206;19324878;19359216;19372136;19574218;19592130;19592646;19650691;19741094;19909365;19955216;2011584;20176268;20192804;20223979;20300203;20430887;20685844;20730098;20920479;21037092;21193412;21241660;21408196;21419341;21469132;21653832;21659548;21788512;21800138;21822214;21841309;21877119;21966355;22158414;22180443;22210847;22396535;22401777;22492620;22552008;22798961;22802338;22814904;22922649;2303036;2304550;23487775;23641311;23675550;23695528;23836650;23929856;23945545;24043627;2420889;24272870;24305946;24584101;24600447;2465906;2466593;2474607;24764293;2481448;25200415;2529342;2538457;25703557;25716998;25801024;26002965;26284469;26300885;2806549;2833500;2833705;28425720;28904123;293688;293746;29557506;2956252;2971659;29945920;301546;30201761;31048504;34357683;3500860;36284347;36581221;3848661;3891754;4074707;407927;4098172;4327491;4589993;468991;496916;5135507;6019133;618887;6214588;6219696;6222381;6230668;6238120;6334079;6335036;6454142;6480598;6607952;670886;6849882;6906228;702059;70787;7263686;7287740;7378053;7391570;7391573;7509040;7512959;7516890;7517665;7518558;7521687;7521878;7522622;7524079;7526393;7528218;7528327;7530449;7531291;7538118;7542404;7542572;7561031;7592958;760802;761607;7618087;7687428;7687539;7688784;7690834;7691807;7691959;7706301;7718892;7848918;7855889;7927516;7997270;803528;8071371;814163;8163536;8163559;8166770;8178173;8226994;8228618;8306975;8314844;8327478;8340414;8345200;8424694;8475064;8493579;8495193;8538770;8541526;8611682;8629002;8630736;8631904;8657103;8663278;8673706;8702662;8786315;8799126;8809042;8855948;8862523;8910399;8947047;8986718;8995416;8995445;9000504;9038722;9042338;9050880;9052782;9099726;9162098;9169774;9199344;9235916;9242610;9285412;9295288;9295361;9314552;9314561;9326643;9341187;9382878;9382888;9477973;9480991;9547345;9600938;9601638;9639556;9693095;9697839;9700512;9705280;9705962;971416;9730896;9763524;978134;9799231;9843499;9857068;9883880;9885284;9890995;9973503;9989831",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 475,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0C4DH40;A0A0G2JPU1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 53.8,
        "record_id": "P01825-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P40933-1",
        "uniprot_id": [
            {
                "id": "IL15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P40933",
                "type": "external"
            }
        ],
        "mass": 18086.0,
        "length": 162,
        "protein_name": "Interleukin-15",
        "gene_name": "IL15",
        "organism": "Human",
        "refseq_name": "interleukin-15 isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000576",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000576",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL15",
        "gene_names_refseq": "IL-15; IL15",
        "protein_names_uniprotkb": "Interleukin-15; IL-15",
        "protein_names_refseq": "interleukin-15 isoform 1 preproprotein",
        "tax_id": 9606,
        "disease": "pleurisy (Disease Ontology:DOID:10247); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); listeriosis (Disease Ontology:DOID:11573); pulmonary sarcoidosis (Disease Ontology:DOID:13406); aspergillosis (Disease Ontology:DOID:13564); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); pulmonary fibrosis (Disease Ontology:DOID:3770); pancreatitis (Disease Ontology:DOID:4989); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); lung disease (Disease Ontology:DOID:850); viral infectious disease (Disease Ontology:DOID:934); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3600);  (R-HSA-8983432)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10233906;10358752;12433361;12623850;15039446;15123770;16212621;21167836;23104097;24737791;31844290;32576222;33912179;38446900;38581915;38814240;39078714;39217881;7568001;7641685;8026467;8178155;8530383;8668345;8932977;9126349;9326248;9405632",
        "class_list": "",
        "function": "Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8178155, PubMed:9326248). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (PubMed:9326248). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits (PubMed:10233906, PubMed:23104097, PubMed:8026467). Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (PubMed:7568001). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Elevated IL-15 levels in systemic lupus erythematosus: potential pathogenesis insight and therapeutic target., [RefSeq, PubMed]; HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones. Publication Status: Online-Only, [RefSeq, PubMed]; IL-15 gene mutation as a molecular risk factor in acute lymphoid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies., [RefSeq, PubMed]; Interleukin-15 is a hair follicle immune privilege guardian., [RefSeq, PubMed]; The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "monitoring",
        "glycan_count": 0,
        "disease_count": 19,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNZ2;O00440;O43512;Q495Z8;Q6FGX7;Q93058;Q9UBA3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0005126 cytokine receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome",
        "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0034105 positive regulation of tissue remodeling;GO:0006955 immune response;GO:0007165 signal transduction;GO:0007267 cell-cell signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "P40933-1",
        "record_type": "protein",
        "filter_code": "0100000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9GZX6-1",
        "uniprot_id": [
            {
                "id": "IL22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9GZX6",
                "type": "external"
            }
        ],
        "mass": 20011.0,
        "length": 179,
        "protein_name": "Interleukin-22",
        "gene_name": "IL22",
        "organism": "Human",
        "refseq_name": "interleukin-22 precursor",
        "refseq_ac": [
            {
                "id": "NP_065386",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065386",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL22; ILTIF; PRO10096; ZCYTO18",
        "gene_names_refseq": "IL-21; IL-22; IL-D110; IL-TIF; IL22; ILTIF; TIFIL-23; TIFa; zcyto18",
        "protein_names_uniprotkb": "Interleukin-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-22; IL-TIF",
        "protein_names_refseq": "IL-10-related T-cell-derived inducible factor; cytokine Zcyto18; interleukin-22 precursor",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841); liposarcoma (Disease Ontology:DOID:3382); tuberculosis (Disease Ontology:DOID:399); rhinitis (Disease Ontology:DOID:4483); myocarditis (Disease Ontology:DOID:820)",
        "pathway": " (hsa:50616);  (R-HSA-8854691);  (R-HSA-9725370)",
        "pathway_count": 3,
        "publication_count": 155,
        "publication_id_list": "10216106;10556217;10702393;10706082;10706887;10875937;10934142;10954742;11110708;11163236;11196675;11197690;11280786;11310834;11390453;11390454;11481447;11504915;11564763;11706020;11751994;11850821;11856845;11943732;11988758;12087100;12112524;12185581;12351624;12424201;12469119;12750159;12800156;12920229;12934099;12975309;14580208;14764663;14962911;15120653;15166220;15169778;15178681;15208656;15327950;15340161;15374880;15588951;15895073;15919823;15983417;16153455;16161041;16170336;1662392;16750817;16825495;16871283;16939498;16982608;17086210;17204547;17353907;17416736;17483340;17625570;17878297;18097461;18452557;18593892;18594010;18599299;18669613;18701132;18724359;18830264;18923523;18923524;18923525;18941194;19456272;19457860;19459784;19535621;20454865;20462497;20671117;20966397;21098725;21134980;21164297;21213368;21415216;21494621;21596819;21656749;21838707;21847362;22249260;22327622;22347464;22570254;22658521;22802649;22962576;23104988;23139213;23201355;23239810;23661334;23957430;24060861;24445538;24475247;24496003;24518094;24613930;24736082;25004819;25342631;25393796;25421750;25793261;25813404;25921060;26001147;26059044;26062823;26301689;27133025;27245569;27573755;27874193;28404650;28458652;28659337;28741662;29455642;29557506;29873274;30131584;30692217;31311100;31366041;38728884;38733584;39003443;39231878;39423135;7512451;7543512;7824924;8633037;8830676;9819383",
        "class_list": "",
        "function": "Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed:10875937, PubMed:18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed:25793261, PubMed:31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Expression and diagnostic value of interleukin-22 in rheumatoid arthritis-associated interstitial lung disease., [RefSeq, PubMed]; IL-22 promotes mucin-type O-glycosylation and MATH1[+] cell-mediated amelioration of intestinal inflammation. Erratum:[Cell Rep. 2024 Aug 27;43(8):114643. doi: 10.1016/j.celrep.2024.114643. PMID: 39097926], [RefSeq, PubMed]; Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling., [RefSeq, PubMed]; The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy especially in tuberculous pleurisy. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The role of IL-22 in cancer. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045518 interleukin-22 receptor binding;GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0006953 acute-phase response;GO:0050728 negative regulation of inflammatory response;GO:0051384 response to glucocorticoid",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "Q9GZX6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000100010000.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96CB8-1",
        "uniprot_id": [
            {
                "id": "INT12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96CB8",
                "type": "external"
            }
        ],
        "mass": 48808.0,
        "length": 462,
        "protein_name": "Integrator complex subunit 12",
        "gene_name": "INTS12",
        "organism": "Human",
        "refseq_name": "integrator complex subunit 12",
        "refseq_ac": [
            {
                "id": "NP_001135943",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135943",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "INTS12; PHF22; SBBI22",
        "gene_names_refseq": "INT12; INTS12; PHF22; SBBI22",
        "protein_names_uniprotkb": "Integrator complex subunit 12; Int12; PHD finger protein 22",
        "protein_names_refseq": "PHD finger protein 22; hypothetical nuclear factor SBBI22; integrator complex subunit 12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57117);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10.1101/2023.09.13.557529;10022900;11237011;11856838;12414730;12574128;14701755;1535687;16239144;16308568;16901896;16964243;1739980;18079403;1829677;18452278;18669648;18691976;19413330;19615748;19651622;19667075;20010835;20068231;20332099;20457598;2125285;22137580;22231121;22252320;22441827;22645359;23166507;23186163;23904267;23932780;24097444;24270878;24275569;24714562;24997600;25218447;25576301;25675981;25880248;26728094;26992070;27600516;27846572;28218747;28832583;28834231;29242379;29351928;29437277;2944599;29557506;29632046;30059200;30315122;30833945;31844290;31848261;32157095;32387766;32574038;32938616;32983136;33214551;33912179;33968037;34019948;34087483;34171305;34846842;35051231;35254053;35513511;35561310;35580925;37541260;38570683;38665916;39032490;39534244;39603240;40596516;7715707;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)., [UniProtKB, PubMed, PubMed, PubMed]; INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]., [RefSeq]; Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock, Victor [added]; Tischfield, Jay A [added]], [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC48;Q3B6Z3;Q9HD71",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0032039 integrator complex;GO:0160232 INTAC complex",
        "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "Q96CB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75164-1",
        "uniprot_id": [
            {
                "id": "KDM4A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75164",
                "type": "external"
            }
        ],
        "mass": 120662.0,
        "length": 1064,
        "protein_name": "Lysine-specific demethylase 4A",
        "gene_name": "KDM4A",
        "organism": "Human",
        "refseq_name": "lysine-specific demethylase 4A",
        "refseq_ac": [
            {
                "id": "NP_055478",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055478",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KDM4A; JHDM3A; JMJD2A; JMJD2; KIAA0677",
        "gene_names_refseq": "JHDM3A; JMJD2A; JMJD2; KDM4A; TDRD14A",
        "protein_names_uniprotkb": "Lysine-specific demethylase 4A; 1.14.11.66; 1.14.11.69; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A",
        "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; jmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; lysine-specific demethylase 4A; tudor domain containing 14A",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); stomach carcinoma (Disease Ontology:DOID:5517); alopecia areata (Disease Ontology:DOID:986)",
        "pathway": " (hsa:9682);  (R-HSA-3214842);  (R-HSA-5693565);  (R-HSA-9029569)",
        "pathway_count": 4,
        "publication_count": 217,
        "publication_id_list": "10550055;10724175;10766245;10802669;10858438;10866324;10959836;10973490;11025670;11114888;11149950;11237011;11390408;11500512;11571274;11573085;11604492;11875109;11893489;11927591;11934988;12032151;12150943;12364621;12447390;12454263;12485996;12607003;12607005;12612088;12697768;12773400;12792649;12832489;12890688;14560035;14703507;14764426;15064416;15147902;15201865;15279782;15620353;15927959;16024779;16094384;16150728;16362057;16377563;16415788;16427009;16601153;16603237;16603238;16651405;16677698;16732292;16732293;16738407;17186944;17310255;17320163;17351631;17525332;17525340;17553757;17713478;17848578;17947579;18001824;18001825;18006705;18077395;18443292;18452278;18644861;18669648;18782758;19001859;19092802;19117993;19144645;19176521;19203578;19203579;19234442;19261749;19351884;19481530;19502796;19727073;19782031;19843542;20016603;20023638;20023648;20084082;20129925;20208542;20351172;20457893;20466882;20466885;20494359;20566875;20622853;20622854;20855588;20934997;21187453;21282113;21293379;21310851;21507939;21532585;21694756;21768309;22234877;22373579;22508508;22541735;22589545;22615488;22673513;22908299;22980979;23186163;23481700;23496987;23519696;23790976;24029068;24366607;24667604;24715725;25418920;25576301;26154972;26375851;26741168;26758079;26984517;26992070;27214403;27846572;27862975;27920218;28082258;28212444;28218747;28228285;28514659;28649982;28832583;28834231;28842423;28869506;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29563586;29632046;29632711;29772548;29786170;29789417;30156264;30315122;30410026;30429286;30484775;30779550;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34561969;35051231;35318648;35580925;36284347;37179361;37217939;37870957;37873881;37938771;38818897;38878485;39085849;8944023;9168116;9488723",
        "class_list": "",
        "function": "Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain., [UniProtKB, PubMed]; FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20' (PubMed:16603238, PubMed:26741168, PubMed:21768309). Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues (PubMed:16603238, PubMed:26741168, PubMed:21768309). Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238). Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3) (PubMed:19144645, PubMed:30156264). Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (PubMed:16024779)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; JMJD2A promotes the development of castration-resistant prostate cancer by activating androgen receptor enhancer and inhibiting the cGAS-STING pathway., [RefSeq, PubMed]; JMJD2A selectively represses the expression of the achaete scute-like homologue 2 (ASCL2) gene but not other imprinted genes in the same imprinted locus in HeLa cells, [RefSeq, PubMed]; SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A. Publication Status: Online-Only, [RefSeq, PubMed]; The ability of JMJD2A to associate with retinoblastoma proteins and histone deacetylase 1 implies an important role for this protein in cell proliferation and oncogenesis., [RefSeq, PubMed]; The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma., [RefSeq, PubMed]; The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis., [RefSeq, PubMed]; This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VVB1",
        "ec_number_list": [
            {
                "id": "1.14.11.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66",
                "type": "external"
            },
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "1.14.11.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65",
                "type": "external"
            },
            {
                "id": "1.14.99.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66",
                "type": "external"
            },
            {
                "id": "1.14.11.69",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.1.1.357",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "1.14.11.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79",
                "type": "external"
            },
            {
                "id": "1.14.11.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0032452 histone demethylase activity;GO:0032454 histone H3K9 demethylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin;GO:0005721 pericentric heterochromatin",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0010507 negative regulation of autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 22.0,
        "record_id": "O75164-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4FZB7-1",
        "uniprot_id": [
            {
                "id": "KMT5B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4FZB7",
                "type": "external"
            }
        ],
        "mass": 99188.0,
        "length": 885,
        "protein_name": "Histone-lysine N-methyltransferase KMT5B",
        "gene_name": "KMT5B",
        "organism": "Human",
        "refseq_name": "histone-lysine N-methyltransferase KMT5B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_057112",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057112",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KMT5B; CGI-85; SUV420H1",
        "gene_names_refseq": "CGI-85; CGI85; KMT5B; MRD51; SUV420H1",
        "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5B; 2.1.1.361; 2.1.1.362; Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B; Su(var)4-20 homolog 1; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B",
        "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5B isoform 2; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine (K)-specific methyltransferase 5B; lysine N-methyltransferase 5B; lysine-specific methyltransferase 5B; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 51 (Disease Ontology:DOID:0080232)",
        "pathway": " (hsa:51111);  (R-HSA-3214841)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "10949293;11237011;11401438;11959841;12123582;12130538;12453418;12540855;12670868;14536086;14690610;14992727;15145825;15235609;15964846;16118227;16199523;16292313;16322686;16519522;16682010;16805913;17021013;17500065;17544230;17707229;18172012;18296440;19808676;20068231;20112406;21131967;21196496;21779408;21832073;22099308;22939622;23720823;24396869;25218447;25772364;27600516;27920218;28063628;28114273;28191889;28228285;28832583;29242379;29276005;29393594;29508533;29557506;29632046;29671580;29786170;30379171;30429286;30484775;31092671;31844290;32157095;32265295;32387766;32488085;32502341;32938616;32983136;33141586;33592498;33717175;33968037;33981976;34716350;35331928;35580925;36010968;36897941;37595555;38082550",
        "class_list": "",
        "function": "Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1., [RefSeq, PubMed]; Genome-wide association study identifies susceptibility loci for acute myeloid leukemia. Erratum:[Nat Commun. 2022 Jan 4;13(1):2. doi: 10.1038/s41467-021-27679-6. PMID: 34983928] Publication Status: Online-Only, [RefSeq, PubMed]; Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma., [RefSeq, PubMed]; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis., [RefSeq, PubMed]; Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice., [RefSeq, PubMed]; The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20], [RefSeq, PubMed]; This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MT19;B7WNX7;Q3SX56;Q4V775;Q6P150;Q96E44;Q9BUL0;Q9H022;Q9H2K3;Q9NXV3;Q9Y393",
        "ec_number_list": [
            {
                "id": "2.1.1.362",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362",
                "type": "external"
            },
            {
                "id": "2.1.1.361",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361",
                "type": "external"
            },
            {
                "id": "2.1.1.354",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.355",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0042054 histone methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000779 condensed chromosome, centromeric region;GO:0005694 chromosome",
        "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007517 muscle organ development;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q4FZB7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P25205-1",
        "uniprot_id": [
            {
                "id": "MCM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P25205",
                "type": "external"
            }
        ],
        "mass": 90981.0,
        "length": 808,
        "protein_name": "DNA replication licensing factor MCM3",
        "gene_name": "MCM3",
        "organism": "Human",
        "refseq_name": "DNA replication licensing factor MCM3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001257401",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257401",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCM3",
        "gene_names_refseq": "HCC5; MCM3; P1-MCM3; P1.h; RLFB",
        "protein_names_uniprotkb": "DNA replication licensing factor MCM3; 3.6.4.12; DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102",
        "protein_names_refseq": "DNA polymerase alpha holoenzyme-associated protein P1; DNA replication factor MCM3; DNA replication licensing factor MCM3 isoform 2; DNA replication licensing factor MCM3; MCM3 minichromosome maintenance deficient 3; RLF subunit beta; cervical cancer proto-oncogene 5; hRlf beta subunit; minichromosome maintenance deficient 3; p102; replication licensing factor, beta subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4172);  (R-HSA-176187);  (R-HSA-176974);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-68962);  (R-HSA-69052)",
        "pathway_count": 7,
        "publication_count": 182,
        "publication_id_list": "10051570;10373362;10373557;10518787;10523313;10757793;10777662;10827953;10846177;10859164;10882098;10884341;11095689;11125146;11237011;11248027;11258703;11390642;11562349;11739726;11931757;12045100;12226073;12364596;12399544;12578958;12676583;12676925;12759351;12791985;12963847;14500360;14603323;14605214;14624239;14672932;15190204;15210935;15226314;1549468;15707391;15743907;15833913;16327781;16407120;16824194;16899510;16964243;17081983;17234884;17244605;17296731;17417653;17485488;17487921;18283219;18480045;18524952;18669648;18691976;18991276;19369195;19690332;19896182;20068231;21406692;21965652;22223895;22424782;22967762;23186163;23481700;23603117;23711367;23851460;24366607;24714562;24715725;25231993;25367160;25418920;25505266;25576301;25645385;25810538;25892735;26154972;26222030;26375851;26728094;26811146;26992070;27249176;27846572;27862975;28510447;28832583;28834231;28904123;29242379;29371260;29393594;29493099;29508533;29557506;30069701;30315122;30316783;30397120;30410026;30484775;30524438;31186514;31217245;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32453425;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34193281;34405274;34449552;34509645;34561969;34671420;34694004;34700328;34725712;34782936;34932366;35051231;35083852;35138101;35251023;35318648;35580925;35585232;36010968;36215666;36241641;36284347;36581221;37938771;38665916;39894887;40596516;40914422;7758114;8196638;8265339;8943031;9278511;9278512;9635433;9660782;9712829",
        "class_list": "",
        "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB]; Bioinformatics Analysis Reveals MCM3 as an Important Prognostic Marker in Cervical Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma., [RefSeq, PubMed]; Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWW4;Q92660;Q9BTR3;Q9NUE7",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "2.7.7.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-",
                "type": "external"
            },
            {
                "id": "2.7.7.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity",
        "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:1902975 mitotic DNA replication initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 18.6,
        "record_id": "P25205-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P00387-1",
        "uniprot_id": [
            {
                "id": "NB5R3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P00387",
                "type": "external"
            }
        ],
        "mass": 34235.0,
        "length": 301,
        "protein_name": "NADH-cytochrome b5 reductase 3",
        "gene_name": "CYB5R3",
        "organism": "Human",
        "refseq_name": "NADH-cytochrome b5 reductase 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000389",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000389",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CYB5R3; DIA1",
        "gene_names_refseq": "B5R; CYB5R3; DIA1",
        "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 3; 1.6.2.2; B5R; Cytochrome b5 reductase; Diaphorase-1",
        "protein_names_refseq": "NADH-cytochrome b5 reductase 3 isoform 1; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form; diaphorase-1; mutant NADH-cytochrome b5 reductase",
        "tax_id": 9606,
        "disease": "estrogen-receptor negative breast cancer (Disease Ontology:DOID:0060076); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); methemoglobinemia (Disease Ontology:DOID:10783); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); obesity (Disease Ontology:DOID:9970); methemoglobinemia due to deficiency of methemoglobin reductase (MONDO:MONDO:0009606)",
        "pathway": " (hsa:1727);  (R-HSA-196836);  (R-HSA-211945);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 148,
        "publication_id_list": "10.1101/2023.09.13.557529;10445380;10471399;10556483;10556521;10783391;10807796;10862609;10874300;10945627;11154734;11237011;11396616;11422004;12393396;12725862;12732646;1351198;1400360;15350128;15492766;15502298;15523003;15535985;15622768;15921385;15953014;15970797;16614850;16748235;16765324;1707593;17400359;18254726;18256025;18285471;18318771;18477386;18669648;1898726;19053771;19588076;19608861;19764817;20007405;20177059;2019583;20422440;20542992;20784876;2107882;22700792;22813719;23481700;23616950;23650620;23953689;24423752;24677340;2479590;24900196;2498303;25144769;25255805;25367160;25418920;25425164;25446851;25502872;25576301;25923589;26811146;26992070;27452731;27862975;27920218;28063628;28228285;28832583;28834231;28904123;2897122;29242379;29314611;29393594;29557506;29632046;29786170;30315122;3035541;30429286;31020640;31154438;31217245;31844290;31848261;32152082;32157095;32161166;32171872;32187464;32205870;32210741;32350084;32357974;32387766;32870666;32938616;32983136;33298915;33592498;33968037;34019948;34185709;34357683;34561969;35051231;35064402;35154160;35251023;35318648;35580925;36241641;36284347;3700359;37217939;38353123;38665916;40596516;4063522;6389526;7668255;7718898;7980644;8119939;8315383;8427971;8513896;8692836;8985016;9048929;9169443;9228080;9367528;9639531;9653080;9695975;9886302",
        "class_list": "glycogene",
        "function": "CYB5R3 T117S Genetic Mutation Is Associated With Major Adverse Cardiovascular and Cerebrovascular Events in Black Adults., [RefSeq, PubMed]; Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]., [RefSeq]; Three novel mutations in CYB5R3 gene causing NADH-cytochrome b5 reductase enzyme deficiency leads to recessive congenital methaemoglobinemia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 479,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 9,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AHF2;B7Z7L3;O75675;Q8TDL8;Q8WTS8;Q9UEN4;Q9UEN5;Q9UL55;Q9UL56",
        "ec_number_list": [
            {
                "id": "4.6.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19",
                "type": "external"
            },
            {
                "id": "3.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24",
                "type": "external"
            },
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.2.1.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.21.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.16.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5",
                "type": "external"
            },
            {
                "id": "3.4.16.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            },
            {
                "id": "3.1.6.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "3.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
                "type": "external"
            },
            {
                "id": "3.4.21.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.6.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.4.14.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "1.7.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-",
                "type": "external"
            },
            {
                "id": "6.3.4.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21",
                "type": "external"
            },
            {
                "id": "1.8.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
            },
            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
                "type": "external"
            },
            {
                "id": "3.4.14.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2",
                "type": "external"
            },
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0008015 blood circulation;GO:0006695 cholesterol biosynthetic process;GO:0006809 nitric oxide biosynthetic process;GO:0016126 sterol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "P00387-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86Y07-1",
        "uniprot_id": [
            {
                "id": "VRK2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86Y07",
                "type": "external"
            }
        ],
        "mass": 58141.0,
        "length": 508,
        "protein_name": "Serine/threonine-protein kinase VRK2",
        "gene_name": "VRK2",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase VRK2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001123952",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123952",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VRK2",
        "gene_names_refseq": "VRK2",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase VRK2; 2.7.11.1; Vaccinia-related kinase 2",
        "protein_names_refseq": "serine/threonine-protein kinase VRK2 isoform 1; serine/threonine-protein kinase VRK2; vaccinia related kinase 2; vaccinia virus B1R-related kinase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7444);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013405);  (R-HSA-9013408);  (R-HSA-9013423)",
        "pathway_count": 6,
        "publication_count": 358,
        "publication_id_list": "10.1101/2023.09.13.557529;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10618392;10652265;10699171;10699464;10847683;10873802;10958683;11007481;11058585;11085924;11145705;11149925;11237011;11373293;11396949;11431473;11432776;11584276;11672528;11689693;11704860;11707441;11756552;11773441;11784792;11803464;11804587;11804589;11804590;11864571;11884391;11912491;11919634;11956649;11961559;11967128;12071859;12093360;12096337;12177196;12195014;12221096;12351724;12376551;12432077;12531887;12546821;12547822;12577064;12650940;12665586;12857875;12877655;12923183;14512443;14514689;14645249;1464587;14675773;14718541;15023524;15033976;15064355;15104674;15107133;15133129;15147912;15169870;15302923;15339924;15342493;15485661;15507211;15542837;15579468;15601624;15611138;15728722;15814684;15850391;15858067;15897194;16002401;16081809;16112081;16116428;16184169;16243035;16243036;16339170;16473593;16492808;16495336;16507994;16519628;1660188;16636067;16702231;16704422;16762923;16777452;16777849;16862148;16896804;16914516;16963744;16968698;17027967;17060455;17064668;17077126;17145773;17158234;17196961;17214551;17244649;17269730;17344846;17583407;17599059;17698854;17702745;17709393;17765681;17804252;17916560;17976533;18006505;18045877;18056264;18160138;18191593;18218625;18249095;18286207;18347018;18396277;18426980;18617507;18653540;18662984;18669648;18691976;18697831;18838382;19141289;19269969;19494238;19534724;19581409;19605563;19673492;19713215;19934221;20068231;20400958;20460433;20679435;20679487;20810653;21148482;21151158;21378159;21542010;21565175;21613211;21621533;21730051;21865595;21989057;22004470;22096251;22298643;22407364;22424782;22475431;22608513;22665057;22734669;22970203;23087206;23096567;23186163;23209303;23255595;23288169;23434736;23481700;23572525;23707487;23718289;23757206;23870057;23940355;24086303;24102721;24259668;24335996;24352656;24623723;24659802;24714562;24859002;24933155;24960694;25024229;25211221;25418920;25428919;25505266;25576301;25704760;25721503;25746724;25795300;25862245;25880248;25892735;26016997;26129894;26154972;26529257;26628301;26728094;26811146;26887924;26929215;26992070;27117132;27145964;27216196;27481945;27555588;27566826;27600516;27713499;27806292;27846572;27852748;27920218;28063628;28114311;28196833;28218747;28228285;28356423;28486133;28514659;28832583;28860189;28904123;28947137;29089502;29242379;29358323;29382922;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29776664;29786170;29789417;30315122;30410026;30524438;30779550;30833945;30853411;31154438;31222486;31389670;31844290;31871319;32157095;32161166;32203420;32265295;32357974;32387766;32488085;32502341;32897882;32983136;33691108;33717175;33836029;33912179;33936100;33968037;33981976;34171305;34357683;34932366;35051231;35173553;35318648;35580925;36040810;36241641;37452335;37943248;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8662891;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8945468;8990121;8994827;9013646;9099726;9113980;9252344;9305890;9344656;9438849;9490638;9497316;9582072;9659915;9670022;9705280;9792683;9822598;9822605;9843499;9988689",
        "class_list": "",
        "function": "Data show that TAK1 forms a stable complex with JIP1 and regulates the activation of JNK, which in turn determines the cellular stress response to hypoxia; this activation of TAK1-JIP1-JNK is suppressed by vaccinia-related kinase 2., [RefSeq, PubMed]; Elucidating the interaction of C-terminal domain of Vaccinia-Related Kinase 2A (VRK2A) with B-cell lymphoma-extra Large (Bcl-xL) to decipher its anti-apoptotic role in cancer., [RefSeq, PubMed]; Human VRK2 interacts specifically with EBV BHRF1 and that the interaction is involved in protecting cells from apoptosis, [RefSeq, PubMed]; Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity., [UniProtKB, PubMed]; Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]., [RefSeq]; VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating IKKbeta in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; VRK2 induces p53 stabilization by post-translational modification, largely due to threonine 18 phosphorylation in tumor cell lines., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKL0;D6W5D4;D6W5D6;Q49AK9;Q53EU9;Q53S39;Q53S77;Q53TU1;Q86Y08;Q86Y09;Q86Y10;Q86Y11;Q86Y12;Q8IXI5;Q99987",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "1.3.1.70",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.9.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:2000659 regulation of interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0006974 DNA damage response;GO:0046777 protein autophosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 36.1,
        "record_id": "Q86Y07-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15466-1",
        "uniprot_id": [
            {
                "id": "NR0B2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15466",
                "type": "external"
            }
        ],
        "mass": 28058.0,
        "length": 257,
        "protein_name": "Nuclear receptor subfamily 0 group B member 2",
        "gene_name": "NR0B2",
        "organism": "Human",
        "refseq_name": "nuclear receptor subfamily 0 group B member 2",
        "refseq_ac": [
            {
                "id": "NP_068804",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068804",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NR0B2; SHP",
        "gene_names_refseq": "NR0B2; SHP1; SHP",
        "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 2; Orphan nuclear receptor SHP; Small heterodimer partner",
        "protein_names_refseq": "nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; small heterodimer partner",
        "tax_id": 9606,
        "disease": "alcoholic hepatitis (Disease Ontology:DOID:12351); intrahepatic cholestasis (Disease Ontology:DOID:1852); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:8431);  (R-HSA-383280)",
        "pathway_count": 2,
        "publication_count": 23,
        "publication_id_list": "10235266;10542397;11136233;11865025;14752053;15175151;15723037;15896744;16751179;21262773;22504882;26960196;28128295;28797635;33444783;33781837;35156505;35580925;37226737;39336801;8650544;9603951;9653119",
        "class_list": "",
        "function": "NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database Analysis Combined with Drug-Target Mendelian Randomization. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERalpha via intermolecular interactions., [RefSeq, PubMed]; SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation., [RefSeq, PubMed]; The effectiveness of small heterodimer partner and FGF 19 levels in prediction of perinatal morbidity in intrahepatic cholestasis of pregnancy., [RefSeq, PubMed]; The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease. Review article, [RefSeq, PubMed]; The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:22504882). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:22504882). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F1D8P5;Q5QP36",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding;GO:0042975 peroxisome proliferator activated receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008203 cholesterol metabolic process;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q15466-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30041-1",
        "uniprot_id": [
            {
                "id": "PRDX6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30041",
                "type": "external"
            }
        ],
        "mass": 25035.0,
        "length": 224,
        "protein_name": "Peroxiredoxin-6",
        "gene_name": "PRDX6",
        "organism": "Human",
        "refseq_name": "peroxiredoxin-6",
        "refseq_ac": [
            {
                "id": "NP_004896",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004896",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRDX6; AOP2; KIAA0106",
        "gene_names_refseq": "1-Cys; AOP2; HEL-S-128m; LPCAT-5; NSGPx; PRDX6; PRX; aiPLA2; p29",
        "protein_names_uniprotkb": "Peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 1.11.1.27; 2.3.1.23; 24 kDa protein; 3.1.1.4; Acidic calcium-independent phospholipase A2; Antioxidant protein 2; Glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; Liver 2D page spot 40; Lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; NSGPx; Non-selenium glutathione peroxidase; Red blood cells page spot 12; aiPLA2",
        "protein_names_refseq": "1-Cys PRX; 1-Cys peroxiredoxin; 24 kDa protein; LPC acyltransferase 5; acidic calcium-independent phospholipase A2; antioxidant protein 2; epididymis secretory sperm binding protein Li 128m; glutathione-dependent peroxiredoxin; liver 2D page spot 40; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; peroxiredoxin-6; red blood cells page spot 12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9588);  (R-HSA-3299685);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 171,
        "publication_id_list": "10029572;10514471;10521424;10656833;10833429;10893423;10919671;10982;11018045;11139407;11507097;11518528;11886899;11912930;12059788;12446202;12665801;12829378;1286669;15044467;15046979;15064408;15280035;15317809;15592455;15596429;15927447;16186110;16401067;16615992;1668270;16750198;16880213;17275676;17322306;17519234;1763037;17707404;18358825;18669648;18703498;18767875;18936159;19140803;19188445;19219623;19542232;19608861;19664994;1999334;20068231;20070187;20367259;20690882;2071038;20716133;20919932;21215271;21385867;21393238;21967640;22223895;22493009;22869735;22905912;22910329;23152058;23164639;23186163;23301498;23454490;23455484;23576270;23650620;24714562;25047527;25418920;25502872;25576301;25645385;26154972;26728094;26830860;26992070;27353378;27846572;27862975;28055018;28218747;28832583;28834231;28904123;29242379;29314611;29317506;29508533;29557506;29786170;30315122;30379171;30429286;30524438;31154438;31217245;31844290;31848261;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32870666;32938616;33043033;33141586;33214551;33298915;33592498;33717175;33912179;33968037;34019948;34171305;34357683;34433824;3457020;34725712;34932366;35051231;35083852;35132862;35138101;35251023;3532102;35580925;3619451;36215666;36241641;36361777;3693360;37329238;37386720;37938771;38003466;38506348;38665916;5389100;60;6286671;6961438;7021796;7172448;7487923;807573;8313871;8379940;8428933;8452552;8663465;8692836;8999971;9050990;9295278;9369223;9497358;9587003;9639555;9726962;9923614",
        "class_list": "",
        "function": "An Aboriginal-led consortium approach to chronic disease action for health equity and holistic wellbeing., [RefSeq, PubMed]; Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population., [RefSeq, PubMed]; Expression and clinical role of PRDX6 in lung adenocarcinoma., [RefSeq, PubMed]; Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration. Publication Status: Online-Only, [RefSeq, PubMed]; Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]., [RefSeq]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8JZY7;P32077;Q5TAH4;Q5ZEZ8",
        "ec_number_list": [
            {
                "id": "4.6.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19",
                "type": "external"
            },
            {
                "id": "3.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9",
                "type": "external"
            },
            {
                "id": "1.16.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.2.1.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.21.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.16.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5",
                "type": "external"
            },
            {
                "id": "3.4.16.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            },
            {
                "id": "3.1.6.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "3.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
                "type": "external"
            },
            {
                "id": "3.4.21.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.6.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.4.14.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.3.1.121",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.n6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6",
                "type": "external"
            },
            {
                "id": "2.3.1.n7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7",
                "type": "external"
            },
            {
                "id": "6.3.4.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            },
            {
                "id": "1.8.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
                "type": "external"
            },
            {
                "id": "3.4.14.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2",
                "type": "external"
            },
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0045296 cadherin binding;GO:0004623 phospholipase A2 activity;GO:0051920 peroxiredoxin activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006979 response to oxidative stress;GO:0046475 glycerophospholipid catabolic process;GO:0045454 cell redox homeostasis;GO:0042744 hydrogen peroxide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "P30041-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43502-1",
        "uniprot_id": [
            {
                "id": "RA51C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43502",
                "type": "external"
            }
        ],
        "mass": 42190.0,
        "length": 376,
        "protein_name": "DNA repair protein RAD51 homolog 3",
        "gene_name": "RAD51C",
        "organism": "Human",
        "refseq_name": "DNA repair protein RAD51 homolog 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_002867",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002867",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAD51C; RAD51L2",
        "gene_names_refseq": "BROVCA3; FANCO; R51H3; RAD51C; RAD51L2",
        "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 3; R51H3; RAD51 homolog C; RAD51-like protein 2",
        "protein_names_refseq": "DNA repair protein RAD51 homolog 3 isoform 2; DNA repair protein RAD51 homolog 3; RAD51-like protein 2; yeast RAD51 homolog 3",
        "tax_id": 9606,
        "disease": "Fanconi anemia complementation group O (Disease Ontology:DOID:0111096); Fanconi anemia (Disease Ontology:DOID:13636); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683); breast-ovarian cancer, familial, susceptibility to, 3 (MONDO:MONDO:0013253)",
        "pathway": " (hsa:5889);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693568);  (R-HSA-5693579);  (R-HSA-5693616);  (R-HSA-912446);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709603);  (R-HSA-983231)",
        "pathway_count": 13,
        "publication_count": 213,
        "publication_id_list": "10029069;10373512;10438626;10562567;10570174;10728666;10733923;10734115;10801132;10856253;10928988;11006276;11042108;11062261;11237011;11242053;11292842;11459987;11744692;11751635;11751636;11832208;11842112;11842113;11895428;11950885;12032298;12134158;12228710;12427746;12686547;12721304;12912992;12966089;14527420;14704354;14716019;15020713;15164066;15247287;15304223;15359272;15665856;15703751;15710388;15916957;16054028;16123081;16215984;16292313;1630448;16322221;16337601;16395335;16793542;17027967;17114795;17196961;17200668;17200671;17200672;17289582;17420451;17541404;17965729;17977839;17981954;17996710;17996711;18256600;18317453;18535008;18957201;19074197;19268590;19293402;19369211;19451272;19584259;19596236;19609323;19783859;19941829;20044539;20044541;20062530;20207730;20400963;20400964;20413593;20530532;20627800;20729832;20729858;20729859;20818382;20871615;20871616;20965415;21520333;218813;21965664;21990120;22194698;22593209;22645308;23108668;23149936;23186163;23509288;23686288;23731732;23754376;23810717;24005041;24013206;24076221;24141787;24371268;24485656;24509834;24831703;25418920;25576301;25645385;25880248;26145171;26154972;26375851;26811146;26845023;26929215;26992070;27846572;27899578;27920218;28063628;28089683;28158555;28218747;28228285;28240985;28319063;28514659;28832583;28855257;28904123;29165669;29237092;29242379;29393594;29437277;29493099;29608566;29632046;29930882;30289697;30311374;30315122;30410026;30779550;31217245;31222486;31530632;31586400;31636395;31757951;31844290;31848261;32157095;32161166;32357974;32387766;32502341;32732220;32938616;32983136;33195396;33298915;33592498;33691108;33717175;33936100;33968037;33978741;33981976;34087483;3409321;34171305;34440403;34509645;34932366;35849344;36010968;36215666;36241641;36284347;38330859;8662638;8816476;8929543;9008167;9065479;9230307;9311981;9326583;9331217;9422515;9450758;9469824;9781043;9826763;9927674",
        "class_list": "",
        "function": "Biallelic germline mutations in a RAD51 paralog are associated with an FA-like syndrome [case report], [RefSeq, PubMed]; Concluded that the RAD51 paralogs are involved in Holliday junction processing in human cells, [RefSeq, PubMed]; Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]; Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43503;Q3B783",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0140664 ATP-dependent DNA damage sensor activity",
        "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0033065 Rad51C-XRCC3 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000707 meiotic DNA recombinase assembly;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0000724 double-strand break repair via homologous recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 21.6,
        "record_id": "O43502-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13105-1",
        "uniprot_id": [
            {
                "id": "ZBT17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13105",
                "type": "external"
            }
        ],
        "mass": 87928.0,
        "length": 803,
        "protein_name": "Zinc finger and BTB domain-containing protein 17",
        "gene_name": "ZBTB17",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 17 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001229813",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229813",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZBTB17; MIZ1; ZNF151; ZNF60",
        "gene_names_refseq": "MIZ-1; ZBTB17; ZNF151; ZNF60; pHZ-67",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 17; Miz-1; Myc-interacting zinc finger protein 1; Zinc finger protein 151; Zinc finger protein 60",
        "protein_names_refseq": "Myc-interacting Zn finger protein-1; zinc finger and BTB domain-containing protein 17 isoform 1; zinc finger and BTB domain-containing protein 17; zinc finger protein 151 (pHZ-67); zinc finger protein 60",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7709);  (R-HSA-381038)",
        "pathway_count": 2,
        "publication_count": 77,
        "publication_id_list": "10601334;10827079;11237011;12204115;12244100;12545156;14739298;1505991;15095404;15466936;16142238;16461360;16539657;17880999;18452278;18664523;19164764;21282569;23186163;23481700;24715725;25245946;25505266;25576301;25645385;26154972;26811146;26992070;27846572;28904123;29493099;29557506;30315122;30429286;30779550;30833945;31154438;31222486;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33141586;33298915;33592498;33717175;33981976;34087483;34145038;34171305;34211107;34305888;34932366;35051231;35580925;36284347;36538983;37040844;37217939;38842567;7557990;7590364;8666242;9037597;9308237;9312026;9450183;9473480",
        "class_list": "",
        "function": "A TNFalpha/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis., [RefSeq, PubMed]; Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1. Publication Status: Online-Only, [RefSeq, PubMed]; Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients., [RefSeq, PubMed]; MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma., [RefSeq, PubMed]; Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10., [RefSeq, PubMed]; This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV07;B4DXB4;B7ZLQ9;F5H411;Q15932;Q5JYB2;Q9NUC9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002682 regulation of immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q13105-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N3Z3-1",
        "uniprot_id": [
            {
                "id": "GTPB8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N3Z3",
                "type": "external"
            }
        ],
        "mass": 32147.0,
        "length": 284,
        "protein_name": "GTP-binding protein 8",
        "gene_name": "GTPBP8",
        "organism": "Human",
        "refseq_name": "GTP-binding protein 8 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_054889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTPBP8",
        "gene_names_refseq": "GTPBP8; HSPC135; MRX8",
        "protein_names_uniprotkb": "GTP-binding protein 8",
        "protein_names_refseq": "GTP binding protein 8 (putative); GTP-binding protein 8 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29083)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;19664994;20877624;26375851;28228285;28904123;30484775;31844290;32157095;32502341;33298915;33392160;33936100;33968037;33981976;34171305;35051231;36241641;38587461",
        "class_list": "",
        "function": "GTPBP8 modulates mitochondrial fission through a Drp1-dependent process., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NE99;A6NN11;A8K0P6;Q5I0Y4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003924 GTPase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8N3Z3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23229-1",
        "uniprot_id": [
            {
                "id": "ITA6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23229",
                "type": "external"
            }
        ],
        "mass": 126606.0,
        "length": 1130,
        "protein_name": "Integrin alpha-6",
        "gene_name": "ITGA6",
        "organism": "Human",
        "refseq_name": "integrin alpha-6 isoform b preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000201",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000201",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ITGA6",
        "gene_names_refseq": "CD49f; ITGA6A; ITGA6B; ITGA6; JEB6; VLA-6",
        "protein_names_uniprotkb": "Integrin alpha-6; CD49 antigen-like family member F; VLA-6",
        "protein_names_refseq": "CD49 antigen-like family member F; integrin alpha-6 isoform b preproprotein; integrin alpha6B; integrin, alpha 6; very late activation protein 6",
        "tax_id": 9606,
        "disease": "junctional epidermolysis bullosa with pyloric atresia (Disease Ontology:DOID:0060733); junctional epidermolysis bullosa Herlitz type (Disease Ontology:DOID:0060737); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); epidermolysis bullosa, junctional 6, with pyloric atresia (MONDO:MONDO:0859233)",
        "pathway": " (hsa:3655);  (R-HSA-2022090);  (R-HSA-210991);  (R-HSA-216083);  (R-HSA-3000157);  (R-HSA-3000170);  (R-HSA-446107);  (R-HSA-9725554);  (R-HSA-9927418);  (R-HSA-9927426);  (R-HSA-9927432);  (R-HSA-9938206)",
        "pathway_count": 12,
        "publication_count": 211,
        "publication_id_list": "37268159;10.1101/2023.09.13.557529;10209034;10366422;10438935;10543983;10593924;10596943;10605720;10637308;10640428;10673366;10713152;10811134;10811835;10880960;10921872;10966814;10982388;11054877;11158588;11237011;11359780;11518510;11572855;11713259;11719518;11943775;11964076;11980922;12067728;12237301;12482924;12496264;12558975;12585966;12624109;12682293;12802069;12807887;12975610;1400327;14602708;14681059;14707126;1476731;14976204;15023541;15140226;15234001;15240572;15265795;15330449;15345499;15383545;15466886;15479743;15556625;15557282;15611341;15675955;15713743;15780751;15837520;1588291;15899827;15901826;15946952;16002701;16051604;16239428;16260747;16263699;16297201;16413178;16581764;16731529;16754661;16754960;16933105;16945929;17303120;17314405;17330888;17339034;17968485;17996943;18710925;18775695;19159218;19242489;1946438;19502598;1953640;19693541;1976638;19924134;20033473;2010551;20682778;20705068;2070796;22314500;22351760;22493504;22539938;22735594;22884367;2307289;23090970;23283814;23374253;23629652;24190977;24715725;24794495;2542022;25576301;25645385;26154972;26340985;2649503;26992070;27607025;27726376;27862975;28832583;28873464;29242379;29331515;29393594;29493099;29557506;2963012;29632711;29741879;29786170;29789417;30429286;30524438;30779550;30905808;31222486;31399284;31844290;32157095;32387766;32488085;32897882;32938616;32983136;33214551;33465208;33537174;33592498;33912179;33968037;33981976;34019948;34078123;34185709;34509645;35051231;35154160;35318648;35580925;35835740;36241641;36284347;37074911;37217939;37340703;37938771;38369001;38641311;38665916;38680094;3997977;40596516;40914422;41018975;7505120;7525578;7541634;7542249;7559467;7583007;7681434;7685013;8118028;8207089;8253814;8344274;8360143;8496190;8560266;8609172;8798654;8838667;8910476;9008168;9115237;9185503;9245798;9251239;9360995;9443892;9565552;9645947;9856810;9858236",
        "class_list": "",
        "function": "Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling., [UniProtKB, UniProtKB]; Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate ITGA6 expression in liver hepatocellular carcinoma. Erratum:[Cancer Sci. 2025 Oct;116(10):2911. doi: 10.1111/cas.70155. PMID: 40682304], [RefSeq, PubMed]; M6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways., [RefSeq, PubMed]; RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination., [RefSeq, PubMed]; TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin alpha6. Publication Status: Online-Only, [RefSeq, PubMed]; The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 10,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 10,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 10,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 84,
        "disease_count": 6,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMU9;B4DG69;B4DKB8;C4AM96;G5E9H1;Q08443;Q0MRC7;Q14646;Q16508;Q53RX7;Q59HB7;Q86VL6;Q9UCT1;Q9UN03",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038132 neuregulin binding;GO:0046872 metal ion binding;GO:0045296 cadherin binding;GO:0038023 signaling receptor activity;GO:0031994 insulin-like growth factor I binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0034676 integrin alpha6-beta4 complex;GO:0034675 integrin alpha6-beta1 complex",
        "go_biological_process": "GO:0007044 cell-substrate junction assembly;GO:0007229 integrin-mediated signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0030335 positive regulation of cell migration;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 30.8,
        "record_id": "P23229-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BVI0-1",
        "uniprot_id": [
            {
                "id": "PHF20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BVI0",
                "type": "external"
            }
        ],
        "mass": 115386.0,
        "length": 1012,
        "protein_name": "PHD finger protein 20",
        "gene_name": "PHF20",
        "organism": "Human",
        "refseq_name": "PHD finger protein 20",
        "refseq_ac": [
            {
                "id": "NP_057520",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057520",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF20; C20orf104; GLEA2; HCA58; NZF; TZP",
        "gene_names_refseq": "C20orf104; GLEA2; HCA58; NZF; PHF20; TDRD20A; TZP",
        "protein_names_uniprotkb": "PHD finger protein 20; Glioma-expressed antigen 2; Hepatocellular carcinoma-associated antigen 58; Novel zinc finger protein; Transcription factor TZP",
        "protein_names_refseq": "PHD finger protein 20; glioma-expressed antigen 2; hepatocellular carcinoma-associated antigen 58; novel zinc finger protein; transcription factor TZP; tudor domain containing 20A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51230);  (R-HSA-3214847);  (R-HSA-6804757);  (R-HSA-6804759);  (R-HSA-69541);  (R-HSA-9772755)",
        "pathway_count": 6,
        "publication_count": 192,
        "publication_id_list": "10329733;10608892;10722742;10786633;10821277;10980695;10980696;11237011;11359766;11504915;11684014;11703362;11923872;11983168;12097419;12203124;12393701;12482972;12494467;12524540;12670868;12800201;14507994;14636557;14729977;14992727;15053880;15199122;15313887;1535557;15598651;15788536;15906353;15916963;15960975;1614537;16163388;16227571;16239140;16382142;16387653;16402859;16474402;16829959;16845383;16878130;16892064;17121812;17145718;17355966;17500065;17612494;17671196;17719541;17925232;17998332;18275817;18381289;18598942;18623064;18669648;18676979;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19187765;19303885;19556245;19608861;19690332;19756449;19816404;19838211;20018852;20068231;20075864;20438709;20575550;20713061;20716525;20961854;21106533;21124902;21131905;21135039;21220120;21406692;21730132;21730163;21986495;22266653;22327296;22334668;22449972;22538442;22652693;22665483;22864287;22975685;23186163;23452852;23481700;23508102;23995757;24244196;24368734;24680668;24714389;24715725;25356872;25561738;25576301;25593305;25645385;25880248;26154972;26324722;26886794;26992070;27563068;27698142;27760318;27846572;27920218;28182322;28218747;28228285;28398509;28649982;28832583;28834231;28904123;29138278;29242379;29393594;29437277;29452418;29508533;29557506;29632711;29786170;29897600;29937342;30315122;30379171;30410026;31217245;31400120;31485071;31544921;31844290;32157095;32161166;32357974;32387766;32502341;32938616;32983136;33123756;33141586;33298915;33657400;33912179;33936100;33968037;33982773;34012049;34171305;34211107;34933446;35033534;35051231;35190547;35318648;35439434;35979628;36010968;36284347;7686617;7784084;7957050;8319905;8479525;8887688;8954786;9427644;9558366;9880483",
        "class_list": "",
        "function": "Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage., [UniProtKB, PubMed, PubMed]; N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation., [RefSeq, PubMed]; PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4pSTAT3MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma., [RefSeq, PubMed]; PHF20 interacts with poly(ADP-ribose) polymerase 1 (PARP1) and directly binds to promoter regions of octamer-binding transcription factor 4 (OCT4) and sex determining region Y-box 2 (SOX2) to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit (H3K4me3)., [RefSeq, PubMed]; Survival of patients with GLEA2 antibodies was increased to 17.4 months and for patients with PHF3 antibodies to 14.7 months, as compared to 7.2 months for patients without GLEA2 or PHF3 antibodies in glioblastoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E235;B2RB56;E1P5S3;Q566Q2;Q5JWY9;Q66K49;Q9BWV4;Q9BXA3;Q9BZW3;Q9H421;Q9H4J6;Q9NZ22",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0071339 MLL1 complex;GO:0000123 histone acetyltransferase complex;GO:0044545 NSL complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 19.5,
        "record_id": "Q9BVI0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2KJY2-1",
        "uniprot_id": [
            {
                "id": "KI26B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2KJY2",
                "type": "external"
            }
        ],
        "mass": 223883.0,
        "length": 2108,
        "protein_name": "Kinesin-like protein KIF26B",
        "gene_name": "KIF26B",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF26B",
        "refseq_ac": [
            {
                "id": "NP_060482",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060482",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF26B",
        "gene_names_refseq": "KIF26B",
        "protein_names_uniprotkb": "Kinesin-like protein KIF26B",
        "protein_names_refseq": "kinesin-like protein KIF26B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55083);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 3,
        "publication_count": 143,
        "publication_id_list": "10052452;10318838;10445031;10559959;10761932;10921873;11172815;11237011;11493604;11689559;11703931;11726511;11739780;11748249;11782313;12047556;12070132;12368902;1406973;14504276;14654841;15029241;15037235;15272311;15326200;15616190;15632110;15813748;16030262;1607388;16262723;1631136;16571679;16633337;1680566;16912714;16926190;16940185;17081983;17113389;17253781;17346968;17360540;17429068;17451557;17538014;17760859;17927562;17956946;18182008;18287528;18342609;18524849;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1957170;19631211;19758564;20005805;20136777;20357002;20427317;20462495;20534429;20637885;21219331;2142332;21550981;21689688;21844168;22013193;22094269;22299025;22304919;23396477;23481700;23585914;24715725;2521221;2522352;25364732;25418920;25436559;25492864;25576301;25652119;25892735;26992070;27846572;28581513;28832583;28904123;29053796;29242379;29557506;29769354;31154438;31217245;3130248;3134048;31530632;31844290;32161166;32983136;33592498;35359341;36284347;36417404;37436127;37938771;38253038;38380081;38855156;38926114;7528108;7539720;7822426;7844144;7929562;8001155;8128252;8132710;8221884;8253837;8505331;8548803;8599929;8602245;8620540;9114004;9177194;9244307;9288971;9405360;9751720;9990005",
        "class_list": "",
        "function": "Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity)., [UniProtKB]; High expression of KIF26B in breast cancer associates with poor prognosis. Erratum:[PLoS One. 2013;8(6). doi:10.1371/annotation/f7a306c2-3de5-4b59-9825-09e4cbc884bf] Publication Status: Online-Only, [RefSeq, PubMed]; Identification of KIF26B as a Tumor Marker for Oral Squamous Cell Carcinoma., [RefSeq, PubMed]; KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; KIF26B plays an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for CRC. Publication Status: Online-Only, [RefSeq, PubMed]; KIF26B, a novel oncogene regulated by miR-372, promotes proliferation and metastasis through the VEGF pathway in gastric cancer Erratum:[Oncogene. 2022 Apr;41(17):2528. doi: 10.1038/s41388-022-02268-z. PMID: 35322198], [RefSeq, PubMed]; Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis., [RefSeq, PubMed]; Noncoding RNAs-based high KIF26B expression correlates with poor prognosis and tumor immune infiltration in colon cancer., [RefSeq, PubMed]; The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]., [RefSeq]; Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 81,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZQR9;Q6ZUZ0;Q8IUN3;Q8IVR1;Q9NWB4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule",
        "go_biological_process": "GO:0072092 ureteric bud invasion;GO:0007018 microtubule-based movement;GO:0048731 system development",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "Q2KJY2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92839-1",
        "uniprot_id": [
            {
                "id": "HYAS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92839",
                "type": "external"
            }
        ],
        "mass": 64704.0,
        "length": 577,
        "protein_name": "Hyaluronan synthase 1",
        "gene_name": "HAS1",
        "organism": "Human",
        "refseq_name": "hyaluronan synthase 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001284365",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284365",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAS1; HAS",
        "gene_names_refseq": "HAS1; HAS",
        "protein_names_uniprotkb": "Hyaluronan synthase 1; 2.4.1.212; HA synthase 1; HuHAS1; Hyaluronate synthase 1; Hyaluronic acid synthase 1",
        "protein_names_refseq": "HA synthase 1; hyaluronan synthase 1 isoform 2; hyaluronate synthase 1; hyaluronic acid synthase 1",
        "tax_id": 9606,
        "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:3036);  (R-HSA-2142845)",
        "pathway_count": 2,
        "publication_count": 20,
        "publication_id_list": "10037799;11237011;1426053;15208308;1703543;17145755;17540771;18434317;24847057;33803805;33908161;33921242;34455221;38862513;8651928;8798477;8798544;8890751;9083017;9601098",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential for the synthesis of hyaluronan, a major component of most extracellular matrices that has a structural role in tissue architecture and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]; Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent., [RefSeq, PubMed]; Regulation of hyaluronan production by beta2 adrenergic receptor signaling., [RefSeq, PubMed]; Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 104,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3V1S7;Q14470;Q9NS49",
        "ec_number_list": [
            {
                "id": "2.4.1.212",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0007155 cell adhesion;GO:0006024 glycosaminoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q92839-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13261-1",
        "uniprot_id": [
            {
                "id": "I15RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13261",
                "type": "external"
            }
        ],
        "mass": 28233.0,
        "length": 267,
        "protein_name": "Interleukin-15 receptor subunit alpha",
        "gene_name": "IL15RA",
        "organism": "Human",
        "refseq_name": "interleukin-15 receptor subunit alpha isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001230468",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230468",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL15RA",
        "gene_names_refseq": "CD215; IL15RA",
        "protein_names_uniprotkb": "Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA",
        "protein_names_refseq": "interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha isoform 3",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:3601);  (R-HSA-8983432)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "10.1074/mcp.M114.046862;10358752;10480910;11237011;11714793;12114302;12433361;12623850;15039446;15123770;15265897;16212621;16377614;17643103;21289315;24737791;25576301;25813380;28832583;28904123;29242379;29786170;31217245;31611695;31844290;32350084;32387766;32793194;32897882;32938616;32983136;33177736;33732245;34509645;35051231;35251023;35580925;35857215;36284347;36607223;37217939;7568001;7641685;8530383;9126349",
        "class_list": "",
        "function": "Does not bind IL15., [UniProtKB, PubMed]; High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity. Publication Status: Online-Only, [RefSeq, PubMed]; MiRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics., [RefSeq, PubMed]; RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population., [RefSeq, PubMed]; Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15alpha receptor complex. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]., [RefSeq]; Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2C2;Q3B769;Q5JVA1;Q5JVA2;Q5JVA4;Q6B0J2;Q7LDR4;Q7Z609",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004896 cytokine receptor activity;GO:0042010 interleukin-15 receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0031667 response to nutrient levels;GO:0010977 negative regulation of neuron projection development;GO:0050766 positive regulation of phagocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q13261-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BWG4-1",
        "uniprot_id": [
            {
                "id": "SSBP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BWG4",
                "type": "external"
            }
        ],
        "mass": 39388.0,
        "length": 385,
        "protein_name": "Single-stranded DNA-binding protein 4",
        "gene_name": "SSBP4",
        "organism": "Human",
        "refseq_name": "single-stranded DNA-binding protein 4 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001009998",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009998",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SSBP4",
        "gene_names_refseq": "SSBP4",
        "protein_names_uniprotkb": "Single-stranded DNA-binding protein 4",
        "protein_names_refseq": "single-stranded DNA-binding protein 4 isoform b",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (hsa:170463)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "11237011;12079286;15345747;18220336;18669648;19413330;19651622;19690332;19913121;20068231;20628086;23186163;24715725;25505266;26154972;28832583;28904123;29242379;29437277;29557506;29671580;30410026;31217245;31844290;32157095;32357974;32387766;32938616;32983136;33298915;33912179;33968037;34509645;35051231;35254053",
        "class_list": "",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BWW5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003697 single-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q9BWG4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2N7-1",
        "uniprot_id": [
            {
                "id": "HIF3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2N7",
                "type": "external"
            }
        ],
        "mass": 72433.0,
        "length": 669,
        "protein_name": "Hypoxia-inducible factor 3-alpha",
        "gene_name": "HIF3A",
        "organism": "Human",
        "refseq_name": "hypoxia-inducible factor 3-alpha isoform b",
        "refseq_ac": [
            {
                "id": "NP_071907",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071907",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HIF3A; BHLHE17; MOP7; PASD7",
        "gene_names_refseq": "HIF-3A; HIF3-alpha-1; HIF3A; IPAS; MOP7; PASD7; bHLHe17",
        "protein_names_uniprotkb": "Hypoxia-inducible factor 3-alpha; Basic-helix-loop-helix-PAS protein MOP7; Class E basic helix-loop-helix protein 17; HIF-3-alpha; HIF3-alpha-1; HIF3-alpha; IPAS; Inhibitory PAS domain protein; Member of PAS protein 7; PAS domain-containing protein 7; bHLHe17",
        "protein_names_refseq": "PAS domain-containing protein 7; basic-helix-loop-helix-PAS protein MOP7; class E basic helix-loop-helix protein 17; hypoxia inducible factor 3 alpha subunit; hypoxia-inducible factor 3-alpha isoform b; inhibitory PAS domain protein; member of PAS protein 7",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:64344);  (R-HSA-1234176);  (R-HSA-452723);  (R-HSA-8951664)",
        "pathway_count": 4,
        "publication_count": 196,
        "publication_id_list": "10535940;10597293;10811609;10823831;10878807;10944113;10973499;11024059;11069780;11237011;11259415;11292861;11292862;11358837;11454738;11504942;11573933;11585840;11598268;11733065;11961546;12101228;12186903;12351678;12504025;12504026;12526791;12538644;12609982;12615973;12682069;12759363;12787505;12788921;12816948;12821933;12912907;14688391;14690597;14757770;15108323;15247232;15277698;15282312;15342930;15361859;15367669;15474027;15493035;15513931;15537541;15572695;15574592;15582778;15601839;15625129;15652483;15652751;15688063;15694336;15695770;15743839;15799966;15860457;15983365;15987702;15988017;16126907;16153702;16171779;16182248;16401342;16547496;16647857;16707496;16738327;16775626;16790436;16943200;16978057;17068183;17081101;17132228;17182618;17183367;17204602;17220875;17267691;17332328;17434750;17497243;17506876;17567999;17572666;17628018;17785452;17998805;18029452;18035408;18093314;18184961;18206966;18212089;18337469;18775313;18776931;18805092;18824471;18826954;18851830;18926707;19151334;19208626;19250909;19321346;19489980;19522013;19604364;19617556;19688839;19694616;19748355;19755485;19829295;19966271;20027182;20416395;20505756;20505821;20837710;20953172;21069422;21335549;21447816;21463634;21630377;21778237;21863050;21924763;21940857;22210884;22215994;22286099;22306028;22327294;22466964;22537386;22959436;22988117;23178592;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23827706;23827708;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25469497;25531226;26344709;26460955;26632597;26906416;27030794;27222660;27551449;27565346;28115426;29153394;30610225;32005965;32284348;33444648;35051231;36277475;36522211;36708442;39456823;9000051;9122164;9790970;9887101;9891082",
        "class_list": "",
        "function": "Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p/HIF3A., [RefSeq, PubMed]; Findings suggest that HIF-3alpha, as a member of the HIF system, is complementary rather than redundant to HIF-1alpha induction in protection against hypoxic damage in alveolar epithelial cells., [RefSeq, PubMed]; HIF-3alpha-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop. Publication Status: Online-Only, [RefSeq, PubMed]; Hypoxia Inducible Factors (HIF1alpha and HIF3alpha) are differentially methylated in preeclampsia placentae and are associated with birth outcomes., [RefSeq, PubMed]; Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments showed that this induction is mediated specifically by HIF-1 and not by HIF-2., [RefSeq, PubMed]; IPAS1 and IPAS2 inhibit angiogenesis by binding to and inhibiting HIF-1alpha and HIF-1beta., [RefSeq, PubMed]; Multiple splice variants of locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex, [RefSeq, PubMed]; Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and HIF3A in Human Colostrum Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]., [RefSeq]; The splice isoform HIF-3alpha4 inhibits transcription of VEGF and GLUT1 by binding to and inhibiting HIF-1alpha and HIF-1beta., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0M185;B4DNA2;I6L988;Q58A43;Q66K72;Q8WXA1;Q96K34;Q9H7Z9;Q9HAI2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0032364 intracellular oxygen homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 19.7,
        "record_id": "Q9Y2N7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23588-1",
        "uniprot_id": [
            {
                "id": "IF4B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23588",
                "type": "external"
            }
        ],
        "mass": 69151.0,
        "length": 611,
        "protein_name": "Eukaryotic translation initiation factor 4B",
        "gene_name": "EIF4B",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 4B isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001317583",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317583",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EIF4B",
        "gene_names_refseq": "EIF-4B; EIF4B; PRO1843",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4B; eIF-4B",
        "protein_names_refseq": "eukaryotic translation initiation factor 4B isoform 3",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); basal ganglia calcification (Disease Ontology:DOID:0060230); infantile myofibromatosis 1 (Disease Ontology:DOID:0070666); infantile myofibromatosis (Disease Ontology:DOID:0080109); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); extrahepatic cholestasis (Disease Ontology:DOID:13619); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); myeloproliferative neoplasm (Disease Ontology:DOID:2226); Leydig cell tumor (Disease Ontology:DOID:2696); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); choriocarcinoma (Disease Ontology:DOID:3594); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); nephrolithiasis (Disease Ontology:DOID:585); severe nonproliferative diabetic retinopathy (Disease Ontology:DOID:8946)",
        "pathway": " (hsa:1975);  (R-HSA-156827);  (R-HSA-166208);  (R-HSA-429947);  (R-HSA-72649);  (R-HSA-72662);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-9820841);  (R-HSA-9820865)",
        "pathway_count": 10,
        "publication_count": 201,
        "publication_id_list": "10364207;10637334;10654941;10659855;10882133;1095581;11018020;11237011;11283721;11875071;11889047;12150926;12588972;12742462;1355481;14567916;14583602;14749774;14978097;15071500;15104674;15302935;15314020;15345747;15475613;15809305;16075062;16141059;16284618;16763566;16964243;17052452;17081983;1715244;17234686;17245413;17287340;17322306;17389395;17595167;17924679;18212344;18452278;1856230;18625844;18669648;18707149;18767875;18836482;19239894;19413330;19415658;19558367;19608861;19651622;19664994;19664995;19690332;20068231;20166139;21248752;21406692;21602892;21635931;21993680;22750809;23186163;2390971;24275569;24366607;24715725;24777602;25332164;25480299;25502872;25505266;25576301;25645385;25810538;25880248;26154972;26768311;26992070;27028868;27528663;27543614;27600516;27846572;27862975;27920218;28228285;28514659;28832583;28834231;28904123;291969;29242379;29351928;29493099;29508533;29557506;29602958;29632046;29632711;29786170;29789417;30059200;30285764;30315122;30379171;30484775;30583073;30620550;30626607;30779550;30784271;31106142;31154438;31217245;31373491;31492838;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32387766;32488085;32502341;32502391;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33592498;33633747;33658483;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34185709;34211107;34229054;34357683;34433824;34509645;34647228;34725712;35051231;35251023;35254053;35318648;35513511;35580925;35593475;35705054;35772404;36215666;36241641;36284347;36882522;37217939;37368134;37895289;37938771;38665916;39215053;39225047;39531497;40307207;40596516;40914422;429297;592398;592399;641056;6853548;7000367;7935836;8139536;8449919;8816444;8943342;9045610;9099687;9721431;9732867;9857202",
        "class_list": "",
        "function": "Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B., [RefSeq, PubMed]; CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4beta., [RefSeq, PubMed]; DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs., [RefSeq, PubMed]; Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 21,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 21,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 21,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 54,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 25,
        "glyco_site_count": 21,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DS13;Q4G0E3;Q53HQ2;Q6GPH5;Q6IB46;Q8WYK5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016281 eukaryotic translation initiation factor 4F complex",
        "go_biological_process": "GO:0006446 regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 22.4,
        "record_id": "P23588-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UII4-1",
        "uniprot_id": [
            {
                "id": "HERC5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UII4",
                "type": "external"
            }
        ],
        "mass": 116852.0,
        "length": 1024,
        "protein_name": "E3 ISG15--protein ligase HERC5",
        "gene_name": "HERC5",
        "organism": "Human",
        "refseq_name": "E3 ISG15--protein ligase HERC5",
        "refseq_ac": [
            {
                "id": "NP_057407",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057407",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HERC5; CEB1; CEBP1",
        "gene_names_refseq": "CEB1; CEBP1; HERC5",
        "protein_names_uniprotkb": "E3 ISG15--protein ligase HERC5; 2.3.2.-; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5",
        "protein_names_refseq": "E3 ISG15--protein ligase HERC5; HECT domain and RCC1-like domain-containing protein 5; cyclin-E-binding protein 1; hect domain and RLD 5; probable E3 ubiquitin-protein ligase HERC5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51191);  (R-HSA-1169408);  (R-HSA-168928);  (R-HSA-936440);  (R-HSA-983168);  (R-HSA-9833110);  (R-HSA-9833482);  (R-HSA-9909505)",
        "pathway_count": 8,
        "publication_count": 312,
        "publication_id_list": "10082513;10348343;10400669;10581175;10620360;10626894;10648614;10848580;10866685;11062501;11095724;11096080;11112487;11134010;11152499;11156368;11157743;11237011;11238103;11238927;11278865;11313968;11337501;11350924;11350938;11438540;11500375;11607032;11781817;11788588;11909525;11939789;11985496;12231563;12397061;12525615;12582176;12646216;12882984;1373135;14585331;14734113;14976261;15131269;15208624;15224091;15224092;15229216;15299030;15331633;15485925;15571818;15702989;15737233;15752359;15907845;16009940;16112642;16122702;16125763;16127453;16139798;16153868;16179258;16179259;16352599;16373505;16394098;16407192;16428300;16431927;16595681;16600570;16699525;16715065;16717090;16775314;16815975;16849449;16872604;16884686;16914094;16954532;1695551;16982605;17079286;17196820;17289916;17376915;17392790;17600090;17991829;18057259;18096616;18200010;18287095;18305167;18307765;18420935;18452278;18583345;18591409;18662542;18835251;18957415;19017631;19028597;19073728;19125153;19229320;19270716;19352404;19416861;19452197;19484123;19489725;19531363;19710021;19733181;19804757;19838063;19851334;19874575;19881509;19893624;19940261;20133869;20219937;20304918;20308324;20385878;20395957;20403326;20410276;20434986;20519500;20542004;20628368;20685959;21072047;21123651;21294215;21518807;21636578;21937648;21978664;21994559;22090124;22093708;22214662;22424782;2247437;2261476;22986343;23084476;23229543;23481700;23732991;24347309;24366607;24623135;24659800;24714562;24753571;24755855;25418920;25576301;25645385;25653431;25802875;25848059;25854864;25880248;26101251;26154972;26355087;26375851;26432638;26446704;26488609;26716879;26728094;26817845;26929215;26992070;27208315;27269119;27423063;27534820;27543614;27564865;27846572;27862975;27893789;27920218;27974558;28069888;28167698;28218747;28228285;28281686;28446606;28514659;28765891;28832583;28834231;28855257;28904123;29170442;29175459;29231267;29242379;29348664;29393594;29394925;29395325;29437277;29440070;29493099;29501855;29508533;29557506;29632046;29786170;30169894;30174290;30224801;30315122;30379171;30410026;30770398;30779550;30833945;31031002;31092671;31154438;31217245;31434731;31455651;31492838;31530632;31844290;31848261;31998317;32093270;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32716602;32801355;32897882;32938616;32983136;33298915;33592498;33717175;33808629;33911136;33912179;33968037;34171305;34174402;34509645;34572049;34661519;34932366;34974812;35051231;35580925;35671810;35685460;35947956;36010968;36102648;36241641;36284347;36712380;36793726;37127961;37279284;37651190;37938771;38605423;7491766;7515177;7545299;7559393;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9380723;9442054;9521856;9525617;9528799;9668046;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "(Microbial infection) Functions as an E3 ligase for ISGylation of hepatitis B virus protein X leading to enhanced viral replication due to increased interferon resistance., [UniProtKB, PubMed]; Data show that HERC5, a functionally active HECT ubiquitin ligase, exhibits a tightly controlled cytosolic level under inflammatory conditions in endothelial cells., [RefSeq, PubMed]; HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication., [RefSeq, PubMed]; HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; HERC5/Ceb1 is involved in the conjugation of ISG15 to cellular proteins., [RefSeq, PubMed]; HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration., [RefSeq, PubMed]; Major E3 ligase for ISG15 conjugation (PubMed:26355087, PubMed:27534820, PubMed:27564865, PubMed:34572049, PubMed:37279284). Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance (PubMed:37279284). Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG (PubMed:22093708, PubMed:34572049). Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Promotes parkin/PRKN ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation (PubMed:27534820)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN., [RefSeq, PubMed]; This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTQ1;Q69G20",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "6.3.2.n3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0042296 ISG15 transferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0016567 protein ubiquitination;GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 31.5,
        "record_id": "Q9UII4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15751-1",
        "uniprot_id": [
            {
                "id": "HERC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15751",
                "type": "external"
            }
        ],
        "mass": 532228.0,
        "length": 4861,
        "protein_name": "Probable E3 ubiquitin-protein ligase HERC1",
        "gene_name": "HERC1",
        "organism": "Human",
        "refseq_name": "probable E3 ubiquitin-protein ligase HERC1",
        "refseq_ac": [
            {
                "id": "NP_003913",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003913",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HERC1",
        "gene_names_refseq": "HERC1; MDFPMR; p532; p619",
        "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase HERC1; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; p532; p619",
        "protein_names_refseq": "HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; guanine nucleotide exchange factor p532; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1; probable E3 ubiquitin-protein ligase HERC1",
        "tax_id": 9606,
        "disease": "macrocephaly, dysmorphic facies, and psychomotor retardation (MONDO:MONDO:0014863)",
        "pathway": " (hsa:8925);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 141,
        "publication_id_list": "10.1101/2023.09.13.557529;11062501;11237011;11350924;12646216;12650930;14734113;14960311;15224091;15224092;15571818;15642342;16464865;16595681;16849449;16954532;17081983;17287340;17525332;18077418;18220336;18662542;18669648;19028597;19352404;19413330;19452197;19489725;19651622;19690332;19851334;19874575;19940261;20068231;21406692;22424782;22544926;2261476;22645359;22706990;23186163;23481700;24275569;24366607;24397554;24714562;24715725;25418920;25505266;25576301;25645385;25880248;25892735;26024233;26138117;26154972;26375851;26728094;26811146;26929215;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28446606;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29463886;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30192525;30315122;30410026;30418433;30429286;30524438;31217245;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34211107;34357683;34405274;34446601;34509645;34561969;34932366;34990797;35051231;35154160;35251023;35254053;35318648;35580925;36010968;36215666;36241641;36284347;37340703;37932766;37938771;38253038;39093953;8861955;9233772;9380723;9668046",
        "class_list": "",
        "function": "CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; HERC1 overexpression does not stimulate protrusion formation in the absence of AlF(4)(-), in conditions where ARNO does, indicating that HERC1 is not acting as an ARF6-GEF, but instead its recruitment takes place downstream of ARF6 activation, [RefSeq, PubMed]; Identification of a quality-control factor that monitors failures during proteasome assembly., [RefSeq, PubMed]; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, PubMed, PubMed, PubMed]; Physical interaction between the HECT domain of HERC1, a giant protein involved in intracellular membrane traffic, and the M2 isoform of glycolytic enzyme pyruvate kinase (M2-PK), [RefSeq, PubMed]; The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia., [RefSeq, PubMed]; The Herc1 gene in neurobiology. Review article, [RefSeq, PubMed]; This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 85,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IW65",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 15.0,
        "record_id": "Q15751-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.000100.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22732-1",
        "uniprot_id": [
            {
                "id": "GTR5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22732",
                "type": "external"
            }
        ],
        "mass": 54974.0,
        "length": 501,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 5",
        "gene_name": "SLC2A5",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001129057",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129057",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC2A5; GLUT5",
        "gene_names_refseq": "GLUT-5; GLUT5; SLC2A5",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; GLUT-5; Glucose transporter type 5, small intestine",
        "protein_names_refseq": "glucose transporter type 5, small intestine; glucose transporter-like protein 5; solute carrier family 2 (facilitated glucose/fructose transporter), member 5; solute carrier family 2, facilitated glucose transporter member 5 isoform 2; testicular tissue protein Li 81",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6518);  (R-HSA-6798695);  (R-HSA-8981373)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "11237011;11840567;12885248;1550217;15546855;16186102;1634504;16788146;1695905;1701966;17710649;18452278;23328677;23650620;24397554;25576301;25892735;26992070;28083649;28228285;28467828;28832583;29242379;29314611;29548810;29557506;29769354;30315122;30410026;30429286;31217245;31844290;31848261;31998317;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32967941;33912179;34357683;35051231;35154160;35387598;35580925;36746764;37507736;37674366;7619085;8037665;8333543;8457197;8563765;8692836;9354798;9751501",
        "class_list": "glycogene",
        "function": "Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GLUT5: structure, functions, diseases and potential applications. Review article, [RefSeq, PubMed]; Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption. Publication Status: Online-Only, [RefSeq, PubMed]; Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum., [RefSeq, PubMed]; The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 612,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14770;Q5T977;Q8IVB3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0070061 fructose binding;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:0106001 intestinal hexose absorption;GO:1904659 D-glucose transmembrane transport;GO:0005975 carbohydrate metabolic process;GO:0009750 response to fructose",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "P22732-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011001.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13303-1",
        "uniprot_id": [
            {
                "id": "KCAB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13303",
                "type": "external"
            }
        ],
        "mass": 41000.0,
        "length": 367,
        "protein_name": "Voltage-gated potassium channel subunit beta-2",
        "gene_name": "KCNAB2",
        "organism": "Human",
        "refseq_name": "voltage-gated potassium channel subunit beta-2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001186789",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186789",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNAB2; KCNA2B; KCNK2",
        "gene_names_refseq": "AKR6A5; HKvbeta2.1; HKvbeta2.2; HKvbeta2; KCNA2B; KCNAB2; KV-BETA-2",
        "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-2; 1.1.1.-; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2",
        "protein_names_refseq": "K(+) channel subunit beta-2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; voltage-gated potassium channel subunit beta-2 isoform 1",
        "tax_id": 9606,
        "disease": "chromosome 1p36 deletion syndrome (Disease Ontology:DOID:0060410)",
        "pathway": " (hsa:8514);  (R-HSA-1296072);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 57,
        "publication_id_list": "11086297;11237011;11825900;14978097;15592455;19608861;19690332;19901323;20393197;21231794;21357749;23186163;23650620;24129315;24715725;25418920;26154972;26375851;26992070;27600516;27846572;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29557506;30315122;30524438;31492838;31844290;32109873;32157095;32350084;32357974;32387766;32488085;32938616;32983136;33043033;33691108;33717175;33912179;34357683;34509645;34561969;34932366;35051231;35154160;35580925;36010968;36359834;40596516;7649300;8692836",
        "class_list": "",
        "function": "Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Role of KCNAB2 expression in modulating hormone secretion in somatotroph pituitary adenoma. Publication Status: Online-Only, [RefSeq, PubMed]; The Ion Channel Gene KCNAB2 Is Associated with Poor Prognosis and Loss of Immune Infiltration in Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVM9;A8K1A4;B0AZR7;O43659;Q2YD85;Q5TG82;Q5TG83;Q6ZNE4;Q99411",
        "ec_number_list": [
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "1.14.19.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17",
                "type": "external"
            },
            {
                "id": "5.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-",
                "type": "external"
            },
            {
                "id": "1.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20",
                "type": "external"
            },
            {
                "id": "1.1.1.300",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300",
                "type": "external"
            },
            {
                "id": "1.1.1.54",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54",
                "type": "external"
            },
            {
                "id": "2.3.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20",
                "type": "external"
            },
            {
                "id": "2.3.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.4.21.73",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "1.6.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-",
                "type": "external"
            },
            {
                "id": "1.1.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2",
                "type": "external"
            },
            {
                "id": "1.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-",
                "type": "external"
            },
            {
                "id": "1.1.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19",
                "type": "external"
            },
            {
                "id": "1.1.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20",
                "type": "external"
            },
            {
                "id": "1.1.1.372",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "1.14.14.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18",
                "type": "external"
            },
            {
                "id": "1.2.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5",
                "type": "external"
            },
            {
                "id": "1.2.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28",
                "type": "external"
            },
            {
                "id": "1.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7",
                "type": "external"
            },
            {
                "id": "1.2.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "3.2.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6",
                "type": "external"
            },
            {
                "id": "3.1.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.1.78",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity;GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:2000008 regulation of protein localization to cell surface",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q13303-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q04724-1",
        "uniprot_id": [
            {
                "id": "TLE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q04724",
                "type": "external"
            }
        ],
        "mass": 83201.0,
        "length": 770,
        "protein_name": "Transducin-like enhancer protein 1",
        "gene_name": "TLE1",
        "organism": "Human",
        "refseq_name": "transducin-like enhancer protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001290032",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290032",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TLE1",
        "gene_names_refseq": "ESG1; ESG; GRG1; TLE-1; TLE1",
        "protein_names_uniprotkb": "Transducin-like enhancer protein 1; E(Sp1) homolog; ESG1; Enhancer of split groucho-like protein 1",
        "protein_names_refseq": "enhancer of split groucho-like protein 1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer protein 1 isoform 1; transducin-like enhancer protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7088);  (R-HSA-201722);  (R-HSA-2122947);  (R-HSA-3769402);  (R-HSA-4641265);  (R-HSA-9764725)",
        "pathway_count": 6,
        "publication_count": 196,
        "publication_id_list": "10080941;10375506;10485845;10549281;10559189;10655587;10660609;10713164;10748198;10769018;10775268;10831834;10898789;10919662;10921920;10944533;10964718;11044625;11050151;11080158;11136974;11237011;11266540;11290324;11461910;11532957;11585921;11691915;11713476;11731482;11912130;11934263;11955446;11973335;11988739;12050117;12057191;12163411;12391150;12397081;12408824;12408825;12441302;12700765;12711682;12712206;1303260;14600025;14651967;14685266;14695187;14980219;15060161;15107403;15121853;15132997;15187083;15294866;15327769;15367661;15525529;15542832;15546612;15768032;15829968;16005293;16169192;16256737;16510874;16530044;16547505;16630820;16756492;17052462;17114293;17130829;17218525;17412698;17425782;17428831;17458864;17698607;17875931;18094723;18160704;18254933;18347063;18374649;18378692;18404694;18456656;18498752;18573912;18598779;18621708;18721877;18819930;19047045;19148484;19364920;19413330;19460168;19487454;19493659;19571879;19590513;19664994;19664995;19928349;19940019;20405012;20418909;20871592;20972443;21406692;21429299;21654818;21726809;22158034;22186018;22190459;22304967;22354967;22617422;22982193;23256519;23466526;24291232;25728771;26154972;26212009;27846572;27920218;28832583;28904123;29242379;29393594;29437277;29557506;29729076;29758293;30315122;30429286;30484775;30620550;30833945;30898548;31154438;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32938616;33608512;33912179;33968037;33981976;34048198;35008676;35051231;35138000;35292107;35851744;36215666;36284347;36945158;37541260;37819496;40307207;7566092;7588063;8001118;8365415;8649374;8687460;8756721;8757136;8955148;9118222;9334241;9488439;9490669;9694793;9751710;9783587;9819412;9843967;9854018;9874198;9887105",
        "class_list": "",
        "function": "Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters., [RefSeq, PubMed]; GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR., [RefSeq, PubMed]; Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K495;Q5T3G4;Q969V9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:1990907 beta-catenin-TCF complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 20.3,
        "record_id": "Q04724-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBW7-1",
        "uniprot_id": [
            {
                "id": "ZMYM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBW7",
                "type": "external"
            }
        ],
        "mass": 154911.0,
        "length": 1377,
        "protein_name": "Zinc finger MYM-type protein 2",
        "gene_name": "ZMYM2",
        "organism": "Human",
        "refseq_name": "zinc finger MYM-type protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001177893",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177893",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZMYM2; FIM; RAMP; ZNF198",
        "gene_names_refseq": "FIM; MYM; NECRC; RAMP; SCLL; ZMYM2; ZNF198",
        "protein_names_uniprotkb": "Zinc finger MYM-type protein 2; Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198",
        "protein_names_refseq": "fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder; zinc finger MYM-type protein 2 isoform 1; zinc finger protein 198; zinc finger, MYM-type 2",
        "tax_id": 9606,
        "disease": "neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities (MONDO:MONDO:0859190)",
        "pathway": " (hsa:7750);  (R-HSA-1839117);  (R-HSA-5655302);  (R-HSA-9703465);  (R-HSA-9764725)",
        "pathway_count": 5,
        "publication_count": 205,
        "publication_id_list": "10.1101/2023.09.13.557529;10469654;10480903;10579907;10652257;10655587;10688839;10887137;10918587;10935490;11027663;11157491;11230166;11237011;11429702;11689702;11739186;11912130;12124177;12393597;12468433;12493763;12700765;14534538;14660670;15003515;15034873;15050920;15302935;15448205;15498859;15542832;15609342;15800673;16091734;16761019;16844695;16946300;16964243;17130829;17268528;17505008;17533378;17698633;17764812;18192505;18205209;18337450;18373495;18381441;18412956;18452278;18491316;18552176;18669648;18757403;18767875;19103595;19147536;19345670;19369959;19381019;19413330;19438505;19664994;19664995;19690332;19749790;19809159;19874848;19946327;20068231;20094046;20179196;20226962;20418909;20709759;20871592;21072051;21160078;21262971;21330321;21406692;21666749;21705501;21711248;22158034;22424782;22438257;23103841;23168613;23186163;23466526;23481700;24366607;24715725;24854988;25218447;25505266;25576301;25645385;25728771;25755297;25772364;25880248;25892735;26154972;26212009;26308771;26375851;26716518;26992070;27600516;27666490;27795560;27846572;27920218;28028030;28063628;28218747;28228285;28514659;28751768;28832583;28834231;28904123;29025582;29242379;29393594;29437277;29493099;29507660;29508533;29557506;29632046;29632711;29729076;29786170;29880609;30315122;30370255;30379171;30410026;30429286;30559310;30898548;31066629;31359998;31844290;32157095;32357974;32387766;32488085;32502341;32522876;32891193;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33537174;33592498;33608512;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34932366;34935912;35008676;35051231;35138000;35292107;35313791;35561310;35580925;35851744;36010968;36241641;36284347;37395395;37934570;37938771;39302247;9425908;9499416;9576949;9694738;9716603;9857065;9889006;9918857;9949182",
        "class_list": "",
        "function": "Involved in the negative regulation of transcription., [UniProtKB, PubMed]; Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations., [RefSeq, PubMed]; Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells., [RefSeq, PubMed]; The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]., [RefSeq]; UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization., [RefSeq, PubMed]; ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes. Publication Status: Online-Only, [RefSeq, PubMed]; ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDG0;A6NI02;O43212;O43434;O60898;Q5W0Q4;Q5W0T3;Q63HP0;Q8NE39;Q9H0V5;Q9H538;Q9UEU2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031624 ubiquitin conjugating enzyme binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016605 PML body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 21.0,
        "record_id": "Q9UBW7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQC8-1",
        "uniprot_id": [
            {
                "id": "IFT46_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQC8",
                "type": "external"
            }
        ],
        "mass": 34286.0,
        "length": 304,
        "protein_name": "Intraflagellar transport protein 46 homolog",
        "gene_name": "IFT46",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 46 homolog isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001162089",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162089",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFT46; C11orf2; C11orf60",
        "gene_names_refseq": "C11orf2; C11orf60; CFAP32; FAP32; IFT46",
        "protein_names_uniprotkb": "Intraflagellar transport protein 46 homolog",
        "protein_names_refseq": "UPF0360; cilia and flagella associated protein 32; intraflagellar transport 46 homolog; intraflagellar transport protein 46 homolog isoform 2; intraflagellar transport protein 46 homolog; intraflagellar transport protein IFT46",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56912);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 100,
        "publication_id_list": "10069812;10873569;11230166;11237011;11285270;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;17720815;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22645359;22898188;22922713;22992454;23481700;23945166;23990561;24140113;24296415;24339792;24596149;24616010;24715725;25205765;25349261;25418920;25443296;25860617;26375851;26992070;27846572;27920218;28218747;28228285;28832583;29331515;29393594;29437277;29493099;30524438;30779550;31154438;31217245;31222486;31530632;31844290;31848261;32357974;32488085;32897882;32938616;33298915;33633747;33691108;33717175;33968037;34087483;34171305;35051231;36010968;36215666;36241641;37217939;39894887;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)., [UniProtKB]; The ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0F6;Q9H6V5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005815 microtubule organizing center",
        "go_biological_process": "GO:0050821 protein stabilization;GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035720 intraciliary anterograde transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9NQC8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P42338-1",
        "uniprot_id": [
            {
                "id": "PK3CB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P42338",
                "type": "external"
            }
        ],
        "mass": 122762.0,
        "length": 1070,
        "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform",
        "gene_name": "PIK3CB",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1",
        "refseq_ac": [
            {
                "id": "NP_006210",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006210",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIK3CB; PIK3C1",
        "gene_names_refseq": "P110BETA; PI3KBETA; PI3K; PIK3C1; PIK3CB",
        "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; 2.7.1.153; 2.7.11.1; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB; p110beta",
        "protein_names_refseq": "PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; PtdIns-3-kinase p110; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; phosphoinositide-3-kinase, catalytic, beta polypeptide; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB",
        "tax_id": 9606,
        "disease": "thrombosis (Disease Ontology:DOID:0060903); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); rectal benign neoplasm (Disease Ontology:DOID:1984); prostate adenocarcinoma (Disease Ontology:DOID:2526); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:5291);  (R-HSA-109704);  (R-HSA-112399);  (R-HSA-114604);  (R-HSA-1257604);  (R-HSA-1660499);  (R-HSA-186763);  (R-HSA-198203);  (R-HSA-201556);  (R-HSA-202424);  (R-HSA-2029485);  (R-HSA-210993);  (R-HSA-2219530);  (R-HSA-2424491);  (R-HSA-2730905);  (R-HSA-373753);  (R-HSA-389357);  (R-HSA-4420097);  (R-HSA-512988);  (R-HSA-5673001);  (R-HSA-6811558);  (R-HSA-8853659);  (R-HSA-9027276);  (R-HSA-912526);  (R-HSA-912631);  (R-HSA-9673767);  (R-HSA-9673770);  (R-HSA-9680350);  (R-HSA-9725370);  (R-HSA-9842640);  (R-HSA-9842663);  (R-HSA-9856530);  (R-HSA-9927354)",
        "pathway_count": 33,
        "publication_count": 759,
        "publication_id_list": "10021361;10026222;10037737;10051567;10068651;10072481;10075701;10191262;10194437;10194451;10207047;10207622;10216106;10224048;10224278;10224668;10376603;10393930;10395673;10445845;10448070;10455108;10469124;10477686;10477722;10508167;10508235;10521483;10541305;10555148;10556217;10559940;10570274;10579907;10587647;10593988;10611248;10639123;10649434;10677529;10692392;10698680;10702393;10706082;10706887;10716940;10744696;10744763;10749680;10753883;10764742;10805725;10811803;10822173;10869344;10934142;10949031;10982827;10995764;11000521;11001876;11002419;11007481;11016459;11027663;11048639;11063744;11084340;11090077;11094073;11110708;11121404;11136978;11147812;11191051;11237011;11237712;11262396;11278486;11278720;11279162;11280786;11302699;11310834;11313946;11328862;11340081;11340297;11349134;11358993;11360177;11368773;11390647;11390650;11425868;11447223;11470823;11481033;11491658;11504915;11546808;11562357;11566266;11598010;11604140;11607834;11607835;11676921;11689432;11695992;11696015;11702783;11733541;11733557;11749377;11751994;11803464;11850821;11853546;11877430;11884229;11886862;11907067;11923287;11943732;11968001;11969368;11988758;12032311;12094235;12101241;12112524;12118066;12121613;12122009;12134158;12138205;12167717;12176338;12185581;12214271;12215529;12242309;12324459;12391143;12422219;12424201;12464388;12471105;12473184;12502714;12506011;12522257;12536145;12538664;12569364;12646134;12660326;12660731;12668668;12670391;12724311;12750159;12767043;12771945;12800156;12808147;12810700;12813055;12820653;12832405;12846735;12847086;12865409;12869549;12881521;12882960;12911816;12920229;12934099;12949711;1314164;1325671;1334462;1374684;1375321;1381348;1396555;1396585;1400495;14506247;14514672;14516276;14563642;14570703;14617813;14633607;1465135;14660569;14665640;14695357;14707138;14724572;14749497;14766744;14962911;15007255;15010370;15026417;15044950;15080793;15107860;15122200;15125833;15135396;15145317;15149544;15161916;15169778;15184383;15208656;15221957;15226403;15247219;15286081;15294978;15304325;15308621;15308668;15317731;15331416;15356145;15365099;15371334;15374880;1545823;15464023;15536084;15541657;15545998;15546878;15569713;15579503;15588951;15592455;15634346;15644415;15688067;15695828;15708849;15716355;15718470;15797027;15809313;15834429;15840652;15843475;15870016;15893672;15895073;15928335;15938644;15962004;15994232;16056267;16153455;16154996;16161041;16170336;16174766;16317043;16336962;16339315;16356853;16356855;16399794;16456001;16456541;16476736;16497229;16522682;16525419;16543952;16612002;16627759;16630808;16647110;16678913;16684964;16760434;16780920;16825495;16847462;16871283;16878150;16895971;16914545;16938345;16939498;16966330;16978534;16979564;17008356;1702217;17030947;17038317;17047224;17072321;17086210;17135271;1716764;17185414;17199126;17200115;17202354;17237347;17245604;17274988;17293873;17353907;17363905;17416736;17468049;17483340;17496917;17548359;17590538;17616532;17625570;17626883;17651088;17681947;17686471;17728323;17893108;17923684;17993265;17998941;18033240;18070884;18079394;18093523;18097461;18317450;1833064;1833065;18374639;18439422;18452557;18467591;18589439;18593892;18594010;18594509;18606717;18691974;18692472;18701132;18710921;18724359;1874735;18753295;18754654;18755892;18775330;18829560;18849880;18923523;18923524;18923525;18925875;18955485;1898771;18990089;19020623;19038970;19185485;19230644;19267251;19279408;19409513;19411071;19438505;19443634;19456272;19459784;19576174;19592646;19635806;19644473;19665053;19700402;19723632;19805105;19815557;19850008;19896968;19920141;19962665;20231295;20233749;20338997;20454865;20478380;20484116;20489731;20522708;20534812;20548102;20632993;2065657;20658524;20713702;20719933;20889717;21030680;21035500;21049007;21102635;21134980;21154129;21164297;21188471;21204784;21213368;21317208;21321382;21345110;21368164;21372320;21383062;21415216;21445309;21478295;21494621;21596819;21653832;21656749;21659545;21668414;2174051;21779497;21779505;21827948;21838707;21847362;2196173;21976531;21984976;21993244;22037487;22089421;22120714;22153499;22162641;22188813;22249260;22267732;22286764;22327215;22327622;22347464;22347506;22439933;22483114;22569528;22570254;22588880;22589270;22647598;22658521;22689825;22750304;22802530;23103841;23104988;23139213;23201355;23216836;23239810;23303910;23443682;23519112;23575685;23661334;23669310;2374928;23752188;23758345;23889739;23957430;23970477;24060861;24356251;24366607;24445538;24475247;24496003;24518094;24613930;2466336;24670165;24714562;2472219;24736079;24736082;24890514;24897931;24937142;24947326;25219551;25331893;25342631;25393796;25421750;25495341;2555171;25576301;25645385;25781681;25813404;25880691;25921060;26001147;26029847;26062823;26085527;26154972;26235028;26301689;26418745;26464158;26630010;26708155;2681215;26992070;27170215;27245569;27566546;27573755;27600516;27780853;27797339;27874193;28218747;2833705;28351781;28404650;2841328;28659337;28736554;28741662;28778966;28832583;28834231;29242379;29380702;29393594;29408302;29437277;29455642;29557506;29632046;29873274;29964125;30061385;30131584;30315122;30389923;30692217;30784271;31135801;31154438;31205027;31217245;31222486;31366041;31585938;31844290;31848261;31998317;32157095;32161166;32296767;32350084;32357974;32387766;32488085;32502341;32606397;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33968037;33981976;34499618;34509645;34646012;34819663;34819673;34932366;35051231;35580925;36010968;36241641;37402056;38253038;38713746;38757931;39190024;6148751;7478529;7479848;7509446;7513165;7517665;7537740;7543144;7597091;7608176;7624799;7637810;7651724;7665556;7681396;7685273;7691811;7692233;7737969;7744773;7809086;7824924;7876172;7935391;7935463;7954816;7972015;8007942;8052307;8084588;8228618;8246984;8294403;8355686;8388543;8394845;8443409;8483502;8493579;8550590;8601309;8617235;8617742;8621607;8626543;8628282;8631863;8633037;8637703;8645157;8647804;8647855;8649859;8657103;8657148;8657151;8662982;8663278;8663426;8665852;8673706;8674117;8681945;8700127;8702662;8710374;8723348;8769125;8939933;8940081;8943348;8947042;8980223;8981370;8986718;8990121;8995358;9028946;9030599;9047384;9094719;9099679;9099726;9108392;9111318;9113989;9162089;9182576;9192684;9200440;9211928;9223670;9225065;9252186;9259313;9286278;9295334;9299438;9334184;9362451;9367159;9393975;9396765;9398617;9407096;9422786;9428629;9438848;9472046;9484840;9488729;9490415;9491986;9514948;9516481;9524259;9525940;9546424;9590251;9593664;9604935;9620797;9632797;9660759;9660833;9685210;9687533;9690470;9736715;9739761;9764818;9764820;9766809;9768361;9811831;9819383;9830044;9830063;9883723;9885561;9895304;9927426;9973503;9990853",
        "class_list": "",
        "function": "Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular dissection of PI3Kbeta synergistic activation by receptor tyrosine kinases, GbetaGgamma, and Rho-family GTPases. Publication Status: Online-Only, [RefSeq, PubMed]; PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells., [RefSeq, PubMed]; PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G protein-coupled receptor (GPCR) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Also has a protein kinase activity showing autophosphorylation (PubMed:12502714)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]., [RefSeq]; This paper reports the first purification of a phosphoinositide 3-kinase and shows that the protein is a heterodimer of an 85 kd regulatory subunit that mediates binding to phosphorylated proteins and a 110 kd catalytic subunit., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 57,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNF0;Q24JU2",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "3.2.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.1.151",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151",
                "type": "external"
            },
            {
                "id": "2.7.1.140",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.1.3.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0043560 insulin receptor substrate binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0002931 response to ischemia;GO:0006897 endocytosis;GO:0006935 chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 76.4,
        "record_id": "P42338-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NFM7-1",
        "uniprot_id": [
            {
                "id": "I17RD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NFM7",
                "type": "external"
            }
        ],
        "mass": 82411.0,
        "length": 739,
        "protein_name": "Interleukin-17 receptor D",
        "gene_name": "IL17RD",
        "organism": "Human",
        "refseq_name": "interleukin-17 receptor D isoform b",
        "refseq_ac": [
            {
                "id": "NP_001305793",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305793",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL17RD; IL17RLM; PRO20026; SEF",
        "gene_names_refseq": "HH18; IL-17RD; IL17RD; IL17RLM; SEF",
        "protein_names_uniprotkb": "Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; IL17Rhom; Interleukin-17 receptor-like protein; Sef homolog; hSef",
        "protein_names_refseq": "IL-17 receptor D; IL17Rhom; interleukin-17 receptor D isoform b; interleukin-17 receptor-like protein; sef homolog; similar expression to fgf genes",
        "tax_id": 9606,
        "disease": "hypogonadotropic hypogonadism 18 with or without anosmia (Disease Ontology:DOID:0090076)",
        "pathway": " (hsa:54756);  (R-HSA-5674135)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10.1101/2023.09.13.557529;10209122;10409742;10725339;10891492;11237011;11802164;11802165;12473660;12479806;12604616;12807873;12832465;12958313;12975309;14636584;14742870;14970219;15118098;15239952;15260967;15520807;15543157;15547943;16135787;16879721;17178906;17496912;17563371;19091303;19219045;19242111;19279408;20858867;21779496;22177953;22569528;23481700;23614898;23643382;23667175;23934108;24746704;24937142;25195011;25313996;25435214;25645385;27227380;27862975;28228285;28939558;29242379;29467321;29557506;29786170;30034615;30779550;30794926;31154438;31175175;31844290;31848261;32157095;32373127;32387766;32389901;3287375;32897882;32938616;33592498;33968037;34171305;34509645;35051231;36010968;7565670;7565795;7731720;7929275;7935411;8051079;8157000;9020159;9733512;9858547",
        "class_list": "",
        "function": "CUG codon functions as a major translation initiation site in the alternatively spliced transcript variant hSef-b., [RefSeq, PubMed]; Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12807873, PubMed:12958313). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952). Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Human SEF is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis, [RefSeq, PubMed]; IL-17RD is a functional receptor for IL-17A in vitro and in vivo and mediates the proinflammatory gene expression downstream of IL-17A.., [RefSeq, PubMed]; Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism., [RefSeq, PubMed]; Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling, [RefSeq, PubMed]; This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 9803,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2NKP7;Q58EZ7;Q6RVF4;Q6UWI5;Q8N113;Q8NFS0;Q9UFA0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030368 interleukin-17 receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0010719 negative regulation of epithelial to mesenchymal transition",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q8NFM7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P33992-1",
        "uniprot_id": [
            {
                "id": "MCM5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P33992",
                "type": "external"
            }
        ],
        "mass": 82286.0,
        "length": 734,
        "protein_name": "DNA replication licensing factor MCM5",
        "gene_name": "MCM5",
        "organism": "Human",
        "refseq_name": "DNA replication licensing factor MCM5",
        "refseq_ac": [
            {
                "id": "NP_006730",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006730",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCM5; CDC46",
        "gene_names_refseq": "CDC46; MCM5; MGORS8; P1-CDC46",
        "protein_names_uniprotkb": "DNA replication licensing factor MCM5; 3.6.4.12; CDC46 homolog; P1-CDC46",
        "protein_names_refseq": "CDC46 homolog; DNA replication licensing factor MCM5; MCM5 minichromosome maintenance deficient 5, cell division cycle 46; minichromosome maintenance deficient 5 (cell division cycle 46)",
        "tax_id": 9606,
        "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 8 (Disease Ontology:DOID:0080255); alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:4174);  (R-HSA-176187);  (R-HSA-176974);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-68962);  (R-HSA-69052);  (R-HSA-9825895)",
        "pathway_count": 8,
        "publication_count": 195,
        "publication_id_list": "10051570;10373362;10373557;10518787;10523313;10757793;10777662;10827953;10846177;10859164;10882098;10884341;11095689;11125146;11237011;11248027;11390642;11562349;11739726;11931757;12045100;12364596;12399544;12578958;12676583;12676925;12759351;12791985;12963847;14500360;14603323;14605214;14624239;14672932;15104674;15190204;15226314;15707391;15743907;15833913;16327781;16407120;16824194;16899510;17234884;17296731;17417653;17485488;18446792;18477386;18480045;18491316;19608861;19896182;20068231;20112406;21993680;22223895;22424782;23186163;23481700;23603117;23711367;23851460;24029068;24366607;24714562;24715725;25231993;25418920;25469497;25505266;25576301;25645385;25810538;25880248;26154972;26222030;26375851;26527279;26728094;26811146;26929215;26992070;27249176;27543614;27600516;27846572;27862975;27920218;28063628;28198391;28228285;28446606;28467828;28510447;28514659;28832583;28834231;28860189;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30069701;30315122;30395541;30410026;30429286;30484775;30524438;30779550;30784271;30833945;31154438;31217245;31222486;31530632;31630206;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32453425;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34694004;34700328;34725712;34932366;35051231;35138101;35154160;35318648;35490917;35561310;35580925;35585232;36010968;36215666;36241641;36284347;37029300;37171793;37385108;37938771;38665916;38686583;39894887;40914422;40940420;8196638;8265339;8943031;9278511;9278512;9635433;9660782",
        "class_list": "",
        "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB]; MCM5 is an oncogene of colon adenocarcinoma and promotes progression through cell cycle control., [RefSeq, PubMed]; MEG3 shuttled by exosomes released from human bone marrow mesenchymal stem cells promotes TP53 stability to regulate MCM5 transcription in keloid fibroblasts., [RefSeq, PubMed]; M[6] A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis., [RefSeq, PubMed]; Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway., [RefSeq, PubMed]; Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells., [RefSeq, PubMed]; The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60785;Q14578;Q9BTJ4;Q9BWL8",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "2.7.7.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-",
                "type": "external"
            },
            {
                "id": "2.7.7.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0000781 chromosome, telomeric region;GO:0042555 MCM complex",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 19.8,
        "record_id": "P33992-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N4C8-1",
        "uniprot_id": [
            {
                "id": "MINK1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N4C8",
                "type": "external"
            }
        ],
        "mass": 149822.0,
        "length": 1332,
        "protein_name": "Misshapen-like kinase 1",
        "gene_name": "MINK1",
        "organism": "Human",
        "refseq_name": "misshapen-like kinase 1 isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001020108",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020108",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MINK1; B55; MAP4K6; MINK; YSK2; ZC3",
        "gene_names_refseq": "B55; MAP4K6; MEKKK 6; MINK1; MINK; YSK2; ZC3",
        "protein_names_uniprotkb": "Misshapen-like kinase 1; 2.7.11.1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6",
        "protein_names_refseq": "GCK family kinase MINK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; misshapen-like kinase 1 isoform 4; misshapen/NIK-related kinase; mitogen-activated protein kinase kinase kinase kinase 6",
        "tax_id": 9606,
        "disease": "epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:50488);  (R-HSA-2559580)",
        "pathway_count": 2,
        "publication_count": 160,
        "publication_id_list": "10.1101/2023.09.13.557529;10347217;10708748;10722742;10772813;10871633;11237011;11564866;12134156;12189133;12193592;12421820;12435631;12507505;12668260;12808055;13130464;14507994;14532106;15287722;15302935;15469942;15563468;15866172;16186825;16337592;16436515;16760206;16826196;17016520;17081983;17210787;17254968;17255097;17332741;17344414;17344846;17389395;17395714;17765224;17825402;17875933;18088087;18220336;18365017;18452278;18491316;18669648;18691976;18793328;18930710;19369195;19451217;19451218;19462008;19528227;19651622;19690332;20068231;21406692;21690388;21986495;22020331;22325352;22336108;22683641;23186163;23481700;24129315;24275569;24714562;24715725;25418920;25576301;25645385;25810538;26154972;26375851;26437443;26728094;26992070;27397612;27862975;27920218;28218747;28657654;28832583;28834231;29242379;29371260;29393594;29557506;29632711;29786170;30315122;30429286;30484775;30833945;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33968037;34087483;34171305;34357683;34529319;34932366;35051231;35318648;35580925;35971817;36010968;36012658;36241641;36284347;38723371;39894887;7535770;7588633;7816143;7859739;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9162092;9195981;9529249;9564042;9628874;9768359;9824166",
        "class_list": "",
        "function": "Analysis of the coding region of the NIK gene in progressive supranuclear palsy (PSP) patients through single strand conformation polymorphism and direct sequencing does not support a pathogenic role of the NIK gene in PSP., [RefSeq, PubMed]; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration., [UniProtKB]; LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR-17-5p/MINK1-JNK pathway., [RefSeq, PubMed]; MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration., [RefSeq, PubMed]; Multi-Omic Investigations of a 17-19 Translocation Links MINK1 Disruption to Autism, Epilepsy and Osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results suggest that human Misshapen/NIKs-related kinase beta (hMINK beta) plays an important role in cytoskeleton reorganization, cell adhesion, and cell motility(hMINKbeta) Erratum:[J Biol Chem. 2005 Feb 11;280(6):5128], [RefSeq, PubMed]; Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins., [RefSeq, PubMed]; This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 31,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTK3;D3DTK4;Q5U8Z0;Q9P1X1;Q9P2R8",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030424 axon",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade;GO:0007254 JNK cascade;GO:0007268 chemical synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 16.5,
        "record_id": "Q8N4C8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P40305-2",
        "uniprot_id": [
            {
                "id": "IFI27_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P40305",
                "type": "external"
            }
        ],
        "mass": 11542.0,
        "length": 122,
        "protein_name": "Interferon alpha-inducible protein 27, mitochondrial",
        "gene_name": "IFI27",
        "organism": "Human",
        "refseq_name": "interferon alpha-inducible protein 27, mitochondrial isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001123552",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123552",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFI27",
        "gene_names_refseq": "FAM14D; IFI27; ISG12A; ISG12; P27",
        "protein_names_uniprotkb": "Interferon alpha-inducible protein 27, mitochondrial; ISG12(a); ISG12A; Interferon alpha-induced 11.5 kDa protein; Interferon-stimulated gene 12a protein; p27",
        "protein_names_refseq": "2310061N23Rik; ISG12(a); interferon alpha-induced 11.5 kDa protein; interferon alpha-inducible protein 27, mitochondrial isoform 1; interferon alpha-inducible protein 27, mitochondrial; interferon-stimulated gene 12a protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3429);  (R-HSA-909733);  (R-HSA-9909505)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10395669;10542297;10982844;11092454;11337497;11377645;11404376;11585831;11722583;12029096;12766484;12842042;12878323;14728724;14769151;15047845;15312780;15449939;15778442;16009940;16171819;16987978;17251292;1730654;17351669;17969444;18035202;18057259;18330707;18575461;20130243;20170512;20363976;20643137;2211721;22427340;23061660;23121362;23481700;23783831;24417533;24970806;25371710;25645385;26101251;26154972;26992070;27194766;27673746;27777077;27862975;28832583;28904123;29242379;29331515;29393594;29493099;29557506;29769354;29786170;29789417;30169894;30192525;30224801;30484775;30485383;30833945;31154438;31434731;31455651;31844290;31848261;32032529;32113509;32157095;32511913;32574262;32661006;32758689;32862111;32938616;32983136;33117408;33141586;33189161;33193462;33396578;33592498;33691108;33968037;34087483;34171305;34932366;35051231;35318648;35580925;36284347;36426955;36685600;36748518;36793726;36971141;37102643;37938771;6162102;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8358738;8605876;8621447;8702790;9096384;9121453;9242679;9334213;9660177;9847332;9861020",
        "class_list": "",
        "function": "Behcet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions., [RefSeq, PubMed]; IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Publication Status: Online-Only, [RefSeq, PubMed]; Integrative bulk and single-cell transcriptome profiling analysis reveals IFI27 as a novel interferon-stimulated gene in dengue., [RefSeq, PubMed]; Knockdown of NEAT1 restricts dengue virus replication by augmenting interferon alpha-inducible protein 27 via the RIG-I pathway., [RefSeq, PubMed]; Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:24970806, PubMed:27673746). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). Also promotes virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WZF8;A8K0H0;Q53YA6;Q6IEC1;Q7Z5R0;Q7Z5R1;Q7Z5R2;Q96BK3;Q9H4B1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0005521 lamin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.5,
        "record_id": "P40305-2",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z4H7-1",
        "uniprot_id": [
            {
                "id": "HAUS6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z4H7",
                "type": "external"
            }
        ],
        "mass": 108621.0,
        "length": 955,
        "protein_name": "HAUS augmin-like complex subunit 6",
        "gene_name": "HAUS6",
        "organism": "Human",
        "refseq_name": "HAUS augmin-like complex subunit 6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001257819",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257819",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAUS6; DGT6; FAM29A; KIAA1574",
        "gene_names_refseq": "Dgt6; FAM29A; HAUS6",
        "protein_names_uniprotkb": "HAUS augmin-like complex subunit 6",
        "protein_names_refseq": "HAUS augmin-like complex subunit 6 isoform 2; dim gamma-tubulin homolog; family with sequence similarity 29, member A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54801);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 8,
        "publication_count": 142,
        "publication_id_list": "10.1101/2023.09.13.557529;11076968;11237011;11956313;12207013;12221128;12364337;12852856;13678582;14580337;15498487;15705883;16357211;16462731;16565220;16890155;16964243;17322306;17574030;17646400;17719545;18037885;18220336;18378770;18443220;18477460;18521620;18566290;18615013;18669648;18691976;18694559;18767875;18801063;19004860;19007248;19029337;19081074;19369198;19413330;19427217;19651622;19664994;19664995;19690332;19691289;19940019;20068231;20230748;20308558;20399632;20558667;21273506;21347367;21406692;21422230;21548880;21565611;21620453;21725307;21792235;22094468;22179047;22365832;22433857;22641346;22653444;23141531;23141541;23186163;23253480;23301498;23348840;23400999;23481700;23530209;23747070;23769972;23789104;23921553;24053599;24089205;24231678;24469809;24715725;24982133;25047611;25313408;25532896;25576301;25892735;26154972;26992070;27600516;27846572;27920218;28063628;28228285;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;30315122;30723163;31113824;31217245;31222486;31530632;31844290;32157095;32161166;32350084;32357974;32387766;32897882;32938616;32983136;33298915;33402344;33717175;33912179;33936100;33968037;33981976;34171305;34509645;35561310;35580925;36010968;36241641;36581221;38759391;7769006;7790358;8838651",
        "class_list": "",
        "function": "Bioinformatics analysis and validation of HAUS6 as a key prognostic gene in squamous cell carcinoma of the tongue., [RefSeq, PubMed]; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin., [UniProtKB, PubMed, PubMed, PubMed]; FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle., [RefSeq, PubMed]; Our work shows that noncentrosomal microtubules nucleation is the predominant source of spindle microtubules also in human somatic cells. Importantly, our analysis of HAUS6-depleted cells shows that the Augmin complex is responsible for this activity., [RefSeq, PubMed]; Results suggest that an important mitotic function for gamma-tubulin may lie within the spindle, where augmin (Dgt2-6; FAM29A) and gamma-tubulin function cooperatively to amplify the number of microtubules., [RefSeq, PubMed]; The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 23,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPK4;B4DX82;Q05CG1;Q14CB6;Q14CD9;Q2TA91;Q6IQ10;Q6NZX5;Q8IZQ4;Q96FN0;Q9H950;Q9H998;Q9HCJ8;Q9NXT8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule",
        "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0007098 centrosome cycle;GO:0051225 spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "Q7Z4H7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NMD0-1",
        "uniprot_id": [
            {
                "id": "IFM10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NMD0",
                "type": "external"
            }
        ],
        "mass": 24599.0,
        "length": 228,
        "protein_name": "Interferon-induced transmembrane protein 10",
        "gene_name": "IFITM10",
        "organism": "Human",
        "refseq_name": "interferon-induced transmembrane protein 10",
        "refseq_ac": [
            {
                "id": "NP_001164291",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164291",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFITM10",
        "gene_names_refseq": "DSPA3; IFITM10",
        "protein_names_uniprotkb": "Interferon-induced transmembrane protein 10; DSPA3; Dispanin subfamily A member 3",
        "protein_names_refseq": "dispanin subfamily A member 3; interferon-induced transmembrane protein 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:402778)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;22363774;25645385;28514659;29786170;31154438;31324691;36284347",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NEU7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A6NMD0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TDG4-1",
        "uniprot_id": [
            {
                "id": "HELQ_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TDG4",
                "type": "external"
            }
        ],
        "mass": 124131.0,
        "length": 1101,
        "protein_name": "Helicase POLQ-like",
        "gene_name": "HELQ",
        "organism": "Human",
        "refseq_name": "helicase POLQ-like isoform 5",
        "refseq_ac": [
            {
                "id": "NP_001284687",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284687",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HELQ; HEL308",
        "gene_names_refseq": "HEL308; HELQ",
        "protein_names_uniprotkb": "Helicase POLQ-like; 5.6.2.4; Mus308-like helicase; POLQ-like helicase",
        "protein_names_refseq": "DNA helicase HEL308; POLQ-like helicase; helicase POLQ-like isoform 5; mus308-like helicase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:113510)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "11237011;11751861;12794064;16959974;18270339;19995904;20800603;21398521;24005041;24005565;25880248;28738244;28904123;29485866;29557506;29671580;30379171;31217245;31844290;32387766;32938616;33298915;33392160;33912179;33936100;33968037;33981976;34316696;34937945;35051231;36010968;36477533;36718939;37217939;37777152;37897354;38540391;38720471",
        "class_list": "",
        "function": "A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308, [RefSeq, PubMed]; HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]., [RefSeq]; HELQ deficiency impairs the induction of primordial germ cell-like cells. Erratum:[FEBS Open Bio. 2025 May;15(5):885. doi: 10.1002/2211-5463.70029. PMID: 40176377], [RefSeq, PubMed]; Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks., [RefSeq, PubMed]; Identification of homolog to POLN, [RefSeq, PubMed]; Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing., [RefSeq, PubMed]; Mitotic DNA Synthesis in Untransformed Human Cells Preserves Common Fragile Site Stability via a FANCD2-Driven Mechanism That Requires HELQ., [RefSeq, PubMed]; Observational study and meta-analysis of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:11751861, PubMed:19995904, PubMed:21398521, PubMed:24005041, PubMed:24005565, PubMed:34316696, PubMed:34937945). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed:34937945). Possesses both DNA unwinding and annealing activities (PubMed:34937945). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (PubMed:34937945). Efficiently unwinds substrates containing 3' overhangs or a D-loop (PubMed:21398521, PubMed:34937945). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (PubMed:34937945). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (PubMed:34316696, PubMed:34937945)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q05DF9;Q502W9;Q659B8;Q6ZQX4;Q6ZTS4;Q96EX7",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:1990518 single-stranded 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017116 single-stranded DNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0090734 site of DNA damage",
        "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing;GO:1905168 positive regulation of double-strand break repair via homologous recombination;GO:0045003 double-strand break repair via synthesis-dependent strand annealing",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8TDG4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96MB7-1",
        "uniprot_id": [
            {
                "id": "HARB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96MB7",
                "type": "external"
            }
        ],
        "mass": 39146.0,
        "length": 349,
        "protein_name": "Putative nuclease HARBI1",
        "gene_name": "HARBI1",
        "organism": "Human",
        "refseq_name": "putative nuclease HARBI1",
        "refseq_ac": [
            {
                "id": "NP_776172",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776172",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HARBI1; C11orf77",
        "gene_names_refseq": "C11orf77; HARBI1",
        "protein_names_uniprotkb": "Putative nuclease HARBI1; 3.1.-.-; Harbinger transposase-derived nuclease",
        "protein_names_refseq": "harbinger transposase-derived nuclease; putative nuclease HARBI1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283254)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;15169610;18339812;24715725;26992070;28218747;28228285;28832583;28834231;28904123;29242379;29437277;30315122;30410026;30429286;31844290;31848261;32157095;32488085;32938616;34561969;35580925;36284347;38253038",
        "class_list": "",
        "function": "The functions of two transposon-derived human proteins: HARBI1, a domesticated transposase-derived protein, and NAIF1, which contains a trihelix motif similar to that described in the Myb-like protein, was investigated., [RefSeq, PubMed]; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQP9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004518 nuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q96MB7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A2RTY3-1",
        "uniprot_id": [
            {
                "id": "HEAT9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A2RTY3",
                "type": "external"
            }
        ],
        "mass": 65681.0,
        "length": 570,
        "protein_name": "Protein HEATR9",
        "gene_name": "HEATR9",
        "organism": "Human",
        "refseq_name": "protein HEATR9 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001308324",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308324",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR9; C17orf66",
        "gene_names_refseq": "C17orf66; HEATR9",
        "protein_names_uniprotkb": "Protein HEATR9; HEAT repeat-containing protein 9",
        "protein_names_refseq": "HEAT repeat-containing protein 9; protein HEATR9 isoform 2; protein HEATR9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256957)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;16959974;20237496;29242379;30524438;31844290;35051231;35289036",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DX21;B4DXA4;B4DXF0;Q8N4R4;Q96M46",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "A2RTY3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MVW5-1",
        "uniprot_id": [
            {
                "id": "HECA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MVW5",
                "type": "external"
            }
        ],
        "mass": 51407.0,
        "length": 462,
        "protein_name": "HEPACAM family member 2",
        "gene_name": "HEPACAM2",
        "organism": "Human",
        "refseq_name": "HEPACAM family member 2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001034461",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034461",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEPACAM2; MIKI; PRO346",
        "gene_names_refseq": "HEPACAM2; MIKI",
        "protein_names_uniprotkb": "HEPACAM family member 2; Mitotic kinetics regulator",
        "protein_names_refseq": "HEPACAM family member 2 isoform 1 precursor; mitotic kinetics regulator",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:253012)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12975309;16959974;19358830;21248752;22864114;28228285;29557506;29789417;31844290;34087483;34185709;35051231;35580925;37074911",
        "class_list": "",
        "function": "Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The data suggest that PARsylation of Miki by tankyrase-1 is a key initial event promoting prometaphase., [RefSeq, PubMed]; This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTT4;B4DPJ1;B9EG93;E9PDV5;Q6UXI0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005819 spindle;GO:0030496 midbody",
        "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "A8MVW5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B0YJ81-1",
        "uniprot_id": [
            {
                "id": "HACD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B0YJ81",
                "type": "external"
            }
        ],
        "mass": 32388.0,
        "length": 288,
        "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1",
        "gene_name": "HACD1",
        "organism": "Human",
        "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1",
        "refseq_ac": [
            {
                "id": "NP_055056",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055056",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HACD1; PTPLA",
        "gene_names_refseq": "CAP; CMYO11; CMYP11; HACD1; MYONP; PTPLA",
        "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; 3-hydroxyacyl-CoA dehydratase 1; 4.2.1.134; CAP; Cementum-attachment protein; HACD1; Protein-tyrosine phosphatase-like member A",
        "protein_names_refseq": "cementum attachment protein; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1",
        "tax_id": 9606,
        "disease": "congenital myopathy (Disease Ontology:DOID:0081337); cancer (Disease Ontology:DOID:162); congenital myopathy 11 (MONDO:MONDO:0859264)",
        "pathway": " (hsa:9200);  (R-HSA-75876)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10548543;10644438;10954726;11054553;11237011;11889465;12371743;12482854;12525535;12975357;15469937;15829503;16036915;16371355;16385451;17379924;17681178;17762044;18003621;18554506;18669648;18728184;19505953;19826053;20068231;20937905;21959040;22067203;23933735;25263524;25576301;26992070;27600516;27939133;28784662;28834231;29242379;29331515;29393594;29632046;29769354;30524438;30779550;31844290;32157095;32357974;32387766;32426512;32938616;33354762;33392160;34509645;35318648;35580925;36010968;37938771;38422897;8075637",
        "class_list": "",
        "function": "A loss-of-function mutation in the canine ortholog of HACD1 that was identified by genetic mapping in a French pedigree of Labrador retrievers causes a congenital myopathy named centronuclear myopathy (CNM) in Labrador retrievers. Erratum:[Hum Mol Genet. 2005 Jul 1;14(13):1905-6], [RefSeq, PubMed]; Biallelic loss-of-function HACD1 variants are a bona fide cause of congenital myopathy., [RefSeq, PubMed]; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB, UniProtKB, PubMed]; In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum., [UniProtKB, PubMed]; Longitudinal analyses in myopathic Labrador retrievers reveal several membrane-associated defects, including ultrastructural triads dysmorphogenesis and mitochondrial mislocalization in Labrador retrievers with deficiencies in the canine HACD1 gene., [RefSeq, PubMed]; Mutations in HACD1 can result in myopathies in humans; knockout mice lacking Hacd1 develop myopathic phenotypes. Data (including data from studies using knockout mice and cultured cells from knockout mice) suggest that HACD1 and HACD2 exhibit overlapping substrate specificities and thus appear to represent redundant activities in skeletal muscle., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation., [RefSeq, PubMed]; The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ80;Q6JIC5;Q96FW7;Q9HB93;Q9UHX2",
        "ec_number_list": [
            {
                "id": "4.2.1.134",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134",
                "type": "external"
            },
            {
                "id": "1.1.1.n12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12",
                "type": "external"
            },
            {
                "id": "4.2.1.107",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107",
                "type": "external"
            },
            {
                "id": "4.2.1.119",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0046848 hydroxyapatite binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0010811 positive regulation of cell-substrate adhesion;GO:0030497 fatty acid elongation;GO:0071529 cementum mineralization",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "B0YJ81-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N442-1",
        "uniprot_id": [
            {
                "id": "GUF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N442",
                "type": "external"
            }
        ],
        "mass": 74328.0,
        "length": 669,
        "protein_name": "Translation factor GUF1, mitochondrial",
        "gene_name": "GUF1",
        "organism": "Human",
        "refseq_name": "translation factor GUF1, mitochondrial isoform 1",
        "refseq_ac": [
            {
                "id": "NP_068746",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068746",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUF1",
        "gene_names_refseq": "DEE40; EF-4; EF4; EIEE40; GUF1",
        "protein_names_uniprotkb": "Translation factor GUF1, mitochondrial; 3.6.5.-; EF-4; Elongation factor 4 homolog; GTPase GUF1; Ribosomal back-translocase",
        "protein_names_refseq": "GTP-binding protein GUF1 homolog; GTPase of unknown function 1; GUF1 homolog, GTPase; elongation factor 4 homolog; ribosomal back-translocase; translation factor GUF1, mitochondrial isoform 1; translation factor GUF1, mitochondrial",
        "tax_id": 9606,
        "disease": "West syndrome (Disease Ontology:DOID:0050562); developmental and epileptic encephalopathy 40 (Disease Ontology:DOID:0080427)",
        "pathway": " (hsa:60558)",
        "pathway_count": 1,
        "publication_count": 43,
        "publication_id_list": "11237011;24366607;24714562;24715725;25418920;25576301;25645385;26154972;26486472;26728094;26758079;26992070;27092003;27600516;27846572;27862975;28904123;29557506;30429286;31844290;32157095;32387766;32488085;32502341;32938616;32983136;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34357683;34509645;34932366;35051231;35580925;36010968;36284347;37217939",
        "class_list": "",
        "function": "Homozygous variant in the GUF1 gene identified in the three siblings with West syndrome., [RefSeq, PubMed]; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner., [UniProtKB, HAMAP]; The structure provides insights into the tRNA-remodeling function of EF-4 on the ribosome and suggests that the displacement of the CCA-end of the A-site tRNA away from the peptidyl transferase center (PTC) is functionally significant., [RefSeq, PubMed]; This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5XKM8;Q9H710;Q9H8U4",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0097177 mitochondrial ribosome binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006412 translation;GO:0045727 positive regulation of translation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q8N442-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13442-1",
        "uniprot_id": [
            {
                "id": "HAP28_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13442",
                "type": "external"
            }
        ],
        "mass": 20630.0,
        "length": 181,
        "protein_name": "28 kDa heat- and acid-stable phosphoprotein",
        "gene_name": "PDAP1",
        "organism": "Human",
        "refseq_name": "28 kDa heat- and acid-stable phosphoprotein",
        "refseq_ac": [
            {
                "id": "NP_055706",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055706",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDAP1; HASPP28",
        "gene_names_refseq": "HASPP28; PAP1; PAP; PDAP1",
        "protein_names_uniprotkb": "28 kDa heat- and acid-stable phosphoprotein; PAP1; PAP; PDGF-associated protein; PDGFA-associated protein 1",
        "protein_names_refseq": "28 kDa heat- and acid-stable phosphoprotein; PDGF-associated protein",
        "tax_id": 9606,
        "disease": "high grade glioma (Disease Ontology:DOID:3070)",
        "pathway": " (hsa:11333);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 72,
        "publication_id_list": "11237011;15302935;17081983;17287340;17322306;17389395;17487921;18088087;18212344;18318008;18452278;18491316;18669648;18767875;19413330;19415658;19608861;19651622;19690332;20068231;20166139;21406692;23186163;23650620;24129315;24275569;25645385;26992070;27448842;27600516;27846572;27862975;28228285;28510447;28832583;28834231;29242379;29393594;29557506;29632711;29656114;30429286;31154438;31844290;31848261;32157095;32350084;32357974;32488085;32897882;32938616;33214551;33537174;33592498;33936100;33968037;33981976;34019948;34087483;34171305;34433824;34509645;35051231;35143476;35251023;35494241;35580925;36010968;36215666;36241641;8692836;8780057",
        "class_list": "",
        "function": "AG1024+U0126 acted synergistically to downregulate 'synergy' genes, especially STAT6 and PDAP1, which displayed significant expression codependency and a common expression pattern linked with other key 'synergy' genes, supporting their predicted role in an STAT6-ERK-nuclear factor kappa beta (NF-kappaB) network. Daunorubicin and PDAP1 loss were synergistic, so PDAP1 is important for the response to this anthracycline., [RefSeq, PubMed]; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB., [UniProtKB]; PDAP-1 as an effecter of PDGF signaling in glioma cells, [RefSeq, PubMed]; RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W5S5;Q92906",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:1904813 ficolin-1-rich granule lumen",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q13442-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WW33-1",
        "uniprot_id": [
            {
                "id": "GTSF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WW33",
                "type": "external"
            }
        ],
        "mass": 19266.0,
        "length": 167,
        "protein_name": "Gametocyte-specific factor 1",
        "gene_name": "GTSF1",
        "organism": "Human",
        "refseq_name": "gametocyte-specific factor 1",
        "refseq_ac": [
            {
                "id": "NP_653195",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653195",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTSF1; FAM112B",
        "gene_names_refseq": "Cue110; FAM112B; GTSF1",
        "protein_names_uniprotkb": "Gametocyte-specific factor 1; Protein FAM112B",
        "protein_names_refseq": "asterix; family with sequence similarity 112, member B; gametocyte-specific factor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:121355)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;18703587;23186163;24190977;24715725;24850846;25576301;26992070;27646122;28218747;28904123;29242379;29437277;29485866;30315122;32357974;32387766;33392160;33691108;33912179;33981976;34509645",
        "class_list": "",
        "function": "Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells., [UniProtKB, UniProtKB]; SYCP1, cTAGE1, and GTSF1 are expressed in cutaneous T-cell lymphoma, but not in normal skin or benign inflammatory dermatoses., [RefSeq, PubMed]; To our knowledge, this report is the first to describe the expression of the human GTSF1 gene in human gametes and preimplantation embryos., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQ60;Q0VGM4;Q8N778",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000049 tRNA binding",
        "go_cellular_component": "GO:0071547 piP-body",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0140965 secondary piRNA processing;GO:0140991 piRNA-mediated gene silencing by mRNA destabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q8WW33-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRV9-1",
        "uniprot_id": [
            {
                "id": "HEBP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRV9",
                "type": "external"
            }
        ],
        "mass": 21097.0,
        "length": 189,
        "protein_name": "Heme-binding protein 1",
        "gene_name": "HEBP1",
        "organism": "Human",
        "refseq_name": "heme-binding protein 1",
        "refseq_ac": [
            {
                "id": "NP_057071",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057071",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEBP1; HBP",
        "gene_names_refseq": "HBP; HEBP1; HEBP",
        "protein_names_uniprotkb": "Heme-binding protein 1; p22HBP",
        "protein_names_refseq": "heme-binding protein 1; p22HBP",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:50865);  (R-HSA-418594);  (R-HSA-444473)",
        "pathway_count": 3,
        "publication_count": 62,
        "publication_id_list": "10640688;11007482;11237011;12120503;12413491;1374236;15623572;15951850;16634148;16923326;17237393;18434541;18577758;20628086;20800521;2161213;21709160;24715725;2534964;25576301;25645385;26154972;26768311;26992070;27452731;2748346;27600516;2834384;28832583;28834231;29508533;29557506;29786170;30779550;30833945;31154438;31453805;31844290;31848261;32157095;32162841;32387766;32488085;32502341;32897882;32938616;32983136;33537174;33592498;33968037;33981976;34171305;34725712;35051231;35580925;36010968;36284347;36580660;38665916;7937899;8015379;8406495",
        "class_list": "",
        "function": "Characterization as a tetrapyrrole-binding protein, [RefSeq, PubMed]; F2L is a chemoattractant peptide promoting calcium mobilization and chemotaxis in dendritic cells and monocytes. [F2L], [RefSeq, PubMed]; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Mouse neutrophils, which like macrophages and dendritic cells express Fpr2, responded to human and mouse F2L in both calcium flux and chemotaxis assays, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Results present a systematic molecular modeling study of the binding properties of murine and human p22HBP protein (heme-binding protein) with four tetrapyrrole ring systems belonging to the heme biosynthetic pathway., [RefSeq, PubMed]; Taken together, these data highlight a role of Hebp1 in progressive neuronal loss during Alzheimer's disease progression. Publication Status: Online-Only, [RefSeq, PubMed]; The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]., [RefSeq]; The functional activity of purified full-length HEBP1 has been evaluated on human formyl peptide receptor (FPR)3-expressing CHO-K1 cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1G2;Q9Y5Z5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0020037 heme binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0070062 extracellular exosome;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007623 circadian rhythm",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q9NRV9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43824-1",
        "uniprot_id": [
            {
                "id": "GTPB6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43824",
                "type": "external"
            }
        ],
        "mass": 56897.0,
        "length": 516,
        "protein_name": "Putative GTP-binding protein 6",
        "gene_name": "GTPBP6",
        "organism": "Human",
        "refseq_name": "putative GTP-binding protein 6",
        "refseq_ac": [
            {
                "id": "NP_036359",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036359",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTPBP6; PGPL",
        "gene_names_refseq": "GTPBP6; PGPL",
        "protein_names_uniprotkb": "Putative GTP-binding protein 6; Pseudoautosomal GTP-binding protein-like",
        "protein_names_refseq": "GTP binding protein 6 (putative); putative GTP-binding protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8225)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "23481700;25418920;26758079;26929215;27600516;27920218;28228285;28514659;28832583;28834231;29242379;29493099;30315122;30429286;31154438;31844290;32157095;32387766;32488085;32897882;32938616;32983136;33264405;33298915;33592498;33691108;33912179;34932366;35051231;35580925;36215666;36284347;9466997",
        "class_list": "",
        "function": "Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes., [RefSeq, PubMed]; This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H0Y2S1;Q53F77;Q5HYX8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0043023 ribosomal large subunit binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:1902775 mitochondrial large ribosomal subunit assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "O43824-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95843-1",
        "uniprot_id": [
            {
                "id": "GUC1C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95843",
                "type": "external"
            }
        ],
        "mass": 23822.0,
        "length": 209,
        "protein_name": "Guanylyl cyclase-activating protein 3",
        "gene_name": "GUCA1C",
        "organism": "Human",
        "refseq_name": "guanylyl cyclase-activating protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005450",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005450",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCA1C; GCAP3",
        "gene_names_refseq": "GCAP3; GUCA1C",
        "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 3; GCAP 3; Guanylate cyclase activator 1C",
        "protein_names_refseq": "GCAP 3; guanylyl cyclase-activating protein 3 isoform 1; guanylyl cyclase-activating protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9626);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10037746;10051575;10564809;10676965;11237011;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12499365;12825937;1356371;1379636;1387789;1436039;14702087;15946941;16274222;16626734;16895762;16908407;17114291;17636946;18803695;19818506;1999465;20430952;20975703;22658984;2540796;2550422;2558719;3006923;3164688;32422965;35328663;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9430683;9459445;9506952",
        "class_list": "",
        "function": "Molecular Properties of Human Guanylate Cyclase-Activating Protein 3 (GCAP3) and Its Possible Association with Retinitis Pigmentosa. Publication Status: Online-Only, [RefSeq, PubMed]; Results report the crystal structure of unmyristoylated human guanylate cyclase-activating protein 3 (GCAP3) with calcium bound., [RefSeq, PubMed]; Role of GUCA1C in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95844;Q9UNM0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008048 calcium sensitive guanylate cyclase activator activity",
        "go_cellular_component": "GO:0097381 photoreceptor disc membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0009966 regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "O95843-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O96004-1",
        "uniprot_id": [
            {
                "id": "HAND1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O96004",
                "type": "external"
            }
        ],
        "mass": 23627.0,
        "length": 215,
        "protein_name": "Heart- and neural crest derivatives-expressed protein 1",
        "gene_name": "HAND1",
        "organism": "Human",
        "refseq_name": "heart- and neural crest derivatives-expressed protein 1",
        "refseq_ac": [
            {
                "id": "NP_004812",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004812",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAND1; BHLHA27; EHAND",
        "gene_names_refseq": "HAND1; Hxt; Thing1; bHLHa27; eHand",
        "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 1; Class A basic helix-loop-helix protein 27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; bHLHa27; eHAND",
        "protein_names_refseq": "class A basic helix-loop-helix protein 27; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart- and neural crest derivatives-expressed protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9421);  (R-HSA-9733709)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "14636580;15095414;15103396;15188014;17891141;19479054;25187301;26783251;29636455;33054971;33428929;34297940;34391879;36695714;38551686;40220298;9931445",
        "class_list": "",
        "function": "Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation., [RefSeq, PubMed]; HAND1 is essential driver of extra-embryonic mesenchyme derivation from human iPSCs-derived trophoblast and binds hominoid-specific regulatory elements., [RefSeq, PubMed]; HAND1 knockdown disrupts trophoblast global gene expression., [RefSeq, PubMed]; Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts., [RefSeq, PubMed]; Novel and deleterious nucleotide variations in the HAND1 gene probably affect miRNA target sites and protein function in pediatric patients with congenital heart disease. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "O96004-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P02100-1",
        "uniprot_id": [
            {
                "id": "HBE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P02100",
                "type": "external"
            }
        ],
        "mass": 16203.0,
        "length": 147,
        "protein_name": "Hemoglobin subunit epsilon",
        "gene_name": "HBE1",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit epsilon",
        "refseq_ac": [
            {
                "id": "NP_005321",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005321",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBE1; HBE",
        "gene_names_refseq": "HBE1; HBE",
        "protein_names_uniprotkb": "Hemoglobin subunit epsilon; Epsilon-globin; Hemoglobin epsilon chain",
        "protein_names_refseq": "epsilon globin; hemoglobin epsilon chain; hemoglobin subunit epsilon; hemoglobin, epsilon 1",
        "tax_id": 9606,
        "disease": "sickle cell anemia (Disease Ontology:DOID:10923)",
        "pathway": " (hsa:3046);  (R-HSA-983231)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "11042108;11062261;11242053;11744692;11751636;11895428;11950885;12032298;12134158;12427746;15020713;15247287;15710388;16054028;1630448;17027967;17196961;19293402;20530532;20627800;20934997;218813;23186163;24366607;26845023;27920218;28514659;31611695;31844290;32157095;32938616;33242839;33936100;33968037;3409321;35580925;35741722;37217939;38083912;6172865;6254663;8662638;8816476;9065479;9230307;9326583;9331217;9422515;9665850;9927674",
        "class_list": "",
        "function": "MicroRNA expression patterns in HbE/beta-thalassemia patients: The passwords to unlock fetal hemoglobin expression in beta-hemoglobinopathies., [RefSeq, PubMed]; Molecular Characterization of Haemoglobin E., [RefSeq, PubMed]; Phenotypic Expression of Known and Novel Hemoglobin A2-Variants, Hemoglobin A2-Mae Phrik [Delta 52(D3) Asp > Gly, HBD:c.158A > G], Associated with Hemoglobin E [Beta 26(B8) Glu > Lys, HBB:c.79G > A] in Thailand. Publication Status: Online-Only, [RefSeq, PubMed]; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin., [UniProtKB]; The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order:  5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FH44",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0072562 blood microparticle;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex",
        "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "P02100-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P07305-1",
        "uniprot_id": [
            {
                "id": "H10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P07305",
                "type": "external"
            }
        ],
        "mass": 20863.0,
        "length": 194,
        "protein_name": "Histone H1.0",
        "gene_name": "H1-0",
        "organism": "Human",
        "refseq_name": "histone H1.0",
        "refseq_ac": [
            {
                "id": "NP_005309",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005309",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-0; H1F0; H1FV",
        "gene_names_refseq": "H1-0; H1.0; H10; H1F0; H1FV",
        "protein_names_uniprotkb": "Histone H1.0; Histone H1'; Histone H1(0)",
        "protein_names_refseq": "H1 histone family member 0; H1.0, H1(0), H1-0; histone H1'; histone H1(0); histone H1.0",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3005);  (R-HSA-140342);  (R-HSA-2559584)",
        "pathway_count": 3,
        "publication_count": 75,
        "publication_id_list": "10318789;10713148;12748178;15149602;15569692;15621527;15655109;15910001;16901784;17043054;17081983;17158953;17242198;17242207;17525332;17938174;18239742;18283539;18491316;18993075;19007248;19029251;19691289;21807893;23964094;25576301;25645921;26375851;27723750;27726376;28510447;29393594;29493099;29557506;29786170;29789417;30429286;30444036;3084796;31154438;31217245;31611695;31844290;31848261;32119511;32157095;32387766;32488085;32938616;32983136;33214551;33238161;33392160;33968037;33981976;34019948;34087483;34171305;34357683;34725712;35051231;35072799;35138101;35154160;35318648;35580925;36284347;36580660;36928068;37217939;37938771;38665916;7374750;9108473;9582379",
        "class_list": "",
        "function": "Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0., [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161). The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (PubMed:7374750)., [UniProtKB, PubMed, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]., [RefSeq]; Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6I0;B4DRD6;Q6FG88;Q8N6R3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031491 nucleosome binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0017053 transcription repressor complex;GO:0016604 nuclear body",
        "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:2000679 positive regulation of transcription regulatory region DNA binding;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "P07305-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08263-1",
        "uniprot_id": [
            {
                "id": "GSTA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08263",
                "type": "external"
            }
        ],
        "mass": 25631.0,
        "length": 222,
        "protein_name": "Glutathione S-transferase A1",
        "gene_name": "GSTA1",
        "organism": "Human",
        "refseq_name": "glutathione S-transferase A1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_665683",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665683",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GSTA1",
        "gene_names_refseq": "GST-epsilon; GST2; GSTA1-1; GSTA1; GTH1",
        "protein_names_uniprotkb": "Glutathione S-transferase A1; 1.11.1.-; 13-hydroperoxyoctadecadienoate peroxidase; 2.5.1.18; 5.3.3.-; Androst-5-ene-3,17-dione isomerase; GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1",
        "protein_names_refseq": "13-hydroperoxyoctadecadienoate peroxidase; GST HA subunit 1; GST class-alpha member 1; S-(hydroxyalkyl)glutathione lyase A1; androst-5-ene-3,17-dione isomerase; glutathione S-alkyltransferase A1; glutathione S-aryltransferase A1; glutathione S-transferase 2; glutathione S-transferase A1 isoform 1; glutathione S-transferase A1; glutathione S-transferase Ha subunit 1; testicular tissue protein Li 80",
        "tax_id": 9606,
        "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841)",
        "pathway": " (hsa:2938);  (R-HSA-156590);  (R-HSA-189483);  (R-HSA-9748787);  (R-HSA-9818027)",
        "pathway_count": 5,
        "publication_count": 136,
        "publication_id_list": "10329152;10421658;10587441;10620517;10644574;10706635;10733945;10783391;10821856;10840050;11023036;11134001;11152686;11309284;11327815;11397817;1157293;11904223;12042665;12211029;12234984;12235164;12435799;12506115;12627223;12697733;1330133;14742434;15001581;15245331;15333749;15448164;15520857;15590625;15728556;15747503;15850391;15893769;16081649;16298388;16314513;16421451;16530731;16548513;16624487;16717136;17234762;17301077;1731620;17942419;17996297;19028565;19273602;19608619;19618965;197968;20083122;20085333;20166139;2018473;20216118;20460467;20606271;21106529;211390;21668448;21723252;21775727;22232210;22444596;22522127;22667998;22823425;22995213;23027624;23096567;23162467;23816837;24041992;24824603;24974183;25002527;2604726;26238318;27100828;27653015;27756681;28985506;29482072;29557506;29693710;29959055;30192525;3031680;3036131;30987408;3138230;31597407;32284348;32601262;33043019;33462411;3372534;33774477;33924269;35793834;36284347;3678589;3770744;3800996;38402986;39063019;4768551;4980931;5767308;657528;6989049;7372607;7959763;8182750;8203914;8226881;8331657;8431482;8591048;8670112;8703034;8812420;9084911;9099726;9132023;9240432;9278457;942489;9551553;9839448",
        "class_list": "",
        "function": "Association of Glutathione Transferase M1, T1, P1 and A1 Gene Polymorphism and Susceptibility to IgA Vasculitis. Publication Status: Online-Only, [RefSeq, PubMed]; Genomic investigation on genes related to mercury metabolism in Amazonian indigenous populations., [RefSeq, PubMed]; Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane., [RefSeq, PubMed]; The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14750;Q5GHF8;Q5SZC1",
        "ec_number_list": [
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "5.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2",
                "type": "external"
            },
            {
                "id": "5.3.99.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2",
                "type": "external"
            },
            {
                "id": "1.11.1.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12",
                "type": "external"
            },
            {
                "id": "1.11.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "5.3.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-",
                "type": "external"
            },
            {
                "id": "1.1.1.270",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270",
                "type": "external"
            },
            {
                "id": "1.1.1.145",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145",
                "type": "external"
            },
            {
                "id": "5.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.210",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210",
                "type": "external"
            },
            {
                "id": "1.20.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "4.4.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0005504 fatty acid binding;GO:0004769 steroid Delta-isomerase activity;GO:0004602 glutathione peroxidase activity;GO:0140104 molecular carrier activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0043651 linoleic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:1901687 glutathione derivative biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P08263-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C5Y9-1",
        "uniprot_id": [
            {
                "id": "H2AB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C5Y9",
                "type": "external"
            }
        ],
        "mass": 12697.0,
        "length": 115,
        "protein_name": "Histone H2A-Bbd type 1",
        "gene_name": "H2AB1",
        "organism": "Human",
        "refseq_name": "histone H2A-Bbd type 1",
        "refseq_ac": [
            {
                "id": "NP_001017990",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017990",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AB1; H2AFB1",
        "gene_names_refseq": "H2A.B.2; H2A.Bbd; H2A.B; H2AB1; H2AFB1",
        "protein_names_uniprotkb": "Histone H2A-Bbd type 1; H2A Barr body-deficient; H2A.Bbd; H2A.B",
        "protein_names_refseq": "H2A Barr body-deficient; H2A histone family member B1; histone H2A-Bbd type 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:474382);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 48,
        "publication_count": 932,
        "publication_id_list": "10029069;10037601;10074426;10080941;10097139;10199952;10204490;10233885;10319874;10323868;10330177;10330422;10347217;10391242;10411933;10425206;10432220;10438626;10471499;10485845;10500157;10548110;10551868;10558993;10562567;10583407;10617663;10655587;1066663;10669743;10706276;10722742;10728666;10734115;10769018;10772813;10775268;10777502;10828826;10831834;10835357;10871633;10873660;10882139;10882850;10921920;10928988;10930409;10956649;10970879;10978333;11010967;11027271;11034064;11050151;11056019;11080158;11103799;11114305;11136970;11136974;11165043;11204562;11242053;11242107;11274398;11278841;11292842;11340163;11340171;11341840;11345900;11356022;11369759;11401442;11410592;11448779;11452016;11454856;11467836;11507205;11532957;11564866;11581164;11590439;11673449;11682626;11684017;11713476;11741541;11744694;11747826;11751582;11756452;11830581;11847229;11867521;118839;11904416;11912130;11934263;11955446;11959841;11973335;11986212;11988739;12086618;12097317;12134156;12140329;12163411;12183469;12189133;12193592;12208845;12242300;12351676;12393752;12419226;12421820;12435631;12454989;12456671;12481029;12483298;12498683;12504854;12514133;12556884;12576332;12612073;12646563;12682017;12700765;12702500;1270801;12718543;12808055;12829629;12832467;12869508;12869583;12909626;12944405;12953102;12959972;1310260;13130130;13130464;14506261;14507994;14517214;14532106;14532133;14536086;14567678;14610093;14631847;14675539;14679213;14691562;14695187;14969726;14991602;15001666;15060161;15064394;15064416;15099518;15105426;15121853;15125634;15164066;15235794;15257289;15276198;15282324;15287722;15294866;15304223;15341901;15343269;15345050;15369670;15369671;15456747;15458641;15469825;15472075;15485929;15510216;15514030;15516265;15542832;15558034;15563468;15643423;15643425;15647753;15655109;15678106;15684396;15701600;15750587;15768032;15774718;15790808;15829968;15861382;15866172;15867264;15882967;15960975;15962837;15986123;16005293;16009131;16046058;16079151;16079795;16087863;16095617;16113099;16123081;16141325;16166375;16169192;16174740;16186106;16186825;16221681;16262255;16263726;16287874;16292313;1630819;16322221;16337592;16357870;16372014;16373483;16380219;16415179;16428440;16431907;16436515;16510874;16514417;16549775;16549788;16567619;16603238;16603771;16612405;16622420;16626623;16628190;16630820;16707490;16751774;16756492;16762929;16799559;16826196;16829525;16858402;16878130;16936726;16949368;16954381;16957777;16980581;17013392;17027977;17052462;17063141;17085592;17130829;17143291;17185360;17199038;17210787;17215844;17254968;17255097;17277772;17320160;17320161;17320163;17332741;17339379;17344414;17344417;17350655;17355984;17363312;17395714;17425515;17425782;17428788;17428831;17433364;17458864;17463000;17495528;17510434;17540598;17540599;17541404;17554337;17562868;1756725;17591702;17603073;17637753;17646674;17660710;17666587;17673620;17680271;17685488;17687327;17690249;17694070;17713478;17716973;17717186;17726088;17761849;17761950;17765224;17823410;17825402;17851529;17875933;17898714;17923702;17965729;17977839;17981954;18003914;18042460;18065497;18066052;18070888;18079182;18082607;18160704;18187655;18211953;18219272;18223688;18256232;18256600;18267069;18280240;18302924;18316480;1831692;18322535;18329190;18346456;18347063;18358809;18365017;18367646;1837051;18378692;18404153;18404694;18411265;18438399;18449172;18476782;18484335;18485871;1849145;18498752;18533032;18535008;18555777;18555778;18571423;18656484;18701449;18718915;18762174;18772889;18776924;18781158;18793328;18805503;18842624;18852463;18945682;18974356;18978028;19001364;19011241;19020303;19026781;19043829;19088198;19098913;19114653;19115252;19146767;19148484;19150886;19167051;19172745;19232136;19234465;1924375;19274700;19295514;19321454;19383337;19383768;19383769;19398495;19398759;19410544;19410545;19451217;19451218;19460168;19462008;19487454;19493659;19509293;19528227;19571010;19571879;19658395;19714243;19718048;19723635;19747919;1975088;19773441;19782034;19783983;19805069;19828817;19834512;19838300;19854132;20008104;20044539;20044541;20062530;20075857;20080577;20080834;20085832;20090754;20123894;20211137;20219941;20220130;2028256;20339092;20351093;20351173;20418909;20442293;20442780;20452968;20453063;20495621;20498280;20523938;20551165;20551166;20566683;20570965;20622854;20630873;20634189;20651253;20661648;20676056;20682797;20801121;20805998;20807650;20818382;20838592;20841325;20871592;20876458;20887958;20937877;20951943;20966048;20974918;21106759;21129147;21151129;21163962;21170310;2118650;21252065;21280156;21316606;21378119;21402699;21427083;21445275;21471526;21489993;21490301;21498573;21515671;21544310;21551231;21555516;21559432;21571218;21573489;21589992;21602795;21654818;21706000;21722948;21725049;21726809;21768289;21774791;21777816;21808299;21808300;2181374;2183031;21835891;21875955;21878914;21899694;21911480;21934649;21940756;2195544;21979375;21979949;21986495;21993314;22012064;22020331;22022377;22046413;22056668;22064703;22064859;22065755;22110129;22131221;22158034;22178396;22186018;22190459;22231400;22265404;22323599;22325352;22336108;22348533;22371011;22398447;22420752;22445173;22466170;22474248;22492511;22545144;22569126;22569366;22569481;22617422;22634325;22658674;22683641;22684280;22704330;22705304;22722852;22751019;22777353;22795134;22848106;22879880;22897851;22922743;22961379;22962365;22982193;23001182;23022729;23145106;23150874;23161542;23172872;23187890;23192763;23219899;23239876;23285124;2330041;23303788;23326524;23361464;23403292;23408615;2342578;23431328;23435229;23466526;23498719;23534758;23555303;23630040;23667505;23679895;23723241;23752590;23755964;23795651;23813966;23846687;23882114;23897426;23906331;2392154;24003239;2405250;24074865;24086155;2409350;24167369;24174538;24252660;24307175;24312487;24336483;24368767;24371278;24379003;24385926;24388755;24531329;24554700;24584857;24586203;24596094;24706756;24735615;24753410;24833601;24854081;24885040;24893886;24901984;24920672;24952918;24973012;24998469;25043025;25101834;25135475;25150861;25240135;2524830;25274305;25296600;25313066;25365482;25394790;25433557;25523424;25542856;25593184;25593309;25633194;25663755;25674852;25689043;2570724;25728767;25728771;25753662;25784553;25784653;25913784;25916849;26010396;26018760;26022416;26055325;26056233;26095805;26139588;26153859;26166249;26204489;26212009;26417681;26462610;26479350;26668317;26686862;26807092;26813693;26977885;27062924;27137657;2721961;27354518;27633282;27661449;27732843;27732854;27806305;27886276;279930;28273063;28404884;28533432;28539435;28581500;28854357;28977666;2900981;29042441;29101237;2919170;29211708;29431622;29557506;29608566;29728366;29729076;29795351;30045876;30122475;30134174;30228260;30327463;3035556;30385408;3045126;3053705;3080684;30898548;30923826;3094007;30980593;30993897;31086175;31289231;3142462;31427381;31746185;31844290;32183950;32188940;32357974;32808929;3281094;32860047;32976585;33009411;33073403;33141586;33264408;33283408;33298899;33298915;33329381;33392160;33608512;33801762;33912179;33936100;33968037;34350706;3484703;3498214;35008676;35138000;35292107;35314832;35851744;36008597;3675579;3677090;38359823;3886654;4054110;500690;6261960;6604055;7391081;7479006;7488013;7501971;7535770;7559524;7588633;7597036;7816143;7831296;7859739;7862113;7906964;7908827;7935485;7937828;7969165;8001816;8016081;8033412;8078588;8097946;8110764;8114934;8159701;8195246;8195709;8197458;8218289;8234276;8242751;8242752;8259215;8284199;8319905;8384717;8407958;8413215;8413306;8419924;8464497;8475094;8490014;8521497;8521498;8528212;8617720;8622669;8622688;8626550;8662714;8674428;8688489;8695841;8710908;874082;8741839;8756721;8757136;8759021;8769649;8774846;8794855;8846784;8846917;8870004;8876171;8878478;8884985;8929543;8939459;8955148;8974401;9006323;9008167;9016654;9030721;9054935;9065481;9118222;9162092;9171241;9177240;9187114;9195981;9201922;9207108;9214382;9218805;9223305;9223306;9272954;9285814;9311981;9321410;9338790;9388265;9427644;9427705;9430628;9450758;9482740;9488439;9490669;9512513;9529249;9564042;9611253;9628874;9642256;9671459;9693032;9705289;9731700;9733514;9733515;9744270;9751710;9768359;9781043;9790531;9804427;9811839;9819412;9824166;9826763;9843217;9843967;9862427;9885572;9890904",
        "class_list": "",
        "function": "Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; H2A.B is a cancer/testis factor involved in the activation of ribosome biogenesis in Hodgkin lymphoma., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015]., [RefSeq]; Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PK90;P98176;Q5TZB2;Q6FG78;Q96PR7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 93.3,
        "record_id": "P0C5Y9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0CG30-1",
        "uniprot_id": [
            {
                "id": "GSTT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0CG30",
                "type": "external"
            }
        ],
        "mass": 27507.0,
        "length": 244,
        "protein_name": "Glutathione S-transferase theta-2B",
        "gene_name": "GSTT2B",
        "organism": "Human",
        "refseq_name": "glutathione S-transferase theta-2B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001074312",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074312",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GSTT2B; GSTT2",
        "gene_names_refseq": "GSTT2B; GSTT2P",
        "protein_names_uniprotkb": "Glutathione S-transferase theta-2B; 2.5.1.18; GST class-theta-2; Glutathione S-transferase theta-2",
        "protein_names_refseq": "GST class-theta-2; glutathione S-transferase theta 2; glutathione S-transferase theta-2B isoform 1",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)",
        "pathway": " (hsa:653689);  (R-HSA-156590)",
        "pathway_count": 2,
        "publication_count": 40,
        "publication_id_list": "10329152;10587441;10783391;11327815;11904223;12042665;12211029;12627223;1417752;14742434;16081649;16298388;16548513;19424424;20083122;20085333;21106529;21668448;22216261;22522127;22676722;23162467;26207597;27600516;28510447;3372534;36580660;3770744;4768551;7789971;8182750;8203914;8331657;8431482;8703034;8761485;8812420;9278457;9551553;9839448",
        "class_list": "",
        "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1417752). Has a sulfatase activity (PubMed:1417752)., [UniProtKB, PubMed]; Results GSTT2B insertion allele was associated with an increased risk of being small for gestational age indicate that, [RefSeq, PubMed]; Results suggest that the presence of the recently described GSTT2B deletion may have a protective effect on the risk of OSCC in the Mixed Ancestry South African population, [RefSeq, PubMed]; Study describes a previously uncharacterized 38-kilo-base (kb) long deletion polymorphism of GSTT2B located within a 61-kb DNA inverted repeat, [RefSeq, PubMed]; The data highlights that GSTT2B copy number variant is not associated with the investigated complex diseases in Italian patients., [RefSeq, PubMed]; The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60665;P30712;Q6IPV7;Q9HD76",
        "ec_number_list": [
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "5.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2",
                "type": "external"
            },
            {
                "id": "5.3.99.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "5.3.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-",
                "type": "external"
            },
            {
                "id": "1.20.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "4.4.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004364 glutathione transferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006749 glutathione metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "P0CG30-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DOY5-1",
        "uniprot_id": [
            {
                "id": "HD101_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DOY5",
                "type": "external"
            }
        ],
        "mass": 435.0,
        "length": 5,
        "protein_name": "Immunoglobulin heavy diversity 1-1",
        "gene_name": "IGHD1-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHD1-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy diversity 1-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "P0DOY5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16401-1",
        "uniprot_id": [
            {
                "id": "H15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16401",
                "type": "external"
            }
        ],
        "mass": 22580.0,
        "length": 226,
        "protein_name": "Histone H1.5",
        "gene_name": "H1-5",
        "organism": "Human",
        "refseq_name": "histone H1.5",
        "refseq_ac": [
            {
                "id": "NP_005313",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005313",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-5; H1F5; HIST1H1B",
        "gene_names_refseq": "H1-5; H1.5; H1B; H1F5; H1s-3; H1; HIST1H1B",
        "protein_names_uniprotkb": "Histone H1.5; Histone H1a; Histone H1b; Histone H1s-3",
        "protein_names_refseq": "H1 histone family, member 5; histone 1, H1b; histone H1.5; histone H1a; histone H1b; histone H1s-3; histone cluster 1 H1 family member b; histone cluster 1, H1b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3009);  (R-HSA-140342);  (R-HSA-2559584)",
        "pathway_count": 3,
        "publication_count": 113,
        "publication_id_list": "10318789;10713148;10997781;11746507;12408966;12748178;15149602;15569692;15595731;15621527;15655109;15910001;15911621;16083285;16377619;16901784;16959974;17043054;17081983;17158953;17242198;17242207;17938174;18212344;18239742;18283539;18452278;18578522;18669648;19007248;19029251;19136008;19413330;19552482;19608861;19651622;19664995;19690332;19691289;20068231;20305658;20439994;21081667;21406692;21807893;22223895;23186163;23964094;24275569;24715725;25418920;25576301;2613692;26154972;26758079;27452731;27726376;28228285;28539972;28832583;28904123;29242379;29317506;29508533;29557506;29786170;30154464;30315122;30444036;31020640;31154438;31217245;31611695;31844290;31848261;32157095;32161166;32350084;32387766;32522876;32938616;32983136;33028027;33141586;33214551;33221335;33298915;33392160;33592498;34019948;34171305;34357683;34433824;34509645;34545082;34561969;34961760;35051231;35154160;35251023;35526384;35561310;35580925;36241641;36284347;37217939;37938771;38665916;38755141;40516528;40914422;9031620;9108473",
        "class_list": "",
        "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (By similarity). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:40516528). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]; How Human H1 Histone Recognizes DNA. Publication Status: Online-Only, [RefSeq, PubMed]; Nano-Surveillance: Tracking Individual Molecules in a Sea of Chromatin. Review article, [RefSeq, PubMed]; The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14529;Q3MJ42",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042826 histone deacetylase binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0000792 heterochromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "P16401-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P25092-1",
        "uniprot_id": [
            {
                "id": "GUC2C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P25092",
                "type": "external"
            }
        ],
        "mass": 123403.0,
        "length": 1073,
        "protein_name": "Guanylyl cyclase C",
        "gene_name": "GUCY2C",
        "organism": "Human",
        "refseq_name": "guanylyl cyclase C precursor",
        "refseq_ac": [
            {
                "id": "NP_004954",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004954",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCY2C; GUC2C; STAR",
        "gene_names_refseq": "DIAR6; GC-C; GCC; GUC2C; GUCY2C; HSER; MECIL; MUCIL; STAR",
        "protein_names_uniprotkb": "Guanylyl cyclase C; 4.6.1.2; GC-C; Heat-stable enterotoxin receptor; Intestinal guanylate cyclase; STA receptor; hSTAR",
        "protein_names_refseq": "STA receptor; guanylyl cyclase C precursor; guanylyl cyclase C; heat-stable enterotoxin receptor; intestinal guanylate cyclase",
        "tax_id": 9606,
        "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); congenital diarrhea 6 (Disease Ontology:DOID:0060780); obesity (Disease Ontology:DOID:9970); intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency (MONDO:MONDO:0013843)",
        "pathway": " (hsa:2984);  (R-HSA-8935690);  (R-HSA-8942233)",
        "pathway_count": 3,
        "publication_count": 33,
        "publication_id_list": "10.1101/2023.09.13.557529;11123935;11950846;15951572;1680854;1718270;17344846;19413330;19960363;22069677;22436048;22521417;23269669;29557506;31154438;31530632;32157095;32387766;32488085;34157861;34185709;34508047;35051231;36241641;36548082;37535399;37591971;7902563;8095028;8381596;8390480;8605253;9079676",
        "class_list": "",
        "function": "Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Intestinal Guanylate Cyclase-C mRNA Expression in Duodenum and Colon of Children., [RefSeq, PubMed]; Intestinal neuropod cell GUCY2C regulates visceral pain. Publication Status: Online-Only, [RefSeq, PubMed]; Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction., [RefSeq, PubMed]; Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3. Publication Status: Online-Only, [RefSeq, PubMed]; Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMY6",
        "ec_number_list": [
            {
                "id": "4.6.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0015643 toxic substance binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "P25092-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P49915-1",
        "uniprot_id": [
            {
                "id": "GUAA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P49915",
                "type": "external"
            }
        ],
        "mass": 76715.0,
        "length": 693,
        "protein_name": "GMP synthase [glutamine-hydrolyzing]",
        "gene_name": "GMPS",
        "organism": "Human",
        "refseq_name": "GMP synthase [glutamine-hydrolyzing]",
        "refseq_ac": [
            {
                "id": "NP_003866",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003866",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GMPS",
        "gene_names_refseq": "GATD7; GMPS",
        "protein_names_uniprotkb": "GMP synthase [glutamine-hydrolyzing]; 6.3.5.2; GMP synthetase; Glutamine amidotransferase",
        "protein_names_refseq": "GMP synthase [glutamine-hydrolyzing]; GMP synthase; GMP synthetase; MLL/GMPS fusion protein; glutamine amidotransferase; guanine monophosphate synthase; guanine monophosphate synthetase; guanosine 5'-monophosphate synthase; testicular tissue protein Li 82",
        "tax_id": 9606,
        "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:8833);  (R-HSA-73817);  (R-HSA-9748787)",
        "pathway_count": 3,
        "publication_count": 175,
        "publication_id_list": "10.1101/2023.09.13.557529;10840050;10958654;11096114;11110714;11381136;12435799;12450384;12697733;14529546;15747503;15786719;15850391;1592113;16530731;16717136;17224163;17301077;17924679;17996297;18388293;18609073;18669648;18767875;19413330;19608861;19651622;19664995;1967654;197968;20068231;20112406;20216118;211390;21320556;21406692;2147474;21723252;2183217;21960835;22424782;22444596;22869377;23096567;23186163;23301498;23816837;24366607;24714562;24715725;24824603;24974183;25418920;25576301;25645385;25810538;25892735;26154972;26238318;26811146;26890086;26992070;27600516;27846572;27862975;27920218;28063628;28159928;28218747;28228285;28510447;28514659;28832583;28834231;28855257;28904123;29242379;29351928;29393594;29437277;29482072;29493099;29508533;29557506;29632046;29632711;29786170;29788244;30315122;30410026;30429286;30524438;30779550;30833945;30987408;31092671;31154438;31217245;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32414791;32488085;32502341;32870666;32897882;32938616;32983136;33091337;33141586;33214551;33298915;33392160;33592498;33633747;33649833;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34433824;34509645;34520390;34561969;34725712;34932366;35051231;35138101;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37074911;37217939;38665916;39894887;40596516;40914422;4348202;4726295;5767308;657528;6989049;762062;7706277;7903306;8089153;8110788;8226881;8366112;8380692;8567683;8670112;9099726;9132023;942489",
        "class_list": "",
        "function": "Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate., [UniProtKB, PubMed]; Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway., [RefSeq, PubMed]; In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]., [RefSeq]; Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The GMPS SNP rs61750370 may be a reliable risk factor for extreme 6MMP preferential metabolism in patients with inflammatory bowel disease, [RefSeq, PubMed]; The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis., [RefSeq, PubMed]; Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K639;B4DXV7;F8W720",
        "ec_number_list": [
            {
                "id": "6.3.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0003921 GMP synthase activity;GO:0003922 GMP synthase (glutamine-hydrolyzing) activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0009168 purine ribonucleoside monophosphate biosynthetic process;GO:0006177 GMP biosynthetic process;GO:0009113 purine nucleobase biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 18.5,
        "record_id": "P49915-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P51841-1",
        "uniprot_id": [
            {
                "id": "GUC2F_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P51841",
                "type": "external"
            }
        ],
        "mass": 124850.0,
        "length": 1108,
        "protein_name": "Retinal guanylyl cyclase 2",
        "gene_name": "GUCY2F",
        "organism": "Human",
        "refseq_name": "retinal guanylyl cyclase 2",
        "refseq_ac": [
            {
                "id": "NP_001513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001513",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCY2F; GUC2F; RETGC2",
        "gene_names_refseq": "CYGF; GC-F; GUC2DL; GUC2F; GUCY2F; RETGC-2; ROS-GC2",
        "protein_names_uniprotkb": "Retinal guanylyl cyclase 2; 4.6.1.2; GC-F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; RETGC-2; ROS-GC2; Rod outer segment membrane guanylate cyclase 2",
        "protein_names_refseq": "guanylate cyclase 2D-like, membrane (retina-specific); guanylate cyclase F; retinal guanylyl cyclase 2; rod outer segment membrane guanylate cyclase 2",
        "tax_id": 9606,
        "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)",
        "pathway": " (hsa:2986);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "10037746;10051575;10564809;10676965;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12499365;12825937;1356371;1379636;1387789;1436039;14702087;15946941;16274222;16895762;16908407;16941478;16959974;17114291;17344846;17636946;17868328;18803695;19351817;19818506;1999465;20430952;20975703;22658984;23033978;2540796;2550422;2558719;26375851;29515371;29557506;29632711;3006923;3164688;34537244;35051231;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9430683;9459445;9506952",
        "class_list": "",
        "function": "Mutants of GC-activating protein 2 modulated ROS-GC2 in a manner different from their action on ROS-GC1 indicating that the Ca2+ sensitivity of the Ca2+ sensor is controlled by the mode of target-sensor interaction., [RefSeq, PubMed]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]; Results show GUCY2F gene was implicated in the pathogenesis of breast, lung, and pancreatic cancers and it may be useful targets for diagnostic and therapeutic intervention in selected patients., [RefSeq, PubMed]; Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase., [RefSeq, PubMed]; The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UJF1",
        "ec_number_list": [
            {
                "id": "4.6.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0097381 photoreceptor disc membrane;GO:0005640 nuclear outer membrane;GO:0042622 photoreceptor outer segment membrane;GO:0120200 rod photoreceptor outer segment",
        "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0022400 regulation of opsin-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "P51841-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02539-1",
        "uniprot_id": [
            {
                "id": "H11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02539",
                "type": "external"
            }
        ],
        "mass": 21842.0,
        "length": 215,
        "protein_name": "Histone H1.1",
        "gene_name": "H1-1",
        "organism": "Human",
        "refseq_name": "histone H1.1",
        "refseq_ac": [
            {
                "id": "NP_005316",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005316",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-1; H1F1; HIST1H1A",
        "gene_names_refseq": "H1-1; H1.1; H1A; H1F1; HIST1H1A; HIST1",
        "protein_names_uniprotkb": "Histone H1.1; Histone H1a",
        "protein_names_refseq": "H1 histone family, member 1; histone 1, H1a; histone H1.1; histone H1a; histone cluster 1 H1 family member a; histone cluster 1, H1a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3024);  (R-HSA-140342);  (R-HSA-2559584)",
        "pathway_count": 3,
        "publication_count": 77,
        "publication_id_list": "10318789;10713148;11130728;12408966;12748178;14985337;15149602;15569692;15621527;15655109;15910001;15911621;16901784;17043054;17158953;17242198;17242207;17287340;17938174;18239742;18283539;19029251;19882353;20068231;20551309;21081667;21807893;22121020;23783831;23964094;24714562;25645385;25802875;26154972;26375851;26552660;26758079;2759094;27726376;28228285;28834231;29242379;29493099;29557506;29786170;29789417;30154464;30315122;30429286;31611695;31844290;31998317;32157095;32161166;32350084;32387766;32488085;32522876;32983136;33091337;33214551;33298915;33392160;33592498;33717175;33936100;34087483;34171305;34545082;34663856;34961760;35051231;35251023;37217939;7499230;8003976;9108473",
        "class_list": "",
        "function": "Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants. Publication Status: Online-Only, [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:11130728). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:11130728). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MJ34",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0031982 vesicle;GO:0000785 chromatin",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0006334 nucleosome assembly;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q02539-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02747-1",
        "uniprot_id": [
            {
                "id": "GUC2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02747",
                "type": "external"
            }
        ],
        "mass": 12388.0,
        "length": 115,
        "protein_name": "Guanylin",
        "gene_name": "GUCA2A",
        "organism": "Human",
        "refseq_name": "guanylin precursor",
        "refseq_ac": [
            {
                "id": "NP_291031",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291031",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCA2A; GUCA2",
        "gene_names_refseq": "GCAP-I; GUCA2A; GUCA2; STARA",
        "protein_names_uniprotkb": "Guanylin; GCAP-I; Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Guanylate cyclase-activating protein I",
        "protein_names_refseq": "guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable); guanylate cyclase-activating protein 1; guanylate cyclase-activating protein I; guanylin precursor; prepro-guanylin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2980);  (R-HSA-8935690)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "10.1101/2023.09.13.557529;11123935;12707255;1327879;1409606;15951572;19960363;23269669;27108812;27125248;28467828;29289697;29557506;29789417;32037952;33592498;7892222;7902563;7947768;8095028;8390480;9079676",
        "class_list": "",
        "function": "APC-beta-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis., [RefSeq, PubMed]; Both guanylin and uroguanylin trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity., [RefSeq, PubMed]; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins., [UniProtKB]; Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes., [RefSeq, PubMed]; Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 9704,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity;GO:0030250 guanylate cyclase activator activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q02747-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02846-1",
        "uniprot_id": [
            {
                "id": "GUC2D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02846",
                "type": "external"
            }
        ],
        "mass": 120059.0,
        "length": 1103,
        "protein_name": "Retinal guanylyl cyclase 1",
        "gene_name": "GUCY2D",
        "organism": "Human",
        "refseq_name": "retinal guanylyl cyclase 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_000171",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000171",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCY2D; CORD6; GUC1A4; GUC2D; RETGC1; RETGC",
        "gene_names_refseq": "CACD1; CACD; CG-E; CORD5; CORD6; CSNB1I; CYGD; GUC1A4; GUC2D; GUCY2D; LCA1; LCA; RCD2; RETGC-1; ROS-GC1; ROSGC; retGC",
        "protein_names_uniprotkb": "Retinal guanylyl cyclase 1; 4.6.1.2; CG-E; Guanylate cyclase 2D, retinal; RETGC-1; ROS-GC; Rod outer segment membrane guanylate cyclase",
        "protein_names_refseq": "ROS-GC; central areolar choroidal dystrophy; cone rod dystrophy 6; guanylate cyclase 2D, membrane (retina-specific); retinal guanylate cyclase 1; retinal guanylyl cyclase 1 precursor; retinal guanylyl cyclase 1; rod outer segment membrane guanylate cyclase",
        "tax_id": 9606,
        "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); Leber congenital amaurosis 1 (Disease Ontology:DOID:0110078); congenital stationary night blindness 2A (Disease Ontology:DOID:0110871); cone-rod dystrophy 6 (Disease Ontology:DOID:0111011); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber congenital amaurosis (Disease Ontology:DOID:14791); choroidal sclerosis (Disease Ontology:DOID:980); night blindness, congenital stationary, type1i (MONDO:MONDO:0032811)",
        "pathway": " (hsa:3000);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10037746;10051575;10564809;10676965;11035546;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12365911;12499365;12552567;12825937;1356371;1379636;1387789;1436039;14702087;15111605;15123990;15946941;16123401;16274222;16895762;16908407;17114291;17344846;17636946;17724218;18332321;18487367;18803695;19413330;19818506;1999465;20430952;20517349;20975703;21078983;21552474;21602930;21928830;22194653;22658984;22695961;23481700;23734073;24480840;2540796;2550422;25515582;2558719;26100624;27475985;29557506;29559409;3006923;30319355;31092671;31154438;3164688;31848261;32387766;35051231;36490268;36509996;37327959;37775646;38253038;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7806240;7912093;7983048;8494894;8626439;8706659;8812493;8944027;9119368;9353336;9391039;9430683;9459445;9506952;9600905;9618177;9683616;9888789",
        "class_list": "",
        "function": "A natural history study of autosomal dominant GUCY2D-associated cone-rod dystrophy., [RefSeq, PubMed]; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:15123990, PubMed:21928830, PubMed:26100624, PubMed:30319355, PubMed:9600905). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Comprehensive Genotyping and Phenotyping Analysis of GUCY2D-Associated Rod- and Cone-Dominated Dystrophies., [RefSeq, PubMed]; Phenotypic characterization of autosomal dominant progressive cone dystrophies associated with a heterozygous variant c.2512C>T of GUCY2D gene in a large kindred., [RefSeq, PubMed]; The impact of modifier genes on cone-rod dystrophy heterogeneity: An explorative familial pilot study and a hypothesis on neurotransmission impairment. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6LEA7",
        "ec_number_list": [
            {
                "id": "4.6.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0097381 photoreceptor disc membrane;GO:0001750 photoreceptor outer segment;GO:0005640 nuclear outer membrane",
        "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0022400 regulation of opsin-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q02846-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14520-1",
        "uniprot_id": [
            {
                "id": "HABP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14520",
                "type": "external"
            }
        ],
        "mass": 62672.0,
        "length": 560,
        "protein_name": "Factor VII-activating protease",
        "gene_name": "HABP2",
        "organism": "Human",
        "refseq_name": "factor VII-activating protease isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001171131",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171131",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HABP2; HGFAL",
        "gene_names_refseq": "FSAP; HABP2; HABP; HGFAL; NMTC5; PHBP; PHBSP",
        "protein_names_uniprotkb": "Factor VII-activating protease; 3.4.21.-; FSAP; FVII activator; Hepatocyte growth factor activator-like protein; Hyaluronan-binding protein 2; PHBP; PHBSP; Plasma hyaluronan-binding protein; Plasma hyaluronan-binding serine protease",
        "protein_names_refseq": "FVII activator; factor VII activating protein; factor VII-activating protease isoform 2; factor VII-activating protease; factor seven-activating protease; hepatocyte growth factor activator-like protein; hyaluronic acid binding protein 2; plasma hyaluronan binding protein; plasma hyaluronan-binding serine protease",
        "tax_id": 9606,
        "disease": "thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969); thyroid cancer, nonmedullary, 5 (MONDO:MONDO:0014682)",
        "pathway": " (hsa:3026)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10754382;11217080;11379758;12138371;12578864;15486068;23090970;24497464;26222560;26581001;26581002;26581003;26581004;26581005;26691890;26745718;26832773;27154966;27418631;28418605;29557506;30459171;31154438;32488085;32983136;34357683;34973499;34992208;36265411;36430180;38253038;39894887;40596516;8827452",
        "class_list": "glycogene",
        "function": "Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly (PubMed:11217080). It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form (PubMed:10754382, PubMed:11217080). Activates coagulation factor VII (Probable). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560)., [UniProtKB, PubMed, PubMed, PubMed]; Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis., [RefSeq, PubMed]; FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]; FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion. Publication Status: Online-Only, [RefSeq, PubMed]; FSAP functions in initiation and progression of hepatic fibrosis Review article, [RefSeq, PubMed]; Factor VII activating protease (FSAP) is not essential in the pathophysiology of angioedema in patients with C1 inhibitor deficiency., [RefSeq, PubMed]; This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 842,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 4,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K467;B7Z8U5;F5H5M6;O00663",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005539 glycosaminoglycan binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q14520-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q58FF8-1",
        "uniprot_id": [
            {
                "id": "H90B2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q58FF8",
                "type": "external"
            }
        ],
        "mass": 44349.0,
        "length": 381,
        "protein_name": "Putative heat shock protein HSP 90-beta 2",
        "gene_name": "HSP90AB2P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HSP90AB2P; HSP90BB",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative heat shock protein HSP 90-beta 2; Heat shock protein 90-beta b; Heat shock protein 90Bb",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 36,
        "publication_id_list": "16269234;17081983;20934997;22645359;23481700;24190977;24366607;25576301;25645385;25892735;26154972;26375851;26758079;27600516;28228285;28832583;28904123;29242379;29769354;30315122;30410026;30484775;30524438;30779550;31154438;32387766;33091337;33214551;33912179;33968037;34019948;34357683;35580925;36010968;36241641;37217939",
        "class_list": "",
        "function": "Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0034605 cellular response to heat;GO:0050821 protein stabilization;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q58FF8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T447-1",
        "uniprot_id": [
            {
                "id": "HECD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T447",
                "type": "external"
            }
        ],
        "mass": 97113.0,
        "length": 861,
        "protein_name": "E3 ubiquitin-protein ligase HECTD3",
        "gene_name": "HECTD3",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase HECTD3",
        "refseq_ac": [
            {
                "id": "NP_078878",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078878",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HECTD3",
        "gene_names_refseq": "HECTD3",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HECTD3; 2.3.2.26; HECT domain-containing protein 3; HECT-type E3 ubiquitin transferase HECTD3",
        "protein_names_refseq": "E3 ubiquitin-protein ligase HECTD3; HECT domain containing E3 ubiquitin protein ligase 3; HECT-type E3 ubiquitin transferase HECTD3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79654);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "11062501;11350924;12646216;14734113;15224091;15224092;15571818;16595681;16849449;16954532;18194665;18662542;19028597;19352404;19452197;19489725;19851334;19874575;19940261;22223895;2261476;23186163;23358872;23481700;24714562;25505266;25892735;26154972;26375851;26728094;26992070;27846572;27862975;27920218;28218747;28228285;28510447;28636940;28716524;28832583;28904123;29242379;29437277;29557506;29786170;30429286;30484775;30833945;31154438;31637449;31844290;31848261;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33912179;33968037;34171305;34185709;34509645;35051231;35154160;35494241;35561310;35580925;36010968;36088509;36241641;36284347;37422058;37938771;9380723;9668046",
        "class_list": "",
        "function": "All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara., [RefSeq, PubMed]; E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer., [RefSeq, PubMed]; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity)., [UniProtKB, UniProtKB, PubMed]; HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway., [RefSeq, PubMed]; HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway., [RefSeq, PubMed]; Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis., [RefSeq, PubMed]; The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]., [RefSeq]; This review describes the progress in the recent studies of HECTD3 in cancer and other diseases. [review] Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPV7;B3KRH4;Q5T448;Q9H783",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019905 syntaxin binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q5T447-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6B0K9-1",
        "uniprot_id": [
            {
                "id": "HBM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6B0K9",
                "type": "external"
            }
        ],
        "mass": 15618.0,
        "length": 141,
        "protein_name": "Hemoglobin subunit mu",
        "gene_name": "HBM",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit mu",
        "refseq_ac": [
            {
                "id": "NP_001003938",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003938",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBM; HBAP2",
        "gene_names_refseq": "HBAP2; HBK; HBM",
        "protein_names_uniprotkb": "Hemoglobin subunit mu; Hemoglobin mu chain; Mu-globin",
        "protein_names_refseq": "alpha globin pseudogene 2; hemoglobin mu chain; hemoglobin subunit mu; hemoglobin, alpha pseudogene 2; hemoglobin, mu; mu-globin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3042)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "15855277;16728641;19199228;29557506;31154438;35580925",
        "class_list": "",
        "function": "HbM Saskatoon is normally a harmless variant. However, in conjunction with severe pneumonia, we assume that it did not only affect clinical evaluation, but also exacerbated pneumonia by reducing the oxygen binding capacity., [RefSeq, PubMed]; Results suggest the human genome encodes a previously unrecognized globin member of the avian alpha-D family that is transcribed in a highly regulated pattern in erythroid cells, [RefSeq, PubMed]; The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex",
        "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6B0K9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z4Q2-1",
        "uniprot_id": [
            {
                "id": "HEAT3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z4Q2",
                "type": "external"
            }
        ],
        "mass": 74583.0,
        "length": 680,
        "protein_name": "HEAT repeat-containing protein 3",
        "gene_name": "HEATR3",
        "organism": "Human",
        "refseq_name": "HEAT repeat-containing protein 3 isoform a",
        "refseq_ac": [
            {
                "id": "NP_891552",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891552",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR3",
        "gene_names_refseq": "DBA21; HEATR3; SYO1; hsSyo1",
        "protein_names_uniprotkb": "HEAT repeat-containing protein 3; Symportin Syo1; hsSyo1",
        "protein_names_refseq": "HEAT repeat-containing protein 3 isoform a; HEAT repeat-containing protein 3; symportin 1; symportin Syo1",
        "tax_id": 9606,
        "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339); Diamond-Blackfan anemia 21 (MONDO:MONDO:0031071)",
        "pathway": " (hsa:55027)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;18452278;20058876;20068231;22299025;22544926;23186163;23301498;23481700;23615072;24275569;24715725;25418920;25505266;25645385;26154972;26375851;26929215;26992070;27846572;27920218;28063628;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30315122;30379171;30429286;30524438;30833945;31154438;31530632;31844290;32157095;32357974;32387766;32502341;32938616;32983136;33141586;33214551;33298915;33592498;33968037;34019948;34171305;34509645;34561969;35051231;35213692;35580925;36010968;36241641;36284347;37291423;37938771;38253038;40596516;40914422",
        "class_list": "",
        "function": "Data indicate that HEATR3 plays a positive role in NOD2-mediated NF-kappaB signaling., [RefSeq, PubMed]; HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia., [RefSeq, PubMed]; Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5) (PubMed:35213692). Required for proper erythrocyte maturation (PubMed:35213692)., [UniProtKB, PubMed]; The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1N4;Q8N525;Q8WV56;Q96CC9;Q9NWN7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051082 unfolded protein binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0042273 ribosomal large subunit biogenesis;GO:0006606 protein import into nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q7Z4Q2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UQ5-1",
        "uniprot_id": [
            {
                "id": "GTSC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UQ5",
                "type": "external"
            }
        ],
        "mass": 15623.0,
        "length": 136,
        "protein_name": "Gilles de la Tourette syndrome chromosomal region candidate gene 1 protein",
        "gene_name": "GTSCR1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "GTSCR1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Gilles de la Tourette syndrome chromosomal region candidate gene 1 protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "12682296;28904123",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J3KSW9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q86UQ5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TDS4-1",
        "uniprot_id": [
            {
                "id": "HCAR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TDS4",
                "type": "external"
            }
        ],
        "mass": 41850.0,
        "length": 363,
        "protein_name": "Hydroxycarboxylic acid receptor 2",
        "gene_name": "HCAR2",
        "organism": "Human",
        "refseq_name": "hydroxycarboxylic acid receptor 2",
        "refseq_ac": [
            {
                "id": "NP_808219",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808219",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCAR2; GPR109A; HCA2; HM74A; NIACR1",
        "gene_names_refseq": "GPR109A; HCA2; HCAR2; HM74a; HM74b; NIACR1; PUMAG; Puma-g",
        "protein_names_uniprotkb": "Hydroxycarboxylic acid receptor 2; G protein-coupled receptor 109A; G protein-coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor",
        "protein_names_refseq": "G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; hydroxycarboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:338442);  (R-HSA-3296197);  (R-HSA-373076);  (R-HSA-418594)",
        "pathway_count": 4,
        "publication_count": 51,
        "publication_id_list": "11007482;12044878;12120503;12522134;12524422;12646212;12955148;14617636;15141213;15280385;15326175;15929991;15951850;16018973;16540462;1656963;16634148;16754668;16844083;16923326;17139494;17339491;17462861;17876302;17932499;18434541;18577758;18588883;18952058;19047060;19561068;21454438;21796212;2263478;2534964;25690651;2748346;2834384;28467828;37578011;37932263;37933650;38007572;7498464;7568007;7689702;7775459;7937899;7946354;8015379;8406495",
        "class_list": "",
        "function": "Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide., [UniProtKB, PubMed]; Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death., [RefSeq, PubMed]; HM74b has high similarity to HM74 is a receptor for nicotinic acid [HM74b], [RefSeq, PubMed]; Our results provided direct evidence indicating that HM74A, but not HM74, was sufficient to mediate anti-lipolytic effect of niacin in adipose tissue., [RefSeq, PubMed]; Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a. Publication Status: Online-Only, [RefSeq, PubMed]; Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. Publication Status: Online-Only, [RefSeq, PubMed]; [GPR109A partly mediates inhibitory effects of beta-hydroxybutyric acid on lung adenocarcinoma cell proliferation, migration and invasion]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJL5;A7LGG3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0070553 nicotinic acid receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0050995 negative regulation of lipid catabolic process;GO:0033031 positive regulation of neutrophil apoptotic process;GO:0001781 neutrophil apoptotic process;GO:0070165 positive regulation of adiponectin secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q8TDS4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000100001001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TF76-1",
        "uniprot_id": [
            {
                "id": "HASP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TF76",
                "type": "external"
            }
        ],
        "mass": 88495.0,
        "length": 798,
        "protein_name": "Serine/threonine-protein kinase haspin",
        "gene_name": "HASPIN",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase haspin",
        "refseq_ac": [
            {
                "id": "NP_114171",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114171",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HASPIN; GSG2",
        "gene_names_refseq": "GSG2; HASPIN",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase haspin; 2.7.11.1; Germ cell-specific gene 2 protein; H-haspin; Haploid germ cell-specific nuclear protein kinase",
        "protein_names_refseq": "H-haspin; germ cell associated 2, haspin; germ cell-specific gene 2 protein; haploid germ cell-specific nuclear protein kinase; serine/threonine-protein kinase haspin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83903)",
        "pathway_count": 1,
        "publication_count": 46,
        "publication_id_list": "11228240;11311556;15681610;16565220;17084365;17344846;17525332;18669648;19664994;19690332;19691289;19918049;19918057;20068231;20705812;20929775;21397507;21658950;21804608;23186163;23481700;24714562;25576301;26992070;28228285;28832583;28904123;29242379;29351928;29393594;29493099;29632046;30315122;31844290;32161166;32387766;32897882;32938616;33936100;33968037;35051231;35972887;37537694;38441546;38613588;38759367",
        "class_list": "",
        "function": "GSG2 facilitates the progression of human breast cancer through MDM2-mediated ubiquitination of E2F1. Publication Status: Online-Only, [RefSeq, PubMed]; GSG2 promotes progression of human endometrial cancer by regulating PD-1/PD-L1 expression via PI3K-AKT pathway., [RefSeq, PubMed]; GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway., [RefSeq, PubMed]; Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3alpha-p27 cascade., [RefSeq, PubMed]; Haspin is required to maintain centromeric cohesion during mitosis., [RefSeq, PubMed]; Knockdown of GSG2 inhibits the development and progression of non-small cell lung cancer in vitro and in vivo., [RefSeq, PubMed]; Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5U5K3;Q96MN1;Q9BXS7",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle",
        "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0007094 mitotic spindle assembly checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q8TF76-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92522-1",
        "uniprot_id": [
            {
                "id": "H1X_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92522",
                "type": "external"
            }
        ],
        "mass": 22487.0,
        "length": 213,
        "protein_name": "Histone H1.10",
        "gene_name": "H1-10",
        "organism": "Human",
        "refseq_name": "histone H1.10",
        "refseq_ac": [
            {
                "id": "NP_006017",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006017",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-10; H1FX",
        "gene_names_refseq": "H1-10; H1.10; H1FX; H1X",
        "protein_names_uniprotkb": "Histone H1.10; Histone H1x",
        "protein_names_refseq": "H1 histone family member X; histone H1.10; histone H1x",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8971)",
        "pathway_count": 1,
        "publication_count": 100,
        "publication_id_list": "11237011;16006241;17081983;17287340;17322306;17924679;18212344;18566446;18669648;19007248;19117535;19608861;19651622;19664995;19690332;19691289;19710015;20068231;20112406;21224338;21406692;22223895;22898188;23186163;24275569;24714562;24715725;25576301;25645385;25645921;26154972;26728094;26992070;27600516;27846572;27862975;28218747;28228285;28832583;28834231;29242379;29331515;29351928;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30192525;30429286;30524438;30779550;31154438;31222486;31611695;31844290;31848261;31937595;32161166;32265295;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33238161;33392160;33592498;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34229054;34405274;34509645;35051231;35251023;35318648;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38261975;38609001;40516528;40596516;8964515",
        "class_list": "",
        "function": "Comparison of primary aa sequence with other human H1 subtypes, and H1x from different species, generation of specific antibody, expression in different cell lines, [RefSeq, PubMed]; Genomic profiling of six human somatic histone H1 variants denotes that H1X accumulates at recently incorporated transposable elements., [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161, PubMed:40516528)., [UniProtKB, PubMed, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]., [RefSeq]; MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q92522-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96MM7-1",
        "uniprot_id": [
            {
                "id": "H6ST2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96MM7",
                "type": "external"
            }
        ],
        "mass": 69130.0,
        "length": 605,
        "protein_name": "Heparan-sulfate 6-O-sulfotransferase 2",
        "gene_name": "HS6ST2",
        "organism": "Human",
        "refseq_name": "heparan-sulfate 6-O-sulfotransferase 2 isoform L",
        "refseq_ac": [
            {
                "id": "NP_001070656",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070656",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HS6ST2; PSEC0092",
        "gene_names_refseq": "HS6ST2; MRXSPM",
        "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 2; 2.8.2.-; HS6ST-2",
        "protein_names_refseq": "HS6ST-2; heparan-sulfate 6-O-sulfotransferase 2 isoform L",
        "tax_id": 9606,
        "disease": "Paganini-Miozzo syndrome (Disease Ontology:DOID:0111843)",
        "pathway": " (hsa:90161);  (R-HSA-2022928)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10318803;10639137;10644753;10677367;10716625;11087757;11169766;11237011;11274177;11279150;11390981;12138164;12492399;15082721;15607426;16303743;16343444;20554947;21443520;21700882;23481700;23584533;24715725;25645385;28132690;28148688;29104277;29237092;29242379;29557506;29899528;30471091;32938616;33141586;33159882;33981976;34087483;34171305;34932366;35051231;35254053;35260044;35676258;36010968;37938771;38058080;7601448;9346953;9463333;9535912;9915799;9988767",
        "class_list": "glycogene",
        "function": "6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Downregulated HS6ST2 targeted by miR-23b-3p promotes matrix degradation by activating p38 MAPK in chondrocytes and OA cartilage. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of HS6ST2 Inhibits Cervical Cancer Cell Migration and Invasion in Vivo and in Vitro., [RefSeq, PubMed]; HS6ST2 knockdown disrupts epithelial-mesenchymal transition and suggesets that HS6ST2 potentiates Notch signaling in pancreatic cancer cells., [RefSeq, PubMed]; Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; RT-PCR analysis showed that the overall transcriptional activity of the main Heparan Sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1, NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) was decreased by 1.5-2-fold in Grade II-III glioma. Publication Status: Online-Only, [RefSeq, PubMed]; Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis., [RefSeq, PubMed]; We have characterized HS6ST-2 and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulfate to N -sulfoglucosamine residues located at the non-reducing terminal of HS with high affinity., [RefSeq, PubMed]; We identified a novel c.916G>C variant in the HS6ST2 gene. The mutation caused a significantly reduction in HS6ST2 6-O-sulfotransferase activity and was associated with a previously undescribed form of syndromic XLID with severe congenital myopia, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 593,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 1,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9WRT4;B9WRT5;E9PDY5;Q2TB13;Q4VC07;Q6PIC4;Q86SM9;Q8N3T4;Q8NBN4;Q96SJ4",
        "ec_number_list": [
            {
                "id": "2.8.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q96MM7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BXW7-1",
        "uniprot_id": [
            {
                "id": "HDHD5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BXW7",
                "type": "external"
            }
        ],
        "mass": 46321.0,
        "length": 423,
        "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing 5",
        "gene_name": "HDHD5",
        "organism": "Human",
        "refseq_name": "haloacid dehalogenase-like hydrolase domain-containing 5 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_060299",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060299",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HDHD5; CECR5",
        "gene_names_refseq": "CECR5; HDHD5",
        "protein_names_uniprotkb": "Haloacid dehalogenase-like hydrolase domain-containing 5; Cat eye syndrome critical region protein 5",
        "protein_names_refseq": "cat eye syndrome chromosome region, candidate 5; cat eye syndrome critical region protein 5; haloacid dehalogenase-like hydrolase domain-containing 5 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27440)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "11237011;11381032;18477386;20877624;25892735;26992070;27600516;27920218;28510447;28514659;28834231;28904123;29769354;31530632;31844290;31848261;31998317;32157095;32387766;33298915;33592498;33717175;33912179;33968037;33981976;34229054;34509645;34932366;35051231;35083852;35132862;35580925;36241641;36284347;38665916;40596516;40914422",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCK5;Q9BXW8;Q9NWA8;Q9NX41",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0046474 glycerophospholipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9BXW7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H1H1-1",
        "uniprot_id": [
            {
                "id": "GTSFL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H1H1",
                "type": "external"
            }
        ],
        "mass": 16872.0,
        "length": 148,
        "protein_name": "Gametocyte-specific factor 1-like",
        "gene_name": "GTSF1L",
        "organism": "Human",
        "refseq_name": "gametocyte-specific factor 1-like isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001008901",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008901",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTSF1L; C20orf65; FAM112A",
        "gene_names_refseq": "C20orf65; FAM112A; GTSF1L; dJ1028D15.4",
        "protein_names_uniprotkb": "Gametocyte-specific factor 1-like; Protein FAM112A",
        "protein_names_refseq": "family with sequence similarity 112, member A; gametocyte-specific factor 1-like isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:149699)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "18703587;32983136;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JWH5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q9H1H1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRM0-1",
        "uniprot_id": [
            {
                "id": "GTR9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRM0",
                "type": "external"
            }
        ],
        "mass": 58702.0,
        "length": 540,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 9",
        "gene_name": "SLC2A9",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 9 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001001290",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001290",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC2A9; GLUT9",
        "gene_names_refseq": "GLUT9; GLUTX; SLC2A9; UAQTL2; URATv1",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 9; GLUT-9; Glucose transporter type 9; Urate transporter",
        "protein_names_refseq": "GLUT-9; glucose transporter type 9; human glucose transporter-like protein-9; solute carrier family 2 (facilitated glucose transporter), member 9; solute carrier family 2, facilitated glucose transporter member 9 isoform 2; urate transporter; urate voltage-driven efflux transporter 1",
        "tax_id": 9606,
        "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); hyperuricemia (Disease Ontology:DOID:1920); hypouricemia, renal, 2 (MONDO:MONDO:0012793)",
        "pathway": " (hsa:56606);  (R-HSA-189200);  (R-HSA-5619047)",
        "pathway_count": 3,
        "publication_count": 78,
        "publication_id_list": "10821868;10860667;10970791;10987651;11133510;11237011;11245466;11247674;11425315;11583593;11681785;11741323;11780755;11832379;11991658;11994746;12504846;12590146;12885248;1415574;14614622;14739288;14997204;15033637;15607332;15902306;16154905;16550171;17050778;1756912;17635959;17710649;18063724;18327256;18327257;18701466;18842065;19026395;1918382;19189137;19926891;20616166;20934997;21107422;21256783;21810765;21940664;22132964;22212718;22521588;22527535;22647630;24275569;24409316;24628802;24940677;25268603;2656669;26650681;26992070;28083649;28117388;29557506;29769354;29967582;32938616;34185709;35051231;35580925;36010968;36736875;36749388;37176161;37308567;38150892;8457197;9354798;9751501",
        "class_list": "glycogene",
        "function": "GLUT9 as a potential drug target for chronic kidney disease: Drug target validation by a Mendelian randomization study., [RefSeq, PubMed]; GLUT9 is expressed by normal articular chondrocytes., [RefSeq, PubMed]; High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:18701466, PubMed:22647630, PubMed:28083649, PubMed:36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed:18327257, PubMed:18701466, PubMed:18842065). Transports urate at rates 45- to 60-fold faster than glucose (PubMed:18842065). Does not transport galactose (PubMed:28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed:22647630)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Pathogenic Variants of SLC22A12 (URAT1) and SLC2A9 (GLUT9) in Spanish Patients with Renal Hypouricemia: Founder Effect of SLC2A9 Variant c.374C>T; p.(T125M). Publication Status: Online-Only, [RefSeq, PubMed]; Raised CK and acute kidney injury following intense exercise in three patients with a history of exercise intolerance due to homozygous mutations in SLC2A9., [RefSeq, PubMed]; The in-silico evaluation of important GLUT9 residue for uric acid transport based on renal hypouricemia type 2., [RefSeq, PubMed]; This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 780,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VGC4;Q4W5D1;Q8WV30;Q96P00",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0015143 urate transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0046415 urate metabolic process;GO:0015755 fructose transmembrane transport;GO:0008645 hexose transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q9NRM0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010001.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NYZ3-1",
        "uniprot_id": [
            {
                "id": "GTSE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NYZ3",
                "type": "external"
            }
        ],
        "mass": 78505.0,
        "length": 739,
        "protein_name": "G2 and S phase-expressed protein 1",
        "gene_name": "GTSE1",
        "organism": "Human",
        "refseq_name": "G2 and S phase-expressed protein 1 isoform X1",
        "refseq_ac": [
            {
                "id": "XP_047297347",
                "url": "https://www.ncbi.nlm.nih.gov/protein/XP_047297347",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTSE1",
        "gene_names_refseq": "B99; GTSE1",
        "protein_names_uniprotkb": "G2 and S phase-expressed protein 1; GTSE-1; Protein B99 homolog",
        "protein_names_refseq": "G2 and S phase-expressed protein 1 isoform X1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51512);  (R-HSA-69481);  (R-HSA-8852276)",
        "pathway_count": 3,
        "publication_count": 37,
        "publication_id_list": "10974554;12750368;14707141;15302935;15664193;16964243;17322306;17924679;18220336;18452278;18669648;18691976;19007248;19413330;19651622;19664994;19691289;20018861;20058876;20068230;20068231;20577264;23186163;23236459;23301498;23481700;28218747;28510447;28832583;29242379;29393594;29605689;29632046;31154438;31998317;32161166;9844631",
        "class_list": "",
        "function": "May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 52,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QYM3;Q20WK2;Q53GX5;Q5R3I6;Q6DHX4;Q9BRE0;Q9UGZ9;Q9Y557",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0007017 microtubule-based process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9NYZ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UJM8-1",
        "uniprot_id": [
            {
                "id": "HAOX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UJM8",
                "type": "external"
            }
        ],
        "mass": 40924.0,
        "length": 370,
        "protein_name": "2-Hydroxyacid oxidase 1",
        "gene_name": "HAO1",
        "organism": "Human",
        "refseq_name": "2-Hydroxyacid oxidase 1",
        "refseq_ac": [
            {
                "id": "NP_060015",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060015",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAO1; GOX1",
        "gene_names_refseq": "GOX1; GOX; GO; HAO1; HAOX1",
        "protein_names_uniprotkb": "2-Hydroxyacid oxidase 1; 1.1.3.15; 1.2.3.5; GOX; GO; Glycolate oxidase; Glyoxylate oxidase; HAOX1",
        "protein_names_refseq": "(S)-2-hydroxy-acid oxidase; 2-Hydroxyacid oxidase 1; glycolate oxidase 1; glyoxylate oxidase; hydroxyacid oxidase (glycolate oxidase) 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54363);  (R-HSA-389661);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 103,
        "publication_id_list": "10022913;10484776;10524214;10562279;10673331;10777549;10978532;11101887;11546814;11781871;11931631;12456682;12559034;12578380;12717447;12865426;12885776;12899834;13681368;13681370;14170323;15340920;15545321;15802217;15858711;1601857;16616139;16854980;17007944;1703535;17088322;17669354;17726030;18215067;18359941;18712838;19197237;19208625;19352492;19584060;19632994;20018850;20054120;20166139;20178365;20603179;21554508;2158891;21976670;21980954;21998747;22002062;22057399;22371489;22516612;22747494;2363689;23963456;24235149;24275569;24715725;24865970;25016021;25538232;25697095;25747990;25854684;26086376;26138649;26220973;26344566;26858947;27597759;28521612;28611990;28765278;28787099;28832583;29557506;31844290;3416563;34171305;35051231;35494241;35580925;37247262;38214752;500817;6250440;7719337;7790377;8824437;8858165;8991089;9090381;9090382;9090383;9163533;9539740;9653144;9668159;9820813;9837948",
        "class_list": "",
        "function": "Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (PubMed:10978532, PubMed:17669354). Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354, PubMed:18215067). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Glycolate oxidase-1 gene variants influence the risk of hyperoxaluria and renal stone development. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanistic insights into the ROS-mediated inactivation of human aldehyde oxidase., [RefSeq, PubMed]; This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14CQ0;Q9UPZ0;Q9Y3I7",
        "ec_number_list": [
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42",
                "type": "external"
            },
            {
                "id": "1.3.3.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "3.4.24.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56",
                "type": "external"
            },
            {
                "id": "1.4.3.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3",
                "type": "external"
            },
            {
                "id": "2.6.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51",
                "type": "external"
            },
            {
                "id": "2.6.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44",
                "type": "external"
            },
            {
                "id": "2.3.1.176",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "4.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4",
                "type": "external"
            },
            {
                "id": "2.3.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137",
                "type": "external"
            },
            {
                "id": "2.3.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.5.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.4.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.184",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
                "type": "external"
            },
            {
                "id": "1.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38",
                "type": "external"
            },
            {
                "id": "1.3.1.124",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124",
                "type": "external"
            },
            {
                "id": "1.1.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15",
                "type": "external"
            },
            {
                "id": "1.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1",
                "type": "external"
            },
            {
                "id": "1.5.3.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7",
                "type": "external"
            },
            {
                "id": "5.1.99.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4",
                "type": "external"
            },
            {
                "id": "4.1.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63",
                "type": "external"
            },
            {
                "id": "1.2.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0010181 FMN binding;GO:0003973 (S)-2-hydroxy-acid oxidase activity;GO:0047969 glyoxylate oxidase activity",
        "go_cellular_component": "GO:0005782 peroxisomal matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006545 glycine biosynthetic process;GO:0006979 response to oxidative stress;GO:0001561 fatty acid alpha-oxidation;GO:0046296 glycolate catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q9UJM8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UMX6-1",
        "uniprot_id": [
            {
                "id": "GUC1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UMX6",
                "type": "external"
            }
        ],
        "mass": 23420.0,
        "length": 200,
        "protein_name": "Guanylyl cyclase-activating protein 2",
        "gene_name": "GUCA1B",
        "organism": "Human",
        "refseq_name": "guanylyl cyclase-activating protein 2",
        "refseq_ac": [
            {
                "id": "NP_002089",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002089",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCA1B; GCAP2",
        "gene_names_refseq": "GCAP 2; GCAP-2; GCAP-II; GCAP2; GUCA1B; GUCA2; RP48",
        "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 2; GCAP 2; Guanylate cyclase activator 1B",
        "protein_names_refseq": "guanylate cyclase activator 1B (retina); guanylate cyclase-activating protein, photoreceptor 2; guanylyl cyclase-activating protein 2",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 48 (Disease Ontology:DOID:0110382)",
        "pathway": " (hsa:2979);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10037746;10051575;10507726;10564809;10676965;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12499365;12825937;1356371;1379636;1387789;1436039;14702087;15448139;15452722;15946941;16274222;16895762;16908407;17114291;17636946;18803695;19818506;1999465;20430952;20975703;22658984;2540796;2550422;2558719;25616661;26100624;28361875;3006923;3164688;33812995;39894887;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9430683;9459445;9506952;9620085",
        "class_list": "",
        "function": "Dimerization domain of RETGC1 is an essential part of GCAP1 and GCAP2 binding interface., [RefSeq, PubMed]; GCAP1 and GCAP2 bound to different regions on the target guanylate cyclase type 1 with submicromolar affinity (apparent KD-values of 663 +/- 121 nM and 231 +/- 63 nM for Ca(2+)-free GCAP1 and GCAP2, respectively). Publication Status: Online-Only, [RefSeq, PubMed]; Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R., [RefSeq, PubMed]; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1., [RefSeq, PubMed]; The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NU15",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008048 calcium sensitive guanylate cyclase activator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097381 photoreceptor disc membrane;GO:0001917 photoreceptor inner segment;GO:0120199 cone photoreceptor outer segment",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007601 visual perception;GO:0009966 regulation of signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0007589 body fluid secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q9UMX6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0A0MS15-1",
        "uniprot_id": [
            {
                "id": "HV349_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15",
                "type": "external"
            }
        ],
        "mass": 13056.0,
        "length": 119,
        "protein_name": "Immunoglobulin heavy variable 3-49",
        "gene_name": "IGHV3-49",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV3-49",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-49",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 9,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;26992070;28560793;29786170;32561536",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 447,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "A0A0A0MS15-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0B4J1X8-1",
        "uniprot_id": [
            {
                "id": "HV343_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0B4J1X8",
                "type": "external"
            }
        ],
        "mass": 13077.0,
        "length": 118,
        "protein_name": "Immunoglobulin heavy variable 3-43",
        "gene_name": "IGHV3-43",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV3-43",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-43",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 379,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0B4J1X8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0B4J1Y9-1",
        "uniprot_id": [
            {
                "id": "HV372_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0B4J1Y9",
                "type": "external"
            }
        ],
        "mass": 13203.0,
        "length": 119,
        "protein_name": "Immunoglobulin heavy variable 3-72",
        "gene_name": "IGHV3-72",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV3-72",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-72",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;32488085",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 306,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WW89",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0B4J1Y9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH34-1",
        "uniprot_id": [
            {
                "id": "HV428_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0C4DH34",
                "type": "external"
            }
        ],
        "mass": 13124.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 4-28",
        "gene_name": "IGHV4-28",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV4-28",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 4-28",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;32561536",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 307,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0C4DH34-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH38-1",
        "uniprot_id": [
            {
                "id": "HV551_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0C4DH38",
                "type": "external"
            }
        ],
        "mass": 12675.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 5-51",
        "gene_name": "IGHV5-51",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV5-51",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 5-51",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447;36284347",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 494,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0G2JP91",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0C4DH38-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH39-1",
        "uniprot_id": [
            {
                "id": "HV158_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0C4DH39",
                "type": "external"
            }
        ],
        "mass": 13005.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-58",
        "gene_name": "IGHV1-58",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV1-58",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-58",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 312,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0C4DH39-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH42-1",
        "uniprot_id": [
            {
                "id": "HV366_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0C4DH42",
                "type": "external"
            }
        ],
        "mass": 12698.0,
        "length": 116,
        "protein_name": "Immunoglobulin heavy variable 3-66",
        "gene_name": "IGHV3-66",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV3-66",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-66",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11340299;17576170;20176268;22158414;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 327,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0C4DH42-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A2RU49-1",
        "uniprot_id": [
            {
                "id": "HYKK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A2RU49",
                "type": "external"
            }
        ],
        "mass": 41933.0,
        "length": 373,
        "protein_name": "Hydroxylysine kinase",
        "gene_name": "HYKK",
        "organism": "Human",
        "refseq_name": "hydroxylysine kinase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001013641",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013641",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HYKK; AGPHD1",
        "gene_names_refseq": "AGPHD1; HYKK",
        "protein_names_uniprotkb": "Hydroxylysine kinase; 2.7.1.81; 5-hydroxy-L-lysine kinase; Aminoglycoside phosphotransferase domain-containing protein 1",
        "protein_names_refseq": "5-hydroxy-L-lysine kinase; 5-hydroxylysine kinase; aminoglycoside phosphotransferase domain-containing protein 1; hydroxylysine kinase isoform 1",
        "tax_id": 9606,
        "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amino acid metabolic disorder (Disease Ontology:DOID:9252)",
        "pathway": " (hsa:123688);  (R-HSA-71064)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10642506;10775527;11083877;11237011;12126930;15274622;16491085;17242435;18056995;18056996;18775954;19885858;22241472;23481700;24043460;25074529;25854352;25931162;26992070;27072204;28832583;28834231;28904123;30429286;30833945;32157095;32488085;32938616;33141586;33968037;34171305;35051231;36215666;36241641;6434529",
        "class_list": "",
        "function": "CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers., [RefSeq, PubMed]; Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The association between AGPHD1 single nucleotide polymorphism rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that AGPHD1 single nucleotide polymorphism rs8034191 is a risk factor for lung cancer., [RefSeq, PubMed]; The variant rs8034191 in the AGPHD1 gene may not modify the genetic risk of lung cancer in Asian populations., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZMA5;F8W6X5;Q6ZTN0",
        "ec_number_list": [
            {
                "id": "2.7.1.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.81",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047992 hydroxylysine kinase activity;GO:0019202 amino acid kinase activity",
        "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006554 lysine catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "A2RU49-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B1ANH7-1",
        "uniprot_id": [
            {
                "id": "IBADT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B1ANH7",
                "type": "external"
            }
        ],
        "mass": 12198.0,
        "length": 110,
        "protein_name": "Putative uncharacterized protein IBA57-DT",
        "gene_name": "IBA57-DT",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IBA57-DT; C1orf148; IBA57-AS1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein IBA57-DT; IBA57 antisense RNA 1; IBA57 antisense gene protein 1; IBA57 divergent transcripte",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "B1ANH7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q01629-1",
        "uniprot_id": [
            {
                "id": "IFM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q01629",
                "type": "external"
            }
        ],
        "mass": 14632.0,
        "length": 132,
        "protein_name": "Interferon-induced transmembrane protein 2",
        "gene_name": "IFITM2",
        "organism": "Human",
        "refseq_name": "interferon-induced transmembrane protein 2",
        "refseq_ac": [
            {
                "id": "NP_006426",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006426",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFITM2",
        "gene_names_refseq": "1-8D; DSPA2c; IFITM2",
        "protein_names_uniprotkb": "Interferon-induced transmembrane protein 2; DSPA2c; Dispanin subfamily A member 2c; Interferon-inducible protein 1-8D",
        "protein_names_refseq": "dispanin subfamily A member 2c; interferon-induced transmembrane protein 2; interferon-inducible protein 1-8D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10581);  (R-HSA-909733)",
        "pathway_count": 2,
        "publication_count": 129,
        "publication_id_list": "10395669;10542297;10982844;11092454;11237011;11337497;11377645;11404376;11585831;12029096;12766484;12842042;14769151;15047845;15312780;15449939;15778442;16009940;16171819;16987978;17251292;1730654;17351669;17969444;18035202;18575461;1906403;19544527;20064371;20068231;20130243;20363976;20534863;20643137;20943977;21166591;21177806;21253575;2211721;22363774;22479637;22898188;23061660;23121362;23481700;24417533;25371710;25502872;26354436;27543614;27600516;28218747;28228285;28467828;28489076;28832583;29242379;29314611;29331515;29493099;29508533;29557506;29632711;29786170;29789417;30192525;30315122;30485383;30524438;31154438;31611695;31848261;32032529;32113509;32157095;32350084;32502341;32511913;32574262;32661006;32758689;32862111;32938616;32983136;33117408;33123756;33189161;33193462;33239446;33270927;33298915;33396578;33563656;33592498;33633747;33912179;33936100;34087483;34171305;34357683;34433824;34933450;35051231;35318648;35543509;35580925;36284347;37112847;39321709;6162102;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8605876;8621447;8702790;9096384;9121453;9242679;9334213;9366419;9660177;9847332;9861020",
        "class_list": "",
        "function": "IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927, PubMed:33563656). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner., [RefSeq, PubMed]; Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]., [RefSeq]; SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells., [RefSeq, PubMed]; Single Nucleotide Polymorphisms in 1-8D is associated with neoplasms., [RefSeq, PubMed]; Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FH82;Q96DA8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0032991 protein-containing complex;GO:0016020 membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "Q01629-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P41091-1",
        "uniprot_id": [
            {
                "id": "IF2G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P41091",
                "type": "external"
            }
        ],
        "mass": 51109.0,
        "length": 472,
        "protein_name": "Eukaryotic translation initiation factor 2 subunit 3",
        "gene_name": "EIF2S3",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 2 subunit 3",
        "refseq_ac": [
            {
                "id": "NP_001406",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EIF2S3; EIF2G",
        "gene_names_refseq": "EIF2G; EIF2S3; EIF2gamma; EIF2; MEHMO; MRXSBRK; eIF-2gA; eIF2gX",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma X; eIF2-gamma X; eIF2gX",
        "protein_names_refseq": "eIF-2-gamma X; eIF-2gX; eIF2-gamma X; eukaryotic translation initiation factor 2 subunit 3; eukaryotic translation initiation factor 2 subunit gamma X; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly and obesity syndrome",
        "tax_id": 9606,
        "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); leukodystrophy (Disease Ontology:DOID:10579); Alzheimer's disease (Disease Ontology:DOID:10652); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypopituitarism (Disease Ontology:DOID:9406)",
        "pathway": " (hsa:1968);  (R-HSA-156827);  (R-HSA-381042);  (R-HSA-382556);  (R-HSA-72649);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-72731);  (R-HSA-9633012);  (R-HSA-9648895);  (R-HSA-9833482);  (R-HSA-9840373)",
        "pathway_count": 13,
        "publication_count": 370,
        "publication_id_list": "10026192;10082513;10348343;10364207;10400669;10484077;10620360;10626894;10648614;10659855;10665657;10748049;10848580;10866685;1095581;10982836;11018020;11018027;1104615;11096080;11134010;11152499;11156368;11163539;11237011;11238103;11238927;11241327;11278865;11313968;11337501;11350938;11438540;11500375;11504826;11562789;11677247;11691921;11781817;11812794;11907036;11909525;11939789;11985496;12231563;12370288;12379217;12379510;12397061;12403779;12588972;12604685;12665801;12882984;1352877;1356264;1359686;1373135;1377674;1400365;14567916;14585331;14630918;14661924;15104674;15175422;15229216;15299030;15314157;15385533;15472518;15737233;15752359;15775988;15781252;15863492;15899824;15907845;16026328;16115862;16179258;16179259;16288713;16373505;16408927;16431927;16600570;16717090;16816140;16901789;1695551;16982605;16989641;17079286;17140605;17196820;17267404;17523162;17726049;17855752;17894550;17956313;17977821;18055463;18096616;18282684;18285520;18434309;1856230;18664456;18835251;18957415;19002207;19054851;19229320;19416861;19447222;19570978;1968359;19710021;19733181;19804757;19838063;19862647;1998343;20068231;20361218;20395957;20423929;20519500;20583968;20621639;20685959;21072047;21123651;21209280;21294215;21518807;21636578;21937648;21978664;21994559;22178883;22214662;22322005;2247437;22986343;23063411;23063529;23084476;23229543;23269699;23301498;23481700;23732991;23876217;24019521;24347309;24366607;24623135;24659800;24685677;24714562;24715725;24753571;2475911;2491852;25133187;25433032;25576301;25645385;25653431;2570070;25848059;25931127;26154972;26208431;26432638;26446704;26488609;26716879;26728094;26817845;26853435;26923599;26992070;27208315;27269119;27333055;27423063;27526673;27600516;27846572;27862975;27920218;27974558;28055140;28069888;28132103;28167698;28228285;28281686;28649982;28765891;28814160;28832583;28834231;28904123;2898143;29170442;29175459;29231267;29242379;29348664;29351928;29393594;29394925;29395325;29401259;29413899;29437277;29440070;29493099;29501855;29508533;29557506;29632046;29786170;30174290;30315122;30429286;30517694;30524438;30551605;30770398;30779550;30804176;30833945;30878599;31031002;31048491;31048492;31154438;31217245;31530632;31836389;31844290;31848261;31998317;32093270;32119511;32132706;32132707;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32716602;32799315;32801355;32870666;32897882;32938616;32981041;32983136;33141586;33214551;33298915;33392160;3356695;33592498;33633747;33691108;33717175;33808629;33911136;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34174402;34185709;34211107;34232382;34405274;34509645;34561969;3457471;3472246;34725712;34932366;34974812;34999262;35031321;35051231;35132862;35138101;35154160;35163244;35251023;35318648;35388015;35561310;35580925;35685460;35947956;36010968;36215666;36241641;36284347;36712380;37127961;37217939;37327776;37507029;37550454;37938771;38665916;40596516;40914422;429297;592398;592399;641056;6853548;7000367;7491766;7515177;7523390;7529176;7545299;7553863;7553864;7565688;7693978;7737357;7865904;7903669;8106381;8336711;8576172;8576179;8661426;8810342;8910500;8943342;9034343;9045610;9079663;9153226;9211906;9442054;9521856;9528799;9652413;9687506;9732867;9736774;9737981;9816258;9819388;9831708;9857202;9920933",
        "class_list": "",
        "function": "Binding of human Cdc123 to eIF2gamma., [RefSeq, PubMed]; Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia., [RefSeq, PubMed]; MRNA analysis revealed a novel pathogenic EIF2S3 variant causing MEHMO syndrome., [RefSeq, PubMed]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)., [UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024RBY4;A8K2Y2;B2R5N2;B5BTZ4;Q53HK3",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0045296 cadherin binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005850 eukaryotic translation initiation factor 2 complex",
        "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001731 formation of translation preinitiation complex;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 37.4,
        "record_id": "P41091-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "K9M1U5-1",
        "uniprot_id": [
            {
                "id": "IFNL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/K9M1U5",
                "type": "external"
            }
        ],
        "mass": 19675.0,
        "length": 179,
        "protein_name": "Interferon lambda-4",
        "gene_name": "IFNL4",
        "organism": "Human",
        "refseq_name": "interferon lambda-4 precursor",
        "refseq_ac": [
            {
                "id": "NP_001263183",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263183",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFNL4",
        "gene_names_refseq": "IFNAN; IFNL4",
        "protein_names_uniprotkb": "Interferon lambda-4; IFN-lambda-4",
        "protein_names_refseq": "IFN-lambda-4; interferon lambda-4 precursor; interferon, lambda 4",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); autosomal hemophilia A (Disease Ontology:DOID:0111823); hepatitis C (Disease Ontology:DOID:1883); cryoglobulinemia (Disease Ontology:DOID:2917); liver cirrhosis (Disease Ontology:DOID:5082); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)",
        "pathway": " (hsa:101180976)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "23291588;23956438;24205831;25329461;36880961;37098852;37366802;38003018",
        "class_list": "",
        "function": "A Novel Inactive Isoform with a Restored Reading Frame Is Expressed from the Human Interferon Lambda 4 TT Allele at rs368234815., [RefSeq, PubMed]; A new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus., [RefSeq, PubMed]; Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes., [UniProtKB, PubMed]; IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa., [RefSeq, PubMed]; IFNL4 improves prediction of response to interferon-based hepatitis C therapies, if SNP rs8099917 is used., [RefSeq, PubMed]; IFNL4-DeltaG is strongly associated with impaired spontaneous hepatitis C virus clearance., [RefSeq, PubMed]; Natural selection history of IFNL4-inactivating allele has thus shaped present-day heterogeneity across populations not only in genetic variation, but also in relevant phenotypes and susceptibility to hepatitis C. Erratum:[PLoS Genet. 2014 Nov;10(11):e1004882] Publication Status: Online-Only, [RefSeq, PubMed]; Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV., [RefSeq, PubMed]; This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017]., [RefSeq]; Variants of IFNL4 Gene in Amazonian and Northern Brazilian Populations. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "K9M1A5;K9M269;K9M2P7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0098586 cellular response to virus;GO:0050778 positive regulation of immune response;GO:0007260 tyrosine phosphorylation of STAT protein",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "K9M1U5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00219-1",
        "uniprot_id": [
            {
                "id": "HYAS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00219",
                "type": "external"
            }
        ],
        "mass": 62998.0,
        "length": 553,
        "protein_name": "Hyaluronan synthase 3",
        "gene_name": "HAS3",
        "organism": "Human",
        "refseq_name": "hyaluronan synthase 3 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001186209",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186209",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAS3",
        "gene_names_refseq": "HAS3",
        "protein_names_uniprotkb": "Hyaluronan synthase 3; 2.4.1.212; HA synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3",
        "protein_names_refseq": "HA synthase 3; hyaluronan synthase 3 isoform a; hyaluronate synthase 3; hyaluronic acid synthase 3",
        "tax_id": 9606,
        "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:3038);  (R-HSA-2142845)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10037799;11237011;1426053;15208308;1703543;17145755;17540771;18434317;23303191;24847057;25418920;25576301;25795779;26883802;30394292;30833945;32488085;33968037;34171305;35051231;35269567;35998871;36497040;38402581;38844132;8798477;8798544;8890751;9083017;9601098",
        "class_list": "glycogene;glycosyltransferase",
        "function": "4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression. Publication Status: Online-Only, [RefSeq, PubMed]; A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis., [UniProtKB, PubMed, PubMed, PubMed]; Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3., [RefSeq, PubMed]; Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response., [RefSeq, PubMed]; Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis., [RefSeq, PubMed]; The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 501,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5T5;Q8WTZ0;Q9NYP0",
        "ec_number_list": [
            {
                "id": "2.4.1.212",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0005975 carbohydrate metabolic process;GO:0045893 positive regulation of DNA-templated transcription;GO:1900106 positive regulation of hyaluranon cable assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "O00219-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95998-2",
        "uniprot_id": [
            {
                "id": "I18BP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95998",
                "type": "external"
            }
        ],
        "mass": 21099.0,
        "length": 194,
        "protein_name": "Interleukin-18-binding protein",
        "gene_name": "IL18BP",
        "organism": "Human",
        "refseq_name": "interleukin-18-binding protein isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001034748",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034748",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL18BP",
        "gene_names_refseq": "FVH; IL18BPa; IL18BP",
        "protein_names_uniprotkb": "Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa",
        "protein_names_refseq": "MC51L-53L-54L homolog gene product; interleukin-18-binding protein isoform a precursor; tadekinig-alfa",
        "tax_id": 9606,
        "disease": "alcoholic liver cirrhosis (Disease Ontology:DOID:14018); cystic fibrosis (Disease Ontology:DOID:1485); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); hepatitis, fulminant viral, susceptibility to (MONDO:MONDO:0032809)",
        "pathway": " (hsa:10068);  (R-HSA-9008059);  (R-HSA-9012546)",
        "pathway_count": 3,
        "publication_count": 38,
        "publication_id_list": "10.1038/emboj.2013.79;10023777;10094485;10329540;10655506;11145836;11739524;11839743;11907126;12096920;12381835;12809600;15340161;15527767;18390730;20935647;22171320;23584533;24481253;25729923;27060871;28092676;29557506;30237853;30459171;31154438;31213488;31848261;32157095;35251023;35398099;35580925;35705877;36742296;37074911;37083154;9325300;9792649",
        "class_list": "",
        "function": "Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study., [RefSeq, PubMed]; IL-18BP messenger transcript and protein are significantly increased in surgically resected specimens from active Crohn's disease compared with control patients, correlating with an up-regulation of IL-18., [RefSeq, PubMed]; Interleukin-18 and IL-18BP in inflammatory dermatological diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis., [RefSeq, PubMed]; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response., [UniProtKB, PubMed, PubMed, PubMed]; Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity., [RefSeq, PubMed]; The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]., [RefSeq]; Trancriptional activation and release of IL-18 binding protein in response to IFN-gamma, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 7,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUZ0;B7WPK4;O95993;O96027;Q9NZA9;Q9UBR7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0042007 interleukin-18 binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0042088 T-helper 1 type immune response;GO:0070301 cellular response to hydrogen peroxide;GO:0071356 cellular response to tumor necrosis factor;GO:0002826 negative regulation of T-helper 1 type immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "O95998-2",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01566-1",
        "uniprot_id": [
            {
                "id": "IFN10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01566",
                "type": "external"
            }
        ],
        "mass": 21835.0,
        "length": 189,
        "protein_name": "Interferon alpha-10",
        "gene_name": "IFNA10",
        "organism": "Human",
        "refseq_name": "interferon alpha-10 precursor",
        "refseq_ac": [
            {
                "id": "NP_002162",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002162",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFNA10",
        "gene_names_refseq": "IFN-alphaC; IFNA10",
        "protein_names_uniprotkb": "Interferon alpha-10; IFN-alpha-10; Interferon alpha-6L; Interferon alpha-C; LeIF C",
        "protein_names_refseq": "IFN-alpha-10; interferon alpha-10 precursor; interferon alpha-6L; interferon alpha-C; leIF C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3446);  (R-HSA-909733);  (R-HSA-912694);  (R-HSA-933541);  (R-HSA-9705671);  (R-HSA-983231);  (R-HSA-9833109)",
        "pathway_count": 7,
        "publication_count": 186,
        "publication_id_list": "10022928;10395669;10421793;10542297;10581243;10982844;11042108;11062261;11073981;11092454;11242053;11337497;11377645;11404376;11585831;11694501;11744692;11751636;11895428;11950885;12019269;12029096;12032298;12133833;12134158;12427746;12604599;12692549;12759408;12766484;12842042;14769151;15020713;15047845;15208624;15247287;15312780;15361868;15449939;15710388;15778442;16009940;16054028;16125763;16127453;16153868;16171819;1630448;16710296;16914100;16987978;17027967;17196961;17251292;1730654;17327220;17351669;17392790;17969444;18035202;18508557;18575461;19193793;19293402;19479062;19668221;20043992;20130243;20363976;20530532;20627800;20643137;20722470;21632562;218813;2211721;22383950;22619329;22941947;23061660;23121362;23453971;24030809;24417533;24722368;2526839;25371710;26000985;26845023;30485383;30558248;31850239;32032529;32113509;32353859;32428392;32511913;32574262;32589897;32661006;32726803;32728199;32758689;32862111;32953130;32979938;33024073;33060197;33097660;33110251;33117408;33189161;33193462;33349665;33360543;33372174;33372854;33396578;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;3409321;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35102342;35643212;37051252;6162102;6163083;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8605876;8621447;8662638;8702790;8816476;8943354;9065479;9096384;9121453;9230307;9242679;9326583;9331217;9334213;9422515;9425112;9660177;9660935;9822609;9847332;9861020;9927674",
        "class_list": "",
        "function": "Heterozygous IFNA10 variants is a cause of impaired function and CD-susceptibility genes in Chinese individuals from multiple center based study. Publication Status: Online-Only, [RefSeq, PubMed]; IFN-alpha8 and -alpha10 most potently enhanced expression of IFN-gamma, IL-2, and IL-4., [RefSeq, PubMed]; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]; This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013]., [RefSeq]; We did not reproduce the associations previously noted with the TNF, IFNA10, IFNA17, and IFNG genes with pulmonary sarcoidosis. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VV13",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 18.7,
        "record_id": "P01566-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01571-1",
        "uniprot_id": [
            {
                "id": "IFN17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01571",
                "type": "external"
            }
        ],
        "mass": 21728.0,
        "length": 189,
        "protein_name": "Interferon alpha-17",
        "gene_name": "IFNA17",
        "organism": "Human",
        "refseq_name": "interferon alpha-17 precursor",
        "refseq_ac": [
            {
                "id": "NP_067091",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067091",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFNA17",
        "gene_names_refseq": "IFN-alphaI; IFNA17; IFNA; INFA; LEIF2C1",
        "protein_names_uniprotkb": "Interferon alpha-17; IFN-alpha-17; Interferon alpha-88; Interferon alpha-I'; Interferon alpha-T; LeIF I",
        "protein_names_refseq": "IFN-alpha-17; interferon alpha-17 precursor; interferon alpha-88; interferon alpha-I'; interferon alpha-T; interferon alpha-WA; leIF I",
        "tax_id": 9606,
        "disease": "sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287)",
        "pathway": " (hsa:3451);  (R-HSA-909733);  (R-HSA-912694);  (R-HSA-933541);  (R-HSA-9705671);  (R-HSA-983231);  (R-HSA-9833109)",
        "pathway_count": 7,
        "publication_count": 196,
        "publication_id_list": "10022928;10395669;10421793;10542297;10581243;10982844;11042108;11062261;11073981;11092454;11242053;11337497;11377645;11404376;11585831;11694501;11744692;11751636;11895428;11950885;12019269;12029096;12032298;12133833;12134158;12427746;12490311;12604599;12692549;12759408;12766484;12842042;14769151;15020713;15047845;15208624;15247287;15312780;15361868;15449939;15710388;15778442;16009940;16054028;16125763;16127453;16153868;16171819;1630448;1634550;16710296;16914100;1698366;16987978;17027967;1709418;17196961;17251292;1730654;17327220;17351669;17392790;17969444;18035202;18508557;18575461;19193793;19293402;19479062;19668221;20043992;20130243;20363976;20530532;20588308;20627800;20643137;20722470;21632562;218813;2211721;22383950;22619329;22941947;23061660;23121362;23453971;24417533;24722368;25371710;2562206;26694082;26845023;30485383;30558248;31850239;32032529;32113509;32353859;32428392;32502341;32511913;32574262;32589897;32661006;32726803;32728199;32758689;32862111;32953130;32979938;33024073;33060197;33097660;33110251;33117408;33189161;33193462;33349665;33360543;33372174;33372854;33396578;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;3409321;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35102342;35643212;37020259;37051252;3767336;3891272;4008999;6162102;6165082;6548414;688397;7510216;7526154;7537377;7540766;8197134;8232552;8605876;8621447;8662638;8702790;8816476;8943354;9065479;9096384;9121453;9230307;9242679;9326583;9331217;9334213;9422515;9425112;9660177;9660935;9712362;9822609;9847332;9861020;9927674",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB, PubMed]; Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Erratum:[Genome Med. 2024 Jan 6;16(1):6. doi: 10.1186/s13073-023-01278-0. PMID: 38184654] Publication Status: Online-Only, [RefSeq, PubMed]; Results show that IFNA1 rs1332190 and IFNA17 rs9298814 SNPs may play an important role in Crimean-Congo hemorrhagic fever susceptibility, [RefSeq, PubMed]; We did not reproduce the associations previously noted with the TNF, IFNA10, IFNA17, and IFNG genes with pulmonary sarcoidosis. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14639;Q4KMT4;Q5VZ53;Q7M4Q4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 19.7,
        "record_id": "P01571-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01574-1",
        "uniprot_id": [
            {
                "id": "IFNB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01574",
                "type": "external"
            }
        ],
        "mass": 22294.0,
        "length": 187,
        "protein_name": "Interferon beta",
        "gene_name": "IFNB1",
        "organism": "Human",
        "refseq_name": "interferon beta precursor",
        "refseq_ac": [
            {
                "id": "NP_002167",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002167",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFNB1; IFB; IFNB",
        "gene_names_refseq": "IFB; IFF; IFN-beta; IFNB1; IFNB",
        "protein_names_uniprotkb": "Interferon beta; Fibroblast interferon; IFN-beta",
        "protein_names_refseq": "fibroblast interferon; interferon beta precursor; interferon, beta 1, fibroblast; interferon-beta",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); cerebral infarction (Disease Ontology:DOID:3526); proteinuria (Disease Ontology:DOID:576); retinoblastoma (Disease Ontology:DOID:768)",
        "pathway": " (hsa:3456);  (R-HSA-2559580);  (R-HSA-909733);  (R-HSA-912694);  (R-HSA-918233);  (R-HSA-933541);  (R-HSA-9705671);  (R-HSA-983231);  (R-HSA-9833109)",
        "pathway_count": 9,
        "publication_count": 283,
        "publication_id_list": "10022928;10049744;10082512;10347217;10395669;10421793;10542297;10556041;10581243;10722742;10772813;10871633;10982844;11042108;11062261;11073981;11092454;11242053;11244049;11337497;11377645;11404376;11564866;11585831;11694501;11744692;11751636;11895428;11950885;12019269;12029096;12032298;12133833;12134156;12134158;12189133;12193592;12421820;12427746;12435631;12604599;12692549;12759408;12766484;12808055;12842042;13130464;14507994;14532106;14703513;14735143;14769151;15020713;15047845;15208624;15247287;15287722;15312780;15361868;15449939;15563468;15710388;15778442;15866172;16009940;16054028;16125763;16127453;16153868;16171819;16186825;16281057;1630448;16306936;16337592;16436515;16593086;16710296;16826196;16846591;16858409;16914100;16959974;16987978;17027967;17190786;17196961;17210787;17251292;17254968;17255097;1730654;17327220;17332741;17344414;17351669;17392790;17395714;17526488;17765224;17825402;17875933;17969444;18035202;18365017;18508557;18575461;18793328;19054851;19193793;19293402;19451217;19451218;19462008;19479062;19528227;19668221;20043992;20130243;20363976;20530532;20627800;20643137;21632562;218813;21986495;22020331;2211721;22325352;22336108;22383950;22619329;22683641;22941947;23061660;23121362;23449998;23453971;2414376;24417533;24722368;25371710;26845023;30485383;30558248;31850239;32032529;32113509;32353859;32428392;32511913;32574262;32589897;32661006;32726803;32728199;32758689;32862111;32953130;32979938;33024073;33060197;33097660;33110251;33117408;33189161;33193462;33349665;33360543;33372174;33372854;33396578;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;3409321;34110168;34166398;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35102342;35643212;3667593;37051252;38067135;38203523;6157094;6157601;6159580;6159584;6159597;6162102;6162107;6164984;6171735;6548414;688397;7510216;7526154;7535770;7537377;7540766;7588633;7665574;7813427;7816143;7859739;8001816;8027027;8078588;8197134;8232552;8259215;8319905;8469319;8605876;8621447;8622669;8622688;8626550;8662638;8702790;8741839;8774846;8798579;8816476;8846784;8943354;8969169;8974401;9030721;9065479;9096384;9121453;9162092;9195981;9230307;9242679;9326583;9331217;9334213;9342320;9345408;9422515;9463386;9529249;9541017;9564042;9628874;9660177;9660935;9768359;9822609;9824166;9847332;9861020;9927674",
        "class_list": "",
        "function": "C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-beta Expression through Regulating IRF-3. Publication Status: Online-Only, [RefSeq, PubMed]; IFN-gamma and its downstream antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against M.leprae in vitro; IFN-beta and its downstream genes,including IL-10, were induced in monocytes by M.leprae and preferentially expressed in disseminated and progressive lepromatous lesions, [RefSeq, PubMed]; This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]., [RefSeq]; Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:10049744, PubMed:10556041, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VWC9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0008811 chloramphenicol O-acetyltransferase activity;GO:0005126 cytokine receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0002312 B cell activation involved in immune response;GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 28.8,
        "record_id": "P01574-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01817-1",
        "uniprot_id": [
            {
                "id": "HV205_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01817",
                "type": "external"
            }
        ],
        "mass": 13231.0,
        "length": 119,
        "protein_name": "Immunoglobulin heavy variable 2-5",
        "gene_name": "IGHV2-5",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV2-5",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 2-5; Ig heavy chain V-II region HE; Ig heavy chain V-II region MCE",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
        "pathway_count": 19,
        "publication_count": 533,
        "publication_id_list": "10026222;10051622;10068651;10072481;1008494;10087012;10219243;10224668;10381560;10395673;10432293;10496324;10498607;10499918;10523831;10531307;10556826;10559936;10579907;10606205;10648173;1067618;10702308;10706702;10724160;10746781;10764623;10770799;10781580;1081164;10838074;10860980;10861086;10878810;10880360;10882101;10917520;10925294;10983984;10995437;11007481;11015619;11030334;11042164;11071869;11090634;11157975;11196644;11207550;11226282;11231582;11256994;11265639;11276226;11278486;11306453;11325957;11329366;11340081;11340169;11340299;11368773;11395409;11425868;11449366;11460167;11489943;11513152;11553796;11556966;11564780;11606584;11694537;11713268;11747816;11749377;11772397;11779189;11804587;11807247;11812992;11829459;11854399;11857637;11858820;11861603;11877257;11901194;11909947;11939578;11955593;11955595;11955599;11994425;12055245;12055636;12070135;12105426;12117970;12181444;12189515;12208882;12213210;12213321;12217391;12235133;12396008;12417718;12453414;12456653;12469115;12473184;12483297;1249422;1252417;12573241;12588680;12660731;12670394;12670955;12743368;12782713;12869549;12975316;1314888;13342742;13472068;1372004;1372019;1374290;1375264;1376928;1386357;14280442;14514672;14529530;14615387;14630197;14676198;14719373;14970179;15000751;15010370;15034010;15040784;15125833;15136729;15155468;15161916;15187135;15187158;15199963;15294978;15304001;15327770;15448162;15452139;1550550;15509800;15528364;15534202;15536084;15541655;15542058;15548136;15580655;15607800;15657136;15681301;15686303;15697213;15721307;15778510;15781451;15800062;15809313;15851719;15864273;15879134;1591491;15947085;1599430;16014749;16046400;16079145;16091383;16115318;16129954;16186825;16189277;16192651;16252004;16258728;16262445;16297198;16339513;16356853;16356856;16380601;16408005;16456001;1646599;16497229;16522641;16546099;16551255;16585556;16641196;16678913;16691243;16702231;16737824;16737840;16754721;16778136;16783819;16831874;16849466;16880808;16893496;16904340;16906149;16921024;16928187;16938345;16978534;16999828;17008602;1702903;17045824;17047224;1705565;17057721;17064312;17099249;17102136;17116209;17135271;17158449;17167768;17172599;17182573;17188549;17202194;17224452;17237375;17308335;17322099;17337780;17379836;17428801;17442946;17452328;17452516;17486119;17496917;17498065;17502104;17505016;17505110;17525755;17540168;17563375;17576170;17580308;17590538;17600130;17615384;17625065;17662961;17845074;17948050;17993265;18006696;18025150;18031695;18037897;18052078;18055229;18070890;18187424;18209062;18234675;18296442;18326500;18391171;18420269;18556779;18593354;18596693;18772140;18818202;18843204;18995841;19124833;19149696;19206206;19249086;19279206;19324878;19359216;19372136;19574218;19592130;19592646;19650691;19741094;19909365;19955216;2011584;20176268;20192804;20223979;20300203;20430887;20685844;20730098;20920479;21037092;21193412;21241660;21408196;21419341;21469132;21653832;21659548;21788512;21800138;21822214;21841309;21877119;21966355;22158414;22180443;22210847;22396535;22401777;22492620;22552008;22798961;22802338;22814904;22922649;2303036;2304550;23487775;23641311;23675550;23695528;23836650;23929856;23945545;24043627;2420889;24272870;24305946;24584101;24600447;2465906;2466593;2474607;24764293;2481448;25200415;2529342;2538457;25703557;25716998;25801024;26002965;26284469;26300885;2806549;2833500;2833705;28425720;293688;293746;2956252;2971659;29945920;301546;30201761;31048504;32350084;3500860;3848661;3891754;4074707;4098172;4327491;4589993;468991;496916;5135507;5264153;6019133;6214588;6219696;6222381;6230668;6238120;6334079;6335036;6454142;6480598;6607952;670886;6780622;6849882;6906228;702059;70787;7263686;7287740;7378053;7391570;7391573;7509040;7512959;7516890;7517665;7518558;7521687;7521878;7522622;7524079;7526393;7528218;7528327;7530449;7531291;7538118;7542404;7542572;7561031;7592958;760802;761607;7618087;7687428;7687539;7688784;7690834;7691807;7691959;7706301;7718892;7848918;7855889;7927516;7997270;803528;8071371;814163;8163536;8163559;8166770;8178173;8226994;8228618;8306975;8314844;8327478;8340414;8345200;8424694;8475064;8493579;8495193;8538770;8541526;8611682;8629002;8630736;8631904;8657103;8663278;8673706;8702662;8786315;8799126;8809042;8855948;8862523;8910399;8947047;8986718;8995416;8995445;9000504;9038722;9042338;9050880;9052782;9099726;9162098;9169774;9199344;9235916;9242610;9285412;9295288;9295361;9314552;9314561;9326643;9341187;9382878;9382888;9477973;9480991;9547345;9600938;9601638;9639556;9693095;9697839;9700512;9705280;9705962;971416;9730896;9763524;978134;9799231;9843499;9857068;9883880;9885284;9890995;9973503;9989831",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 507,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MS10;P01818",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 53.4,
        "record_id": "P01817-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01824-1",
        "uniprot_id": [
            {
                "id": "HV439_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01824",
                "type": "external"
            }
        ],
        "mass": 13917.0,
        "length": 125,
        "protein_name": "Immunoglobulin heavy variable 4-39",
        "gene_name": "IGHV4-39",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV4-39",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 4-39; Ig heavy chain V-II region WAH",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
        "pathway_count": 19,
        "publication_count": 541,
        "publication_id_list": "10026222;10051622;10068651;10072481;1008494;10087012;10219243;10224668;10381560;10395673;10432293;10496324;10498607;10499918;10523831;10531307;10556826;10559936;10579907;10606205;10648173;1067618;10702308;10706702;10724160;10746781;10764623;10770799;10781580;1081164;10838074;10860980;10861086;10878810;10880360;10882101;10917520;10925294;10983984;10995437;11007481;11015619;11030334;11042164;11071869;11090634;11157975;11196644;11207550;11226282;11231582;11256994;11265639;11276226;11278486;11306453;11325957;11329366;11340081;11340169;11340299;11368773;11395409;11425868;11449366;11460167;11489943;11513152;11553796;11556966;11564780;11606584;11694537;11713268;11747816;11749377;11772397;11779189;11804587;11807247;11812992;11829459;11854399;11857637;11858820;11861603;11877257;11901194;11909947;11939578;11955593;11955595;11955599;11994425;12055245;12055636;12070135;12105426;12117970;12181444;12189515;12208882;12213210;12213321;12217391;12235133;12396008;12417718;12453414;12456653;12469115;12473184;12483297;1249422;1252417;12573241;12588680;12660731;12670394;12670955;12743368;12782713;12869549;12975316;1314888;13342742;13472068;1372004;1372019;1374290;1375264;1376928;1386357;14280442;14514672;14529530;14615387;14630197;14676198;14719373;14970179;15000751;15010370;15034010;15040784;15125833;15136729;15155468;15161916;15187135;15187158;15199963;15294978;15304001;15327770;15448162;15452139;1550550;15509800;15528364;15534202;15536084;15541655;15542058;15548136;15580655;15607800;15657136;15681301;15686303;15697213;15721307;15778510;15781451;15800062;15809313;15851719;15864273;15879134;1591491;15947085;1599430;16014749;16046400;16079145;16091383;16115318;16129954;16157351;16186825;16189277;16192651;16252004;16258728;16262445;16297198;16339513;16356853;16356856;16380601;16408005;16456001;1646599;16497229;16522641;16546099;16551255;16585556;16641196;16678913;16691243;16702231;16737824;16737840;16754721;16778136;16783819;16831874;16849466;16880808;16893496;16904340;16906149;16921024;16928187;16938345;16978534;16999828;17008602;1702903;17045824;17047224;1705565;17057721;17064312;17099249;17102136;17116209;17135271;17158449;17167768;17172599;17182573;17188549;17202194;17224452;17237375;17308335;17322099;17337780;17379836;17428801;17442946;17452328;17452516;17486119;17496917;17498065;17502104;17505016;17505110;17525755;17540168;17563375;17576170;17580308;17590538;17600130;17615384;17625065;17662961;17845074;17948050;17993265;18006696;18025150;18031695;18037897;18052078;18055229;18070890;18187424;18209062;18234675;18296442;18326500;18391171;18420269;18556779;18593354;18596693;18772140;18818202;18843204;18995841;19124833;19149696;19206206;19249086;19279206;19324878;19359216;19372136;19574218;19592130;19592646;19650691;19741094;19909365;19955216;2011584;20176268;20192804;20223979;20300203;20430887;20685844;20730098;20920479;21037092;21193412;21241660;21408196;21419341;21469132;21653832;21659548;21788512;21800138;21822214;21841309;21877119;21966355;22158414;22180443;22210847;22396535;22401777;22492620;22552008;22798961;22802338;22814904;22922649;2303036;2304550;23487775;23641311;23675550;23695528;23836650;23929856;23945545;24043627;2420889;24272870;24305946;24584101;24600447;2465906;2466593;2474607;24764293;2481448;25200415;2529342;2538457;25703557;25716998;25801024;26002965;26284469;26300885;26992070;27999743;2806549;2833500;2833705;28425720;293688;293746;2956252;2971659;29769354;29786170;29945920;301546;30201761;31048504;32983136;3500860;35051231;35580925;36284347;3848661;3891754;4074707;4098172;4327491;4589993;468991;496916;5135507;6019133;6214588;6219696;6222381;6230668;6238120;6334079;6335036;6454142;6480598;6607952;6619128;670886;6806818;6849882;6906228;702059;70787;7263686;7287740;7378053;7391570;7391573;7509040;7512959;7516890;7517665;7518558;7521687;7521878;7522622;7524079;7526393;7528218;7528327;7530449;7531291;7538118;7542404;7542572;7561031;7592958;760802;761607;7618087;7687428;7687539;7688784;7690834;7691807;7691959;7706301;7718892;7848918;7855889;7927516;7997270;803528;8071371;814163;8163536;8163559;8166770;8178173;8226994;8228618;8306975;8314844;8327478;8340414;8345200;8424694;8475064;8493579;8495193;8538770;8541526;8611682;8629002;8630736;8631904;8657103;8663278;8673706;8702662;8786315;8799126;8809042;8855948;8862523;8910399;8947047;8986718;8995416;8995445;9000504;9038722;9042338;9050880;9052782;9099726;9162098;9169774;9199344;9235916;9242610;9285412;9295288;9295361;9314552;9314561;9326643;9341187;9382878;9382888;9477973;9480991;9547345;9600938;9601638;9639556;9693095;9697839;9700512;9705280;9705962;971416;9730896;9763524;978134;9799231;9843499;9857068;9883880;9885284;9890995;9973503;9989831",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 4,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 589,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MS13",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 55.0,
        "record_id": "P01824-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P04553-1",
        "uniprot_id": [
            {
                "id": "HSP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P04553",
                "type": "external"
            }
        ],
        "mass": 6823.0,
        "length": 51,
        "protein_name": "Sperm protamine P1",
        "gene_name": "PRM1",
        "organism": "Human",
        "refseq_name": "sperm protamine P1",
        "refseq_ac": [
            {
                "id": "NP_002752",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRM1",
        "gene_names_refseq": "CT94.1; P1; PRM1",
        "protein_names_uniprotkb": "Sperm protamine P1; Cysteine-rich protamine",
        "protein_names_refseq": "cancer/testis antigen family 94, member 1; cysteine-rich protamine; sperm protamine P1; testicular tissue protein Li 91; testis specific protamine 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5619);  (R-HSA-9821993)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "10390541;10659848;2081589;22362753;2613245;3527226;36217675;3658707;36593375;37321532;38065301;38170186;4027356;7983046;8263493",
        "class_list": "",
        "function": "Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility., [RefSeq, PubMed]; Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter., [RefSeq, PubMed]; Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions., [RefSeq, PubMed]; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]; Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility., [RefSeq, PubMed]; Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030261 chromosome condensation;GO:0051276 chromosome organization;GO:0035092 sperm DNA condensation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P04553-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05015-1",
        "uniprot_id": [
            {
                "id": "IFN16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05015",
                "type": "external"
            }
        ],
        "mass": 21711.0,
        "length": 189,
        "protein_name": "Interferon alpha-16",
        "gene_name": "IFNA16",
        "organism": "Human",
        "refseq_name": "interferon alpha-16 precursor",
        "refseq_ac": [
            {
                "id": "NP_002164",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002164",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFNA16",
        "gene_names_refseq": "IFN-alpha-16; IFN-alphaO; IFNA16",
        "protein_names_uniprotkb": "Interferon alpha-16; IFN-alpha-16; Interferon alpha-WA",
        "protein_names_refseq": "IFN-alpha-N-protein; interferon alpha-16 precursor; interferon alpha-WA",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3449);  (R-HSA-909733);  (R-HSA-912694);  (R-HSA-933541);  (R-HSA-9705671);  (R-HSA-983231);  (R-HSA-9833109)",
        "pathway_count": 7,
        "publication_count": 185,
        "publication_id_list": "10022928;10395669;10421793;10542297;10581243;10982844;11042108;11062261;11073981;11092454;11242053;11337497;11377645;11404376;11585831;11694501;11744692;11751636;11895428;11950885;12019269;12029096;12032298;12133833;12134158;12427746;12604599;12692549;12759408;12766484;12842042;14769151;15020713;15047845;15208624;15247287;15312780;15361868;15449939;15710388;15778442;16009940;16054028;16125763;16127453;16153868;16171819;1630448;16710296;16914100;16987978;17027967;17196961;17251292;1730654;17327220;17351669;17392790;17969444;18035202;18508557;18575461;19193793;19293402;19479062;19668221;20043992;20130243;20363976;20530532;20574843;20627800;20643137;21632562;218813;2211721;22383950;22619329;22941947;23061660;23121362;23453971;24417533;24722368;25371710;26845023;30485383;30558248;31850239;32032529;32113509;32353859;32428392;32511913;32574262;32589897;32661006;32726803;32728199;32758689;32862111;32953130;32979938;33024073;33060197;33097660;33110251;33117408;33189161;33193462;33349665;33360543;33372174;33372854;33396578;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;3409321;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35102342;35381074;35643212;37051252;4057246;6162102;6387705;6548414;6548765;688397;7510216;7526154;7537377;7540766;8197134;8232552;8605876;8621447;8662638;8702790;8816476;8943354;9065479;9096384;9121453;9230307;9242679;9326583;9331217;9334213;9422515;9660177;9660935;9822609;9847332;9861020;9927674",
        "class_list": "",
        "function": "Cytokine pathway variants modulate platelet production: IFNA16 is a thrombocytosis susceptibility locus in humans., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VV12",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 18.6,
        "record_id": "P05015-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DP07-1",
        "uniprot_id": [
            {
                "id": "HV431_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DP07",
                "type": "external"
            }
        ],
        "mass": 13095.0,
        "length": 118,
        "protein_name": "Immunoglobulin heavy variable 4-31",
        "gene_name": "IGHV4-31",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV4-31",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 4-31",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11340299;17576170;20176268;22158414;23541343;24600447",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P0DP07-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P15516-1",
        "uniprot_id": [
            {
                "id": "HIS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P15516",
                "type": "external"
            }
        ],
        "mass": 6149.0,
        "length": 51,
        "protein_name": "Histatin-3",
        "gene_name": "HTN3",
        "organism": "Human",
        "refseq_name": "histatin-3 precursor",
        "refseq_ac": [
            {
                "id": "NP_000191",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000191",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HTN3; HIS2",
        "gene_names_refseq": "HIS2; HTN2; HTN3; HTN5; Hst 3; PB",
        "protein_names_uniprotkb": "Histatin-3; Basic histidine-rich protein; His3 1/11; His3 1/12; His3 1/13; His3 1/24; His3 1/25; His3 12/24; His3 12/25; His3 12/32; His3 13/24; His3 13/25; His3 14/24; His3 14/25; His3 15/24; His3 15/25; His3 26/32; His3 28/32; His3 29/32; His3 5/11; His3 5/12; His3 5/13; His3 6/11; His3 6/13; His3 7/11; His3 7/12; His3 7/13; His3-(1-11)-peptide; His3-(1-12)-peptide; His3-(1-13)-peptide; His3-(1-24)-peptide; His3-(1-25)-peptide; His3-(12-24)-peptide; His3-(12-25)-peptide; His3-(12-32)-peptide; His3-(13-24)-peptide; His3-(13-25)-peptide; His3-(14-24)-peptide; His3-(14-25)-peptide; His3-(15-24)-peptide; His3-(15-25)-peptide; His3-(26-32)-peptide; His3-(28-32)-peptide; His3-(29-32)-peptide; His3-(5-11)-peptide; His3-(5-12)-peptide; His3-(5-13)-peptide; His3-(6-11)-peptide; His3-(6-13)-peptide; His3-(7-11)-peptide; His3-(7-12)-peptide; His3-(7-13)-peptide; Histatin 10; Histatin 11; Histatin 12; Histatin 3; Histatin 4; Histatin 5; Histatin 6; Histatin 7; Histatin 8; Histatin 9; Histatin-10; Histatin-11; Histatin-12; Histatin-3 1/11; Histatin-3 1/12; Histatin-3 1/13; Histatin-3 1/24; Histatin-3 1/25; Histatin-3 12/24; Histatin-3 12/25; Histatin-3 12/32; Histatin-3 13/24; Histatin-3 13/25; Histatin-3 14/24; Histatin-3 14/25; Histatin-3 15/24; Histatin-3 15/25; Histatin-3 26/32; Histatin-3 28/32; Histatin-3 29/32; Histatin-3 5/11; Histatin-3 5/12; Histatin-3 5/13; Histatin-3 6/11; Histatin-3 6/13; Histatin-3 7/11; Histatin-3 7/12; Histatin-3 7/13; Histatin-4; Histatin-5; Histatin-6; Histatin-7; Histatin-8; Histatin-9; Histidine-rich protein 3; Hst 3; Hst 5; Hst; PB",
        "protein_names_refseq": "basic histidine-rich protein; histatin-3 precursor; histatin-4; histatin-5; histatin-6; histatin-7; histatin-8; histatin-9; histidine-rich protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3347);  (R-HSA-6803157)",
        "pathway_count": 2,
        "publication_count": 104,
        "publication_id_list": "10066791;10423240;11083804;11120840;11179305;11226423;11237011;11313366;11389039;11717389;11971875;12493837;12761219;12939362;13816;14506276;14739326;14966203;1522221;15229136;15272024;15485849;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16799473;16931762;16940129;17363965;17502600;17503797;17567961;17964057;18021746;18160480;18185531;18650243;18673279;18974864;19095652;19179970;19254208;19818633;19846304;20103720;20180804;20382864;20395631;20487276;20510021;20845358;20973643;21787330;22033918;22262861;22327069;22455996;22701042;23302724;23426625;2344289;23613860;2372245;24219363;24256734;24715725;25075772;25461571;25576301;25596890;26148048;26375851;26379655;26775844;27089320;2719677;27390786;28261570;28763199;29393594;29557506;29786170;31154438;31675138;32161166;32225006;32751915;3286634;33596477;3426601;35489730;36826226;7951254;8336540;8945538;9523110;9665269;9756476",
        "class_list": "",
        "function": "Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma., [RefSeq, PubMed]; Histatin 3 (Hst 3) is mostly involved in cell migration and wound healing in the oral cavity (PubMed:18650243). Also stimulates cell proliferation after binding to heat shock protein HSC70, which enhances HSC70-CDKN1B complex formation and subsequent ubiquitination during G1/S transition (PubMed:26775844). Also displays antifungal activity against pathogenic yeast Candida albicans, however with less effectiveness than Hst 5 (PubMed:11083804, PubMed:3286634)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Histatin 5 (Hst 5), a fragment of Hst 3, is the major histatin exhibiting antifungal and antibacterial activities (PubMed:10066791, PubMed:11083804, PubMed:11179305, PubMed:11717389, PubMed:12939362, PubMed:15485849, PubMed:2372245, PubMed:8945538). It is effective against pathogenic yeast C.albicans, C.neoformans, C.glabrata and S.cerevisiae as well as ESKAPE bacterial pathogens (PubMed:18974864, PubMed:23613860, PubMed:2372245, PubMed:28261570, PubMed:8945538). Secreted Hst 5 mediates a multi-step intracellular mechanism of action against the pathogen. Depending on peptide concentration and pathogen, uptake across the membrane can occur through transporters, direct interaction with plasma membrane and/or receptor-mediated endocytosis (PubMed:18974864, PubMed:20487276, PubMed:28261570). Binds C.albicans cell wall proteins SSA1 and SSA2 and glycans in an energy-independent manner, then is taken up by the cells through fungal polyamine transporters DUR3 and DUR31 in an energy-dependent manner (PubMed:12761219, PubMed:20487276, PubMed:22033918, PubMed:23613860). Internalized Hst5 is then targeted to the energized mitochondrion to induce reactive oxygen species (ROS) formation and subsequent release of intracellular non-lytic ATP which ultimately leads to fungal cell death (PubMed:10066791, PubMed:11083804, PubMed:11717389). In addition, inhibits C.albicans TRK1 potassium-transporter which causes exudation of intracellular K(+), generating an osmotic imbalance leading to delayed membrane lysis and cell death (PubMed:15485849). Also acts as a potent inhibitor of bacterial proteases such as Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis as well as human metalloproteases MMP2 and MMP9 (PubMed:11179305). The binding of metals such as zinc, copper or nickel with Hst 5 results in the protection of the enamel and antimicrobial activities such as the inhibition of microbial growth by decreasing the metal concentration, the formation of ROS commonly associated with redox-active metals, the induction of membrane disruption mediated by zinc binding (PubMed:19846304, PubMed:28261570, PubMed:28763199, PubMed:32751915). Also involved in coating oral surfaces in the form of a salivary film which reduces colonization by C.albicans on epithelial cell surfaces (PubMed:26379655). Secreted Hst 5 can also internalize mammalian epithelial cells and target the mitochondria although it does not exert cytotoxic effects in these cells (PubMed:32225006). In contrast with Hst 3, not able to promote wound healing in mammalian host cells (PubMed:18650243)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Histatin 5 variant reduces Candida albicans biofilm viability and inhibits biofilm formation., [RefSeq, PubMed]; Histatins are cationic and histidine-rich peptides mainly found in the saliva of higher primates (PubMed:3286634). They are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their biological functions: antimicrobial Hsts (e.g. Hst 5/HTN3) and cell-activating Hsts (e.g. Hst 1/HTN1, Hst 2/HTN1 and Hst 3/HTN3) (PubMed:32225006)., [UniProtKB, PubMed, PubMed]; Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci., [RefSeq, PubMed]; This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16243;Q502Z1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0090303 positive regulation of wound healing;GO:0042742 defense response to bacterium;GO:0048146 positive regulation of fibroblast proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P15516-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P17483-1",
        "uniprot_id": [
            {
                "id": "HXB4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P17483",
                "type": "external"
            }
        ],
        "mass": 27604.0,
        "length": 251,
        "protein_name": "Homeobox protein Hox-B4",
        "gene_name": "HOXB4",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-B4",
        "refseq_ac": [
            {
                "id": "NP_076920",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076920",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HOXB4; HOX2F",
        "gene_names_refseq": "HOX-2.6; HOX2F; HOX2; HOXB4",
        "protein_names_uniprotkb": "Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F",
        "protein_names_refseq": "homeo box 2F; homeo box B4; homeobox protein Hox-2.6; homeobox protein Hox-2F; homeobox protein Hox-B4",
        "tax_id": 9606,
        "disease": "leukemia (Disease Ontology:DOID:1240)",
        "pathway": " (hsa:3214);  (R-HSA-5617472);  (R-HSA-9830364)",
        "pathway_count": 3,
        "publication_count": 82,
        "publication_id_list": "10777502;11085749;15867264;16079151;16549775;17185360;17428788;1756725;17660710;17713478;17761849;17851529;18781158;19115252;19232136;19747919;1975088;19782034;1981366;19854132;20085832;22569366;22705304;22879880;23186163;23219899;23534758;23630040;24174538;24312487;24586203;24715725;25101834;25135475;2570724;2576652;25880248;25913784;26154972;26992070;27846572;27920218;28063628;28832583;28834231;29242379;29508533;29557506;30410026;30419846;31844290;31937595;32157095;32161166;32178630;32265295;32502341;32938616;32983136;33141586;33298915;33479226;33936100;33968037;33981976;34211107;34932366;35051231;36010968;36415199;36581221;38182548;7488013;7501971;7831296;7906964;7908827;8674428;8759021;9218805;9272954;9482740",
        "class_list": "",
        "function": "HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/beta-catenin signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; HOXB4 promotes the malignant progression of ovarian cancer via DHDDS. Publication Status: Online-Only, [RefSeq, PubMed]; LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc., [RefSeq, PubMed]; Our data confirms that CaP growth and chemo-/radioresistance in vivo is associated with over-expression of EpCAM, which serves both a functional biomarker and promising therapeutic target. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]., [RefSeq]; [miRNA-181a-5p inhibits proliferation and migration of osteosarcoma cell line HOS by targeting HOXB4]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NTA0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "P17483-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23083-1",
        "uniprot_id": [
            {
                "id": "HV102_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23083",
                "type": "external"
            }
        ],
        "mass": 13085.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1-2",
        "gene_name": "IGHV1-2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHV1-2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-2; Ig heavy chain V-I region ND; Ig heavy chain V-I region V35",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
        "pathway_count": 19,
        "publication_count": 539,
        "publication_id_list": "10026222;10051622;10068651;10072481;1008494;10087012;10219243;10224668;10381560;10395673;10432293;10496324;10498607;10499918;10523831;10531307;10556826;10559936;10575277;10579907;10606205;10648173;1067618;10702308;10706702;10724160;10746781;10764623;10770799;10781580;1081164;10838074;10860980;10861086;10878810;10880360;10882101;10917520;10925294;10983984;10995437;11007481;11015619;11030334;11042164;11071869;11090634;11157975;11196644;11207550;11226282;11231582;11256994;11265639;11276226;11278486;11306453;11325957;11329366;11340081;11340169;11340299;11368773;11395409;11425868;11449366;11460167;11489943;11513152;11553796;11556966;11564780;11606584;11694537;11713268;11747816;11749377;11772397;11779189;11804587;11807247;11812992;11829459;11854399;11857637;11858820;11861603;11877257;11901194;11909947;11939578;11955593;11955595;11955599;11994425;12055245;12055636;12070135;12105426;12117970;12181444;12189515;12208882;12213210;12213321;12217391;12235133;12396008;12417718;12453414;12456653;12469115;12473184;12483297;1249422;1252417;12573241;12588680;12660731;12670394;12670955;12743368;12782713;12869549;12975316;1314888;13342742;13472068;1372004;1372019;1374290;1375264;1376928;1386357;14280442;14514672;14529530;14615387;14630197;14676198;14719373;14970179;15000751;15010370;15034010;15040784;15125833;15136729;15155468;15161916;15187135;15187158;15199963;15294978;15304001;15327770;15448162;15452139;1550550;15509800;15528364;15534202;15536084;15541655;15542058;15548136;15580655;15607800;15657136;15681301;15686303;15697213;15721307;15778510;15781451;15800062;15809313;15851719;15864273;15879134;1591491;15947085;1599430;16014749;16046400;16079145;16091383;16115318;16129954;16186825;16189277;16192651;16252004;16258728;16262445;16297198;16339513;16356853;16356856;16380601;16408005;16456001;1646599;16497229;16522641;16546099;16551255;16585556;16641196;16678913;16691243;16702231;16737824;16737840;16754721;16778136;16783819;16831874;16849466;16880808;16893496;16904340;16906149;16921024;16928187;16938345;16978534;16999828;17008602;1702903;17045824;17047224;1705565;17057721;17064312;17099249;17102136;17116209;17135271;17158449;17167768;17172599;17182573;17188549;17202194;17224452;17237375;17308335;17322099;17337780;17379836;17428801;17442946;17452328;17452516;17486119;17496917;17498065;17502104;17505016;17505110;17525755;17540168;17563375;17576170;17580308;17590538;17600130;17615384;17625065;17662961;17845074;17947238;17948050;17993265;18006696;18025150;18031695;18037897;18052078;18055229;18070890;18187424;18209062;18234675;18296442;18326500;18391171;18420269;18556779;18593354;18596693;18772140;18818202;18843204;18995841;19124833;19149696;19206206;19249086;19279206;19324878;19359216;19372136;19574218;19592130;19592646;19650691;19741094;19909365;19955216;2011584;20176268;20192804;20223979;20300203;20430887;20685844;20730098;20920479;21037092;21193412;21241660;21408196;21419341;21469132;21653832;21659548;21788512;21800138;21822214;21841309;21877119;21966355;22158414;22180443;22210847;22396535;22401777;22492620;22552008;22798961;22802338;22814904;22922649;2303036;2304550;23487775;23641311;23675550;23695528;23836650;23929856;23945545;24043627;2420889;24272870;24305946;24584101;24600447;2465906;2466593;2474607;24764293;2481448;25200415;2529342;2538457;25703557;25716998;25801024;26002965;26284469;26300885;26992070;2806549;2833500;2833705;2841108;28425720;293688;293746;2956252;2971659;29945920;301546;30201761;31048504;32983136;34932366;3500860;35051231;3848661;3891754;4074707;4098172;4327491;4589993;468991;496916;5135507;6019133;6214588;6219696;6222381;6230668;6238120;6334079;6335036;6454142;6480598;6607952;670886;6815656;6849882;6906228;702059;70787;7263686;7287740;7378053;7391570;7391573;7509040;7512959;7516890;7517665;7518558;7521687;7521878;7522622;7524079;7526393;7528218;7528327;7530449;7531291;7538118;7542404;7542572;7561031;7592958;760802;761607;7618087;7681398;7687428;7687539;7688784;7690834;7691807;7691959;7706301;7718892;7848918;7855889;7927516;7997270;803528;8071371;814163;8163536;8163559;8166770;8178173;8226994;8228618;8306975;8314844;8327478;8340414;8345200;8424694;8475064;8493579;8495193;8538770;8541526;8611682;8629002;8630736;8631904;8657103;8663278;8673706;8702662;8786315;8799126;8809042;8855948;8862523;8910399;8947047;8986718;8995416;8995445;9000504;9038722;9042338;9050880;9052782;9099726;9162098;9169774;9199344;9235916;9242610;9285412;9295288;9295361;9314552;9314561;9326643;9341187;9382878;9382888;9477973;9480991;9547345;9600938;9601638;9639556;9693095;9697839;9700512;9705280;9705962;971416;9730896;9763524;978134;9799231;9843499;9857068;9883880;9885284;9890995;9973503;9989831",
        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 566,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WSX2;P01744",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 54.0,
        "record_id": "P23083-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00001",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31275-1",
        "uniprot_id": [
            {
                "id": "HXC12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31275",
                "type": "external"
            }
        ],
        "mass": 30171.0,
        "length": 282,
        "protein_name": "Homeobox protein Hox-C12",
        "gene_name": "HOXC12",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-C12",
        "refseq_ac": [
            {
                "id": "NP_776272",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776272",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HOXC12; HOC3F; HOX3F",
        "gene_names_refseq": "HOC3F; HOX3F; HOX3; HOXC12",
        "protein_names_uniprotkb": "Homeobox protein Hox-C12; Homeobox protein Hox-3F",
        "protein_names_refseq": "homeo box 3F; homeo box C12; homeobox protein Hox-3F; homeobox protein Hox-C12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3228)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11857506;2574852;26729820",
        "class_list": "",
        "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; The microdeletions share a minimal non-coding region overlap upstream of HOXC13, with variable phenotypes depending upon HOXC13, HOXC12 or the HOTAIR lncRNA inclusion. Identification of 5' HOXC microdeletions highlights the importance of transcriptional regulators in the aetiology of severe lower limb malformations and will improve their diagnosis and management, [RefSeq, PubMed]; This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BXJ6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "P31275-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31277-1",
        "uniprot_id": [
            {
                "id": "HXD11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31277",
                "type": "external"
            }
        ],
        "mass": 35197.0,
        "length": 338,
        "protein_name": "Homeobox protein Hox-D11",
        "gene_name": "HOXD11",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-D11",
        "refseq_ac": [
            {
                "id": "NP_067015",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067015",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HOXD11; HOX4F",
        "gene_names_refseq": "HOX4F; HOX4; HOXD11",
        "protein_names_uniprotkb": "Homeobox protein Hox-D11; Homeobox protein Hox-4F",
        "protein_names_refseq": "Hox-4.6, mouse, homolog of; homeo box 4F; homeo box D11; homeobox protein Hox-4F; homeobox protein Hox-D11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3237);  (R-HSA-9830674)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "17236141;18767875;20068231;2574852;27363011;27658780;31217245;34185709;35051231;36151071;38253038;38308324",
        "class_list": "",
        "function": "High expression of HOXD11 is associated with laryngeal squamous cell carcinoma., [RefSeq, PubMed]; Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development. Publication Status: Online-Only, [RefSeq, PubMed]; Knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway., [RefSeq, PubMed]; MiR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIS4;Q9NS02",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009953 dorsal/ventral pattern formation;GO:0001658 branching involved in ureteric bud morphogenesis;GO:0060272 embryonic skeletal joint morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P31277-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P38567-1",
        "uniprot_id": [
            {
                "id": "HYALP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P38567",
                "type": "external"
            }
        ],
        "mass": 57848.0,
        "length": 509,
        "protein_name": "Hyaluronidase PH-20",
        "gene_name": "SPAM1",
        "organism": "Human",
        "refseq_name": "hyaluronidase PH-20 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001167515",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167515",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPAM1; HYAL3; PH20",
        "gene_names_refseq": "HEL-S-96n; HYA1; HYAL5; PH-20; PH20; SPAG15; SPAM1",
        "protein_names_uniprotkb": "Hyaluronidase PH-20; 3.2.1.35; Hyal-PH20; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20",
        "protein_names_refseq": "epididymis secretory sperm binding protein Li 96n; hyal-PH20; hyaluronidase PH-20 isoform 2; hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm surface protein PH-20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6677);  (R-HSA-2160916);  (R-HSA-2534343)",
        "pathway_count": 3,
        "publication_count": 33,
        "publication_id_list": "11237011;11350981;11568288;14514708;15035633;15090545;15503855;15510212;16104017;17050540;20364096;21248752;22142621;23509262;24778442;25209425;2971395;31154438;33392160;34087483;34326835;34520755;3468507;35051231;35494241;37833433;8195297;8234258;8282124;8575780;8901634;9288901;9712871",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice., [RefSeq, PubMed]; Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]., [RefSeq]; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid., [UniProtKB, PubMed]; Low acrosin activity is associated with decreased Spam1/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells., [RefSeq, PubMed]; N-Glycosylation and enzymatic activity of the rHuPH20 expressed in Chinese hamster ovary cells., [RefSeq, PubMed]; Results indicate that neither rHuPH20 nor its directly generated HA catabolites have inflammatory properties in the air pouch model, and rHuPH20 can instead inhibit some aspects of inflammation, such as neutrophil infiltration into the air pouch., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 731,
        "reported_interactions": 1,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 1,
        "secondary_ac_list": "Q8TC30",
        "ec_number_list": [
            {
                "id": "3.2.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0005975 carbohydrate metabolic process;GO:0030214 hyaluronan catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "P38567-1",
        "record_type": "protein",
        "filter_code": "0000000.1101101.100000.000000000001000000.1000000010001.101.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14627-1",
        "uniprot_id": [
            {
                "id": "I13R2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14627",
                "type": "external"
            }
        ],
        "mass": 44176.0,
        "length": 380,
        "protein_name": "Interleukin-13 receptor subunit alpha-2",
        "gene_name": "IL13RA2",
        "organism": "Human",
        "refseq_name": "interleukin-13 receptor subunit alpha-2 precursor",
        "refseq_ac": [
            {
                "id": "NP_000631",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000631",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL13RA2; IL13R",
        "gene_names_refseq": "CD213A2; CT19; IL-13R; IL13BP; IL13RA2",
        "protein_names_uniprotkb": "Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; Interleukin-13-binding protein",
        "protein_names_refseq": "IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; cancer/testis antigen 19; interleukin 13 binding protein; interleukin 13 receptor alpha 2 chain; interleukin 13 receptor, alpha 2; interleukin-13 receptor subunit alpha-2 precursor",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); pneumonia (Disease Ontology:DOID:552); pulmonary hypertension (Disease Ontology:DOID:6432); steatotic liver disease (Disease Ontology:DOID:9452)",
        "pathway": " (hsa:3598);  (R-HSA-6785807)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "10023775;10219247;10369418;10510379;10586089;10867011;11058569;11084045;11104795;11120780;11278437;11278729;11356008;11404481;11463377;11861389;11960372;12223527;12242343;12600988;12832402;14634100;14712222;15116091;15261459;15584925;15805299;15869882;15950906;16007214;16048438;16107692;16205632;16236134;16327802;16397018;16451196;16510571;16540365;16606674;17030238;17427945;17458857;17572495;17719173;18243101;18353781;18447642;18644974;18694590;19124156;19185846;19397496;20223216;20493732;21102457;21252155;21689689;21730069;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23455323;23555662;23967200;24097101;24743777;25234944;27600516;31222486;31844290;32098194;32157095;32488085;32938616;33592498;33968037;34544797;36228153;36757802;36806727;7510216;7512451;7529288;7795521;7796300;7898939;7907877;8085155;8602263;8621622;8663118;8668165;8797861;8816495;9013879;9177784;9651359;9723655;9736340;9822675;9874564",
        "class_list": "",
        "function": "Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation (PubMed:11861389, PubMed:17030238). Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1 (PubMed:16327802)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation. Publication Status: Online-Only, [RefSeq, PubMed]; IL13Ralpha2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases., [RefSeq, PubMed]; Identification of the alpha2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models., [RefSeq, PubMed]; The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 10,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7E2;O00667",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006915 apoptotic process;GO:0050728 negative regulation of inflammatory response;GO:0070371 ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "Q14627-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14773-1",
        "uniprot_id": [
            {
                "id": "ICAM4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14773",
                "type": "external"
            }
        ],
        "mass": 29265.0,
        "length": 271,
        "protein_name": "Intercellular adhesion molecule 4",
        "gene_name": "ICAM4",
        "organism": "Human",
        "refseq_name": "intercellular adhesion molecule 4 isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001034221",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034221",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICAM4; LW",
        "gene_names_refseq": "CD242; ICAM4; LW",
        "protein_names_uniprotkb": "Intercellular adhesion molecule 4; ICAM-4; LW blood group protein; Landsteiner-Wiener blood group glycoprotein",
        "protein_names_refseq": "CD242 antigen; LW antigen a; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; bloodgroup LW protein; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 precursor",
        "tax_id": 9606,
        "disease": "obsolete blood group system, landsteiner-wiener (MONDO:MONDO:0020615)",
        "pathway": " (hsa:3386);  (R-HSA-198933);  (R-HSA-216083)",
        "pathway_count": 3,
        "publication_count": 165,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10209034;10366422;10438935;10499918;10543983;10593924;10605720;10640428;10673366;10713152;10746781;10811134;10846180;10982388;11158588;11265639;11435317;11489943;11513152;11518510;11556966;11572855;11713259;11807247;11857637;11858820;11861603;11955593;11955595;11955599;11980922;12213321;12477717;12483297;12496264;12585966;12588680;12682293;12807887;14719373;14970179;15034010;15136729;15155468;15187158;15240572;15304001;15330449;15345499;15355350;15383545;15534202;15541655;15580655;15607800;15713743;15778510;15781451;15800062;15851719;15864273;1588291;15899827;16002701;16014749;16051604;16091383;16129954;16239428;16339513;16380601;16551255;16731529;16737824;16754661;16754721;16893496;16904340;16928187;16933105;16985175;17045824;17057721;17237375;17337780;17339034;17968485;18031695;18037897;18055229;18209062;18234675;18593354;18710925;18775695;19149696;19359216;19502598;19592130;20033473;2010551;20705068;20730098;21241660;21800138;21841309;21877119;22396535;22539938;22884367;23374253;23695528;23929856;24305946;25703557;25716998;25813380;26137540;26284469;26300885;26992070;28076805;28904123;29242379;29557506;31844290;32350084;32387766;32938616;33912179;35051231;35154160;35251023;36708580;38015525;38253038;7505120;7525578;7531291;7541634;7542249;7542404;7559467;7632968;7685013;8118028;8178173;8202485;8344274;8560266;8639917;8798654;8838667;8910476;8995416;9251239;9285412;9314561;9443892;9565552;9700512;9730896;9858236",
        "class_list": "",
        "function": "Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. Publication Status: Online-Only, [RefSeq, PubMed]; DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis (PubMed:16985175). Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed:12477717, PubMed:15355350). In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes (PubMed:10846180, PubMed:11435317, PubMed:15355350)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Immunological Study of IFN-gamma, ICAM-4, and Vitamin D3 Markers among Gastrointestinal Tumor Patients in Babylon Province, Iraq. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation, [RefSeq, PubMed]; This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0M8X2;Q14771;Q14772;Q16375;Q9BWR0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0006909 phagocytosis;GO:0033631 cell-cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion;GO:0034113 heterotypic cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "Q14773-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16270-1",
        "uniprot_id": [
            {
                "id": "IBP7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16270",
                "type": "external"
            }
        ],
        "mass": 29130.0,
        "length": 282,
        "protein_name": "Insulin-like growth factor-binding protein 7",
        "gene_name": "IGFBP7",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor-binding protein 7 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001240764",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240764",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGFBP7; MAC25; PSF",
        "gene_names_refseq": "AGM; FSTL2; IBP-7; IGFBP-7v; IGFBP-7; IGFBP7; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF",
        "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; TAF; Tumor-derived adhesion factor",
        "protein_names_refseq": "IGF-binding protein 7; IGFBP-rP1; PGI2-stimulating factor; angiomodulin; insulin-like growth factor-binding protein 7 isoform 2 precursor; prostacyclin-stimulating factor; tumor-derived adhesion factor",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); renal cell carcinoma (Disease Ontology:DOID:4450); familial retinal arterial macroaneurysm (MONDO:MONDO:0013640)",
        "pathway": " (hsa:3490);  (R-HSA-2559582);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 4,
        "publication_count": 122,
        "publication_id_list": "10.1038/emboj.2013.79;10026136;10077652;10218588;10432220;10512690;10548110;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11114305;11158056;11250653;11264294;11316783;11340163;11522292;11549700;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12832467;12904166;1370451;1383255;14679213;15126567;15308688;15340161;15469690;15485880;15525596;15642270;15774718;16626623;17047378;17249697;17312271;17985932;18267069;18411265;18555777;18555778;18772245;19805069;20351173;20452968;2183031;21835307;21979375;22178396;22634325;23584533;23846687;2405250;24706756;2476804;2479552;25502872;25576301;26091039;27862975;29557506;29786170;30429286;30459171;31154438;31844290;32157095;32387766;33592498;33968037;35051231;36241641;37304887;37316358;37714372;37938771;38218180;38665916;38840498;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;7694637;7980422;8117260;8234276;8384717;8413215;8413306;8617720;8688489;8781553;8817670;8884985;8894645;8939459;8939990;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180)., [UniProtKB, PubMed, PubMed]; Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis., [RefSeq, PubMed]; IGFBP-7 secreted by adipose-derived stem cells inhibits keloid formation via the BRAF/MEK/ERK signaling pathway., [RefSeq, PubMed]; IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury., [RefSeq, PubMed]; Structural insight into CD93 recognition by IGFBP7., [RefSeq, PubMed]; The diagnostic value of serum insulin-like growth factor binding protein 7 in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 17,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 17,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 17,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E1N2;B7Z9W7;Q07822;Q53YE6;Q9UCA8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0071380 cellular response to prostaglandin E stimulus;GO:0032526 response to retinoic acid",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "Q16270-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2VIR3-1",
        "uniprot_id": [
            {
                "id": "IF2GL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2VIR3",
                "type": "external"
            }
        ],
        "mass": 51229.0,
        "length": 472,
        "protein_name": "Eukaryotic translation initiation factor 2 subunit 3B",
        "gene_name": "EIF2S3B",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 2 subunit 3B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001344660",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001344660",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EIF2S3B",
        "gene_names_refseq": "EIF2S3B; EIF2S3L; eIF-2gA; eIF2gA",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3B; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma A; eIF-2-gamma A; eIF-2gA",
        "protein_names_refseq": "eIF-2-gamma2; eukaryotic translation initiation factor 2 subunit 3B isoform 2; eukaryotic translation initiation factor 2 subunit 3B; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; putative eukaryotic translation initiation factor 2 subunit 3-like protein",
        "tax_id": 9606,
        "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)",
        "pathway": " (hsa:255308)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "16201836;17697703;22424782;22544926;22898188;23481700;24029068;24366607;24714562;25418920;25576336;25645385;25802875;25880248;25892735;26024233;26375851;27600516;27920218;28063628;28218747;28228285;28446606;28514659;28649982;28832583;28834231;28904123;29242379;29393594;29508533;29632046;29632711;29786170;29789417;30315122;30379171;30410026;30429286;30484775;30524438;32265295;32387766;32502341;33123756;33141586;33392160;33537174;33981976;34357683;35083852;9029102;9736774",
        "class_list": "",
        "function": "Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8W810;Q5I0X0;Q6KF84",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0005850 eukaryotic translation initiation factor 2 complex",
        "go_biological_process": "GO:0001731 formation of translation preinitiation complex",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q2VIR3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IS14-1",
        "uniprot_id": [
            {
                "id": "IF5AL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IS14",
                "type": "external"
            }
        ],
        "mass": 16773.0,
        "length": 154,
        "protein_name": "Eukaryotic translation initiation factor 5A-1-like",
        "gene_name": "EIF5AL1",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 5A-1-like",
        "refseq_ac": [
            {
                "id": "NP_001093162",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093162",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EIF5AL1",
        "gene_names_refseq": "EIF5AL1; EIF5AP1",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-1-like; Eukaryotic initiation factor 5A isoform 1-like; eIF-5A-1-like; eIF-5A1-like",
        "protein_names_refseq": "eukaryotic translation initiation factor 5A-1-like",
        "tax_id": 9606,
        "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:143244)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "22706990;25810538;27452731;27600516;28218747;28228285;28832583;28834231;29242379;29393594;29508533;29557506;29632711;29786170;29789417;30132996;30192525;30315122;30379171;31611695;32502341;33123756;33141586;33981976;34357683;37047039",
        "class_list": "",
        "function": "Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability. Publication Status: Online-Only, [RefSeq, PubMed]; EIF5AL1 expression is associated with colorectal cancer metastasis., [RefSeq, PubMed]; Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006414 translational elongation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q6IS14-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UWB1-1",
        "uniprot_id": [
            {
                "id": "I27RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UWB1",
                "type": "external"
            }
        ],
        "mass": 69474.0,
        "length": 636,
        "protein_name": "Interleukin-27 receptor subunit alpha",
        "gene_name": "IL27RA",
        "organism": "Human",
        "refseq_name": "interleukin-27 receptor subunit alpha precursor",
        "refseq_ac": [
            {
                "id": "NP_004834",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004834",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL27RA; CRL1; PRO336; TCCR; WSX1",
        "gene_names_refseq": "CRL1; IL-27RA; IL27RA; IL27R; TCCR; WSX1; zcytor1",
        "protein_names_uniprotkb": "Interleukin-27 receptor subunit alpha; Cytokine receptor WSX-1; Cytokine receptor-like 1; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; TCCR; Type I T-cell cytokine receptor; ZcytoR1",
        "protein_names_refseq": "IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; T-cell cytokine receptor type 1; class I cytokine receptor; cytokine receptor WSX-1; cytokine receptor-like 1; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha precursor; type I T-cell cytokine receptor",
        "tax_id": 9606,
        "disease": "systemic scleroderma (Disease Ontology:DOID:418); immunodeficiency 134 (Epstein-Barr virus-specific) (MONDO:MONDO:0980729)",
        "pathway": " (hsa:9466);  (R-HSA-8984722);  (R-HSA-9020956)",
        "pathway_count": 3,
        "publication_count": 85,
        "publication_id_list": "10.1101/2023.09.13.557529;11057672;12121660;12734330;12829785;12975309;14565860;14764690;16324152;17874423;18033300;18292512;18389480;19386761;19933857;20519510;21631431;22306691;22487722;22814351;23481700;23555621;24058793;24572363;24715725;24743305;24771852;25502872;25505266;25576301;25892735;25992861;26154972;26279360;27119567;27846572;27862975;27920218;28218747;28228285;28467828;28832583;28871256;28904123;29242379;29437277;29493099;29557506;29632711;30315122;30410026;30573663;31092671;31154438;31530632;31844290;31937595;31998317;32161166;32350084;32502341;32938616;33043033;33141586;33298915;33592498;33912179;33936100;33968037;34357683;34433824;34932366;35051231;35154160;35251023;35379743;35723626;35920255;36241641;36867577;36930708;38509369;8483502;9342359;9600072",
        "class_list": "",
        "function": "Cytokine receptor IL27RA is an NF-kappaB-responsive gene involved in CD38 upregulation in multiple myeloma., [RefSeq, PubMed]; IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma., [RefSeq, PubMed]; In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]., [RefSeq]; Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency., [RefSeq, PubMed]; Signal-transducing subunit for an heterodimeric cytokine composed of IL27/p28 and a soluble receptor EBI3 (PubMed:14764690, PubMed:36930708). Heterodimerizes with IL6ST/GP130 to mediate signal transduction in response to the heterodimeric cytokine IL27/p28-EBI3. This signaling system acts through STAT3 and STAT1 (PubMed:14764690, PubMed:38509369). Also acts as a signaling receptor as part of the humanin receptor complex; binding of MT-RNR2/humanin (HN) activates the intracellular JAK-STAT3 signaling pathway leading to neuroprotection (PubMed:19386761). Involved in the regulation of Th1-type immune responses (By similarity). Also appears to be involved in innate defense mechanisms (PubMed:14764690)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Structural insights into the assembly and activation of the IL-27 signaling complex., [RefSeq, PubMed]; WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation., [RefSeq, PubMed]; WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 9481,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 2,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0N0L1;O60624",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0045509 interleukin-27 receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:2000317 negative regulation of T-helper 17 type immune response;GO:0032700 negative regulation of interleukin-17 production;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q6UWB1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UWQ7-1",
        "uniprot_id": [
            {
                "id": "IGFL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UWQ7",
                "type": "external"
            }
        ],
        "mass": 13248.0,
        "length": 119,
        "protein_name": "Insulin growth factor-like family member 2",
        "gene_name": "IGFL2",
        "organism": "Human",
        "refseq_name": "insulin growth factor-like family member 2 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001002915",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002915",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGFL2; PRO1275",
        "gene_names_refseq": "IGFL2; UNQ645; VPRI645",
        "protein_names_uniprotkb": "Insulin growth factor-like family member 2",
        "protein_names_refseq": "insulin growth factor-like family member 2 isoform a precursor; insulin growth factor-like family member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:147920)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;12975309;16890402;21454693",
        "class_list": "",
        "function": "IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]., [RefSeq]; Potential ligand of the IGFLR1 cell membrane receptor., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PAV1;Q6B9Z3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6UWQ7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UWX4-1",
        "uniprot_id": [
            {
                "id": "HIPL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UWX4",
                "type": "external"
            }
        ],
        "mass": 80779.0,
        "length": 724,
        "protein_name": "HHIP-like protein 2",
        "gene_name": "HHIPL2",
        "organism": "Human",
        "refseq_name": "HHIP-like protein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_079022",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079022",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HHIPL2; HHIP3; KIAA1822L; PRO1779",
        "gene_names_refseq": "HHIPL2; KIAA1822L",
        "protein_names_uniprotkb": "HHIP-like protein 2",
        "protein_names_refseq": "HHIP-like protein 2 precursor; HHIP-like protein 2; hedgehog interacting protein-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79802)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "10.1101/2023.09.13.557529;12975309;16391842;22237814;33592498;35051231",
        "class_list": "",
        "function": "HHIPL-2 was identified as a candidate gene involved in iron-related modulation of osteoblast markers., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GU65;Q96BT4;Q96BU5;Q9H8A0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q6UWX4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UXB1-1",
        "uniprot_id": [
            {
                "id": "IGFL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UXB1",
                "type": "external"
            }
        ],
        "mass": 14198.0,
        "length": 125,
        "protein_name": "Insulin growth factor-like family member 3",
        "gene_name": "IGFL3",
        "organism": "Human",
        "refseq_name": "insulin growth factor-like family member 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_997276",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997276",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGFL3; PRO982",
        "gene_names_refseq": "IGFL3; UNQ483",
        "protein_names_uniprotkb": "Insulin growth factor-like family member 3",
        "protein_names_refseq": "RPRC483; insulin growth factor-like family member 3 precursor; insulin growth factor-like family member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388555)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "12975309;15340161;16890402;21454693;28005267",
        "class_list": "",
        "function": "IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]., [RefSeq]; IGFL3 expression is significantly downregulated in human masticatory mucosa during wound healing, [RefSeq, PubMed]; Potential ligand of the IGFLR1 cell membrane receptor., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q6UXB1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZQW0-1",
        "uniprot_id": [
            {
                "id": "I23O2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZQW0",
                "type": "external"
            }
        ],
        "mass": 45424.0,
        "length": 407,
        "protein_name": "Indoleamine 2,3-dioxygenase 2",
        "gene_name": "IDO2",
        "organism": "Human",
        "refseq_name": "indoleamine 2,3-dioxygenase 2",
        "refseq_ac": [
            {
                "id": "NP_001382135",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382135",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IDO2; INDOL1",
        "gene_names_refseq": "IDO2; INDOL1",
        "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 2; 1.13.11.-; IDO-2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1",
        "protein_names_refseq": "indoleamine 2,3-dioxygenase 2; indoleamine 2,3-dioxygenase-like 1 protein; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine-pyrrole 2,3-dioxygenase-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:169355);  (R-HSA-71240)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10049700;10391915;10672018;12007602;12140278;13069505;15364907;15880762;16376499;16477023;17499941;17671174;18056995;18262359;18418598;18620547;19338303;19476837;19487973;21097500;23478338;25394548;25477879;25691885;25950090;28228285;28832583;29242379;29632711;36319978;37408267;37506544;38003426;38460493;7514594;7883047;8294935;8666386;9180257",
        "class_list": "",
        "function": "Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]., [RefSeq]; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885)., [UniProtKB, PubMed, PubMed]; First study to report IDO2 expression in pancreatic ductal adenocarcinoma indicating that IDO2 genetic polymorphisms do not negate interferon-gamma-inducible protein expression. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients., [RefSeq, PubMed]; IDO2 encodes a novel IDO-related tryptophan catabolic enzyme that is preferentially inhibited by D-1-methyl-tryptophan (D-1MT).  IDO2 may have a distinct role in immune tolerance. Two common human genetic polymorphisms ablate IDO2 enzyme activity., [RefSeq, PubMed]; Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects. Publication Status: Online-Only, [RefSeq, PubMed]; Marked IDO2 expression and activity related to autophagy and apoptosis in brain tissue of fatal tuberculous meningitis., [RefSeq, PubMed]; Membrane Localization and Phosphorylation of Indoleamine 2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells: First Steps in Exploring Its Signaling Function. Publication Status: Online-Only, [RefSeq, PubMed]; Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection., [RefSeq, PubMed]; Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This article describes the evolutionary relationships between the INDO and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO and both have the ability to catabolise tryptophan. Erratum:[Gene. 2010 Oct 1;465(1-2):66], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4UD41;F5H5G0",
        "ec_number_list": [
            {
                "id": "1.13.11.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52",
                "type": "external"
            },
            {
                "id": "1.13.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity;GO:0033754 indoleamine 2,3-dioxygenase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0002376 immune system process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q6ZQW0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YZ3-1",
        "uniprot_id": [
            {
                "id": "HORN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YZ3",
                "type": "external"
            }
        ],
        "mass": 282390.0,
        "length": 2850,
        "protein_name": "Hornerin",
        "gene_name": "HRNR",
        "organism": "Human",
        "refseq_name": "hornerin",
        "refseq_ac": [
            {
                "id": "NP_001009931",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009931",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HRNR; S100A18",
        "gene_names_refseq": "FLG3; HRNR; S100A16; S100a18",
        "protein_names_uniprotkb": "Hornerin",
        "protein_names_refseq": "filaggrin family member 3; hornerin; intermediate filament-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388697);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "15507446;19020553;19601998;20068231;21282207;23271734;23650620;23751202;24275569;25880248;26374642;26375851;26853435;27452731;27893789;28218747;28510447;28649982;28855257;29317506;29393594;29557506;30103712;30256937;30524438;31020640;31061102;31611695;31844290;32162841;32350084;32387766;33043033;33091337;34019948;34078123;34229054;34357683;35051231;35251023;35561310;36263704;37217939;38123340;38253038;38665916;39990658;8692836",
        "class_list": "",
        "function": "Component of the epidermal cornified cell envelopes., [UniProtKB, PubMed]; Expression of hornerin in skin lesions of atopic dermatitis and skin diseases., [RefSeq, PubMed]; HRNR is expressed in healthy skin and contributes to its barrier function, [RefSeq, PubMed]; HRNR promotes tumor progression and is correlated with a poor hepatocellular carcinoma (HCC)prognosis. HRNR may contribute to HCC progression via the regulation of the AKT pathway. Publication Status: Online-Only, [RefSeq, PubMed]; High order repeat formation conserved in apes Publication Status: Online-Only, [RefSeq, PubMed]; Hornerin is expressed in regenerating and psoriatic skin, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor., [RefSeq, PubMed]; The data demonstrate that HRNR is a component of cornified cell envelopes of human epidermis. Its reduced expression in AD may contribute to the epidermal barrier defect observed in the disease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 23,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 158,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5DT20;Q5U1F4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0031424 keratinization;GO:0061436 establishment of skin barrier;GO:0043163 cell envelope organization",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q86YZ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N6P7-1",
        "uniprot_id": [
            {
                "id": "I22R1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N6P7",
                "type": "external"
            }
        ],
        "mass": 63077.0,
        "length": 574,
        "protein_name": "Interleukin-22 receptor subunit alpha-1",
        "gene_name": "IL22RA1",
        "organism": "Human",
        "refseq_name": "interleukin-22 receptor subunit alpha-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_067081",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067081",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL22RA1; IL22R",
        "gene_names_refseq": "CRF2-9; IL22R1; IL22RA1; IL22R",
        "protein_names_uniprotkb": "Interleukin-22 receptor subunit alpha-1; CRF2-9; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ZcytoR11",
        "protein_names_refseq": "IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9; interleukin 22 receptor, alpha 1; interleukin-22 receptor subunit alpha-1 precursor; zcytoR11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58985);  (R-HSA-8854691)",
        "pathway_count": 2,
        "publication_count": 61,
        "publication_id_list": "10875937;11035029;11163236;11196675;11390453;11390454;11481447;11564763;11706020;12087100;12351624;12407026;12469119;12941841;14580208;14764663;15120653;15166220;15178681;15308104;15919823;1662392;16750817;16982608;17204547;17828272;17878297;17900301;17906500;18061474;18599299;18669613;18675809;18830264;18941194;19457860;19535621;19664994;20462497;20671117;20966397;21098725;22802649;22962576;25004819;26171402;27133025;28458652;32387766;32897882;32938616;33912179;35051231;35422799;35838587;35970323;37511050;38811550;7512451;7543512;8830676",
        "class_list": "",
        "function": "Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C., [RefSeq, PubMed]; Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis., [RefSeq, PubMed]; Study demonstrated IL-22R1 mRNA and protein expression on nasal epithelial cells; failure of medical and surgical therapy in chronic rhinosinusitis with nasal polyps is associated with significantly decreased expression of IL-22R1, [RefSeq, PubMed]; The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K839;B2R9Y9;Q9HB22",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004904 interferon receptor activity;GO:0042018 interleukin-22 receptor activity;GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0006953 acute-phase response;GO:0050728 negative regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q8N6P7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WX77-1",
        "uniprot_id": [
            {
                "id": "IBPL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WX77",
                "type": "external"
            }
        ],
        "mass": 29005.0,
        "length": 278,
        "protein_name": "Insulin-like growth factor-binding protein-like 1",
        "gene_name": "IGFBPL1",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor-binding protein-like 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001007564",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007564",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGFBPL1; IGFBPRP4",
        "gene_names_refseq": "IGFBP-RP4; IGFBPL1; IGFBPRP4; bA113O24.1",
        "protein_names_uniprotkb": "Insulin-like growth factor-binding protein-like 1; IGFBP-rP4; IGFBP-related protein 10; Insulin-like growth factor-binding-related protein 4",
        "protein_names_refseq": "IGFBP-related protein 10; insulin-like growth factor binding protein related protein 4; insulin-like growth factor-binding protein-like 1 precursor; insulin-like growth factor-binding-related protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347252)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;15845387;17634530;17884839;23090970;23584533;24190977;29391597;29557506;32041673;32488085;32938616;33968037;36010968;36482070;37527036;37938771;38157252",
        "class_list": "",
        "function": "Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of IGFBPL1 correlates with RGC axon growth, and acute knockdown of IGFBPL1 with shRNA or IGFBPL1 knockout in vivo impaired RGC axon growth.  IGFBPL1 binds IGF-1, induces calcium signaling mTOR phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of IGFBPL1 is regulated by aberrant hypermethylation in breast cancer, implying that inactivation of these genes is involved in the pathogenesis of this malignancy., [RefSeq, PubMed]; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein., [UniProtKB, PubMed]; IGFBP-RP4 may be a novel putative tumor suppressor protein., [RefSeq, PubMed]; IGFBPL1 inhibits macrophage lipid accumulation by enhancing the activation of IGR1R/LXRalpha/ABCG1 pathway., [RefSeq, PubMed]; IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy., [RefSeq, PubMed]; Neural precursor cells tune striatal connectivity through the release of IGFBPL1. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that insulin-like growth factor-binding protein-related protein 1 may play a role in decidualization of human endometrial stromal cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0071228 cellular response to tumor cell;GO:0001558 regulation of cell growth;GO:0009966 regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q8WX77-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92819-1",
        "uniprot_id": [
            {
                "id": "HYAS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92819",
                "type": "external"
            }
        ],
        "mass": 63566.0,
        "length": 552,
        "protein_name": "Hyaluronan synthase 2",
        "gene_name": "HAS2",
        "organism": "Human",
        "refseq_name": "hyaluronan synthase 2",
        "refseq_ac": [
            {
                "id": "NP_005319",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005319",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAS2",
        "gene_names_refseq": "HAS2",
        "protein_names_uniprotkb": "Hyaluronan synthase 2; 2.4.1.212; HA synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2",
        "protein_names_refseq": "HA synthase 2; hyaluronan synthase 2; hyaluronate synthase 2; hyaluronic acid synthase 2",
        "tax_id": 9606,
        "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); diabetes insipidus (Disease Ontology:DOID:9409)",
        "pathway": " (hsa:3037);  (R-HSA-2142845)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "10037799;11790779;1426053;14636845;15208308;15642402;1703543;17145755;17540771;18434317;20507985;21228273;22887999;23303191;24134926;24847057;25795779;26992070;28604766;28834231;29557506;29769354;29786170;30379171;30394292;31848261;32157095;32938616;32983136;32993960;33968037;35051231;37231239;37232339;38524634;38734194;38816349;8798477;8798544;8890751;9083017;9601098",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable) (PubMed:20507985, PubMed:21228273, PubMed:23303191, PubMed:32993960). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:20507985, PubMed:21228273, PubMed:8798477). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Downregulation of HAS-2 regulates the chondrocyte cytoskeleton and induces cartilage degeneration by activating the RhoA/ROCK signaling pathway., [RefSeq, PubMed]; Expression of each hyaluronan synthase isoform is regulated differently by growth factors and cytokines in vascular endothelial cells. Expressed in proliferative membranes from proliferative vitreoretinal diseases. May affect progression of diseases., [RefSeq, PubMed]; HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner., [RefSeq, PubMed]; Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix.  It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds.  HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space.  It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate.  HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts.  Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis.  In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.  HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]., [RefSeq]; Hyaluronan synthase expression in prostate adenocarcinoma cells, [RefSeq, PubMed]; MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2., [RefSeq, PubMed]; Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 521,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32MM3",
        "ec_number_list": [
            {
                "id": "2.4.1.212",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0005764 lysosome",
        "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0001570 vasculogenesis;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q92819-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100010000001.110.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q969J5-1",
        "uniprot_id": [
            {
                "id": "I22R2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q969J5",
                "type": "external"
            }
        ],
        "mass": 30550.0,
        "length": 263,
        "protein_name": "Interleukin-22 receptor subunit alpha-2",
        "gene_name": "IL22RA2",
        "organism": "Human",
        "refseq_name": "interleukin-22 receptor subunit alpha-2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_443194",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443194",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL22RA2; PRO19822",
        "gene_names_refseq": "CRF2-10; CRF2-S1; CRF2X; IL-22BP; IL-22R-alpha-2; IL-22RA2; IL22RA2; ZCYTOR16",
        "protein_names_uniprotkb": "Interleukin-22 receptor subunit alpha-2; CRF2-10; CRF2-S1; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2, soluble 1; IL-22 receptor subunit alpha-2; IL-22BP; IL-22R-alpha-2; IL-22RA2; IL22BP; Interleukin-22-binding protein; ZcytoR16",
        "protein_names_refseq": "cytokine receptor class-II member 10; cytokine receptor family type 2, soluble 1; interleukin 22 receptor, alpha 2; interleukin 22-binding protein; interleukin-22 receptor subunit alpha-2 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116379);  (R-HSA-8854691)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10875937;11163236;11196675;11390453;11390454;11481447;11564763;11607789;11706020;12087100;12351624;12469119;12700595;12975309;14580208;14764663;15120653;15166220;15178681;15201862;15340161;15919823;1662392;16750817;16982608;17878297;18599299;18669613;18830264;18941194;19285080;19457860;19535621;20462497;20671117;20966397;21098725;22802649;22962576;25004819;26992070;27133025;28458652;33851257;34920229;36108991;36311796;37975916;7512451;7543512;8830676",
        "class_list": "",
        "function": "Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders., [RefSeq, PubMed]; IL-22BP production is heterogeneously distributed in Crohn's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform 1 may play a role in establishing and maintaining successful pregnancy., [UniProtKB]; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses., [UniProtKB]; Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages., [RefSeq, PubMed]; The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies. Review article, [RefSeq, PubMed]; This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q08AH7;Q6UWM1;Q96A41;Q96QR0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042017 interleukin-22 binding;GO:0042018 interleukin-22 receptor activity;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q969J5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96FT9-1",
        "uniprot_id": [
            {
                "id": "IFT43_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96FT9",
                "type": "external"
            }
        ],
        "mass": 23529.0,
        "length": 208,
        "protein_name": "Intraflagellar transport protein 43 homolog",
        "gene_name": "IFT43",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 43 homolog isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001096034",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096034",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFT43; C14orf179",
        "gene_names_refseq": "C14orf179; CED3; IFT43; RP81; SRTD18",
        "protein_names_uniprotkb": "Intraflagellar transport protein 43 homolog",
        "protein_names_refseq": "IFT complex A subunit; intraflagellar transport 43 homolog; intraflagellar transport protein 43 homolog isoform 2; intraflagellar transport protein 43 homolog",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 81 (Disease Ontology:DOID:0080292); short-rib thoracic dysplasia 18 with polydactyly (Disease Ontology:DOID:0080293); cranioectodermal dysplasia 3 (Disease Ontology:DOID:0080805)",
        "pathway": " (hsa:112752);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10069812;11237011;11285270;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20068231;20435895;20526327;20526328;20530210;20889716;21378380;21427764;21936775;22118932;22361696;22869377;22922713;22992454;23186163;23945166;23990561;24140113;24296415;24596149;24616010;24714562;25205765;25349261;25443296;25576301;25880248;26728094;26740177;27600516;27846572;27932497;28228285;28400947;28514659;28832583;28973684;29220510;29242379;29557506;29789417;30315122;30429286;30779550;31092671;31844290;31848261;32157095;32161166;32357974;32502341;32897882;32938616;32983136;33592498;33691108;33912179;33968037;34932366;35051231;36241641;36284347;37938771;39894887;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380)., [UniProtKB, PubMed, PubMed, PubMed]; C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome., [RefSeq, PubMed]; These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation., [RefSeq, PubMed]; This gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPT6;B4DZI9;G3V385;O95418;Q9ULA9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0005814 centriole;GO:0030991 intraciliary transport particle A",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0035721 intraciliary retrograde transport;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q96FT9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BSH5-1",
        "uniprot_id": [
            {
                "id": "HDHD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BSH5",
                "type": "external"
            }
        ],
        "mass": 28000.0,
        "length": 251,
        "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 3",
        "gene_name": "HDHD3",
        "organism": "Human",
        "refseq_name": "haloacid dehalogenase-like hydrolase domain-containing protein 3",
        "refseq_ac": [
            {
                "id": "NP_001291438",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291438",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HDHD3; C9orf158",
        "gene_names_refseq": "2810435D12Rik; C9orf158; HDHD3",
        "protein_names_uniprotkb": "Haloacid dehalogenase-like hydrolase domain-containing protein 3",
        "protein_names_refseq": "haloacid dehalogenase-like hydrolase domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81932)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "19608861;29317506;31844290;33968037;33981976;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD47",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9BSH5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BX68-1",
        "uniprot_id": [
            {
                "id": "HINT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BX68",
                "type": "external"
            }
        ],
        "mass": 17162.0,
        "length": 163,
        "protein_name": "Adenosine 5'-monophosphoramidase HINT2",
        "gene_name": "HINT2",
        "organism": "Human",
        "refseq_name": "adenosine 5'-monophosphoramidase HINT2 precursor",
        "refseq_ac": [
            {
                "id": "NP_115982",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115982",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HINT2",
        "gene_names_refseq": "HINT2; HIT-17",
        "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT2; 3.9.1.-; HINT-2; HINT-3; HIT-17kDa; Histidine triad nucleotide-binding protein 2, mitochondrial; PKCI-1-related HIT protein",
        "protein_names_refseq": "HINT-2; HINT-3; HIT-17kDa; PKCI-1-related HIT protein; adenosine 5'-monophosphoramidase HINT2 precursor; adenosine 5'-monophosphoramidase HINT2; histidine triad nucleotide-binding protein 2, mitochondrial; protein kinase C inhibitor-2",
        "tax_id": 9606,
        "disease": "Gamstorp-Wohlfart syndrome (Disease Ontology:DOID:0050526)",
        "pathway": " (hsa:84681);  (R-HSA-9013405)",
        "pathway_count": 2,
        "publication_count": 40,
        "publication_id_list": "11784792;12577064;16762638;17064668;17916560;18653718;20877624;22665057;23087206;23096567;23659632;24102721;24715725;25576301;25746724;25880248;27481945;27852748;28228285;28486133;28514659;28649982;28947137;28968488;29776664;30192525;31844290;31871319;31990367;32157095;32357974;32938616;33298915;33968037;34329705;35051231;35154160;36241641;37004779;8945468",
        "class_list": "",
        "function": "Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A. Erratum:[Biochim Biophys Acta Gen Subj. 2022 Feb;1866(2):130035. doi: 10.1016/j.bbagen.2021.130035. PMID: 34687819], [RefSeq, PubMed]; Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638)., [UniProtKB, PubMed, PubMed, PubMed]; Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria., [RefSeq, PubMed]; Histidine triad nucleotide-binding protein 2: From basic science to clinical implications. Review article, [RefSeq, PubMed]; Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A., [RefSeq, PubMed]; Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TCW3",
        "ec_number_list": [
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.4.22.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-",
                "type": "external"
            },
            {
                "id": "3.9.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.29",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29",
                "type": "external"
            },
            {
                "id": "2.7.7.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51",
                "type": "external"
            },
            {
                "id": "3.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0006694 steroid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q9BX68-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYX4-1",
        "uniprot_id": [
            {
                "id": "IFIH1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYX4",
                "type": "external"
            }
        ],
        "mass": 116689.0,
        "length": 1025,
        "protein_name": "Interferon-induced helicase C domain-containing protein 1",
        "gene_name": "IFIH1",
        "organism": "Human",
        "refseq_name": "interferon-induced helicase C domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_071451",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071451",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFIH1; MDA5; RH116",
        "gene_names_refseq": "AGS7; Hlcd; IDDM19; IFIH1; IMD95; MDA-5; MDA5; RLR-2; SGMRT1",
        "protein_names_uniprotkb": "Interferon-induced helicase C domain-containing protein 1; 3.6.4.13; CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140 kDa; Helicard; Helicase with 2 CARD domains; Interferon-induced with helicase C domain protein 1; MDA-5; Melanoma differentiation-associated protein 5; Murabutide down-regulated protein; RIG-I-like receptor 2; RLR-2; RNA helicase-DEAD box protein 116",
        "protein_names_refseq": "CADM-140 autoantigen; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; RIG-I-like receptor 2; RNA helicase-DEAD box protein 116; clinically amyopathic dermatomyositis autoantigen 140 kDa; helicard; helicase with 2 CARD domains; interferon-induced helicase C domain-containing protein 1; melanoma differentiation-associated gene 5; melanoma differentiation-associated protein 5; murabutide down-regulated protein",
        "tax_id": 9606,
        "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); immunodeficiency 95 (Disease Ontology:DOID:0061065); type 1 diabetes mellitus 19 (Disease Ontology:DOID:0110756); Fanconi anemia (Disease Ontology:DOID:13636); systemic lupus erythematosus (Disease Ontology:DOID:9074); Singleton-Merten syndrome 1 (MONDO:MONDO:0024535)",
        "pathway": " (hsa:64135);  (R-HSA-168928);  (R-HSA-5689880);  (R-HSA-5689896);  (R-HSA-918233);  (R-HSA-933541);  (R-HSA-933542);  (R-HSA-933543);  (R-HSA-936440);  (R-HSA-9692916);  (R-HSA-9705671);  (R-HSA-9833109);  (R-HSA-9909505);  (R-HSA-9920588)",
        "pathway_count": 14,
        "publication_count": 382,
        "publication_id_list": "10082512;10385526;10421793;10444327;10581243;10982817;11002417;11073981;11237011;11244049;11463333;11566882;11717445;11805321;11923872;12015121;12019269;12107169;12133833;12221085;12604599;12692549;12759408;12884866;12917689;12917691;14645903;14661020;14703513;15053880;15208624;15258597;15334086;15361868;15563593;15916963;16125763;16127453;16153868;16177806;16214042;16281057;16306936;16394098;16585540;16618810;16699517;16699525;16715065;16846591;16858409;16901786;16914100;16964248;17035307;17190786;17251292;17270291;17290220;17327220;17392790;17412287;17443180;17460044;17526488;17596301;17600090;17709747;17761676;17873522;17980597;17981138;17991829;18057259;18172164;18200010;18307765;18446792;18467330;18496526;18591409;18632802;18636086;18761323;19015242;19017631;19125153;19135894;19188362;19193793;19211564;19363159;19380577;19380580;19383985;19398035;19398555;19403670;19424180;19464428;19479062;19484123;19531363;19565506;19656871;19666475;19668221;19754307;19818707;19838211;19874889;19881509;19893624;19910467;19996094;20015976;20043992;20068231;20096447;20127681;20228808;20304918;20368735;20403326;20434986;20501646;20553488;20627800;20628368;20950133;21156324;21217758;21239494;21245900;21362556;21566123;21571647;21596315;21616437;21632562;21659512;21742966;21791617;21849505;21884169;21962518;22029577;22046132;22085928;22124327;22128162;22160685;22216260;22253733;22301138;22312431;22383950;22619329;22941947;23159851;23395819;23453971;23481700;23483519;23486064;23499489;23711367;23783831;23824326;23825189;23827681;24056413;24173023;24260525;24390337;24493797;24509444;24610782;24622840;24686847;24714562;24715725;24722368;24755855;24854014;24896179;24995871;25135833;25197364;25228397;25305019;25418920;25505266;25576301;25578727;25620204;25645385;25764917;25802875;25865883;25880248;25892735;25904330;25907116;26101251;26154972;26280536;26320399;26375851;26378163;26992070;27164085;27203180;27312109;27482829;27600516;27832191;27846572;27862975;27920218;28063628;28148787;28218747;28228285;28446606;28514659;28594402;28606988;28649982;28764923;28832583;28834231;28855257;28904123;29018476;29117565;29242379;29294448;29331515;29371260;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;29789417;30169894;30185776;30193849;30224801;30312637;30315122;30410026;30429286;30484775;30550790;30558248;30779550;30833945;31034780;31092671;31154438;31217245;31231549;31434731;31455651;31530632;31844290;31848261;31850239;31867016;31937595;31998317;32152943;32157095;32161166;32169843;32265295;32350084;32353859;32357974;32387766;32428392;32432721;32488085;32502341;32589897;32726803;32728199;32778820;32897882;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33140045;33141586;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33537174;33567255;33592498;33633747;33691108;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34021074;34054808;34084167;34087483;34110168;34166398;34185709;34211107;34239064;34290717;34341353;34357683;34375313;34400613;34405274;34439781;34452305;34471099;34502139;34509645;34561969;34597346;34932366;35051231;35102342;35318648;35580925;35643212;36215666;36284347;36581221;36793726;37051252;37938771;38733267;38843304;38964834;38985764;39313944;7578059;9008162;9463386;9541017;9660935;9689078;9822609;9989503",
        "class_list": "",
        "function": "IBR1, a novel endogenous IFIH1-binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS., [RefSeq, PubMed]; IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus., [RefSeq, PubMed]; IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]., [RefSeq]; IFIH1 variants are associated with generalised epilepsy preceded by febrile seizures. Publication Status: Online-Only, [RefSeq, PubMed]; Identifying the association between polymorphisms in the GZMB and IFIH1 genes and psoriasis in Egyptians., [RefSeq, PubMed]; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties, [RefSeq, PubMed]; Temporal regulation of MDA5 inactivation by Caspase-3 dependent cleavage of 14-3-3eta. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2NKL6;Q6DC96;Q86X56;Q96MX8;Q9H3G6",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "6.3.2.n3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3",
                "type": "external"
            },
            {
                "id": "3.4.22.61",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.4.22.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.63",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "3.4.26.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0060760 positive regulation of response to cytokine stimulus;GO:0016925 protein sumoylation;GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 38.3,
        "record_id": "Q9BYX4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H7X7-1",
        "uniprot_id": [
            {
                "id": "IFT22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H7X7",
                "type": "external"
            }
        ],
        "mass": 20835.0,
        "length": 185,
        "protein_name": "Intraflagellar transport protein 22 homolog",
        "gene_name": "IFT22",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 22 homolog isoform b",
        "refseq_ac": [
            {
                "id": "NP_001124292",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124292",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFT22; RABL5",
        "gene_names_refseq": "CFAP9; FAP9; IFT22; RABL5",
        "protein_names_uniprotkb": "Intraflagellar transport protein 22 homolog; Rab-like protein 5",
        "protein_names_refseq": "RAB, member RAS oncogene family-like 5; RAB, member of RAS oncogene family-like 5; intraflagellar transport 22 homolog; intraflagellar transport protein 22 homolog isoform b; intraflagellar transport protein 22 homolog; rab-like protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64792);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "10069812;11237011;11285270;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22922713;22992454;23186163;23945166;23990561;24140113;24296415;24596149;24616010;24715725;25205765;25349261;25443296;25576301;27920218;28832583;30315122;31844290;32157095;32161166;32897882;32938616;33298915;33691108;33981976;34087483;34357683;34405274;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Small GTPase-like component of the intraflagellar transport (IFT) complex B., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49AG1;Q69YV5;Q9BSW4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0012505 endomembrane system;GO:0030991 intraciliary transport particle A;GO:0030992 intraciliary transport particle B",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0060271 cilium assembly;GO:0035720 intraciliary anterograde transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9H7X7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQ87-1",
        "uniprot_id": [
            {
                "id": "HEYL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQ87",
                "type": "external"
            }
        ],
        "mass": 35087.0,
        "length": 328,
        "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein",
        "gene_name": "HEYL",
        "organism": "Human",
        "refseq_name": "hairy/enhancer-of-split related with YRPW motif-like protein",
        "refseq_ac": [
            {
                "id": "NP_055386",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055386",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEYL; BHLHB33; HRT3",
        "gene_names_refseq": "HESR3; HEY3; HEYL; HRT3; bHLHb33",
        "protein_names_uniprotkb": "Hairy/enhancer-of-split related with YRPW motif-like protein; Class B basic helix-loop-helix protein 33; HRT-3; Hairy-related transcription factor 3; bHLHb33; hHRT3; hHeyL",
        "protein_names_refseq": "HEY-like protein; HRT-3; class B basic helix-loop-helix protein 33; hHRT3; hHeyL; hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related with YRPW motif-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26508);  (R-HSA-2122947);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-9013508);  (R-HSA-9762293)",
        "pathway_count": 6,
        "publication_count": 87,
        "publication_id_list": "10206645;10713164;10860664;10879540;10882063;10964718;11006133;11044625;11095750;11461910;11585921;11740940;11866432;12050117;12209127;12354787;12386158;12391150;12530964;14980219;15107403;15485867;15546612;15574878;15699330;15760269;15824097;15829515;16093323;16256737;16530044;16738328;16793922;17003037;17114293;17401372;17646408;17646409;18043734;18077452;18094723;18296446;18374649;18824583;18824585;18974129;19151708;19524514;19726682;20972443;22227038;22396495;24130169;24810778;25417103;25576301;27749937;27841855;29269046;29296180;29557506;29642003;30429286;31848261;32463580;33592498;33981976;34831437;35580925;35655915;36284347;36854682;37024320;37938771;7566092;7588063;8001118;8649374;8687460;9244301;9315665;9462510;9604939;9620803;9651681;9694793;9819428",
        "class_list": "",
        "function": "Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6., [UniProtKB, PubMed]; Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay., [RefSeq, PubMed]; Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Partial-Methylated HeyL Promoter Predicts the Severe Illness in Egyptian COVID-19 Patients. Publication Status: Online-Only, [RefSeq, PubMed]; The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TG99",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0003208 cardiac ventricle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045666 positive regulation of neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9NQ87-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQE9-1",
        "uniprot_id": [
            {
                "id": "HINT3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQE9",
                "type": "external"
            }
        ],
        "mass": 20361.0,
        "length": 182,
        "protein_name": "Adenosine 5'-monophosphoramidase HINT3",
        "gene_name": "HINT3",
        "organism": "Human",
        "refseq_name": "adenosine 5'-monophosphoramidase HINT3",
        "refseq_ac": [
            {
                "id": "NP_612638",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612638",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HINT3",
        "gene_names_refseq": "HINT3; HINT4",
        "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT3; 3.9.1.-; HINT-3; Histidine triad nucleotide-binding protein 3",
        "protein_names_refseq": "HINT-3; HIT-like protein; adenosine 5'-monophosphoramidase HINT3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:135114)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "12119013;17870088;18669648;19531498;23301498;25576301;26992070;29485866;29493099;30429286;31844290;34087483;34357683;35580925;37203409",
        "class_list": "",
        "function": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088)., [UniProtKB, PubMed]; HINT3 suppresses AKT/mTOR signaling pathway activity during breast cancer tumorigenesis through PTEN transcriptional activation., [RefSeq, PubMed]; Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]., [RefSeq]; Results show that significant differences in phosphoramidase activity, oligomeric state, and cellular localization suggest that Hint3s should be placed in a distinct branch of the histidine triad superfamily., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQ91;Q8N0Y9",
        "ec_number_list": [
            {
                "id": "3.4.22.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-",
                "type": "external"
            },
            {
                "id": "3.9.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.29",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29",
                "type": "external"
            },
            {
                "id": "2.7.7.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51",
                "type": "external"
            },
            {
                "id": "3.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9NQE9-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZ38-1",
        "uniprot_id": [
            {
                "id": "IDAS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZ38",
                "type": "external"
            }
        ],
        "mass": 21312.0,
        "length": 188,
        "protein_name": "Uncharacterized protein IDI2-AS1",
        "gene_name": "IDI2-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IDI2-AS1; C10orf110; HT009",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein IDI2-AS1; IDI2 antisense RNA 1; IDI2 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "10931946;24715725",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q9NZ38-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y241-1",
        "uniprot_id": [
            {
                "id": "HIG1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y241",
                "type": "external"
            }
        ],
        "mass": 10143.0,
        "length": 93,
        "protein_name": "HIG1 domain family member 1A, mitochondrial",
        "gene_name": "HIGD1A",
        "organism": "Human",
        "refseq_name": "HIG1 domain family member 1A, mitochondrial isoform a",
        "refseq_ac": [
            {
                "id": "NP_001093138",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093138",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HIGD1A; HIG1; HSPC010",
        "gene_names_refseq": "HIG1; HIGD1A; RCF1a",
        "protein_names_uniprotkb": "HIG1 domain family member 1A, mitochondrial; Hypoxia-inducible gene 1 protein; RCF1 homolog A; RCF1a",
        "protein_names_refseq": "HIG1 domain family member 1A, mitochondrial isoform a; HIG1 domain family member 1A, mitochondrial; HIG1 domain family, member 1A; RCF1 homolog A; hypoxia inducible gene 1; hypoxia-inducible gene 1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25994);  (R-HSA-1234158);  (R-HSA-9864848)",
        "pathway_count": 3,
        "publication_count": 97,
        "publication_id_list": "10202154;10690527;11063749;11156414;11230166;11237011;11959977;11959990;14668441;15184875;17804822;18187047;19503089;19788888;20877624;21479871;22342701;22609626;23125284;23260140;23345593;23746447;24403053;24613356;24714562;25576301;25683712;25926683;25959673;26154972;26160453;26321642;26375851;26728094;26992070;27452731;27693358;27893789;27920218;28082314;28199844;28228285;28330871;28446606;28832583;28834231;29154948;29508533;29557506;29632711;29789417;30315122;30379171;31154438;31530632;31536960;31844290;32157095;32317297;32375044;32488085;32502341;32938616;32983136;33043033;33141586;33592498;33691108;33717175;33968037;33981976;34357683;34969438;35051231;35580925;35750769;36010968;36241641;36284347;36804467;37086631;37185850;37938771;38053282;7539918;7836384;8387214;8663540;8756616;8917528;9000051;9027736;9079689;9632793;9822602;9840812;9843204",
        "class_list": "",
        "function": "HIG1 domain family member 1A is a crucial regulator of disorders associated with hypoxia. Review article, [RefSeq, PubMed]; HIGD1A inactivated by DNA hypermethylation promotes invasion of kidney renal clear cell carcinoma., [RefSeq, PubMed]; Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-kappaB-NR2F1 nexus., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes., [UniProtKB, PubMed]; The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UFZ2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0032991 protein-containing complex;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0022904 respiratory electron transport chain;GO:0097250 mitochondrial respirasome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "Q9Y241-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6W8-1",
        "uniprot_id": [
            {
                "id": "ICOS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6W8",
                "type": "external"
            }
        ],
        "mass": 22625.0,
        "length": 199,
        "protein_name": "Inducible T-cell costimulator",
        "gene_name": "ICOS",
        "organism": "Human",
        "refseq_name": "inducible T-cell costimulator precursor",
        "refseq_ac": [
            {
                "id": "NP_036224",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036224",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICOS; AILIM",
        "gene_names_refseq": "AILIM; CD278; CVID1; ICOS",
        "protein_names_uniprotkb": "Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule",
        "protein_names_refseq": "activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator; inducible T-cell costimulator precursor; inducible costimulator",
        "tax_id": 9606,
        "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); colitis (Disease Ontology:DOID:0060180); common variable immunodeficiency 1 (Disease Ontology:DOID:0081144); celiac disease (Disease Ontology:DOID:10608); common variable immunodeficiency (Disease Ontology:DOID:12177); uveitis (Disease Ontology:DOID:13141); myocarditis (Disease Ontology:DOID:820)",
        "pathway": " (hsa:29851);  (R-HSA-9725371)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "10779774;11006126;11169414;11735222;11751994;12577056;12748172;12753665;16009132;17110082;17111047;17416736;17690253;17922009;18024471;18097461;19931508;20015877;20493732;21715655;22955283;24060861;25818168;27135603;27553022;28832583;29242379;29588546;29786170;30523347;30692217;31154438;31217245;31366041;31390744;31434245;32983136;33033255;38459032;38506253;38616999;38845009;39113896;9930702",
        "class_list": "",
        "function": "ICOS-ICOSL pathway enhances NKT-like cell antiviral function in pregnant women with COVID-19. Publication Status: Online-Only, [RefSeq, PubMed]; Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS). Publication Status: Online-Only, [RefSeq, PubMed]; Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:9930702). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed:33033255). Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed:27135603). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed:30523347). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The Expression and Prognostic Significance of ICOS in NSCLC Integrated Pan-Cancer and Multi-Omics Analyses. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional profile and immune infiltration in colorectal cancer reveal the significance of inducible T-cell costimulator as a crucial immune checkpoint molecule., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N6W8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0031295 T cell costimulation;GO:0098609 cell-cell adhesion;GO:0002517 T cell tolerance induction;GO:0061470 T follicular helper cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q9Y6W8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZNG9-1",
        "uniprot_id": [
            {
                "id": "KRBD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZNG9",
                "type": "external"
            }
        ],
        "mass": 56205.0,
        "length": 492,
        "protein_name": "KRAB domain-containing protein 2",
        "gene_name": "KRABD2",
        "organism": "Human",
        "refseq_name": "KRAB domain-containing protein 2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001291876",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291876",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRABD2; KRBA2",
        "gene_names_refseq": "KRABD2; KRBA2",
        "protein_names_uniprotkb": "KRAB domain-containing protein 2",
        "protein_names_refseq": "KRAB domain-containing protein 2 isoform b; KRAB domain-containing protein 2; KRAB-A domain containing 2; KRAB-A domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:124751)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;17525332;18669648;32157095;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IYY0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003676 nucleic acid binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0015074 DNA integration",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q6ZNG9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B7U540-1",
        "uniprot_id": [
            {
                "id": "KCJ18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B7U540",
                "type": "external"
            }
        ],
        "mass": 48880.0,
        "length": 433,
        "protein_name": "Inward rectifier potassium channel 18",
        "gene_name": "KCNJ18",
        "organism": "Human",
        "refseq_name": "inward rectifier potassium channel 18",
        "refseq_ac": [
            {
                "id": "NP_001181887",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181887",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNJ18",
        "gene_names_refseq": "KCNJ18; KIR2.6; TTPP2",
        "protein_names_uniprotkb": "Inward rectifier potassium channel 18; Inward rectifier K(+) channel Kir2.6; Potassium channel, inwardly rectifying subfamily J member 18",
        "protein_names_refseq": "inward rectifier K(+) channel Kir2.6; inward rectifier potassium channel 18; inwardly rectifying potassium channel 18; potassium channel, inwardly rectifying subfamily J, member 18; potassium voltage-gated channel subfamily J member 18; thyrotoxic periodic paralysis susceptibility ion channel",
        "tax_id": 9606,
        "disease": "EAST syndrome (Disease Ontology:DOID:0060484); thyrotoxic periodic paralysis, susceptibility to, 2 (MONDO:MONDO:0013193)",
        "pathway": " (hsa:100134444)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "20074522;21209095;21665951;22910584;25885757;27008341;27178871;31361309;31844290;35051231",
        "class_list": "",
        "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium., [UniProtKB, PubMed, PubMed]; Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels., [RefSeq, PubMed]; Single-nucleotide variant in KCNJ18 gene is associated with Thyrotoxic Periodic Paralysis., [RefSeq, PubMed]; Suggest that decreased outward K(+) current from hypofunction of Kir2.6 predisposes the sarcolemma to hypokalemia-induced paradoxical depolarization during attacks, which in turn leads to Na(+) channel inactivation and inexcitability of muscles Erratum:[J Biol Chem. 2011 Sep 23;286(38):33707], [RefSeq, PubMed]; TPP and SPP have the same susceptible gene variant rs623011 and may share the pathogenic mechanism of reduced Kir current in skeletal muscle independent of thyroid hormone., [RefSeq, PubMed]; This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]., [RefSeq]; While sequencing candidate genes, we identified a previously unreported gene (not present in human sequence databases) that encodes an inwardly rectifying potassium (Kir) channel, Kir2.6., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A075B742;A0A142CKZ1;A0A142CKZ2",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex",
        "go_biological_process": "GO:1990573 potassium ion import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "B7U540-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6JEL2-1",
        "uniprot_id": [
            {
                "id": "KLH10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6JEL2",
                "type": "external"
            }
        ],
        "mass": 68942.0,
        "length": 608,
        "protein_name": "Kelch-like protein 10",
        "gene_name": "KLHL10",
        "organism": "Human",
        "refseq_name": "kelch-like protein 10 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001316524",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316524",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KLHL10",
        "gene_names_refseq": "KLHL10; SPGF11",
        "protein_names_uniprotkb": "Kelch-like protein 10",
        "protein_names_refseq": "kelch-like protein 10 isoform 1; kelch-like protein 10; testicular tissue protein Li 104",
        "tax_id": 9606,
        "disease": "spermatogenic failure 11 (Disease Ontology:DOID:0070180)",
        "pathway": " (hsa:317719)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;15136734;17047026;20218307;35051231;36010968",
        "class_list": "",
        "function": "May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis., [UniProtKB]; The KLHL-10 gene is not a major contributor to azoospermia, oligospermia or asthenospermia in Chinese population. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NW28;Q96MC0",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6JEL2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13797-1",
        "uniprot_id": [
            {
                "id": "ITA9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13797",
                "type": "external"
            }
        ],
        "mass": 114489.0,
        "length": 1035,
        "protein_name": "Integrin alpha-9",
        "gene_name": "ITGA9",
        "organism": "Human",
        "refseq_name": "integrin alpha-9 precursor",
        "refseq_ac": [
            {
                "id": "NP_002198",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002198",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ITGA9",
        "gene_names_refseq": "ALPHA-RLC; ITGA4L; ITGA9; RLC",
        "protein_names_uniprotkb": "Integrin alpha-9; Integrin alpha-RLC",
        "protein_names_refseq": "integrin alpha-9 precursor; integrin alpha-9; integrin alpha-RLC",
        "tax_id": 9606,
        "disease": "congenital chylothorax (Disease Ontology:DOID:0060646); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); pancreatic cancer (Disease Ontology:DOID:1793); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:3680);  (R-HSA-216083);  (R-HSA-3000178);  (R-HSA-445144)",
        "pathway_count": 4,
        "publication_count": 141,
        "publication_id_list": "10.1101/2023.09.13.557529;10022829;10209034;10339611;10366422;10438935;10543983;10593924;10605720;10611478;10640428;10673326;10673366;10713152;10811134;10818153;10982388;11084047;11158588;11237011;11259413;11518510;11572855;11713259;11980922;12225811;12456642;12496264;12585966;12682293;12807887;1376317;14715956;14718570;15075323;15240572;15296743;15330449;15345499;15383545;1544908;15597056;15713743;1588291;15899827;16002701;16051604;16239428;16293224;16493581;16731529;16754661;16933105;16959974;17253643;17322306;17339034;17588949;17968485;18222703;18555990;18710925;18775695;19159218;19502598;20033473;2010551;2059554;20705068;21642437;21789315;22134916;22177953;22539938;22654117;22884367;2295682;23374253;2364322;23954936;2412224;2420006;2430969;25576301;25892735;27600516;29393594;29557506;29769354;30429286;30573663;32157095;32161166;32387766;32983136;35051231;35494241;35802072;36221013;37074911;38279497;39002785;39382510;6193777;6439184;7499434;7505120;7525578;7527058;7541634;7542249;7542669;7559467;7685013;7693733;7852349;8002934;8118028;8245132;8290272;8344274;8388392;8440685;8509458;8560266;8592152;8798654;8838667;8910476;8943283;9251239;9252349;9294172;9341124;9346959;9396761;9443892;9565552;9685393;9858236;9949188",
        "class_list": "",
        "function": "Alpha9beta1 integrin & its ligands as new potential biomarkers in FMF., [RefSeq, PubMed]; ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072)., [UniProtKB, UniProtKB, PubMed]; Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin-alpha9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia., [RefSeq, PubMed]; This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 6,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14638",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0098640 integrin binding involved in cell-matrix adhesion;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009925 basal plasma membrane;GO:0034679 integrin alpha9-beta1 complex;GO:0008305 integrin complex",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0098609 cell-cell adhesion;GO:0045906 negative regulation of vasoconstriction",
        "synthesized_glycan_count": 0,
        "hit_score": 15.2,
        "record_id": "Q13797-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NAB2-1",
        "uniprot_id": [
            {
                "id": "KBTB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NAB2",
                "type": "external"
            }
        ],
        "mass": 69839.0,
        "length": 612,
        "protein_name": "Kelch repeat and BTB domain-containing protein 3",
        "gene_name": "KBTBD3",
        "organism": "Human",
        "refseq_name": "kelch repeat and BTB domain-containing protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_689646",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689646",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KBTBD3; BKLHD3",
        "gene_names_refseq": "BKLHD3; KBTBD3",
        "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 3; BTB and kelch domain-containing protein 3",
        "protein_names_refseq": "BTB and kelch domain containing 3; BTB and kelch domain-containing protein 3; epididymis secretory sperm binding protein; kelch repeat and BTB (POZ) domain containing 3; kelch repeat and BTB domain-containing protein 3 isoform 1; kelch repeat and BTB domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:143879)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;20353815;30379171;31530632;32357974;32387766;33968037",
        "class_list": "",
        "function": "Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated Kelch domain containing 3 in 20 healthy individuals., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6N066;Q86X38;Q96NK5",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NAB2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15842-1",
        "uniprot_id": [
            {
                "id": "KCNJ8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15842",
                "type": "external"
            }
        ],
        "mass": 47968.0,
        "length": 424,
        "protein_name": "ATP-sensitive inward rectifier potassium channel 8",
        "gene_name": "KCNJ8",
        "organism": "Human",
        "refseq_name": "ATP-sensitive inward rectifier potassium channel 8",
        "refseq_ac": [
            {
                "id": "NP_004973",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004973",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNJ8",
        "gene_names_refseq": "KCNJ8; KIR6.1; uKATP-1",
        "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1",
        "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 8; inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium voltage-gated channel subfamily J member 8",
        "tax_id": 9606,
        "disease": "hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); coronary artery disease (Disease Ontology:DOID:3393); sudden infant death syndrome (Disease Ontology:DOID:9007)",
        "pathway": " (hsa:3764);  (R-HSA-1296025)",
        "pathway_count": 2,
        "publication_count": 23,
        "publication_id_list": "11237011;12200636;15087422;17081983;18258787;20153265;20558321;21836131;24176758;24700710;28842488;29393594;29557506;31154438;31844290;32157095;32215968;33633747;33846486;34711681;36010968;8595887;9573340",
        "class_list": "",
        "function": "A novel mutation in the KCNJ8 gene encoding the Kir6.1 subunit of an ATP-sensitive potassium channel in a Japanese patient with Cantu syndrome. Erratum:[J Eur Acad Dermatol Venereol. 2021 Jan;35(1):263. doi: 10.1111/jdv.17015. PMID: 33617015], [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]., [RefSeq]; The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00657",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0005524 ATP binding;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0005242 inward rectifier potassium channel activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0008282 inward rectifying potassium channel",
        "go_biological_process": "GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0055085 transmembrane transport;GO:0001822 kidney development;GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q15842-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NXV2-1",
        "uniprot_id": [
            {
                "id": "KCTD5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NXV2",
                "type": "external"
            }
        ],
        "mass": 26093.0,
        "length": 234,
        "protein_name": "BTB/POZ domain-containing protein KCTD5",
        "gene_name": "KCTD5",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein KCTD5",
        "refseq_ac": [
            {
                "id": "NP_061865",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061865",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCTD5",
        "gene_names_refseq": "KCTD5",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD5",
        "protein_names_refseq": "BTB/POZ domain-containing protein KCTD5; potassium channel tetramerisation domain containing 5",
        "tax_id": 9606,
        "disease": "myoclonic dystonia (Disease Ontology:DOID:0090033)",
        "pathway": " (hsa:54442)",
        "pathway_count": 1,
        "publication_count": 46,
        "publication_id_list": "11237011;17239418;18491316;18573101;19361449;20068231;23186163;25576301;28218747;28411811;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29769354;29786170;30315122;30410026;30779550;30833945;31154438;31217245;31530632;31844290;32157095;32161166;32357974;32897882;32938616;32983136;33053687;33592498;33633747;33912179;33981976;34561969;34934014;35051231;35561310;35580925;36284347;38732215;40914422",
        "class_list": "",
        "function": "Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. Findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases, [RefSeq, PubMed]; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449)., [UniProtKB, PubMed, PubMed]; K(+) Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca(2+) Signaling and Rac1 Activity. Publication Status: Online-Only, [RefSeq, PubMed]; KCTD Proteins Have Redundant Functions in Controlling Cellular Growth. Publication Status: Online-Only, [RefSeq, PubMed]; Members of the KCTD family are major regulators of cAMP signaling., [RefSeq, PubMed]; Structure reveals assemblies of five subunits while tetramers were anticipated; pentameric stoichiometry is observed also in solution by scanning transmission electron microscopy mass analysis and analytical ultracentrifugation, [RefSeq, PubMed]; We have identified a novel cellular AAV-2 Rep78/Rep68 interaction partner, KCTD5, located predominantly in the cytoplasm., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DU96",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097602 cullin family protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q9NXV2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14649-1",
        "uniprot_id": [
            {
                "id": "KCNK3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14649",
                "type": "external"
            }
        ],
        "mass": 43518.0,
        "length": 394,
        "protein_name": "Potassium channel subfamily K member 3",
        "gene_name": "KCNK3",
        "organism": "Human",
        "refseq_name": "potassium channel subfamily K member 3",
        "refseq_ac": [
            {
                "id": "NP_002237",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002237",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNK3; TASK1; TASK",
        "gene_names_refseq": "DDSA; K2p3.1; KCNK3; OAT1; PPH4; TASK-1; TASK1; TASK; TBAK1",
        "protein_names_uniprotkb": "Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1",
        "protein_names_refseq": "TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ 1; TWIK-related acid-sensitive K+ channel; acid-sensitive potassium channel protein TASK-1; acid-sensitive potassium channel protein TASK; cardiac potassium channel; potassium channel subfamily K member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; two P domain potassium channel; two pore K(+) channel KT3.1; two pore potassium channel KT3.1",
        "tax_id": 9606,
        "disease": "developmental delay with sleep apnea (Disease Ontology:DOID:0070717); primary pulmonary hypertension (Disease Ontology:DOID:14557); status epilepticus (Disease Ontology:DOID:1824); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:3777);  (R-HSA-1299316);  (R-HSA-5576886)",
        "pathway_count": 3,
        "publication_count": 28,
        "publication_id_list": "10321245;10748056;11680614;15795311;16382106;17652773;18824070;20393194;21357689;21838752;22948150;23169818;23883380;25576301;26919430;29557506;32157095;32499642;32938616;35051231;35580925;36016502;36195757;36241641;37793594;38841840;39215006;9312005",
        "class_list": "",
        "function": "Activation of neurokinin-III receptors modulates human atrial TASK-1 currents., [RefSeq, PubMed]; Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells., [RefSeq, PubMed]; Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea., [RefSeq, PubMed]; Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension., [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:23169818, PubMed:26919430, PubMed:32499642, PubMed:36195757, PubMed:9312005). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (PubMed:22948150). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:23169818, PubMed:32499642). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (By similarity). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 56,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53SU2",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0005216 monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse",
        "go_biological_process": "GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0071456 cellular response to hypoxia;GO:0006813 potassium ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O14649-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95279-1",
        "uniprot_id": [
            {
                "id": "KCNK5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95279",
                "type": "external"
            }
        ],
        "mass": 55130.0,
        "length": 499,
        "protein_name": "Potassium channel subfamily K member 5",
        "gene_name": "KCNK5",
        "organism": "Human",
        "refseq_name": "potassium channel subfamily K member 5",
        "refseq_ac": [
            {
                "id": "NP_003731",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003731",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNK5; TASK2",
        "gene_names_refseq": "K2p5.1; KCNK5b; KCNK5; TASK-2; TASK2",
        "protein_names_uniprotkb": "Potassium channel subfamily K member 5; Acid-sensitive potassium channel protein TASK-2; TWIK-related acid-sensitive K(+) channel 2",
        "protein_names_refseq": "K2P5.1 potassium channel; TWIK-related acid-sensitive K(+) channel 2; TWIK-related acid-sensitive K+ 2; TWIK-related acid-sensitive K+ channel 2; acid-sensitive potassium channel protein TASK-2; potassium channel subfamily K member 5; potassium channel, subfamily K, member 1 (TASK-2); potassium channel, subfamily, member 5 (KCNK5); potassium channel, two pore domain subfamily K, member 5",
        "tax_id": 9606,
        "disease": "heart conduction disease (Disease Ontology:DOID:10273)",
        "pathway": " (hsa:8645);  (R-HSA-5576886)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "12634929;15795311;16382106;17652773;18516069;18691976;20393194;26919430;28228285;29242379;29293917;30429286;31092671;31217245;31844290;31848261;31998317;32350084;32357974;33762637;34185709;34211107;34357683;35251023;36063992;37217939;38236186;9812978",
        "class_list": "",
        "function": "Common variants in KCNK5 and FHL5 genes contributed to the susceptibility of migraine without aura in Han Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992)., [UniProtKB, PubMed, PubMed, PubMed]; KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye., [RefSeq, PubMed]; Mutations in the promoter region of the TWIK-related acid-sensitive K(+) channel 2 (TASK-2) gene did not result in hypertension or primary aldosteronism (PA) during long-term follow-up in healthy participants thus they do not seem to be a factor in causing PA by themselves., [RefSeq, PubMed]; TASK-2 does not possess a histidine residue at homologous position. Inclusion of such a residue failed to produce expected increase in pH sensitivity; instead, a slight decrease was observed, [RefSeq, PubMed]; This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAQ6;B5TJL2;Q5VV76",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0005267 potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex",
        "go_biological_process": "GO:0006813 potassium ion transport;GO:0060075 regulation of resting membrane potential;GO:0071805 potassium ion transmembrane transport;GO:0097623 potassium ion export across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "O95279-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C5Y4-1",
        "uniprot_id": [
            {
                "id": "KRA14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C5Y4",
                "type": "external"
            }
        ],
        "mass": 12324.0,
        "length": 121,
        "protein_name": "Keratin-associated protein 1-4",
        "gene_name": "KRTAP1-4",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 1-4",
        "refseq_ac": [
            {
                "id": "NP_001244234",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001244234",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRTAP1-4; KAP1.4; KRTAP1.4",
        "gene_names_refseq": "KAP1.4; KRTAP1-4; KRTAP1.4",
        "protein_names_uniprotkb": "Keratin-associated protein 1-4; High sulfur keratin-associated protein 1.4; Keratin-associated protein 1.4",
        "protein_names_refseq": "high sulfur keratin-associated protein 1.4; keratin-associated protein 1-4; keratin-associated protein 1.4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728255);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "11279113;12228244;15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; No polymorphic alleles were found for the hKAP1.4 and hKAP1.5 genes in Japanese and Caucasian individuals, [RefSeq, PubMed]; The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]).[supplied by OMIM, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJ92",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P0C5Y4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30085-1",
        "uniprot_id": [
            {
                "id": "KCY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30085",
                "type": "external"
            }
        ],
        "mass": 22222.0,
        "length": 196,
        "protein_name": "UMP-CMP kinase",
        "gene_name": "CMPK1",
        "organism": "Human",
        "refseq_name": "UMP-CMP kinase isoform b",
        "refseq_ac": [
            {
                "id": "NP_001129612",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129612",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CMPK1; CMK; CMPK; UCK; UMK; UMPK",
        "gene_names_refseq": "CK; CMK; CMPK1; CMPK; UMK; UMP-CMPK; UMPK",
        "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase",
        "protein_names_refseq": "UMP-CMP kinase isoform b; UMP/CMP kinase; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; cytidylate kinase; dCMP kinase; deoxycytidylate kinase; nucleoside-diphosphate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:51727);  (R-HSA-499943)",
        "pathway_count": 2,
        "publication_count": 106,
        "publication_id_list": "10215863;10453732;10462544;10618642;10716435;10799505;10884394;10899599;10931946;11237011;11277919;11278511;11517226;11681623;11796141;11912132;1286669;12972261;13211603;14729598;15163660;15630091;16179339;16373698;16756507;16820675;17320107;177353;17824959;18469;1851158;18635542;18997010;19176520;19220460;19608861;19766732;21080915;211388;211390;22847445;23301498;23416111;23481700;24275569;25418920;2542324;25880248;26375851;2656695;2668278;27397612;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29789417;30192525;30315122;30410026;31844290;32157095;32350084;32357974;32488085;32938616;32983136;33214551;33465208;33592498;33912179;33936100;33968037;33981976;34019948;35051231;35154160;35251023;35580925;36010968;36241641;36284347;37258394;40596516;40615;5484814;6182143;6248551;7685356;7851394;8313870;8448179;8663313;9488696;9677297",
        "class_list": "",
        "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]., [RefSeq]; Twenty-Four Percent of Wildland Firefighters Reach Critical Levels of Serum Creatine Kinase During 80-Hour Critical Training., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6S5;B4DPU7;E9PGI8;Q53GB7;Q5SVZ0;Q96C07;Q9UBQ8;Q9UIA2",
        "ec_number_list": [
            {
                "id": "2.7.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            },
            {
                "id": "2.7.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.4.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0050145 nucleoside monophosphate kinase activity;GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0015949 nucleobase-containing small molecule interconversion;GO:0009220 pyrimidine ribonucleotide biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "P30085-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48050-1",
        "uniprot_id": [
            {
                "id": "KCNJ4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48050",
                "type": "external"
            }
        ],
        "mass": 49500.0,
        "length": 445,
        "protein_name": "Inward rectifier potassium channel 4",
        "gene_name": "KCNJ4",
        "organism": "Human",
        "refseq_name": "inward rectifier potassium channel 4",
        "refseq_ac": [
            {
                "id": "NP_004972",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004972",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNJ4; IRK3",
        "gene_names_refseq": "HIRK2; HIR; HRK1; IRK-3; IRK3; KCNJ4; Kir2.3",
        "protein_names_uniprotkb": "Inward rectifier potassium channel 4; HIRK2; HIR; HRK1; Hippocampal inward rectifier; IRK-3; Inward rectifier K(+) channel Kir2.3; Potassium channel, inwardly rectifying subfamily J member 4",
        "protein_names_refseq": "hippocampal inward rectifier potassium channel; inward rectifier K(+) channel Kir2.3; inward rectifier potassium channel 4; potassium channel, inwardly rectifying subfamily J, member 4; potassium voltage-gated channel subfamily J member 4",
        "tax_id": 9606,
        "disease": "EAST syndrome (Disease Ontology:DOID:0060484)",
        "pathway": " (hsa:3761);  (R-HSA-1296041);  (R-HSA-1296053);  (R-HSA-5576886);  (R-HSA-997272)",
        "pathway_count": 5,
        "publication_count": 19,
        "publication_id_list": "12032359;15795311;16382106;17185339;17652773;19635485;20393194;20453851;20655490;30192525;30512237;31844290;32350084;35051231;35251023;7576658;8016146;8034048;8051145",
        "class_list": "",
        "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results shed some light on the contribution of KCNJ4 functioning as a significant player in LADC, implying that KCNJ4 might be a valuable prognostic biomarker and a potential therapeutic target for LADC treatment, [RefSeq, PubMed]; Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14D44",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005242 inward rectifier potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045211 postsynaptic membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "P48050-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48544-1",
        "uniprot_id": [
            {
                "id": "KCNJ5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48544",
                "type": "external"
            }
        ],
        "mass": 47668.0,
        "length": 419,
        "protein_name": "G protein-activated inward rectifier potassium channel 4",
        "gene_name": "KCNJ5",
        "organism": "Human",
        "refseq_name": "G protein-activated inward rectifier potassium channel 4",
        "refseq_ac": [
            {
                "id": "NP_000881",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000881",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNJ5; GIRK4",
        "gene_names_refseq": "CIR; GIRK4; KATP1; KCNJ5; KIR3.4; LQT13",
        "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 4; CIR; Cardiac inward rectifier; GIRK-4; Heart KATP channel; IRK-4; Inward rectifier K(+) channel Kir3.4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5",
        "protein_names_refseq": "G protein-activated inward rectifier potassium channel 4; IRK-4; cardiac ATP-sensitive potassium channel; heart KATP channel; inward rectifier K+ channel KIR3.4; potassium channel, inwardly rectifying subfamily J, member 5; potassium voltage-gated channel subfamily J member 5",
        "tax_id": 9606,
        "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); familial hyperaldosteronism III (Disease Ontology:DOID:0061248); long QT syndrome 13 (Disease Ontology:DOID:0110654); primary hyperaldosteronism (Disease Ontology:DOID:446)",
        "pathway": " (hsa:3762);  (R-HSA-1296041);  (R-HSA-997272)",
        "pathway_count": 3,
        "publication_count": 30,
        "publication_id_list": "10659995;10889209;17185339;20453851;20560207;20655490;21311022;22203740;22275527;22308486;22315453;22628607;22848660;24037882;27099398;27293068;27862975;30429286;31154438;32502341;32983136;33537174;34185709;35580925;37894977;39192791;8047164;8558261;8834003;8868049",
        "class_list": "",
        "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]., [RefSeq]; [Research progress of KCNJ5 gene in aldosterone-producing adenoma]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R744;Q6DK13;Q6DK14;Q92807",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0005242 inward rectifier potassium channel activity",
        "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0099625 ventricular cardiac muscle cell membrane repolarization;GO:0086091 regulation of heart rate by cardiac conduction;GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "P48544-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000100000001.010.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P52732-1",
        "uniprot_id": [
            {
                "id": "KIF11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P52732",
                "type": "external"
            }
        ],
        "mass": 119159.0,
        "length": 1056,
        "protein_name": "Kinesin-like protein KIF11",
        "gene_name": "KIF11",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF11",
        "refseq_ac": [
            {
                "id": "NP_004514",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004514",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF11; EG5; KNSL1; TRIP5",
        "gene_names_refseq": "EG5; HKSP; KIF11; KNSL1; MCLMR; TRIP5",
        "protein_names_uniprotkb": "Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; TR-interacting protein 5; TRIP-5; Thyroid receptor-interacting protein 5",
        "protein_names_refseq": "TR-interacting protein 5; TRIP-5; kinesin-like protein 1; kinesin-like protein KIF11; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; thyroid receptor-interacting protein 5",
        "tax_id": 9606,
        "disease": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (Disease Ontology:DOID:0060349)",
        "pathway": " (hsa:3832);  (R-HSA-2132295);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 4,
        "publication_count": 307,
        "publication_id_list": "10.1101/2023.09.13.557529;10036229;10052452;10064083;10072072;10318838;10445031;10480952;10540230;10559959;10593899;10631941;10631952;10639150;10748235;10761932;10809954;10921873;11172815;11237011;11328809;11493604;11529500;11684289;11689559;11703931;11726511;11739780;11748249;11782313;11790530;11813165;11853874;12047556;12070132;12078484;12198549;12368902;12742663;12748383;1406973;14504276;14654841;14731593;15029241;15037235;15272311;15326200;15616190;15632110;15749704;15813748;15911768;16030262;1607388;16181339;16242130;16262723;1631136;16565220;16571679;16618111;16633337;1680566;16824007;16912714;16926190;16940185;16964243;17081983;17113389;17142755;17253781;17283181;17322306;17346968;17360540;17429068;17451557;17525332;17538014;17707232;17760859;17927562;17956946;18046453;18182008;18287528;18292509;18342609;18524849;18669648;18691976;18767875;18809720;1898986;19001501;19007248;19015319;19109418;19116309;19151722;19164740;19338388;19369418;19413330;1956401;19564404;1957170;19608861;19631211;19664994;19664995;19691289;19758564;20005805;20068230;20068231;20136777;20166139;20357002;20427317;20462495;20534429;20637885;21116285;2121367;21219331;21303978;2142332;21441454;21550981;21689688;21844168;2190094;22013193;22094269;22284827;22304919;22645359;22898188;23186163;23301498;23396477;23481700;23857769;2391366;24366607;24714562;24715725;2521221;2522352;25364732;25418920;25436559;25492864;25576301;25645385;25880248;26024233;26154972;26375851;26728094;26811146;26929215;26992070;27492783;27543614;27600516;27846572;27920218;28063628;28218747;28228285;28446606;28487562;28510447;28646493;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29786170;29899413;30315122;30410026;30429286;30484775;30524438;30779550;31092671;31154438;31217245;31222486;3130248;3134048;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32873777;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34229054;34405274;34509645;34561969;34932366;35051231;35318648;35494241;35561310;35580925;35977011;36010968;36215666;36241641;36284347;36581221;37656243;37728657;37938771;38424239;38672404;39085203;40914422;7481823;7528108;7539720;7592972;7650016;7667286;7776974;7822426;7844144;7929562;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8221884;8253837;8313912;8397411;8415765;8505331;8548803;8599929;8602245;8620540;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9114004;9177194;9202021;9235942;9244307;9288971;9311912;9312039;9405360;9497313;9539769;9545226;9606180;9701554;9751720;9990005",
        "class_list": "",
        "function": "Eg5 UFMylation promotes spindle organization during mitosis. Publication Status: Online-Only, [RefSeq, PubMed]; Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other., [RefSeq, PubMed]; KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia., [RefSeq, PubMed]; Mitotic Functions and Characters of KIF11 in Cancers. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769)., [UniProtKB, PubMed, PubMed]; This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]., [RefSeq]; UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV49;B2RMV3;Q15716;Q5VWX0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule",
        "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 31.2,
        "record_id": "P52732-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13886-1",
        "uniprot_id": [
            {
                "id": "KLF9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13886",
                "type": "external"
            }
        ],
        "mass": 27235.0,
        "length": 244,
        "protein_name": "Krueppel-like factor 9",
        "gene_name": "KLF9",
        "organism": "Human",
        "refseq_name": "Krueppel-like factor 9",
        "refseq_ac": [
            {
                "id": "NP_001197",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001197",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KLF9; BTEB1; BTEB",
        "gene_names_refseq": "BTEB1; BTEB; KLF9",
        "protein_names_uniprotkb": "Krueppel-like factor 9; BTE-binding protein 1; Basic transcription element-binding protein 1; GC-box-binding protein 1; Transcription factor BTEB1",
        "protein_names_refseq": "BTE-binding protein 1; GC-box-binding protein 1; Krueppel-like factor 9; Kruppel like factor 9; basic transcription element-binding protein 1; transcription factor BTEB1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:687);  (R-HSA-9764790)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "22711835;23186163;25576301;27862975;28832583;29557506;30206221;30542730;31154438;31848261;31957176;32157095;33227311;36241641;36420658;37962983;38062733;38195623;38520660;38649699;8051167;8291025",
        "class_list": "",
        "function": "Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression., [RefSeq, PubMed]; Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease., [RefSeq, PubMed]; Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis. Publication Status: Online-Only, [RefSeq, PubMed]; PAFAH1B3 is a KLF9 target gene that promotes proliferation and metastasis in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor KLF9 inhibits the proliferation, invasion, and migration of pancreatic cancer cells by repressing KIAA1522., [RefSeq, PubMed]; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R943;Q16196",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007623 circadian rhythm;GO:0010839 negative regulation of keratinocyte proliferation;GO:0071387 cellular response to cortisol stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q13886-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15334-1",
        "uniprot_id": [
            {
                "id": "L2GL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15334",
                "type": "external"
            }
        ],
        "mass": 115418.0,
        "length": 1064,
        "protein_name": "Lethal(2) giant larvae protein homolog 1",
        "gene_name": "LLGL1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "LLGL1; DLG4; HUGL1; HUGL",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Lethal(2) giant larvae protein homolog 1; DLG4; Hugl-1; Human homolog to the D-lgl gene protein; LLGL",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)",
        "pathway": " (hsa:3996)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11237011;12725730;15735678;16170365;20644714;23301498;23481700;25576301;26154972;26811146;26992070;27846572;28218747;28832583;28834231;28904123;29242379;29351928;29393594;29437277;29557506;30315122;30379171;30524438;30779550;31154438;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32938616;33298915;33392160;33537174;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34509645;34725712;35051231;35580925;36010968;36284347;37938771;7542763;8565641",
        "class_list": "",
        "function": "Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MBM7;O00188;Q58F11;Q86UK6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0007409 axonogenesis;GO:0030866 cortical actin cytoskeleton organization;GO:0006887 exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q15334-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5H943-1",
        "uniprot_id": [
            {
                "id": "KKLC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5H943",
                "type": "external"
            }
        ],
        "mass": 12784.0,
        "length": 113,
        "protein_name": "Kita-kyushu lung cancer antigen 1",
        "gene_name": "CT83",
        "organism": "Human",
        "refseq_name": "kita-kyushu lung cancer antigen 1",
        "refseq_ac": [
            {
                "id": "NP_001017978",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017978",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CT83; CXorf61; KKLC1",
        "gene_names_refseq": "CT83; CXorf61; KK-LC-1; KKLC1",
        "protein_names_uniprotkb": "Kita-kyushu lung cancer antigen 1; Cancer/testis antigen 83; KK-LC-1",
        "protein_names_refseq": "kita-kyushu lung cancer antigen 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:203413)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10.1101/2023.09.13.557529;16651449;25576301;26026129;26327325;28408606;28438869;30895661;31455429;32780528;33711953;33968037;34087483;34108519;34259140;35051231;35798537;35907786;37544663",
        "class_list": "",
        "function": "CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer., [RefSeq, PubMed]; Cancer-testis antigen KK-LC-1 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; KK-LC-1 may be an effective prognostic biomarker for gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; KK-LC-1 was frequently expressed in gastric cancer caused by H. pylori infection., [RefSeq, PubMed]; Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Six CT83-related Genes-based Prognostic Signature for Lung Adenocarcinoma., [RefSeq, PubMed]; The frequency of KK-LC-1 expression was higher than that of the other CTAs. KK-LC-1 might be a useful target for immunotherapy and in diagnosis of gastric cancer., [RefSeq, PubMed]; We defined the KK-LC-1/presenilin-1/Notch1/Hes1 as a novel signalling pathway that was involved in the growth and metastasis of hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q5H943-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PI47-1",
        "uniprot_id": [
            {
                "id": "KCD18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PI47",
                "type": "external"
            }
        ],
        "mass": 46739.0,
        "length": 426,
        "protein_name": "BTB/POZ domain-containing protein KCTD18",
        "gene_name": "KCTD18",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein KCTD18 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001308476",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308476",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCTD18",
        "gene_names_refseq": "6530404F10Rik; KCTD18",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD18",
        "protein_names_refseq": "BTB/POZ domain-containing protein KCTD18 isoform 1; BTB/POZ domain-containing protein KCTD18; potassium channel tetramerisation domain containing 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:130535)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "18984734;22645359;23054586;26154972;26552660;26992070;27846572;27893789;28063628;28218747;28832583;29242379;29437277;29485866;29493099;29557506;29632046;30315122;30379171;30410026;30833945;31092671;31217245;31844290;32157095;32161166;32574038;32938750;33633747;33912179;34087483;34171305;34846842;35051231;35254053;35580925;37541260;40596516",
        "class_list": "",
        "function": "A haplotype of 23 SNPs spanning 131.6 Kb shared by all affected members of 3 linked families with restless legs syndrome was identified. The shared candidate region covers 46.9 Kb over the potassium channel-related gene KCTD18 and exons 10-13 of SPATS2L., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53T21;Q6NW26;Q6PCD8;Q8N9B7;Q96N73",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0051260 protein homooligomerization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q6PI47-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UXX5-1",
        "uniprot_id": [
            {
                "id": "ITIH6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UXX5",
                "type": "external"
            }
        ],
        "mass": 143187.0,
        "length": 1313,
        "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H6",
        "gene_name": "ITIH6",
        "organism": "Human",
        "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H6 precursor",
        "refseq_ac": [
            {
                "id": "NP_940912",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940912",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ITIH6; ITIH5L; PRO21074",
        "gene_names_refseq": "ITIH5L; ITIH6; UNQ6369; dJ14O9.1",
        "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H6; Inter-alpha inhibitor H5-like protein; Inter-alpha-trypsin inhibitor heavy chain H5-like protein",
        "protein_names_refseq": "ITI-like protein; inter-alpha inhibitor H5-like protein; inter-alpha-trypsin inhibitor heavy chain H5-like protein; inter-alpha-trypsin inhibitor heavy chain H6 precursor; inter-alpha-trypsin inhibitor heavy chain H6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347365)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "12975309;24715725;28411811;29557506;30418433;32157095;32387766;33592498;33968037;34087483;35051231;38253038",
        "class_list": "",
        "function": "The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NN03",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0030212 hyaluronan metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q6UXX5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUG1-1",
        "uniprot_id": [
            {
                "id": "KRA13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUG1",
                "type": "external"
            }
        ],
        "mass": 17141.0,
        "length": 167,
        "protein_name": "Keratin-associated protein 1-3",
        "gene_name": "KRTAP1-3",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 1-3",
        "refseq_ac": [
            {
                "id": "NP_112228",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112228",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRTAP1-3; B2B; KAP1.2; KAP1.3; KAP1.8; KAP1.9; KRATP1.9; KRTAP1.8",
        "gene_names_refseq": "KAP1.2; KAP1.3; KAP1.6; KAP1.8A; KAP1.8B; KAP1.9; KRTAP1-3; KRTAP1.3",
        "protein_names_uniprotkb": "Keratin-associated protein 1-3; Keratin-associated protein 1.8; Keratin-associated protein 1.9",
        "protein_names_refseq": "keratin associated protein 1.6; keratin-associated protein 1-3; keratin-associated protein 1.8; keratin-associated protein 1.9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81850);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 13,
        "publication_id_list": "11279113;12228244;1279380;15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Polymorphisms in Japanese and Caucasian individuals, [RefSeq, PubMed]; This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q07628;Q8IUG0;Q9BYS2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8IUG1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N5I3-1",
        "uniprot_id": [
            {
                "id": "KCNRG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N5I3",
                "type": "external"
            }
        ],
        "mass": 31048.0,
        "length": 272,
        "protein_name": "Potassium channel regulatory protein",
        "gene_name": "KCNRG",
        "organism": "Human",
        "refseq_name": "potassium channel regulatory protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_775876",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775876",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNRG; CLLD4",
        "gene_names_refseq": "DLTET; KCNRG",
        "protein_names_uniprotkb": "Potassium channel regulatory protein; Potassium channel regulator; Protein CLLD4",
        "protein_names_refseq": "potassium channel regulatory protein isoform 1; putative potassium channel regulatory protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283518)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "12650944;16819283;19251657;19413330;19968958;20237900;25576301;31530632",
        "class_list": "",
        "function": "Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms in autoimmune polyendocrine syndrome type 1, [RefSeq, PubMed]; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes., [UniProtKB, PubMed, PubMed]; KCNRG is an ER-associated protein, which is proposed to regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes., [RefSeq, PubMed]; Results suggest that genetic alterations and the expression of KCNRG might play an important role in the development and/or progression of a subset of hepatocellular carcinoma., [RefSeq, PubMed]; The haploinsufficiency of KCNRG might be relevant to the progression of chronic lymphocytic leukemia (CLL)and multiple myeloma(MM) at least in a subset of patients., [RefSeq, PubMed]; The primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene GeneRIF: KCNRG suppresses K+ channel activity in human prostate cell line LNCaP., [RefSeq, PubMed]; This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2X9;Q0P6D0;Q8IU75;Q8N3Q9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:1902260 negative regulation of delayed rectifier potassium channel activity",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8N5I3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NC54-1",
        "uniprot_id": [
            {
                "id": "KCT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NC54",
                "type": "external"
            }
        ],
        "mass": 29235.0,
        "length": 265,
        "protein_name": "Keratinocyte-associated transmembrane protein 2",
        "gene_name": "KCT2",
        "organism": "Human",
        "refseq_name": "keratinocyte-associated transmembrane protein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_064584",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064584",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCT2; C5orf15; HTGN29",
        "gene_names_refseq": "C5orf15; HTGN29; KCT2",
        "protein_names_uniprotkb": "Keratinocyte-associated transmembrane protein 2",
        "protein_names_refseq": "keratinocyte-associated transmembrane protein 2 precursor; keratinocyte-associated transmembrane protein 2; keratinocytes associated transmembrane protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56951)",
        "pathway_count": 1,
        "publication_count": 61,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;12752121;19651622;20068231;20187088;23186163;23481700;23584533;24714562;25502872;25576301;25645385;25813380;26154972;26728094;26811146;26992070;27452731;27600516;27862975;28832583;28834231;28904123;29242379;29393594;29557506;29786170;29789417;30315122;30429286;30833945;31154438;31611695;31844290;32157095;32350084;32387766;32897882;32938616;32983136;33298915;33592498;33691108;33717175;33968037;34078123;34171305;34211107;34357683;34433824;34509645;34932366;35051231;35154160;35251023;35561310;35580925;36284347;40307207",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD10;D3DQ92;Q9NRG2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q8NC54-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TBQ9-1",
        "uniprot_id": [
            {
                "id": "KISHA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TBQ9",
                "type": "external"
            }
        ],
        "mass": 8060.0,
        "length": 72,
        "protein_name": "Protein kish-A",
        "gene_name": "TMEM167A",
        "organism": "Human",
        "refseq_name": "protein kish-A precursor",
        "refseq_ac": [
            {
                "id": "NP_777569",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777569",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM167A; TMEM167",
        "gene_names_refseq": "TMEM167A; TMEM167; kish",
        "protein_names_uniprotkb": "Protein kish-A; Transmembrane protein 167A; Transmembrane protein 167",
        "protein_names_refseq": "protein kish-A precursor; protein kish-A; transmembrane protein 167",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:153339)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "19942856;24715725;27600516;28510447;28514659;28904123;29557506;30315122;30506943;31844290;32387766;32938616;33141586;33392160;33592498;35051231;35580925;37938771;38665916",
        "class_list": "",
        "function": "DISCUSSION The results presented here show that kish/TMEM167A, a protein associated with vesicle transport and secretion,also is necessary for glioma growth, both in human cell xenografts and Drosophila models., [RefSeq, PubMed]; Involved in the early part of the secretory pathway., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0P692",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0009306 protein secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8TBQ9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96AC6-1",
        "uniprot_id": [
            {
                "id": "KIFC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96AC6",
                "type": "external"
            }
        ],
        "mass": 90147.0,
        "length": 838,
        "protein_name": "Kinesin-like protein KIFC2",
        "gene_name": "KIFC2",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIFC2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_665697",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665697",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIFC2",
        "gene_names_refseq": "KIFC2",
        "protein_names_uniprotkb": "Kinesin-like protein KIFC2",
        "protein_names_refseq": "kinesin-like protein KIFC2 isoform 1; kinesin-like protein KIFC2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90990);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 3,
        "publication_count": 122,
        "publication_id_list": "10052452;10318838;10445031;10559959;10761932;10921873;11172815;11237011;11493604;11689559;11703931;11726511;11739780;11748249;11782313;12047556;12070132;12368902;1406973;14504276;14654841;15029241;15037235;15272311;15326200;15616190;15632110;15813748;16030262;1607388;16262723;1631136;16571679;16633337;1680566;16912714;16926190;16940185;17113389;17253781;17346968;17360540;17429068;17451557;17538014;17760859;17927562;17956946;18182008;18287528;18342609;18524849;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1957170;19631211;19758564;20005805;20136777;20357002;20427317;20462495;20534429;20637885;21219331;2142332;21550981;21689688;21844168;22013193;22094269;22130050;22304919;23396477;24714562;24715725;2521221;2522352;25364732;25436559;25492864;26992070;27893789;29557506;30429286;3130248;3134048;31530632;31844290;35051231;35318648;37716704;37904433;7528108;7539720;7822426;7844144;7929562;8001155;8128252;8132710;8221884;8253837;8505331;8548803;8599929;8602245;8620540;9114004;9177194;9244307;9288971;9405360;9751720;9990005",
        "class_list": "",
        "function": "Expression level of KIF2C mRNA could be a potential independent marker to evaluate patient prognosis, [RefSeq, PubMed]; Kinesin superfamily member KIFC2 as an independent prognostic biomarker of colon adenocarcinoma associated with poor immune response., [RefSeq, PubMed]; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65. Erratum:[J Biol Chem. 2025 Aug;301(8):110461. doi: 10.1016/j.jbc.2025.110461. PMID: 40753650], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PHB2;Q96NN6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0032839 dendrite cytoplasm",
        "go_biological_process": "GO:0007411 axon guidance;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0048489 synaptic vesicle transport;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q96AC6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H3M0-1",
        "uniprot_id": [
            {
                "id": "KCNF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H3M0",
                "type": "external"
            }
        ],
        "mass": 55584.0,
        "length": 494,
        "protein_name": "Voltage-gated potassium channel regulatory subunit KCNF1",
        "gene_name": "KCNF1",
        "organism": "Human",
        "refseq_name": "voltage-gated potassium channel regulatory subunit KCNF1",
        "refseq_ac": [
            {
                "id": "NP_002227",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002227",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNF1",
        "gene_names_refseq": "IK8; KCNF1; KCNF; KV5.1; kH1",
        "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNF1; Potassium voltage-gated channel subfamily F member 1; Voltage-gated potassium channel subunit Kv5.1; kH1",
        "protein_names_refseq": "potassium channel KH1; voltage-gated potassium channel regulatory subunit KCNF1; voltage-gated potassium channel subunit Kv5.1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3754);  (R-HSA-1296072)",
        "pathway_count": 2,
        "publication_count": 10,
        "publication_id_list": "20393197;21231794;23481700;29393594;31092671;31154438;31844290;35318648;36385523;9434767",
        "class_list": "",
        "function": "KCNF1 promotes lung cancer by modulating ITGB4 expression., [RefSeq, PubMed]; Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone., [UniProtKB, UniProtKB]; Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43527;Q585L3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex;GO:0097546 ciliary base",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0043266 regulation of potassium ion transport;GO:1905515 non-motile cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9H3M0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRX6-1",
        "uniprot_id": [
            {
                "id": "KISHB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRX6",
                "type": "external"
            }
        ],
        "mass": 8294.0,
        "length": 74,
        "protein_name": "Protein kish-B",
        "gene_name": "TMEM167B",
        "organism": "Human",
        "refseq_name": "protein kish-B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001309177",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309177",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM167B; AD-020; C1orf119",
        "gene_names_refseq": "AD-020; C1orf119; TMEM167B",
        "protein_names_uniprotkb": "Protein kish-B; Transmembrane protein 167B",
        "protein_names_refseq": "protein kish-B isoform 2; protein kish-B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56900)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10931946;11237011;19942856;25880248;28904123;31844290;32350084;32357974;32938616;33043033;34509645;35251023;36215666",
        "class_list": "",
        "function": "Involved in the early part of the secretory pathway., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUU9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0045054 constitutive secretory pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9NRX6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRX4-1",
        "uniprot_id": [
            {
                "id": "PHP14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRX4",
                "type": "external"
            }
        ],
        "mass": 13833.0,
        "length": 125,
        "protein_name": "14 kDa phosphohistidine phosphatase",
        "gene_name": "PHPT1",
        "organism": "Human",
        "refseq_name": "14 kDa phosphohistidine phosphatase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001129333",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129333",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHPT1; CGI-202; HSPC141; PHP14",
        "gene_names_refseq": "CGI-202; HEL-S-132P; HSPC141; PHP14; PHPT1; PHP",
        "protein_names_uniprotkb": "14 kDa phosphohistidine phosphatase; 3.9.1.3; PHPT1; PHP; Phosphohistidine phosphatase 1; Protein histidine phosphatase; Protein janus-A homolog",
        "protein_names_refseq": "14 kDa phosphohistidine phosphatase isoform 2; 14 kDa phosphohistidine phosphatase; epididymis secretory sperm binding protein Li 132P; protein histidine phosphatase; protein janus-A homolog; sex-regulated protein janus-a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29085)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "10931946;11230166;11342225;12383260;16219293;16990267;18991813;19836471;22223895;22645359;24715725;25574816;26154972;26992070;27600516;27920218;28218747;28832583;28834231;28904123;29242379;29437277;29508533;29557506;29630837;29786170;29787434;30410026;30429286;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33592498;33717175;33912179;33936100;34019948;34087483;34171305;34229054;34932366;35051231;35251023;35411430;35580925;36010968;36284347;37938771;38665916;38747379",
        "class_list": "glycogene",
        "function": "A salt bridge of the C-terminal carboxyl group regulates PHPT1 substrate affinity and catalytic activity., [RefSeq, PubMed]; Exhibits phosphohistidine phosphatase activity., [UniProtKB, PubMed, PubMed]; FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer., [RefSeq, PubMed]; High PHPT1 expression is associated with cancer., [RefSeq, PubMed]; In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +/- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +/- 1 and 490 +/- 20 muM, [RefSeq, PubMed]; Northern blot analysis indicated that the human phosphohistidine phosphatase mRNA was present preferentially in heart and skeletal muscle., [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 217,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AMX0;B1AMX1;Q9H0Y3",
        "ec_number_list": [
            {
                "id": "3.9.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity;GO:0101006 protein histidine phosphatase activity",
        "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0030036 actin cytoskeleton organization;GO:2000147 positive regulation of cell motility;GO:0097581 lamellipodium organization;GO:0050860 negative regulation of T cell receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9NRX4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13835-1",
        "uniprot_id": [
            {
                "id": "PKP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13835",
                "type": "external"
            }
        ],
        "mass": 82861.0,
        "length": 747,
        "protein_name": "Plakophilin-1",
        "gene_name": "PKP1",
        "organism": "Human",
        "refseq_name": "plakophilin-1 isoform 1b",
        "refseq_ac": [
            {
                "id": "NP_000290",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000290",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKP1",
        "gene_names_refseq": "B6P; EDSFS; PKP1",
        "protein_names_uniprotkb": "Plakophilin-1; B6P; Band 6 protein",
        "protein_names_refseq": "band 6 protein; plakophilin-1 isoform 1b",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ectodermal dysplasia (Disease Ontology:DOID:2121); epidermolysis bullosa simplex due to plakophilin deficiency (MONDO:MONDO:0011472)",
        "pathway": " (hsa:5317);  (R-HSA-351906);  (R-HSA-6798695);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 5,
        "publication_count": 95,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10748026;10771479;10852826;11076937;11350120;11380615;11500511;11590230;11790773;12902340;15033990;15054114;15337775;15373777;15663951;15797384;15803139;16061697;16286477;16382671;16639001;1691188;1694855;1714783;17515931;17521629;17559062;17562024;17596512;18083107;18843291;19190773;19194479;20068231;20156963;20179351;20613778;20657595;20667819;20940292;21439340;21654840;21756917;21997417;23444369;23481192;23629652;23650620;24029068;2414304;25208914;25225333;25576301;25926655;26390218;29393594;29678907;29786170;30397120;30949721;31835537;31844290;31998317;32157095;33141586;33968037;34019948;34087483;34171305;34185709;35051231;35182388;35318648;35580925;36284347;36372391;36380691;37114302;38665916;38785968;7527055;7543090;8692836;8824274;8999895;9326952;9369526;9395522;9468612;9565599",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Elucidation of the inhibitory potential of flavonoids against PKP1 protein in non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer., [RefSeq, PubMed]; Plakophilin 1 deficiency in prostatic tumours is correlated with immune cell recruitment and controls the up-regulation of cytokine expression post-transcriptionally., [RefSeq, PubMed]; The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4., [RefSeq, PubMed]; This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]., [RefSeq]; Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00645;Q14CA0;Q15152",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0005521 lamin binding;GO:0019215 intermediate filament binding",
        "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0045110 intermediate filament bundle assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "Q13835-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99500-1",
        "uniprot_id": [
            {
                "id": "S1PR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99500",
                "type": "external"
            }
        ],
        "mass": 42250.0,
        "length": 378,
        "protein_name": "Sphingosine 1-phosphate receptor 3",
        "gene_name": "S1PR3",
        "organism": "Human",
        "refseq_name": "sphingosine 1-phosphate receptor 3",
        "refseq_ac": [
            {
                "id": "NP_005217",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005217",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S1PR3; C9orf108; C9orf47; EDG3",
        "gene_names_refseq": "C9orf108; C9orf47; EDG-3; EDG3; LPB3; S1P3; S1PR3; bA791O21.3",
        "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 3; Endothelial differentiation G protein-coupled receptor 3; S1P receptor 3; S1P receptor Edg-3; S1P3; Sphingosine 1-phosphate receptor Edg-3",
        "protein_names_refseq": "G protein-coupled receptor, endothelial differentiation gene-3; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; sphingosine 1-phosphate receptor 3; sphingosine 1-phosphate receptor Edg-3; uncharacterized protein C9orf47",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1903);  (R-HSA-418594);  (R-HSA-419408);  (R-HSA-9009391)",
        "pathway_count": 4,
        "publication_count": 123,
        "publication_id_list": "10319328;10383399;10427092;10488065;10488122;10617617;10727522;10749889;10753843;10799507;10806474;10908314;11007482;11029009;11029403;11043579;11044445;11185956;11369763;11689445;11773442;11773443;11825873;11981029;12048194;12120503;12388769;12421825;12427546;12431978;12511868;12588983;12682286;12730698;12808053;12881510;1378832;14764897;15033483;15044318;15090535;15231873;15314172;15467163;15496458;15569929;15657067;15705661;15951850;15956360;16239258;16274718;16634148;16636149;16645038;16835357;16923326;17037979;17424910;17525128;17535799;17916740;17921256;18206197;18434541;18577758;18578522;18657504;19138696;19366702;19879889;20061941;20439495;20650261;20861220;2160972;21680538;21851428;22028449;22031296;22266855;22446104;23186163;23388400;24039841;24530924;24900670;2534964;25587652;26990079;27288742;2748346;2834384;28411811;28539435;29735753;29738483;32938616;33592498;33968037;34087483;36543771;37120767;38109696;38163647;38852936;7526779;7750475;7937899;8015379;8406495;8626678;8782602;8876252;8878560;9070858;9173876;9395517;9409733;9525886;9565625;9616126;9804623",
        "class_list": "",
        "function": "Extracellular alpha-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells., [RefSeq, PubMed]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis., [UniProtKB, PubMed]; SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway., [RefSeq, PubMed]; Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells., [RefSeq, PubMed]; Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways., [RefSeq, PubMed]; Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM). Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SQD8;Q7Z5I2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0008289 lipid binding;GO:0038036 sphingosine-1-phosphate receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q99500-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HD15-1",
        "uniprot_id": [
            {
                "id": "SRA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HD15",
                "type": "external"
            }
        ],
        "mass": 24400.0,
        "length": 224,
        "protein_name": "Steroid receptor RNA activator 1",
        "gene_name": "SRA1",
        "organism": "Human",
        "refseq_name": "steroid receptor RNA activator 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001030312",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030312",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SRA1; PP7684",
        "gene_names_refseq": "SRA1; SRAP; SRA; STRAA1; pp7684",
        "protein_names_uniprotkb": "Steroid receptor RNA activator 1; SRAP; Steroid receptor RNA activator protein",
        "protein_names_refseq": "lncRNA SRA; steroid receptor RNA activator 1 (complexes with NCOA1); steroid receptor RNA activator 1 isoform 1; steroid receptor RNA activator protein; steroid receptor coactivator",
        "tax_id": 9606,
        "disease": "congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:10011)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "10199399;11237011;12565891;12943696;14517287;15147866;15351741;15498874;16152589;18669648;19415658;20068231;22362738;22544926;22898188;23186163;23481700;24275569;25645385;25892735;27600516;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28860189;29242379;29331515;29393594;29508533;29632046;29769354;29786170;30315122;30524438;30779550;31222486;31373491;31848261;31937595;31998317;34019948;36215666;36552771;37143083;37938771",
        "class_list": "",
        "function": "A report of the first experimentally derived secondary structure of a human lncRNA, the steroid receptor RNA activator., [RefSeq, PubMed]; Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]., [RefSeq]; Data suggest that the presence of both coding SRA RNA and its corresponding SRAP modifies the activity of estrogen receptor in breast cancer cells and that SRAP could be a new clinical marker for breast cancer, [RefSeq, PubMed]; Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity. Publication Status: Online-Only, [RefSeq, PubMed]; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NVU9;Q8IXM1;Q9HD13;Q9HD14",
        "ec_number_list": [],
        "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0045662 negative regulation of myoblast differentiation;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q9HD15-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q08334-1",
        "uniprot_id": [
            {
                "id": "I10R2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q08334",
                "type": "external"
            }
        ],
        "mass": 36995.0,
        "length": 325,
        "protein_name": "Interleukin-10 receptor subunit beta",
        "gene_name": "IL10RB",
        "organism": "Human",
        "refseq_name": "interleukin-10 receptor subunit beta isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_000619",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000619",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL10RB; CRFB4; D21S58; D21S66",
        "gene_names_refseq": "CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IBD25; IL-10R2; IL-10RB; IL10RB",
        "protein_names_uniprotkb": "Interleukin-10 receptor subunit beta; CRF2-4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10R2; IL-10RB; Interleukin-10 receptor subunit 2",
        "protein_names_refseq": "IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; cytokine receptor class-II CRF2-4; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; cytokine receptor family II, member 4; interleukin 10 receptor, beta; interleukin-10 receptor subunit 2; interleukin-10 receptor subunit beta isoform 1 precursor",
        "tax_id": 9606,
        "disease": "graft-versus-host disease (Disease Ontology:DOID:0081267); inflammatory bowel disease 25 (Disease Ontology:DOID:0110909); hepatitis B (Disease Ontology:DOID:2043); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); hepatitis B virus, susceptibility to (MONDO:MONDO:0012488)",
        "pathway": " (hsa:3588);  (R-HSA-449836);  (R-HSA-6783783);  (R-HSA-8854691)",
        "pathway_count": 4,
        "publication_count": 142,
        "publication_id_list": "10.1101/2023.09.13.557529;10092818;10395686;10415057;10433356;10438516;10875937;11163236;11196675;11237011;11390453;11390454;11481447;11564763;11706020;12087100;12351624;12469119;12554859;12558796;12626585;12832402;14580208;1460289;14764663;15120653;15123776;15166220;15178681;15340161;15919823;16488976;16492764;1662392;16750817;16757563;16982608;17878297;18467591;18507432;18599299;18669613;18830264;18941194;1940369;1940799;19413330;19457860;19535621;19890111;20145033;20462497;20671117;20966397;21098725;2147944;21716315;22802649;22962576;23291588;23481700;23519428;23744080;24190977;24715725;24743777;25004819;25662098;26095744;27133025;27405747;27846572;28218747;28228285;28458652;28832583;28904123;29242379;29393594;29437277;29632711;29769354;31217245;31844290;32350084;32357974;32387766;32938616;33298915;33392160;34171305;34185709;34357683;34433824;34932366;35051231;35205336;35251023;35494241;35811529;36010968;37503744;37511050;7510216;7512027;7512451;7516408;7543512;7563119;7593617;7594602;7615501;7684412;7687627;7805849;7902377;8063757;8102388;8120391;8163946;8186324;8301137;8314576;8537680;8662928;8734788;8742066;8830676;8871669;8897595;8910398;8921438;8946277;9013939;9312047;9354687;9422780;9449724;9550426;9794440;9836587;9918218",
        "class_list": "",
        "function": "Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. Publication Status: Online-Only, [RefSeq, PubMed]; Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical and cellular phenotypes resulting from a founder mutation in IL10RB., [RefSeq, PubMed]; Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9., [RefSeq, PubMed]; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BUU4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004920 interleukin-10 receptor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032002 interleukin-28 receptor complex",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0051607 defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "Q08334-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95136-1",
        "uniprot_id": [
            {
                "id": "S1PR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95136",
                "type": "external"
            }
        ],
        "mass": 38867.0,
        "length": 353,
        "protein_name": "Sphingosine 1-phosphate receptor 2",
        "gene_name": "S1PR2",
        "organism": "Human",
        "refseq_name": "sphingosine 1-phosphate receptor 2",
        "refseq_ac": [
            {
                "id": "NP_004221",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004221",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S1PR2; EDG5",
        "gene_names_refseq": "AGR16; DFNB68; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2; S1PR2",
        "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 2; Endothelial differentiation G protein-coupled receptor 5; S1P receptor 2; S1P receptor Edg-5; S1P2; Sphingosine 1-phosphate receptor Edg-5",
        "protein_names_refseq": "CTD-2369P2.2; S1P receptor 2; S1P receptor EDG5; S1P receptor Edg-5; deafness, autosomal recessive 68; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5; sphingosine 1-phosphate receptor 2; sphingosine 1-phosphate receptor Edg-5",
        "tax_id": 9606,
        "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); autosomal recessive nonsyndromic deafness 68 (Disease Ontology:DOID:0110519); vestibular schwannomatosis (Disease Ontology:DOID:0111252); otitis media (Disease Ontology:DOID:10754); coloboma (Disease Ontology:DOID:12270); acoustic neuroma (Disease Ontology:DOID:12689); epilepsy (Disease Ontology:DOID:1826); carcinoma (Disease Ontology:DOID:305); neurilemmoma (Disease Ontology:DOID:3192); meningioma (Disease Ontology:DOID:3565); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:9294);  (R-HSA-418594);  (R-HSA-419408)",
        "pathway_count": 3,
        "publication_count": 66,
        "publication_id_list": "10.1101/2023.09.13.557529;10488065;10488122;10617617;10727522;10753843;10799507;11007482;12120503;12427546;12730698;15951850;16634148;16923326;18434541;18577758;19366702;20061941;2160972;23388400;24190977;24900670;25274307;2534964;26805784;26990079;26992070;2748346;27920218;28218747;2834384;28832583;28834231;28904123;29242379;29314611;29393594;29437277;29453251;29735753;29786170;30315122;30410026;31844290;32350084;33298915;33717175;33912179;33936100;34357683;34932366;35051231;35580925;37301709;37727014;38007654;38061028;38484568;7937899;8015379;8406495;8626678;8878560;9070858;9525886;9804623",
        "class_list": "",
        "function": "Activation of S1P2 is protective against cisplatin-induced peripheral neuropathy., [RefSeq, PubMed]; Is myeloid-derived growth factor a ligand of the sphingosine-1-phosphate receptor 2?, [RefSeq, PubMed]; Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity., [RefSeq, PubMed]; Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophoblasts., [RefSeq, PubMed]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; S1PR2 Regulates Autophagy Through the AKT/mTOR Pathway to Promote Pathological Damage in Alzheimer's Disease., [RefSeq, PubMed]; This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 17,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86UN8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0001664 G protein-coupled receptor binding;GO:0008289 lipid binding;GO:0008528 G protein-coupled peptide receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse",
        "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0046847 filopodium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "O95136-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q0VDF9-1",
        "uniprot_id": [
            {
                "id": "HSP7E_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q0VDF9",
                "type": "external"
            }
        ],
        "mass": 54794.0,
        "length": 509,
        "protein_name": "Heat shock 70 kDa protein 14",
        "gene_name": "HSPA14",
        "organism": "Human",
        "refseq_name": "heat shock 70 kDa protein 14",
        "refseq_ac": [
            {
                "id": "NP_057383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSPA14; HSP60; HSP70L1",
        "gene_names_refseq": "HSP70-4; HSP70L1; HSPA14",
        "protein_names_uniprotkb": "Heat shock 70 kDa protein 14; HSP70-like protein 1; Heat shock protein HSP60; Heat shock protein family A member 14",
        "protein_names_refseq": "HSP70-like protein 1; heat shock 70 kDa protein 14; heat shock protein HSP60; heat shock protein family A member 14; heat shock protein hsp70-related protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51182);  (R-HSA-3371453)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10.1101/2023.09.13.557529;10931946;10954706;11237011;11747420;12853476;12917326;12974469;14592822;15364926;15802566;1586970;15930317;16002468;16278218;16385451;16959974;1754405;18235501;18235502;18550409;18818748;18851947;19229036;19914676;20068231;22465953;22541429;22706990;22735644;22940245;23301498;23349863;24366607;24714562;24715725;25576301;25645385;26154972;26375851;26728094;26811146;26992070;27600516;27846572;27920218;28063628;28228285;28446606;28510447;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30484775;30779550;31092671;31154438;31222486;31530632;31616780;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33592498;33717175;33912179;33968037;33981976;34019948;34171305;34211107;34509645;34932366;35051231;35251023;35318648;35580925;36215666;36241641;36284347;36845091;7585962;8721986;8946918;9305631;9873016;9920933",
        "class_list": "",
        "function": "Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity., [UniProtKB, PubMed]; Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication. Publication Status: Online-Only, [RefSeq, PubMed]; HSP70L1 expression is induced by TERT.TERT promotes formation of a telomere protective complex containing Hsp70L1. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results demonstrate that Hsp70L1 has enhanced Th1 polarizing and adjuvant properties, which appear to be mediated via activation of dendritic cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8F8;B0YIY9;Q9P0X2;Q9UI07",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006457 protein folding;GO:0042026 protein refolding",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q0VDF9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60725-1",
        "uniprot_id": [
            {
                "id": "ICMT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60725",
                "type": "external"
            }
        ],
        "mass": 31938.0,
        "length": 284,
        "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase",
        "gene_name": "ICMT",
        "organism": "Human",
        "refseq_name": "protein-S-isoprenylcysteine O-methyltransferase",
        "refseq_ac": [
            {
                "id": "NP_036537",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICMT; PCCMT",
        "gene_names_refseq": "HSTE14; ICMT; MST098; MSTP098; PCCMT; PCMT; PPMT",
        "protein_names_uniprotkb": "Protein-S-isoprenylcysteine O-methyltransferase; 2.1.1.100; Isoprenylcysteine carboxylmethyltransferase; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; pcCMT",
        "protein_names_refseq": "prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methyltransferase; protein-S-isoprenylcysteine O-methyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23463);  (R-HSA-163841);  (R-HSA-9648002)",
        "pathway_count": 3,
        "publication_count": 121,
        "publication_id_list": "10085068;10085069;10649571;10667208;11016445;11038283;11120601;11196150;11237011;11585916;11739732;11906819;12433685;12727204;12750467;14561760;14633848;14660603;14966563;15102834;15137908;15451670;1554716;15659645;16000296;16043511;16483930;18182391;18502828;18672380;19158273;19188362;20416930;20418879;20622895;20802526;21170358;21661760;21779505;21905185;21905186;22002721;22144181;22179043;22195972;22589270;22721555;23481380;23514631;23698361;23943869;24033119;24715725;24725411;24971579;25059662;25418920;25550383;25713064;25759176;25781681;25892735;26085527;26590425;2661017;26701913;26706195;26771141;2682646;26929215;26992070;27094677;27396271;27410739;27697864;27791178;27846572;27862975;27920218;28063628;28167504;28218747;28228285;28630138;28666118;28778966;28832583;28834231;28904123;29311131;29424242;29437277;29769354;29786170;30315122;30429286;31217245;31844290;32350084;32387766;32877642;32938616;33392160;33579760;33592498;33717175;33912179;34087483;34509645;35051231;35312113;35914811;36284347;38301884;8051097;9436858;9501187;9614111;9810004;9822558;9851253",
        "class_list": "",
        "function": "Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues., [UniProtKB, PubMed]; CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis., [RefSeq, PubMed]; Isoprenylcysteine carboxyl methyltransferase (ICMT) promotes invadopodia formation and metastasis in cancer cells., [RefSeq, PubMed]; Modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma cells, [RefSeq, PubMed]; NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. Publication Status: Online-Only, [RefSeq, PubMed]; PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FHT0",
        "ec_number_list": [
            {
                "id": "2.1.1.100",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003880 protein C-terminal carboxyl O-methyltransferase activity;GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0036211 protein modification process;GO:0006612 protein targeting to membrane;GO:0046498 S-adenosylhomocysteine metabolic process;GO:0006481 C-terminal protein methylation;GO:0046499 S-adenosylmethioninamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "O60725-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H9V9-3",
        "uniprot_id": [
            {
                "id": "JMJD4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H9V9",
                "type": "external"
            }
        ],
        "mass": 47425.0,
        "length": 417,
        "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4",
        "gene_name": "JMJD4",
        "organism": "Human",
        "refseq_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001154937",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154937",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "JMJD4",
        "gene_names_refseq": "JMJD4",
        "protein_names_uniprotkb": "2-oxoglutarate and iron-dependent oxygenase JMJD4; 1.14.11.-; JmjC domain-containing protein 4; Jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4",
        "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform 2; 2-oxoglutarate and iron-dependent oxygenase JMJD4; 2-oxoglutarate- and Fe(II)-dependent oxygenase; C4 lysyl hydroxylase; jmjC domain-containing protein 4; jumonji domain-containing protein 4; lysyl-hydroxylase JMJD4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:65094);  (R-HSA-9629569)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "1378441;15676025;17947579;1856229;19574390;19819225;20684070;21060799;22851697;23103944;23303181;24100311;24486019;24550447;24550462;24550463;25728928;26758079;27920218;28218747;28832583;28855257;29563586;29914368;29915238;30029884;30315122;30833945;31154438;37066795;6688526",
        "class_list": "",
        "function": "Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1., [UniProtKB, PubMed]; It observed significant positivity of JMJD4 between 59 paired samples from colon adenocarcinoma (CA) tissue and adjacent normal tissue. JMJD4 protein expression in CA differed significantly according to the histological grade and M-class (distant metastasis)., [RefSeq, PubMed]; Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy. Erratum:[Circulation. 2024 Jul 9;150(2):e64. doi: 10.1161/CIR.0000000000001268. PMID: 38976614], [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WT84;Q5TBZ1;Q5TBZ6;Q9H970",
        "ec_number_list": [
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0106156 peptidyl-lysine 4-dioxygenase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0045905 positive regulation of translational termination;GO:0017185 peptidyl-lysine hydroxylation;GO:0018126 protein hydroxylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9H9V9-3",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05981-1",
        "uniprot_id": [
            {
                "id": "HEPS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05981",
                "type": "external"
            }
        ],
        "mass": 45011.0,
        "length": 417,
        "protein_name": "Serine protease hepsin",
        "gene_name": "HPN",
        "organism": "Human",
        "refseq_name": "serine protease hepsin precursor",
        "refseq_ac": [
            {
                "id": "NP_002142",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002142",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HPN; TMPRSS1",
        "gene_names_refseq": "HPN; TMPRSS1",
        "protein_names_uniprotkb": "Serine protease hepsin; 3.4.21.106; Transmembrane protease serine 1",
        "protein_names_refseq": "serine protease hepsin precursor; serine protease hepsin; testicular tissue protein Li 85; transmembrane protease serine 1",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:3249);  (R-HSA-6806942);  (R-HSA-8852405)",
        "pathway_count": 3,
        "publication_count": 49,
        "publication_id_list": "11237011;12726861;1280830;12962630;15167892;15218027;15301554;15324701;15632155;15713485;15792801;15839837;16537482;1655790;1885621;19159218;20228799;20545605;20726546;21875933;22087277;23721092;24227843;24409221;24715725;25193665;26673890;2835076;31844290;32553951;33300264;36802168;37013685;37074911;37872868;7513258;7651534;7708691;7854452;7854453;8197126;8208547;8302603;8346233;9045658;9140397;9202013;9346890;9657372",
        "class_list": "",
        "function": "Hepsin promotes breast tumor growth signaling via the TGFbeta-EGFR axis., [RefSeq, PubMed]; Hepsin: a multifunctional transmembrane serine protease in pathobiology. Review article, [RefSeq, PubMed]; N-glycosylation mediated folding and quality control in serine proteases of the hepsin family., [RefSeq, PubMed]; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). Plays a role in cell growth and maintenance of cell morphology (PubMed:21875933, PubMed:8346233). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Spatial position is a key determinant of N-glycan functionality of the scavenger receptor cysteine-rich domain of human hepsin., [RefSeq, PubMed]; This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 9562,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDS4",
        "ec_number_list": [
            {
                "id": "3.4.21.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.106",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity;GO:0070008 serine-type exopeptidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0016020 membrane;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0010756 positive regulation of plasminogen activation;GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0016485 protein processing",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "P05981-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P32942-1",
        "uniprot_id": [
            {
                "id": "ICAM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P32942",
                "type": "external"
            }
        ],
        "mass": 59541.0,
        "length": 547,
        "protein_name": "Intercellular adhesion molecule 3",
        "gene_name": "ICAM3",
        "organism": "Human",
        "refseq_name": "intercellular adhesion molecule 3 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002153",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002153",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICAM3",
        "gene_names_refseq": "CD50; CDW50; ICAM-R; ICAM3",
        "protein_names_uniprotkb": "Intercellular adhesion molecule 3; CDw50; ICAM-3; ICAM-R",
        "protein_names_refseq": "ICAM-3; intercellular adhesion molecule 3 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)",
        "pathway": " (hsa:3385);  (R-HSA-198933);  (R-HSA-216083);  (R-HSA-5621575)",
        "pathway_count": 4,
        "publication_count": 222,
        "publication_id_list": "10209034;10366422;10438935;10499918;10543983;10593924;10605720;10640428;10673366;10713152;10721994;10746781;10811134;10982388;11017109;11158588;11179968;11237011;11265639;11489943;11513152;11518510;11556966;11572855;11713259;11807247;11857637;11858820;11861603;11955593;11955595;11955599;11980922;12213321;12456660;12483297;12496264;12515809;12585966;12588680;12628924;12682293;12807887;1448173;1448174;14719373;14970179;15034010;15136729;15155468;15187158;15240572;15304001;15330449;15345499;15383545;15520807;15534202;15541655;15580655;15607800;15713743;15728350;15778510;15781451;15800062;15851719;15864273;1588291;15899827;16002701;16014749;16051604;16091383;16129954;16135789;16239428;16335952;16339513;16380601;16434485;16551255;16731529;16737824;16754661;16754721;16893496;16904340;16928187;16933105;17045824;17057721;17237375;17337780;17339034;17462920;17968485;18031695;18037897;18055229;18209062;18234675;18385332;18593354;18710925;18775695;19122653;19149696;19159218;19197368;19349973;19359216;19502598;19592130;20033473;2010551;20363321;20705068;20730098;21241660;21800138;21841309;21877119;22396535;22539938;22544926;22884367;23090970;23374253;23695528;23775590;23929856;24190977;24305946;24715725;25502872;25505266;25703557;25716998;26154972;26280087;26284469;26300885;26992070;27920218;28228285;28514659;28904123;29242379;29493099;29508533;29557506;29632711;30315122;30484775;30573663;30626607;31530632;31844290;31848261;31998317;32013031;32157095;32350084;32357974;32371447;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33912179;33968037;33999358;34211107;34357683;34405274;34433824;34509645;34561969;34932366;35051231;35154160;35318648;35580925;35849332;36241641;37074911;40307207;7505120;7517401;7525578;7531291;7541634;7542249;7542404;7559467;7685013;8118028;8178173;8325327;8344274;8459213;8560266;8777714;8798654;8838667;8910476;8995416;9251239;9268366;9285412;9298994;9314561;9443892;9565552;9660950;9700512;9730896;9858236",
        "class_list": "glycogene",
        "function": "Association of Circulating ICAM3 Concentrations with Severity and Short-term Outcomes of Acute Ischemic Stroke., [RefSeq, PubMed]; Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring apoptotic neutrophil phagocytosis by macrophages (PubMed:1448173, PubMed:1448174, PubMed:23775590, PubMed:8325327, PubMed:8459213). Is also a ligand for integrin ITGAD/ITGB2 (PubMed:8777714). Ligand of CD209 on dendritic cells (DC) through an integrin-independent mechanism that requires Ca(2+) and that forms a first contact between DC and resting T cell, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells (PubMed:10721994)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Changes in the Surface Expression of Intercellular Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells Exposed to a Random Positioning Machine. Publication Status: Online-Only, [RefSeq, PubMed]; Functional evaluation of various ICAM3 transcript variants in diffuse large B-Cell lymphoma., [RefSeq, PubMed]; The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]; Vascular injury biomarkers and stroke risk: A population-based study., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 11,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 12,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 12,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 730,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 51,
        "disease_count": 1,
        "glyco_site_count": 19,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6PD68",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0006909 phagocytosis;GO:0033631 cell-cell adhesion mediated by integrin",
        "synthesized_glycan_count": 0,
        "hit_score": 29.0,
        "record_id": "P32942-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0PJZ3-1",
        "uniprot_id": [
            {
                "id": "GXLT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0PJZ3",
                "type": "external"
            }
        ],
        "mass": 51056.0,
        "length": 443,
        "protein_name": "Glucoside xylosyltransferase 2",
        "gene_name": "GXYLT2",
        "organism": "Human",
        "refseq_name": "glucoside xylosyltransferase 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001073862",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073862",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GXYLT2; GLT8D4",
        "gene_names_refseq": "GLT8D4; GXYLT2",
        "protein_names_uniprotkb": "Glucoside xylosyltransferase 2; 2.4.2.42; Glycosyltransferase 8 domain-containing protein 4",
        "protein_names_refseq": "glucoside xylosyltransferase 2 precursor; glycosyltransferase 8 domain containing 4; glycosyltransferase 8 domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:727936);  (R-HSA-9926550)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11518510;15001579;19590037;19940119;20418909;24715725;30716301;31831667;32350084;32543734;34185709;34217213;34506251;35051231;35251023;36063796;36284347;37986328;9168821",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Glucoside xylosyltransferase 2 as a diagnostic and prognostic marker in gastric cancer via comprehensive analysis., [RefSeq, PubMed]; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose., [UniProtKB, PubMed]; MicroRNA-204-5p Hampers the Malignant Progression of Clear Cell Renal Cell Carcinoma through GXYLT2 Downregulation., [RefSeq, PubMed]; Our findings indicated that GXYLT2 plays an important role in cell activities via regulation of the Notch signaling, [RefSeq, PubMed]; Pan-cancer analysis of the prognostic significance and oncogenic role of GXYLT2., [RefSeq, PubMed]; The protein encoded by this gene is a xylosyltransferase that elongates O-linked glucose bound to epidermal growth factor (EGF) repeats. The encoded protein catalyzes the addition of xylose to the O-glucose-modified residues of EGF repeats of Notch proteins. [provided by RefSeq, Sep 2016]., [RefSeq]; We have identified two enzymes of the human glycosyltransferase 8 family, now named GXYLT1 and GXYLT2 (glucoside xylosyltransferase), as UDP-d-xylose:beta-d-glucoside alpha1,3-d-xylosyltransferases adding the first xylose., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 579,
        "reported_interactions": 0,
        "missing_score": 9781,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.4.2.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0035252 UDP-xylosyltransferase activity;GO:0140563 UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0180059 protein O-linked glycosylation via glucose",
        "synthesized_glycan_count": 7,
        "hit_score": 2.6,
        "record_id": "A0PJZ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WWY6-1",
        "uniprot_id": [
            {
                "id": "MB3L1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WWY6",
                "type": "external"
            }
        ],
        "mass": 21616.0,
        "length": 194,
        "protein_name": "Methyl-CpG-binding domain protein 3-like 1",
        "gene_name": "MBD3L1",
        "organism": "Human",
        "refseq_name": "methyl-CpG-binding domain protein 3-like 1",
        "refseq_ac": [
            {
                "id": "NP_660209",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660209",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBD3L1; MBD3L",
        "gene_names_refseq": "MBD3L1; MBD3L",
        "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 3-like 1; MBD3-like protein 1",
        "protein_names_refseq": "MBD3-like protein 1; methyl-CpG-binding domain protein 3-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85509);  (R-HSA-9937850)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "12183469;12504854;15456747;15516265;15643425;15701600;16415179;16428440;16707490;18571423;19054851;20523938;21490301;22398447;23239876;23361464;24252660;24307175;24385926;24554700;24920672;25753662;27732854;27806305;28533432;28977666;29533181;30122475;30228260;30327463;30980593;31092671;33264408;33283408;39894887;9427644;9804427;9885572",
        "class_list": "",
        "function": "Interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex, [RefSeq, PubMed]; These and other approaches identified the Nucleosome Remodeling Deacetylase (NuRD) and Chromatin Assembly Factor 1 (CAF-1) complexes as necessary for DUX4 repression in human skeletal muscle cells and induced pluripotent stem (iPS) cells.Furthermore, DUX4-induced expression of MBD3L proteins partly relieved this repression in FSHD muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2)., [RefSeq, PubMed]; This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BUM6;Q2M291",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008327 methyl-CpG binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q8WWY6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYW5-1",
        "uniprot_id": [
            {
                "id": "RN168_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYW5",
                "type": "external"
            }
        ],
        "mass": 65020.0,
        "length": 571,
        "protein_name": "E3 ubiquitin-protein ligase RNF168",
        "gene_name": "RNF168",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF168",
        "refseq_ac": [
            {
                "id": "NP_689830",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689830",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNF168",
        "gene_names_refseq": "RIDL; RNF168; hRNF168",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF168; 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168; hRNF168",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RNF168; RING-type E3 ubiquitin transferase RNF168; ring finger protein 168, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "RIDDLE syndrome (Disease Ontology:DOID:0090113)",
        "pathway": " (hsa:165918);  (R-HSA-3108214);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-69473)",
        "pathway_count": 6,
        "publication_count": 284,
        "publication_id_list": "10550055;10572166;10574707;10724175;10757784;10766245;10802669;10859164;10866324;10959836;10973490;11025670;11080452;11114888;11139606;11237011;11301010;11376695;11390408;11390642;11493912;11571274;11573085;11604075;11702069;11792325;11889051;11893489;11927591;11934988;11955432;12023295;12077346;12152085;12186630;12231622;12364621;12447390;12485996;12509254;12545175;12578958;12607003;12607005;12697768;12773400;12791985;12792649;12832489;12890688;12897153;12947387;14560035;14561766;14576433;15064416;15175327;15177042;15189136;15190204;15201865;15279782;15355988;15451442;15468306;15574327;15608651;15707391;15723659;15823533;15829507;15940266;15959518;16030353;16061182;16093244;16148040;16150728;16153896;16327781;16360315;16377563;16427009;16439204;16439205;16478998;16530042;16600297;16608850;16626738;16651405;16688858;16810316;16874298;16885023;16914548;17290226;17470781;17525332;17525340;17553757;17575048;17693435;17848578;17928296;17965729;18001824;18001825;18006705;18046455;18077395;18171670;18397950;18443292;18625722;18644861;18669648;18691969;18708356;18805091;18923075;18971343;19001859;19092802;19117993;19176521;19203578;19203579;19234442;19261749;19287951;19351884;19357644;19419957;19500350;19505854;19596686;19622798;19690332;19706679;19779455;19782031;19956565;20016594;20016603;20023648;20154705;20190268;20233725;20351172;20550933;20705237;21041483;21052091;21098080;21147198;21240188;21263215;21282113;21284855;21293379;21325134;21335604;21550342;21659603;21680713;21777809;22021381;22024395;22179609;22231403;22234877;22373579;22508508;22529269;22589545;22635276;22661229;22661230;22705371;22713238;22742833;22751501;22792074;22908299;22977173;22980979;23186163;23306437;23333306;23345434;23468639;23481700;23505375;23727112;23750026;23760478;23871147;24027577;24236237;24366607;24667604;24714562;24715725;24782567;25113031;25114211;25122754;25218447;25512557;25558984;25576301;25659039;25818648;25841101;26154972;26992070;27153538;27846572;27920218;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29393594;29403037;29493099;29508533;29557506;29786170;30315122;30410026;30429286;30524438;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33717175;33968037;34087483;34211107;34509645;34561969;34932366;35051231;35561310;35580925;36010968;36172813;36944318;37217939;37350666;37451480;37503842;38968116;39894887;8422676;8944023;9168116;9259561;9412458;9430729;9452416;9488723;9512523;9705271;9756909;9826654;9885291",
        "class_list": "",
        "function": "Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-kappaB Activation in Lupus Nephritis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RNF168 defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance., [RefSeq, PubMed]; SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer., [RefSeq, PubMed]; The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair., [RefSeq, PubMed]; This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]., [RefSeq]; UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair., [RefSeq, PubMed]; Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NA67;Q96NS4",
        "ec_number_list": [
            {
                "id": "1.14.11.69",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69",
                "type": "external"
            },
            {
                "id": "1.14.11.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.1.1.357",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.4.19.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0035861 site of double-strand break;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation",
        "synthesized_glycan_count": 0,
        "hit_score": 28.7,
        "record_id": "Q8IYW5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43080-1",
        "uniprot_id": [
            {
                "id": "GUC1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43080",
                "type": "external"
            }
        ],
        "mass": 22920.0,
        "length": 201,
        "protein_name": "Guanylyl cyclase-activating protein 1",
        "gene_name": "GUCA1A",
        "organism": "Human",
        "refseq_name": "guanylyl cyclase-activating protein 1",
        "refseq_ac": [
            {
                "id": "NP_000400",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000400",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GUCA1A; C6orf131; GCAP1; GCAP; GUCA1",
        "gene_names_refseq": "GUCA1ANB-GUCA1A",
        "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A",
        "protein_names_refseq": "guanylyl cyclase-activating protein 1",
        "tax_id": 9606,
        "disease": "cone-rod dystrophy 14 (Disease Ontology:DOID:0080314)",
        "pathway": " (hsa:118142757);  (hsa:2978);  (R-HSA-2514859)",
        "pathway_count": 3,
        "publication_count": 77,
        "publication_id_list": "10037746;10051575;10564809;10676965;11108966;11146732;11237011;11292825;11484154;11601986;11687658;11713293;11754336;12036349;12119397;12499365;12825937;1356371;1379636;1387789;1436039;14702087;15505030;15735604;15790869;15946941;16274222;16895762;16908407;17114291;17636946;18706439;18803695;19459154;19818506;1999465;20430952;20975703;22658984;24024198;24352742;2540796;2550422;2558719;26358777;28025326;28125083;28442884;29557506;3006923;30184081;30622141;3164688;31728034;31979372;32025184;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9425234;9430683;9459445;9506952;9620085",
        "class_list": "",
        "function": "Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:18706439, PubMed:19459154, PubMed:30184081, PubMed:30622141). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; This locus represents naturally occurring readthrough transcription between the neighboring GUCA1ANB (GUCA1A neighbor) and GUCA1A (guanylate cyclase activator 1A) genes on chromosome 6. The readthrough transcript encodes the same protein as GUCA1A. [provided by RefSeq, Jul 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWT4;Q7Z6T1;Q9NU14",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030249 guanylate cyclase regulator activity;GO:0008048 calcium sensitive guanylate cyclase activator activity",
        "go_cellular_component": "GO:0097381 photoreceptor disc membrane;GO:0001917 photoreceptor inner segment;GO:0120199 cone photoreceptor outer segment",
        "go_biological_process": "GO:0007165 signal transduction;GO:0031284 positive regulation of guanylate cyclase activity;GO:0071277 cellular response to calcium ion;GO:0007601 visual perception;GO:0009966 regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "P43080-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P68871-1",
        "uniprot_id": [
            {
                "id": "HBB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P68871",
                "type": "external"
            }
        ],
        "mass": 15998.0,
        "length": 147,
        "protein_name": "Hemoglobin subunit beta",
        "gene_name": "HBB",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit beta",
        "refseq_ac": [
            {
                "id": "NP_000509",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000509",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBB",
        "gene_names_refseq": "CD113t-C; ECYT6; HBB; beta-globin",
        "protein_names_uniprotkb": "Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain",
        "protein_names_refseq": "Hb Monza protein; beta globin chain; hemoglobin beta subunit; hemoglobin subunit beta; hemoglobin, beta",
        "tax_id": 9606,
        "disease": "autosomal dominant beta thalassemia (Disease Ontology:DOID:0080770); delta beta-thalassemia (Disease Ontology:DOID:0080773); sickle cell disease (Disease Ontology:DOID:0081445); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 6 (Disease Ontology:DOID:0111632); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Parkinson's disease (Disease Ontology:DOID:14330); acute chest syndrome (Disease Ontology:DOID:1584); anemia (Disease Ontology:DOID:2355); hemoglobin C disease (Disease Ontology:DOID:2859); hemoglobinopathy (Disease Ontology:DOID:2860); congenital hemolytic anemia (Disease Ontology:DOID:589); polycythemia (Disease Ontology:DOID:8432); malaria, susceptibility to (MONDO:MONDO:0021024)",
        "pathway": " (hsa:3043);  (R-HSA-1237044);  (R-HSA-1247673);  (R-HSA-2168880);  (R-HSA-6798695);  (R-HSA-9613829);  (R-HSA-9615710);  (R-HSA-9707564);  (R-HSA-9707616);  (R-HSA-983231);  (R-HSA-9927020)",
        "pathway_count": 11,
        "publication_count": 386,
        "publication_id_list": "1008494;10090333;1019344;10198158;10381560;10398311;10529219;10588683;10611283;10770934;11001883;11042108;11062261;11082038;1115799;11196644;11237011;11242053;11300344;11300351;11387216;1138922;11606574;11744692;11747442;11751636;1177322;11877257;11895428;11939514;11950885;1195378;12032298;12130498;12134158;12144064;12149194;12356737;124;12427746;12454462;12470213;1247583;12484635;12511571;1252417;12552433;12603091;12754312;12908805;12933803;12969439;1301199;1311094;13342742;13464827;13472068;13872627;13897827;1395;1487420;14958;14973;15020713;1507231;1511986;15131110;1517102;15175654;1520632;15247287;1540659;15448162;15481886;15501038;15542058;1554744;15665827;1567857;15697213;15710388;1575724;15761026;15858218;1586746;15947085;16001361;16046400;16054028;16175509;16189277;1630448;1634367;1646599;16563834;16568091;16778136;16904236;16992238;16994616;17008602;17012249;17027967;17102136;17196961;17264172;17676725;17712059;17845074;1787097;17990881;18006707;18037887;18083107;1814856;18556779;18644871;186485;18984734;19117535;1917530;1917537;1917539;19273840;19293402;19324878;19372376;19453576;19650691;19668749;19690164;19710360;1971109;19968714;20162361;20166139;20230836;20430887;20530532;20581824;20627800;2079435;20797626;20817722;20920479;20929863;20942;2101840;21041929;2111324;21238931;21282471;21479263;218813;2204156;22299025;22427940;22492620;2283301;22922649;234739;23650620;2384314;2399911;24100324;24275569;2506737;2513289;2539258;25502872;2581851;25937211;25946035;25961502;2599880;2599881;26118642;26154972;26209877;2634671;26374642;26845023;26992070;27397612;27754849;27862975;27893789;2799391;2806549;28066926;28111073;28218747;2833500;28467828;28514659;28649982;28698372;28832583;28904123;29317506;29508533;29557506;29626215;29632711;29769354;29786170;29789417;30192525;30315122;30429286;30459171;30484775;3080418;3119859;3136125;31748741;31844290;31848261;3191036;32157095;32350084;32354867;32502341;32695117;32983136;33091337;33141586;33214551;33392160;3345742;3384707;3384708;3384709;3384710;33981976;34019948;3409321;34171305;3427020;34357683;3475708;34932366;35051231;35154160;3557994;35580925;36010968;36215666;3623975;36284347;3654265;3666141;3691763;3707969;3718478;3744871;3754244;37938771;3838976;3839773;38425097;38665916;38679728;3891754;39056767;3930571;3935609;3937824;3938604;40596516;4074707;4123689;4129558;4203704;4283785;429365;4327491;4514311;4531009;4555506;4639022;4647257;4850241;4852224;496916;4975618;4994926;5135507;5656372;590504;5919752;6048303;6094553;6166590;6166632;6254664;6259091;635569;6407977;6417382;6433979;6434492;6480598;6526653;6539334;6585831;6618888;6629822;6629823;6629824;6687721;668922;6726807;6819139;6849882;6857757;7161106;7173395;721609;7238856;7263686;7287740;7338468;7338469;7338474;7358733;7373648;7378053;7541176;7693620;7918091;8070313;8111050;8144352;826083;8280608;8300612;8330972;8330974;8330979;8377203;8401300;8415693;8424694;8522332;8602627;8622974;8637569;8641705;8642597;8662539;8662638;8692836;8704193;8718692;8745430;8811317;8811319;8816476;8855948;8875343;8887638;891976;893142;8972395;9038169;9054574;9065479;9079689;9143858;9144434;9151685;9230307;9255617;9326583;9331217;9336012;9422515;9486145;9521756;971416;9761252;9830011;9843411;992050;9927674",
        "class_list": "",
        "function": "Beta[0]-Thalassemia Caused by a Novel Nonsense Mutation [HBB:c.199A > T]., [RefSeq, PubMed]; Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation., [UniProtKB]; HBB as a Novel Biomarker for the Diagnosis and Monitoring of Lung Cancer Regulates Cell Proliferation via ERK1/2 Pathway., [RefSeq, PubMed]; Includes the study of a disease-related upstream ORF in this gene, and shows that it functions to reduce protein levels by ~70%., [RefSeq, PubMed]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB, PubMed]; LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure., [UniProtKB]; Post-GWAS Validation of Target Genes Associated with HbF and HbA2 Levels. Publication Status: Online-Only, [RefSeq, PubMed]; The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 6,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 17,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4GX73;B2ZUE0;P02023;Q13852;Q14481;Q14510;Q45KT0;Q549N7;Q6FI08;Q6R7N2;Q8IZI1;Q9BX96;Q9UCD6;Q9UCP8;Q9UCP9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030492 hemoglobin binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0008217 regulation of blood pressure;GO:0042542 response to hydrogen peroxide;GO:0097746 blood vessel diameter maintenance",
        "synthesized_glycan_count": 0,
        "hit_score": 39.3,
        "record_id": "P68871-1",
        "record_type": "protein",
        "filter_code": "0000000.1010111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95528-1",
        "uniprot_id": [
            {
                "id": "GTR10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95528",
                "type": "external"
            }
        ],
        "mass": 56911.0,
        "length": 541,
        "protein_name": "Solute carrier family 2, facilitated glucose transporter member 10",
        "gene_name": "SLC2A10",
        "organism": "Human",
        "refseq_name": "solute carrier family 2, facilitated glucose transporter member 10",
        "refseq_ac": [
            {
                "id": "NP_110404",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC2A10; GLUT10",
        "gene_names_refseq": "ATORS; ATS; GLUT10; SLC2A10",
        "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 10; GLUT-10; Glucose transporter type 10",
        "protein_names_refseq": "GLUT-10; facilitative glucose transporter GLUT10; glucose transporter type 10; solute carrier family 2 (facilitated glucose transporter), member 10; solute carrier family 2, facilitated glucose transporter member 10",
        "tax_id": 9606,
        "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645)",
        "pathway": " (hsa:81031);  (R-HSA-189200);  (R-HSA-5619068)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "10821868;10860667;10970791;10987651;11133510;11237011;11245466;11247674;11425315;11583593;11592815;11681785;11741323;11780755;11832379;11994746;12504846;12590146;12801113;12885248;12941788;1415574;14569121;14614622;14739288;14997204;15033637;15607332;15902306;16051383;16154905;16550171;17050778;1756912;17635959;17935213;18063724;18327257;18565096;1918382;20616166;21107422;21940664;22212718;22521588;2656669;26650681;30429286;31844290;32157095;32938616;33592498;34561969;35051231;35413230;38219491;8457197;9354798;9751501",
        "class_list": "glycogene",
        "function": "Complex regulatory mechanism of SLC2A10 expression through interaction of multiple transcription factors on basal promotor and prescence of distal repressor sequence suggests fine modulation of GLUT10 levels critical for glucose homeostasis., [RefSeq, PubMed]; Facilitative glucose transporter required for the development of the cardiovascular system., [UniProtKB, PubMed, PubMed]; H22954, a long non-coding RNA, inhibits glucose uptake in leukemia cells in a GLUT10-dependent manner., [RefSeq, PubMed]; Revisiting the roles of glucose transporters in skeletal muscle physiology: is GLUT10 a novel player? Review article, [RefSeq, PubMed]; This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 842,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4J6;Q3MIX5;Q9H4I6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "O95528-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UMF0-1",
        "uniprot_id": [
            {
                "id": "ICAM5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UMF0",
                "type": "external"
            }
        ],
        "mass": 97116.0,
        "length": 924,
        "protein_name": "Intercellular adhesion molecule 5",
        "gene_name": "ICAM5",
        "organism": "Human",
        "refseq_name": "intercellular adhesion molecule 5 precursor",
        "refseq_ac": [
            {
                "id": "NP_003250",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003250",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICAM5; TLCN; TLN",
        "gene_names_refseq": "ICAM5; TLCN; TLN",
        "protein_names_uniprotkb": "Intercellular adhesion molecule 5; ICAM-5; Telencephalin",
        "protein_names_refseq": "ICAM-5; intercellular adhesion molecule 5 precursor; intercellular adhesion molecule 5, telencephalin; telencephalin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7087);  (R-HSA-198933);  (R-HSA-216083)",
        "pathway_count": 3,
        "publication_count": 166,
        "publication_id_list": "10.1101/2023.09.13.557529;10209034;10366422;10438935;10499918;10543983;10593924;10605720;10640428;10673366;10713152;10746781;10811134;10893271;10982388;11158588;11237011;11265639;11489943;11513152;11518510;11556966;11572855;11713259;11807247;11857637;11858820;11861603;11955593;11955595;11955599;11980922;12213321;12483297;12496264;12585966;12588680;12682293;12807887;14719373;14970179;15034010;15136729;15144186;15155468;15187158;15240572;15304001;15330449;15345499;15383545;15534202;15541655;15580655;15607800;15713743;15778510;15781451;15800062;15851719;15864273;1588291;15899827;16002701;16014749;16051604;16091383;16129954;16239428;16339513;16380601;16551255;16731529;16737824;16754661;16754721;16893496;16904340;16928187;16933105;16959974;17045824;17057721;17237375;17337780;17339034;17968485;18031695;18037897;18055229;18209062;18234675;18593354;18691975;18710925;18775695;19149696;19359216;19502598;19592130;20033473;2010551;20705068;20730098;21241660;21800138;21841309;21877119;22396535;22539938;22884367;23079714;23090970;23374253;23695528;23929856;24190977;24305946;25004970;25576301;25703557;25716998;25802875;26284469;26300885;27923705;28121444;28218747;28832583;29393594;30620550;31154438;31611695;32488085;32938616;33968037;34171305;34433824;35051231;35251023;36241641;7505120;7525578;7531291;7541634;7542249;7542404;7559467;7685013;8118028;8178173;8344274;8560266;8798654;8838667;8910476;8995416;9251239;9285412;9314561;9443892;9565552;9700512;9730896;9828136;9858236",
        "class_list": "",
        "function": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed:8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed:10893271)., [UniProtKB, PubMed, PubMed]; Here the authors identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent entry of enterovirus D68., [RefSeq, PubMed]; ICAM5 V301I and rs281439 variants may contribute to the susceptibility of breast cancer. [Meta-analysis], [RefSeq, PubMed]; The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 13,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 11,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 13,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 13,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9Y6F3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042995 cell projection;GO:0031259 uropod membrane;GO:0032591 dendritic spine membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0051289 protein homotetramerization;GO:0033631 cell-cell adhesion mediated by integrin;GO:0051963 regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 18.6,
        "record_id": "Q9UMF0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYK4-1",
        "uniprot_id": [
            {
                "id": "GT252_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYK4",
                "type": "external"
            }
        ],
        "mass": 72924.0,
        "length": 626,
        "protein_name": "Procollagen galactosyltransferase 2",
        "gene_name": "COLGALT2",
        "organism": "Human",
        "refseq_name": "procollagen galactosyltransferase 2 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001290349",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290349",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "COLGALT2; C1orf17; GLT25D2; KIAA0584",
        "gene_names_refseq": "C1orf17; COLGALT2; ColGalT 2; GLT25D2",
        "protein_names_uniprotkb": "Procollagen galactosyltransferase 2; 2.4.1.50; ColGalT 2; Collagen beta(1-O)galactosyltransferase 2; Glycosyltransferase 25 family member 2; Hydroxylysine galactosyltransferase 2",
        "protein_names_refseq": "glycosyltransferase 25 domain containing 2; glycosyltransferase 25 family member 2; hydroxylysine galactosyltransferase 2; procollagen galactosyltransferase 2 isoform 2 precursor; procollagen galactosyltransferase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23127);  (R-HSA-1650814)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10.1101/2023.09.13.557529;10479448;10934207;11237011;11318611;12473679;12475640;12646579;1323838;14500733;15044469;1577494;16591531;16959974;18487197;19075007;19693541;20470363;20546612;21878990;21967573;24190977;2543975;27397612;28832583;29242379;29557506;29741879;30192525;31611695;3173483;31844290;32157095;32350084;32387766;32488085;32938616;33392160;33592498;33760386;33783989;33968037;34509645;35051231;35251023;36538011;37074911;37208701;3905801;3938630;6307276;6809411;710450;9054364;9545296;9560306;9582318",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen., [UniProtKB, PubMed]; COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD3., [RefSeq, PubMed]; Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis., [RefSeq, PubMed]; Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk-Conferring Alleles on a Shared Target Gene, COLGALT2., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues. Publication Status: Online-Only, [RefSeq, PubMed]; Two collagen beta(1-O)galactosyltransferases corresponding to the GLT25D1 and GLT25D2 proteins were identified., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 829,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60327;Q9BZR0",
        "ec_number_list": [
            {
                "id": "2.4.1.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50",
                "type": "external"
            },
            {
                "id": "1.14.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4",
                "type": "external"
            },
            {
                "id": "2.4.1.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0030199 collagen fibril organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q8IYK4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P09105-1",
        "uniprot_id": [
            {
                "id": "HBAT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P09105",
                "type": "external"
            }
        ],
        "mass": 15508.0,
        "length": 142,
        "protein_name": "Hemoglobin subunit theta-1",
        "gene_name": "HBQ1",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit theta-1",
        "refseq_ac": [
            {
                "id": "NP_005322",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005322",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBQ1",
        "gene_names_refseq": "HBQ1; HBQ",
        "protein_names_uniprotkb": "Hemoglobin subunit theta-1; Hemoglobin theta-1 chain; Theta-1-globin",
        "protein_names_refseq": "hemoglobin subunit theta-1; hemoglobin theta-1 chain; hemoglobin, theta 1; theta-1-globin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3049)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "16728641;18491316;25548167;2569721;26154972;26992070;29557506;32350084;32938616;32983136;3408475;34171305;3422341;35051231;35251023;35580925",
        "class_list": "",
        "function": "Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13723;Q1W6G5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex",
        "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "P09105-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92729-1",
        "uniprot_id": [
            {
                "id": "PTPRU_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92729",
                "type": "external"
            }
        ],
        "mass": 162423.0,
        "length": 1446,
        "protein_name": "Receptor-type tyrosine-protein phosphatase U",
        "gene_name": "PTPRU",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase U isoform 4 precursor",
        "refseq_ac": [
            {
                "id": "NP_001181930",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181930",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRU; FMI; PCP2; PTPRO",
        "gene_names_refseq": "FMI; PCP-2; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPRU; PTPU2; PTP; R-PTP-PSI; R-PTP-U; hPTP-J",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase U; 3.1.3.48; PCP-2; PTP pi; PTP-J; PTP-RO; Pancreatic carcinoma phosphatase 2; Protein-tyrosine phosphatase J; Protein-tyrosine phosphatase pi; Protein-tyrosine phosphatase receptor omicron; R-PTP-U; R-PTP-psi; Receptor-type protein-tyrosine phosphatase psi; hPTP-J",
        "protein_names_refseq": "PTP pi; Receptor protein tyrosine phosphatase hPTP-J; pancreatic carcinoma phosphatase 2; pi R-PTP-Psi; protein-tyrosine phosphatase J; protein-tyrosine phosphatase pi; protein-tyrosine phosphatase receptor omicron; receptor-type protein-tyrosine phosphatase psi; receptor-type tyrosine-protein phosphatase U isoform 4 precursor",
        "tax_id": 9606,
        "disease": "membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrosis (Disease Ontology:DOID:2527)",
        "pathway": " (hsa:10076);  (R-HSA-1433557)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "10.1101/2023.09.13.557529;10358045;10377264;10395944;10397721;10523831;10523834;10679268;10884405;11395417;11494148;11520784;11707405;11809791;12062105;12192036;12501215;12660731;12824176;12878163;1371879;1375232;1381360;15143187;15526160;16129412;16483568;16574648;16737840;16873377;16959974;1721591;17255936;17344430;17622474;17662946;18578522;18697750;19413330;19664994;19690332;20304997;22424782;23090970;23186163;24190977;24715725;24876153;25337216;25645385;26154972;26992070;27536065;27761023;28657654;28834231;29331515;29557506;29704617;29786170;29964125;30429286;30779550;31085175;32157095;32387766;32582212;32591542;32938616;33141586;33298915;33592498;33968037;33981976;34171305;34432728;35051231;35318648;35561310;35580925;36010968;36241641;36332481;37938771;7506952;7509796;7523381;7526158;7536744;7680037;8611693;8636116;8647802;8695790;8700514;8774734;8870675;8950973;8990121;9038210;9045650;9070223;9111318;9256427;9355737;9434160;9446650;9799234;9872323",
        "class_list": "",
        "function": "High PTPRU expression is associated with glioma growth and motility., [RefSeq, PubMed]; PTPRU is required for gastric cancer cell proliferation and migration. Publication Status: Online-Only, [RefSeq, PubMed]; PTPRU, a quiescence-induced receptor tyrosine phosphatase negatively regulates osteogenic differentiation of human mesenchymal stem cells., [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]., [RefSeq]; The receptor PTPRU is a redox sensitive pseudophosphatase. Publication Status: Online-Only, [RefSeq, PubMed]; Transwell and wound-healing assays showed that miR-574-5p promotes the migration and invasion of NSCLC cells. Furthermore, miR-574-5p enhanced the tyrosine phosphorylation of beta-catenin by repressing PTPRU expression in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 7,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8L1;O00197;P78399;Q59HA4;Q5SYU4;Q5SYU5;Q92735;Q92850",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0008013 beta-catenin binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0031175 neuron projection development",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "Q92729-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PL24-1",
        "uniprot_id": [
            {
                "id": "TMED8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PL24",
                "type": "external"
            }
        ],
        "mass": 35740.0,
        "length": 325,
        "protein_name": "Protein TMED8",
        "gene_name": "TMED8",
        "organism": "Human",
        "refseq_name": "protein TMED8 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001333062",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333062",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMED8; FAM15B; L10",
        "gene_names_refseq": "FAM15B; TMED8",
        "protein_names_uniprotkb": "Protein TMED8",
        "protein_names_refseq": "family with sequence similarity 15, member B; protein TMED8 isoform c; protein TMED8; transmembrane emp24 domain containing 8; transmembrane emp24 protein transport domain containing 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283578)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "15334068;19608861;26811146;26992070;27846572;29437277;29557506;30315122;30429286;31844290;32157095;32265295;32938616;34932366",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTI6;Q3MJB0;Q9P1V9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q6PL24-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86TC9-1",
        "uniprot_id": [
            {
                "id": "MYPN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86TC9",
                "type": "external"
            }
        ],
        "mass": 145257.0,
        "length": 1320,
        "protein_name": "Myopalladin",
        "gene_name": "MYPN",
        "organism": "Human",
        "refseq_name": "myopalladin isoform a",
        "refseq_ac": [
            {
                "id": "NP_001243196",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243196",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYPN; MYOP",
        "gene_names_refseq": "CMD1DD; CMH22; CMYO24; CMYP24; MYOP; MYPN; NEM11; RCM4",
        "protein_names_uniprotkb": "Myopalladin; 145 kDa sarcomeric protein",
        "protein_names_refseq": "myopalladin isoform a; sarcomeric protein myopalladin, 145 kDa (MYOP)",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy 1KK (Disease Ontology:DOID:0110445); nemaline myopathy 11 (Disease Ontology:DOID:0110933); restrictive cardiomyopathy (Disease Ontology:DOID:397)",
        "pathway": " (hsa:84665)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "11237011;11309420;12482578;16964243;17322306;18006477;18452278;18491316;18669648;18691976;18767875;19415658;19691289;20068231;22286171;22892539;23186163;24715725;25787250;27535533;28017374;28220527;28427417;29237092;30379171;30418433;30484775;30620550;31133047;31373491;31492838;32387766;33214551;33592498;33968037;34019948;35051231;35254053;35513511;35580925;36010968;36240223;36241641;38665916;39302247;39531497;39894887;40596516",
        "class_list": "",
        "function": "A consanguineous family with congenital to adult-onset muscle weakness and hanging big toe was reported. Muscle biopsy showed minimal changes with internal nuclei, type 1 fiber predominance, and ultrastructural defects of Z line. Cardiac involvement was demonstrated by magnetic resonance imaging and late gadolinium enhancement. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines., [UniProtKB, PubMed]; Homozygous truncating mutations in MYPN in 2 unrelated families with a slowly progressive congenital cap myopathy., [RefSeq, PubMed]; Myopalladin gene is a new gene associated with dilated cardiomyopathy and observed mutations in 3-4% of cases in a population. of European descent., [RefSeq, PubMed]; Myopalladin plays a signaling role in targeting and orienting nebulin during sarcomere assembly, [RefSeq, PubMed]; Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]., [RefSeq]; Targeted sequencing revealed trigenic mutations: c.700G>A/p.E234K in DES, c.2966G>A/p.R989H in MYPN, and c.5918G>C/p.R1973P in CACNA1C in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. Erratum:[J Transl Med. 2017 May 11;15(1):101. doi: 10.1186/s12967-017-1203-y. PMID: 28490369] Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 19,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 19,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 19,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 64,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 21,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VV35;Q5VV36;Q86T37;Q8N3L4;Q96K90;Q96KF5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0008092 cytoskeletal protein binding;GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon",
        "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045214 sarcomere organization;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q86TC9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B2RTY4-1",
        "uniprot_id": [
            {
                "id": "MYO9A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B2RTY4",
                "type": "external"
            }
        ],
        "mass": 292706.0,
        "length": 2548,
        "protein_name": "Unconventional myosin-IXa",
        "gene_name": "MYO9A",
        "organism": "Human",
        "refseq_name": "unconventional myosin-IXa",
        "refseq_ac": [
            {
                "id": "NP_008832",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008832",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO9A; MYR7",
        "gene_names_refseq": "CMS24; MYO9A",
        "protein_names_uniprotkb": "Unconventional myosin-IXa; Unconventional myosin-9a",
        "protein_names_refseq": "myosin-IXa; unconventional myosin-9a; unconventional myosin-IXa",
        "tax_id": 9606,
        "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); obstructive hydrocephalus (Disease Ontology:DOID:14159); congenital myasthenic syndrome (Disease Ontology:DOID:3635); myasthenic syndrome, congenital, 24, presynaptic (MONDO:MONDO:0032597)",
        "pathway": " (hsa:4649);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013424)",
        "pathway_count": 4,
        "publication_count": 238,
        "publication_id_list": "10037681;10232922;10409426;10490598;10523665;10523675;10526156;10579713;10619026;10699171;10873388;11058585;11085924;11207612;11237011;11373293;11396949;11431473;11432776;11606631;11672528;11680691;11689693;11704860;11804589;11804590;11884391;11912491;12071859;12093360;12195014;12221077;12221096;12473120;12531887;12650940;12857875;12877655;14512443;14521508;15023524;15064355;15107133;15302923;15342493;15485661;15601624;15611138;15850391;15866170;15944396;16112081;16116428;16184169;16204458;16217026;16467373;16519628;16630611;16776779;16777452;16777849;16862148;16896804;16914516;16917499;17077126;17081983;17198702;17355222;17562871;17702745;17765681;17804252;17932950;17942708;17976533;18158243;18218625;18669648;18802007;18829452;19494238;19605563;19635168;19673492;19713215;20030946;20101212;20400958;20591975;20628200;20660154;21148482;21351730;21373644;21454492;21565175;21699497;21865595;21936715;22096251;22298643;22305756;22339630;22673745;22911862;22992742;23186163;23200924;23255595;23434736;23481700;23572525;23870313;24086303;24128008;24259668;24335996;24352656;24715725;24933155;25211221;25418920;25469497;25576301;25645385;25673874;25704760;25880248;26371245;26529257;26752647;26811146;26887924;26992070;27145964;27169898;27216196;27259756;27481945;27600516;27846572;27956608;27986909;28063628;28112683;28196833;28218747;28514659;28584191;28649982;28657654;28832583;28834231;28904123;29146911;29371260;29393594;29437277;29557506;29632046;29632711;29786170;30237576;30315122;30410026;30429286;30620550;31105010;31217245;31844290;31871319;32157095;32203420;32265295;32357974;32387766;32451867;32938616;32938750;32983136;33298915;33412162;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34185709;34509645;34561969;34932366;35051231;35580925;36010968;36241641;37938771;7479768;7673236;7721814;7753201;8021274;8022818;8537347;8543060;8571126;8617235;8643598;8649427;8662891;8756646;8769096;8807639;8810315;8816443;8939998;9013646;9111050;9113980;9305890;9418861;9490638;9497316;9535835;9548756;9659915;9670022;9778532;9792683;9819351;9822605;9829970",
        "class_list": "",
        "function": "Analysis of actin network self-organization by a monomeric myosin IXa, [RefSeq, PubMed]; Class IX Myosins: Motorized RhoGAP Signaling Molecules. Review article, [RefSeq, PubMed]; MYO9A deficiency may affect the presynaptic motor axon, manifesting in congenital myasthenic syndrome., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis., [RefSeq, PubMed]; This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]., [RefSeq]; Vaccinia virus F11 promotes viral spread by binding to host myosin-9A and inhibit RhoA signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0I1T5;C9IYB3;C9JA86;Q14787;Q3YLD7;Q3YLD8;Q6P986;Q9H8T5;Q9NTG2;Q9NUY2;Q9UEP3;Q9UNJ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0016020 membrane;GO:0045202 synapse;GO:0044295 axonal growth cone",
        "go_biological_process": "GO:0034329 cell junction assembly;GO:0035556 intracellular signal transduction;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 24.3,
        "record_id": "B2RTY4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13310-1",
        "uniprot_id": [
            {
                "id": "PABP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13310",
                "type": "external"
            }
        ],
        "mass": 70783.0,
        "length": 644,
        "protein_name": "Polyadenylate-binding protein 4",
        "gene_name": "PABPC4",
        "organism": "Human",
        "refseq_name": "polyadenylate-binding protein 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001129125",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129125",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PABPC4; APP1; PABP4",
        "gene_names_refseq": "APP-1; APP1; PABP4; PABPC4; iPABP",
        "protein_names_uniprotkb": "Polyadenylate-binding protein 4; APP-1; Activated-platelet protein 1; Inducible poly(A)-binding protein; PABP-4; Poly(A)-binding protein 4; iPABP",
        "protein_names_refseq": "PABP-4; activated-platelet protein 1; inducible poly(A)-binding protein; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; polyadenylate-binding protein 4 isoform 1; polyadenylate-binding protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8761)",
        "pathway_count": 1,
        "publication_count": 126,
        "publication_id_list": "11237011;14654843;15592455;17081983;17267499;17289661;18452278;18669648;20068231;20305658;22121020;22645359;23186163;23301498;23481700;24129315;24366607;24714562;24715725;25418920;25505266;25576301;25645385;25802875;25880248;26005159;26154972;26811146;26929215;26992070;27397612;27503676;27600516;27846572;27871484;27920218;28063628;28218747;28228285;28510447;28514659;28649982;28832583;28834231;28860189;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30059200;30315122;30379171;30397120;30429286;30484775;30524438;30620550;30779550;31154438;31217245;31373491;31492838;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33259899;33298915;33592498;33633747;33730015;33936100;33968037;33981976;34019948;34171305;34211107;34357683;34509645;34561969;34612687;34932366;35051231;35138101;35154160;35251023;35254053;35318648;35494241;35513511;35561310;35580925;35705054;36010968;36215666;36241641;36284347;37009826;37938771;38665916;38838015;39534244;40307207;40596516;40914422;41350704;8524242;9030741",
        "class_list": "",
        "function": "A novel long non-coding RNA RP11-286H15.1 represses hepatocellular carcinoma progression by promoting ubiquitination of PABPC4., [RefSeq, PubMed]; Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Binds the poly(A) tail of mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Gene variants of coagulation related proteins that interact with SARS-CoV-2. Publication Status: Online-Only, [RefSeq, PubMed]; PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy., [RefSeq, PubMed]; Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]., [RefSeq]; The PABPC4 rs4660293 SNP is associated with serum lipid levels., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ANQ8;Q4VC03;Q6P0N3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0006396 RNA processing;GO:0007596 blood coagulation;GO:0006412 translation;GO:0006401 RNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q13310-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N8D1-1",
        "uniprot_id": [
            {
                "id": "PDCD7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N8D1",
                "type": "external"
            }
        ],
        "mass": 54700.0,
        "length": 485,
        "protein_name": "Programmed cell death protein 7",
        "gene_name": "PDCD7",
        "organism": "Human",
        "refseq_name": "programmed cell death protein 7",
        "refseq_ac": [
            {
                "id": "NP_005698",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005698",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDCD7",
        "gene_names_refseq": "59K; ES18; HES18; PDCD7",
        "protein_names_uniprotkb": "Programmed cell death protein 7; ES18; hES18",
        "protein_names_refseq": "U11/U12 snRNP 59K; apoptosis-related protein ES18; programmed cell death protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10081);  (R-HSA-72165)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10037816;10207048;11237011;11333026;11607023;15146077;16096647;17940139;19052544;22617051;24714562;2524422;26375851;27510544;27846572;27862975;27920218;28228285;28832583;29242379;29971778;30340600;30524438;30555023;30779550;31154438;31530632;31844290;32157095;32488085;32502341;32897882;32938616;33298915;33592498;33633747;33849599;33968037;33981976;34087483;34171305;34211107;34561969;35051231;35561310;35580925;37938771;8835860",
        "class_list": "",
        "function": "Downregulation of both PDCD7 and E-cad and high levels miR-134 expression was observed in OSCC tumor tissues., [RefSeq, PubMed]; FIS1 and PDCD7 expression are considered independent risk factors and should be integrated into the current acute myeloid leukemia stratification system, [RefSeq, PubMed]; Polymerase acidic subunit of H9N2 polymerase complex induces cell apoptosis by binding to PDCD 7 in A549 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes apoptosis when overexpressed., [UniProtKB]; This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96AK8;Q9Y6D7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005689 U12-type spliceosomal complex",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0051384 response to glucocorticoid;GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q8N8D1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VU65-1",
        "uniprot_id": [
            {
                "id": "P210L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VU65",
                "type": "external"
            }
        ],
        "mass": 210605.0,
        "length": 1888,
        "protein_name": "Nuclear pore membrane glycoprotein 210-like",
        "gene_name": "NUP210L",
        "organism": "Human",
        "refseq_name": "nuclear pore membrane glycoprotein 210-like isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001152956",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152956",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NUP210L",
        "gene_names_refseq": "NUP210L; SPGF97",
        "protein_names_uniprotkb": "Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 kDa-like; Nucleoporin Nup210-like",
        "protein_names_refseq": "nuclear pore membrane glycoprotein 210-like (LOC91181); nuclear pore membrane glycoprotein 210-like isoform 2 precursor; nucleoporin 210kDa like; nucleoporin Nup210-like",
        "tax_id": 9606,
        "disease": "spermatogenic failure 97 (Disease Ontology:DOID:0070726)",
        "pathway": " (hsa:91181)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "10.1074/mcp.M114.046862;11237011;24715725;25813380;27846572;29557506;30379171;31020640;31844290;32488085;33332558;33392160;35051231;36215666;36241641;38129135",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 60,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EP56;Q5T4L7;Q6ZRN1;Q6ZRT4;Q6ZU81;Q8NDI6;Q9UF31",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005643 nuclear pore;GO:0031965 nuclear membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q5VU65-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05120-1",
        "uniprot_id": [
            {
                "id": "PAI2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05120",
                "type": "external"
            }
        ],
        "mass": 46596.0,
        "length": 415,
        "protein_name": "Plasminogen activator inhibitor 2",
        "gene_name": "SERPINB2",
        "organism": "Human",
        "refseq_name": "plasminogen activator inhibitor 2",
        "refseq_ac": [
            {
                "id": "NP_001137290",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137290",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SERPINB2; PAI2; PLANH2",
        "gene_names_refseq": "HsT1201; PAI-2; PAI2; PAI; PLANH2; SERPINB2",
        "protein_names_uniprotkb": "Plasminogen activator inhibitor 2; Monocyte Arg-serpin; PAI-2; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor",
        "protein_names_refseq": "monocyte Arg-serpin; placental plasminogen activator inhibitor; plasminogen activator inhibitor 2; plasminogen activator inhibitor, type II (arginine-serpin); plasminogen-activator inhibitor; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; serpin B2; serpin peptidase inhibitor, clade B (ovalbumin), member 2; urokinase inhibitor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5055);  (R-HSA-75205);  (R-HSA-8950505)",
        "pathway_count": 3,
        "publication_count": 87,
        "publication_id_list": "10368272;10391209;11237011;12007600;1286667;134998;14732874;15944288;16038020;16172807;17377532;17666018;1829461;1846368;19117638;2156852;2166055;21872626;22424782;22645359;2303256;23090970;2318848;23193360;23483454;24190977;24397554;2440681;24715725;24900876;2494165;2496749;2503541;2521625;25418920;2544876;25802875;26024233;26154972;27862975;28228285;28352266;28514659;28649982;28832583;2935528;29557506;2962641;3011081;3023326;3029122;30315122;30573663;3090045;31092671;31154438;31217245;31844290;31937595;32157095;32387766;32502341;3257578;32938616;32983136;33043033;33141586;3325828;33392160;33592498;33633747;33968037;34509645;3496414;35051231;35580925;36251494;36284347;36497110;37401942;38741146;39456691;6433976;6448849;7199524;9414276;9886297",
        "class_list": "",
        "function": "Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1., [UniProtKB]; MiR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma., [RefSeq, PubMed]; Plasminogen activator inhibitor-2 and impaired fibrinolysis in pregnancy and sickle cell anemia., [RefSeq, PubMed]; SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96E96",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001533 cornified envelope",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042730 fibrinolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.9,
        "record_id": "P05120-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96P68-1",
        "uniprot_id": [
            {
                "id": "OXGR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96P68",
                "type": "external"
            }
        ],
        "mass": 38251.0,
        "length": 337,
        "protein_name": "2-oxoglutarate receptor 1",
        "gene_name": "OXGR1",
        "organism": "Human",
        "refseq_name": "2-oxoglutarate receptor 1",
        "refseq_ac": [
            {
                "id": "NP_001333123",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333123",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OXGR1; GPR80; GPR99; P2RY15; P2Y15",
        "gene_names_refseq": "CAON2; GPR80; GPR99; OXGR1; P2RY15; P2Y15; aKGR",
        "protein_names_uniprotkb": "2-oxoglutarate receptor 1; Alpha-ketoglutarate receptor 1; G protein-coupled receptor 80; G protein-coupled receptor 99; P2Y purinoceptor 15; P2Y-like GPCR; P2Y-like nucleotide receptor; P2Y15",
        "protein_names_refseq": "2-oxoglutarate receptor 1; G protein-coupled receptor 80; G-protein coupled receptor 99; P2Y purinoceptor 15; P2Y-like GPCR; P2Y-like nucleotide receptor; alpha-ketoglutarate receptor 1; oxoglutarate (alpha-ketoglutarate) receptor 1; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); nephrolithiasis, calcium oxalate, 2, with or without nephrocalcinosis (MONDO:MONDO:0958191)",
        "pathway": " (hsa:27199);  (R-HSA-373076);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 47,
        "publication_id_list": "11007482;11237011;11574155;12044878;12098360;12120503;12522134;12524422;12955148;14617636;15001573;15141213;15280385;15326175;15929991;15951850;16540462;1656963;16634148;16754668;16844083;16923326;17139494;17339491;17462861;17876302;18434541;18577758;18588883;21796212;2263478;2534964;2748346;2834384;32104923;33121311;35580925;36571463;36919698;7498464;7568007;7689702;7775459;7937899;7946354;8015379;8406495",
        "class_list": "",
        "function": "Changes in expression of orphan receptors GPR99 and GPR107 during the development and establishment of hypertension in spontaneously hypertensive rats., [RefSeq, PubMed]; Exercise-induced alpha-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. Erratum:[EMBO J. 2021 Jul 15;40(14):e108434. doi: 10.15252/embj.2021108434. PMID: 34263469], [RefSeq, PubMed]; G protein-coupled receptor for dicarboxylates and amino dicarboxylates (PubMed:15141213, PubMed:36571463, PubMed:36919698). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity) (PubMed:15141213)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis., [RefSeq, PubMed]; P2Y15 is a cell surface receptor for AMP and adenosine, [RefSeq, PubMed]; This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T5A7;Q86TL1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045087 innate immune response;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q96P68-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E9PAV3-1",
        "uniprot_id": [
            {
                "id": "NACAM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E9PAV3",
                "type": "external"
            }
        ],
        "mass": 205422.0,
        "length": 2078,
        "protein_name": "Nascent polypeptide-associated complex subunit alpha, muscle-specific form",
        "gene_name": "NACA",
        "organism": "Human",
        "refseq_name": "nascent polypeptide-associated complex subunit alpha isoform a",
        "refseq_ac": [
            {
                "id": "NP_001106674",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106674",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NACA; HSD48",
        "gene_names_refseq": "HSD48; NAC-alpha; NACA1; NACA; skNAC",
        "protein_names_uniprotkb": "Nascent polypeptide-associated complex subunit alpha, muscle-specific form; Alpha-NAC, muscle-specific form; skNAC",
        "protein_names_refseq": "alpha-NAC, muscle-specific form; nascent polypeptide-associated complex subunit alpha isoform a; nascent-polypeptide-associated complex alpha polypeptide",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4666);  (R-HSA-9918487)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10982809;11237011;12209604;12684039;12689679;15005626;15196207;15299025;15784678;16201836;17081983;17525332;18669648;18691976;19211926;19608861;19690332;20068231;20214399;20305658;21203952;21406692;21993680;23186163;23481700;25209525;25576301;26735137;26758079;27846572;27862975;29117567;29437277;29493099;29786170;30410026;30524438;30948508;30982745;31373491;31844290;32157095;32350084;32357974;32387766;32488085;32890404;32897882;32938616;32983136;33123756;33298915;33465208;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34696522;34932366;35008409;35051231;35138101;35561310;35580925;35585045;36010968;36219563;36241641;36581221;37217939;37938771;38177122;38253038;38665916;39531497;40914422;8698236;9806765;9877153",
        "class_list": "",
        "function": "A 220 kDa isoform of Naca is expressed in mouse muscle tissues, [RefSeq, PubMed]; Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity)., [UniProtKB, UniProtKB]; Low NACA expression is associated with rhabdomyosarcoma., [RefSeq, PubMed]; NAC is a potent suppressor of aggregation and proteotoxicity of mutant PolyQ-expanded proteins associated with human diseases like Huntington's disease and spinocerebellar ataxias., [RefSeq, PubMed]; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters., [UniProtKB, PubMed, PubMed, PubMed]; The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-alpha., [RefSeq, PubMed]; These results suggest that PP1A dephosphorylates NACA at specific residues, impacting cJUN transcriptional activity and osteoblast differentiation and function., [RefSeq, PubMed]; This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 51,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 51,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 18,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 18,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 18,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 112,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 68,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0051082 unfolded protein binding;GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006612 protein targeting to membrane;GO:0043403 skeletal muscle tissue regeneration;GO:0048742 regulation of skeletal muscle fiber development;GO:0003231 cardiac ventricle development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "E9PAV3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99567-1",
        "uniprot_id": [
            {
                "id": "NUP88_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99567",
                "type": "external"
            }
        ],
        "mass": 83542.0,
        "length": 741,
        "protein_name": "Nuclear pore complex protein Nup88",
        "gene_name": "NUP88",
        "organism": "Human",
        "refseq_name": "nuclear pore complex protein Nup88 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001307582",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307582",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NUP88",
        "gene_names_refseq": "FADS4; NUP88",
        "protein_names_uniprotkb": "Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88",
        "protein_names_refseq": "karyoporin; nuclear pore complex protein 88; nuclear pore complex protein Nup88 isoform 1; nuclear pore complex protein Nup88; nucleoporin 88kDa; nucleoporin Nup88",
        "tax_id": 9606,
        "disease": "fetal akinesia deformation sequence syndrome 4 (Disease Ontology:DOID:0111379)",
        "pathway": " (hsa:4927);  (R-HSA-1169408);  (R-HSA-159227);  (R-HSA-159230);  (R-HSA-159231);  (R-HSA-159236);  (R-HSA-165054);  (R-HSA-168271);  (R-HSA-168276);  (R-HSA-168325);  (R-HSA-168333);  (R-HSA-170822);  (R-HSA-180746);  (R-HSA-180910);  (R-HSA-1855170);  (R-HSA-1855196);  (R-HSA-1855229);  (R-HSA-191859);  (R-HSA-3108214);  (R-HSA-3232142);  (R-HSA-3301854);  (R-HSA-3371453);  (R-HSA-4085377);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4615885);  (R-HSA-5619107);  (R-HSA-6784531);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9705671)",
        "pathway_count": 31,
        "publication_count": 491,
        "publication_id_list": "10205180;10228171;10323864;10444065;10489353;10526235;10531003;10556282;10574707;10601273;10601333;10668806;10725331;10759568;10827188;10846107;10851237;10862613;10920397;10954706;11014198;11073998;11095724;11112487;11118210;11124902;11157743;11231581;11237011;11256625;11259411;11259602;11289803;11333016;11451485;11455963;11502751;11514627;11579093;11709553;11714716;11727826;11739738;11747420;11748230;11756420;11788588;11792325;11836381;11871657;11889051;11909533;11932251;11960997;12003494;12019269;12027805;12032081;12065586;12072510;12093754;12095920;12121577;12138183;12149243;12196509;12228227;12393906;12441251;12525615;12526808;12582176;12589057;12692549;12711671;12729736;12747803;12759408;12776181;12802065;12832072;12853476;12857923;12917326;12974469;14516784;14578449;14627435;14701874;15082759;15109492;15120988;15131269;15161980;15175327;15199155;15208624;1531330;15317868;15355988;15364926;15378033;15485925;15574331;15592428;15608651;15702989;15731250;15802566;15823533;15829507;15831457;1586970;15931174;15940266;15959518;15989970;16009940;16030353;16112642;16122702;16139798;16140760;16194093;16278218;16314397;16352599;16361254;16407192;16428300;16478998;16608850;16608852;16626738;16688858;16699525;16710424;16715065;16775314;16810316;16815975;16872604;16914094;16933365;16964243;17000901;17018294;17081640;17081983;17132145;17183683;17204286;17224653;17289916;17317185;17322306;17376915;17412958;17525332;1754405;17690096;17693435;17698605;17705785;18203656;18226598;18235501;18235502;18287095;18305167;18364396;18381449;18394993;18408014;18411249;18423201;18452278;18535146;18550409;18583345;18625722;18628979;18669648;18691969;18691976;18708356;18767875;18809514;18946085;18984158;18991276;19073728;19125153;19229036;19270716;19287951;19413330;19415658;1944575;19494120;19562805;19596686;19622798;19640981;19651622;19664994;19664995;19682613;19690332;19691289;19706679;19779455;1985200;19914676;19956565;20016594;20016603;20068231;20098713;20112406;20129943;20133869;2017161;2017166;20190268;20219937;20300531;20305658;20308324;20351170;20385878;20417598;20630994;20663916;20705237;20797632;20797634;20953181;20972456;21098080;21136679;21147198;21167178;21209280;21284855;21300897;21311021;21335236;21406692;21450806;21526146;21550342;21554500;21559454;21593607;21647297;21690215;21740066;22121020;22174689;22223895;22402492;22424782;22457066;22464730;22465953;22493095;22508508;22541429;22544926;22635276;22661230;22732409;22735644;22751501;22825850;22893130;22898188;22940245;22941947;22944664;23092970;23186163;23299939;23301498;23349863;23481700;23582887;23750026;23804756;23826332;23871147;24002598;24027577;24068740;24366607;24369422;24397554;2470644;24714562;24715725;24782567;24870230;25114211;25218447;25391492;25418920;25505266;25576301;25640237;25645385;25704882;25723178;25849199;25880248;26154972;26375851;26572645;26728094;26811146;26929215;26992070;27068747;27397612;27501258;27600516;27846572;27920218;28063628;28228285;28415052;28832583;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30355688;30360396;30397120;30429286;30484775;30524438;30543681;30761409;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31850239;31937595;32157095;32161166;32265295;32353859;32357974;32387766;32428392;32488085;32502341;32589897;32726803;32728199;32897882;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33141586;33214551;33298915;33349665;33360543;33372174;33372854;33392160;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33633747;33691108;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34019948;34021074;34054808;34084167;34087483;34093574;34110168;34166398;34171305;34211107;34239064;34290717;34331103;34341353;34357683;34375313;34400613;34405274;34439781;34452305;34471099;34502139;34509645;34597346;34725712;34932366;35051231;35102342;35318648;35580925;35643212;36010968;36215666;36241641;36284347;37051252;37938771;38665916;40914422;41018975;6261960;6930639;7559393;7585962;7759547;7769657;7828588;7878053;7958838;8113738;8196654;8313914;8721986;8805303;8946918;9049309;9092824;9305631;9405152;9412458;9436978;9452416;9512417;9525617;9582382;9618489;9651582;9660920;9660949;9755184;9756909;9837918;9845364;9873016;9885291;9920933",
        "class_list": "",
        "function": "Component of nuclear pore complex., [UniProtKB, PubMed]; Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells., [RefSeq, PubMed]; The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTM2;Q9BWE5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017056 structural constituent of nuclear pore",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005829 cytosol",
        "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006606 protein import into nucleus;GO:0000056 ribosomal small subunit export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 49.4,
        "record_id": "Q99567-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H7X0-1",
        "uniprot_id": [
            {
                "id": "NAA60_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H7X0",
                "type": "external"
            }
        ],
        "mass": 27451.0,
        "length": 242,
        "protein_name": "N-alpha-acetyltransferase 60",
        "gene_name": "NAA60",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 60 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001077069",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077069",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA60; HAT4; NAT15; PRO7155",
        "gene_names_refseq": "HAT4; IBGC9; NAA60; NAT15; NatF; hNaa60",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; HAT4; Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F; NatF; hNaa60",
        "protein_names_refseq": "N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase 60 isoform a; N-alpha-acetyltransferase F; epididymis secretory sperm binding protein; histone acetyltransferase type B protein 4",
        "tax_id": 9606,
        "disease": "basal ganglia calcification, idiopathic, 9, autosomal recessive (MONDO:MONDO:0968977)",
        "pathway": " (hsa:79903)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;12975309;21593219;21750686;21981917;25732826;25892735;26164078;26992070;27320834;27550639;28218747;28228285;29242379;29393594;29437277;29769354;30315122;30410026;31092671;31844290;32161166;32387766;32938616;33298915;33633747;33968037;34932366;35051231;36010968;36241641;36539894;38480682",
        "class_list": "",
        "function": "Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications. Publication Status: Online-Only, [RefSeq, PubMed]; HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4], [RefSeq, PubMed]; Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity., [RefSeq, PubMed]; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826, PubMed:38480682). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27320834, PubMed:27550639). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects., [RefSeq, PubMed]; Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization., [RefSeq, PubMed]; This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 36,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KRQ0;B4DLZ0;B4DPZ8;B4DYC4;D3DUC2;E7EQ65;Q6IA31;Q6UX26",
        "ec_number_list": [
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.3.1.57",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57",
                "type": "external"
            },
            {
                "id": "2.3.1.259",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259",
                "type": "external"
            },
            {
                "id": "2.3.1.80",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0008283 cell population proliferation;GO:0006334 nucleosome assembly;GO:0006474 N-terminal protein amino acid acetylation;GO:0017196 N-terminal peptidyl-methionine acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9H7X0-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43699-1",
        "uniprot_id": [
            {
                "id": "NKX21_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43699",
                "type": "external"
            }
        ],
        "mass": 38596.0,
        "length": 371,
        "protein_name": "Homeobox protein Nkx-2.1",
        "gene_name": "NKX2-1",
        "organism": "Human",
        "refseq_name": "homeobox protein Nkx-2.1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001073136",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073136",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NKX2-1; NKX2A; TITF1; TTF1",
        "gene_names_refseq": "BCH; BHC; NK-2; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1",
        "protein_names_uniprotkb": "Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; T/EBP; TTF-1; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein",
        "protein_names_refseq": "NK-2 homolog A; homeobox protein NK-2 homolog A; homeobox protein Nkx-2.1 isoform 1; homeobox protein Nkx-2.1; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein",
        "tax_id": 9606,
        "disease": "choreatic disease (Disease Ontology:DOID:12859); papillary thyroid carcinoma (Disease Ontology:DOID:3969); brain-lung-thyroid syndrome (MONDO:MONDO:0012593)",
        "pathway": " (hsa:7080)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;11854318;11854319;11971878;15289765;15955952;19010321;19176457;20701785;24453141;24714694;26723978;26992070;30429286;31092671;31154438;31452510;31611695;32983136;34019948;35051231;35580925;36870059;36932191;37935886;38537502;38677751;7711079;7711080;7713914;9211870;9545595",
        "class_list": "",
        "function": "Diagnostic Value of Immunostaining for Thyroid Transcription Factor 1 (TTF1) and Paired Box 8 (PAX8) in Distinguishing Pulmonary Metastases of Mesonephric and Mesonephric-like Adenocarcinomas from Primary Lung Adenocarcinomas., [RefSeq, PubMed]; Functional characterization of two novel NKX2-1 frameshift variants that cause pulmonary surfactant dysfunction., [RefSeq, PubMed]; Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma., [RefSeq, PubMed]; NKX2-1 gene is targeted by H19 lncRNA and is found to be overexpressed in benign nodular goiter tissues., [RefSeq, PubMed]; This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer., [RefSeq, PubMed]; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSA3;O14954;O14955;Q7KZF6;Q9BRJ8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0030878 thyroid gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "P43699-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P41586-1",
        "uniprot_id": [
            {
                "id": "PACR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P41586",
                "type": "external"
            }
        ],
        "mass": 53314.0,
        "length": 468,
        "protein_name": "Pituitary adenylate cyclase-activating polypeptide type I receptor",
        "gene_name": "ADCYAP1R1",
        "organism": "Human",
        "refseq_name": "pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001109",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ADCYAP1R1",
        "gene_names_refseq": "ADCYAP1R1; PAC1R; PAC1; PACAPRI; PACAPR",
        "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide type I receptor; PAC1 receptor; PAC1R; PACAP type I receptor; PACAP-R-1; PACAP-R1",
        "protein_names_refseq": "PAC1 receptor; PACAP receptor 1; PACAP type I receptor; PACAP-R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; pituitary adenylate cyclase-activating polypeptide type 1 receptor; pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor",
        "tax_id": 9606,
        "disease": "cystitis (Disease Ontology:DOID:1679); post-traumatic stress disorder (Disease Ontology:DOID:2055)",
        "pathway": " (hsa:117);  (R-HSA-187024);  (R-HSA-418555);  (R-HSA-420092)",
        "pathway_count": 4,
        "publication_count": 89,
        "publication_id_list": "10322410;10583729;10698200;11007482;11060443;11237011;11946536;12036966;12058044;12106601;12180353;12860470;1333056;13549488;14671004;1517224;15464082;15471943;15765929;15769620;15951850;16313925;16687412;16805430;16923326;17168849;1739432;17470806;18044684;18577758;19105585;19876791;19929708;20381629;21036126;21625560;2163110;2417744;24687066;2491850;2553411;2553705;26417854;2826231;2871555;29443750;29602314;30833991;31154438;3127824;31279028;31399091;31983287;32004469;32047270;32226383;32497535;32540603;32618402;32715661;33049737;33715378;35051231;35409075;35477937;36385145;36430275;37074911;37543479;37894743;3899557;6085243;6192430;6745415;7589426;7680413;7700244;7811244;7851900;7902709;8144028;8340388;8390245;8514797;8672451;9263355;9417641;9651336;9990065",
        "class_list": "",
        "function": "Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research. Review article, [RefSeq, PubMed]; G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. Publication Status: Online-Only, [RefSeq, PubMed]; PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients. Publication Status: Online-Only, [RefSeq, PubMed]; Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sudden Infant Death Syndrome: A Potential Model for Investigation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 9462,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1Y1;B7ZLA7;B8ZZK3;Q17S10",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0008179 adenylate cyclase binding;GO:0017046 peptide hormone binding;GO:0031267 small GTPase binding;GO:0008528 G protein-coupled peptide receptor activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0043235 receptor complex",
        "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0006171 cAMP biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "P41586-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00254-1",
        "uniprot_id": [
            {
                "id": "PAR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00254",
                "type": "external"
            }
        ],
        "mass": 42508.0,
        "length": 374,
        "protein_name": "Proteinase-activated receptor 3",
        "gene_name": "F2RL2",
        "organism": "Human",
        "refseq_name": "proteinase-activated receptor 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243495",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243495",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "F2RL2; PAR3",
        "gene_names_refseq": "F2RL2; PAR-3; PAR3",
        "protein_names_uniprotkb": "Proteinase-activated receptor 3; Coagulation factor II receptor-like 2; PAR-3; Thrombin receptor-like 2",
        "protein_names_refseq": "Coagulation factor II receptor-like 2 (protease-actovated receptor 3); protease-activated receptor 3; proteinase-activated receptor 3 isoform 2; proteinase-activated receptor 3; thrombin receptor-like 2",
        "tax_id": 9606,
        "disease": "immunodeficiency 64 (Disease Ontology:DOID:0111980); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:2151);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-456926)",
        "pathway_count": 4,
        "publication_count": 139,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16102047;16182515;16268778;16339447;16458856;1655761;16580177;1672265;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;19715408;20670195;23446738;23690594;24906252;25320242;25576301;25892735;2649896;26729042;26742564;27496565;27846572;2841328;3086311;3202875;32639031;32938616;3366244;33968037;35051231;3525564;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8290554;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;8982657;9087410;9171878;9305846;9521323;9530155;9593744;9607765;9614115;9618465;9685625;9722565;9770463;9792798;9832121;9851594;9924018",
        "class_list": "",
        "function": "PAR3 is essential in thrombin stimulated insulin secretion., [RefSeq, PubMed]; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis., [UniProtKB, PubMed]; TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production., [RefSeq, PubMed]; These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR activation, such as the activation of vascular-protective Tie2 by noncanonical PAR3 activation., [RefSeq, PubMed]; This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R754;B4DQ13;Q52M68;Q7Z3W3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004930 G protein-coupled receptor activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007596 blood coagulation;GO:0009611 response to wounding;GO:0030168 platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "O00254-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12923-1",
        "uniprot_id": [
            {
                "id": "PTN13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12923",
                "type": "external"
            }
        ],
        "mass": 276906.0,
        "length": 2485,
        "protein_name": "Tyrosine-protein phosphatase non-receptor type 13",
        "gene_name": "PTPN13",
        "organism": "Human",
        "refseq_name": "tyrosine-protein phosphatase non-receptor type 13 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_006255",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006255",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPN13; PNP1; PTP1E; PTPL1",
        "gene_names_refseq": "FAP-1; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE; PTPN13; hPTP1E",
        "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 13; 3.1.3.48; FAP-1; Fas-associated protein-tyrosine phosphatase 1; PTP-BAS; PTP-E1; Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; hPTPE1",
        "protein_names_refseq": "fas-associated protein-tyrosine phosphatase 1; hPTPE1; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); protein-tyrosine phosphatase 1E; protein-tyrosine phosphatase PTPL1; tyrosine-protein phosphatase non-receptor type 13 isoform 2",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:5783);  (R-HSA-1660499);  (R-HSA-9008059);  (R-HSA-9696264);  (R-HSA-9696270);  (R-HSA-9696273)",
        "pathway_count": 6,
        "publication_count": 193,
        "publication_id_list": "10194451;10224048;10400701;10544233;10555148;10559940;10593988;10664463;10704206;10753883;10805725;10822173;10826496;11001876;11084340;11145836;11237011;11279162;11302699;11349134;11356191;11604140;11676921;11733541;11784792;11839743;11877430;11923287;11940653;12095257;12096920;12101241;12118066;12244061;12324459;12381835;12422219;12436199;12536145;12646134;12808147;12809600;12842009;12847086;14516276;14617813;14660569;14732713;15080793;15107860;15135396;15464023;15527767;15611135;15716355;15738000;15797027;15840652;16154996;16399794;16476736;16481321;16522682;16914545;16979564;17008356;17245604;17651088;18093523;18390730;18452278;18753295;18996843;19038970;19103606;19136556;19307596;19413330;19664994;19664995;19672627;19892796;19896968;20534812;20811643;20935647;21204784;21406692;22037487;22424782;22647598;23108400;23186163;23481700;23519112;23604317;23758345;24366607;24481253;24690281;25495341;25576301;25645385;25729923;25888806;26154972;26969432;26992070;27060871;27920218;28063628;28092676;28218747;28228285;28504867;28514659;28832583;28904123;29237092;29242379;29393594;29437277;29557506;29632046;29769354;29786170;30315122;30410026;30429286;30779550;31154438;31217245;31530632;31844290;31848261;31871319;31937595;32157095;32161166;32265295;32357974;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33912179;33968037;34087483;34185709;34211107;34509645;34561969;34932366;35051231;35580925;36010968;36193770;36241641;37938771;38039548;38967523;39302247;7536343;7608176;7624799;7929060;8071359;8287977;8483328;8649376;8681945;8723348;8769125;9094719;9113989;9211928;9286278;9295334;9305890;9367159;9428629;9514948;9516481;9524259;9531558;9593664;9660759;9660833;9811831;9830063",
        "class_list": "",
        "function": "METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression., [RefSeq, PubMed]; PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer., [RefSeq, PubMed]; Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling., [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]., [RefSeq]; Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTR0;Q15159;Q15263;Q15264;Q15265;Q15674;Q16826;Q8IWH7;Q9NYN9;Q9UDA8",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.4.17.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22",
                "type": "external"
            },
            {
                "id": "2.7.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "1.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3",
                "type": "external"
            },
            {
                "id": "1.2.1.94",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0001933 negative regulation of protein phosphorylation;GO:0097237 cellular response to toxic substance;GO:0006470 protein dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 19.7,
        "record_id": "Q12923-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13950-1",
        "uniprot_id": [
            {
                "id": "RUNX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13950",
                "type": "external"
            }
        ],
        "mass": 56648.0,
        "length": 521,
        "protein_name": "Runt-related transcription factor 2",
        "gene_name": "RUNX2",
        "organism": "Human",
        "refseq_name": "runt-related transcription factor 2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001015051",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015051",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RUNX2; AML3; CBFA1; OSF2; PEBP2A",
        "gene_names_refseq": "AML3; CBF-alpha-1; CBFA1; CCD1; CCD; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA; RUNX2",
        "protein_names_uniprotkb": "Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; CBF-alpha-1; Core-binding factor subunit alpha-1; OSF-2; Oncogene AML-3; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEBP2-alpha A; Polyomavirus enhancer-binding protein 2 alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit",
        "protein_names_refseq": "PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; acute myeloid leukemia 3 protein; core-binding factor, runt domain, alpha subunit 1; oncogene AML-3; osteoblast-specific transcription factor 2; polyomavirus enhancer-binding protein 2 alpha A subunit; runt related transcription factor 2; runt-related transcription factor 2 isoform b",
        "tax_id": 9606,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); metabolic acidosis (Disease Ontology:DOID:0050758); glucocorticoid-induced osteoporosis (Disease Ontology:DOID:0060343); metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome (Disease Ontology:DOID:0111513); osteonecrosis (Disease Ontology:DOID:10159); osteoporosis (Disease Ontology:DOID:11476); cleidocranial dysplasia (Disease Ontology:DOID:13994); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:860)",
        "pathway_count": 1,
        "publication_count": 90,
        "publication_id_list": "10521292;10545612;10689183;10980549;11237011;11857736;11965546;12081718;12145306;12196916;12231506;12424590;16270353;16299379;16407259;16613857;17377532;17707335;18220336;19744171;19801668;20082269;20648631;23290074;23481700;24984680;25187572;25892735;26154972;26811146;26992070;27920218;28063628;28228285;28505335;28703881;28738062;28832583;28904123;29050333;29242379;29315243;29393594;29493099;29557506;29632046;29786170;29988028;30315122;30524438;31154438;31217245;31530632;31779679;31844290;31848261;31998317;32157095;32161166;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33298915;33968037;34019948;34357683;34509645;34561969;35051231;35254053;35318648;35580925;36010968;36241641;36284347;36861967;38665916;39000419;39271656;39337587;40596516;9182765;9207800;9233771;9434946;9651525",
        "class_list": "",
        "function": "Exploring the transcriptional cooperation between RUNX2 and its associated elncRNA RAIN. Publication Status: Online-Only, [RefSeq, PubMed]; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB]; Hypomethylation of the RUNX2 Gene Is a New Potential Biomarker of Primary Osteoporosis in Men and Women. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of Skeletal Development and Maintenance by Runx2 and Sp7. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]., [RefSeq]; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062, PubMed:16299379). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14614;O14615;O95181",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q13950-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N387-1",
        "uniprot_id": [
            {
                "id": "MUC15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N387",
                "type": "external"
            }
        ],
        "mass": 36294.0,
        "length": 334,
        "protein_name": "Mucin-15",
        "gene_name": "MUC15",
        "organism": "Human",
        "refseq_name": "mucin-15 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001128563",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128563",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC15; PRO1481",
        "gene_names_refseq": "MUC-15; MUC15; PAS3; PASIII",
        "protein_names_uniprotkb": "Mucin-15; MUC-15",
        "protein_names_refseq": "mucin-15 isoform a; mucin-15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:143662);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 69,
        "publication_id_list": "10330415;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11606584;11821425;12047385;12464682;12855678;12975309;1329093;14656219;15466199;15486459;15560372;15599692;15620693;15687324;16151858;16251947;16319059;17050534;17113861;17720698;18490740;18537974;18776906;18818202;18834073;19520792;19617566;21880719;22041900;22183981;22461326;23053572;23507963;23602766;2373995;24643043;25153226;31844290;32157095;33051432;33392160;33894313;35236826;35580925;37531748;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia., [RefSeq, PubMed]; Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]; MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3beta/beta-catenin signaling., [RefSeq, PubMed]; MUC15 was expressed most highly in human placenta. MUC15 mRNA & protein increased with gestational age (P < 0.05, 1st versus 3rd trimester). Differential expression of MUC15 in human placentas may play critical role in regulation of trophoblast invasion., [RefSeq, PubMed]; May play a role in the cell adhesion to the extracellular matrix., [UniProtKB]; Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of colon cancer cells., [RefSeq, PubMed]; Reflux laryngitis is associated with down-regulation of mucin gene expression., [RefSeq, PubMed]",
        "predicted_glycosites": 10,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KY00;E9PII6;F8W945;Q6UWS3;Q8IXI8;Q8WW41",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q8N387-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15080-1",
        "uniprot_id": [
            {
                "id": "NCF4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15080",
                "type": "external"
            }
        ],
        "mass": 39032.0,
        "length": 339,
        "protein_name": "Neutrophil cytosol factor 4",
        "gene_name": "NCF4",
        "organism": "Human",
        "refseq_name": "neutrophil cytosol factor 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000622",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000622",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCF4; SH3PXD4",
        "gene_names_refseq": "CGD3; NCF4; NCF; P40PHOX; SH3PXD4",
        "protein_names_uniprotkb": "Neutrophil cytosol factor 4; NCF-4; Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phox",
        "protein_names_refseq": "NCF-4; SH3 and PX domain-containing protein 4; neutrophil NADPH oxidase factor 4; neutrophil cytosol factor 4 isoform 1; neutrophil cytosol factor 4; neutrophil cytosolic factor 4, 40kDa; p40-phox",
        "tax_id": 9606,
        "disease": "autosomal recessive chronic granulomatous disease 3 (Disease Ontology:DOID:0070194); rheumatoid arthritis (Disease Ontology:DOID:7148)",
        "pathway": " (hsa:4689);  (R-HSA-1222556);  (R-HSA-1236973);  (R-HSA-3299685);  (R-HSA-4420097);  (R-HSA-5668599);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013423)",
        "pathway_count": 9,
        "publication_count": 457,
        "publication_id_list": "10029572;10037737;10072071;10075701;10207622;10232922;10358769;10395673;10400704;10437784;10455184;10464238;10490598;10508610;10514471;10521424;10523665;10523675;10526156;10559246;10579713;10618392;10656833;10677529;10692392;10699171;10699464;10744763;10749680;10833429;10847683;10873802;10919671;10958683;10982;11007481;11018045;11058585;11085924;11090627;11139407;11145705;11149925;11237011;11237855;11278486;11373293;11396949;11431473;11432776;11507097;11518528;11584276;11672528;11684018;11695992;11696015;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11886899;11912491;11912930;11919634;11956649;11961559;11970843;12056906;12071859;12093360;12096337;12134158;12195014;12214271;12215529;12221096;12351724;12391143;12432077;12446202;12464388;12531887;12546821;12547822;12650940;12660731;12665586;12716910;12810700;12820653;12829378;12857875;12877655;12887891;12923183;14512443;14514689;14530365;1464587;14675773;14718541;14724572;15023524;15026417;15033976;15044467;15046979;15064355;15064408;15107133;15133129;15147912;15169870;15247219;15280035;15302923;15308668;15317809;15339924;15342493;15485661;15507211;15542837;15579468;15591124;15596429;15601624;15611138;15657040;15688067;15695828;15728722;15814684;15824103;15850391;15858067;15897194;15927447;15962004;16002401;16081809;16112081;16116428;16184169;16243035;16243036;16329988;16336962;16401067;16473593;16492808;16507994;16519628;1660188;16615992;16636067;1668270;16702231;16750198;16760434;16762923;16777452;16777849;16778989;16862148;16880213;16896804;16914516;16966330;16968698;17030947;17060455;17077126;17145773;17158234;17196961;17199126;17214551;17237347;17244649;17269730;17275676;17290225;17293873;17351642;17519234;17583407;17599059;1763037;17662945;17686471;17698854;17702745;17707404;17765681;17804252;17976533;18006505;18045877;18056264;18191593;18218625;18249095;18268517;18331591;18347018;18358825;18396277;18426980;18477386;18653540;18662984;18682599;18697831;18703498;18838382;18936159;19089323;19217269;19219623;19230644;19267251;19269969;19372727;19494238;19534724;19542232;19605563;19673492;19692703;19713215;19934221;1999334;20070187;20134026;20171863;20367259;20400958;20460433;20658524;20679435;20690882;2071038;20810653;20813901;20956805;21124855;21148482;21151158;21215271;21239714;21378159;21385867;21393238;21445309;21542010;21565175;21613211;21730051;21850230;21865595;21967640;21989057;22004470;22096251;22298643;22327215;22407364;22475431;22493009;22608513;22689825;22734669;22808130;22869735;22910329;22970203;23152058;23164639;23209303;23216836;23255595;23288169;23289851;23434736;23454490;23455484;23481700;23572525;23707487;23718289;23757206;23870057;23875749;23940355;23980663;24086303;24259668;24335996;24352656;24623723;24714562;24715725;24859002;24933155;24960694;25024229;25047527;25211221;25428919;25505266;25704760;25721503;25795300;25862245;25877926;26016997;26129894;26375851;26529257;26628301;26728094;26887924;26992070;27117132;27145964;27216196;27481945;27555588;27558335;27566826;27713499;27806292;27846572;27862975;28114311;28196833;2825632;28356423;2848506;28904123;29089502;29358323;29382922;29437277;29493099;29557506;30315122;30379171;30429286;30524438;30853411;31154438;31389670;31844290;31848261;31871319;31937595;32203420;32357974;32387766;32502341;32897882;32983136;33145364;33633747;33691108;33912179;34357683;34561969;3457020;34708124;35051231;3532102;35561310;35580925;3619451;3693360;38085396;38886341;5389100;60;6286671;6961438;7021796;7172448;7479768;7487923;7509446;7512369;7559638;7673236;7678924;7721814;7753201;7835339;7980580;8021274;807573;8089108;8107774;8280052;8379940;8428933;8452552;8537108;8537347;8543060;8617235;8643598;8645157;8662891;8663465;8756646;8769096;8798539;8805223;8810315;8816443;8839867;8939998;8986718;8990121;8994827;9013646;9099726;9113980;9182576;9252344;9295278;9305890;9369223;9393975;9398617;9438849;9472046;9490638;9497316;9582072;9639555;9659915;9670022;9705280;9726962;9763615;9792683;9804763;9822598;9843499;9923614;9988689",
        "class_list": "",
        "function": "Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population. Publication Status: Online-Only, [RefSeq, PubMed]; NCF1/2/4 Are Prognostic Biomarkers Related to the Immune Infiltration of Kidney Renal Clear Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance. Publication Status: Online-Only, [RefSeq, PubMed]; Polymorphisms of the NCF4 Gene Increase the Risk of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus., [RefSeq, PubMed]; Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (Probable). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (By similarity). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4F9;O60808;Q86U56;Q9BU98;Q9NP45",
        "ec_number_list": [],
        "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0016176 superoxide-generating NADPH oxidase activator activity;GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006909 phagocytosis;GO:0045730 respiratory burst;GO:0042554 superoxide anion generation",
        "synthesized_glycan_count": 0,
        "hit_score": 46.0,
        "record_id": "Q15080-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NPC7-1",
        "uniprot_id": [
            {
                "id": "MYNN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NPC7",
                "type": "external"
            }
        ],
        "mass": 68682.0,
        "length": 610,
        "protein_name": "Myoneurin",
        "gene_name": "MYNN",
        "organism": "Human",
        "refseq_name": "myoneurin isoform A",
        "refseq_ac": [
            {
                "id": "NP_001172047",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001172047",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYNN; OSZF; SBBIZ1; ZBTB31",
        "gene_names_refseq": "MYNN; OSZF; SBBIZ1; ZBTB31; ZNF902",
        "protein_names_uniprotkb": "Myoneurin; Zinc finger and BTB domain-containing protein 31",
        "protein_names_refseq": "myoneurin isoform A; zinc finger and BTB domain-containing protein 31; zinc finger protein with BTB/POZ domain",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55892)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "10873615;11237011;14694499;18676680;19690332;19692168;20068231;23186163;24715725;25576301;25880248;26154972;26375851;26992070;27846572;27862975;27920218;28218747;28446606;28834231;28904123;29242379;29393594;29437277;30120764;30315122;30429286;31092671;31844290;31848261;31937595;32157095;32161166;32897882;33141586;33298915;33592498;33912179;33981976;38165846",
        "class_list": "",
        "function": "Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; There may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6C9;Q6QHA6;Q6QHA7;Q6R3G1;Q6R3G2;Q6R4A0;Q7Z716;Q7Z717;Q86Z11;Q86Z12;Q9NS01;Q9UIW8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q9NPC7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N6T7-1",
        "uniprot_id": [
            {
                "id": "SIR6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N6T7",
                "type": "external"
            }
        ],
        "mass": 39119.0,
        "length": 355,
        "protein_name": "NAD-dependent protein deacylase sirtuin-6",
        "gene_name": "SIRT6",
        "organism": "Human",
        "refseq_name": "NAD-dependent protein deacylase sirtuin-6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180214",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180214",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SIRT6; SIR2L6",
        "gene_names_refseq": "SIR2L6; SIRT6; hSIRT6",
        "protein_names_uniprotkb": "NAD-dependent protein deacylase sirtuin-6; 2.3.1.-; 2.3.1.286; 2.4.2.-; NAD-dependent protein deacetylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; hSIRT6",
        "protein_names_refseq": "NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6 isoform 2; NAD-dependent protein deacylase sirtuin-6; SIR2-like protein 6; protein mono-ADP-ribosyltransferase sirtuin-6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); transient cerebral ischemia (Disease Ontology:DOID:224); progeria (Disease Ontology:DOID:3911); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:51548);  (R-HSA-1912408);  (R-HSA-5685939);  (R-HSA-5693607)",
        "pathway_count": 4,
        "publication_count": 190,
        "publication_id_list": "10859164;10873683;11080452;11139606;11237011;11301010;11340072;11376695;11390642;11440997;12152085;12545175;12578958;12791985;14576433;14991602;15135726;15189136;15190204;15472075;15561706;15684396;15707391;16012167;16079181;16148040;16153896;16327781;16360315;16530042;16612405;16885023;17344417;17540598;17540599;17554337;17575048;17685488;17823410;17928296;17965729;18171670;1831692;18337721;18669648;18805091;18923075;18971343;19135889;19150886;19357644;19419957;19625767;19714243;19723635;19773441;20080834;20090754;20154705;20233725;20351093;20442293;20442780;20483915;20495621;20647759;20801121;20805998;20829486;21052091;21240188;21263215;21280156;21325134;21335604;21362626;21402699;21551231;21602795;21659603;21680713;21680843;21777809;21816818;21847107;21875955;22021381;22024395;22110129;22231403;22635276;22661229;22661230;22753495;22792074;22977173;23142079;23186163;23217706;23345434;23468639;23552949;23653361;23892288;23911928;24012758;24043303;24052263;24163442;24275569;25009184;25074979;25113031;25122754;25201414;25541994;25558984;25642960;25642963;25643323;25659039;25789972;25915124;26456828;26748705;26787900;26898756;26977885;26992070;27043296;27180906;27322069;27568560;27846572;27912097;27920218;27990725;28228285;28406396;28832583;28904123;29101237;29133916;29393594;29474172;29493099;29555651;29557506;30315122;30374165;30395713;30504065;30518851;30833945;31844103;31844290;31848261;31995034;32387766;32502341;32538779;32789493;32897882;32938616;32983136;33067423;33122195;33214841;33298915;33649599;33649600;33936100;34211107;34359939;34616022;34932366;35051231;35580925;36172813;37023208;38967361;38986922;39033117;39183280;39259343;8003475;8878478;9214649;9693032;9705271",
        "class_list": "",
        "function": "Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant. Publication Status: Online-Only, [RefSeq, PubMed]; NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626, PubMed:21680843, PubMed:23217706, PubMed:23552949, PubMed:23653361, PubMed:24052263, PubMed:27180906, PubMed:27322069, PubMed:29555651, PubMed:30374165). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (PubMed:23552949, PubMed:24052263, PubMed:27322069). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:19625767, PubMed:21362626, PubMed:23892288, PubMed:23911928, PubMed:24012758, PubMed:26456828, PubMed:26898756, PubMed:27043296, PubMed:27180906, PubMed:30374165, PubMed:33067423). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (By similarity). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (PubMed:23911928, PubMed:31995034, PubMed:32538779). SIRT6 participation to DSB repair is probably involved in extension of life span (By similarity). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (PubMed:29474172, PubMed:32789493). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (PubMed:27043296). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (PubMed:18337721, PubMed:19625767, PubMed:21847107). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (PubMed:25915124, PubMed:29555651). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (PubMed:24012758, PubMed:26787900). Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (By similarity). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect (PubMed:23217706). Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) (PubMed:26787900). Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 (PubMed:23142079, PubMed:25009184). Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (By similarity). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non-histone proteins, such as FOXO1 (By similarity). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (By similarity). The defatty-acylase activity is specifically involved in regulation of protein secretion (PubMed:23552949, PubMed:24052263, PubMed:27322069, PubMed:28406396). Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion (PubMed:23552949, PubMed:28406396). Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 (PubMed:21680843, PubMed:22753495, PubMed:27322069, PubMed:27568560). Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription (PubMed:21680843, PubMed:22753495, PubMed:27568560)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SIRT6 alleviates senescence induced by Porphyromonas gingivalis in human gingival fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating Survivin., [RefSeq, PubMed]; This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]., [RefSeq]; X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 25,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCD0;O75291;Q6IAF5;Q6PK99;Q8NCD2;Q9BSI5;Q9BWP3;Q9NRC7;Q9UQD1",
        "ec_number_list": [
            {
                "id": "2.4.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31",
                "type": "external"
            },
            {
                "id": "2.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.286",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0000785 chromatin;GO:0035861 site of double-strand break",
        "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0031508 pericentric heterochromatin formation;GO:2000648 positive regulation of stem cell proliferation;GO:1902459 positive regulation of stem cell population maintenance;GO:1905564 positive regulation of vascular endothelial cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "Q8N6T7-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N2R0-1",
        "uniprot_id": [
            {
                "id": "OSR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N2R0",
                "type": "external"
            }
        ],
        "mass": 35513.0,
        "length": 312,
        "protein_name": "Protein odd-skipped-related 2",
        "gene_name": "OSR2",
        "organism": "Human",
        "refseq_name": "protein odd-skipped-related 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001135934",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135934",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OSR2",
        "gene_names_refseq": "OSR2",
        "protein_names_uniprotkb": "Protein odd-skipped-related 2",
        "protein_names_refseq": "odd-skipped related 2; protein odd-skipped-related 2 isoform a; protein odd-skipped-related 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116039)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;20634891;23481700;24715725;27143812;28832583;28904123;29242379;29786170;30429286;31217245;31844290;33711044;33912179;35051231;38744281",
        "class_list": "",
        "function": "A comprehensive molecular characterization of the 8q22.2 region reveals the prognostic relevance of OSR2 mRNA in muscle invasive bladder cancer. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the development of the mandibular molar tooth germ at the bud stage., [UniProtKB, UniProtKB]; OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Osr2 functions as a biomechanical checkpoint to aggravate CD8[+] T cell exhaustion in tumor., [RefSeq, PubMed]; Results found that OSR2, VAV3, and PPFIA3 were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K626;B4E3B7;Q96AM6;Q96LB6;Q96LB7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0033687 osteoblast proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q8N2R0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IN85-1",
        "uniprot_id": [
            {
                "id": "P4R3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IN85",
                "type": "external"
            }
        ],
        "mass": 95368.0,
        "length": 833,
        "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 3A",
        "gene_name": "PPP4R3A",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001271209",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271209",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP4R3A; KIAA2010; MSTP033; PP4R3A; SMEK1",
        "gene_names_refseq": "FLFL1; KIAA2010; MSTP033; PP4R3A; PP4R3; PPP4R3A; SMEK1; smk-1; smk1",
        "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 3A; SMEK homolog 1",
        "protein_names_refseq": "SMEK homolog 1, suppressor of mek1; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1; serine/threonine-protein phosphatase 4 regulatory subunit 3A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55671)",
        "pathway_count": 1,
        "publication_count": 66,
        "publication_id_list": "11237011;16085932;18487071;18614045;18669648;19608861;19690332;21406692;22544926;22645359;23186163;24275569;24715725;25576301;25880248;26154972;26811146;26992070;27846572;28510447;28904123;29130521;29242379;29437277;29493099;29557506;30429286;30484775;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33691108;33717175;33936100;33968037;34019948;34087483;34171305;34185709;34211107;34405274;34509645;35008409;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36731689;37938771;38838857;40914422",
        "class_list": "",
        "function": "A variant in PPP4R3A was associated with reduced metabolic decline in Alzheimer's disease patients., [RefSeq, PubMed]; New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate., [RefSeq, PubMed]; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair., [UniProtKB, PubMed]; Tumour suppressor protein sMEK1 links to IRE1 signalling pathway to modulate its activity during ER stress., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q69YK6;Q86U23;Q86YI7;Q8IVG1;Q9H3F1;Q9H7U8;Q9NV01;Q9NWP1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0072542 protein phosphatase activator activity;GO:0019888 protein phosphatase regulator activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030289 protein phosphatase 4 complex",
        "go_biological_process": "GO:0006974 DNA damage response;GO:2000779 regulation of double-strand break repair",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q6IN85-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P59045-1",
        "uniprot_id": [
            {
                "id": "NAL11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P59045",
                "type": "external"
            }
        ],
        "mass": 117779.0,
        "length": 1033,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 11",
        "gene_name": "NLRP11",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 11 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001284672",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284672",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP11; NALP11; NOD17; PAN10; PYPAF6",
        "gene_names_refseq": "CLR19.6; NALP11; NLRP11; NOD17; PAN10; PYPAF6; PYPAF7",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 11; Nucleotide-binding oligomerization domain protein 17; PAAD-and NACHT domain-containing protein 10; PYRIN-containing APAF1-like protein 6",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 11 isoform 2; NACHT, LRR and PYD domains-containing protein 11; NACHT, leucine rich repeat and PYD containing 11; PAAD- and NACHT-containing protein 10B; PAAD-and NACHT domain-containing protein 10; PYRIN-containing APAF1-like protein 6; nucleotide-binding oligomerization domain protein 17; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:204801)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;12019269;12563287;12615073;23481700;24715725;25418920;25505266;25576301;25802875;25892735;26154972;26992070;27846572;27920218;28228285;28904123;29097393;29242379;29301940;29557506;30315122;31844290;31937595;31998317;32357974;32832566;33141586;33298915;34105348;35051231;37217939;37478192",
        "class_list": "",
        "function": "Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4(+) T Helper Cell Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that NLRP11 plays novel role in myeloid cells and B-lymphocytes (where NLRP11 expression is high); expression of NLRP11 in both tumor and non-tumor cell lines down-regulates NFkappaB and interferon type I signaling responses., [RefSeq, PubMed]; Involved in inflammation., [UniProtKB]; NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages., [RefSeq, PubMed]; This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]., [RefSeq]; Using MAVS as a platform, NLRP11 degrades TRAF6 to attenuate the production of type I IFNs as well as virus-induced apoptosis. Our findings reveal the regulatory role of NLRP11 in antiviral immunity by disrupting MAVS signalosome., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JSF5;Q2TV85;Q2TV86;Q53ZZ0;Q8NBF5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "P59045-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14513-1",
        "uniprot_id": [
            {
                "id": "NCKP5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14513",
                "type": "external"
            }
        ],
        "mass": 208537.0,
        "length": 1909,
        "protein_name": "Nck-associated protein 5",
        "gene_name": "NCKAP5",
        "organism": "Human",
        "refseq_name": "nck-associated protein 5 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_997246",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997246",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCKAP5; ERIH; NAP5",
        "gene_names_refseq": "ERIH1; ERIH2; NAP5; NCKAP5",
        "protein_names_uniprotkb": "Nck-associated protein 5; NAP-5; Peripheral clock protein",
        "protein_names_refseq": "NAP-5; nck-associated protein 5 isoform 1; nck-associated protein 5; peripheral clock protein 2",
        "tax_id": 9606,
        "disease": "proteinuria (Disease Ontology:DOID:576)",
        "pathway": " (hsa:344148)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;19488044;20068231;23345538;24714562;26154972;29351928;30379171;30524438;32157095;32387766;32938616;34211107;35051231;36010968;37217939;38253038;9344857",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 75,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZL0;Q29SS9;Q29ST0;Q2NL90;Q6ZVE2;Q8NAS3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0035371 microtubule plus-end",
        "go_biological_process": "GO:0007019 microtubule depolymerization;GO:0001578 microtubule bundle formation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O14513-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BY77-1",
        "uniprot_id": [
            {
                "id": "PDIP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BY77",
                "type": "external"
            }
        ],
        "mass": 46089.0,
        "length": 421,
        "protein_name": "Polymerase delta-interacting protein 3",
        "gene_name": "POLDIP3",
        "organism": "Human",
        "refseq_name": "polymerase delta-interacting protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_115687",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115687",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POLDIP3; KIAA1649; PDIP46",
        "gene_names_refseq": "PDIP3; PDIP46; POLDIP3; SKAR",
        "protein_names_uniprotkb": "Polymerase delta-interacting protein 3; 46 kDa DNA polymerase delta interaction protein; S6K1 Aly/REF-like target; SKAR; p46",
        "protein_names_refseq": "46 kDa DNA polymerase delta interaction protein; RNA-binding protein P46; S6K1 Aly/REF-like target; polymerase (DNA) delta interacting protein 3; polymerase (DNA-directed), delta interacting protein 3; polymerase delta-interacting protein 3 isoform 1; polymerase delta-interacting protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84271);  (R-HSA-159236);  (R-HSA-72187)",
        "pathway_count": 3,
        "publication_count": 139,
        "publication_id_list": "10228171;10323864;10489353;10668806;11073998;11237011;11256625;11258795;11259411;11259602;11579093;11739738;11756420;11979277;12093754;12522211;12871933;15341740;15998806;16314397;16984396;17000901;17190602;17525332;17924679;17984224;18364396;18411249;18423201;18477386;18669648;18957205;19690332;19836239;20068231;20129943;20573985;20844015;21947206;22207203;22223895;22645359;22893130;22928037;23186163;23222130;23299939;23481700;23826332;24129315;24244187;24715725;25378556;25418920;25576301;25645385;25662211;25755297;25836925;25892735;26024233;26154972;26811146;26819372;26992070;27397612;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28446606;28510447;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30484775;31154438;31217245;31530632;31844290;31848261;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32561545;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33465208;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34229054;34932366;35051231;35251023;35318648;35561310;35580925;36241641;36284347;37938771;40596516;9618489;9660949",
        "class_list": "",
        "function": "Altered expression of PDIP46 or its mutation may affect Pol delta functions in vivo, and thereby be a nexus for altered genomic stability., [RefSeq, PubMed]; HnRNP-U inhibits TDP-43-mediated alterations in splicing of POLDIP3 mRNA., [RefSeq, PubMed]; Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution., [RefSeq, PubMed]; Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; SKAR is a specific target of S6K1 and regulates cell growth., [RefSeq, PubMed]; SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis., [RefSeq, PubMed]; This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]; This study showed that PDIP46 aka SKAR, a protein possessing one RNA recognition motif (RRM) and being a protein partner of both the p50 subunit of DNA polymerase delta and p70 ribosomal protein S6 kinase 1 (S6K1)., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6F8;A8K6V9;Q009A7;Q5H972;Q6PGN6;Q7Z6Z0;Q9NSP5;Q9NSP6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0045727 positive regulation of translation;GO:0006417 regulation of translation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "Q9BY77-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q147X3-1",
        "uniprot_id": [
            {
                "id": "NAA30_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q147X3",
                "type": "external"
            }
        ],
        "mass": 39320.0,
        "length": 362,
        "protein_name": "N-alpha-acetyltransferase 30",
        "gene_name": "NAA30",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 30",
        "refseq_ac": [
            {
                "id": "NP_001011713",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011713",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA30; C14orf35; MAK3; NAT12",
        "gene_names_refseq": "C14orf35; MAK3; Mak3p; NAA30; NAT12P; NAT12",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 30; 2.3.1.256; N-acetyltransferase 12; N-acetyltransferase MAK3 homolog; NatC catalytic subunit",
        "protein_names_refseq": "N-acetyltransferase 12 (GCN5-related, putative); N-acetyltransferase MAK3 homolog; N-alpha-acetyltransferase 30; natC catalytic subunit; putative N-acetyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122830);  (R-HSA-6811440)",
        "pathway_count": 2,
        "publication_count": 114,
        "publication_id_list": "10209123;10445031;10559959;10637310;10865125;10990452;11237011;11303027;11346801;11359012;11689439;11827983;11839770;12070132;12377769;12620188;12620189;14580338;14718928;15029241;15037235;15077113;15077114;15128430;15269279;15483056;15654769;15758030;15870108;15878329;16042553;16129887;16571679;16885419;16912714;16936697;17451557;17488291;17562788;17684057;17698061;18195106;18243103;18256213;18367545;18664496;18669648;18691976;18946081;19164740;19398576;19490898;19608861;19620288;19660095;19664994;19664995;20068231;20685960;21183348;21421921;21436057;21689688;21807881;22335553;22354037;22581368;22717455;23091056;23186163;23437303;24714562;24794632;25343031;25576301;25645385;25732826;26292663;27846572;28228285;28832583;28855257;29242379;29247799;29557506;29786170;29789417;31844290;31848261;32157095;32387766;32897882;32983136;33298915;33592498;33912179;33968037;34509645;34561969;34932366;35051231;35318648;35580925;37891180;7909812;8221884;8440258;8620540;8636227;8670882;9050864;9177194;9230071;9590177",
        "class_list": "",
        "function": "Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576)., [UniProtKB, PubMed, PubMed]; Human Naa30 (MAK3) is the catalytic subunit of the human NatC N-terminal acetyltransferase complex. NatC acetylates hydrophobic Met-starting N-termini, and NatC knockdown induces p53-dependent apoptosis., [RefSeq, PubMed]; NAT12/NAA30 plays an important role in growth and survival of GICs possibly by regulating hypoxia response (HIF1a), levels of p-MTOR (Ser2448) and the p53 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of full-length Naa30 increased cell viability., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0IIN2",
        "ec_number_list": [
            {
                "id": "2.3.1.256",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.256",
                "type": "external"
            },
            {
                "id": "2.3.1.258",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.258",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031417 NatC complex",
        "go_biological_process": "GO:0050821 protein stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q147X3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y530-1",
        "uniprot_id": [
            {
                "id": "OARD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y530",
                "type": "external"
            }
        ],
        "mass": 17025.0,
        "length": 152,
        "protein_name": "ADP-ribose glycohydrolase OARD1",
        "gene_name": "OARD1",
        "organism": "Human",
        "refseq_name": "ADP-ribose glycohydrolase OARD1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001316613",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316613",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OARD1; C6orf130; TARG1",
        "gene_names_refseq": "C6orf130; OARD1; TARG1; dJ34B21.3",
        "protein_names_uniprotkb": "ADP-ribose glycohydrolase OARD1; 3.2.2.-; 3.5.1.-; O-acetyl-ADP-ribose deacetylase 1; Terminal ADP-ribose protein glycohydrolase 1; [Protein ADP-ribosylglutamate] hydrolase OARD1",
        "protein_names_refseq": "ADP-ribose glycohydrolase OARD1 isoform a; ADP-ribose glycohydrolase OARD1; O-acetyl-ADP-ribose deacetylase 1; O-acetyl-ADP-ribose deacetylase C6orf130; [Protein ADP-ribosylglutamate] hydrolase OARD1; terminal ADP-ribose protein glycohydrolase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221443)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;21406692;21849506;21993680;22223895;23474714;23481255;25576301;25645385;25880248;26091342;26375851;26992070;27397612;28832583;28904123;29557506;29712969;29786170;29789417;30315122;30429286;30779550;30833945;31599159;31844290;31848261;32157095;32350084;32357974;32387766;32427867;32488085;32502341;32897882;32938616;32983136;33592498;33691108;33717175;33968037;33981976;34087483;34171305;34508355;34932366;35051231;35318648;35580925;36010968;37217939",
        "class_list": "",
        "function": "ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:21849506, PubMed:23474714, PubMed:23481255). Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins (PubMed:23474714, PubMed:23481255). Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 (PubMed:23481255). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21849506). Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively (PubMed:21849506)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; C6orf130 enzymatic activity has a role in the turnover and recycling of protein ADP-ribosylation in neurodegenerative disease., [RefSeq, PubMed]; Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties., [RefSeq, PubMed]; Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation. Review article, [RefSeq, PubMed]; TARG1 protects against toxic DNA ADP-ribosylation., [RefSeq, PubMed]; The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NEK4;A8K4H4;Q96F23",
        "ec_number_list": [
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-",
                "type": "external"
            },
            {
                "id": "3.2.2.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19",
                "type": "external"
            },
            {
                "id": "3.1.1.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.106",
                "type": "external"
            },
            {
                "id": "3.2.1.143",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0001883 purine nucleoside binding;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0090734 site of DNA damage;GO:0005694 chromosome",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9Y530-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NGQ2-1",
        "uniprot_id": [
            {
                "id": "OOEP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NGQ2",
                "type": "external"
            }
        ],
        "mass": 17170.0,
        "length": 149,
        "protein_name": "Oocyte-expressed protein homolog",
        "gene_name": "OOEP",
        "organism": "Human",
        "refseq_name": "oocyte-expressed protein homolog isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001073976",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073976",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OOEP; C6orf156; KHDC2; OEP19",
        "gene_names_refseq": "C6orf156; FLOPED; HOEP19; KHDC2; OOEP",
        "protein_names_uniprotkb": "Oocyte-expressed protein homolog; KH homology domain-containing protein 2; Oocyte- and embryo-specific protein 19; hOEP19",
        "protein_names_refseq": "KH homology domain containing 2; KH homology domain-containing protein 2; oocyte and embryo protein 19; oocyte expressed protein homolog (dog); oocyte- and embryo-specific protein 19; oocyte-expressed protein homolog isoform 1; oocyte-expressed protein homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441161)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;17913455;23481700;25542835;26537248;35946397;37148315;39379527",
        "class_list": "",
        "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes. Thereby contributes to oocyte survival and the resumption and completion of meiosis., [UniProtKB, UniProtKB]; Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIN5;A9UIB7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0140094 structural constituent of cytoplasmic lattice",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0032991 protein-containing complex;GO:0106333 subcortical maternal complex",
        "go_biological_process": "GO:0045836 positive regulation of meiotic nuclear division;GO:0051293 establishment of spindle localization;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization;GO:0040019 positive regulation of embryonic development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A6NGQ2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NY56-1",
        "uniprot_id": [
            {
                "id": "OBP2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NY56",
                "type": "external"
            }
        ],
        "mass": 19318.0,
        "length": 170,
        "protein_name": "Odorant-binding protein 2a",
        "gene_name": "OBP2A",
        "organism": "Human",
        "refseq_name": "odorant-binding protein 2a isoform gamma precursor",
        "refseq_ac": [
            {
                "id": "NP_001280118",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280118",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OBP2A",
        "gene_names_refseq": "LCN13; OBP2A; OBP2C; OBPIIa; OBP; hOBPIIa",
        "protein_names_uniprotkb": "Odorant-binding protein 2a; OBPIIa; Odorant-binding protein IIa",
        "protein_names_refseq": "odorant-binding protein 2a isoform gamma precursor; odorant-binding protein IIa; putative odorant-binding protein 2c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29991)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10607840;11237011;12044155;16546182;25810031;27827363;33467165;33671721;35051231;35341882;35494241;36547668;38493698",
        "class_list": "",
        "function": "A polymorphism in the human gene encoding OBPIIa affects the perceived intensity of smelled odors., [RefSeq, PubMed]; Binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids, including undecanal, palmitic acid, efficient aldehydes, benzenic aldehydes, heterocyclic aldehydes and aliphatic acids., [UniProtKB, PubMed, PubMed]; Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes. Publication Status: Online-Only, [RefSeq, PubMed]; Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation., [RefSeq, PubMed]; HOBPIIa(alpha) is expressed in the nasal mucus covering the olfactory cleft and is able to bind numerous odorants of diverse chemical structures, with a higher affinity for aldehydes and large fatty acids., [RefSeq, PubMed]; Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Tumor-derived OBP2A promotes prostate cancer castration resistance., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T8A3;Q9NY50;Q9NY53;Q9NY54;Q9NY55",
        "ec_number_list": [],
        "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0042593 glucose homeostasis;GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9NY56-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UPR5-1",
        "uniprot_id": [
            {
                "id": "NAC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UPR5",
                "type": "external"
            }
        ],
        "mass": 100368.0,
        "length": 921,
        "protein_name": "Sodium/calcium exchanger 2",
        "gene_name": "SLC8A2",
        "organism": "Human",
        "refseq_name": "sodium/calcium exchanger 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_055878",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055878",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC8A2; KIAA1087; NCX2",
        "gene_names_refseq": "NCX2; SLC8A2",
        "protein_names_uniprotkb": "Sodium/calcium exchanger 2; Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2",
        "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+-exchanging protein Nac2; sodium/calcium exchanger 2 precursor; sodium/calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; solute carrier family 8 member 2",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)",
        "pathway": " (hsa:6543);  (R-HSA-418359);  (R-HSA-425561);  (R-HSA-5578775)",
        "pathway_count": 4,
        "publication_count": 73,
        "publication_id_list": "10220561;10662833;10913253;11062458;11237011;11294880;11904675;12119109;12379639;12406570;12832055;12953268;1374913;14625281;14978097;15060069;15174025;15260953;15598648;15754088;16357253;16679322;16754674;1693919;17224452;17357072;17486119;18166528;18995841;19278978;19751721;19913121;20132488;20298697;20388710;21108950;22210847;2226863;22427649;22707725;22972900;23362265;23506867;23549614;23610579;2430951;24501278;24715725;2477373;2559024;25994790;26421717;2838329;2844759;28645727;2953725;31092671;31154438;31247120;32075715;32488085;33392160;34127021;36334237;5961668;6328127;7702581;7929371;8021246;8798450;8918259;9346285;9856482",
        "class_list": "",
        "function": "Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion., [UniProtKB, UniProtKB]; Methylation on SLC8A2 is associated with the development of anti-tuberculosis drug-induced liver injury., [RefSeq, PubMed]; MiR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA., [RefSeq, PubMed]; NCX2 Regulates Intracellular Calcium Homeostasis and Translocation of HIF-1alpha into the Nucleus to Inhibit Glioma Invasion., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins, [RefSeq, PubMed]; The aim of this study was to investigate if NCX2 might be a tumour suppressor gene involved in glioma. Results indicate that DNA methylation may play a key role in the transcriptional silencing of NCX2., [RefSeq, PubMed]; The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DYQ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015085 calcium ion transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0030425 dendrite",
        "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0002931 response to ischemia;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q9UPR5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86U42-1",
        "uniprot_id": [
            {
                "id": "PABP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86U42",
                "type": "external"
            }
        ],
        "mass": 32749.0,
        "length": 306,
        "protein_name": "Polyadenylate-binding protein 2",
        "gene_name": "PABPN1",
        "organism": "Human",
        "refseq_name": "polyadenylate-binding protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004634",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004634",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PABPN1; PAB2; PABP2",
        "gene_names_refseq": "OPMD; PAB2; PABII; PABP-2; PABP2; PABPN1",
        "protein_names_uniprotkb": "Polyadenylate-binding protein 2; Nuclear poly(A)-binding protein 1; PABII; PABP-2; Poly(A)-binding protein 2; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1",
        "protein_names_refseq": "poly(A) binding protein 2; poly(A) binding protein II; polyadenylate-binding protein 2 isoform 1; polyadenylate-binding protein 2",
        "tax_id": 9606,
        "disease": "oculopharyngeal muscular dystrophy (Disease Ontology:DOID:11719)",
        "pathway": " (hsa:8106);  (R-HSA-168315);  (R-HSA-72187);  (R-HSA-73856);  (R-HSA-77595);  (R-HSA-9770562);  (R-HSA-9820865);  (R-HSA-9918481);  (R-HSA-9930044)",
        "pathway_count": 9,
        "publication_count": 135,
        "publication_id_list": "10205180;10669729;10688363;11001936;11060040;11237011;11371506;11421366;11689481;11747608;11979277;12667806;12673802;12871933;14519844;14663186;14749727;14762106;15037765;15084397;15169763;15565158;15998806;17081983;17103222;17128255;17174896;17190602;17289661;17412707;17984224;18288197;18411249;18669648;18957205;19217410;19413330;19415658;19651622;19664995;19690332;19836239;20058876;20068231;20573985;20695905;20844015;21295486;21406692;21700224;21705430;21855801;21911577;21947206;22207203;22223895;22813749;22928037;23186163;23222130;23299939;23481700;23874216;24029068;24076191;24129315;24149845;24244187;24275569;25301780;25301781;25576301;25578728;25662211;25836925;25963658;26092250;26154972;26375851;27108190;27209344;27434818;27846572;27871484;28096519;28510447;28904123;28911096;29186539;29253183;29274231;29298432;29493099;29557506;29902443;29906447;30139799;30192525;30257008;30379171;30599162;31844290;31950173;32157095;32502341;32816001;32938616;32983136;33177556;33214551;33298915;33465208;33767452;33912179;33913806;33968037;34019948;34561969;35177536;35215846;35580925;36215666;37356722;37422193;37875486;38244911;38253038;38665916;38943343;40596516;40914422;9462747;9651582;9659921;9986787",
        "class_list": "",
        "function": "Data indicate that intron 6 of the poly(A)-binding protein nuclear 1 (PABPN1) gene is required for autoregulation., [RefSeq, PubMed]; Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1., [RefSeq, PubMed]; Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484)., [UniProtKB, PubMed, PubMed, UniProtKB]; PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation., [RefSeq, PubMed]; Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics., [RefSeq, PubMed]; This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DS49;O43484",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0070063 RNA polymerase binding;GO:0008143 poly(A) binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0006936 muscle contraction;GO:0000165 MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "Q86U42-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYS5-1",
        "uniprot_id": [
            {
                "id": "OSCAR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYS5",
                "type": "external"
            }
        ],
        "mass": 30481.0,
        "length": 282,
        "protein_name": "Osteoclast-associated immunoglobulin-like receptor",
        "gene_name": "OSCAR",
        "organism": "Human",
        "refseq_name": "osteoclast-associated immunoglobulin-like receptor isoform 4 precursor",
        "refseq_ac": [
            {
                "id": "NP_573399",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573399",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OSCAR",
        "gene_names_refseq": "OSCAR; PIGR3; PIgR-3",
        "protein_names_uniprotkb": "Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; PIgR-3; PIgR3; Poly-Ig receptor 3; Polymeric immunoglobulin receptor 3; hOSCAR",
        "protein_names_refseq": "osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; osteoclast associated, immunoglobulin-like receptor; osteoclast-associated immunoglobulin-like receptor isoform 4 precursor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126014);  (R-HSA-198933);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 99,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11805147;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15650060;15778510;15781451;15800062;15851719;15864273;15905516;16007331;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23650620;23695528;23929856;24305946;25703557;25716998;26284469;26300885;26552697;26786702;26992070;28555364;29557506;30459171;30833945;32157095;32246488;32859940;32983136;33043033;34171305;35051231;35580925;7531291;7542404;8178173;8692836;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1., [RefSeq, PubMed]; HOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response., [RefSeq, PubMed]; Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor., [RefSeq, PubMed]; Ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules, [RefSeq, PubMed]; OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis., [RefSeq, PubMed]; Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]., [RefSeq]; Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women., [RefSeq, PubMed]; Regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts, [RefSeq, PubMed]; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation., [UniProtKB]; Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7WNS2;Q5GRG5;Q8N763;Q8NHL4;Q8WXQ0;Q8WXQ1;Q8WXQ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038064 collagen receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0035580 specific granule lumen;GO:1904724 tertiary granule lumen",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q8IYS5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P41271-1",
        "uniprot_id": [
            {
                "id": "NBL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P41271",
                "type": "external"
            }
        ],
        "mass": 19408.0,
        "length": 181,
        "protein_name": "Neuroblastoma suppressor of tumorigenicity 1",
        "gene_name": "NBL1",
        "organism": "Human",
        "refseq_name": "neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001191013",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191013",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NBL1; DAND1; DAN",
        "gene_names_refseq": "D1S1733E; DAND1; DAN; NBL1; NB; NO3",
        "protein_names_uniprotkb": "Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN",
        "protein_names_refseq": "DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma 1, DAN family BMP antagonist; neuroblastoma candidate region, suppression of tumorigenicity 1; neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor; neuroblastoma suppressor of tumorigenicity 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100532736);  (hsa:4681)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11594460;25502872;26791533;29557506;29671580;30237853;30459171;31154438;32125861;33592498;34078123;35051231;35289036;35947673;37217939;37436574;8084583",
        "class_list": "",
        "function": "Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes., [RefSeq, PubMed]; Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy., [RefSeq, PubMed]; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A3KFI7;Q5TGZ2;Q5U0N4;Q96L68",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0048018 receptor ligand activity;GO:0016015 morphogen activity;GO:0036122 BMP binding;GO:0140311 protein sequestering activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0090027 negative regulation of monocyte chemotaxis;GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0048812 neuron projection morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "P41271-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96Q15-1",
        "uniprot_id": [
            {
                "id": "SMG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96Q15",
                "type": "external"
            }
        ],
        "mass": 410501.0,
        "length": 3661,
        "protein_name": "Serine/threonine-protein kinase SMG1",
        "gene_name": "SMG1",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase SMG1",
        "refseq_ac": [
            {
                "id": "NP_055907",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055907",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SMG1; ATX; KIAA0421; LIP",
        "gene_names_refseq": "61E3.4; ATX; LIP; SMG1",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase SMG1; 2.7.11.1; Lambda-interacting protein; Lambda/iota protein kinase C-interacting protein; Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1; SMG-1; hSMG-1",
        "protein_names_refseq": "PI-3-kinase-related kinase SMG-1; SMG1 phosphatidylinositol 3-kinase-related kinase; lambda-interacting protein; lambda/iota protein kinase C-interacting protein; nonsense mediated mRNA decay-associated PI3K-related kinase SMG1; serine/threonine-protein kinase SMG1; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23049);  (R-HSA-975957)",
        "pathway_count": 2,
        "publication_count": 161,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11331269;11532962;11544179;11546874;11551508;11948212;12417715;12554878;12718880;12832468;14527413;14636577;14742663;14973490;15034551;15175154;15546618;15721257;16186820;16209946;16284618;16452507;16601204;16964243;17053788;17081983;17344846;17352659;17363904;17525332;17803942;17893241;18066079;18077418;18256688;18423202;18452278;18524595;18657639;18669648;18691976;18974281;19060897;19150429;19359157;19413330;19417104;19478851;19503078;19556969;19608861;19651622;19664994;19859661;19909264;20023408;20068231;20371770;20427287;20479275;20691628;20810650;20817927;20930030;21145460;21245168;21419344;22424782;23085078;23186163;23234702;23481700;24275569;24397554;24715725;25220460;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26841701;26929215;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30410026;30484775;30524438;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34761935;34842356;34932366;35051231;35494241;35561310;35580925;36010968;36215666;36241641;36284347;36400430;36581221;37938771;8524286;9566925",
        "class_list": "",
        "function": "Large-scale genomic sequencing reveals adaptive opportunity of targeting mutated-PI3Kalpha in early and advanced HER2-positive breast cancer., [RefSeq, PubMed]; SMG1 and CDK12 Link DeltaNp63alpha Phosphorylation to RNA Surveillance in Keratinocytes., [RefSeq, PubMed]; SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma., [RefSeq, PubMed]; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 62,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43305;Q13284;Q8NFX2;Q96QV0;Q96RW3",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033391 chromatoid body",
        "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0006406 mRNA export from nucleus;GO:0006974 DNA damage response;GO:0046777 protein autophosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "Q96Q15-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.001000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q05086-1",
        "uniprot_id": [
            {
                "id": "UBE3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q05086",
                "type": "external"
            }
        ],
        "mass": 100688.0,
        "length": 875,
        "protein_name": "Ubiquitin-protein ligase E3A",
        "gene_name": "UBE3A",
        "organism": "Human",
        "refseq_name": "ubiquitin-protein ligase E3A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_000453",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000453",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBE3A; E6AP; EPVE6AP; HPVE6A",
        "gene_names_refseq": "ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1; UBE3A",
        "protein_names_uniprotkb": "Ubiquitin-protein ligase E3A; 2.3.2.26; E6AP ubiquitin-protein ligase; HECT-type ubiquitin transferase E3A; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54",
        "protein_names_refseq": "CTCL tumor antigen se37-2; E6AP ubiquitin-protein ligase; HECT-type ubiquitin transferase E3A; human papilloma virus E6-associated protein; human papillomavirus E6-associated protein; oncogenic protein-associated protein E6-AP; renal carcinoma antigen NY-REN-54; ubiquitin-protein ligase E3A isoform 2",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 15q11.2 deletion syndrome (Disease Ontology:DOID:0060393); intellectual disability (Disease Ontology:DOID:1059); epilepsy (Disease Ontology:DOID:1826); Angelman syndrome (Disease Ontology:DOID:1932)",
        "pathway": " (hsa:7337);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 128,
        "publication_id_list": "10373495;10508479;10558980;10983987;11062501;11170455;11237011;11350924;12207887;12646216;14734113;15224091;15224092;15571818;16595681;16772533;16849449;16954532;17108031;17323924;17525332;18077418;18662542;18991276;19028597;19204938;19233847;19325566;19352404;19452197;19489725;19591933;19690332;19851334;19874575;19940261;20068231;21642474;21947926;2261476;22645313;23301498;23581475;24273172;24728990;25212744;25418920;25576301;25645385;25880248;26154972;26375851;26811146;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28649982;28832583;28834231;28855257;28904123;29242379;29351928;29393594;29437277;29493099;29557506;29632046;29786170;30020076;30315122;30379171;30410026;30484775;30524438;30620550;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33717175;33912179;33968037;33981976;34087483;34185709;34357683;34561969;34932366;35051231;35318648;35580925;36010968;36284347;37938771;38395183;38423246;38520260;38665916;39126903;40914422;8380895;8988171;8988172;9143503;9288087;9380723;9585605;9668046;9688277",
        "class_list": "",
        "function": "(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses., [UniProtKB, PubMed]; CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP., [RefSeq, PubMed]; Neuronal UBE3A substrates hold therapeutic potential for Angelman syndrome. Review article, [RefSeq, PubMed]; This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; UBE3A gene exhibits tissue-specific imprinting, with monoallelic expression from the maternal allele only in brain, but biallelic expression in other tissues., [RefSeq, PubMed]; Undiagnosed rare disease clinic identifies a novel UBE3A variant in two sisters with Angelman syndrome: The end of a diagnostic odyssey., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8Z9;P78355;Q93066;Q9UEP4;Q9UEP5;Q9UEP6;Q9UEP7;Q9UEP8;Q9UEP9",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex",
        "go_biological_process": "GO:0006508 proteolysis;GO:0048167 regulation of synaptic plasticity;GO:0007420 brain development;GO:0032570 response to progesterone;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q05086-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43422-1",
        "uniprot_id": [
            {
                "id": "P52K_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43422",
                "type": "external"
            }
        ],
        "mass": 87704.0,
        "length": 761,
        "protein_name": "52 kDa repressor of the inhibitor of the protein kinase",
        "gene_name": "THAP12",
        "organism": "Human",
        "refseq_name": "52 kDa repressor of the inhibitor of the protein kinase",
        "refseq_ac": [
            {
                "id": "NP_004696",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004696",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "THAP12; DAP4; P52RIPK; PRKRIR; THAP0",
        "gene_names_refseq": "DAP4; P52rIPK; PRKRIR; THAP0; THAP12",
        "protein_names_uniprotkb": "52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; Death-associated protein 4; THAP domain-containing protein 0; THAP domain-containing protein 12; p52rIPK; p58IPK-interacting protein",
        "protein_names_refseq": "52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; P58IPK-regulatory protein; THAP domain-containing protein 0; THAP domain-containing protein 12; death-associated protein 4; inhibitor of protein kinase PKR; p58IPK-interacting protein; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); testicular tissue protein Li 133",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5612)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;20628624;20934997;21910972;23186163;25576301;25880248;26992070;27600516;27862975;28228285;28514659;28834231;28904123;29557506;30410026;31154438;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32938616;33298915;33912179;33968037;33981976;35051231;35580925;36010968;9447982",
        "class_list": "",
        "function": "Meta-analysis of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; PRKRIR provides a novel positive regulator controlling the RIG-I-IFN production system through protein stability control., [RefSeq, PubMed]; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K728;Q17RY9;Q8WTW1;Q9Y3Z4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046983 protein dimerization activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "O43422-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WV07-1",
        "uniprot_id": [
            {
                "id": "LTO1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WV07",
                "type": "external"
            }
        ],
        "mass": 15354.0,
        "length": 137,
        "protein_name": "Protein LTO1 homolog",
        "gene_name": "LTO1",
        "organism": "Human",
        "refseq_name": "protein LTO1 homolog",
        "refseq_ac": [
            {
                "id": "NP_703152",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703152",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LTO1; ORAOV1; TAOS1",
        "gene_names_refseq": "CIAB1; LTO1; ORAOV1; TAOS1",
        "protein_names_uniprotkb": "Protein LTO1 homolog; Oral cancer-overexpressed protein 1; Tumor-amplified and overexpressed sequence 1",
        "protein_names_refseq": "LTO1, ABCE1 maturation factor; oral cancer overexpressed 1; oral cancer overexpressed protein 1-A; oral cancer-overexpressed protein 1; protein LTO1 homolog; tumor-amplified and overexpressed sequence 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:220064)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;12172009;17005439;18688849;19493886;20105337;21406692;23318452;24930674;26182403;28514659;28832583;29242379;31844290;32938616;33161447;33592498;33655785;35580925;37930255",
        "class_list": "",
        "function": "Data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC, [RefSeq, PubMed]; High-resolution mapping of the 11q13 amplicon and identification of a gene that is amplified and overexpressed in oral cancer cells, [RefSeq, PubMed]; In OSCC tissue samples, the expression frequency of ORAOV1-A (51.1%) was much higher than that in normal samples (10.5%).  ORAOV1-A may play a functional role in the tumorigenesis of OSCC., [RefSeq, PubMed]; ORAOV1 has an important role in regulating cell growth of cervical cancer HeLa cells through regulating the cell cycle and apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; ORAOV1 plays pivotal roles in the growth and angiogenesis of oral squamous cell carcinoma., [RefSeq, PubMed]; ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma., [RefSeq, PubMed]; ORAOV1-B Promotes OSCC Metastasis via the NF-kappaB-TNFalpha Loop., [RefSeq, PubMed]; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674)., [UniProtKB, PubMed, PubMed, PubMed]; Validation of ORAOV1 as a new treatment target in hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4R2;Q8NFK0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000723 telomere maintenance;GO:0006413 translational initiation;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q8WV07-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P60201-1",
        "uniprot_id": [
            {
                "id": "MYPR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P60201",
                "type": "external"
            }
        ],
        "mass": 30077.0,
        "length": 277,
        "protein_name": "Myelin proteolipid protein",
        "gene_name": "PLP1",
        "organism": "Human",
        "refseq_name": "myelin proteolipid protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000524",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000524",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLP1; PLP",
        "gene_names_refseq": "GPM6C; HLD1; MMPL; PLP/DM20; PLP1; PLP; PMD; SPG2",
        "protein_names_uniprotkb": "Myelin proteolipid protein; Lipophilin; PLP",
        "protein_names_refseq": "lipophilin; major myelin proteolipid protein; myelin proteolipid protein isoform 1; myelin proteolipid protein",
        "tax_id": 9606,
        "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hereditary spastic paraplegia 2 (Disease Ontology:DOID:0110773); intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); Pelizaeus-Merzbacher disease (Disease Ontology:DOID:3210)",
        "pathway": " (hsa:5354)",
        "pathway_count": 1,
        "publication_count": 75,
        "publication_id_list": "10319897;10417279;10425042;11093273;11237011;11786921;11801634;1374422;1376966;1384324;15450775;15712223;15748942;16750575;1707231;1708672;1711121;1715570;17438221;18506883;20036320;22140475;22316121;24103481;2441695;2449536;2479017;2480601;25645385;27231714;2773936;28657654;29170668;29557506;31154438;31848261;32157095;32488085;3467339;35217805;37217939;37475517;37938771;4041237;7511703;7522741;7526383;7531827;7539213;7541731;7542375;7573159;7679906;7683951;7684886;8012387;8037216;8598487;8780101;8833089;8909455;8956049;9008538;9058754;9143933;9278634;9366420;9482656;9489796;9574529;9633722;9747038;9788732;9894878;9934976",
        "class_list": "",
        "function": "Microdeletion in distal PLP1 enhancers causes hereditary spastic paraplegia 2., [RefSeq, PubMed]; These results suggest for the first time that PLP may have functions in humans not only in oligodendrocytes but also in neurons and could be implicated in axono-glial communication, [RefSeq, PubMed]; This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]., [RefSeq]; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P04400;P06905;Q502Y1;Q6FHZ6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0042802 identical protein binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045202 synapse",
        "go_biological_process": "GO:0022010 central nervous system myelination;GO:0007268 chemical synaptic transmission;GO:0021762 substantia nigra development;GO:0061564 axon development;GO:0008366 axon ensheathment",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "P60201-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53GL7-1",
        "uniprot_id": [
            {
                "id": "PAR10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53GL7",
                "type": "external"
            }
        ],
        "mass": 109998.0,
        "length": 1025,
        "protein_name": "Protein mono-ADP-ribosyltransferase PARP10",
        "gene_name": "PARP10",
        "organism": "Human",
        "refseq_name": "protein mono-ADP-ribosyltransferase PARP10 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_116178",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116178",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PARP10",
        "gene_names_refseq": "ARTD10; PARP10",
        "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP10; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10; PARP-10; Poly [ADP-ribose] polymerase 10",
        "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 10; poly [ADP-ribose] polymerase 10; protein mono-ADP-ribosyltransferase PARP10 isoform 1; protein mono-ADP-ribosyltransferase PARP10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84875);  (R-HSA-196807);  (R-HSA-9683610);  (R-HSA-9694631)",
        "pathway_count": 4,
        "publication_count": 137,
        "publication_id_list": "10331643;10613898;11237011;11248244;11594753;11788603;11866528;11991719;12359228;12547821;12574164;12790796;13563527;14516279;14966140;15090606;15137942;15381699;15674325;15848177;16103198;16118205;1637327;16455663;16690024;17402747;17604275;17641676;17868694;17914902;18411268;18851833;19106108;19531469;19608861;20068231;20106667;20388704;2129526;21504897;21699903;21933152;21994945;22176891;22544926;22701565;22822066;23186163;23212377;23230272;23332125;23473667;23474714;23475216;23481700;24275569;24366607;24695737;24714562;24715725;24717514;24847004;25043379;25505266;25531177;25576301;25589627;26154972;26375851;26598975;26992070;27846572;27862975;28904123;29199039;29351928;29557506;30032250;30315122;30429286;30484775;30833945;31092671;31154438;31217245;31530632;31844290;31848261;31937595;31998317;32029454;32060423;32157095;32357974;32387766;32392194;32488085;32502341;32637943;32645325;32723359;32817937;32877642;32897882;32906142;32938616;32983136;33059680;33087354;33141586;33248025;33298915;33592498;33717175;33912179;33968037;33997890;34029587;34171305;34405274;34509645;34593624;34932366;35051231;35318648;35580925;36010968;36215666;37506247;37938771;4349867;8182091;8289818;8527488;8575745;8809081;9473669",
        "class_list": "",
        "function": "ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Alternative catalytic mechanism for PARP10 compared to PARP1 in which the acidic target residue of the substrate functionally substitutes for the catalytic glutamate by using substrate-assisted catalysis to transfer ADP-ribose, [RefSeq, PubMed]; Novel PARP enzyme involved in the control of cell proliferation, [RefSeq, PubMed]; Overexpression of PARP10 results in loss of cell viability, although down-expression by short hairpin RNA leads to delayed G1 progression and concomitant cell death., [RefSeq, PubMed]; PARP10 is highly expressed and associated with inferior outcomes in acute myeloid leukemia., [RefSeq, PubMed]; PARP10 promotes cellular proliferation, and its overexpression alleviates cellular sensitivity to replication stress and fosters the restart of stalled replication forks. In mouse xenograft studies, PARP10 loss reduces the tumorigenesis activity of HeLa cells. Its overexpression results in tumor formation by non-transformed RPE-1 cells.  PARP10 may promote cellular transformation by alleviating replication stress., [RefSeq, PubMed]; PLK1/NF-kappaB feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression., [RefSeq, PubMed]; Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]., [RefSeq]; Study results show that the interaction between PARP10 and NS1 of H5N1 avian influenza virus can change cell cycle, and PARP10 can affect virus replication Publication Status: Online-Only, [RefSeq, PubMed]; The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K(+) channel Kv1.1 through protein kinase C delta. Publication Status: Online-Only, [RefSeq, PubMed]; [PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N2I0;Q8WV05;Q96CH7;Q96K72",
        "ec_number_list": [
            {
                "id": "2.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-",
                "type": "external"
            },
            {
                "id": "2.4.2.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.286",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003714 transcription corepressor activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0070213 protein auto-ADP-ribosylation;GO:0006281 DNA repair;GO:0010629 negative regulation of gene expression;GO:0043124 negative regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 14.1,
        "record_id": "Q53GL7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13459-1",
        "uniprot_id": [
            {
                "id": "MYO9B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13459",
                "type": "external"
            }
        ],
        "mass": 243401.0,
        "length": 2157,
        "protein_name": "Unconventional myosin-IXb",
        "gene_name": "MYO9B",
        "organism": "Human",
        "refseq_name": "unconventional myosin-IXb isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004136",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004136",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO9B; MYR5",
        "gene_names_refseq": "CELIAC4; MYO9B; MYR5",
        "protein_names_uniprotkb": "Unconventional myosin-IXb; Unconventional myosin-9b",
        "protein_names_refseq": "myosin-IXb; unconventional myosin-9b; unconventional myosin-IXb isoform 1; unconventional myosin-IXb",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4650);  (R-HSA-2029482);  (R-HSA-8980692);  (R-HSA-8985586);  (R-HSA-9013026);  (R-HSA-9013106);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9035034);  (R-HSA-9664422)",
        "pathway_count": 10,
        "publication_count": 473,
        "publication_id_list": "10037681;10219243;10232922;10464238;10490598;10496324;10508610;10523665;10523675;10526156;10559246;10559936;10579713;10580159;10619026;10699171;10699464;10724160;10781580;10873388;10873802;10878810;10958683;10995437;11007481;11058585;11085924;11149925;11157975;11207612;11231582;11237011;11276226;11278486;11306516;11329366;11340081;11373293;11396949;11431473;11432776;11553796;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11747816;11756552;11773441;11801597;11803464;11804587;11804589;11804590;11829459;11854399;11884391;11912491;11948177;11961559;12055636;12071859;12093360;12096337;12105426;12172552;12189515;12195014;12213210;12221077;12221096;12235133;12351724;12432077;12464619;12473120;12531887;12546821;12547822;12650940;12665586;12743368;12773384;12857875;12860998;12877655;12907671;12923183;1314888;14506234;14512443;14514689;1464587;14675773;14676198;14718541;15023524;15033976;15040784;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15452139;15485661;15507211;15579468;15601624;15611138;15657136;15728722;15850391;15858067;15866170;15897194;15944396;16002401;16112081;16116428;16184169;16217026;16243036;16262445;16467373;16473593;16492808;16507994;16519628;16546099;16630611;16636067;16641196;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16880808;16896804;16914516;16917499;16964243;16968698;17064668;17077126;17081983;17145773;17188549;17196961;17198702;17202194;17214551;17244649;17308335;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18070890;18088087;18158243;18218625;18249095;18347018;18363964;18391171;18396277;18426980;18452278;18653540;18669648;18691976;18707149;18786931;18802007;18829452;18835169;18838382;18929667;19007248;19269969;19367720;19369195;19413330;19494238;19605563;19635168;19651622;19664994;19664995;19673492;19690332;19713215;19741094;19934221;19955216;20030946;20068231;20101212;20166139;20233848;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21037092;21119010;21148482;21351730;21373644;21406692;21419341;21454492;21542010;21565175;21576392;21613211;21685891;21699497;21730051;21757538;21865595;21936715;21989057;22004470;22028470;22096251;22298643;22305756;22407364;22424782;22461490;22475431;22571869;22608513;22673745;22734669;22790947;22911862;22970203;22992742;23096567;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23572525;23675550;23707487;23718289;23783831;23870313;23940355;24086303;24128008;24259668;24275569;24335996;24352656;24366607;24584464;24715725;2474607;24859002;24933155;24960694;24996924;25024229;25211221;25425145;25428919;25505266;25576301;25668492;25673874;25704760;25721503;25795300;25862245;25963737;26129894;26154972;26299518;26371245;26529257;26598554;26887924;26992070;27096001;27117132;27145964;27216196;27278019;27481945;27555588;27566826;27600516;27713499;27798618;27806292;27846572;27862975;27869121;27920218;27986909;28028151;28112683;28114311;28196833;28218747;28228285;28514659;28584191;28825699;28832583;28834231;28860633;28904123;29089502;29146911;29242379;29358323;29382922;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30061681;30315122;30379171;30410026;30429286;30484775;30524438;30779550;30784271;30853411;31092671;31105010;31154438;31217245;31530632;31844290;31871319;32157095;32203420;32265295;32350084;32357974;32387766;32488085;32502341;32692911;32897882;32938616;32983136;33046503;33123756;33268376;33298915;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34357683;34932366;35051231;35154160;35561310;35580925;36010968;36241641;36260368;36284347;37749140;37938771;38665916;7479768;7512369;7559638;7673236;7721814;7753201;7835339;7848918;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8809042;8810315;8816443;8907710;8939998;8986718;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9600938;9659915;9670022;9705280;9792683;9799231;9822598;9822605;9829970;9843499;9846874;9883880;9885284;9988689",
        "class_list": "",
        "function": "Local Myo9b RhoGAP activity regulates cell motility., [RefSeq, PubMed]; Mutations in MYO9B are associated with Charcot-Marie-Tooth disease type 2 neuropathies and isolated optic atrophy., [RefSeq, PubMed]; Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset. Publication Status: Online-Only, [RefSeq, PubMed]; Myosin-IXb is a single-headed and processive motor, [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257)., [UniProtKB, PubMed, PubMed]; TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response., [RefSeq, PubMed]; The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets., [RefSeq, PubMed]; This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 36,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75314;Q9NUJ2;Q9UHN0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005938 cell cortex",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007266 Rho protein signal transduction;GO:0030048 actin filament-based movement;GO:0035023 regulation of Rho protein signal transduction;GO:0072673 lamellipodium morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 47.6,
        "record_id": "Q13459-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NPH6-1",
        "uniprot_id": [
            {
                "id": "OBP2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NPH6",
                "type": "external"
            }
        ],
        "mass": 19457.0,
        "length": 170,
        "protein_name": "Odorant-binding protein 2b",
        "gene_name": "OBP2B",
        "organism": "Human",
        "refseq_name": "odorant-binding protein 2b precursor",
        "refseq_ac": [
            {
                "id": "NP_001275916",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275916",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OBP2B; PRO1283",
        "gene_names_refseq": "LCN14; OBP2B; OBPIIb",
        "protein_names_uniprotkb": "Odorant-binding protein 2b; OBPIIb; Odorant-binding protein IIb",
        "protein_names_refseq": "odorant-binding protein 2b precursor; odorant-binding protein 2b; odorant-binding protein IIb",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29989)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "10607840;12975309;29557506;33795748",
        "class_list": "",
        "function": "A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B. Publication Status: Online-Only, [RefSeq, PubMed]; Probably binds and transports small hydrophobic volatile molecules., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VSP6;Q9NY51;Q9NY52",
        "ec_number_list": [],
        "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007635 chemosensory behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q9NPH6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BPZ3-1",
        "uniprot_id": [
            {
                "id": "PAIP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BPZ3",
                "type": "external"
            }
        ],
        "mass": 14984.0,
        "length": 127,
        "protein_name": "Polyadenylate-binding protein-interacting protein 2",
        "gene_name": "PAIP2",
        "organism": "Human",
        "refseq_name": "polyadenylate-binding protein-interacting protein 2",
        "refseq_ac": [
            {
                "id": "NP_001028284",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028284",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAIP2; HSPC218; PAIP2A",
        "gene_names_refseq": "PAIP-2; PAIP2A; PAIP2",
        "protein_names_uniprotkb": "Polyadenylate-binding protein-interacting protein 2; PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2",
        "protein_names_refseq": "PABC1-interacting protein 2; PABP-interacting protein 2; polyA-binding protein-interacting protein 2; polyadenylate-binding protein-interacting protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51247)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11172725;11230166;11237011;11287632;11438674;12820898;16804161;24714562;27846572;30429286;31844290;32897882;32938616;33717175;33912179;33936100;33968037;34932366;35051231",
        "class_list": "",
        "function": "Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Role of PAIP2 in modulation of GLUT5 mRNA stability., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBI1;D3DQC6;Q49A06;Q9H0Y5;Q9P0Q8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003729 mRNA binding;GO:0030371 translation repressor activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9BPZ3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P78345-1",
        "uniprot_id": [
            {
                "id": "RPP38_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P78345",
                "type": "external"
            }
        ],
        "mass": 31834.0,
        "length": 283,
        "protein_name": "Ribonuclease P protein subunit p38",
        "gene_name": "RPP38",
        "organism": "Human",
        "refseq_name": "ribonuclease P protein subunit p38",
        "refseq_ac": [
            {
                "id": "NP_001091059",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091059",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPP38",
        "gene_names_refseq": "RPP38",
        "protein_names_uniprotkb": "Ribonuclease P protein subunit p38; RNaseP protein p38",
        "protein_names_refseq": "RNaseP protein p38; ribonuclease P protein subunit p38; ribonuclease P/MRP 38kDa subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10557);  (R-HSA-6784531);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 123,
        "publication_id_list": "10444065;11237011;11455963;11727826;11871657;11922599;12068309;12138183;12150911;12526808;12711671;12729736;15109492;15317868;16037817;16043514;16361254;16710424;16723659;16738141;17189298;17204286;17224653;17353269;17412707;18065403;18226598;18438418;18452278;18669648;18809514;18984158;19106111;19332556;19413330;19564402;19651622;19664994;19801658;20038530;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21311021;21406692;21450806;21559454;21593607;22072790;22190735;22195017;22916032;22944664;23186163;23439679;23481700;23482395;2388630;24424021;24550520;2470644;24715725;24870230;25418920;25505266;25525153;25576301;25640237;25849199;25969445;26154972;26237581;27114305;27397612;27846572;27920218;28115465;28218747;28228285;28510447;28832583;28904123;29242379;29493099;29508533;29557506;29632711;29786170;30315122;30454648;30524438;31844290;31848261;31937595;32157095;32387766;32502341;32938616;33123756;33141586;33298915;33691108;33936100;33968037;34171305;34211107;35051231;35580925;39894887;6930639;7759547;7828588;9037013;9482744;9512417;9630247;9660920",
        "class_list": "",
        "function": "A pull-down assay further suggested the presence of a second K-turn in SL12. Based on the present results, together with available data, we discuss a structural basis for recognition of K-turn motifs in PhopRNA by PhoRpp38., [RefSeq, PubMed]; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPY0;D3DRT8;Q53F71;Q8NHS8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0033204 ribonuclease P RNA binding",
        "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P78345-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N573-1",
        "uniprot_id": [
            {
                "id": "OXR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N573",
                "type": "external"
            }
        ],
        "mass": 97970.0,
        "length": 874,
        "protein_name": "Oxidation resistance protein 1",
        "gene_name": "OXR1",
        "organism": "Human",
        "refseq_name": "oxidation resistance protein 1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001185461",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185461",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OXR1; Nbla00307",
        "gene_names_refseq": "CHEGDD; Nbla00307; OXR1; TLDC3",
        "protein_names_uniprotkb": "Oxidation resistance protein 1",
        "protein_names_refseq": "TBC/LysM-associated domain containing 3; oxidation resistance protein 1 isoform 3; oxidation resistance protein 1; putative protein product of Nbla00307",
        "tax_id": 9606,
        "disease": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (Disease Ontology:DOID:0070339)",
        "pathway": " (hsa:55074)",
        "pathway_count": 1,
        "publication_count": 75,
        "publication_id_list": "10.1101/2023.09.13.557529;11114193;11237011;12880961;15060142;16964243;17081983;17391516;18669648;19690332;20068231;21406692;22873401;23186163;23301498;23481700;24275569;24366607;25576301;25645385;26992070;27846572;27920218;28218747;28228285;28657654;28832583;28834231;28904123;29242379;29314611;29393594;29508533;29557506;29632711;30429286;30524438;31154438;31217245;31530632;31785787;31844290;31845986;31848261;32157095;32350084;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33537174;33592498;33936100;33968037;33981976;34087483;34171305;34357683;34509645;35051231;35154160;35318648;35494241;35580925;36010968;36130215;36215666;36241641;36284347;37773136;38212606;38593795",
        "class_list": "",
        "function": "A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment. Publication Status: Online-Only, [RefSeq, PubMed]; A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish., [RefSeq, PubMed]; Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage., [RefSeq, PubMed]; Human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage (PubMed:11114193, PubMed:15060142). Protects neuronal cells from oxidative stress (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; May be involved in protection from oxidative damage., [UniProtKB, UniProtKB]; OXR1 maintains the retromer to delay brain aging under dietary restriction. Publication Status: Online-Only, [RefSeq, PubMed]; Oxidation resistance 1 prevents genome instability through maintenance of G2/M arrest in gamma-ray-irradiated cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NK11;A8KA34;B3KXL1;B7Z402;B7Z8N5;D3HIS6;Q3LIB5;Q6ZVK9;Q8N8V0;Q9H266;Q9NWC7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006979 response to oxidative stress",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q8N573-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12755-1",
        "uniprot_id": [
            {
                "id": "SKI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12755",
                "type": "external"
            }
        ],
        "mass": 80005.0,
        "length": 728,
        "protein_name": "Ski oncogene",
        "gene_name": "SKI",
        "organism": "Human",
        "refseq_name": "ski oncogene",
        "refseq_ac": [
            {
                "id": "NP_003027",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003027",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SKI",
        "gene_names_refseq": "SGS; SKI; SKV",
        "protein_names_uniprotkb": "Ski oncogene; Proto-oncogene c-Ski",
        "protein_names_refseq": "Sloan-Kettering Institute proto-oncogene; proto-oncogene c-Ski; ski oncogene; ski oncoprotein; v-ski avian sarcoma viral oncogene homolog",
        "tax_id": 9606,
        "disease": "craniosynostosis (Disease Ontology:DOID:2340)",
        "pathway": " (hsa:6497);  (R-HSA-201451);  (R-HSA-2173795)",
        "pathway_count": 3,
        "publication_count": 111,
        "publication_id_list": "10.1101/2023.09.13.557529;10197981;10199400;10458166;10485843;10531062;10535941;10549282;10587642;10587654;10712517;11016919;11121043;11158580;11278251;11389444;11427533;11509558;11571290;11714695;11779505;12151385;12519765;12592392;12821673;12857866;12874272;15820681;16156666;16672363;16751101;16751102;17029022;17068149;17311849;17356069;17438144;17510063;17591695;17592128;18568018;19049980;19135894;19413330;19690332;19875456;19917253;21095583;22045334;23023332;23103230;23186163;24357594;24715725;24736733;25576301;26992070;27153775;27397612;2762147;27846572;27862975;27869121;28657654;28832583;29242379;29351928;29557506;29577978;30429286;30779550;31154438;31530632;31844290;31848261;32157095;32161166;32387766;32488085;32897882;32938616;32938750;32983136;33123756;33141586;33392160;33592498;33691108;33936100;33968037;33981976;34087483;34171305;34211107;35051231;35580925;36241641;36284347;37129290;37217939;37340703;37697026;40307207;40596516;7644468;7791754;8119126;8653785;8893010;9136927;9436979",
        "class_list": "",
        "function": "May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling., [UniProtKB, PubMed]; Nucleotide substitutions at the p.Gly117 and p.Thr180 mutational hot-spots of SKI alter molecular dynamics and may affect cell cycle., [RefSeq, PubMed]; This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]., [RefSeq]; Triplications of chromosome 1p36.3, including the genes GABRD and SKI, are associated with a developmental disorder and a facial gestalt., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SYT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046811 histone deacetylase inhibitor activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:0043585 nose morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "P12755-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N307-1",
        "uniprot_id": [
            {
                "id": "MUC20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N307",
                "type": "external"
            }
        ],
        "mass": 71982.0,
        "length": 709,
        "protein_name": "Mucin-20",
        "gene_name": "MUC20",
        "organism": "Human",
        "refseq_name": "mucin-20 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001269435",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269435",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC20; KIAA1359; PRO7170",
        "gene_names_refseq": "MUC-20; MUC20",
        "protein_names_uniprotkb": "Mucin-20; MUC-20",
        "protein_names_refseq": "mucin-20 isoform a precursor; transmembrane mucin MUC20S",
        "tax_id": 9606,
        "disease": "IgA glomerulonephritis (Disease Ontology:DOID:2986)",
        "pathway": " (hsa:200958);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-8851805);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 8,
        "publication_count": 92,
        "publication_id_list": "10.1038/emboj.2013.79;10330415;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11606584;11821425;12147692;12464682;12855678;12975309;1329093;14565953;14656219;14684163;15314156;15466199;15486459;15560372;15599692;15620693;15687324;16151858;16251947;16319059;16508246;16997931;17050534;17113861;18490740;18537974;18776906;18818202;18834073;19617566;21880719;22041900;22183981;22461326;23053572;23507963;23584533;23602766;2373995;24643043;24715725;25153226;25576301;26992070;28832583;29557506;29789417;30459171;30779550;31154438;31844290;31848261;31898364;33123756;33620575;34087483;34651428;35065708;35166958;35580925;36284347;7513258;7655172;7708691;7731718;8333853;8598452;8611500;8703035;8920913;8972730;9038378;9042338;9070211;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus., [RefSeq, PubMed]; Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO., [RefSeq, PubMed]; Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer., [RefSeq, PubMed]; Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer., [RefSeq, PubMed]; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression., [UniProtKB, PubMed]; Mucin 20 modulates proteasome capacity through c-Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Reflux laryngitis is associated with down-regulation of mucin gene expression., [RefSeq, PubMed]; Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway., [RefSeq, PubMed]; This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 12,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 12,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UX97;Q76I83;Q76I85;Q86ST8;Q8NBY6;Q96KA1;Q9P2I8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0048012 hepatocyte growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q8N307-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NX02-1",
        "uniprot_id": [
            {
                "id": "NALP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NX02",
                "type": "external"
            }
        ],
        "mass": 120515.0,
        "length": 1062,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 2",
        "gene_name": "NLRP2",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001167552",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167552",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP2; NALP2; NBS1; PAN1; PYPAF2",
        "gene_names_refseq": "CLR19.9; NALP2; NBS1; NLRP2; OZEMA18; PAN1; PYPAF2",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 2 isoform 1; NACHT, LRR and PYD domains-containing protein 2; NACHT, leucine rich repeat and PYD containing 2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; nucleotide-binding site protein 1",
        "tax_id": 9606,
        "disease": "oocyte/zygote/embryo maturation arrest 18 (MONDO:MONDO:0957230)",
        "pathway": " (hsa:55655)",
        "pathway_count": 1,
        "publication_count": 76,
        "publication_id_list": "11237011;11250163;11270363;12019269;15030775;15456791;15817483;17178784;17431422;18056399;21406692;23186163;23481700;24366607;24714562;24715725;25418920;25548167;25576301;25880248;25892735;26154972;26728094;26754738;26811146;26929215;27846572;27893789;27920218;28063628;28218747;28832583;28904123;29093164;29242379;29331515;29393594;29437277;29508533;29632046;29786170;30315122;30410026;30620550;30779550;30833945;30877238;31530632;31844290;31848261;32157095;32265295;32350084;32357974;32387766;32502341;32938616;33020905;33141586;33298915;33537174;33717175;33912179;33936100;33981976;34171305;34357683;34932366;35051231;35154160;35580925;36241641;37148315;38633264;39052836;39178021",
        "class_list": "",
        "function": "Functions as a modulator of the activation of NF-kappaB and pro-caspase-1 in macrophages, [RefSeq, PubMed]; HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis., [RefSeq, PubMed]; Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis. Publication Status: Online-Only, [RefSeq, PubMed]; PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins, [RefSeq, PubMed]; Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases., [UniProtKB, PubMed]; These findings provide molecular insight into the expression of NLRP2 by NF-kappaB. GeneRIF: Observational study of genotype prevalence. (HuGE Navigator), [RefSeq, PubMed]; This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]., [RefSeq]; Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrest., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZL7;I3L0G4;Q53FL5;Q59G09;Q8IXT0;Q9BVN5;Q9H6G6;Q9HAV9;Q9NWK3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0032090 Pyrin domain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex",
        "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q9NX02-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13228-1",
        "uniprot_id": [
            {
                "id": "SBP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13228",
                "type": "external"
            }
        ],
        "mass": 52391.0,
        "length": 472,
        "protein_name": "Methanethiol oxidase",
        "gene_name": "SELENBP1",
        "organism": "Human",
        "refseq_name": "methanethiol oxidase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001245217",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245217",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELENBP1; SBP",
        "gene_names_refseq": "EHMTO; HEL-S-134P; LPSB; MTO; SBP56; SELENBP1; SP56; hSBP",
        "protein_names_uniprotkb": "Methanethiol oxidase; 1.8.3.4; 56 kDa selenium-binding protein; MTO; SBP56; SP56; Selenium-binding protein 1",
        "protein_names_refseq": "56 kDa selenium-binding protein; epididymis secretory sperm binding protein Li 134P; methanethiol oxidase isoform 2; methanethiol oxidase",
        "tax_id": 9606,
        "disease": "glaucoma (Disease Ontology:DOID:1686); extraoral halitosis due to methanethiol oxidase deficiency (MONDO:MONDO:0029144)",
        "pathway": " (hsa:8991)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;14991897;16223876;16380993;16645984;19118533;20068231;20112406;23301498;24126823;24275569;25576301;29255262;29393594;29557506;29789417;30379171;31154438;31844290;31848261;32157095;32161166;32938616;34185709;35051231;35580925;36215666;36512497;37437449;37606338;37684566;38518851;9027582;9679983",
        "class_list": "",
        "function": "Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; SBP1 promotes tumorigenesis of thyroid cancer through TXN/NIS pathway. Publication Status: Online-Only, [RefSeq, PubMed]; SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia., [RefSeq, PubMed]; Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4., [RefSeq, PubMed]; Selenium-binding protein 1 (SELENBP1) is a copper-dependent thiol oxidase., [RefSeq, PubMed]; Selenium-binding protein 1 inhibits malignant progression and induces apoptosis via distinct mechanisms in non-small cell lung cancer., [RefSeq, PubMed]; This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NML9;A6PVW9;B2RDR3;B4DKP6;B4E1F3;Q49AQ8;Q96GX7",
        "ec_number_list": [
            {
                "id": "1.8.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008430 selenium binding;GO:0018549 methanethiol oxidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q13228-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16435-1",
        "uniprot_id": [
            {
                "id": "NCPR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16435",
                "type": "external"
            }
        ],
        "mass": 76690.0,
        "length": 677,
        "protein_name": "NADPH--cytochrome P450 reductase",
        "gene_name": "POR",
        "organism": "Human",
        "refseq_name": "NADPH--cytochrome P450 reductase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001354491",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001354491",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POR; CYPOR",
        "gene_names_refseq": "CPR; CYPOR; P450R; POR",
        "protein_names_uniprotkb": "NADPH--cytochrome P450 reductase; 1.6.2.4; CPR; P450R",
        "protein_names_refseq": "NADPH--cytochrome P450 reductase isoform 1; NADPH--cytochrome P450 reductase; NADPH--hemoprotein reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase",
        "tax_id": 9606,
        "disease": "Antley-Bixler syndrome with disordered steroidogenesis (Disease Ontology:DOID:0050462); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cytochrome P450 oxidoreductase deficiency (Disease Ontology:DOID:0080925)",
        "pathway": " (hsa:5447);  (R-HSA-211897)",
        "pathway_count": 2,
        "publication_count": 82,
        "publication_id_list": "10.1101/2023.09.13.557529;10048323;11237011;12381719;14758361;15220035;15264278;15483095;1550342;18838505;19483672;21808038;23186163;23353702;2513880;25645385;25880248;26375851;26811146;26853435;26992070;27452731;27600516;27610946;27862975;27920218;28218747;28228285;28510447;28514659;28649982;28832583;28904123;29242379;29314611;29393594;29437277;29508533;29557506;29632046;29741879;29786170;29789417;30379171;30410026;30573663;30833945;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32488085;32502341;32897882;32938616;32983136;33043033;33091337;33214551;33592498;33717175;33968037;34087483;34171305;34357683;34561969;35051231;35083852;35251023;35561310;35580925;36215666;36241641;36284347;36951964;37509119;37517692;38665916;40914422",
        "class_list": "",
        "function": "Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain., [RefSeq, PubMed]; Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation., [RefSeq, PubMed]; Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Structural, enzymatic and clinical implications of the NADPH P450 oxidoreductase mutations linked to newly identified disorders in humans, now categorized as POR deficiency[review]. Review article, [RefSeq, PubMed]; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16455;Q197M5;Q8N181;Q9H3M8;Q9UDT3",
        "ec_number_list": [
            {
                "id": "1.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0009055 electron transfer activity;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0050660 flavin adenine dinucleotide binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007584 response to nutrient;GO:0043066 negative regulation of apoptotic process;GO:0019395 fatty acid oxidation;GO:0032332 positive regulation of chondrocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "P16435-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WXR4-1",
        "uniprot_id": [
            {
                "id": "MYO3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WXR4",
                "type": "external"
            }
        ],
        "mass": 151829.0,
        "length": 1341,
        "protein_name": "Myosin-IIIb",
        "gene_name": "MYO3B",
        "organism": "Human",
        "refseq_name": "myosin-IIIb isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001077084",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077084",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO3B",
        "gene_names_refseq": "MYO3B",
        "protein_names_uniprotkb": "Myosin-IIIb; 2.7.11.1",
        "protein_names_refseq": "myosin-IIIb isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140469);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 31,
        "publication_id_list": "10025409;10821263;11163272;11237011;11991710;17344846;23481700;24715725;25418920;25645385;25880248;26785147;27582493;28218747;28649982;28832583;28904123;29242379;29437277;29508533;29786170;30315122;31217245;31530632;31844290;31848261;31998317;32357974;32502341;35051231;37340703",
        "class_list": "",
        "function": "MYO3A is more efficient than MYO3B at increasing formation and elongation of stable microvilli on the surface of cultured epithelial cells., [RefSeq, PubMed]; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments., [UniProtKB, UniProtKB]; The structures of Myo3 in complex with Espin1 not only elucidate the mechanism of the binding, but also reveal a Myo3-induced release of Espin1 auto-inhibition mechanism. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZR2;Q53QE1;Q53T08;Q8IX64;Q8IX65;Q8IX66;Q8IX67;Q8IX68;Q96N94",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003779 actin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0000146 microfilament motor activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0032433 filopodium tip;GO:0032426 stereocilium tip;GO:0016459 myosin complex",
        "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0051491 positive regulation of filopodium assembly;GO:0090103 cochlea morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q8WXR4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UK17-1",
        "uniprot_id": [
            {
                "id": "KCND3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UK17",
                "type": "external"
            }
        ],
        "mass": 73451.0,
        "length": 655,
        "protein_name": "A-type voltage-gated potassium channel KCND3",
        "gene_name": "KCND3",
        "organism": "Human",
        "refseq_name": "A-type voltage-gated potassium channel KCND3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004971",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004971",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCND3",
        "gene_names_refseq": "BRGDA9; KCND3L; KCND3S; KCND3; KSHIVB; KV4.3; SCA19; SCA22",
        "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3",
        "protein_names_refseq": "A-type voltage-gated potassium channel KCND3 isoform 1; A-type voltage-gated potassium channel KCND3; potassium channel, voltage gated Shal related subfamily D, member 3; potassium ionic channel Kv4.3; potassium voltage-gated channel long; potassium voltage-gated channel, Shal-related subfamily, member 3; sha1-related potassium channel Kv4.3; voltage-gated K+ channel; voltage-gated potassium channel subunit Kv4.3",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 19/22 (Disease Ontology:DOID:0050970); Brugada syndrome 9 (Disease Ontology:DOID:0110226)",
        "pathway": " (hsa:3752);  (R-HSA-1296072);  (R-HSA-5576894)",
        "pathway_count": 3,
        "publication_count": 32,
        "publication_id_list": "10200233;10676964;10729221;11423117;12297301;12829703;14980207;15358149;16959974;17057713;17187064;17287340;19213956;20393197;21231794;21349352;22198508;22457051;23280837;23280838;24715725;28218747;28895081;29393594;29557506;29632046;32502341;32709127;32818936;34067185;34997220;9843794",
        "class_list": "",
        "function": "A Novel Gain-of-Function KCND3 Variant Associated with Brugada Syndrome., [RefSeq, PubMed]; Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies. Publication Status: Online-Only, [RefSeq, PubMed]; Novel KCND3 Variant Underlying Nonprogressive Congenital Ataxia or SCA19/22 Disrupt KV4.3 Protein Expression and K+ Currents with Variable Effects on Channel Properties. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed:10200233, PubMed:17187064, PubMed:21349352, PubMed:22457051, PubMed:23280837, PubMed:23280838, PubMed:34997220, PubMed:9843794). Channel properties are modulated by interactions with regulatory subunits (PubMed:17187064, PubMed:34997220). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:17187064, PubMed:34997220). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (PubMed:34997220)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60576;O60577;Q14D71;Q5T0M0;Q9UH85;Q9UH86;Q9UK16",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0046872 metal ion binding;GO:0005250 A-type (transient outward) potassium channel activity",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0045211 postsynaptic membrane",
        "go_biological_process": "GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0099625 ventricular cardiac muscle cell membrane repolarization;GO:0006936 muscle contraction;GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9UK17-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RI1-3",
        "uniprot_id": [
            {
                "id": "NR1H4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RI1",
                "type": "external"
            }
        ],
        "mass": 55914.0,
        "length": 486,
        "protein_name": "Bile acid receptor",
        "gene_name": "NR1H4",
        "organism": "Human",
        "refseq_name": "bile acid receptor isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001193906",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193906",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NR1H4; BAR; FXR; HRR1; RIP14",
        "gene_names_refseq": "BAR; FXR; HRR-1; HRR1; NR1H4; PFIC5; RIP14",
        "protein_names_uniprotkb": "Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; RXR-interacting protein 14; Retinoid X receptor-interacting protein 14",
        "protein_names_refseq": "RXR-interacting protein 14; bile acid receptor isoform 1; bile acid receptor; farnesoid X nuclear receptor; farnesoid X-activated receptor; farnesol receptor HRR-1; retinoid X receptor-interacting protein 14",
        "tax_id": 9606,
        "disease": "progressive familial intrahepatic cholestasis 5 (Disease Ontology:DOID:0070225); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:9971);  (R-HSA-159418);  (R-HSA-192105);  (R-HSA-193368);  (R-HSA-193807);  (R-HSA-1989781);  (R-HSA-211976)",
        "pathway_count": 7,
        "publication_count": 159,
        "publication_id_list": "10051404;10092594;10334992;10334993;10358072;10479480;10514450;10588945;10601278;10655068;10749848;10777541;10884298;10987286;11060344;11067870;11158055;11159893;11267664;11387316;11555828;11579204;11673457;11802775;11870371;11927623;11980911;12016314;12062799;12118000;12177166;12220224;12393883;12404239;12404240;12486725;12505311;12554753;12582161;12660231;12663868;12679481;12704183;12718892;12718893;12754200;12806625;12815072;12891557;13416382;1400444;14684751;14699511;15042513;15067378;15130092;15187081;15202934;15239098;15337761;15471871;15635043;15911693;16269519;16317684;16380219;16541101;16908160;16946559;16972786;1708392;1741400;17428193;17650074;17681172;17895379;17931734;18391212;18540824;18621523;18668687;18719978;18755856;18848529;19085950;19088433;19159286;19393742;19410460;19556342;19586769;19661213;19710929;19805516;19833092;19864602;19883617;19934321;20095622;20110263;20149798;2019602;2037576;20447400;21242261;21383957;21636783;21804189;22345554;2256920;22772592;22820415;23018617;23235576;23337244;23428468;23462506;23546875;23830809;2384150;23928191;24196956;24209621;24715725;24742681;2592361;26715851;26888176;29557506;3024157;30275017;3038528;31154438;3487786;35580925;38183609;38493698;38641832;38932276;7077161;7508385;7557095;7588781;7649182;7685352;7892212;8034703;8132774;8387517;8619637;8647822;8902629;8943006;9012850;9536209;9578606;9660774;9748239;9852097",
        "class_list": "",
        "function": "Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation., [RefSeq, PubMed]; FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease., [RefSeq, PubMed]; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:12754200, PubMed:15471871, PubMed:17895379). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:10514450, PubMed:15239098, PubMed:16269519). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression (PubMed:12815072, PubMed:19085950). The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (PubMed:12806625, PubMed:16946559). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12554753, PubMed:12660231, PubMed:15337761). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:11927623, PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:21242261). Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (PubMed:19864602). Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes. Publication Status: Online-Only, [RefSeq, PubMed]; NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA., [UniProtKB, PubMed, PubMed]; Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA), NR0B2/SHP (inducible by unconjugated CDCA DCA and ACA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; not inducible by taurine- and glycine-amidated CDCA., [UniProtKB, PubMed]; Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA., [UniProtKB, PubMed]; This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 13,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4K5;B7Z412;B7ZM06;F8VYG8;Q8NFP5;Q8NFP6;Q92943",
        "ec_number_list": [],
        "go_molecular_function": "GO:1902122 chenodeoxycholic acid binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0043235 receptor complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:1904179 positive regulation of adipose tissue development;GO:0032703 negative regulation of interleukin-2 production;GO:0032740 positive regulation of interleukin-17 production;GO:0038185 nuclear receptor-mediated bile acid signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 16.0,
        "record_id": "Q96RI1-3",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75167-1",
        "uniprot_id": [
            {
                "id": "PHAR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75167",
                "type": "external"
            }
        ],
        "mass": 69700.0,
        "length": 634,
        "protein_name": "Phosphatase and actin regulator 2",
        "gene_name": "PHACTR2",
        "organism": "Human",
        "refseq_name": "phosphatase and actin regulator 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001093634",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093634",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHACTR2; C6orf56; KIAA0680",
        "gene_names_refseq": "C6orf56; PHACTR2",
        "protein_names_uniprotkb": "Phosphatase and actin regulator 2",
        "protein_names_refseq": "phosphatase and actin regulator 2 isoform 1",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377)",
        "pathway": " (hsa:9749);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 43,
        "publication_id_list": "11237011;1435334;14630798;15297306;17081983;18077418;18984734;19413330;19429005;19651622;19664994;19913121;23186163;23640497;24275569;25399010;25807930;28228285;28832583;29242379;29557506;29632711;30524438;31154438;31844290;31848261;32157095;32161166;32357974;32938616;32983136;33592498;33968037;34087483;34171305;34932366;35051231;35059740;35580925;36010968;36241641;6457647;8467233",
        "class_list": "",
        "function": "Identified an association between Phactr2 SNP rs11155313 and Parkinson's disease in US, Canadian and Irish patient populations, but not in a Norwegian population GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Rs9390123 and rs9399451 influence the DNA repair capacity of lung cancer by regulating PEX3 and PHACTR2AS1 expression instead of PHACTR2., [RefSeq, PubMed]; The frequencies of genotype and allele in CHRNA3 (rs8040868) and PHACTR2 (rs9390123) were not significantly different between the NSCLC cases and controls, or between either of the subgroups., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKP5;A7MCZ5;A8MZC0;B2RWP7;B4DN76;B4DPB5;B4DTH7;Q5TFA0;Q68DM2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0031092 platelet alpha granule membrane",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "O75167-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BXM0-1",
        "uniprot_id": [
            {
                "id": "PRAX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BXM0",
                "type": "external"
            }
        ],
        "mass": 154905.0,
        "length": 1461,
        "protein_name": "Periaxin",
        "gene_name": "PRX",
        "organism": "Human",
        "refseq_name": "periaxin isoform 1",
        "refseq_ac": [
            {
                "id": "NP_066007",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066007",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRX; KIAA1620",
        "gene_names_refseq": "CMT4F; PRX",
        "protein_names_uniprotkb": "Periaxin",
        "protein_names_refseq": "periaxin isoform 1",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); Charcot-Marie-Tooth disease type 4F (Disease Ontology:DOID:0110193)",
        "pathway": " (hsa:57716);  (R-HSA-9619665)",
        "pathway_count": 2,
        "publication_count": 118,
        "publication_id_list": "10203854;10220111;10400691;10727776;10757804;10856243;11115854;11133365;11157804;11237011;11356866;11394999;11430795;11430802;11734543;11782409;12056842;12145339;12198163;12782656;12799134;14512514;14522948;14664827;15150276;15189448;15356632;15610069;15695336;15836632;15907797;16136673;16311519;16319321;16373334;16923174;1704008;17081983;17325040;17699610;17959798;18634568;18803322;19143832;19156870;19321787;19562805;19745155;1975954;19922439;20149798;20213556;20625412;20832498;21044070;21326363;21411665;21423190;21423191;21613327;21653862;22053691;22180461;22333914;22492709;22764250;22814607;22847150;23695165;23747866;23874858;24191038;24227709;24627108;24633211;24646194;24675079;24715725;25576301;25645385;25974668;26059842;26423937;26441514;26940996;27081207;27220739;27288457;27859941;27862975;28852375;29557506;29748249;30429286;31092671;31154438;31222486;31848261;32157095;32938616;33298915;35051231;36215666;36241641;7925941;7935840;8138712;8349731;8619637;8627307;8647822;8662541;8842374;9418958;9482253;9705348;9748295;9858769",
        "class_list": "",
        "function": "Results offer a possible mechanism to the formation of periaxin complexes, improvement of complex stability, and establishment of a link between the extracellular matrix and the cytoskeleton, [RefSeq, PubMed]; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology., [UniProtKB, UniProtKB]; The study identified a variant of periaxin in a Chinese family with congenital cataract by exome sequencing., [RefSeq, PubMed]; This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. [provided by RefSeq, Jul 2008]., [RefSeq]; We were able to simplify this complex phenotype and identified a causative mutation (p.R1070*) in the gene periaxin (PRX), a gene previously shown to cause peripheral neuropathy (Dejerine-Sottas syndrome) when this mutation is present, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 12,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BXL9;Q9HCF2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0070161 anchoring junction",
        "go_biological_process": "GO:0032287 peripheral nervous system myelin maintenance;GO:0043484 regulation of RNA splicing;GO:0008366 axon ensheathment",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "Q9BXM0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30874-1",
        "uniprot_id": [
            {
                "id": "SSR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30874",
                "type": "external"
            }
        ],
        "mass": 41333.0,
        "length": 369,
        "protein_name": "Somatostatin receptor type 2",
        "gene_name": "SSTR2",
        "organism": "Human",
        "refseq_name": "somatostatin receptor type 2",
        "refseq_ac": [
            {
                "id": "NP_001041",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SSTR2",
        "gene_names_refseq": "SST2; SSTR2",
        "protein_names_uniprotkb": "Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2-R; SS2R; SST2",
        "protein_names_refseq": "SRIF-1; SS2R; somatostatin receptor type 2",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:6752);  (R-HSA-375276);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 126,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10551867;10604470;10619399;10854085;10899166;11007482;11322507;11385580;11457843;11562423;11683476;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15231824;15539556;1567413;15947423;15951850;1655761;16634148;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18577758;18653781;19434240;20025498;22495673;22932785;23446738;23690594;24565897;24715725;24906252;2534964;2649896;2748346;27496565;2834384;31848261;3202875;32350084;3366244;33968037;35051231;35154160;3525564;37223009;37716507;38036157;38374188;3856870;39197921;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8386508;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Epigenetic regulation of SST2 expression in small intestinal neuroendocrine tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Expression Analysis of SSTR 1, 2 and 3 in Small-cell Lung Cancer Patients as Targets for Future Peptide Receptor Radionuclide Therapy., [RefSeq, PubMed]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment., [RefSeq, PubMed]; Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]., [RefSeq]; Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Somatostatin receptor2 (SSTR2) expression, prognostic implications, modifications and potential therapeutic strategies associates with head and neck squamous cell carcinomas. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3Y0;B2R9P7;Q4VBP0;Q96GE0;Q96TF2;Q9BWH1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0030165 PDZ domain binding;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0071392 cellular response to estradiol stimulus;GO:0071385 cellular response to glucocorticoid stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "P30874-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96GP6-1",
        "uniprot_id": [
            {
                "id": "SREC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96GP6",
                "type": "external"
            }
        ],
        "mass": 92384.0,
        "length": 871,
        "protein_name": "Scavenger receptor class F member 2",
        "gene_name": "SCARF2",
        "organism": "Human",
        "refseq_name": "scavenger receptor class F member 2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_699165",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_699165",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCARF2; SREC2; SREPCR",
        "gene_names_refseq": "NSR1; SCARF2; SREC-II; SREC2; SRECRP-1; VDEGS",
        "protein_names_uniprotkb": "Scavenger receptor class F member 2; SREC-II; SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein",
        "protein_names_refseq": "scavenger receptor class F member 2 isoform 1 precursor; scavenger receptor expressed by endothelial cells 2 protein",
        "tax_id": 9606,
        "disease": "Van den Ende-Gupta syndrome (Disease Ontology:DOID:0111699)",
        "pathway": " (hsa:91179)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "12154095;16959974;20887961;21406692;23481700;24275569;24478002;29557506;31844290;31848261;33592498;33783941;35051231;35224863",
        "class_list": "",
        "function": "Further delineation of van den Ende-Gupta syndrome: Genetic heterogeneity and overlap with congenital heart defects and skeletal malformations syndrome., [RefSeq, PubMed]; Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome., [RefSeq, PubMed]; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity)., [UniProtKB]; SRECII binds to SRECI and has a similar tissue distribution pattern, [RefSeq, PubMed]; The full VDEGS phenotype may include sclerocornea resulting from homozygosity or compound heterozygosity for loss of function variants in SCARF2., [RefSeq, PubMed]; The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]; Two novel variants in SCARF2 gene underlie van den Ende-Gupta syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E5RFB8;Q58A83;Q8IXF3;Q9BW74",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005044 scavenger receptor activity",
        "go_cellular_component": "GO:0005925 focal adhesion;GO:0016020 membrane",
        "go_biological_process": "GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96GP6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15455-1",
        "uniprot_id": [
            {
                "id": "TLR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15455",
                "type": "external"
            }
        ],
        "mass": 103829.0,
        "length": 904,
        "protein_name": "Toll-like receptor 3",
        "gene_name": "TLR3",
        "organism": "Human",
        "refseq_name": "toll-like receptor 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_003256",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003256",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TLR3",
        "gene_names_refseq": "CD283; IIAE2; IMD83; TLR3",
        "protein_names_uniprotkb": "Toll-like receptor 3",
        "protein_names_refseq": "toll-like receptor 3 precursor",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colitis (Disease Ontology:DOID:0060180); critical COVID-19 (Disease Ontology:DOID:0081012); severe COVID-19 (Disease Ontology:DOID:0081013); pre-eclampsia (Disease Ontology:DOID:10591); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); anogenital venereal wart (Disease Ontology:DOID:11168); Behcet's disease (Disease Ontology:DOID:13241); colon carcinoma (Disease Ontology:DOID:1520); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); eye disease (Disease Ontology:DOID:5614); peripheral nervous system disease (Disease Ontology:DOID:574); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 1 diabetes mellitus (Disease Ontology:DOID:9744); immunodeficiency 83, susceptibility to viral infections (MONDO:MONDO:0800187)",
        "pathway": " (hsa:7098);  (R-HSA-1679131);  (R-HSA-168164);  (R-HSA-168927);  (R-HSA-1810476);  (R-HSA-5602410);  (R-HSA-5602415);  (R-HSA-5602566);  (R-HSA-5602571);  (R-HSA-9013957);  (R-HSA-9013973);  (R-HSA-9014325);  (R-HSA-9828211);  (R-HSA-9833110)",
        "pathway_count": 14,
        "publication_count": 166,
        "publication_id_list": "10.1101/2023.09.13.557529;10702308;10723127;11057907;11237011;11607032;12181749;12221085;12242293;12471095;12539043;12609980;12620240;12692549;12752666;12855817;14517278;14555995;14703513;14716310;14739303;14976261;15064760;15145317;15210742;15226270;15327770;15340161;15814722;15961631;16043704;16056267;16115877;16144834;16186825;16260493;16306936;16306937;16415873;16547522;16603398;16720699;16857668;16858407;16964262;16973841;17047224;17085778;17135271;17157040;17178723;17275357;17327220;17452530;17496917;17526488;17599067;17872438;18082565;18166152;18172197;18305481;18420935;18452278;18509083;18753640;18810425;18820679;18931679;18941233;19079358;19112497;19159218;19278658;19451267;19590578;19666475;19675569;19898473;19965672;20047764;20058876;20308068;20410276;20696886;20832341;20855885;20865800;21398612;21402738;21604257;21737329;21737330;21862579;21911422;21931591;22090124;22105173;22123964;22164301;22174453;22223641;22421964;22579623;22611194;23103873;23453969;23453971;23453972;23481700;24190977;24526685;24715725;25736436;25854864;27226571;27538435;27701768;28218747;28514659;28832583;28904123;29242379;29383749;29393594;29437277;29557506;29636491;29769354;29786170;30833945;31076723;31154438;31844290;32157095;32265295;32387766;32488085;32878999;32938616;32972995;33141586;33298915;33432245;33592498;33968037;34185709;34357683;34494836;35051231;35289036;35580925;36010968;36102648;36936901;37074911;37158982;38551071;38864429;38868969;38907187;39259342;8344253;9435236;9566918;9799232",
        "class_list": "",
        "function": "Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil., [RefSeq, PubMed]; Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study. Publication Status: Online-Only, [RefSeq, PubMed]; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]., [RefSeq]; UPK3A[+] umbrella cell damage mediated by TLR3-NR2F6 triggers programmed destruction of urothelium in Hunner-type interstitial cystitis/painful bladder syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 15,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 11,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 15,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 15,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 35,
        "disease_count": 26,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAI7;B7Z7K0;E6Y0F0;E6Y0F1;E9PGH4;Q4VAL2;Q504W0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0038187 pattern recognition receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 21.8,
        "record_id": "O15455-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RL7-1",
        "uniprot_id": [
            {
                "id": "VP13A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RL7",
                "type": "external"
            }
        ],
        "mass": 360276.0,
        "length": 3174,
        "protein_name": "Intermembrane lipid transfer protein VPS13A",
        "gene_name": "VPS13A",
        "organism": "Human",
        "refseq_name": "intermembrane lipid transfer protein VPS13A isoform C",
        "refseq_ac": [
            {
                "id": "NP_001018047",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018047",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VPS13A; CHAC; KIAA0986",
        "gene_names_refseq": "BLTP5A; CHAC; CHOREIN; VPS13A",
        "protein_names_uniprotkb": "Intermembrane lipid transfer protein VPS13A; Chorea-acanthocytosis protein; Chorein; Vacuolar protein sorting-associated protein 13A",
        "protein_names_refseq": "bridge-like lipid transfer protein family member 5A; chorea-acanthocytosis protein; intermembrane lipid transfer protein VPS13A isoform C; intermembrane lipid transfer protein VPS13A; vacuolar protein sorting 13A; vacuolar protein sorting-associated protein 13A",
        "tax_id": 9606,
        "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); choreaacanthocytosis (Disease Ontology:DOID:0050766); Parkinson's disease 23 (Disease Ontology:DOID:0060896); Cohen syndrome (Disease Ontology:DOID:0111590); autosomal recessive spinocerebellar ataxia 4 (Disease Ontology:DOID:0111611); choreatic disease (Disease Ontology:DOID:12859); Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:23230)",
        "pathway_count": 1,
        "publication_count": 120,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11381253;11381254;12404112;15498460;16959974;18452278;18669648;20068231;21598378;21872626;21993680;22424782;23186163;23481700;24366607;24714562;24715725;25418920;25576301;25645385;25880248;25892735;26024233;26154972;26375851;26728094;26811146;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29741879;29769354;29786170;30093493;30192525;30315122;30410026;30429286;30484775;30524438;30709847;30741634;30779550;30833945;31086825;31092671;31154438;31192303;31217245;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32845802;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;34830155;34846842;34932366;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37209156;37670483;37744224;37938771;39324427",
        "class_list": "",
        "function": "An Autopsy Series of Seven Cases of VPS13A Disease (Chorea-Acanthocytosis)., [RefSeq, PubMed]; Chorein sensitive microtubule organization in tumor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical Features and Novel Pathogenic Variants of Chinese Patients With McLeod Syndrome and Chorea-Acanthocytosis., [RefSeq, PubMed]; Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s)., [RefSeq, PubMed]; Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids (PubMed:34830155). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 78,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JSX9;Q5JSY0;Q5VYR5;Q702P4;Q709D0;Q86YF8;Q96S61;Q9H995;Q9Y2J1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005829 cytosol",
        "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006869 lipid transport;GO:0006914 autophagy;GO:0008104 intracellular protein localization;GO:0006895 Golgi to endosome transport",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "Q96RL7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.001000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00294-1",
        "uniprot_id": [
            {
                "id": "TULP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00294",
                "type": "external"
            }
        ],
        "mass": 60609.0,
        "length": 542,
        "protein_name": "Tubby-related protein 1",
        "gene_name": "TULP1",
        "organism": "Human",
        "refseq_name": "tubby-related protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001276324",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276324",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TULP1; TUBL1",
        "gene_names_refseq": "LCA15; RP14; TUBL1; TULP1",
        "protein_names_uniprotkb": "Tubby-related protein 1; Tubby-like protein 1",
        "protein_names_refseq": "tubby like protein 1; tubby-related protein 1 isoform 2; tubby-related protein 1",
        "tax_id": 9606,
        "disease": "Leber congenital amaurosis 15 (Disease Ontology:DOID:0110189); retinitis pigmentosa 14 (Disease Ontology:DOID:0110381); retinitis pigmentosa (Disease Ontology:DOID:10584); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:7287)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;15024725;15557452;16303976;17620573;17962469;19837063;24715725;27440997;29557506;31844290;33907372;33936100;33981976;34865612;35051231;36128853;37217939;9096357;9462750;9462751;9660588",
        "class_list": "",
        "function": "A novel homozygous missense mutation p.P388S in TULP1 causes protein instability and retinitis pigmentosa. Publication Status: Online-Only, [RefSeq, PubMed]; Natural history and biomarkers of retinal dystrophy caused by the biallelic TULP1 variant c.148delG., [RefSeq, PubMed]; Pathogenic mutations in TULP1 are responsible for the retinitis pigmentosa phenotype in seven familial cases with a common ancestral mutation responsible for the disease phenotype in four of the seven families. Publication Status: Online-Only, [RefSeq, PubMed]; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages., [UniProtKB, PubMed, PubMed]; TULP1 related retinal dystrophy: report of rare and novel variants with a previously undescribed phenotype in two cases., [RefSeq, PubMed]; This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. The protein encoded by this gene is thought to play a role in the physiology of photoreceptors. Mutations in this gene are associated with recessive juvenile retinitis pigmentosa and Leber congenital amaurosis-15. [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43536;Q5TGM5;Q8N571",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043679 axon terminus",
        "go_biological_process": "GO:0016358 dendrite development;GO:0006909 phagocytosis;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0001895 retina homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "O00294-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P47893-1",
        "uniprot_id": [
            {
                "id": "OR3A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P47893",
                "type": "external"
            }
        ],
        "mass": 35207.0,
        "length": 321,
        "protein_name": "Olfactory receptor 3A2",
        "gene_name": "OR3A2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR3A2; OLFRA04",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 3A2; OR17-228; Olfactory receptor 17-228; Olfactory receptor OR17-14",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4995);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "10673334;11237011;14983052;24800820;27515280;31974307;32066986;8004088",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFM3;Q9P1Q3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007606 sensory perception of chemical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "P47893-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BXJ9-1",
        "uniprot_id": [
            {
                "id": "NAA15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BXJ9",
                "type": "external"
            }
        ],
        "mass": 101272.0,
        "length": 866,
        "protein_name": "N-alpha-acetyltransferase 15, NatA auxiliary subunit",
        "gene_name": "NAA15",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform 1",
        "refseq_ac": [
            {
                "id": "NP_476516",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476516",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA15; GA19; NARG1; NATH; TBDN100",
        "gene_names_refseq": "Ga19; MRD50; NAA15; NARG1; NAT1P; NATH; TBDN100; TBDN",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 15, NatA auxiliary subunit; Gastric cancer antigen Ga19; N-terminal acetyltransferase; NMDA receptor-regulated protein 1; Protein tubedown-1; Tbdn100",
        "protein_names_refseq": "N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform 1; N-terminal acetyltransferase; NMDA receptor regulated 1; NMDA receptor-regulated protein 1; gastric cancer antigen Ga19; protein tubedown-1; transcriptional coactivator tubedown-100",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 50 (Disease Ontology:DOID:0080233); intellectual disability (Disease Ontology:DOID:1059); congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:80155)",
        "pathway_count": 1,
        "publication_count": 92,
        "publication_id_list": "11237011;11687548;12019451;12087473;12140756;12145306;15496142;16507339;16638120;17081983;18452278;18669648;19413330;19608861;19651622;19660095;20068231;20154145;21406692;23186163;23301498;25576301;25880248;25892735;26154972;26375851;26768311;26811146;26992070;27397612;27846572;27920218;28191889;28218747;28228285;28514659;28649982;28904123;29351928;29437277;29557506;29754825;29769354;30315122;30410026;30429286;31154438;31217245;31844290;31848261;32042062;32119511;32157095;32265295;32350084;32357974;32387766;32502341;32870666;32897882;32938616;33141586;33214551;33298915;33392160;33557580;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34357683;34561969;34725712;35051231;35138101;35154160;35251023;35318648;35328089;35494241;35580925;36010968;36241641;37130971;38665916;40307207;40596516;40914422",
        "class_list": "",
        "function": "Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome., [RefSeq, PubMed]; Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency., [RefSeq, PubMed]; N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]., [RefSeq]; NATH, a novel gene overexpressed in papillary thyroid carcinomas., [RefSeq, PubMed]; Possible Catch-Up Developmental Trajectories for Children with Mild Developmental Delay Caused by NAA15 Pathogenic Variants. Review article Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNY6;Q52LG9;Q8IWH4;Q8NEV2;Q9H8P6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0010698 acetyltransferase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016604 nuclear body",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0050821 protein stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q9BXJ9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y619-1",
        "uniprot_id": [
            {
                "id": "ORNT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y619",
                "type": "external"
            }
        ],
        "mass": 32736.0,
        "length": 301,
        "protein_name": "Mitochondrial ornithine transporter 1",
        "gene_name": "SLC25A15",
        "organism": "Human",
        "refseq_name": "mitochondrial ornithine transporter 1",
        "refseq_ac": [
            {
                "id": "NP_055067",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055067",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC25A15; ORC1; ORNT1; SP1855",
        "gene_names_refseq": "D13S327; HHH; LNC-HC; ORC1; ORNT1; SLC25A15",
        "protein_names_uniprotkb": "Mitochondrial ornithine transporter 1; Solute carrier family 25 member 15",
        "protein_names_refseq": "hyperammonemia-hyperornithinemia-homocitrullinuria syndrome; mitochondrial ornithine transporter 1; ornithine carrier 1; ornithine transporter 1; ornithine transporter) member 15; solute carrier family 25 (mitochondrial carrier",
        "tax_id": 9606,
        "disease": "ornithine translocase deficiency (Disease Ontology:DOID:0050720); amino acid metabolic disorder (Disease Ontology:DOID:9252); citrullinemia (Disease Ontology:DOID:9273)",
        "pathway": " (hsa:10166);  (R-HSA-70635);  (R-HSA-9956508)",
        "pathway_count": 3,
        "publication_count": 54,
        "publication_id_list": "10369256;10805333;10813810;11237011;11237854;11355015;11552031;11668643;11814739;12459178;12807890;12859189;12948741;15050968;15498874;16141327;16601889;17407445;17496144;17900240;18263583;18323623;19006241;19242930;19754428;22076378;22262851;2263616;23649895;24703693;24721342;26592762;27862975;28510447;28832583;28904123;29557506;30121301;30403179;30833945;32157095;32938616;34171305;34357683;35051231;38450598;518841;6249820;6372096;7649538;8898077;9256435;9686347;9852088",
        "class_list": "",
        "function": "Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism., [RefSeq, PubMed]; Mitochondrial ornithine-citrulline antiporter (Probable) (PubMed:12807890, PubMed:22262851). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable) (PubMed:12807890, PubMed:22262851). Lysine and arginine are also transported by the antiport mechanism (Probable) (PubMed:12807890). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Overexpression of SLC25A15 is involved in the progression of melanoma and may predict the prognosis of melanoma., [RefSeq, PubMed]; Structure/function relationships of the human mitochondrial ornithine/citrulline carrier by Cys site-directed mutagenesis. Relevance to mercury toxicity., [RefSeq, PubMed]; This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VZD8;Q9HC45",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0000050 urea cycle;GO:1903401 L-lysine transmembrane transport;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1903826 L-arginine transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q9Y619-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86VP3-1",
        "uniprot_id": [
            {
                "id": "PACS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86VP3",
                "type": "external"
            }
        ],
        "mass": 97702.0,
        "length": 889,
        "protein_name": "Phosphofurin acidic cluster sorting protein 2",
        "gene_name": "PACS2",
        "organism": "Human",
        "refseq_name": "phosphofurin acidic cluster sorting protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001094383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PACS2; KIAA0602; PACS1L",
        "gene_names_refseq": "DEE66; EIEE66; PACS-2; PACS1L; PACS2",
        "protein_names_uniprotkb": "Phosphofurin acidic cluster sorting protein 2; PACS-2; PACS1-like protein",
        "protein_names_refseq": "PACS1-like protein; phosphofurin acidic cluster sorting protein 2 isoform 1",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 66 (Disease Ontology:DOID:0080446)",
        "pathway": " (hsa:23241)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "11237011;15692563;15692567;18296443;18417615;19481529;20068231;23186163;24275569;24715725;25576301;27543614;28649982;28657654;28832583;29242379;29393594;29557506;29656858;30379171;30779550;31787984;31844290;32157095;32350084;33298915;33592498;33936100;33968037;33981976;34019948;34405643;34642815;35051231;35580925;35951762;36010968;36241641;38169625;38540691",
        "class_list": "",
        "function": "Characteristics of Developmental and Epileptic Encephalopathy Associated with PACS2 p.Glu209Lys Pathogenic Variant-Our Experience and Systematic Review of the Literature. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells., [RefSeq, PubMed]; MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments., [UniProtKB, PubMed, PubMed]; PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis Erratum:[EMBO J. 2005 Mar 23;24(6):1301], [RefSeq, PubMed]; PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system, [RefSeq, PubMed]; Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action., [RefSeq, PubMed]; Subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2, [RefSeq, PubMed]; The phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane, [RefSeq, PubMed]; [Early infantile epileptic encephalopathy caused by PACS2 gene variation: three cases report and literature review]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2VDJ9;G8JLK3;O60342;Q6P191;Q96FL7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0044325 transmembrane transporter binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0000045 autophagosome assembly;GO:0072659 protein localization to plasma membrane;GO:0006915 apoptotic process;GO:0034497 protein localization to phagophore assembly site;GO:0032469 endoplasmic reticulum calcium ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q86VP3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UI09-1",
        "uniprot_id": [
            {
                "id": "NDUAC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UI09",
                "type": "external"
            }
        ],
        "mass": 17114.0,
        "length": 145,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12",
        "gene_name": "NDUFA12",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001245267",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245267",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFA12; DAP13",
        "gene_names_refseq": "B17.2; DAP13; MC1DN23; NDUFA12",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; 13 kDa differentiation-associated protein; CI-B17.2; CIB17.2; Complex I-B17.2; NADH-ubiquinone oxidoreductase subunit B17.2",
        "protein_names_refseq": "13 kDa differentiation-associated protein; CI-B17.2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform b; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; NADH-ubiquinone oxidoreductase subunit B17.2; complex I B17.2 subunit",
        "tax_id": 9606,
        "disease": "nuclear type mitochondrial complex I deficiency 23 (Disease Ontology:DOID:0112087)",
        "pathway": " (hsa:55967);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 92,
        "publication_id_list": "10327278;10830904;10931946;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17936786;186667;19752196;20406883;20552642;20858599;21617257;21924235;23150584;23270816;23553477;23564345;23747254;239860;24191001;24715725;25418920;25564869;25576301;25645385;25678554;25802875;26375851;26992070;27499296;27626371;27846572;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30192525;30315122;30429286;30779550;31217245;31666358;31844290;31866046;32157095;32161166;32320651;32335026;32357974;32502341;32897882;32938616;32983136;33141586;33592498;33715266;33717175;33879611;33882309;33912179;34087483;34185709;35333655;35561310;35580925;35614220;36010968;36241641;38199007;39894887;4288886;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-) mice and Leigh syndrome patients: A stabilizing role for NDUFAF2., [RefSeq, PubMed]; Novel NDUFA12 variants are associated with isolated complex I defect and variable clinical manifestation., [RefSeq, PubMed]; This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8VQS7;Q53XX0;Q9BRV6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0009060 aerobic respiration;GO:0022904 respiratory electron transport chain",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q9UI09-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16549-1",
        "uniprot_id": [
            {
                "id": "PCSK7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16549",
                "type": "external"
            }
        ],
        "mass": 86247.0,
        "length": 785,
        "protein_name": "Proprotein convertase subtilisin/kexin type 7",
        "gene_name": "PCSK7",
        "organism": "Human",
        "refseq_name": "proprotein convertase subtilisin/kexin type 7 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_004707",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004707",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PCSK7; LPC; PC7; PC8; SPC7",
        "gene_names_refseq": "LPC; PC7; PC8; PCSK7; SPC7",
        "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 7; 3.4.21.-; Lymphoma proprotein convertase; PC7; PC8; Prohormone convertase 7; Proprotein convertase 7; Proprotein convertase 8; Subtilisin/kexin-like protease PC7; hPC8",
        "protein_names_refseq": "lymphoma proprotein convertase; prohormone convertase 7; prohormone convertase PC7; proprotein convertase 7; proprotein convertase 8; proprotein convertase PC7; proprotein convertase subtilisin/kexin type 7 preproprotein; subtilisin/kexin-like protease PC7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9159);  (R-HSA-9768727)",
        "pathway_count": 2,
        "publication_count": 72,
        "publication_id_list": "10.1101/2023.09.13.557529;10362256;11237011;17261850;18452278;18491227;22375065;24190977;24366607;24681004;24714562;24966173;25418920;25502872;25576301;25645385;26154972;26416966;26728094;26811146;27255086;27846572;27893789;27920218;28218747;28228285;28467828;28512129;28832583;29242379;29393594;29437277;29508533;29557506;29632046;30315122;30429286;31217245;31844290;31848261;32157095;32265295;32350084;32387766;32502341;32897882;32938616;32983136;33118184;33141586;33298915;33565643;33592498;33717175;33936100;33968037;34207761;34211107;34357683;34509645;34561969;34876018;34932366;35051231;35154160;35251023;36215666;37392838;7982500;8564950;8615762;9341152",
        "class_list": "",
        "function": "Dysregulation of the LPC-ATX-LPA axis in autoimmune hepatitis is associated with monocyte activation., [RefSeq, PubMed]; Network Medicine Approach in Prevention and Personalized Treatment of Dyslipidemias. Review article, [RefSeq, PubMed]; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway., [UniProtKB]; The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin-Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]., [RefSeq]; Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis., [RefSeq, PubMed]; Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 9606,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ60;Q3C1X1;Q53GM4;Q96FK8;Q9UL57",
        "ec_number_list": [
            {
                "id": "3.4.21.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q16549-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5X2-1",
        "uniprot_id": [
            {
                "id": "SNX8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5X2",
                "type": "external"
            }
        ],
        "mass": 52569.0,
        "length": 465,
        "protein_name": "Sorting nexin-8",
        "gene_name": "SNX8",
        "organism": "Human",
        "refseq_name": "sorting nexin-8",
        "refseq_ac": [
            {
                "id": "NP_037453",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037453",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SNX8",
        "gene_names_refseq": "Mvp1; SNX8",
        "protein_names_uniprotkb": "Sorting nexin-8",
        "protein_names_refseq": "sorting nexin-8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29886)",
        "pathway_count": 1,
        "publication_count": 71,
        "publication_id_list": "11237011;11485546;16959974;18669648;19782049;20112406;23481700;25418920;25576301;25645385;26154972;26375851;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28467828;28510447;28514659;28832583;28834231;28904123;29180417;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30429286;30484775;30524438;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34171305;34185709;34231239;34509645;34524084;34725712;34932366;35051231;35154160;35318648;35561310;35580925;37938771;38519472",
        "class_list": "",
        "function": "A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling. Publication Status: Online-Only, [RefSeq, PubMed]; Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD., [RefSeq, PubMed]; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network., [UniProtKB, PubMed]; SNX8 enables lysosome reformation and reverses lysosomal storage disorder. Publication Status: Online-Only, [RefSeq, PubMed]; SNX8 mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D207;Q96I67",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034498 early endosome to Golgi transport;GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q9Y5X2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P17480-1",
        "uniprot_id": [
            {
                "id": "UBF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P17480",
                "type": "external"
            }
        ],
        "mass": 89406.0,
        "length": 764,
        "protein_name": "Nucleolar transcription factor 1",
        "gene_name": "UBTF",
        "organism": "Human",
        "refseq_name": "nucleolar transcription factor 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001070151",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070151",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBTF; UBF1; UBF",
        "gene_names_refseq": "CONDBA; NOR-90; UBF-1; UBF1; UBF2; UBF; UBTF",
        "protein_names_uniprotkb": "Nucleolar transcription factor 1; Autoantigen NOR-90; UBF-1; Upstream-binding factor 1",
        "protein_names_refseq": "90-kDa nucleolus organizer region autoantigen; autoantigen NOR-90; nucleolar transcription factor 1 isoform b; nucleolar transcription factor 1; upstream binding transcription factor, RNA polymerase I",
        "tax_id": 9606,
        "disease": "childhood-onset neurodegeneration with brain atrophy (Disease Ontology:DOID:0070474)",
        "pathway": " (hsa:7343);  (R-HSA-427413);  (R-HSA-73728);  (R-HSA-73762);  (R-HSA-73772);  (R-HSA-73863)",
        "pathway_count": 6,
        "publication_count": 133,
        "publication_id_list": "10.1101/2023.09.13.557529;10082553;10202152;10471499;10913176;11237011;11250901;11250903;11283244;11698641;11741541;11969401;12393749;12590579;12646563;14610093;14969726;1547496;16858408;17182730;17287340;17318177;17355984;18077418;18452278;18669648;19007248;19103806;1940801;19413330;19651622;19691289;19838300;20068231;20075868;21406692;21872626;21930779;21993680;22805593;23186163;23229552;2330041;23301498;23481700;23972994;24397554;24714562;24715725;25576301;25916849;26089203;26154972;26375851;26811146;26992070;27397612;27418187;27418309;27729611;27846572;27862975;2805069;28510447;28649982;28777933;28832583;28834231;28904123;29237092;29242379;29351928;29437277;29493099;29508533;29557506;30315122;30379171;30429286;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33123756;33141586;33151228;33214551;33298915;33392160;33465208;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34211107;34229054;34932366;35051231;35318648;35580925;36271492;36284347;37085611;37217939;37236968;37603967;37938771;38665916;40596516;40914422;7491500;7597036;7801123;7982918;9582279",
        "class_list": "",
        "function": "FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells., [RefSeq, PubMed]; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]., [RefSeq]; UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome. Publication Status: Online-Only, [RefSeq, PubMed]; UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6R8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0097110 scaffold protein binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center",
        "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "P17480-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13402-1",
        "uniprot_id": [
            {
                "id": "MYO7A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13402",
                "type": "external"
            }
        ],
        "mass": 254390.0,
        "length": 2215,
        "protein_name": "Unconventional myosin-VIIa",
        "gene_name": "MYO7A",
        "organism": "Human",
        "refseq_name": "unconventional myosin-VIIa isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000251",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000251",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO7A; USH1B",
        "gene_names_refseq": "DFNA11; DFNB2; MYO7A; MYOVIIA; MYU7A; NSRD2; USH1B",
        "protein_names_uniprotkb": "Unconventional myosin-VIIa",
        "protein_names_refseq": "myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)); unconventional myosin-VIIa isoform 1; unconventional myosin-VIIa",
        "tax_id": 9606,
        "disease": "Usher syndrome (Disease Ontology:DOID:0050439); Usher syndrome type 1B (Disease Ontology:DOID:0070655); autosomal recessive nonsyndromic deafness 2 (Disease Ontology:DOID:0110477); autosomal dominant nonsyndromic deafness 11 (Disease Ontology:DOID:0110543); Usher syndrome type 1 (Disease Ontology:DOID:0110826); sensorineural hearing loss (Disease Ontology:DOID:10003); Leber congenital amaurosis (Disease Ontology:DOID:14791); auditory system disease (Disease Ontology:DOID:2742); congenital nystagmus (Disease Ontology:DOID:9649)",
        "pathway": " (hsa:4647);  (R-HSA-2453902);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 4,
        "publication_count": 106,
        "publication_id_list": "10.1101/2023.09.13.557529;10025409;10075733;10094549;10364543;10447383;10617778;10737800;10753906;10821263;10930322;11123914;11163272;11237011;11274389;11964381;12036956;12112664;12177057;12407145;15121790;15221449;15300860;15314061;15471866;15660226;15865448;16679490;17255476;19049981;1925597;19309693;19643958;20192770;21493626;21687988;21709241;21774515;21901789;22665496;23023331;2303470;23090970;23481700;23559863;24831256;25122759;2542268;25645385;25798947;26720455;27331610;28281779;28887846;28904123;29393594;29557506;29786170;30779550;31154438;3170584;31844290;31848261;32161166;32209652;32357974;32387766;32938616;32983136;33123756;33691108;33968037;35051231;35580925;36284347;37074911;37586294;37938771;37996878;5315589;6288450;6342691;6512705;6589631;6679757;7568224;7870171;7929238;8022818;8105993;8622919;8842737;8884265;8884267;8900236;9002678;9070921;9171832;9171833;9354784;9382091;9490294;9541407;9703434;9718356;9920938",
        "class_list": "",
        "function": "Dispersed DNA variants underlie hearing loss in South Florida's minority population. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of two major isoforms of MYO7A in the retina: Considerations for gene therapy of Usher syndrome type 1B., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 60,
        "reported_interactions": 0,
        "missing_score": 9696,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 9,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9A011;F8VUN5;P78427;Q13321;Q14785;Q92821;Q92822",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0016020 membrane",
        "go_biological_process": "GO:0042490 mechanoreceptor differentiation;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007601 visual perception;GO:0007040 lysosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "Q13402-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NWU1-1",
        "uniprot_id": [
            {
                "id": "OXSM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NWU1",
                "type": "external"
            }
        ],
        "mass": 48843.0,
        "length": 459,
        "protein_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial",
        "gene_name": "OXSM",
        "organism": "Human",
        "refseq_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001138863",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138863",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OXSM",
        "gene_names_refseq": "CEM1; FASN2D; KASI; KS; OXSM",
        "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; 2.3.1.41; Beta-ketoacyl-ACP synthase",
        "protein_names_refseq": "3-ketoacyl-acyl carrier protein synthase; 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor; 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; 3-oxoacyl-acyl-carrier-protein synthase; acyl-malonyl acyl carrier protein-condensing enzyme; beta-ketoacyl synthase; beta-ketoacyl-ACP synthase; type II mitochondrial beta-ketoacyl synthase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54995);  (R-HSA-9837999)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "11237011;11923310;12198491;14623864;15522782;15668256;15870080;16115876;16959974;17101804;17242430;17297443;17579211;17924679;19608861;19841671;20068231;20877624;22262461;22710082;23201127;23931759;24315374;24520911;25505266;26504172;26923599;27496948;27642048;28377575;28396416;29301859;29932645;30120231;31327635;31695197;31844290;32350084;32387766;32488085;32897882;32938616;33257573;34357683;34704252;34943861;35870450;36629048;37087461;38253038;40596516;7623837",
        "class_list": "",
        "function": "Characterization of the human mitochondrial beta-ketoacyl synthase, [RefSeq, PubMed]; Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). Erratum:[J Ovarian Res. 2023 May 11;16(1):91. doi: 10.1186/s13048-023-01184-4. PMID: 37170129] Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1",
                "type": "external"
            },
            {
                "id": "7.1.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "1.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3",
                "type": "external"
            },
            {
                "id": "1.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3",
                "type": "external"
            },
            {
                "id": "6.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3",
                "type": "external"
            },
            {
                "id": "7.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2",
                "type": "external"
            },
            {
                "id": "4.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2",
                "type": "external"
            },
            {
                "id": "1.2.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1",
                "type": "external"
            },
            {
                "id": "1.8.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4",
                "type": "external"
            },
            {
                "id": "5.6.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7",
                "type": "external"
            },
            {
                "id": "2.3.1.168",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37",
                "type": "external"
            },
            {
                "id": "4.98.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1",
                "type": "external"
            },
            {
                "id": "1.1.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "1.2.1.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36",
                "type": "external"
            },
            {
                "id": "1.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-",
                "type": "external"
            },
            {
                "id": "1.2.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.1.1.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37",
                "type": "external"
            },
            {
                "id": "5.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8",
                "type": "external"
            },
            {
                "id": "1.3.8.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1",
                "type": "external"
            },
            {
                "id": "1.3.8.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.1.1.100",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100",
                "type": "external"
            },
            {
                "id": "1.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
                "type": "external"
            },
            {
                "id": "2.3.1.85",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            },
            {
                "id": "4.2.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "1.1.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41",
                "type": "external"
            },
            {
                "id": "2.3.3.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10",
                "type": "external"
            },
            {
                "id": "2.8.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.2.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2",
                "type": "external"
            },
            {
                "id": "1.1.1.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.7.11.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "3.4.21.92",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92",
                "type": "external"
            },
            {
                "id": "1.1.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35",
                "type": "external"
            },
            {
                "id": "2.7.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "1.1.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62",
                "type": "external"
            },
            {
                "id": "1.1.1.239",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239",
                "type": "external"
            },
            {
                "id": "1.1.1.178",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178",
                "type": "external"
            },
            {
                "id": "1.1.1.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53",
                "type": "external"
            },
            {
                "id": "1.1.1.159",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159",
                "type": "external"
            },
            {
                "id": "4.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3",
                "type": "external"
            },
            {
                "id": "6.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0051792 medium-chain fatty acid biosynthetic process;GO:0051790 short-chain fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q9NWU1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15070-1",
        "uniprot_id": [
            {
                "id": "OXA1L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15070",
                "type": "external"
            }
        ],
        "mass": 48520.0,
        "length": 435,
        "protein_name": "Mitochondrial inner membrane protein OXA1L",
        "gene_name": "OXA1L",
        "organism": "Human",
        "refseq_name": "mitochondrial inner membrane protein OXA1L",
        "refseq_ac": [
            {
                "id": "NP_005006",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005006",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OXA1L",
        "gene_names_refseq": "OXA1L1; OXA1L; OXA1",
        "protein_names_uniprotkb": "Mitochondrial inner membrane protein OXA1L; OXA1-like protein; OXA1Hs; Oxidase assembly 1-like protein",
        "protein_names_refseq": "OXA1-like protein; OXA1L mitochondrial inner membrane protein; epididymis secretory sperm binding protein; mitochondrial inner membrane protein OXA1L; oxidase (cytochrome c) assembly 1-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5018);  (R-HSA-5368286);  (R-HSA-5389840);  (R-HSA-5419276);  (R-HSA-6799198);  (R-HSA-9937383)",
        "pathway_count": 6,
        "publication_count": 69,
        "publication_id_list": "11220739;11237011;15358359;17803939;17936786;18429816;18782833;19349278;19524667;19716793;19752196;20186120;20406883;20552642;20601428;20739282;20858599;21907147;21924235;22172991;2250005;23186163;23553477;24191001;25233460;25418920;25576301;25678554;25892735;26375851;26992070;27029019;27499296;27626371;28063628;28228285;28514659;28832583;28892042;29242379;29393594;29508533;29632046;29769354;29786170;30201738;30315122;30779550;31530632;31666358;31866046;31998317;32265295;32320651;33243891;33602856;33878294;33879611;33882309;35333655;35614220;36302763;36596788;37141370;38199007;38665916;7991568;9247084;9571201",
        "class_list": "",
        "function": "Mechanism of membrane-tethered mitochondrial protein synthesis., [RefSeq, PubMed]; Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane (PubMed:17936786, PubMed:33602856, PubMed:7991568). Essential for the activity and assembly of cytochrome oxidase (PubMed:17936786, PubMed:7991568). Required for the correct biogenesis of ATP synthase and complex I in mitochondria (PubMed:17936786, PubMed:7991568)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]., [RefSeq]; Topogenesis of Oxa1 is a cooperative event of all five transmembrane segments (TM), and hexapeptide GLPWWG followed immediately by TM1 is essential for correct Oxa1 topogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087X0L7;B4DPA2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0097177 mitochondrial ribosome binding;GO:0032977 membrane insertase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0051262 protein tetramerization;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032780 negative regulation of ATP-dependent activity;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0051354 negative regulation of oxidoreductase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q15070-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P25189-1",
        "uniprot_id": [
            {
                "id": "MYP0_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P25189",
                "type": "external"
            }
        ],
        "mass": 27555.0,
        "length": 248,
        "protein_name": "Myelin protein P0",
        "gene_name": "MPZ",
        "organism": "Human",
        "refseq_name": "myelin protein P0 isoform MPZ precursor",
        "refseq_ac": [
            {
                "id": "NP_000521",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000521",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MPZ",
        "gene_names_refseq": "CMT1B; CMT1; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; P0",
        "protein_names_uniprotkb": "Myelin protein P0; MPP; Myelin peripheral protein; Myelin protein zero",
        "protein_names_refseq": "Charcot-Marie-Tooth neuropathy 1B; myelin peripheral protein; myelin protein P0 isoform MPZ precursor; myelin protein P0",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); congenital hypomyelinating neuropathy 2 (Disease Ontology:DOID:0070679); PCWH syndrome (Disease Ontology:DOID:0090111); Charcot-Marie-Tooth disease type 1B (Disease Ontology:DOID:0110152); Charcot-Marie-Tooth disease type 2J (Disease Ontology:DOID:0110157); Charcot-Marie-Tooth disease type 2I (Disease Ontology:DOID:0110158); Charcot-Marie-Tooth disease dominant intermediate D (Disease Ontology:DOID:0110200); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); sciatic neuropathy (Disease Ontology:DOID:11446); Adie syndrome (Disease Ontology:DOID:11549); neuropathy (Disease Ontology:DOID:870); diabetic neuropathy (Disease Ontology:DOID:9743); Roussy-Levy syndrome (MONDO:MONDO:0008392)",
        "pathway": " (hsa:4359);  (R-HSA-9619665)",
        "pathway_count": 2,
        "publication_count": 170,
        "publication_id_list": "10071056;10093067;10203854;10214757;10220111;10319895;10329755;10400691;10406984;10545037;10553995;10727776;10737979;10757804;10764043;10856243;10923043;10965800;11080237;11115854;11133365;11157804;11237011;11356866;11394999;11430795;11430802;11437164;11438991;11445635;11596785;11734543;11782409;11801400;11835375;12056842;12145339;12198163;12207932;12221176;12402337;12477701;12497641;12707985;12782656;12799134;12845552;14512514;14522948;14638973;14664827;14711881;14871447;15036333;15150276;15159512;15184631;15189448;15241803;15326256;15356632;15610069;15695336;15836632;15907797;16136673;16311519;16319321;16373334;16414078;16488608;16775239;16923174;1704008;17142269;1719967;17325040;17699610;17959798;18337304;18634568;18803322;19143832;19156870;19321787;19745155;1975954;19922439;20149798;20213556;20625412;20832498;21044070;21326363;21411665;21423190;21423191;21613327;21653862;21971831;22053691;22180461;22333914;22457349;22492709;22764250;22814607;23695165;23747866;23874858;24191038;24227709;24646194;24675079;25974668;26423937;26441514;27220739;27288457;27859941;28852375;29557506;29741879;29748249;31844290;35051231;7504284;7505151;7506095;7509228;7518101;7527371;7530774;7550231;7688964;7693129;7693130;7694726;7762451;7925941;7935840;8138712;8349731;8619637;8627307;8630052;8644725;8647822;8662541;8664899;8797476;8816708;8835320;8842374;8844219;8990016;9187667;9217235;9222756;9418958;9452055;9452091;9452099;9482253;9595994;9633821;9705348;9748295;9858769;9888385",
        "class_list": "",
        "function": "Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough., [RefSeq, PubMed]; Peripheral neuropathies caused by mutations in the myelin protein zero. Review article, [RefSeq, PubMed]; The cytoplasmic apposition (major dense line) in compact myelin may be stabilized via the hydrogen-bonding of beta-strands formed as a result of local P0-P0 aggregation., [RefSeq, PubMed]; This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 8621,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 13,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16072;Q5VTH4;Q92677;Q9BR67",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045202 synapse",
        "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0042552 myelination;GO:0098609 cell-cell adhesion;GO:0098743 cell aggregation",
        "synthesized_glycan_count": 0,
        "hit_score": 18.7,
        "record_id": "P25189-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30559-1",
        "uniprot_id": [
            {
                "id": "OXYR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30559",
                "type": "external"
            }
        ],
        "mass": 42772.0,
        "length": 389,
        "protein_name": "Oxytocin receptor",
        "gene_name": "OXTR",
        "organism": "Human",
        "refseq_name": "oxytocin receptor",
        "refseq_ac": [
            {
                "id": "NP_000907",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000907",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OXTR",
        "gene_names_refseq": "OT-R; OTR; OXTR",
        "protein_names_uniprotkb": "Oxytocin receptor; OT-R",
        "protein_names_refseq": "oxytocin receptor",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); impulse control disorder (Disease Ontology:DOID:10937); personality disorder (Disease Ontology:DOID:1510); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); substance abuse (Disease Ontology:DOID:302)",
        "pathway": " (hsa:5021);  (R-HSA-388479);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 90,
        "publication_id_list": "10.1101/2023.09.13.557529;10191087;10567430;10727532;10861009;11015615;11237011;11279203;11742120;11753430;11923477;12120503;12446593;1313946;14976224;15327388;15951850;16179383;16182515;16268778;16333859;16339447;16672911;16754659;16923326;17105757;17699341;18434541;18508290;18515384;18577758;18936096;1905813;19423652;19934046;20463780;20647384;20973922;2115785;21896752;22069312;22123970;24367110;24714562;24766294;25576301;27846572;2841328;28904123;29557506;2991279;30303493;30429286;3086311;30962532;31217245;31844290;32350084;32832646;32938616;33981976;35051231;35104164;35241813;35494241;35580925;35851571;36010968;38689124;38862858;39002451;39060750;39456718;4061066;4065330;6278592;6401806;7798245;7802081;7929452;7937899;8106369;8664309;9264324;9305846;9433921;9459574;9651149;9770463;9884074",
        "class_list": "",
        "function": "A Common OXTR Risk Variant Alters Regulation of Gene Expression by DNA Hydroxymethylation in Pregnant Human Myometrium., [RefSeq, PubMed]; Exploring the role of OXTR gene methylation in attachment development: A longitudinal study., [RefSeq, PubMed]; G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:11923477, PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:11923477, PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (PubMed:22069312, PubMed:35241813, PubMed:35851571). Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:19934046, PubMed:20647384, PubMed:21896752, PubMed:22123970, PubMed:24367110). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (PubMed:6278592). OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Grandmotherhood is associated with reduced OXTR DNA methylation., [RefSeq, PubMed]; Maternal Body Mass Index, Myometrium Contractility and Uterotonic Receptor Expression in Pregnancy., [RefSeq, PubMed]; Oxytocin/Oxytocin Receptor Signalling in the Gastrointestinal System: Mechanisms and Therapeutic Potential. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 9462,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15071",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004990 oxytocin receptor activity;GO:0005000 vasopressin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007565 female pregnancy;GO:0032870 cellular response to hormone stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "P30559-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000100010001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55157-1",
        "uniprot_id": [
            {
                "id": "MTP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55157",
                "type": "external"
            }
        ],
        "mass": 99351.0,
        "length": 894,
        "protein_name": "Microsomal triglyceride transfer protein large subunit",
        "gene_name": "MTTP",
        "organism": "Human",
        "refseq_name": "microsomal triglyceride transfer protein large subunit isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_000244",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000244",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTTP; MTP",
        "gene_names_refseq": "ABL; MTP; MTTP",
        "protein_names_uniprotkb": "Microsomal triglyceride transfer protein large subunit",
        "protein_names_refseq": "microsomal triglyceride transfer protein (large polypeptide, 88kDa); microsomal triglyceride transfer protein large subunit isoform 1 precursor; microsomal triglyceride transfer protein large subunit",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); familial hypercholesterolemia (Disease Ontology:DOID:13810); abetalipoproteinemia (Disease Ontology:DOID:1386); hyperinsulinism (Disease Ontology:DOID:2018); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4547);  (R-HSA-8866423);  (R-HSA-8963888);  (R-HSA-8964041)",
        "pathway_count": 4,
        "publication_count": 56,
        "publication_id_list": "10679949;10946006;11237011;11353333;11369260;11792722;12518019;12692552;12700345;14732096;14732481;15897609;16478722;17215532;17237796;17339654;1848237;19008531;19413330;21776394;22236406;22363685;22517366;23475612;23481700;25108285;26224785;27206948;27862975;2833496;29393594;29557506;30397120;31092671;31154438;31844290;34357683;36228741;36284347;37726765;38290649;38325741;4345202;6619141;7545943;7664034;7803401;7961826;8111381;8361539;8533758;8626595;8876250;8939939;9548923;9880564",
        "class_list": "",
        "function": "Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review and meta-analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Bulky hydrophobic side chains in the beta1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids., [RefSeq, PubMed]; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:16478722, PubMed:23475612, PubMed:26224785, PubMed:8876250, PubMed:8939939). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis., [RefSeq, PubMed]; MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]., [RefSeq]; Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K428;Q08AM4;Q6P5T3",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0034185 apolipoprotein binding;GO:0046982 protein heterodimerization activity;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0042157 lipoprotein metabolic process;GO:0051592 response to calcium ion;GO:0015914 phospholipid transport;GO:0034379 very-low-density lipoprotein particle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "P55157-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UQ26-6",
        "uniprot_id": [
            {
                "id": "RIMS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UQ26",
                "type": "external"
            }
        ],
        "mass": 160403.0,
        "length": 1411,
        "protein_name": "Regulating synaptic membrane exocytosis protein 2",
        "gene_name": "RIMS2",
        "organism": "Human",
        "refseq_name": "regulating synaptic membrane exocytosis protein 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001093587",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093587",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RIMS2; KIAA0751; RAB3IP3; RIM2",
        "gene_names_refseq": "CRSDS; OBOE; RAB3IP3; RIM2; RIMS2",
        "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 2; RIM 2; Rab-3-interacting molecule 2; Rab-3-interacting protein 3",
        "protein_names_refseq": "RAB3 interacting protein 3; Rab3-interacting protein; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; rab-3-interacting molecule 2; rab-3-interacting protein 3; rab3-interacting molecule 2; regulating synaptic membrane exocytosis protein 2 isoform a; regulating synaptic membrane exocytosis protein 2",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419); cone-rod synaptic disorder syndrome, congenital nonprogressive (MONDO:MONDO:0033543)",
        "pathway": " (hsa:9699)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10.1101/2023.09.13.557529;12620390;19690332;21406692;23999003;26375851;28377503;28657654;30779550;32157095;32470375;33392160;33912179;34087483;35051231;35580925;37217939",
        "class_list": "",
        "function": "Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47., [RefSeq, PubMed]; Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement. Erratum:[Am J Hum Genet. 2020 Sep 3;107(3):580. doi: 10.1016/j.ajhg.2020.08.004. PMID: 32888510], [RefSeq, PubMed]; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003)., [UniProtKB, PubMed]; The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KX91;F8WD47;O43413;Q86XL9;Q8IWV9;Q8IWW1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0098831 presynaptic active zone cytoplasmic component;GO:0070062 extracellular exosome;GO:0048786 presynaptic active zone;GO:0042734 presynaptic membrane",
        "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0006886 intracellular protein transport;GO:0030154 cell differentiation;GO:0042391 regulation of membrane potential;GO:2000463 positive regulation of excitatory postsynaptic potential",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9UQ26-6",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A087WUL8-1",
        "uniprot_id": [
            {
                "id": "NBPFJ_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A087WUL8",
                "type": "external"
            }
        ],
        "mass": 440408.0,
        "length": 3843,
        "protein_name": "NBPF family member NBPF19",
        "gene_name": "NBPF19",
        "organism": "Human",
        "refseq_name": "NBPF family member NBPF19",
        "refseq_ac": [
            {
                "id": "NP_001338294",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338294",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NBPF19",
        "gene_names_refseq": "NBPF19",
        "protein_names_uniprotkb": "NBPF family member NBPF19; Neuroblastoma breakpoint family member 19",
        "protein_names_refseq": "NBPF family member NBPF19; neuroblastoma breakpoint family member 19",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:101060226)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "26992070;28228285;28514659;28832583;28834231;29242379;29786170;30315122;31844290;32350084;32357974;32387766;32488085",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "A0A087WUL8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.001000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15661-1",
        "uniprot_id": [
            {
                "id": "TRYB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15661",
                "type": "external"
            }
        ],
        "mass": 30515.0,
        "length": 275,
        "protein_name": "Tryptase alpha/beta-1",
        "gene_name": "TPSAB1",
        "organism": "Human",
        "refseq_name": "tryptase alpha/beta-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_003285",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003285",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TPSAB1; TPS1; TPS2; TPSB1",
        "gene_names_refseq": "TPS1; TPS2; TPSAB1; TPSB1; TPSB2; Tryptase-2",
        "protein_names_uniprotkb": "Tryptase alpha/beta-1; 3.4.21.59; Tryptase I; Tryptase alpha-1; Tryptase-1",
        "protein_names_refseq": "Tryptase II; Tryptase beta-2; epididymis secretory sperm binding protein; mast cell alpha II tryptase; mast cell beta I tryptase; mast cell tryptase; tryptase alpha II; tryptase alpha-1; tryptase alpha/beta-1 precursor; tryptase beta I; tryptase beta-1; tryptase-1; tryptase-III",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7177);  (R-HSA-1592389)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "10898108;11237011;11830519;12162961;1311314;1371271;1390635;14670919;1480033;1783204;18039527;18854315;19159218;19748655;2159879;2169257;2176865;2187193;2269296;2383557;2546891;2551898;2557753;2677049;27749843;29557506;29741879;3058116;31337736;31611695;32157095;32709152;32717252;32777817;35051231;3543004;35580925;37818990;4216367;6263256;7669817;7746327;7780967;7826345;7890645;7896811;7981201;8015608;8194591;8314771;8530478;8576151;8621565;8645182;8663255;8804434;9261109;9346290;9422744;9578462;9632662;9920877",
        "class_list": "",
        "function": "Allosteric effects of alpha-tryptase protomers on neighboring beta-tryptase protomers likely result in the novel substrate repertoire of alpha/beta-tryptase tetramers that in turn cause some of the clinical features of hereditary alpha-tryptasemia and of other disorders involving mast cells., [RefSeq, PubMed]; Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals., [RefSeq, PubMed]; Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis., [RefSeq, PubMed]; Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1., [RefSeq, PubMed]; Mast Cell beta-Tryptase Is Enzymatically Stabilized by DNA. Publication Status: Online-Only, [RefSeq, PubMed]; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315)., [UniProtKB, UniProtKB, PubMed]; Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 8686,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D2E6R9;D2E6S1;P15157;Q15663;Q6B052;Q9H2Y4;Q9H2Y5;Q9UQI1",
        "ec_number_list": [
            {
                "id": "3.4.21.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34",
                "type": "external"
            },
            {
                "id": "3.4.24.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.21.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20",
                "type": "external"
            },
            {
                "id": "3.4.21.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39",
                "type": "external"
            },
            {
                "id": "3.4.21.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis;GO:0006952 defense response;GO:0022617 extracellular matrix disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q15661-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P3W6-1",
        "uniprot_id": [
            {
                "id": "NBPFA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P3W6",
                "type": "external"
            }
        ],
        "mass": 435634.0,
        "length": 3795,
        "protein_name": "NBPF family member NBPF10",
        "gene_name": "NBPF10",
        "organism": "Human",
        "refseq_name": "NBPF family member NBPF10 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001289300",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289300",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NBPF10",
        "gene_names_refseq": "AB6; AG1; NBPF10",
        "protein_names_uniprotkb": "NBPF family member NBPF10; Neuroblastoma breakpoint family member 10",
        "protein_names_refseq": "NBPF family member NBPF10 isoform a; NBPF family member NBPF10; neuroblastoma breakpoint family member 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100132406)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;25576301",
        "class_list": "",
        "function": "This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A075B762;Q5RHC0;Q9NWN6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q6P3W6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.001000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60721-1",
        "uniprot_id": [
            {
                "id": "NCKX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60721",
                "type": "external"
            }
        ],
        "mass": 121374.0,
        "length": 1099,
        "protein_name": "Sodium/potassium/calcium exchanger 1",
        "gene_name": "SLC24A1",
        "organism": "Human",
        "refseq_name": "sodium/potassium/calcium exchanger 1 isoform 5",
        "refseq_ac": [
            {
                "id": "NP_001287962",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287962",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC24A1; KIAA0702; NCKX1",
        "gene_names_refseq": "CSNB1D; HsT17412; NCKX1; NCKX; RODX; SLC24A1",
        "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1",
        "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 1; Na/Ca-K exchanger 1; retinal rod Na+/Ca+/K+ exchanger; sodium/potassium/calcium exchanger 1 isoform 5; solute carrier family 24 (sodium/potassium/calcium exchanger), member 1",
        "tax_id": 9606,
        "disease": "congenital stationary night blindness 1D (Disease Ontology:DOID:0110868)",
        "pathway": " (hsa:9187);  (R-HSA-2485179);  (R-HSA-425561);  (R-HSA-5619077)",
        "pathway_count": 4,
        "publication_count": 68,
        "publication_id_list": "10608890;10662833;11237011;11294880;12379639;12432397;12467591;12467592;1379636;14625281;15060069;1614872;16357253;16460277;1720239;1722240;18166528;19690332;20850105;2155175;2161380;23481700;2422346;2457685;2467600;24715725;2473195;25645385;2578616;26631410;26811146;26822852;2748346;27624628;2835761;2837463;28649982;29242379;29557506;3095147;31092671;31154438;31530632;31611695;3164688;31848261;32350084;32938616;33141586;33392160;33912179;35051231;35251023;35494241;3933561;4359491;4361997;4366891;6264430;6930647;7682292;8382952;8500562;8673138;8812493;8913594;9478004;9856482",
        "class_list": "",
        "function": "A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness., [RefSeq, PubMed]; Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:26631410). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105). Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105)., [UniProtKB, PubMed, PubMed]; Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation., [UniProtKB, UniProtKB, UniProtKB]; The index patient and his affected brother carry a homozygous single-nucleotide variants (SNVs) in sodium-calcium, potassium exchanger (SLC24A1) (c.2401G > T)., [RefSeq, PubMed]; This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]; We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43485;O75184;Q17RM9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0019867 outer membrane",
        "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0007601 visual perception;GO:0035725 sodium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "O60721-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P51449-1",
        "uniprot_id": [
            {
                "id": "RORG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P51449",
                "type": "external"
            }
        ],
        "mass": 58195.0,
        "length": 518,
        "protein_name": "Nuclear receptor ROR-gamma",
        "gene_name": "RORC",
        "organism": "Human",
        "refseq_name": "nuclear receptor ROR-gamma isoform b",
        "refseq_ac": [
            {
                "id": "NP_001001523",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001523",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RORC; NR1F3; RORG; RZRG",
        "gene_names_refseq": "IMD42; NR1F3; RORC; RORG; RZR-GAMMA; RZRG; TOR",
        "protein_names_uniprotkb": "Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma",
        "protein_names_refseq": "nuclear receptor ROR-gamma isoform b; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma",
        "tax_id": 9606,
        "disease": "immunodeficiency 42 (Disease Ontology:DOID:0111940); Sjogren's syndrome (Disease Ontology:DOID:12894); tuberculosis (Disease Ontology:DOID:399)",
        "pathway": " (hsa:6097);  (R-HSA-383280);  (R-HSA-6785807);  (R-HSA-9931509);  (R-HSA-9931510);  (R-HSA-9933387)",
        "pathway_count": 6,
        "publication_count": 132,
        "publication_id_list": "10023775;10198158;10219247;10235266;10369418;10510379;10542397;10586089;10857746;10867011;11058569;11084045;11104795;11120780;11237011;11278437;11278729;11356008;11404481;11463377;11865025;11960372;12223527;12242343;12377782;12600988;12832402;14634100;14712222;14750904;15116091;15175151;15261459;15584925;15805299;15869882;15896744;15950906;16007214;16048438;16107692;16205632;16236134;16397018;16451196;16510571;16540365;16606674;16751179;17427945;17458857;17572495;17994337;18243101;18317514;18353781;18368049;18447642;18644974;19124156;19185846;19381306;19397496;1971514;19965867;20203100;20211758;20493732;21102457;21252155;21499262;21628546;21689689;21730069;21853531;21937440;21994466;22046235;22170608;22205702;22383755;22693070;22789990;22851691;23086340;23124025;23172665;23455323;23555662;23967200;24097101;24196956;24743777;25234944;26160376;29493099;29557506;34252205;34547329;34673799;34819367;35051231;35494241;35580925;38722677;7510216;7512451;7529288;7795521;7796300;7811290;7898939;7907877;8060328;8085155;8156598;8402897;8602263;8621622;8622974;8663118;8668165;8797861;8816495;9013879;9062340;9651359;9653119;9723655;9736340;9822675;9874564",
        "class_list": "",
        "function": "Conformational Changes of RORgamma During Response Element Recognition and Coregulator Engagement., [RefSeq, PubMed]; Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORgammat. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear receptor essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (PubMed:21499262). Required for the generation of LTi (lymphoid tissue inducer) cells (By similarity). Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2 (By similarity). Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program (PubMed:21499262). Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus (PubMed:21499262). Plays a key role in tolerance to gut microbiota and foreign antigens in food by mediating differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms and food proteins (By similarity). Specifically expressed in antigen-presenting cell populations, such as (1) type 3 innate lymphoid cells (ILC3s), which are required for tolerance to gut microbiota, (2) Thetis cells, also named Janus cells, which are enriched in gut lymph nodes during early life and are required for oral tolerance, and (3) a subset of dendritic cells (By similarity). Following activation by an unknown ligand in antigen-presenting cells, promotes recruitment of transcription regulators, such as PRDM16 or ZBTB46, and drives differentiation of pTreg cells, which maintain immune tolerance and prevent autoimmune diseases (By similarity). May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus (By similarity)., [UniProtKB, UniProtKB, PubMed]; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; RORC gene polymorphism is associated with acute kidney injury following cardiac surgery., [RefSeq, PubMed]; Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth., [RefSeq, PubMed]; The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SZR9;Q8N5V7;Q8NCY8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008142 oxysterol binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060612 adipose tissue development;GO:0010906 regulation of glucose metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "P51449-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHP3-2",
        "uniprot_id": [
            {
                "id": "UBP25_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHP3",
                "type": "external"
            }
        ],
        "mass": 122218.0,
        "length": 1055,
        "protein_name": "Ubiquitin carboxyl-terminal hydrolase 25",
        "gene_name": "USP25",
        "organism": "Human",
        "refseq_name": "ubiquitin carboxyl-terminal hydrolase 25 isoform USP25m",
        "refseq_ac": [
            {
                "id": "NP_001269970",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269970",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "USP25; USP21",
        "gene_names_refseq": "EIG19; USP21; USP25",
        "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 25; 3.4.19.12; Deubiquitinating enzyme 25; USP on chromosome 21; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25",
        "protein_names_refseq": "USP on chromosome 21; deubiquitinating enzyme 25; ubiquitin carboxyl-terminal hydrolase 25 isoform USP25m; ubiquitin carboxyl-terminal hydrolase 25; ubiquitin thioesterase 25; ubiquitin thiolesterase 25; ubiquitin-specific processing protease 25",
        "tax_id": 9606,
        "disease": "epilepsy, idiopathic generalized, susceptibility to, 19 (MONDO:MONDO:0976128)",
        "pathway": " (hsa:29761);  (R-HSA-5689880)",
        "pathway_count": 2,
        "publication_count": 125,
        "publication_id_list": "10444327;10612803;10644437;10982817;11566882;11597335;11923872;12917689;12917691;14661020;15053880;15916963;16214042;16501887;16901786;16964248;17290220;17443180;17873522;17924679;17980597;17981138;18172164;18467330;18538659;18632802;18636086;19015242;19135894;19188362;19363159;19398555;19424180;19440361;19838211;19874889;19909739;19910467;20096447;20228808;20368735;20501646;21239494;21362556;21571647;21596315;21659512;21849505;21962518;22029577;22085928;22128162;22216260;23042150;23159851;23186163;23395819;23481700;23486064;23824326;23825189;24056413;24260525;24493797;24715725;24896179;25197364;25305019;25576301;25578727;25645385;25755282;25880248;27600516;27846572;27862975;28619731;28832583;28834231;29242379;29393594;29493099;29508533;29518389;29557506;29786170;30315122;30429286;30478318;30484775;30579117;30926243;31154438;31217245;31844290;31848261;32157095;32161166;32350084;32502341;32897882;32938616;32983136;33123756;33141586;33592498;33691108;33717175;33912179;33968037;33981976;34171305;34509645;34932366;35051231;35580925;36010968;36215666;36241641;36284347;37339955;37683630;38521787;38875478;7578059",
        "class_list": "",
        "function": "Characterization of alternatively spliced products and tissue-specific isoforms, [RefSeq, PubMed]; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease. Publication Status: Online-Only, [RefSeq, PubMed]; Heterozygous variants in USP25 cause genetic generalized epilepsy. Erratum:[Brain. 2025 Oct 3;148(10):e95. doi: 10.1093/brain/awaf287. PMID: 40794894], [RefSeq, PubMed]; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function., [UniProtKB]; Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]., [RefSeq]; Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C0LSZ0;Q6DHZ9;Q9H9W1",
        "ec_number_list": [
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008233 peptidase activity;GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0036211 protein modification process;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination;GO:0031647 regulation of protein stability",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q9UHP3-2",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NBM8-1",
        "uniprot_id": [
            {
                "id": "PCYXL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NBM8",
                "type": "external"
            }
        ],
        "mass": 54646.0,
        "length": 494,
        "protein_name": "Prenylcysteine oxidase 1-like",
        "gene_name": "PCYOX1L",
        "organism": "Human",
        "refseq_name": "prenylcysteine oxidase 1-like isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001287983",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287983",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PCYOX1L; PSEC0105",
        "gene_names_refseq": "PCYOX1L",
        "protein_names_uniprotkb": "Prenylcysteine oxidase 1-like; 1.8.3.5",
        "protein_names_refseq": "prenylcysteine oxidase 1-like isoform 2; prenylcysteine oxidase-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:78991);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "11237011;1435334;14630798;15297306;15340161;16303743;20237496;23481700;23640497;26154972;26992070;28228285;28832583;28904123;29242379;29557506;29632046;29632711;29769354;30315122;30573663;31092671;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33936100;33968037;34087483;34211107;34509645;34932366;35051231;35154160;38665916;39322016;6457647;8467233",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Does not metabolize shorter prenyl chain compounds (Probable). Required in the mevalonate pathway to regulate prenylation and enhances the bactericidal activity of neutrophils (By similarity). Promotes the assembly of the postsynaptic ion channel ASIC1a (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z4S2;Q8NCY5;Q8NF69;Q9BTE8;Q9BWS3",
        "ec_number_list": [
            {
                "id": "1.8.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2",
                "type": "external"
            },
            {
                "id": "2.3.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "1.8.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5",
                "type": "external"
            },
            {
                "id": "1.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0001735 prenylcysteine oxidase activity;GO:0102149 farnesylcysteine lyase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0031093 platelet alpha granule lumen",
        "go_biological_process": "GO:0070944 neutrophil-mediated killing of bacterium;GO:0030328 prenylcysteine catabolic process;GO:0030327 prenylated protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q8NBM8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TDC0-1",
        "uniprot_id": [
            {
                "id": "MYOZ3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TDC0",
                "type": "external"
            }
        ],
        "mass": 27157.0,
        "length": 251,
        "protein_name": "Myozenin-3",
        "gene_name": "MYOZ3",
        "organism": "Human",
        "refseq_name": "myozenin-3",
        "refseq_ac": [
            {
                "id": "NP_001116325",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116325",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYOZ3; FRP3",
        "gene_names_refseq": "CS-3; CS3; FATZ-3; FRP3; MYOZ3",
        "protein_names_uniprotkb": "Myozenin-3; Calsarcin-3; FATZ-related protein 3",
        "protein_names_refseq": "FATZ-related protein 3; calsarcin-3; myozenin-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91977)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;11842093;19472918",
        "class_list": "",
        "function": "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins., [RefSeq, PubMed]; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9Q4;D3DQG9;Q8IVM1;Q8IVN1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0051373 FATZ binding;GO:0031433 telethonin binding",
        "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030018 Z disc",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8TDC0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99487-1",
        "uniprot_id": [
            {
                "id": "PAFA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99487",
                "type": "external"
            }
        ],
        "mass": 44036.0,
        "length": 392,
        "protein_name": "Platelet-activating factor acetylhydrolase 2, cytoplasmic",
        "gene_name": "PAFAH2",
        "organism": "Human",
        "refseq_name": "platelet-activating factor acetylhydrolase 2, cytoplasmic isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000428",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000428",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAFAH2",
        "gene_names_refseq": "HSD-PLA2; PAFAH2",
        "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase 2, cytoplasmic; 2.3.1.149; 3.1.1.47; PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; Platelet-activating factor acetyltransferase PAFAH2; SD-PLA2; Serine-dependent phospholipase A2; hSD-PLA2",
        "protein_names_refseq": "PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; SD-PLA2; platelet-activating factor acetylhydrolase 2, 40kDa; platelet-activating factor acetylhydrolase 2, cytoplasmic isoform 1; platelet-activating factor acetylhydrolase 2, cytoplasmic; platelet-activating factor acetyltransferase PAFAH2; serine-dependent phospholipase A2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5051);  (R-HSA-418346)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10228183;11237011;11294621;12406338;12907444;16650870;17157859;17272759;21882811;23481700;25576301;25707358;25892735;26154972;26791393;27600516;27846572;27920218;28832583;28834231;29242379;29557506;29632046;29769354;30429286;31324691;31530632;31844290;32357974;32938616;33298915;33592498;33968037;34087483;34171305;35580925;8955149;9218411;9494101",
        "class_list": "",
        "function": "Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data show that the activity of plasma platelet activating factor acetylhydrolase (PAF-AH) increases in parallel with diabetic retinopathy (DR) severity., [RefSeq, PubMed]; Examines substrate specificity for intracellular and plasma PAF-AHs, [RefSeq, PubMed]; Lp-PLA2 was higher in those with more extensive Coronary artery disease, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PAF-AH II exerts strong neuroprotective effects against ischemic injury: the neurological deficit scores, cerebral edema index, and relative infarction volume are all significantly lower in PAFAH2 transgenic mice than in wild-type mice., [RefSeq, PubMed]; Presence of platelet-activating factor acetylhydrolase II in a restricted pattern in human skin; it is involved in protecting this organ against oxidative stress through the degradation of oxidatively modified bioactive phospholipids., [RefSeq, PubMed]; The oligomeric state of PAFAH-II drives functional protein trafficking. PAFAH-II localization to the membrane is critical for substrate acquisition and effective oxidative stress protection., [RefSeq, PubMed]; This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPK1;O15458;Q5SY02",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "2.3.1.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "2.3.1.149",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0005543 phospholipid binding;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007596 blood coagulation;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q99487-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53FV1-1",
        "uniprot_id": [
            {
                "id": "ORML2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53FV1",
                "type": "external"
            }
        ],
        "mass": 17363.0,
        "length": 153,
        "protein_name": "ORM1-like protein 2",
        "gene_name": "ORMDL2",
        "organism": "Human",
        "refseq_name": "ORM1-like protein 2",
        "refseq_ac": [
            {
                "id": "NP_054901",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054901",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ORMDL2; HSPC160; MSTP095",
        "gene_names_refseq": "HSPC160; MST095; MSTP095; ORMDL2; adoplin-2",
        "protein_names_uniprotkb": "ORM1-like protein 2; Adoplin-2",
        "protein_names_refseq": "ORM1-like protein 2; expressed in normal aorta",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841)",
        "pathway": " (hsa:29095);  (R-HSA-1660661)",
        "pathway_count": 2,
        "publication_count": 128,
        "publication_id_list": "10722674;10751414;10802064;10947957;11237011;11937514;12093374;14685229;14685263;14976195;15063729;15328338;15337768;16100120;16118219;16571669;16793762;16895911;17023427;17050692;17331073;17355976;17449912;17591919;17928364;17982138;18165232;18165233;18184806;19005213;19233134;19416851;19506037;20061445;20110355;20182505;21620961;22424782;22517924;22970244;23066021;23180825;23481700;23602659;23754960;24569996;24715725;24782409;25395622;25576301;25645385;25788259;25802875;26154972;26375851;26992070;27600516;27846572;28228285;28514659;28575652;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29557506;29563527;29786170;30315122;30410026;30484775;30524438;30779550;31154438;31217245;31844290;31848261;31895563;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34932366;35051231;35318648;35409383;35580925;36010968;36215666;36241641;36284347;36902339;36907437;37224812;37390971;37938771;4339164;4817756;9029102;9188692;9312549;9363775",
        "class_list": "",
        "function": "Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells., [RefSeq, PubMed]; ORMDL1, ORMDL2 and ORMDL3 mediate the feedback response in ceramide biosynthesis., [RefSeq, PubMed]; Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA58;Q7Z4E5;Q8NFX0;Q9P004",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:1900060 negative regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis;GO:2000303 regulation of ceramide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q53FV1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13087-1",
        "uniprot_id": [
            {
                "id": "PDIA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13087",
                "type": "external"
            }
        ],
        "mass": 58206.0,
        "length": 525,
        "protein_name": "Protein disulfide-isomerase A2",
        "gene_name": "PDIA2",
        "organism": "Human",
        "refseq_name": "protein disulfide-isomerase A2 precursor",
        "refseq_ac": [
            {
                "id": "NP_006840",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006840",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDIA2; PDIP",
        "gene_names_refseq": "PDA2; PDIA2; PDIP; PDIR; PDI",
        "protein_names_uniprotkb": "Protein disulfide-isomerase A2; 5.3.4.1; PDIp; Pancreas-specific protein disulfide isomerase",
        "protein_names_refseq": "Rho GDP dissociation inhibitor gamma; pancreas-specific protein disulfide isomerase; pancreatic protein disulfide isomerase; protein disulfide isomerase, pancreatic; protein disulfide isomerase-associated 2; protein disulfide-isomerase A2 precursor; protein disulfide-isomerase A2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64714);  (R-HSA-9925561)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "11237011;11968009;12475965;19150607;19429457;23167757;24715725;26154972;28228285;29741879;31844290;32928873;35051231;37017923;37978154;38589675;8561901;9115635",
        "class_list": "",
        "function": "Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins., [UniProtKB, PubMed, PubMed]; Evidence that protein disulfide isomerase (PDI) is involved in DNA-nuclear matrix anchoring., [RefSeq, PubMed]; PDIA2 has a dual function in promoting androgen deprivation therapy induced venous thrombosis events and castrate resistant prostate cancer progression., [RefSeq, PubMed]; PDIp can also serve as an effective modulator of the cellular levels and biological actions of endogenous estrogens in the pancreas where estrogen receptors alpha and beta and PDIp are co-present., [RefSeq, PubMed]; Protein Disulfide Isomerase A2 Is Correlated with Immune Infiltrates and Is a Novel Prognostic Biomarker in Glioma Patients., [RefSeq, PubMed]; Structures and functions of human PDIp are redox-regulated through formation of an inter-subunit disulfide bond between two cysteine-4 residues, [RefSeq, PubMed]; The involvement of PDIA2 gene in the progression of renal cell carcinoma is potentially through regulation of JNK signaling pathway., [RefSeq, PubMed]; This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ZJ64;B4DI27;Q2WGM4;Q4TT67;Q6B010;Q96KJ6;Q9BW95",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.2.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.1",
                "type": "external"
            },
            {
                "id": "3.4.21.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.35",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.21.71",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.71",
                "type": "external"
            },
            {
                "id": "3.4.21.70",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.70",
                "type": "external"
            },
            {
                "id": "3.4.17.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1",
                "type": "external"
            },
            {
                "id": "3.4.17.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "3.4.17.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.15",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "2.1.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.20",
                "type": "external"
            },
            {
                "id": "3.4.21.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0005496 steroid binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress;GO:0006621 protein retention in ER lumen;GO:0034975 protein folding in endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q13087-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13796-1",
        "uniprot_id": [
            {
                "id": "SHRM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13796",
                "type": "external"
            }
        ],
        "mass": 176410.0,
        "length": 1616,
        "protein_name": "Protein Shroom2",
        "gene_name": "SHROOM2",
        "organism": "Human",
        "refseq_name": "protein Shroom2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001307592",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307592",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SHROOM2; APXL",
        "gene_names_refseq": "APXL; HSAPXL; SHROOM2",
        "protein_names_uniprotkb": "Protein Shroom2; Apical-like protein; Protein APXL",
        "protein_names_refseq": "APX homolog of Xenopus; apical-like protein; protein Shroom2 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:357)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;16615870;16959974;17081983;19664995;21406692;22634755;23719902;24275569;27600516;29423651;29557506;30160833;30418433;30429286;30683844;31092671;31154438;31844290;32157095;32350084;32938616;33298915;33981976;34171305;35051231;35494241;35580925;36284347;7795590",
        "class_list": "",
        "function": "May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity)., [UniProtKB]; SHROOM2 deletion is associated with Ocular albinism with infertility and late-onset sensorineural hearing loss., [RefSeq, PubMed]; SHROOM2 is downregulated in nasopharyngeal carcinoma and is implicated in the suppression of cancer cell invasion and metastasis by preventing EMT, which is largely independent of Rho-ROCK signaling. Publication Status: Online-Only, [RefSeq, PubMed]; These findings provide genetic and molecular insights into the effects of rare damaging variants in SHROOM2, indicating that such variants of SHROOM2 might contribute to the risk of human Neural tube defects, [RefSeq, PubMed]; This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]., [RefSeq]; We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)). Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIQ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0008013 beta-catenin binding;GO:0015280 ligand-gated sodium channel activity",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005923 bicellular tight junction",
        "go_biological_process": "GO:0008057 eye pigment granule organization;GO:0043482 cellular pigment accumulation;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q13796-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UIL4-1",
        "uniprot_id": [
            {
                "id": "KIF25_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UIL4",
                "type": "external"
            }
        ],
        "mass": 40686.0,
        "length": 384,
        "protein_name": "Kinesin-like protein KIF25",
        "gene_name": "KIF25",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF25 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_005346",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005346",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF25; KNSL3",
        "gene_names_refseq": "KIF25; KNSL3",
        "protein_names_uniprotkb": "Kinesin-like protein KIF25; Kinesin-like protein 3",
        "protein_names_refseq": "kinesin-like 3; kinesin-like protein 3; kinesin-like protein KIF25 isoform 2; kinesin-like protein KIF25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3834);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 3,
        "publication_count": 114,
        "publication_id_list": "10052452;10318838;10445031;10559959;10761932;10921873;11172815;11237011;11493604;11689559;11703931;11726511;11739780;11748249;11782313;12047556;12070132;12368902;1406973;14504276;14654841;15029241;15037235;15272311;15326200;15616190;15632110;15813748;16030262;1607388;16262723;1631136;16571679;16633337;1680566;16912714;16926190;16940185;17113389;17253781;17346968;17360540;17429068;17451557;17538014;17760859;17927562;17956946;18182008;18287528;18342609;18524849;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1957170;19631211;19758564;20005805;20136777;20357002;20427317;20462495;20534429;20637885;21219331;2142332;21550981;21689688;21844168;22013193;22094269;22304919;22354037;23396477;2521221;2522352;25364732;25436559;25492864;28263957;31217245;3130248;3134048;31530632;7528108;7539720;7822426;7844144;7929562;8001155;8128252;8132710;8221884;8253837;8505331;8548803;8599929;8602245;8620540;9114004;9177194;9244307;9288971;9405360;9751720;9925916;9990005",
        "class_list": "",
        "function": "Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037)., [UniProtKB, UniProtKB, PubMed, PubMed]; The activity of Kif25 during interphase is required to maintain a centred nucleus to ensure the spindle is stably oriented at the onset of mitosis. Erratum:[Nat Cell Biol. 2017 May 31;19(6):740. doi: 10.1038/ncb3546. PMID: 28561052], [RefSeq, PubMed]; The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0C3;O94775;Q5SZU9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0051289 protein homotetramerization;GO:0010507 negative regulation of autophagy;GO:0007018 microtubule-based movement;GO:0046603 negative regulation of mitotic centrosome separation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q9UIL4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKP3-1",
        "uniprot_id": [
            {
                "id": "ITBP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKP3",
                "type": "external"
            }
        ],
        "mass": 38382.0,
        "length": 347,
        "protein_name": "Integrin beta-1-binding protein 2",
        "gene_name": "ITGB1BP2",
        "organism": "Human",
        "refseq_name": "integrin beta-1-binding protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_036410",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036410",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ITGB1BP2; MSTP015",
        "gene_names_refseq": "CHORDC3; ITGB1BP2; ITGB1BP; MELUSIN; MSTP015",
        "protein_names_uniprotkb": "Integrin beta-1-binding protein 2; Melusin",
        "protein_names_refseq": "integrin beta 1 binding protein (melusin) 2; integrin beta-1-binding protein 2 isoform 1; integrin beta-1-binding protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26548)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "10506186;12496958;30484775;33392160;33592498;36215666",
        "class_list": "",
        "function": "May play a role during maturation and/or organization of muscles cells., [UniProtKB]; Studies in mouse show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress., [RefSeq, PubMed]; This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32N04;Q549J7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0030018 Z disc",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007517 muscle organ development;GO:0051298 centrosome duplication",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q9UKP3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6J6-1",
        "uniprot_id": [
            {
                "id": "KCNE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6J6",
                "type": "external"
            }
        ],
        "mass": 14472.0,
        "length": 123,
        "protein_name": "Potassium voltage-gated channel subfamily E member 2",
        "gene_name": "KCNE2",
        "organism": "Human",
        "refseq_name": "potassium voltage-gated channel subfamily E member 2",
        "refseq_ac": [
            {
                "id": "NP_751951",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_751951",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KCNE2",
        "gene_names_refseq": "ATFB4; KCNE2; LQT5; LQT6; MIRP1",
        "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 2; MiRP1; MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1",
        "protein_names_refseq": "cardiac voltage-gated potassium channel accessory subunit 2; minK-related peptide-1; minimum potassium ion channel-related peptide 1; potassium channel subunit beta MiRP1; potassium channel subunit, MiRP1; potassium channel, voltage gated subfamily E regulatory beta subunit 2; potassium voltage-gated channel subfamily E member 2; potassium voltage-gated channel, Isk-related family, member 2; voltage-gated K+ channel subunit MIRP1",
        "tax_id": 9606,
        "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 6 (Disease Ontology:DOID:0110648); long QT syndrome (Disease Ontology:DOID:2843)",
        "pathway": " (hsa:9992);  (R-HSA-5576890);  (R-HSA-5576893)",
        "pathway_count": 3,
        "publication_count": 25,
        "publication_id_list": "10219239;10646604;11034315;11101505;11874988;12185453;15266014;15368194;16922724;16939434;16949586;18093912;19716085;20533308;22180649;24591645;24681347;25966690;27147833;31270966;31679457;33464998;39272981;7586312;9230439",
        "class_list": "",
        "function": "An arginine/lysine-based motif ([R/K](S)[R/K][R/K]) in the proximal C-terminus regulating the endoplasmic reticulum (ER) export of KCNE1 and KCNE2., [RefSeq, PubMed]; Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:10219239, PubMed:11034315, PubMed:11101505, PubMed:12185453, PubMed:20533308). KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:10219239, PubMed:11034315, PubMed:11101505, PubMed:12185453, PubMed:20533308). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:11101505, PubMed:20533308). Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:10219239, PubMed:12185453). May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (PubMed:11034315). May associate with HCN1 and HCN2 channel subunits to increase potassium current (By similarity). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; KCNE2 rs8134775 was associated with a decreased atrial fibrillation (AF) risk in the Chinese Han population in the allele model. Minor allele T of GJA5 rs35594137 was associated with a decreased AF risk, and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive models. Results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF in the Chinese Han population., [RefSeq, PubMed]; The Multifunctional Role of KCNE2: From Cardiac Arrhythmia to Multisystem Disorders. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The focal adhesion protein Testin modulates KCNE2 potassium channel beta subunit activity., [RefSeq, PubMed]; Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5H1P3;D3DSF8;Q52LJ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005764 lysosome;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex",
        "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0060306 regulation of membrane repolarization;GO:0071466 cellular response to xenobiotic stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9Y6J6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6M4-1",
        "uniprot_id": [
            {
                "id": "KC1G3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6M4",
                "type": "external"
            }
        ],
        "mass": 51389.0,
        "length": 447,
        "protein_name": "Casein kinase I isoform gamma-3",
        "gene_name": "CSNK1G3",
        "organism": "Human",
        "refseq_name": "casein kinase I isoform gamma-3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001026982",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026982",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CSNK1G3",
        "gene_names_refseq": "CKI-gamma 3; CSNK1G3L; CSNK1G3",
        "protein_names_uniprotkb": "Casein kinase I isoform gamma-3; 2.7.11.1; CKI-gamma 3",
        "protein_names_refseq": "casein kinase I isoform gamma-3 isoform 2",
        "tax_id": 9606,
        "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cholelithiasis (Disease Ontology:DOID:10211); prostate cancer (Disease Ontology:DOID:10283); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121)",
        "pathway": " (hsa:1456)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;17081983;18669648;18691976;22299025;25892735;26154972;27920218;28467828;28514659;29632711;31154438;31530632;31844290;31848261;32350084;33592498;33936100;33968037;34357683;35051231;35154160;35487243;36433954;39033888;9925945",
        "class_list": "",
        "function": "A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth., [RefSeq, PubMed]; CircCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1gamma3 in WNT signaling., [RefSeq, PubMed]; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)., [UniProtKB]; This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K040;B4DSH2;B7Z9Q4;E7EVD0;Q86WZ7;Q9Y6M3",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0036211 protein modification process;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q9Y6M4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86W25-1",
        "uniprot_id": [
            {
                "id": "NAL13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86W25",
                "type": "external"
            }
        ],
        "mass": 118884.0,
        "length": 1043,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 13",
        "gene_name": "NLRP13",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 13 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001307986",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307986",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP13; NALP13; NOD14",
        "gene_names_refseq": "CLR19.7; NALP13; NLRP13; NOD14; PAN13",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 13; Nucleotide-binding oligomerization domain protein 14",
        "protein_names_refseq": "NACHT, LRR and PYD containing protein 13; NACHT, LRR and PYD domains-containing protein 13 isoform 2; NACHT, LRR and PYD domains-containing protein 13; NACHT, leucine rich repeat and PYD containing 13; nucleotide-binding oligomerization domain protein 14; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126204)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;12563287;12766759;17924679;19074885;20403135;24714562;34087483;35051231;35494241;35580925",
        "class_list": "",
        "function": "Involved in inflammation., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7RTR5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q86W25-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A1B0GUC4-1",
        "uniprot_id": [
            {
                "id": "MYCOS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A1B0GUC4",
                "type": "external"
            }
        ],
        "mass": 8950.0,
        "length": 80,
        "protein_name": "Myocilin opposite strand protein",
        "gene_name": "MYOCOS",
        "organism": "Human",
        "refseq_name": "myocilin opposite strand protein",
        "refseq_ac": [
            {
                "id": "NP_001355093",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355093",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYOCOS",
        "gene_names_refseq": "MYOCOS",
        "protein_names_uniprotkb": "Myocilin opposite strand protein",
        "protein_names_refseq": "myocilin opposite strand protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:110806290)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A1B0GTE5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A1B0GUC4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MVU1-1",
        "uniprot_id": [
            {
                "id": "NCF1C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MVU1",
                "type": "external"
            }
        ],
        "mass": 41851.0,
        "length": 366,
        "protein_name": "Putative neutrophil cytosol factor 1C",
        "gene_name": "NCF1C",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NCF1C; SH3PXD1C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative neutrophil cytosol factor 1C; NCF-1C; Putative SH3 and PX domain-containing protein 1C",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "chronic granulomatous disease (Disease Ontology:DOID:3265); rheumatoid arthritis (Disease Ontology:DOID:7148)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 26,
        "publication_id_list": "22706990;23783831;27920218;28063628;28218747;28228285;28832583;28834231;28860189;28904123;29242379;29393594;29508533;29557506;29632046;29632711;29786170;30315122;31092671;31611695;31844290;31848261;31998317;32983136;33091337;34357683",
        "class_list": "",
        "function": "May be required for activation of the latent NADPH oxidase (necessary for superoxide production)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045730 respiratory burst;GO:0042554 superoxide anion generation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "A8MVU1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000110.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H3R2-1",
        "uniprot_id": [
            {
                "id": "MUC13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H3R2",
                "type": "external"
            }
        ],
        "mass": 54604.0,
        "length": 512,
        "protein_name": "Mucin-13",
        "gene_name": "MUC13",
        "organism": "Human",
        "refseq_name": "mucin-13 precursor",
        "refseq_ac": [
            {
                "id": "NP_149038",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149038",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC13; DRCC1; PRO20221; RECC",
        "gene_names_refseq": "DRCC1; MUC-13; MUC13",
        "protein_names_uniprotkb": "Mucin-13; Down-regulated in colon cancer 1; MUC-13",
        "protein_names_refseq": "down-regulated in colon cancer 1; mucin 13, epithelial transmembrane; mucin-13 precursor; mucin-13",
        "tax_id": 9606,
        "disease": "ischemia (Disease Ontology:DOID:326)",
        "pathway": " (hsa:56667);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-9696264);  (R-HSA-9696270);  (R-HSA-9696273);  (R-HSA-977068)",
        "pathway_count": 10,
        "publication_count": 98,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10330415;10430883;10504389;10664463;10742600;10753916;11042166;11062056;11110698;11237011;11278439;11283017;11304796;11606584;11784792;11821425;11940653;12244061;12464682;12842009;12855678;12975309;1329093;14656219;14732713;15466199;15486459;15560372;15599692;15620693;15687324;15738000;15904467;16151858;16251947;16319059;16481321;17050534;17113861;18490740;18537974;18776906;18818202;18834073;18996843;19103606;19136556;19617566;20398667;20811643;21450906;21880719;22027689;22041900;22183981;22461326;22914648;23053572;23507963;23584533;23602766;2373995;24643043;24690281;25153226;25502872;25813380;25888806;26969432;29557506;31844290;31871319;32350084;34357683;34433824;35051231;35154160;36700475;37793774;38345099;38369410;7655172;8333853;8598452;8611500;8649376;8920913;8972730;9042338;9295285;9394011;9417100;9435216;9531558;9915862;9988682",
        "class_list": "",
        "function": "Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling., [UniProtKB]; Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008]., [RefSeq]; GCNT3 regulated MUC13 to promote the development of hepatocellular carcinoma through the GSK3beta/beta-catenin pathway., [RefSeq, PubMed]; Long noncoding RNA BBOX1-AS1 promotes the progression of gastric cancer by regulating the miR-361-3p/Mucin 13 signaling axis., [RefSeq, PubMed]; MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Publication Status: Online-Only, [RefSeq, PubMed]; MUC13 is a good differentiation marker for gastrointestinal mucosa, [RefSeq, PubMed]; MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C., [RefSeq, PubMed]; MUC13 overexpression caused a significant increase in cell motility, invasion, proliferation, and anchorage-dependent or -independent clonogenicity while decreasing cell-cell and cell-substratum adhesion in pancreatic cancer., [RefSeq, PubMed]; Metastatic colon cancer and liver metastasis tissue samples demonstrated significantly (p<0.05) higher cytoplasmic and nuclear MUC13 expression compared with non-metastatic colon cancer and adjacent normal colon samples., [RefSeq, PubMed]; Reflux laryngitis is associated with down-regulation of mucin gene expression., [RefSeq, PubMed]; The various functional domains of MUC13 may confer oncogenic potential to MUC13 Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UWD9;Q9NXT5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9H3R2-1",
        "record_type": "protein",
        "filter_code": "0001000.1000111.100000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86W26-1",
        "uniprot_id": [
            {
                "id": "NAL10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86W26",
                "type": "external"
            }
        ],
        "mass": 75032.0,
        "length": 655,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 10",
        "gene_name": "NLRP10",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 10",
        "refseq_ac": [
            {
                "id": "NP_789791",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789791",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP10; NALP10; NOD8; PYNOD",
        "gene_names_refseq": "CLR11.1; NALP10; NLRP10; NOD8; PAN5; PYNOD",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 10; Nucleotide-binding oligomerization domain protein 8",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:338322)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "12563287;12766759;15096476;15817483;19544093;20068231;20393137;22618865;22672233;23861819;24366607;24714562;28766990;29242379;29501574;30510071;31530632;32938616;33592498;33968037;34561969;35051231;35078690;37043073;39424623",
        "class_list": "",
        "function": "Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population., [RefSeq, PubMed]; Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses., [RefSeq, PubMed]; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]., [RefSeq]; NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function. Publication Status: Online-Only, [RefSeq, PubMed]; NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-kappaB signaling in human periodontal ligament cells., [RefSeq, PubMed]; PYNOD is a novel regulator of apoptosis and inflammation., [RefSeq, PubMed]; PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins, [RefSeq, PubMed]; The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution., [RefSeq, PubMed]; This study shows that NLRP10 affects the stability of Abin-1 to control inflammatory responses, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M3C4;Q6JGT0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane",
        "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q86W26-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15069-1",
        "uniprot_id": [
            {
                "id": "NACAD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15069",
                "type": "external"
            }
        ],
        "mass": 161101.0,
        "length": 1562,
        "protein_name": "NAC-alpha domain-containing protein 1",
        "gene_name": "NACAD",
        "organism": "Human",
        "refseq_name": "NAC-alpha domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_001139806",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139806",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NACAD; KIAA0363",
        "gene_names_refseq": "NACAD",
        "protein_names_uniprotkb": "NAC-alpha domain-containing protein 1",
        "protein_names_refseq": "NAC-alpha domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23148)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "21406692;22645359;23481700;24715725;28832583;29242379;29393594;29557506;30192525;30429286;31092671;31154438;31844290;32157095;32387766;32938616;32983136;33141586;33592498;34087483;35051231;35580925;37217939;37938771;9029102",
        "class_list": "",
        "function": "May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051082 unfolded protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex",
        "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "O15069-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05976-1",
        "uniprot_id": [
            {
                "id": "MYL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05976",
                "type": "external"
            }
        ],
        "mass": 21145.0,
        "length": 194,
        "protein_name": "Myosin light chain 1/3, skeletal muscle isoform",
        "gene_name": "MYL1",
        "organism": "Human",
        "refseq_name": "myosin light chain 1/3, skeletal muscle isoform isoform 1f",
        "refseq_ac": [
            {
                "id": "NP_524144",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524144",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYL1",
        "gene_names_refseq": "CMYO14; CMYP14; MLC-1; MLC1/3; MLC1F; MLC1; MLC3F; MYL1; MYOFTA",
        "protein_names_uniprotkb": "Myosin light chain 1/3, skeletal muscle isoform; MLC1/MLC3; MLC1F/MLC3F; Myosin light chain A1/A2; Myosin light chain alkali 1/2",
        "protein_names_refseq": "A1 catalytic; A2 catalytic; MLC1/MLC3; MLC1F/MLC3F; myosin light chain 1/3, skeletal muscle isoform isoform 1f; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin, light chain 1, alkali; myosin, light polypeptide 1, alkali; skeletal, fast",
        "tax_id": 9606,
        "disease": "congenital myopathy 14 (Disease Ontology:DOID:0081346)",
        "pathway": " (hsa:4632);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "10747208;2458299;24715725;25576301;2777779;29102634;29557506;30215711;31154438;31217245;31844290;33499774;33592498;34019948;34596111;35580925;3601661;37679666",
        "class_list": "",
        "function": "Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC. Publication Status: Online-Only, [RefSeq, PubMed]; MYBPC2 and MYL1 as Significant Gene Markers for Rhabdomyosarcoma., [RefSeq, PubMed]; MYL2 as a potential predictive biomarker for rhabdomyosarcoma., [RefSeq, PubMed]; Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function., [UniProtKB, PubMed]; Our data implicate MYL1 as a crucial protein for adequate skeletal muscle function and that MYL1 deficiency is associated with severe congenital myopathy., [RefSeq, PubMed]; These results support the concept of the ATP-induced transient interaction of the essential light chain-1 N-terminus with the motor domain of the myosin head., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4N6;B2R4T6;P06741;Q6IBD5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005829 cytosol;GO:0030017 sarcomere;GO:0030016 myofibril;GO:0043292 contractile muscle fiber",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "P05976-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C2Y1-1",
        "uniprot_id": [
            {
                "id": "NBPF7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C2Y1",
                "type": "external"
            }
        ],
        "mass": 48090.0,
        "length": 421,
        "protein_name": "Putative NBPF family member NBPF7",
        "gene_name": "NBPF7P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NBPF7P; NBPF7",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative NBPF family member NBPF7; Putative neuroblastoma breakpoint family member 7",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0C2Y1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43121-1",
        "uniprot_id": [
            {
                "id": "MUC18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43121",
                "type": "external"
            }
        ],
        "mass": 71607.0,
        "length": 646,
        "protein_name": "Cell surface glycoprotein MUC18",
        "gene_name": "MCAM",
        "organism": "Human",
        "refseq_name": "cell surface glycoprotein MUC18 precursor",
        "refseq_ac": [
            {
                "id": "NP_006491",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006491",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCAM; MUC18",
        "gene_names_refseq": "CD146; HEMCAM; MCAM; METCAM; MUC18; MelCAM",
        "protein_names_uniprotkb": "Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen",
        "protein_names_refseq": "Gicerin; S-endo 1 endothelial-associated antigen; cell surface glycoprotein MUC18 precursor; cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; melanoma adhesion molecule; melanoma-associated antigen A32; melanoma-associated antigen MUC18",
        "tax_id": 9606,
        "disease": "malignant mesothelioma (Disease Ontology:DOID:1790); impotence (Disease Ontology:DOID:1875); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); uveal melanoma (Disease Ontology:DOID:6039)",
        "pathway": " (hsa:4162);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013106);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013405);  (R-HSA-9013408);  (R-HSA-9013423);  (R-HSA-9035034)",
        "pathway_count": 10,
        "publication_count": 386,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10618392;10619026;10652265;10699171;10699464;10847683;10873388;10873802;10958683;11007481;11036077;11058585;11085924;11145705;11149925;11207612;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11704860;11707441;11709656;11756552;11773441;11784792;11803464;11804587;11804589;11804590;11864571;11884391;11912491;11919634;11956649;11961559;11967128;12071859;12093360;12096337;12177196;12195014;12221077;12221096;12351724;12376551;12432077;12473120;12531887;12546821;12547822;12577064;12650940;12665586;12857875;12877655;12923183;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15169870;15302923;15339924;15342493;15485661;15507211;15542837;15579468;15601624;15611138;15728722;15814684;15850391;15858067;15866170;15897194;15944396;16002401;16081809;16112081;16116428;16184169;16217026;16243035;16243036;16339170;16467373;16473593;16492808;16507994;16519628;1660188;16630611;16636067;16702231;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16917499;16968698;17027967;17060455;17064668;17077126;17081983;17145773;17158234;17196961;17198702;17214551;17244649;17269730;17562871;17583407;17599059;17698854;17702745;17765681;17804252;17916560;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18191593;18218625;18249095;18347018;18396277;18426980;18578522;18653540;18662984;18669648;18697831;18802007;18829452;18838382;19159218;19269969;19494238;19534724;19581409;19605563;19635168;19651622;19673492;19713215;19934221;20030946;20068231;20101212;20233848;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21119010;21148482;21151158;21351730;21373644;21378159;21454492;21542010;21565175;21576392;21613211;21621533;21699497;21730051;21757538;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22475431;22608513;22665057;22673745;22734669;22790947;22869377;22911862;22970203;22992742;23087206;23090970;23096567;23200924;23209303;23255595;23288169;23434736;23481700;23572525;23584533;23707487;23718289;23757206;23870057;23870313;23940355;24086303;24102721;24128008;24190977;24259668;24335996;24352656;24623723;24659802;24859002;24933155;24960694;25024229;25211221;25425145;25428919;25645385;25668492;25673874;25704760;25721503;25746724;25795300;25862245;26016997;2602381;26129894;26371245;26529257;26628301;26887924;27117132;27145964;27216196;27278019;27481945;27555588;27566826;27600516;27713499;27806292;27852748;27986909;28112683;28114311;28196833;28356423;28486133;28584191;28947137;29089502;29146911;29242379;29358323;29382922;29557506;29741879;29776664;30379171;30853411;31105010;31389670;31611695;31871319;32203420;32350084;32488085;32938616;33214551;33592498;33968037;34019948;34078123;34725712;35051231;35251023;35289036;35318648;36215666;36335262;37074911;37153740;37217939;37856423;37993561;38665916;38682195;39261771;40596516;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8162602;8292890;8378324;8537347;8543060;8571126;8573133;8617235;8643598;8645157;8649427;8662891;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8945468;8990121;8994827;9013646;9099726;9111050;9113980;9252344;9305890;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9705280;9792683;9822598;9822605;9829970;9843499;9988689",
        "class_list": "",
        "function": "CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway., [RefSeq, PubMed]; CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway., [RefSeq, PubMed]; Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage of lymph node metastasis in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration., [UniProtKB, PubMed, PubMed]; The role of CD146 in renal disease: from experimental nephropathy to clinics. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 26,
        "disease_count": 4,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95812;Q59E86;Q6PHR3;Q6ZTR2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030335 positive regulation of cell migration;GO:0003094 glomerular filtration;GO:0061042 vascular wound healing",
        "synthesized_glycan_count": 0,
        "hit_score": 42.4,
        "record_id": "P43121-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100100010001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55160-1",
        "uniprot_id": [
            {
                "id": "NCKPL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55160",
                "type": "external"
            }
        ],
        "mass": 128153.0,
        "length": 1127,
        "protein_name": "Nck-associated protein 1-like",
        "gene_name": "NCKAP1L",
        "organism": "Human",
        "refseq_name": "nck-associated protein 1-like isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001171905",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171905",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCKAP1L; HEM1",
        "gene_names_refseq": "HEM1; IMD72; NCKAP1L",
        "protein_names_uniprotkb": "Nck-associated protein 1-like; Hematopoietic protein 1; Membrane-associated protein HEM-1",
        "protein_names_refseq": "hematopoietic protein 1; membrane-associated protein hem-1; nck-associated protein 1-like isoform 2; nck-associated protein 1-like",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); immunodeficiency 72 (Disease Ontology:DOID:0112015)",
        "pathway": " (hsa:3071);  (R-HSA-2029482);  (R-HSA-4420097);  (R-HSA-5663213);  (R-HSA-6798695);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013423);  (R-HSA-9664422)",
        "pathway_count": 9,
        "publication_count": 429,
        "publication_id_list": "10037737;10075701;10207622;10219243;10232922;10395673;10464238;10490598;10496324;10508610;10523665;10523675;10526156;10559246;10559936;10579713;10618392;10677529;10692392;10699171;10699464;10724160;10744763;10749680;10781580;10847683;10873802;10878810;10958683;10995437;11007481;11058585;11085924;11145705;11149925;11157975;11231582;11237011;11276226;11278486;11329366;11340081;11373293;11396949;11431473;11432776;11553796;11584276;11672528;11695992;11696015;11704860;11707441;11747816;11756552;11773441;11803464;11804587;11804589;11804590;11829459;11854399;11884391;11912491;11919634;11956649;11961559;12055636;12071859;12093360;12096337;12105426;12134158;12189515;12195014;12213210;12214271;12215529;12221096;12235133;12351724;12391143;12432077;12464388;12531887;12546821;12547822;12650940;12660731;12665586;12743368;12810700;12820653;12857875;12877655;12923183;1314888;14512443;14514689;1464587;14675773;14676198;14718541;14724572;15023524;15026417;15033976;15040784;15064355;15107133;15133129;15147912;15169870;15247219;15302923;15308668;15339924;15342493;15452139;15485661;15507211;15542837;15579468;15601624;15611138;15657136;15688067;15695828;15728722;15814684;15850391;15858067;15897194;15962004;16002401;16081809;16112081;16116428;16184169;16243035;16243036;16262445;16336962;16417406;16473593;16492808;16507994;16519628;16546099;1660188;16636067;16641196;16702231;16760434;16762923;16777452;16777849;16862148;16880808;16896804;16914516;16966330;16968698;17030947;17060455;17077126;17145773;17158234;17188549;17196961;17199126;17202194;17214551;17237347;17244649;17269730;17293873;17308335;17583407;17599059;17686471;17696648;17698854;17702745;17765681;17804252;17976533;18006505;18045877;18056264;18070890;18191593;18218625;18249095;18347018;18391171;18396277;18426980;18653540;18662984;18697831;18838382;18991276;19230644;19267251;19269969;1932118;19494238;19534724;19605563;19673492;19713215;19741094;19934221;19955216;20400958;20460433;20658524;20679435;20810653;20969869;21037092;21148482;21151158;21378159;21419341;21445309;21542010;21565175;21613211;21730051;21865595;21989057;22004470;22096251;22298643;22327215;22407364;22424782;22475431;22544926;22608513;22689825;22734669;22970203;23209303;23216836;23255595;23288169;23434736;23481700;23572525;23650620;23675550;23707487;23718289;23757206;23870057;23940355;24086303;24259668;24335996;24352656;24397554;24623723;24714562;24715725;2474607;24859002;24933155;24960694;25024229;25211221;25428919;25576301;25704760;25721503;25795300;25862245;25880248;25892735;26016997;26129894;26154972;26375851;26529257;26628301;26728094;26811146;26887924;26992070;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27806292;27846572;27862975;27920218;28114311;28196833;28218747;28228285;28356423;28832583;28834231;28904123;29089502;29242379;29358323;29382922;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30001391;30315122;30410026;30429286;30524438;30853411;31092671;31154438;31217245;31389670;31530632;31844290;31848261;31871319;31937595;31998317;32157095;32203420;32265295;32350084;32357974;32387766;32488085;32502341;32647003;32733620;32766723;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33691108;33717175;33912179;33936100;33968037;34211107;34357683;34509645;34898354;34932366;35051231;35561310;35580925;35869404;36010968;36284347;37938771;38844271;7479768;7509446;7512369;7559638;7643388;7673236;7721814;7753201;7835339;7848918;8021274;8107774;8537347;8543060;8617235;8643598;8645157;8662891;8692836;8756646;8769096;8798539;8805223;8809042;8810315;8816443;8939998;8986718;8990121;8994827;9013646;9099726;9113980;9182576;9252344;9305890;9393975;9398617;9438849;9472046;9490638;9497316;9582072;9600938;9659915;9670022;9705280;9792683;9799231;9822598;9843499;9883880;9885284;9988689",
        "class_list": "",
        "function": "Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions. Review article, [RefSeq, PubMed]; Long non-coding RNA PVT1/microRNA miR-3127-5p/NCK-associated protein 1-like axis participates in the pathogenesis of abdominal aortic aneurysm by regulating vascular smooth muscle cells., [RefSeq, PubMed]; NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation., [RefSeq, PubMed]; Potential predictive value of immune-related genes FUCA1 and NCKAP1L for osteosarcoma metastasis., [RefSeq, PubMed]; Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses. Publication Status: Online-Only, [RefSeq, PubMed]; The Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile neutrophil, [RefSeq, PubMed]; This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]., [RefSeq]; Versatile Hem-1-containing complexes coordinate diverse regulatory signals at the leading edge of polarized neutrophils, including but not confined to those involving Verprolin-homologous protein-dependent actin polymerization, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DUT5;Q52LW0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0030295 protein kinase activator activity;GO:0044877 protein-containing complex binding;GO:1904841 TORC2 complex binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0032700 negative regulation of interleukin-17 production;GO:0006935 chemotaxis;GO:0016477 cell migration;GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 43.0,
        "record_id": "P55160-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13203-1",
        "uniprot_id": [
            {
                "id": "MYBPH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13203",
                "type": "external"
            }
        ],
        "mass": 52050.0,
        "length": 477,
        "protein_name": "Myosin-binding protein H",
        "gene_name": "MYBPH",
        "organism": "Human",
        "refseq_name": "myosin-binding protein H",
        "refseq_ac": [
            {
                "id": "NP_004988",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004988",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYBPH",
        "gene_names_refseq": "MYBPH",
        "protein_names_uniprotkb": "Myosin-binding protein H; H-protein; MyBP-H",
        "protein_names_refseq": "H-protein; myBP-H; myosin-binding protein H",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763)",
        "pathway": " (hsa:4608)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "19536175;22085929;22424782;23068101;23481700;24184715;25576301;26969327;26992070;28228285;28778945;28904123;29242379;29557506;31292467;31844290;31848261;32357974;32387766;32938616;33141586;33298915;34509645;35051231;8486381",
        "class_list": "",
        "function": "Binds to myosin; probably involved in interaction with thick myofilaments in the A-band., [UniProtKB]; MYBPH inhibited assembly competence-conferring phosphorylation of the myosin regulatory light chain (RLC) as well as activating phosphorylation of LIM domain kinase, unexpectedly through its direct physical interaction with Rho kinase 1, [RefSeq, PubMed]; MyBP-H expression signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of amyotrophic lateral sclerosis., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; These results suggest that MYBPH inhibits RLC and NMHC IIA, independent components of NM IIA, and negatively regulates actomyosin organization at 2 distinct steps, resulting in firm inhibition of NM IIA assembly., [RefSeq, PubMed]; Variation in MYBPH can modulate the severity of hypertrophy in hypertrophic cardiomyopathy patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16886;Q86YC5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0032982 myosin filament;GO:0031430 M band",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization;GO:0006942 regulation of striated muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q13203-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53F19-1",
        "uniprot_id": [
            {
                "id": "NCBP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53F19",
                "type": "external"
            }
        ],
        "mass": 70593.0,
        "length": 620,
        "protein_name": "Nuclear cap-binding protein subunit 3",
        "gene_name": "NCBP3",
        "organism": "Human",
        "refseq_name": "nuclear cap-binding protein subunit 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001107590",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107590",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCBP3; C17orf85",
        "gene_names_refseq": "C17orf85; ELG; HSA277841; NCBP3",
        "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 3; Protein ELG",
        "protein_names_refseq": "CTD-3195I5.1; CTD-3195I5.5; nuclear cap-binding protein subunit 3 isoform 1; nuclear cap-binding protein subunit 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55421)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11237011;17081983;18220336;18669648;20068231;21406692;23186163;24275569;24714562;24715725;25218447;25576301;26382858;26992070;27600516;27846572;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;30410026;30429286;30524438;31844290;32157095;32387766;32488085;32502341;32897882;32938616;32960270;32960271;32983136;33298915;33592498;33691108;33717175;33912179;33968037;33981976;34171305;34211107;34932366;35051231;35580925;36010968;36215666;36241641;36284347",
        "class_list": "",
        "function": "Affinity proteomic dissection of the human nuclear cap-binding complex interactome., [RefSeq, PubMed]; Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858)., [UniProtKB, PubMed]; NCBP3 binds mRNA, associates with components of the mRNA processing machinery and contributes to poly(A) RNA export. Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; NCBP3 positively impacts mRNA biogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWG7;Q7L406;Q96FK1;Q9NXZ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034518 RNA cap binding complex",
        "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0051607 defense response to virus;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0042789 mRNA transcription by RNA polymerase II;GO:0006370 7-methylguanosine mRNA capping",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q53F19-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6J4K2-1",
        "uniprot_id": [
            {
                "id": "NCLX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6J4K2",
                "type": "external"
            }
        ],
        "mass": 64231.0,
        "length": 584,
        "protein_name": "Mitochondrial sodium/calcium exchanger protein",
        "gene_name": "SLC8B1",
        "organism": "Human",
        "refseq_name": "mitochondrial sodium/calcium exchanger protein isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001317395",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317395",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC8B1; NCKX6; NCLX; SLC24A6",
        "gene_names_refseq": "NCKX6; NCLX; SLC24A6; SLC8B1",
        "protein_names_uniprotkb": "Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 member 6; Solute carrier family 8 member B1",
        "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 6; mitochondrial sodium/calcium exchanger protein isoform 2 precursor; mitochondrial sodium/calcium exchanger protein; sodium/calcium exchanger protein, mitochondrial; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; solute carrier family 24 member 6; solute carrier family 8 (sodium/lithium/calcium exchanger), member B1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80024);  (R-HSA-425561);  (R-HSA-8949215)",
        "pathway_count": 3,
        "publication_count": 77,
        "publication_id_list": "10.1101/2023.09.13.557529;10662833;11237011;11294880;12379639;12438411;14625281;15060069;15904662;16357253;17178908;18166528;18628306;19797662;20018762;20058876;20693986;21685886;21685888;21720385;22829870;23056385;23409044;23716663;23755363;23900286;24162235;24190977;24231807;24344246;24503055;24560927;24898248;25077561;25171321;25565209;25576301;25753332;26440884;26976564;26992070;27099988;27669901;27846572;28130126;28218747;28219928;28649982;28904123;29393594;29557506;29632046;29789417;31154438;31217245;31844290;32157095;32387766;32938616;33392160;33592498;33968037;33981976;34087483;34357683;34942149;34944520;35051231;35580925;35887296;36215666;36241641;36552754;37938771;40200126;7399049;9856482",
        "class_list": "",
        "function": "CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca[2+] via Mitochondrial NCLX. Publication Status: Online-Only, [RefSeq, PubMed]; Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic., [RefSeq, PubMed]; Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:15060069, PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28130126, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Mitochondrial calcium export is ph-dependent (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069, PubMed:28130126). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; NCKX6 is a novel member of the Na+/Ca2+ exchanger superfamily, [RefSeq, PubMed]; NCLX catalyzes active Li(+)/Ca(2+) exchange., [RefSeq, PubMed]; Physiological and Pathophysiological Roles of Mitochondrial Na(+)-Ca(2+) Exchanger, NCLX, in Hearts. Review article Publication Status: Online-Only, [RefSeq, PubMed]; SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]., [RefSeq]; Spatial and Functional Crosstalk between the Mitochondrial Na(+)-Ca(2+) Exchanger NCLX and the Sarcoplasmic Reticulum Ca(2+) Pump SERCA in Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NP50;Q4KMS9;Q6J4K1;Q9H6I8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005432 calcium:sodium antiporter activity;GO:0015368 calcium:monoatomic cation antiporter activity;GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential;GO:0015297 antiporter activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0070588 calcium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q6J4K2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZUF6-1",
        "uniprot_id": [
            {
                "id": "NC336_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZUF6",
                "type": "external"
            }
        ],
        "mass": 20903.0,
        "length": 198,
        "protein_name": "Putative uncharacterized protein encoded by LINC00336",
        "gene_name": "LINC00336",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "LINC00336; C6orf227; NCRNA00336",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein encoded by LINC00336",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "25576301;26992070;30833945;31217245;31844290;32897882;34087483",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q6ZUF6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z5P9-1",
        "uniprot_id": [
            {
                "id": "MUC19_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z5P9",
                "type": "external"
            }
        ],
        "mass": 805253.0,
        "length": 8384,
        "protein_name": "Mucin-19",
        "gene_name": "MUC19",
        "organism": "Human",
        "refseq_name": "mucin-19 precursor",
        "refseq_ac": [
            {
                "id": "NP_775871",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775871",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC19",
        "gene_names_refseq": "MUC-19; MUC19",
        "protein_names_uniprotkb": "Mucin-19; MUC-19",
        "protein_names_refseq": "mucin-19 precursor; mucin-19",
        "tax_id": 9606,
        "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894)",
        "pathway": " (hsa:283463);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 85,
        "publication_id_list": "10330415;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11283017;11304796;11606584;11821425;12464682;12855678;12882755;1329093;14656219;15466199;15486459;15560372;15599692;15620693;15687324;16151858;16251947;16319059;17050534;17113861;17667140;18184611;18426393;18490740;18537974;18776906;18818202;19617566;21075863;21880719;22041900;22183981;22461326;23053572;23507963;23602766;2373995;24643043;25153226;25645385;27869121;29242379;29393594;29557506;30139516;30192525;30429286;30779550;31092671;31154438;31530632;32387766;33392160;33633747;34082777;34087483;34211107;34509645;35051231;35851588;36010968;38253038;38757482;39894887;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach., [RefSeq, PubMed]; Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Identification, cloning and expression of mucin 19; expression of this gene is restricted to the mucous cells of various glandular tissues, [RefSeq, PubMed]; METTL3 aggravates cell damage induced by Streptococcus pneumoniae via the NEAT1/CTCF/MUC19 axis., [RefSeq, PubMed]; May function in ocular mucus homeostasis., [UniProtKB, PubMed]; Results suggest that MUC19 is not a major component in human saliva., [RefSeq, PubMed]; The findings suggest an oncogenic role for hsa_circ_0007534 in breast cancer by acting as a miR-593 sponge to promote MUC19 expression., [RefSeq, PubMed]; This gene encodes a member of the gel-forming mucin protein family. Mucin family members are glycoproteins that have tandem repeats which are extensively O-glycosylated. The structural features of mucin proteins are responsible for the gel-like properties of mucus. The encoded protein may be involved in disruption of the ocular surface in Sjogren syndrome. [provided by RefSeq, Apr 2014]., [RefSeq]",
        "predicted_glycosites": 12,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 12,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 26,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3CIG0;Q8NA85",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q7Z5P9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.000010.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86W24-1",
        "uniprot_id": [
            {
                "id": "NAL14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86W24",
                "type": "external"
            }
        ],
        "mass": 124733.0,
        "length": 1093,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 14",
        "gene_name": "NLRP14",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 14",
        "refseq_ac": [
            {
                "id": "NP_789792",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789792",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP14; NALP14; NOD5",
        "gene_names_refseq": "CLR11.2; GC-LRR; NALP14; NLRP14; NOD5; PAN8",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 14; Nucleotide-binding oligomerization domain protein 5",
        "protein_names_refseq": "NACHT, LRR and PYD containing protein 14; NACHT, LRR and PYD domains-containing protein 14; NACHT, leucine rich repeat and PYD containing 14; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:338323)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "12563287;12766759;16931801;16959974;19074885;20403135;25004977;25403012;25576301;25892735;27535533;28423339;29557506;31530632;33091337;35051231;35580925;38060382;38253038",
        "class_list": "",
        "function": "Data show that NLRP14 expression was rapidly downregulated after fertilization., [RefSeq, PubMed]; May be involved in inflammation and spermatogenesis., [UniProtKB]; NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Our data suggest that NALP14 has a function in spermatogenesis and that mutations in this gene might cause spermatogenic failure., [RefSeq, PubMed]; The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]., [RefSeq]; This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7RTR6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q86W24-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86W28-1",
        "uniprot_id": [
            {
                "id": "NALP8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86W28",
                "type": "external"
            }
        ],
        "mass": 119430.0,
        "length": 1048,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 8",
        "gene_name": "NLRP8",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 8 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001303929",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303929",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP8; NALP8; NOD16; PAN4",
        "gene_names_refseq": "CLR19.2; NALP8; NLRP8; NOD16; PAN4",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 8; Nucleotide-binding oligomerization domain protein 16; PYRIN and NACHT-containing protein 4",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 8 isoform 2; NACHT, LRR and PYD domains-containing protein 8; NACHT, leucine rich repeat and PYD containing 8; PYRIN and NACHT-containing protein 4; nucleotide-binding oligomerization domain protein 16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126205)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "12563287;12766759;16959974;19074885;20403135;24715725;29557506;35051231",
        "class_list": "",
        "function": "Involved in inflammation., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; This gene encodes a member of the nucleotide-binding oligomerization domain/ leucine rich repeat/ pyrin domain containing (NLRP) subfamily, which belongs to the Nod-like receptor family of proteins. NLRP genes play roles in the mammalian innate immune system through inflammasome formation and activation of caspases. In addition, NLRP genes have been found to function during mammalian reproduction. Consistent with a function during human preimplantation development, this gene is expressed at high levels in oocytes with decreased levels in embryos. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7RTR4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q86W28-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86XG9-1",
        "uniprot_id": [
            {
                "id": "NBPF5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86XG9",
                "type": "external"
            }
        ],
        "mass": 40546.0,
        "length": 351,
        "protein_name": "Putative NBPF family member NBPF5",
        "gene_name": "NBPF5P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NBPF5P; NBPF5",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative NBPF family member NBPF5; Putative neuroblastoma breakpoint family member 5",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "16079250",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q86XG9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86Y39-1",
        "uniprot_id": [
            {
                "id": "NDUAB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86Y39",
                "type": "external"
            }
        ],
        "mass": 14852.0,
        "length": 141,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11",
        "gene_name": "NDUFA11",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180304",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180304",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFA11",
        "gene_names_refseq": "B14.7; CI-B14.7; MC1DN14; NDUFA11",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; CI-B14.7; Complex I-B14.7; NADH-ubiquinone oxidoreductase subunit B14.7",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform 2; NADH-ubiquinone oxidoreductase subunit B14.7; complex I B14.7 subunit",
        "tax_id": 9606,
        "disease": "nuclear type mitochondrial complex I deficiency 14 (Disease Ontology:DOID:0112094); communication disorder (Disease Ontology:DOID:2033)",
        "pathway": " (hsa:126328);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 111,
        "publication_id_list": "10327278;11220739;11237011;11695836;12231006;12611891;12665801;12837546;1327877;14741580;15250827;16230336;17033964;17308301;17936786;18306244;186667;19752196;20406883;20552642;20858599;21924235;22617051;22645359;23150584;23270816;23553477;23564345;23747254;239860;24191001;24366607;25418920;25469497;25564869;25576301;25678554;25892735;26154972;26754738;26811146;26929215;26992070;27499296;27543614;27600516;27626371;27846572;27920218;28063628;28218747;28228285;28510447;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30484775;31217245;31530632;31666358;31844290;31848261;31866046;31998317;32157095;32161166;32265295;32320651;32357974;32387766;32488085;32502341;32938616;32983136;33298915;33592498;33633747;33691108;33879611;33882309;33912179;33968037;34357683;34509645;34561969;34932366;35051231;35318648;35333655;35561310;35580925;35614220;36010968;36241641;37938771;38199007;4288886;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study identified a splice-site mutation in the NDUFA11 gene in six mitochondrial complex I deficiency patients from three unrelated families, [RefSeq, PubMed]; This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JT23;Q6ZS66",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "Q86Y39-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4I1-1",
        "uniprot_id": [
            {
                "id": "MYO5A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4I1",
                "type": "external"
            }
        ],
        "mass": 215405.0,
        "length": 1855,
        "protein_name": "Unconventional myosin-Va",
        "gene_name": "MYO5A",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Va isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000250",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000250",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO5A; MYH12",
        "gene_names_refseq": "GS1; MYH12; MYO5A; MYO5; MYR12",
        "protein_names_uniprotkb": "Unconventional myosin-Va; Dilute myosin heavy chain, non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin",
        "protein_names_refseq": "dilute myosin heavy chain, non-muscle; myosin VA (heavy chain 12, myoxin); myosin V; myosin, heavy polypeptide kinase; myosin-12; myosin-Va; myoxin; unconventional myosin-Va isoform 1; unconventional myosin-Va",
        "tax_id": 9606,
        "disease": "Griscelli syndrome (Disease Ontology:DOID:0060831); Griscelli syndrome type 1 (Disease Ontology:DOID:0060832)",
        "pathway": " (hsa:4644);  (R-HSA-1445148);  (R-HSA-2029482);  (R-HSA-264876);  (R-HSA-9664422);  (R-HSA-9824585)",
        "pathway_count": 6,
        "publication_count": 216,
        "publication_id_list": "10219243;10448864;10496324;10521251;10559936;10587587;10704277;10724160;10733681;10781580;10878810;10995437;11157975;11231582;11237011;11276226;11278486;11329366;11340081;11462236;11493706;11532965;11553796;11707400;11747816;11804587;11829459;11854399;11856727;11904301;11964381;12055636;12058346;12062444;12105426;12189515;12213210;12235133;12743368;12897212;1314888;1321344;14617756;14676198;14704853;15040784;1528899;15331542;1537333;1537334;15452139;15543135;15657136;15695812;15729346;15878854;15919790;15971998;16158220;16158222;16262445;16303920;16407158;16546099;16641196;16702231;16714477;16880201;16880808;16984975;17081983;17182843;17188549;17202194;17308335;17369524;17515613;17952075;17995453;18070890;18391171;18452278;18483556;18669648;18697795;18812475;19013499;19252894;19389701;19413330;19664995;19717472;19741094;19955216;20068231;20308425;20631154;20701589;20837646;20937701;21037092;21091435;21145486;21308844;21419341;21454505;21454690;21713314;21907143;22908308;23186163;23481700;23675550;24267888;24714562;24715725;2474607;25091901;25418920;2550440;25576301;25645385;25880248;25892735;26375851;26694611;2669954;26929215;26992070;27600516;27846572;28218747;2822027;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30515787;30532555;30779550;31154438;31184304;31217245;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32723473;32735728;32938616;32983136;33100333;33141586;33298915;33485965;33537174;33633747;33727250;33912179;33968037;34019948;34087483;34171305;34185709;34357683;34509645;34680875;34935414;35051231;35580127;35580925;36010968;36215666;36241641;37938771;38129784;3896518;7626024;7813420;7835087;7848918;8094051;8188282;8306979;8664345;8809042;8916141;8921401;8986718;9166668;9207796;9207799;9600938;9631292;9705280;9758418;9799231;9843499;9883880;9885284",
        "class_list": "",
        "function": "Identification of three predictors of gastric cancer progression and prognosis., [RefSeq, PubMed]; LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade. Publication Status: Online-Only, [RefSeq, PubMed]; MYO5A Frameshift Variant in a Miniature Dachshund with Coat Color Dilution and Neurological Defects Resembling Human Griscelli Syndrome Type 1. Publication Status: Online-Only, [RefSeq, PubMed]; MYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Modeling myosin Va liposome transport through actin filament networks reveals a percolation threshold that modulates transport properties., [RefSeq, PubMed]; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1) and neuroectodermal melanolysosomal disease, or Elejalde disease. [provided by RefSeq, Sep 2023]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "monitoring",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MZC5;O60653;Q07902;Q16249;Q9UE30;Q9UE31",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0030426 growth cone",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 21.9,
        "record_id": "Q9Y4I1-1",
        "record_type": "protein",
        "filter_code": "0100000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6X6-1",
        "uniprot_id": [
            {
                "id": "MYO16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6X6",
                "type": "external"
            }
        ],
        "mass": 206129.0,
        "length": 1858,
        "protein_name": "Unconventional myosin-XVI",
        "gene_name": "MYO16",
        "organism": "Human",
        "refseq_name": "unconventional myosin-XVI isoform 2",
        "refseq_ac": [
            {
                "id": "NP_055826",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055826",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO16; KIAA0865; MYO16B; NYAP3",
        "gene_names_refseq": "MYAP3; MYO16; MYR8; Myo16b; NYAP3; PPP1R107",
        "protein_names_uniprotkb": "Unconventional myosin-XVI; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; Unconventional myosin-16",
        "protein_names_refseq": "MYO16 variant protein; myosin heavy chain Myr 8; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3; protein phosphatase 1, regulatory subunit 107; unconventional myosin-16; unconventional myosin-XVI isoform 2; unconventional myosin-XVI",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23026)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;19913121;20201926;21248752;24141571;25892735;25902260;28228285;28514659;29557506;29769354;30315122;31217245;31530632;31844290;32488085;32938616;32983136;33298915;33912179;33968037;34850884;35051231;36010968;36241641;37217939",
        "class_list": "",
        "function": "KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]., [RefSeq]; This study suggest that common variation within MYO16 may contribute to the genetic liability to schizophrenia., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 72,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8Y0;A8MTX3;Q5VYX4;Q5VYX5;Q5VYX6;Q6ZS13;Q8N3C2;Q8N948",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0019903 protein phosphatase binding;GO:0003774 cytoskeletal motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016459 myosin complex",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0048812 neuron projection morphogenesis;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0021549 cerebellum development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9Y6X6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UGF7-1",
        "uniprot_id": [
            {
                "id": "O12D3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UGF7",
                "type": "external"
            }
        ],
        "mass": 35791.0,
        "length": 316,
        "protein_name": "Olfactory receptor 12D3",
        "gene_name": "OR12D3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 12D3",
        "refseq_ac": [
            {
                "id": "NP_112221",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112221",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR12D3",
        "gene_names_refseq": "OR12D3; hs6M1-27",
        "protein_names_uniprotkb": "Olfactory receptor 12D3; Hs6M1-27; Olfactory receptor OR6-27",
        "protein_names_refseq": "olfactory receptor 12D3; olfactory receptor OR6-27",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81797);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "12637542;14983052;16959974;18160138;19851445;20205591;20466734;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[J Infect Dis. 2010 Aug 15;202(3):501], [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BDZ1;Q5SQI8;Q6IF23",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9UGF7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O76001-1",
        "uniprot_id": [
            {
                "id": "OR2J3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O76001",
                "type": "external"
            }
        ],
        "mass": 34950.0,
        "length": 311,
        "protein_name": "Olfactory receptor 2J3",
        "gene_name": "OR2J3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2J3",
        "refseq_ac": [
            {
                "id": "NP_001005216",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005216",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2J3",
        "gene_names_refseq": "6M1-3; C3HEXS; HS6M1-3; OR2J3; OR6-16; OR6-6; OR6.3.6; ORL671",
        "protein_names_uniprotkb": "Olfactory receptor 2J3; Hs6M1-3; OR6-6; Olfactory receptor 6-6; Olfactory receptor OR6-16",
        "protein_names_refseq": "olfactory receptor 2J3; olfactory receptor 6-6; olfactory receptor OR6-16",
        "tax_id": 9606,
        "disease": "obsolete c3hex, ability to smell (MONDO:MONDO:0044281)",
        "pathway": " (hsa:442186);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 25,
        "publication_id_list": "10460249;11237011;14983052;15598656;17601748;17873857;17973576;19474308;19581598;22714804;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;27939274;28656349;29235485;31040214;31974307;32066986;35051231",
        "class_list": "",
        "function": "OR2J3 activation induces apoptosis and inhibits cell proliferation and migration in long-term stimulus experiments with helional., [RefSeq, PubMed]; Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'., [UniProtKB, PubMed]; This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]., [RefSeq]; Two amino acid substitutions, T113A and R226Q, impaired the ability of OR2J3 to respond to cis-3-hexen-1-ol, and together these two substitutions effectively abolished the response to the compound., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0UY52;B9EH11;Q5SUJ7;Q6IF25;Q96R15;Q9GZK5;Q9GZL4;Q9GZL5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "O76001-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGC9-1",
        "uniprot_id": [
            {
                "id": "O11H4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGC9",
                "type": "external"
            }
        ],
        "mass": 36886.0,
        "length": 324,
        "protein_name": "Olfactory receptor 11H4",
        "gene_name": "OR11H4",
        "organism": "Human",
        "refseq_name": "olfactory receptor 11H4",
        "refseq_ac": [
            {
                "id": "NP_001004479",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004479",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR11H4",
        "gene_names_refseq": "OR11H4; OR14-36",
        "protein_names_uniprotkb": "Olfactory receptor 11H4; Olfactory receptor OR14-36",
        "protein_names_refseq": "olfactory receptor 11H4; olfactory receptor OR14-36",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390442);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 25,
        "publication_id_list": "10460249;11237011;14983052;15598656;17601748;17873857;17973576;18491316;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986;35494241;36241641",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNQ4;Q6IF07",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q8NGC9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH09-1",
        "uniprot_id": [
            {
                "id": "OR8S1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH09",
                "type": "external"
            }
        ],
        "mass": 39645.0,
        "length": 359,
        "protein_name": "Olfactory receptor 8S1",
        "gene_name": "OR8S1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR8S1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 8S1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:341568);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "11237011;23481700;24800820;27515280;29557506;31844290;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NH09-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NF89-1",
        "uniprot_id": [
            {
                "id": "OR6C6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NF89",
                "type": "external"
            }
        ],
        "mass": 35963.0,
        "length": 314,
        "protein_name": "Olfactory receptor 6C6",
        "gene_name": "OR6C6",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6C6",
        "refseq_ac": [
            {
                "id": "NP_001005493",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005493",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6C6",
        "gene_names_refseq": "OR6C6",
        "protein_names_uniprotkb": "Olfactory receptor 6C6",
        "protein_names_refseq": "olfactory receptor 6C6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283365);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "24800820;27515280;31974307;32066986;32387766;32938616",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A6NF89-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UM07-1",
        "uniprot_id": [
            {
                "id": "PADI4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UM07",
                "type": "external"
            }
        ],
        "mass": 74079.0,
        "length": 663,
        "protein_name": "Protein-arginine deiminase type-4",
        "gene_name": "PADI4",
        "organism": "Human",
        "refseq_name": "protein-arginine deiminase type-4",
        "refseq_ac": [
            {
                "id": "NP_036519",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036519",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PADI4; PAD4; PADI5; PDI5",
        "gene_names_refseq": "PAD4; PADI4; PADI5; PAD; PDI4; PDI5",
        "protein_names_uniprotkb": "Protein-arginine deiminase type-4; 3.5.3.15; HL-60 PAD; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV",
        "protein_names_refseq": "HL-60 PAD; PADI-H protein; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; protein-arginine deiminase type IV; protein-arginine deiminase type-4",
        "tax_id": 9606,
        "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)",
        "pathway": " (hsa:23569);  (R-HSA-3247509)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10488123;11069618;11237011;11435484;12392711;12393868;12416996;12833157;15077293;15087120;15247907;15338034;15339660;15345777;15629448;15731352;16567635;17002273;17303166;18209087;19153223;20201080;21245532;21882827;22004374;25622091;25892735;26154972;26992070;27543614;27862975;28422163;28574339;28832583;29242379;29557506;29789417;30379171;30429286;31154438;31844290;31848261;32157095;32170015;32983136;33123756;34171305;34509645;35051231;35580925;36241641;36284347;37751115;37759458;38151017;38395360;38878927",
        "class_list": "",
        "function": "A PADI4 susceptibility haplotype associated with RA in a Japanese population is not associated with RA in a UK population but other genes involved in the citrullinating pathway remain strong candidate GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:19153223, PubMed:21245532, PubMed:25622091). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:18209087). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (PubMed:15345777). Involved for the formation of neutrophil extracellular traps (NETs) by mediating citrullination of histone H3 and initiating decondensation of chromatin and nuclear membrane rupture (PubMed:19153223, PubMed:25622091, PubMed:28574339, PubMed:32170015). NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation (PubMed:19153223). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (PubMed:15731352)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells., [RefSeq, PubMed]; HRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB p50., [RefSeq, PubMed]; Identified a haplotype of PADI4 associated with susceptibility to rheumatoid arthritis that affected stability of transcripts and was associated with levels of antibody to citrullinated peptide in sera from individuals with rheumatoid arthritis, [RefSeq, PubMed]; Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi., [RefSeq, PubMed]; Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients. Publication Status: Online-Only, [RefSeq, PubMed]; PAD V is localized in the nucleus in Hela cells, [RefSeq, PubMed]; Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population., [RefSeq, PubMed]; This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K392;B2RBW0;Q5VTZ8;Q70SX4",
        "ec_number_list": [
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0140794 histone arginine deiminase activity;GO:0140795 histone H3R2 arginine deiminase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0036211 protein modification process;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q9UM07-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B2RN74-1",
        "uniprot_id": [
            {
                "id": "O11HC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B2RN74",
                "type": "external"
            }
        ],
        "mass": 36530.0,
        "length": 326,
        "protein_name": "Olfactory receptor 11H12",
        "gene_name": "OR11H12",
        "organism": "Human",
        "refseq_name": "olfactory receptor 11H12",
        "refseq_ac": [
            {
                "id": "NP_001013372",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013372",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR11H12",
        "gene_names_refseq": "OR11H12",
        "protein_names_uniprotkb": "Olfactory receptor 11H12",
        "protein_names_refseq": "olfactory receptor 11H12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440153)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "32387766;33592498",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "B2RN74-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14718-1",
        "uniprot_id": [
            {
                "id": "OPSX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14718",
                "type": "external"
            }
        ],
        "mass": 37423.0,
        "length": 337,
        "protein_name": "Visual pigment-like receptor peropsin",
        "gene_name": "RRH",
        "organism": "Human",
        "refseq_name": "visual pigment-like receptor peropsin",
        "refseq_ac": [
            {
                "id": "NP_006574",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006574",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RRH",
        "gene_names_refseq": "RRH",
        "protein_names_uniprotkb": "Visual pigment-like receptor peropsin",
        "protein_names_refseq": "peropsin; visual pigment-like receptor peropsin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10692);  (R-HSA-418594);  (R-HSA-419771)",
        "pathway_count": 3,
        "publication_count": 33,
        "publication_id_list": "10234000;10581022;10632589;11007482;11237011;12120503;12542842;1302020;14623103;1531728;1557123;15674243;15951850;16634148;16923326;17167409;18434541;18577758;20332099;2534964;2748346;2834384;28832583;2937147;29476064;31844290;32488085;6589631;7937899;7947717;8015379;8406495;9275222",
        "class_list": "",
        "function": "By using chimeric mutant peropsins, it was found that peropsin potentially generates an 'active form' that drives G-protein signalling in the dark by binding to all-trans-retinal, and that the active form photo-converts to an inactive form containing 11-cis-retinal. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock, Victor [added]; Tischfield, Jay A [added]], [RefSeq, PubMed]; Opsin-family protein localized to the apical microvilli of the retinal pigment epithelium (RPE), where it may participate in retinoid exchange between photoreceptors and RPE or light-dependent retinoid processing. Although it possesses the structural features of a GPCR, no evidence for canonical G protein activation in vivo has been reported., [UniProtKB, UniProtKB]; Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. [provided by RefSeq, Jul 2008]., [RefSeq]; Peropsin gene is not a common cause of retinitis pigmentosa or some related retinal degenerations, at least in the set of patients we analyzed. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4V2;Q7RTS4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008020 G protein-coupled photoreceptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "O14718-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43749-1",
        "uniprot_id": [
            {
                "id": "OR1F1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43749",
                "type": "external"
            }
        ],
        "mass": 34866.0,
        "length": 312,
        "protein_name": "Olfactory receptor 1F1",
        "gene_name": "OR1F1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1F1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_036492",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036492",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1F1; OLFMF; OR1F10; OR1F4; OR1F5; OR1F6; OR1F7; OR1F8; OR1F9",
        "gene_names_refseq": "OLFMF; OR16-36; OR16-37; OR16-88; OR16-89; OR16-90; OR1F10; OR1F13P; OR1F1; OR1F4; OR1F5; OR1F6; OR1F7; OR1F8; OR1F9; OR3-145; ORL1023",
        "protein_names_uniprotkb": "Olfactory receptor 1F1; OR16-35; Olfactory receptor 16-35; Olfactory receptor 1F10; Olfactory receptor 1F4; Olfactory receptor 1F5; Olfactory receptor 1F6; Olfactory receptor 1F7; Olfactory receptor 1F8; Olfactory receptor 1F9; Olfactory receptor OR16-4",
        "protein_names_refseq": "olfactory receptor 1F1 isoform 1; olfactory receptor, family 1, subfamily F, member 10; olfactory receptor, family 1, subfamily F, member 13 pseudogene; olfactory receptor, family 1, subfamily F, member 4; olfactory receptor, family 1, subfamily F, member 5; olfactory receptor, family 1, subfamily F, member 6; olfactory receptor, family 1, subfamily F, member 7; olfactory receptor, family 1, subfamily F, member 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4992);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231;9288094;9500546;9653642",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15246;Q6IFL5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "O43749-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60403-1",
        "uniprot_id": [
            {
                "id": "O10H2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60403",
                "type": "external"
            }
        ],
        "mass": 34663.0,
        "length": 315,
        "protein_name": "Olfactory receptor 10H2",
        "gene_name": "OR10H2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10H2",
        "refseq_ac": [
            {
                "id": "NP_039227",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_039227",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10H2",
        "gene_names_refseq": "OR10H2",
        "protein_names_uniprotkb": "Olfactory receptor 10H2; Olfactory receptor OR19-23",
        "protein_names_refseq": "olfactory receptor 10H2; olfactory receptor OR19-23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26538);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 23,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;23647072;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31217245;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFQ1;Q96R58",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "O60403-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95006-1",
        "uniprot_id": [
            {
                "id": "OR2F2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95006",
                "type": "external"
            }
        ],
        "mass": 35294.0,
        "length": 317,
        "protein_name": "Olfactory receptor 2F2",
        "gene_name": "OR2F2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2F2",
        "refseq_ac": [
            {
                "id": "NP_001004685",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2F2",
        "gene_names_refseq": "OR2F2; OR7-1",
        "protein_names_uniprotkb": "Olfactory receptor 2F2; OR7-1; Olfactory receptor 7-1; Olfactory receptor OR7-6",
        "protein_names_refseq": "olfactory receptor 2F2; olfactory receptor 7-1; olfactory receptor OR7-6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:135948);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;20855565;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2G0;Q6IFP8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "O95006-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95918-1",
        "uniprot_id": [
            {
                "id": "OR2H2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95918",
                "type": "external"
            }
        ],
        "mass": 34763.0,
        "length": 312,
        "protein_name": "Olfactory receptor 2H2",
        "gene_name": "OR2H2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2H2",
        "refseq_ac": [
            {
                "id": "NP_009091",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009091",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2H2; FAT11; OLFR2; OR2H3",
        "gene_names_refseq": "FAT11; OLFR2; OLFR42B; OR2H2; OR2H3; dJ271M21.2; hs6M1-12",
        "protein_names_uniprotkb": "Olfactory receptor 2H2; Hs6M1-12; Olfactory receptor 2H3; Olfactory receptor-like protein FAT11",
        "protein_names_refseq": "Olfactory receptor 2; olfactory receptor 2H2; olfactory receptor 2H3; olfactory receptor OR6-36; olfactory receptor, family 2, subfamily H, member 3; olfactory receptor-like protein FAT11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7932);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "10880742;14983052;17971048;19833159;19851445;24800820;25892735;27515280;31974307;32066986;35051231;7665158",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15062;Q2M1Y3;Q5STL8;Q5SUK1;Q6IFN7;Q6NTB7;Q96R14",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006952 defense response;GO:0007618 mating;GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "O95918-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C629-1",
        "uniprot_id": [
            {
                "id": "O10J4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C629",
                "type": "external"
            }
        ],
        "mass": 34925.0,
        "length": 311,
        "protein_name": "Olfactory receptor 10J4",
        "gene_name": "OR10J4",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10J4",
        "refseq_ac": [
            {
                "id": "NP_001335215",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335215",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10J4; OR10J4P",
        "gene_names_refseq": "OR10J4P; OR10J4; OST717",
        "protein_names_uniprotkb": "Olfactory receptor 10J4",
        "protein_names_refseq": "olfactory receptor 10J4; olfactory receptor, family 10, subfamily J, member 4 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:391121);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "17973576;24800820;27515280;31974307;32066986;35705054",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "P0C629-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0CE71-1",
        "uniprot_id": [
            {
                "id": "OCM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0CE71",
                "type": "external"
            }
        ],
        "mass": 12129.0,
        "length": 109,
        "protein_name": "Oncomodulin-2",
        "gene_name": "OCM2",
        "organism": "Human",
        "refseq_name": "oncomodulin-2",
        "refseq_ac": [
            {
                "id": "NP_006179",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006179",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OCM2; OCMN",
        "gene_names_refseq": "OCM2; OCM; OM",
        "protein_names_uniprotkb": "Oncomodulin-2",
        "protein_names_refseq": "oncomodulin-2; parvalbumin beta; putative oncomodulin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4951)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "23832597",
        "class_list": "",
        "function": "This gene is similar to the oncomodulin gene, a high-affinity calcium ion-binding protein that belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. [provided by RefSeq, Jul 2008]., [RefSeq]; This study deministrated that Parvalbumin-immunoreactive neurons in the human claustrum., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P32930;Q6ISI5;Q75MW0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P0CE71-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30953-1",
        "uniprot_id": [
            {
                "id": "OR1E1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30953",
                "type": "external"
            }
        ],
        "mass": 35264.0,
        "length": 314,
        "protein_name": "Olfactory receptor 1E1",
        "gene_name": "OR1E1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1E1",
        "refseq_ac": [
            {
                "id": "NP_003544",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003544",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1E1; OR1E5; OR1E6; OR1E9P",
        "gene_names_refseq": "HGM071; OR13-66; OR17-2; OR17-32; OR1E1; OR1E5; OR1E6; OR1E8P; OR1E9P; OST547",
        "protein_names_uniprotkb": "Olfactory receptor 1E1; OR13-66; OR17-2; OR17-32; OR5-85; Olfactory receptor 13-66; Olfactory receptor 17-2/17-32; Olfactory receptor 1E5; Olfactory receptor 1E6; Olfactory receptor 5-85; Olfactory receptor OR17-18; Olfactory receptor-like protein HGMP07I",
        "protein_names_refseq": "OR5-85; olfactory receptor 13-66; olfactory receptor 17-2/17-32; olfactory receptor 1E1; olfactory receptor 1E5; olfactory receptor 1E6; olfactory receptor 5-85; olfactory receptor OR17-18; olfactory receptor OR17-4; olfactory receptor, family 1, subfamily E, member 5; olfactory receptor, family 1, subfamily E, member 6; olfactory receptor, family 1, subfamily E, member 8 pseudogene; olfactory receptor, family 1, subfamily E, member 9 pseudogene; olfactory receptor-like protein HGMP07I",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8387);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 25,
        "publication_id_list": "10460249;10673334;1370859;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986;8004088;9500546",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43884;P47882;P47885;Q6IFA9;Q6IFM5;Q9UBJ1;Q9UM60",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "P30953-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P34982-1",
        "uniprot_id": [
            {
                "id": "OR1D2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P34982",
                "type": "external"
            }
        ],
        "mass": 35240.0,
        "length": 312,
        "protein_name": "Olfactory receptor 1D2",
        "gene_name": "OR1D2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1D2",
        "refseq_ac": [
            {
                "id": "NP_002539",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002539",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1D2; OLFR1",
        "gene_names_refseq": "OLFR1; OR17-4; OR1D2",
        "protein_names_uniprotkb": "Olfactory receptor 1D2; OR17-4; Olfactory receptor 17-4; Olfactory receptor OR17-6; Olfactory receptor-like protein HGMP07E",
        "protein_names_refseq": "olfactory receptor 17-4; olfactory receptor 1D2; olfactory receptor OR17-6; olfactory receptor-like protein HGMP07E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4991);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 30,
        "publication_id_list": "10460249;10673334;12663925;14983052;15458659;15598656;16820410;17601748;17873857;17973576;19474308;19581598;21454689;23525651;24316890;24715725;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986;8004088;8097991",
        "class_list": "",
        "function": "Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception., [UniProtKB, PubMed, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; The homo-oligomerization status of the human OR1740 receptor and its involvement in receptor activation upon odorant ligand binding were addressed, [RefSeq, PubMed]; The present preliminary study seems to confirm the important role of OR1D2 both in nose and spermatozoa and may explain the idiopathic infertility of the study group., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFL8;Q96RA4;Q9UM78",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007338 single fertilization;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "P34982-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P47881-1",
        "uniprot_id": [
            {
                "id": "OR3A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P47881",
                "type": "external"
            }
        ],
        "mass": 34609.0,
        "length": 315,
        "protein_name": "Olfactory receptor 3A1",
        "gene_name": "OR3A1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 3A1",
        "refseq_ac": [
            {
                "id": "NP_002541",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002541",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR3A1; OLFRA03",
        "gene_names_refseq": "OLFRA03; OR17-40; OR17-82; OR3A1; OR40",
        "protein_names_uniprotkb": "Olfactory receptor 3A1; OR17-40; Olfactory receptor 17-40; Olfactory receptor OR17-15",
        "protein_names_refseq": "Olfactory receptor-like protein OR17-82; olfactory receptor 17-40; olfactory receptor 3A1; olfactory receptor OR17-15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4994);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 29,
        "publication_id_list": "10.1101/2023.09.13.557529;10460249;10673334;14983052;15598656;16980412;17579849;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31154438;31974307;32066986;8004088;8647456;8921386",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; This unique mechanism of continuous internalization and recycling of OR17-40 might be instrumental in allowing rapid recovery of odor perception., [RefSeq, PubMed]; This work shows the feasibility of an olfactory biosensor based on the immobilization of Saccharomyces cerevisiae yeast cells genetically modified to express the human olfactory receptor OR17-40, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9452,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VB06;Q6IFM4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "P47881-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P47887-1",
        "uniprot_id": [
            {
                "id": "OR1E2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P47887",
                "type": "external"
            }
        ],
        "mass": 36391.0,
        "length": 323,
        "protein_name": "Olfactory receptor 1E2",
        "gene_name": "OR1E2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1E2",
        "refseq_ac": [
            {
                "id": "NP_003545",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003545",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1E2; OR1E4",
        "gene_names_refseq": "OR17-135; OR17-136; OR17-93; OR1E2; OR1E4; OR1E7; OST529",
        "protein_names_uniprotkb": "Olfactory receptor 1E2; OR17-135; OR17-136; OR17-93; Olfactory receptor 17-93/17-135/17-136; Olfactory receptor 1E4",
        "protein_names_refseq": "olfactory receptor 17-93/17-135/17-136; olfactory receptor 1E2; olfactory receptor 1E4; olfactory receptor OR17-17; olfactory receptor OR17-3; olfactory receptor, family 1, subfamily E, member 4; olfactory receptor, family 1, subfamily E, member 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8388);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 10,
        "publication_id_list": "10673334;16959974;24715725;24800820;27515280;31974307;32066986;35051231;8004088;9500546",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43877;O95632;Q0VAD5;Q0VAD6;Q9UL13",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007606 sensory perception of chemical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "P47887-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P58170-1",
        "uniprot_id": [
            {
                "id": "OR1D5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P58170",
                "type": "external"
            }
        ],
        "mass": 35424.0,
        "length": 312,
        "protein_name": "Olfactory receptor 1D5",
        "gene_name": "OR1D5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1D5",
        "refseq_ac": [
            {
                "id": "NP_055381",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055381",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1D5",
        "gene_names_refseq": "C17orf2; OR17-2; OR17-31; OR1D5",
        "protein_names_uniprotkb": "Olfactory receptor 1D5; OR17-31; Olfactory receptor 17-31",
        "protein_names_refseq": "olfactory receptor 17-31; olfactory receptor 1D5; olfactory receptor OR17-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8386);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "10460249;10673334;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986;33141586",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUK4;Q96RA6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "P58170-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P58173-1",
        "uniprot_id": [
            {
                "id": "OR2B6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P58173",
                "type": "external"
            }
        ],
        "mass": 35414.0,
        "length": 313,
        "protein_name": "Olfactory receptor 2B6",
        "gene_name": "OR2B6",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2B6",
        "refseq_ac": [
            {
                "id": "NP_036499",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036499",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2B6; OR2B1P; OR2B1; OR2B5; OR2B6P",
        "gene_names_refseq": "OR2B1P; OR2B1; OR2B5; OR2B6P; OR2B6; OR5-40; OR5-41; OR6-31; dJ408B20.2",
        "protein_names_uniprotkb": "Olfactory receptor 2B6; Hs6M1-32; OR5-40; OR6-31; Olfactory receptor 2B1; Olfactory receptor 2B5; Olfactory receptor 5-40; Olfactory receptor 6-31; Olfactory receptor OR6-4",
        "protein_names_refseq": "hs6M1-32; olfactory receptor 2B1; olfactory receptor 2B5; olfactory receptor 2B6; olfactory receptor 5-40; olfactory receptor 6-31; olfactory receptor OR6-4; olfactory receptor, family 2, subfamily B, member 1 pseudogene; olfactory receptor, family 2, subfamily B, member 5; olfactory receptor, family 2, subfamily B, member 6 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26212);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;33592498;35051231;35494241;9500546",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A126GW55;O43883;Q6IF89;Q9H5B0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P58173-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13607-1",
        "uniprot_id": [
            {
                "id": "OR2F1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13607",
                "type": "external"
            }
        ],
        "mass": 35350.0,
        "length": 317,
        "protein_name": "Olfactory receptor 2F1",
        "gene_name": "OR2F1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2F1",
        "refseq_ac": [
            {
                "id": "NP_036501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2F1; OLF3; OR2F3P; OR2F3; OR2F4; OR2F5",
        "gene_names_refseq": "7M1-2; OLF3; OR14-60; OR2F1; OR2F3P; OR2F3; OR2F4; OR2F5; OR7-139; OR7-140",
        "protein_names_uniprotkb": "Olfactory receptor 2F1; Olfactory receptor 2F3; Olfactory receptor 2F4; Olfactory receptor 2F5; Olfactory receptor-like protein OLF3",
        "protein_names_refseq": "olfactory receptor 2F1; olfactory receptor 2F3; olfactory receptor 2F4; olfactory receptor 2F5; olfactory receptor OR7-7; olfactory receptor, family 2, subfamily F, member 3; olfactory receptor, family 2, subfamily F, member 4; olfactory receptor, family 2, subfamily F, member 5; olfactory receptor-like protein OLF3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26211);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 24,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;29557506;31040214;31844290;31974307;32066986;9017400",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2G1;Q6IFP7;Q96R49;Q9UDX1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q13607-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3SX64-1",
        "uniprot_id": [
            {
                "id": "CMA1D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3SX64",
                "type": "external"
            }
        ],
        "mass": 30781.0,
        "length": 289,
        "protein_name": "Protein CIMAP1D",
        "gene_name": "CIMAP1D",
        "organism": "Human",
        "refseq_name": "protein CIMAP1D isoform a",
        "refseq_ac": [
            {
                "id": "NP_872383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CIMAP1D; C19orf19; ODF3L2",
        "gene_names_refseq": "C19orf19; CIMAP1D; ODF3L2",
        "protein_names_uniprotkb": "Protein CIMAP1D; CIMAP1 family member D; Outer dense fiber protein 3-like protein 2",
        "protein_names_refseq": "outer dense fiber of sperm tails 3 like 2; outer dense fiber protein 3-like protein 2; protein CIMAP1D isoform a; protein CIMAP1D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284451)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "18083107;20068231;24715725;29485866;30379171",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3SX65;Q8N1L2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005881 cytoplasmic microtubule",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q3SX64-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IEV9-1",
        "uniprot_id": [
            {
                "id": "OR4CB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IEV9",
                "type": "external"
            }
        ],
        "mass": 35003.0,
        "length": 310,
        "protein_name": "Olfactory receptor 4C11",
        "gene_name": "OR4C11",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4C11",
        "refseq_ac": [
            {
                "id": "NP_001004700",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004700",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4C11; OR4C11P",
        "gene_names_refseq": "OR11-136; OR4C11P; OR4C11",
        "protein_names_uniprotkb": "Olfactory receptor 4C11; Olfactory receptor OR11-136",
        "protein_names_refseq": "olfactory receptor 4C11; olfactory receptor OR11-136; olfactory receptor, family 4, subfamily C, member 11 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219429);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;29296522;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIL4;Q8NGL8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6IEV9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N0Y3-1",
        "uniprot_id": [
            {
                "id": "OR4N4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N0Y3",
                "type": "external"
            }
        ],
        "mass": 35724.0,
        "length": 316,
        "protein_name": "Olfactory receptor 4N4",
        "gene_name": "OR4N4",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4N4",
        "refseq_ac": [
            {
                "id": "NP_001005241",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005241",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4N4",
        "gene_names_refseq": "OR15-1; OR15-5; OR4N4",
        "protein_names_uniprotkb": "Olfactory receptor 4N4; Olfactory receptor OR15-1; Olfactory receptor OR15-5",
        "protein_names_refseq": "olfactory receptor 4N4; olfactory receptor OR15-1; olfactory receptor OR15-5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283694);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;32938616;33141586;35051231;35494241",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEY3;Q6IF56",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8N0Y3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NG94-1",
        "uniprot_id": [
            {
                "id": "O11H1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NG94",
                "type": "external"
            }
        ],
        "mass": 36578.0,
        "length": 326,
        "protein_name": "Olfactory receptor 11H1",
        "gene_name": "OR11H1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 11H1",
        "refseq_ac": [
            {
                "id": "NP_001005239",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005239",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR11H1",
        "gene_names_refseq": "OR11H1; OR22-1",
        "protein_names_uniprotkb": "Olfactory receptor 11H1; Olfactory receptor OR22-1",
        "protein_names_refseq": "olfactory receptor 11H1; olfactory receptor OR22-1; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81061);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "11237011;14983052;18477386;24800820;27515280;31154438;31974307;32066986;38168905",
        "class_list": "",
        "function": "OR11H1 Missense Variant Confers the Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45g Expression., [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEX0;Q96R32",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NG94-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGA1-1",
        "uniprot_id": [
            {
                "id": "OR1M1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGA1",
                "type": "external"
            }
        ],
        "mass": 34840.0,
        "length": 313,
        "protein_name": "Olfactory receptor 1M1",
        "gene_name": "OR1M1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1M1",
        "refseq_ac": [
            {
                "id": "NP_001004456",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004456",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1M1",
        "gene_names_refseq": "OR19-5; OR19-6; OR1M1",
        "protein_names_uniprotkb": "Olfactory receptor 1M1; OR19-6; Olfactory receptor 19-6; Olfactory receptor OR19-5",
        "protein_names_refseq": "olfactory receptor 19-6; olfactory receptor 1M1; olfactory receptor OR19-5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:125963);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;28510447;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EHA6;Q6IFJ3;Q96R91",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGA1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGB2-1",
        "uniprot_id": [
            {
                "id": "OR4C5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGB2",
                "type": "external"
            }
        ],
        "mass": 36862.0,
        "length": 326,
        "protein_name": "Olfactory receptor 4C5",
        "gene_name": "OR4C5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4C5",
        "refseq_ac": [
            {
                "id": "NP_001335152",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335152",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4C5",
        "gene_names_refseq": "OR4C5P; OR4C5Q; OR4C5",
        "protein_names_uniprotkb": "Olfactory receptor 4C5; Olfactory receptor OR11-99",
        "protein_names_refseq": "olfactory receptor 4C5; olfactory receptor OR11-99; olfactory receptor, family 4, subfamily C, member 5 pseudogene; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79346);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;23481700;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFB2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGB2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGC7-1",
        "uniprot_id": [
            {
                "id": "O11H6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGC7",
                "type": "external"
            }
        ],
        "mass": 36788.0,
        "length": 330,
        "protein_name": "Olfactory receptor 11H6",
        "gene_name": "OR11H6",
        "organism": "Human",
        "refseq_name": "olfactory receptor 11H6",
        "refseq_ac": [
            {
                "id": "NP_001004480",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004480",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR11H6",
        "gene_names_refseq": "OR11H6",
        "protein_names_uniprotkb": "Olfactory receptor 11H6; Olfactory receptor OR14-35",
        "protein_names_refseq": "olfactory receptor 11H6; olfactory receptor OR14-35",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122748);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 21,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF08",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8NGC7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGD0-1",
        "uniprot_id": [
            {
                "id": "OR4M1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGD0",
                "type": "external"
            }
        ],
        "mass": 35488.0,
        "length": 313,
        "protein_name": "Olfactory receptor 4M1",
        "gene_name": "OR4M1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4M1",
        "refseq_ac": [
            {
                "id": "NP_001005500",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005500",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4M1",
        "gene_names_refseq": "OLFR734; OR14-7; OR4M1",
        "protein_names_uniprotkb": "Olfactory receptor 4M1; Olfactory receptor OR14-7",
        "protein_names_refseq": "olfactory receptor 4M1; olfactory receptor OR14-7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441670);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;24800820;27515280;31230984;31974307;32066986;35707591",
        "class_list": "",
        "function": "Asprosin is a key regulatory factor for preserving the homeostasis of energy metabolism. Asprosin promotes hepatic glucose release in the liver and appetite stimulation in the hypothalamus through activation of the cAMP signaling circuitry through interacting with its G protein-coupled receptor, called OR4M1. In this review, we discuss the current literature on asprosin and its receptor, OR4M1. Review article, [RefSeq, PubMed]; Olfactory receptor that acts as a receptor of Asprosin hormone, potentially at the surface of hepatocytes and may help to promote hepatocyte glucose release., [UniProtKB, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EH18;Q6IFA3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGD0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGE3-1",
        "uniprot_id": [
            {
                "id": "O10P1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGE3",
                "type": "external"
            }
        ],
        "mass": 34741.0,
        "length": 313,
        "protein_name": "Olfactory receptor 10P1",
        "gene_name": "OR10P1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10P1",
        "refseq_ac": [
            {
                "id": "NP_996782",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996782",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10P1; OR10P1P; OR10P2P; OR10P3P",
        "gene_names_refseq": "OR10P1P; OR10P1; OR10P2P; OR10P3P; OR12-7; OST701",
        "protein_names_uniprotkb": "Olfactory receptor 10P1; Olfactory receptor 10P2; Olfactory receptor 10P3; Olfactory receptor OR12-7",
        "protein_names_refseq": "olfactory receptor 10P1; olfactory receptor 10P2; olfactory receptor 10P3; olfactory receptor OR12-7; olfactory receptor, family 10, subfamily P, member 1 pseudogene; olfactory receptor, family 10, subfamily P, member 2 pseudogene; olfactory receptor, family 10, subfamily P, member 3 pseudogene; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:121130);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;24800820;27515280;29557506;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGY4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGE3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGE5-1",
        "uniprot_id": [
            {
                "id": "O10A7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGE5",
                "type": "external"
            }
        ],
        "mass": 35695.0,
        "length": 316,
        "protein_name": "Olfactory receptor 10A7",
        "gene_name": "OR10A7",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10A7",
        "refseq_ac": [
            {
                "id": "NP_001005280",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005280",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10A7",
        "gene_names_refseq": "OR10A7; OR12-6",
        "protein_names_uniprotkb": "Olfactory receptor 10A7; Olfactory receptor OR12-6",
        "protein_names_refseq": "olfactory receptor 10A7; olfactory receptor OR12-6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:121364);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "10.1101/2023.09.13.557529;14983052;24800820;27515280;31974307;32066986;32938616",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFD5;Q96R19",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NGE5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGF7-1",
        "uniprot_id": [
            {
                "id": "OR5BH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGF7",
                "type": "external"
            }
        ],
        "mass": 35091.0,
        "length": 314,
        "protein_name": "Olfactory receptor 5B17",
        "gene_name": "OR5B17",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5B17",
        "refseq_ac": [
            {
                "id": "NP_001005489",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005489",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5B17; OR5B20P",
        "gene_names_refseq": "OR11-237; OR5B17; OR5B20P",
        "protein_names_uniprotkb": "Olfactory receptor 5B17; Olfactory receptor 5B20; Olfactory receptor OR11-237",
        "protein_names_refseq": "olfactory receptor 5B17; olfactory receptor 5B20; olfactory receptor OR11-237; olfactory receptor, family 5, subfamily B, member 20 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219965);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;29393594;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEX1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NGF7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGF9-1",
        "uniprot_id": [
            {
                "id": "OR4X2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGF9",
                "type": "external"
            }
        ],
        "mass": 34289.0,
        "length": 303,
        "protein_name": "Olfactory receptor 4X2",
        "gene_name": "OR4X2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4X2",
        "refseq_ac": [
            {
                "id": "NP_001004727",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004727",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4X2",
        "gene_names_refseq": "OR11-105; OR4X2",
        "protein_names_uniprotkb": "Olfactory receptor 4X2; Olfactory receptor OR11-105",
        "protein_names_refseq": "olfactory receptor 4X2; olfactory receptor OR11-105",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:119764);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 10,
        "publication_id_list": "14983052;17973576;23481700;24715725;24800820;27515280;28904123;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNK3;Q6IF73;Q96R63",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8NGF9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG4-1",
        "uniprot_id": [
            {
                "id": "OR8H1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG4",
                "type": "external"
            }
        ],
        "mass": 35228.0,
        "length": 311,
        "protein_name": "Olfactory receptor 8H1",
        "gene_name": "OR8H1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8H1",
        "refseq_ac": [
            {
                "id": "NP_001005199",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005199",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8H1",
        "gene_names_refseq": "OR11-180; OR8H1",
        "protein_names_uniprotkb": "Olfactory receptor 8H1; Olfactory receptor OR11-180",
        "protein_names_refseq": "olfactory receptor 8H1; olfactory receptor OR11-180",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219469);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNI7;Q6IFC5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NGG4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG5-1",
        "uniprot_id": [
            {
                "id": "OR8K1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG5",
                "type": "external"
            }
        ],
        "mass": 36581.0,
        "length": 319,
        "protein_name": "Olfactory receptor 8K1",
        "gene_name": "OR8K1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8K1",
        "refseq_ac": [
            {
                "id": "NP_001002907",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002907",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8K1",
        "gene_names_refseq": "OR11-182; OR8K1; OR8N1P",
        "protein_names_uniprotkb": "Olfactory receptor 8K1; Olfactory receptor OR11-182",
        "protein_names_refseq": "olfactory receptor 8K1; olfactory receptor OR11-182; olfactory receptor, family 8, subfamily N, member 1 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390157);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EJB1;Q6IFC3;Q96RC1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NGG5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGL2-1",
        "uniprot_id": [
            {
                "id": "OR5L1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGL2",
                "type": "external"
            }
        ],
        "mass": 34559.0,
        "length": 311,
        "protein_name": "Olfactory receptor 5L1",
        "gene_name": "OR5L1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5L1",
        "refseq_ac": [
            {
                "id": "NP_001004738",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004738",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5L1",
        "gene_names_refseq": "OR11-151; OR5L1; OST262",
        "protein_names_uniprotkb": "Olfactory receptor 5L1; OST262; Olfactory receptor OR11-151",
        "protein_names_refseq": "olfactory receptor 5L1; olfactory receptor OR11-151",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219437);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;32157095;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNK6;Q6IFD0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGL2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGP0-1",
        "uniprot_id": [
            {
                "id": "OR4CD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGP0",
                "type": "external"
            }
        ],
        "mass": 34582.0,
        "length": 309,
        "protein_name": "Olfactory receptor 4C13",
        "gene_name": "OR4C13",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4C13",
        "refseq_ac": [
            {
                "id": "NP_001001955",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001955",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4C13",
        "gene_names_refseq": "OR4C13",
        "protein_names_uniprotkb": "Olfactory receptor 4C13; Olfactory receptor OR11-260",
        "protein_names_refseq": "olfactory receptor 4C13; olfactory receptor OR11-260",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283092);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "14983052;24800820;26768311;27515280;31844290;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJJ3;B9EH30;Q6IF48;Q96R68",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGP0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGP6-1",
        "uniprot_id": [
            {
                "id": "OR5M8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGP6",
                "type": "external"
            }
        ],
        "mass": 35603.0,
        "length": 311,
        "protein_name": "Olfactory receptor 5M8",
        "gene_name": "OR5M8",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5M8",
        "refseq_ac": [
            {
                "id": "NP_001005282",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005282",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5M8",
        "gene_names_refseq": "OR11-194; OR5M8",
        "protein_names_uniprotkb": "Olfactory receptor 5M8; Olfactory receptor OR11-194",
        "protein_names_refseq": "olfactory receptor 5M8; olfactory receptor OR11-194",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219484);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "14983052;24800820;27515280;27862975;30418433;31844290;31848261;31974307;32066986;35051231;36215666",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNM5;Q6IEW3;Q96RB8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8NGP6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGR3-1",
        "uniprot_id": [
            {
                "id": "OR1K1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGR3",
                "type": "external"
            }
        ],
        "mass": 34268.0,
        "length": 316,
        "protein_name": "Olfactory receptor 1K1",
        "gene_name": "OR1K1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1K1",
        "refseq_ac": [
            {
                "id": "NP_543135",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543135",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1K1",
        "gene_names_refseq": "OR1K1; hg99",
        "protein_names_uniprotkb": "Olfactory receptor 1K1",
        "protein_names_refseq": "olfactory receptor 1K1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:392392);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 14,
        "publication_id_list": "20583170;24800820;27515280;31530632;31844290;31974307;32066986;32387766;33592498;33802009;34171305;35051231;35580925;39894887",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; UV-Irradiation- and Inflammation-Induced Skin Barrier Dysfunction Is Associated with the Expression of Olfactory Receptor Genes in Human Keratinocytes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EH41;Q4VXB7;Q96R23",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q8NGR3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGR9-1",
        "uniprot_id": [
            {
                "id": "OR1N2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGR9",
                "type": "external"
            }
        ],
        "mass": 35184.0,
        "length": 316,
        "protein_name": "Olfactory receptor 1N2",
        "gene_name": "OR1N2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1N2",
        "refseq_ac": [
            {
                "id": "NP_001004457",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004457",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1N2",
        "gene_names_refseq": "OR1N2; OR9-23",
        "protein_names_uniprotkb": "Olfactory receptor 1N2; Olfactory receptor OR9-23",
        "protein_names_refseq": "olfactory receptor 1N2; olfactory receptor OR9-23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:138882);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;20583170;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A126GW94;A3KFM2;B2RNY4;Q6IF17;Q96RA3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q8NGR9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGT9-1",
        "uniprot_id": [
            {
                "id": "OR2A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGT9",
                "type": "external"
            }
        ],
        "mass": 34714.0,
        "length": 310,
        "protein_name": "Olfactory receptor 2A1/2A42",
        "gene_name": "OR2A1; OR2A42",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2A1/2A42",
        "refseq_ac": [
            {
                "id": "NP_001001802",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001802",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2A1; OR2A42",
        "gene_names_refseq": "OR2A42",
        "protein_names_uniprotkb": "Olfactory receptor 2A1/2A42; Olfactory receptor OR7-16; Olfactory receptor OR7-19",
        "protein_names_refseq": "olfactory receptor 2A1/2A42; olfactory receptor OR7-16; olfactory receptor OR7-19; olfactory receptor, family 2, subfamily A, member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:346528);  (hsa:402317);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 4,
        "publication_count": 21,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF44;Q96R46",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8NGT9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGX3-1",
        "uniprot_id": [
            {
                "id": "O10T2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGX3",
                "type": "external"
            }
        ],
        "mass": 35011.0,
        "length": 314,
        "protein_name": "Olfactory receptor 10T2",
        "gene_name": "OR10T2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10T2",
        "refseq_ac": [
            {
                "id": "NP_001004475",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004475",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10T2",
        "gene_names_refseq": "OR1-3; OR10T2",
        "protein_names_uniprotkb": "Olfactory receptor 10T2; Olfactory receptor OR1-3",
        "protein_names_refseq": "olfactory receptor 10T2; olfactory receptor OR1-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128360);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "14983052;20677014;24800820;27515280;31092671;31974307;32066986;35051231",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF98",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGX3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGX5-1",
        "uniprot_id": [
            {
                "id": "O10K1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGX5",
                "type": "external"
            }
        ],
        "mass": 35079.0,
        "length": 313,
        "protein_name": "Olfactory receptor 10K1",
        "gene_name": "OR10K1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10K1",
        "refseq_ac": [
            {
                "id": "NP_001004473",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004473",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10K1",
        "gene_names_refseq": "OR1-6; OR10K1",
        "protein_names_uniprotkb": "Olfactory receptor 10K1; Olfactory receptor OR1-6",
        "protein_names_refseq": "olfactory receptor 10K1; olfactory receptor OR1-6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:391109);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "14983052;20677014;24800820;26992070;27515280;28411811;31974307;32066986;35051231",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFS2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8NGX5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGY0-1",
        "uniprot_id": [
            {
                "id": "O10X1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGY0",
                "type": "external"
            }
        ],
        "mass": 36446.0,
        "length": 326,
        "protein_name": "Olfactory receptor 10X1",
        "gene_name": "OR10X1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10X1",
        "refseq_ac": [
            {
                "id": "NP_001004477",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004477",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10X1; OR10X1P",
        "gene_names_refseq": "OR1-13; OR1-14; OR10X1P; OR10X1",
        "protein_names_uniprotkb": "Olfactory receptor 10X1; Olfactory receptor OR1-14",
        "protein_names_refseq": "olfactory receptor 10X1; olfactory receptor OR1-13 pseudogene; olfactory receptor OR1-14; olfactory receptor, family 10, subfamily X, member 1 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128367);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 25,
        "publication_id_list": "10460249;12730696;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;29557506;31040214;31974307;32066986;33141586;33392160",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFR8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q8NGY0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGY1-1",
        "uniprot_id": [
            {
                "id": "O10Z1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGY1",
                "type": "external"
            }
        ],
        "mass": 34609.0,
        "length": 313,
        "protein_name": "Olfactory receptor 10Z1",
        "gene_name": "OR10Z1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10Z1",
        "refseq_ac": [
            {
                "id": "NP_001004478",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004478",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10Z1",
        "gene_names_refseq": "OR1-15; OR10Z1",
        "protein_names_uniprotkb": "Olfactory receptor 10Z1; Olfactory receptor OR1-15",
        "protein_names_refseq": "olfactory receptor 10Z1; olfactory receptor OR1-15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128368);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "14983052;20677014;24800820;27515280;31844290;31974307;32066986;32938616;35051231",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VYL0;Q6IFR7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NGY1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGY2-1",
        "uniprot_id": [
            {
                "id": "OR6K2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGY2",
                "type": "external"
            }
        ],
        "mass": 36513.0,
        "length": 324,
        "protein_name": "Olfactory receptor 6K2",
        "gene_name": "OR6K2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6K2",
        "refseq_ac": [
            {
                "id": "NP_001005279",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005279",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6K2",
        "gene_names_refseq": "OR1-17; OR6K2",
        "protein_names_uniprotkb": "Olfactory receptor 6K2; Olfactory receptor OR1-17",
        "protein_names_refseq": "olfactory receptor 6K2; olfactory receptor OR1-17",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81448);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "14983052;24800820;25576301;27515280;31974307;32066986;32488085;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EH33;Q6IFR6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGY2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGY7-1",
        "uniprot_id": [
            {
                "id": "O10J6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGY7",
                "type": "external"
            }
        ],
        "mass": 31021.0,
        "length": 276,
        "protein_name": "Putative olfactory receptor 10J6",
        "gene_name": "OR10J6P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR10J6P; OR10J6",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative olfactory receptor 10J6",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "31154438;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96R55",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q8NGY7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH21-1",
        "uniprot_id": [
            {
                "id": "OR4F5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH21",
                "type": "external"
            }
        ],
        "mass": 34330.0,
        "length": 305,
        "protein_name": "Olfactory receptor 4F5",
        "gene_name": "OR4F5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4F5",
        "refseq_ac": [
            {
                "id": "NP_001005484",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005484",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4F5",
        "gene_names_refseq": "OR4F5",
        "protein_names_uniprotkb": "Olfactory receptor 4F5",
        "protein_names_refseq": "olfactory receptor 4F5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79501);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "11237011;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VT22",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NH21-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH43-1",
        "uniprot_id": [
            {
                "id": "OR4L1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH43",
                "type": "external"
            }
        ],
        "mass": 35264.0,
        "length": 312,
        "protein_name": "Olfactory receptor 4L1",
        "gene_name": "OR4L1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4L1",
        "refseq_ac": [
            {
                "id": "NP_001004717",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004717",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4L1; OR4L2P",
        "gene_names_refseq": "OR14-28; OR4L1; OR4L2P",
        "protein_names_uniprotkb": "Olfactory receptor 4L1; Olfactory receptor 4L2; Olfactory receptor OR14-28",
        "protein_names_refseq": "olfactory receptor 4L1; olfactory receptor 4L2; olfactory receptor OR14-28; olfactory receptor, family 4, subfamily L, member 2 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122742);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 23,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;23481700;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31844290;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEZ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8NH43-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH50-1",
        "uniprot_id": [
            {
                "id": "OR8K5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH50",
                "type": "external"
            }
        ],
        "mass": 35190.0,
        "length": 307,
        "protein_name": "Olfactory receptor 8K5",
        "gene_name": "OR8K5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8K5",
        "refseq_ac": [
            {
                "id": "NP_001004058",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004058",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8K5",
        "gene_names_refseq": "OR11-174; OR8K5",
        "protein_names_uniprotkb": "Olfactory receptor 8K5; Olfactory receptor OR11-174",
        "protein_names_refseq": "olfactory receptor 8K5; olfactory receptor OR11-174",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219453);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFB5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NH50-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH73-1",
        "uniprot_id": [
            {
                "id": "OR4S2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH73",
                "type": "external"
            }
        ],
        "mass": 35172.0,
        "length": 311,
        "protein_name": "Olfactory receptor 4S2",
        "gene_name": "OR4S2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4S2",
        "refseq_ac": [
            {
                "id": "NP_001004059",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004059",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4S2; OR4S2P",
        "gene_names_refseq": "OR11-137; OR4S2P; OR4S2; OST725",
        "protein_names_uniprotkb": "Olfactory receptor 4S2; Olfactory receptor OR11-137",
        "protein_names_refseq": "olfactory receptor 4S2; olfactory receptor OR11-137; olfactory receptor, family 4, subfamily S, member 2 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219431);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;17924679;24800820;27515280;31974307;32066986;32387766",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF72",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NH73-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH80-1",
        "uniprot_id": [
            {
                "id": "O10D3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH80",
                "type": "external"
            }
        ],
        "mass": 34812.0,
        "length": 312,
        "protein_name": "Olfactory receptor 10D3",
        "gene_name": "OR10D3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10D3",
        "refseq_ac": [
            {
                "id": "NP_001342142",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001342142",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10D3; OR10D3P",
        "gene_names_refseq": "HTPCRX09; OR10D3P; OR10D3",
        "protein_names_uniprotkb": "Olfactory receptor 10D3; HTPCRX09; Olfactory receptor OR11-293",
        "protein_names_refseq": "olfactory receptor 10D3; olfactory receptor OR11-293; olfactory receptor family 10 subfamily D member 3 (putative); olfactory receptor, family 10, subfamily D, member 3 (non-functional); olfactory receptor, family 10, subfamily D, member 3 pseudogene; putative olfactory receptor 10D3; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26497);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "1370859;14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NH80-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHB1-1",
        "uniprot_id": [
            {
                "id": "OR2V1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHB1",
                "type": "external"
            }
        ],
        "mass": 34857.0,
        "length": 315,
        "protein_name": "Olfactory receptor 2V1",
        "gene_name": "OR2V1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2V1",
        "refseq_ac": [
            {
                "id": "NP_001245212",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245212",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2V1",
        "gene_names_refseq": "OR2V1P; OR2V1; OST265",
        "protein_names_uniprotkb": "Olfactory receptor 2V1",
        "protein_names_refseq": "olfactory receptor 2V1; olfactory receptor, family 2, subfamily V, member 1 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26693);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "11237011;20112406;24800820;25892735;27515280;29557506;31217245;31844290;31974307;32066986;34932366",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8NHB1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHB8-1",
        "uniprot_id": [
            {
                "id": "OR5K2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHB8",
                "type": "external"
            }
        ],
        "mass": 35763.0,
        "length": 316,
        "protein_name": "Olfactory receptor 5K2",
        "gene_name": "OR5K2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5K2",
        "refseq_ac": [
            {
                "id": "NP_001004737",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004737",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5K2",
        "gene_names_refseq": "OR3-9; OR5K2",
        "protein_names_uniprotkb": "Olfactory receptor 5K2; Olfactory receptor OR3-9",
        "protein_names_refseq": "olfactory receptor 5K2; olfactory receptor OR3-9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:402135);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RN70;Q6IF47",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NHB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WZ92-1",
        "uniprot_id": [
            {
                "id": "OR5P2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WZ92",
                "type": "external"
            }
        ],
        "mass": 35786.0,
        "length": 322,
        "protein_name": "Olfactory receptor 5P2",
        "gene_name": "OR5P2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5P2",
        "refseq_ac": [
            {
                "id": "NP_703145",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703145",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5P2",
        "gene_names_refseq": "JCG3; JCG4; OR5P2",
        "protein_names_uniprotkb": "Olfactory receptor 5P2; Olfactory receptor-like protein JCG3",
        "protein_names_refseq": "olfactory receptor 5P2; olfactory receptor OR11-93; olfactory receptor-like protein JCG3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:120065);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "11705801;24800820;25576336;26992070;27515280;29731959;31974307;32066986;32387766",
        "class_list": "",
        "function": "Odorant receptor (Potential). May be involved in taste perception., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MIS8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8WZ92-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WZA6-1",
        "uniprot_id": [
            {
                "id": "OR1E3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WZA6",
                "type": "external"
            }
        ],
        "mass": 38518.0,
        "length": 343,
        "protein_name": "Olfactory receptor 1E3",
        "gene_name": "OR1E3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR1E3; OR1E3P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 1E3; OR17-210; Olfactory receptor 17-210; Olfactory receptor OR17-7",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "10673334;12730696;14983052;24800820;27515280;31974307;32066986;35051231;8004088",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0038022 G protein-coupled olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8WZA6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96R48-1",
        "uniprot_id": [
            {
                "id": "OR2A5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96R48",
                "type": "external"
            }
        ],
        "mass": 35207.0,
        "length": 311,
        "protein_name": "Olfactory receptor 2A5",
        "gene_name": "OR2A5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2A5",
        "refseq_ac": [
            {
                "id": "NP_036497",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036497",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2A5; OR2A26; OR2A8",
        "gene_names_refseq": "OR2A11P; OR2A26; OR2A5; OR2A8; OR7-138; OR7-141",
        "protein_names_uniprotkb": "Olfactory receptor 2A5; OR7-138; OR7-141; Olfactory receptor 2A26; Olfactory receptor 2A8; Olfactory receptor 7-138/7-141",
        "protein_names_refseq": "olfactory receptor 2A26; olfactory receptor 2A5; olfactory receptor 2A8; olfactory receptor 7-138/7-141; olfactory receptor, family 2, subfamily A, member 11 pseudogene; olfactory receptor, family 2, subfamily A, member 26; olfactory receptor, family 2, subfamily A, member 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:393046);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "24800820;27515280;31974307;32066986;33392160;9500546",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGX2;O43885;O43888",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96R48-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96R67-1",
        "uniprot_id": [
            {
                "id": "OR4CC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96R67",
                "type": "external"
            }
        ],
        "mass": 34491.0,
        "length": 309,
        "protein_name": "Olfactory receptor 4C12",
        "gene_name": "OR4C12",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4C12",
        "refseq_ac": [
            {
                "id": "NP_001005270",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005270",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4C12",
        "gene_names_refseq": "OR11-259; OR4C12",
        "protein_names_uniprotkb": "Olfactory receptor 4C12; Olfactory receptor OR11-259",
        "protein_names_refseq": "olfactory receptor 4C12; olfactory receptor OR11-259; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283093);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986;35051231",
        "class_list": "",
        "function": "Acts as a receptor for R-(-)-carvone in pancreatic cells, initiating signaling pathways involving GNAS, elevated intracellular Ca(2+), and increased cAMP levels. Upon activation, promotes glucose-stimulated insulin secretion., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNF0;Q6IF49",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0042593 glucose homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q96R67-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RA2-1",
        "uniprot_id": [
            {
                "id": "OR7D2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RA2",
                "type": "external"
            }
        ],
        "mass": 34747.0,
        "length": 312,
        "protein_name": "Olfactory receptor 7D2",
        "gene_name": "OR7D2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 7D2",
        "refseq_ac": [
            {
                "id": "NP_787079",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787079",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR7D2",
        "gene_names_refseq": "HTPCRH03; OR19-10; OR19-4; OR7D2",
        "protein_names_uniprotkb": "Olfactory receptor 7D2; HTPCRH03; OR19-4; Olfactory receptor 19-4; Olfactory receptor OR19-10",
        "protein_names_refseq": "olfactory receptor 19-4; olfactory receptor 7D2; olfactory receptor OR19-10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:162998);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFJ7;Q8N133",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96RA2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9GZU5-1",
        "uniprot_id": [
            {
                "id": "NYX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9GZU5",
                "type": "external"
            }
        ],
        "mass": 51470.0,
        "length": 476,
        "protein_name": "Nyctalopin",
        "gene_name": "NYX",
        "organism": "Human",
        "refseq_name": "nyctalopin precursor",
        "refseq_ac": [
            {
                "id": "NP_001365406",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365406",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NYX; CLRP",
        "gene_names_refseq": "CLRP; CSNB1A; CSNB1; CSNB4; NBM1; NYX",
        "protein_names_uniprotkb": "Nyctalopin",
        "protein_names_refseq": "leucine-rich repeat protein; nyctalopin precursor",
        "tax_id": 9606,
        "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); congenital stationary night blindness 1A (Disease Ontology:DOID:0110870); night blindness (Disease Ontology:DOID:8499)",
        "pathway": " (hsa:60506)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11062471;11062472;16670814;29393594;29605689;31826698;33769208;34165036",
        "class_list": "glycogene",
        "function": "Complete congenital stationary night blindness associated with a novel NYX variant (p.Asn216Lys) in middle-aged and older adult patients., [RefSeq, PubMed]; Frameshift mutation in NYX gene is associated with congenital stationary night blindness., [RefSeq, PubMed]; NYX-related Congenital Stationary Night Blindness in Two Siblings due to Probable Maternal Germline Mosaicism., [RefSeq, PubMed]; Required for normal vision. Is a critical factor for light-induced depolarization of retinal ON-bipolar cells, likely acting as a scaffold for TRPM1 and GRM6. Required for TRPM1 trafficking to dendritic tips of ON-bipolar cells., [UniProtKB, UniProtKB]; The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 568,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWC0;Q2M1S4;Q5H983;Q9H4J0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0030425 dendrite;GO:0031012 extracellular matrix;GO:0098794 postsynapse;GO:0140150 gel phase of interstitial matrix",
        "go_biological_process": "GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9GZU5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H208-1",
        "uniprot_id": [
            {
                "id": "O10A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H208",
                "type": "external"
            }
        ],
        "mass": 33817.0,
        "length": 303,
        "protein_name": "Olfactory receptor 10A2",
        "gene_name": "OR10A2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 10A2",
        "refseq_ac": [
            {
                "id": "NP_001004460",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004460",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR10A2; OR10A2P",
        "gene_names_refseq": "OR10A2P; OR10A2; OR11-82; OR11-86; OST363",
        "protein_names_uniprotkb": "Olfactory receptor 10A2; HP4; Olfactory receptor OR11-86",
        "protein_names_refseq": "hP4 olfactory receptor; olfactory receptor 10A2; olfactory receptor OR11-82 pseudogene; olfactory receptor OR11-86; olfactory receptor, family 10, subfamily A, member 2 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:341276);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "11416212;14983052;18446592;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNL9;Q6IFG9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q9H208-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2P1-1",
        "uniprot_id": [
            {
                "id": "NYNRI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2P1",
                "type": "external"
            }
        ],
        "mass": 208366.0,
        "length": 1898,
        "protein_name": "Protein NYNRIN",
        "gene_name": "NYNRIN",
        "organism": "Human",
        "refseq_name": "protein NYNRIN",
        "refseq_ac": [
            {
                "id": "NP_079357",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079357",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NYNRIN; CGIN1; KIAA1305",
        "gene_names_refseq": "CGIN1; KIAA1305; NYNRIN",
        "protein_names_uniprotkb": "Protein NYNRIN; NYN domain and retroviral integrase catalytic domain-containing protein; Protein cousin of GIN1",
        "protein_names_refseq": "Cousin of GIN1; NYN domain and retroviral integrase catalytic domain-containing protein; protein NYNRIN; protein cousin of GIN1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57523)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "17074750;19413330;22898188;23481700;24029068;24715725;25576301;25645385;26992070;27543614;27846572;27862975;27893789;28832583;28834231;29242379;29557506;29786170;29789417;30429286;31154438;31844290;31848261;32157095;32387766;32502341;32938616;33123756;33141586;33392160;34087483;34171305;34509645;35051231;35318648;35580925;36241641;36284347;37938771;38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P153;Q86TR3;Q9HAC4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0004521 RNA endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0036464 cytoplasmic ribonucleoprotein granule",
        "go_biological_process": "GO:0006261 DNA-templated DNA replication;GO:0015074 DNA integration;GO:0061158 3'-UTR-mediated mRNA destabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q9P2P1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKG9-1",
        "uniprot_id": [
            {
                "id": "OCTC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKG9",
                "type": "external"
            }
        ],
        "mass": 70178.0,
        "length": 612,
        "protein_name": "Peroxisomal carnitine O-octanoyltransferase",
        "gene_name": "CROT",
        "organism": "Human",
        "refseq_name": "peroxisomal carnitine O-octanoyltransferase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001137407",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137407",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CROT; COT",
        "gene_names_refseq": "COT; CROT",
        "protein_names_uniprotkb": "Peroxisomal carnitine O-octanoyltransferase; 2.3.1.137; COT",
        "protein_names_refseq": "peroxisomal carnitine O-octanoyltransferase isoform 1; peroxisomal carnitine O-octanoyltransferase; peroxisomal carnitine acyltransferase",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); drug-induced hepatitis (Disease Ontology:DOID:2044); bilirubin metabolic disorder (Disease Ontology:DOID:2741); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:54677);  (R-HSA-389887);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 132,
        "publication_id_list": "10022913;10092594;10486279;10562279;10673331;11001805;11060344;11060359;11101887;11237011;11546814;11781871;11790793;11931631;12456682;12559034;12562770;12578380;12717447;12885776;15060085;15099582;15545321;15599942;15858711;16385454;16756494;16854980;17007944;17726030;18359941;18712838;19054068;19197237;19208625;19584060;19632994;20178365;21554508;21619872;21976670;21980954;22002062;22057399;22371489;22747494;2351134;23963456;24235149;24715725;24865970;25016021;25418920;25538232;25645385;25854684;25880248;25892735;26086376;26138649;26154972;26220973;26344566;26375851;26929215;26992070;27597759;27600516;27846572;27920218;28218747;28521612;28611990;28765278;28787099;28832583;28904123;29242379;29331515;29393594;29437277;29557506;29632046;29786170;30315122;30429286;30524438;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32357974;32502341;32897882;32938616;32983136;33356393;33592498;33691108;33912179;33968037;34087483;34171305;34185709;35051231;35318648;35561310;35580925;36010968;36284347;36587768;7649182;7719337;7790377;8387517;8824437;8858165;8902629;8943006;8991089;9089413;9090381;9090382;9090383;9271077;9539740;9653144;9668159;9837948",
        "class_list": "",
        "function": "Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester., [UniProtKB, PubMed]; CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction., [RefSeq, PubMed]; Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells., [RefSeq, PubMed]; Human CPT1A, CPT1B, CPT2, CROT and CRAT are known to encode active carnitine acyltransferases.  Earlier pfam annotations refer to the non-existing compound CARNITATE.  In 2000 this has been changed to CARNITINE. GeneRIF: CROT encodes carnitine octanoyltransferase, an enzyme known from rat studies to act on products of peroxisomal fatty acid oxidation. Medium-chain acylcarnitines are thought to be transported from peroxisomes to mitochondria. Review article, [RefSeq, PubMed]; Selected 'Tpl2/Cot-YL ribozyme' efficiently cleaves its target sequence in cis and in trans; furthermore, the ribozyme efficiently cleaves a longer target sequence of 54 nucleotides in trans, as well as the full-length mRNA., [RefSeq, PubMed]; These results suggest that CROT activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway., [RefSeq, PubMed]; This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 16,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1D6;E7EQF2;Q86V17;Q8IUW9;Q9Y6I2",
        "ec_number_list": [
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42",
                "type": "external"
            },
            {
                "id": "1.3.3.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "3.4.24.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56",
                "type": "external"
            },
            {
                "id": "1.4.3.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3",
                "type": "external"
            },
            {
                "id": "2.6.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51",
                "type": "external"
            },
            {
                "id": "2.6.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44",
                "type": "external"
            },
            {
                "id": "2.3.1.176",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "2.3.1.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "4.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4",
                "type": "external"
            },
            {
                "id": "2.3.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137",
                "type": "external"
            },
            {
                "id": "2.3.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.5.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "1.4.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.184",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
                "type": "external"
            },
            {
                "id": "1.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38",
                "type": "external"
            },
            {
                "id": "1.3.1.124",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124",
                "type": "external"
            },
            {
                "id": "1.1.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15",
                "type": "external"
            },
            {
                "id": "1.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1",
                "type": "external"
            },
            {
                "id": "1.5.3.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7",
                "type": "external"
            },
            {
                "id": "5.1.99.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4",
                "type": "external"
            },
            {
                "id": "4.1.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63",
                "type": "external"
            },
            {
                "id": "1.2.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008458 carnitine O-octanoyltransferase activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0051791 medium-chain fatty acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q9UKG9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULC6-1",
        "uniprot_id": [
            {
                "id": "PADI1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULC6",
                "type": "external"
            }
        ],
        "mass": 74666.0,
        "length": 663,
        "protein_name": "Protein-arginine deiminase type-1",
        "gene_name": "PADI1",
        "organism": "Human",
        "refseq_name": "protein-arginine deiminase type-1",
        "refseq_ac": [
            {
                "id": "NP_037490",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037490",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PADI1; PAD1; PDI1",
        "gene_names_refseq": "HPAD10; PAD1; PADI1; PDI1; PDI",
        "protein_names_uniprotkb": "Protein-arginine deiminase type-1; 3.5.3.15; Peptidylarginine deiminase I; Protein-arginine deiminase type I",
        "protein_names_refseq": "hPAD-colony 10; peptidyl arginine deiminase, type I; peptidylarginine deiminase I; protein-arginine deiminase type I; protein-arginine deiminase type-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29943);  (R-HSA-3247509)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "11069618;12392711;12416996;15087120;15150696;15339660;15345777;15629448;15675958;17303166;18452278;27393304;27543614;28844713;29242379;29557506;30044909;30379171;31952341;32938616;33741961;34352263;35051231;36284347;38253038",
        "class_list": "",
        "function": "Authors showed that PAD1 interacts with and citrullinates MEK1 thereby disrupting MEK1-catalyzed ERK1/2 phosphorylation, thus leading to the MMP2 overexpression., [RefSeq, PubMed]; Catalyzes the deimination of arginine residues of proteins., [UniProtKB, PubMed, PubMed, PubMed]; Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; Cloning, gene organization, and expression analysis, [RefSeq, PubMed]; Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes: Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation., [RefSeq, PubMed]; PAD1 and 3 are able to modify filaggrin, [RefSeq, PubMed]; Peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13, [RefSeq, PubMed]; This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4K6;Q70SX6",
        "ec_number_list": [
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9ULC6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULW8-1",
        "uniprot_id": [
            {
                "id": "PADI3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULW8",
                "type": "external"
            }
        ],
        "mass": 74743.0,
        "length": 664,
        "protein_name": "Protein-arginine deiminase type-3",
        "gene_name": "PADI3",
        "organism": "Human",
        "refseq_name": "protein-arginine deiminase type-3",
        "refseq_ac": [
            {
                "id": "NP_057317",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057317",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PADI3; PAD3; PDI3",
        "gene_names_refseq": "PAD3; PADI3; PDI3; UHS1",
        "protein_names_uniprotkb": "Protein-arginine deiminase type-3; 3.5.3.15; Peptidylarginine deiminase III; Protein-arginine deiminase type III",
        "protein_names_refseq": "peptidyl arginine deiminase, type III; peptidylarginine deiminase III; protein-arginine deiminase type III; protein-arginine deiminase type-3",
        "tax_id": 9606,
        "disease": "uncombable hair syndrome 1 (MONDO:MONDO:0020736)",
        "pathway": " (hsa:51702);  (R-HSA-3247509)",
        "pathway_count": 2,
        "publication_count": 16,
        "publication_id_list": "11069618;12392711;12416996;15087120;15150696;15339660;15345777;15629448;16959974;17303166;27866708;33573274;33741961;33971157;35580925;39206995",
        "class_list": "",
        "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, PubMed]; Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; PADI3 inhibits epithelial-mesenchymal transition by targeting CKS1-induced signal transduction in colon cancer., [RefSeq, PubMed]; Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures. Publication Status: Online-Only, [RefSeq, PubMed]; Peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13, [RefSeq, PubMed]; Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design., [RefSeq, PubMed]; This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q58EY7;Q70SX5",
        "ec_number_list": [
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9ULW8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y585-1",
        "uniprot_id": [
            {
                "id": "OR1A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y585",
                "type": "external"
            }
        ],
        "mass": 34396.0,
        "length": 309,
        "protein_name": "Olfactory receptor 1A2",
        "gene_name": "OR1A2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 1A2",
        "refseq_ac": [
            {
                "id": "NP_036484",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036484",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR1A2",
        "gene_names_refseq": "OR17-6; OR1A2",
        "protein_names_uniprotkb": "Olfactory receptor 1A2; OR17-6; Olfactory receptor 17-6; Olfactory receptor OR17-10",
        "protein_names_refseq": "olfactory receptor 17-6; olfactory receptor 1A2; olfactory receptor OR17-10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26189);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "10673334;14983052;17601748;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Evolutionary conserved amino acid residues to be necessary for specific responsiveness of OR1A1 to odorants were identified., [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KPH3;Q6IFM0;Q6NTD8;Q96R86",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0032467 positive regulation of cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q9Y585-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86WC4-1",
        "uniprot_id": [
            {
                "id": "OSTM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86WC4",
                "type": "external"
            }
        ],
        "mass": 37257.0,
        "length": 334,
        "protein_name": "Osteopetrosis-associated transmembrane protein 1",
        "gene_name": "OSTM1",
        "organism": "Human",
        "refseq_name": "osteopetrosis-associated transmembrane protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_054747",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054747",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OSTM1; GL; HSPC019; PRO21201",
        "gene_names_refseq": "GIPN; GL; HSPC019; OPTB5; OSTM1",
        "protein_names_uniprotkb": "Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit",
        "protein_names_refseq": "CLCN7 accessory beta subunit; GAIP-interacting protein N terminus; chloride channel 7 beta subunit; grey-lethal osteopetrosis; osteopetrosis associated transmembrane protein 1; osteopetrosis-associated transmembrane protein 1 precursor",
        "tax_id": 9606,
        "disease": "autosomal recessive osteopetrosis 5 (Disease Ontology:DOID:0110939)",
        "pathway": " (hsa:28962);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 135,
        "publication_id_list": "10.1101/2023.09.13.557529;10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12079282;12393854;12627228;12826607;12907679;12975309;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17081983;17381423;17448995;17699613;17881003;17922613;17985267;18000046;18063579;18310267;18400985;18449189;18508966;18578522;18662336;18669648;18724360;18767875;19153159;19307298;19380724;19387438;19413330;19620632;19651622;19664995;19690332;19808995;19953639;20068231;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23112050;23186163;2321095;23481700;23616951;24190977;24275569;2536303;25645385;26359375;26562072;28071645;28154142;28790369;28832583;29242379;29741879;30429286;30833945;31092671;31154438;31844290;31848261;32157095;32161166;32350084;32387766;32488085;32938616;32983136;33298915;33592498;33912179;33968037;34171305;34509645;35051231;35251023;35289036;35902071;37074911;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "A novel mutation affecting the OSTM1 locus responsible for ARO. In addition to common clinical features of osteopetrosis, the patient developed a unique neuronal pathology that provided evidence for the role of OSTM1 in normal neuronal cell development., [RefSeq, PubMed]; Mutation in the human GL gene leads to severe recessive osteopetrosis, [RefSeq, PubMed]; OSTM1 pleiotropic roles from osteopetrosis to neurodegeneration., [RefSeq, PubMed]; Required for osteoclast and melanocyte maturation and function., [UniProtKB, PubMed]; The human GIPN gene has 6 exons and 5 introns, and encodes a 334-aa protein., [RefSeq, PubMed]; This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]., [RefSeq]; This study reports on a 12-month-old female with recessive OSMT1 mutations and neuroimaging findings suggesting a malignant infantile osteopetrosis., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 44,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5E3;Q5R391;Q6PCA7;Q7RTW6;Q8NC29;Q8TC82;Q9Y2S9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0030321 transepithelial chloride transport",
        "synthesized_glycan_count": 0,
        "hit_score": 18.9,
        "record_id": "Q86WC4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGY3-1",
        "uniprot_id": [
            {
                "id": "OR6K3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGY3",
                "type": "external"
            }
        ],
        "mass": 37352.0,
        "length": 331,
        "protein_name": "Olfactory receptor 6K3",
        "gene_name": "OR6K3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6K3",
        "refseq_ac": [
            {
                "id": "NP_001005327",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005327",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6K3",
        "gene_names_refseq": "OR1-18; OR6K3",
        "protein_names_uniprotkb": "Olfactory receptor 6K3; Olfactory receptor OR1-18",
        "protein_names_refseq": "olfactory receptor 6K3; olfactory receptor OR1-18; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:391114);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "11237011;14983052;21248752;24800820;27515280;29351928;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VUV0;Q6IFR5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8NGY3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P47888-1",
        "uniprot_id": [
            {
                "id": "OR3A3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P47888",
                "type": "external"
            }
        ],
        "mass": 34963.0,
        "length": 321,
        "protein_name": "Olfactory receptor 3A3",
        "gene_name": "OR3A3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 3A3",
        "refseq_ac": [
            {
                "id": "NP_036505",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036505",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR3A3; OR3A6; OR3A7; OR3A8P",
        "gene_names_refseq": "OR17-137; OR17-16; OR17-201; OR3A3; OR3A6; OR3A7; OR3A8P",
        "protein_names_uniprotkb": "Olfactory receptor 3A3; OR17-201; Olfactory receptor 17-201; Olfactory receptor 3A6; Olfactory receptor 3A7; Olfactory receptor 3A8; Olfactory receptor OR17-22",
        "protein_names_refseq": "olfactory receptor 17-201; olfactory receptor 3A3; olfactory receptor 3A6; olfactory receptor 3A7; olfactory receptor 3A8; olfactory receptor OR17-22; olfactory receptor, family 3, subfamily A, member 6; olfactory receptor, family 3, subfamily A, member 7; olfactory receptor, family 3, subfamily A, member 8 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8392);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 13,
        "publication_id_list": "10673334;11237011;14983052;24800820;27515280;31974307;32066986;32488085;33141586;33912179;34561969;35051231;8004088",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2VPE4;Q6IFM6;Q9P1Q4;Q9UBE7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "P47888-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGE7-1",
        "uniprot_id": [
            {
                "id": "OR9K2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGE7",
                "type": "external"
            }
        ],
        "mass": 37746.0,
        "length": 335,
        "protein_name": "Olfactory receptor 9K2",
        "gene_name": "OR9K2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 9K2",
        "refseq_ac": [
            {
                "id": "NP_001005243",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005243",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR9K2",
        "gene_names_refseq": "OR12-2; OR9K2",
        "protein_names_uniprotkb": "Olfactory receptor 9K2; Olfactory receptor OR12-2",
        "protein_names_refseq": "olfactory receptor 9K2; olfactory receptor OR12-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441639);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "11237011;14983052;24800820;27515280;30524438;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EH19;Q6IFD6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGE7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG2-1",
        "uniprot_id": [
            {
                "id": "OR5T2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG2",
                "type": "external"
            }
        ],
        "mass": 40696.0,
        "length": 359,
        "protein_name": "Olfactory receptor 5T2",
        "gene_name": "OR5T2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5T2",
        "refseq_ac": [
            {
                "id": "NP_001004746",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004746",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5T2",
        "gene_names_refseq": "OR11-177; OR5T2",
        "protein_names_uniprotkb": "Olfactory receptor 5T2; Olfactory receptor OR11-177",
        "protein_names_refseq": "olfactory receptor 5T2; olfactory receptor OR11-177",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219464);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "11237011;14983052;24800820;27515280;31154438;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGX5;Q6IFC8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGG2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00110-1",
        "uniprot_id": [
            {
                "id": "OVOL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00110",
                "type": "external"
            }
        ],
        "mass": 21314.0,
        "length": 190,
        "protein_name": "Putative transcription factor ovo-like protein 3",
        "gene_name": "OVOL3",
        "organism": "Human",
        "refseq_name": "putative transcription factor ovo-like protein 3",
        "refseq_ac": [
            {
                "id": "NP_001289686",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289686",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OVOL3",
        "gene_names_refseq": "HOVO3; OVOL3",
        "protein_names_uniprotkb": "Putative transcription factor ovo-like protein 3",
        "protein_names_refseq": "OVO homolog-like 3; ovo-like 3; putative transcription factor ovo-like protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728361)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;22737237",
        "class_list": "",
        "function": "May act as a transcription regulator., [UniProtKB]; Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions in humans and other species, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0J9YVN9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0009968 negative regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "O00110-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43614-1",
        "uniprot_id": [
            {
                "id": "OX2R_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43614",
                "type": "external"
            }
        ],
        "mass": 50694.0,
        "length": 444,
        "protein_name": "Orexin receptor type 2",
        "gene_name": "HCRTR2",
        "organism": "Human",
        "refseq_name": "orexin receptor type 2",
        "refseq_ac": [
            {
                "id": "NP_001517",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001517",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCRTR2; ORXR2; OX2R; OXR2",
        "gene_names_refseq": "HCRTR2; ORXR2; OX2R; OXR2",
        "protein_names_uniprotkb": "Orexin receptor type 2; Hypocretin receptor type 2; Ox-2-R; Ox2-R; Ox2R",
        "protein_names_refseq": "hypocretin (orexin) receptor 2; hypocretin receptor type 2; orexin receptor type 2; orexin type-2 receptor",
        "tax_id": 9606,
        "disease": "hyperglycemia (Disease Ontology:DOID:4195); narcolepsy (Disease Ontology:DOID:8986)",
        "pathway": " (hsa:3062);  (R-HSA-389397);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 47,
        "publication_id_list": "10191087;10364220;10567430;10583376;10727532;10861009;11015615;11024015;11030716;11574155;11723285;11742120;11753430;12120503;12714592;15951850;16182515;16268778;16339447;16429482;16754659;16923326;18434541;18515384;18577758;18936096;1905813;25533960;26950369;2841328;3086311;31860301;33547286;35614071;36417909;36901420;37054895;37264001;37264034;37418013;38898624;7937899;8664309;9224703;9305846;9491897;9770463",
        "class_list": "",
        "function": "Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype., [RefSeq, PubMed]; G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:26950369, PubMed:33547286, PubMed:35614071, PubMed:9491897). Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades (PubMed:35614071). Involved in regulating the sleep-wake cycle (By similarity). Contributes to central regulation of glucose homeostasis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; High-resolution HLA sequencing and hypocretin receptor 2 autoantibodies in narcolepsy type 1 and type 2., [RefSeq, PubMed]; Internal and external modulation factors of the orexin system (REVIEW). Review article, [RefSeq, PubMed]; Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VTM0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0016499 orexin receptor activity;GO:0008188 neuropeptide receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus;GO:0042593 glucose homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "O43614-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95222-1",
        "uniprot_id": [
            {
                "id": "OR6A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95222",
                "type": "external"
            }
        ],
        "mass": 36154.0,
        "length": 327,
        "protein_name": "Olfactory receptor 6A2",
        "gene_name": "OR6A2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6A2",
        "refseq_ac": [
            {
                "id": "NP_003687",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003687",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6A2; OR6A1; OR6A2P",
        "gene_names_refseq": "I7; OR11-55; OR6A1; OR6A2P; OR6A2",
        "protein_names_uniprotkb": "Olfactory receptor 6A2; OR11-55; Olfactory receptor 11-55; Olfactory receptor 6A1; Olfactory receptor OR11-83; hP2 olfactory receptor",
        "protein_names_refseq": "hI7 olfactory receptor; hP2 olfactory receptor; olfactory receptor 11-55; olfactory receptor 6A1; olfactory receptor 6A2; olfactory receptor OR11-83; olfactory receptor, family 6, subfamily A, member 1; olfactory receptor, family 6, subfamily A, member 2 pseudogene; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8590);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 13,
        "publication_id_list": "11416212;14983052;20608641;24800820;27515280;31530632;31974307;32066986;33141586;35025664;35283015;38253038;9787077",
        "class_list": "",
        "function": "I7 olfactory receptor, [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Odorant receptors in macrophages: potential targets for atherosclerosis., [RefSeq, PubMed]; Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production., [RefSeq, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MJC7;Q6IF35;Q9H206",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "O95222-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C604-1",
        "uniprot_id": [
            {
                "id": "OR4A8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C604",
                "type": "external"
            }
        ],
        "mass": 35621.0,
        "length": 315,
        "protein_name": "Olfactory receptor 4A8",
        "gene_name": "OR4A8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR4A8; OR4A8P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 4A8; Olfactory receptor OR11-110",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "12644552;12730696;14983052;24800820;27515280;31092671;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P0C604-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C7N5-1",
        "uniprot_id": [
            {
                "id": "OR8U9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7N5",
                "type": "external"
            }
        ],
        "mass": 35054.0,
        "length": 309,
        "protein_name": "Olfactory receptor 8U9",
        "gene_name": "OR8U9",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8U9",
        "refseq_ac": [
            {
                "id": "NP_001013375",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013375",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8U9",
        "gene_names_refseq": "OR8U9",
        "protein_names_uniprotkb": "Olfactory receptor 8U9",
        "protein_names_refseq": "olfactory receptor 8U9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:504190);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "24800820;27515280;31974307;32066986;33592498;33968037",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P0C7N5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C7N8-1",
        "uniprot_id": [
            {
                "id": "OR9G9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7N8",
                "type": "external"
            }
        ],
        "mass": 34020.0,
        "length": 305,
        "protein_name": "Olfactory receptor 9G9",
        "gene_name": "OR9G9",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR9G9",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 9G9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:504191);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "24800820;27515280;31844290;31974307;32066986;35580925",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P0C7N8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DMU2-1",
        "uniprot_id": [
            {
                "id": "OR8G3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DMU2",
                "type": "external"
            }
        ],
        "mass": 34506.0,
        "length": 310,
        "protein_name": "Olfactory receptor 8G3",
        "gene_name": "OR8G3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR8G3; OR8G3P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 8G3; Olfactory receptor OR11-297",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "11237011;14983052",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15614;Q6IF38",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P0DMU2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000100.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P83859-1",
        "uniprot_id": [
            {
                "id": "OX26_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P83859",
                "type": "external"
            }
        ],
        "mass": 14941.0,
        "length": 136,
        "protein_name": "Orexigenic neuropeptide QRFP",
        "gene_name": "QRFP",
        "organism": "Human",
        "refseq_name": "orexigenic neuropeptide QRFP preproprotein",
        "refseq_ac": [
            {
                "id": "NP_937823",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937823",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "QRFP",
        "gene_names_refseq": "26RFa; P518; QRFP",
        "protein_names_uniprotkb": "Orexigenic neuropeptide QRFP; Neuropeptide RF-amide; P518; Pyroglutamylated arginine-phenylalanine-amide peptide",
        "protein_names_refseq": "P518 precursor protein; RF(Arg-Phe)amide family 26 amino acid peptide (P518); orexigenic neuropeptide QRFP preproprotein; orexigenic neuropeptide QRFP; prepro-26RFa; prepro-QRFP",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347148);  (R-HSA-389397);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 41,
        "publication_id_list": "10191087;10364220;10567430;10583376;10727532;10861009;11015615;11024015;11030716;11574155;11742120;11753430;12120503;12714592;12960173;14657341;15808908;15951850;16182515;16268778;16339447;16429482;16754659;16899066;16923326;18434541;18515384;18577758;18936096;1905813;25858563;2841328;30483810;30783092;3086311;7937899;8664309;9224703;9305846;9491897;9770463",
        "class_list": "",
        "function": "Characterization of 26RFa-related peptides showed that two distinct molecular forms of 26RFa are present in the human hypothalamus and spinal cord, i.e. 26RFa and an N-terminally elongated form of 43 amino acids designated 43RFa., [RefSeq, PubMed]; P518 exhibited high affinity for SP9155. The peptide P518 precursor gene is predominantly expressed in various brain regions, coronary arteries, thyroid and parathyroid glands, large intestine, colon, bladder, testes, and prostate., [RefSeq, PubMed]; Solution conformation of 26RFa by using two-dimensional NMR spectroscopy in different media was investigated., [RefSeq, PubMed]; Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)., [UniProtKB, PubMed, PubMed]; The expression of both QRFP and GPR103 at the gene and protein level was higher in human prostate cancer tissue samples compared to control and benign prostatic hyperplasia samples., [RefSeq, PubMed]; This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]., [RefSeq]; We show a moderate positive correlation between plasma 26RFa levels and insulin in patients with diabetes. Plasma 26RFa increases in response to glucose tolerance test. 26RFa and its receptor GPR103 are present in human pancreatic beta-cells and gut., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A3KFJ6;Q495K6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031854 orexigenic neuropeptide QRFP receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0045777 positive regulation of blood pressure;GO:0060259 regulation of feeding behavior;GO:0007625 grooming behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "P83859-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15072-1",
        "uniprot_id": [
            {
                "id": "OZF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15072",
                "type": "external"
            }
        ],
        "mass": 33308.0,
        "length": 292,
        "protein_name": "Zinc finger protein OZF",
        "gene_name": "ZNF146",
        "organism": "Human",
        "refseq_name": "zinc finger protein OZF",
        "refseq_ac": [
            {
                "id": "NP_001093108",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093108",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF146; OZF",
        "gene_names_refseq": "OZF; ZNF146",
        "protein_names_uniprotkb": "Zinc finger protein OZF; Only zinc finger protein; Zinc finger protein 146",
        "protein_names_refseq": "only zinc finger protein; zinc finger protein OZF",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7705)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "11306801;12754738;15838871;15881673;24715725;25418920;25576301;26811146;26929215;26992070;27846572;27920218;28063628;28228285;28832583;28904123;29242379;29393594;29557506;29632046;30315122;30429286;30484775;31154438;31844290;31848261;32157095;32265295;32387766;32983136;33141586;33392160;33394291;33592498;33936100;35051231;35100360;35318648;35580925;37762228;38614125;8107129;8665923;9935176",
        "class_list": "",
        "function": "LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146., [RefSeq, PubMed]; Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; ZNF146/OZF and ZNF507 target LINE-1 sequences., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2TB94",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q15072-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15617-1",
        "uniprot_id": [
            {
                "id": "OR8G1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15617",
                "type": "external"
            }
        ],
        "mass": 34904.0,
        "length": 311,
        "protein_name": "Olfactory receptor 8G1",
        "gene_name": "OR8G1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8G1",
        "refseq_ac": [
            {
                "id": "NP_001002905",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002905",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8G1; OR8G1P",
        "gene_names_refseq": "HSTPCR25; OR8G1P; OR8G1; TPCR25",
        "protein_names_uniprotkb": "Olfactory receptor 8G1; Olfactory receptor OR11-281; Olfactory receptor TPCR25",
        "protein_names_refseq": "olfactory receptor 8G1; olfactory receptor OR11-281; olfactory receptor TPCR25; olfactory receptor, family 8, subfamily G, member 1 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26494);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "14983052;17973576;24800820;27515280;28904123;31974307;32066986;9119360",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NG88",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q15617-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3SYA9-1",
        "uniprot_id": [
            {
                "id": "P12L1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3SYA9",
                "type": "external"
            }
        ],
        "mass": 45448.0,
        "length": 428,
        "protein_name": "Putative POM121-like protein 1",
        "gene_name": "POM121L1P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "POM121L1P; POM121L1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative POM121-like protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "30379171;31217245",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q3SYA9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5MIZ7-1",
        "uniprot_id": [
            {
                "id": "P4R3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5MIZ7",
                "type": "external"
            }
        ],
        "mass": 97458.0,
        "length": 849,
        "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 3B",
        "gene_name": "PPP4R3B",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001269779",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269779",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP4R3B; KIAA1387; PP4R3B; SMEK2",
        "gene_names_refseq": "FLFL2; PP4R3B; PPP4R3B; PSY2; SMEK2; smk1",
        "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 3B; SMEK homolog 2",
        "protein_names_refseq": "SMEK homolog 2, suppressor of mek1; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 3; serine/threonine-protein phosphatase 4 regulatory subunit 3B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57223)",
        "pathway_count": 1,
        "publication_count": 75,
        "publication_id_list": "10.1101/2023.09.13.557529;11230166;15616564;16085932;16964243;18487071;18614045;21406692;23186163;23481700;24715725;25505266;25576301;25645385;25880248;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30484775;30524438;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34509645;34561969;34725712;34932366;35051231;35254053;35318648;35494241;35580925;36010968;36215666;36241641;36284347;40307207;40914422",
        "class_list": "",
        "function": "A three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication., [RefSeq, PubMed]; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P9B0;Q86XB8;Q9BQJ0;Q9BRK2;Q9H913;Q9P2G0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0072542 protein phosphatase activator activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0000785 chromatin",
        "go_biological_process": "GO:0006974 DNA damage response;GO:2000779 regulation of double-strand break repair",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q5MIZ7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IEU7-1",
        "uniprot_id": [
            {
                "id": "OR5MA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IEU7",
                "type": "external"
            }
        ],
        "mass": 35592.0,
        "length": 315,
        "protein_name": "Olfactory receptor 5M10",
        "gene_name": "OR5M10",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5M10",
        "refseq_ac": [
            {
                "id": "NP_001004741",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004741",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5M10",
        "gene_names_refseq": "OR11-207; OR5M10",
        "protein_names_uniprotkb": "Olfactory receptor 5M10; Olfactory receptor OR11-207",
        "protein_names_refseq": "olfactory receptor 5M10; olfactory receptor OR11-207",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390167);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231;35494241",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIL9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q6IEU7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z3T1-1",
        "uniprot_id": [
            {
                "id": "OR2W3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z3T1",
                "type": "external"
            }
        ],
        "mass": 34789.0,
        "length": 314,
        "protein_name": "Olfactory receptor 2W3",
        "gene_name": "OR2W3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2W3",
        "refseq_ac": [
            {
                "id": "NP_001001957",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001957",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2W3; OR2W3P; OR2W8P",
        "gene_names_refseq": "OR2W3P; OR2W3; OR2W8P; OST718",
        "protein_names_uniprotkb": "Olfactory receptor 2W3; Olfactory receptor 2W8; Olfactory receptor OR1-49",
        "protein_names_refseq": "olfactory receptor 2W3; olfactory receptor 2W8; olfactory receptor OR1-49; olfactory receptor, family 2, subfamily W, member 3 pseudogene; olfactory receptor, family 2, subfamily W, member 8 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:343171);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 32,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25374392;25783483;25784876;25825126;25847845;25977809;26373539;26891008;27515280;27916747;27916748;28262088;28656349;29235485;31040214;31974307;32066986;32387766;33097666;33968037;34509645;35051231",
        "class_list": "",
        "function": "A novel missense mutation, c. 424 C > T transition (p.R142W) in OR2W3 gene, was identified as a potentially causative mutation for autosomal dominant Retinitis pigmentosa. Publication Status: Online-Only, [RefSeq, PubMed]; A signal in a nearby olfactory receptor on chromosome 1, olfactory receptor family 2 subfamily L member 13 (OR2L13), tagged by rs151319968, was nominally associated with PTSD in the AI sample. Although no variants were significantly associated after correction for multiple testing in a meta-analysis of the two cohorts, pathway analysis of the top hits showed an enrichment cluster of terms related to sensory transduction., [RefSeq, PubMed]; OR2W3 is associated with genetic susceptibility to Japanese male infertility., [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Our results provided a new insight into susceptibility of USF1 variant with male infertility. rs11204546 of OR2W3 and rs11677854 of GTF2A1L might be additional valuable molecular predictive markers, [RefSeq, PubMed]; The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR., [RefSeq, PubMed]; This outstanding specificity of extremely narrowly tuned human OR2M3 can explain both odor qualities and odor threshold trend within a homologous series of 3-mercapto-2-methylalkan-1-ols and suggests a modern human-specific, food-related function of OR2M3 in detecting a single onion key food odorant., [RefSeq, PubMed]; We therefore conclude that this sequence variant, and hence the OR2W3 gene, do not cause RP. Prompted by these findings and based on simple principles of population genetics, we suggest that WES studies should consider DNA variants as the possible cause of dominant RP only if they are present in less than 1:100,000 individuals from the general population. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF06;Q8NG86",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q7Z3T1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N148-1",
        "uniprot_id": [
            {
                "id": "OR6V1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N148",
                "type": "external"
            }
        ],
        "mass": 34902.0,
        "length": 313,
        "protein_name": "Olfactory receptor 6V1",
        "gene_name": "OR6V1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6V1",
        "refseq_ac": [
            {
                "id": "NP_001001667",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001667",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6V1",
        "gene_names_refseq": "GPR138; OR6V1",
        "protein_names_uniprotkb": "Olfactory receptor 6V1; Olfactory receptor OR7-3",
        "protein_names_refseq": "olfactory receptor 6V1; olfactory receptor OR7-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:346517);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "12732197;14983052;24800820;27515280;31974307;32066986;32387766",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; This publication uses 'GPR138' as a name for this gene., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2I0;B9EH48;Q6IF70",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8N148-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NG98-1",
        "uniprot_id": [
            {
                "id": "OR7D4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NG98",
                "type": "external"
            }
        ],
        "mass": 34448.0,
        "length": 312,
        "protein_name": "Olfactory receptor 7D4",
        "gene_name": "OR7D4",
        "organism": "Human",
        "refseq_name": "olfactory receptor 7D4",
        "refseq_ac": [
            {
                "id": "NP_001005191",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005191",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR7D4; OR7D4P",
        "gene_names_refseq": "OR19-7; OR19-B; OR19B; OR7D4P; OR7D4; hg105",
        "protein_names_uniprotkb": "Olfactory receptor 7D4; OR19-B; Odorant receptor family subfamily D member 4RT; Olfactory receptor OR19-7",
        "protein_names_refseq": "odorant receptor family 7 subfamily D member 4 RT; olfactory receptor 7D4; olfactory receptor OR19-7; olfactory receptor, family 7, subfamily D, member 4 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:125958);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 28,
        "publication_id_list": "10460249;14983052;15598656;17509148;17601748;17873857;17973576;19474308;19581598;21093532;22044667;22567099;24316890;24800820;25784876;25977809;26072518;26373539;27515280;27916747;27916748;28656349;29235485;29246659;31040214;31974307;32066986;35051231",
        "class_list": "",
        "function": "Data is consistent with the idea that OR7D4 genotype predicts the sensory perception of meat containing androstenone and that genetic variation in an odorant receptor can alter food preferences., [RefSeq, PubMed]; Genotypic variation in OR7D4 accounts for a significant proportion of the valence (pleasantness or unpleasantness) and intensity variance in perception of these steroidal odours, [RefSeq, PubMed]; Impact of genotypic variations of the androstadienone (AND)-receptor OR7D4, as well as the influence of participant sex and concomitant hormonal fluctuations on AND-action during emotional interference processing, olfactory performance and mood assessments., [RefSeq, PubMed]; Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Results suggest non-neutral evolution for an olfactory receptor gene, [RefSeq, PubMed]; The results suggested that odor perception between heterosexual partners may have an impact on the development of depression and anxiety, and that it might be influenced by genetic variation in OR7D4., [RefSeq, PubMed]; This study suggested that OR7D4 sequence variant (rs2878329 G>A) showed evidence of association with reduced levels of adiposity (p=0.03), cognitive dietary restraint (p=0.05) and susceptibility to hunger (p=0.008)., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8CAH8;A8CAH9;A8CAI0;A8CAI1;B9EH79",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q8NG98-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG3-1",
        "uniprot_id": [
            {
                "id": "OR5T3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG3",
                "type": "external"
            }
        ],
        "mass": 38346.0,
        "length": 340,
        "protein_name": "Olfactory receptor 5T3",
        "gene_name": "OR5T3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5T3",
        "refseq_ac": [
            {
                "id": "NP_001004747",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004747",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5T3",
        "gene_names_refseq": "OR11-178; OR5T3Q; OR5T3",
        "protein_names_uniprotkb": "Olfactory receptor 5T3; Olfactory receptor OR11-178",
        "protein_names_refseq": "olfactory receptor 5T3; olfactory receptor OR11-178",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390154);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "11237011;14983052;24800820;27515280;29731959;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFC7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGG3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG8-1",
        "uniprot_id": [
            {
                "id": "OR8B3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG8",
                "type": "external"
            }
        ],
        "mass": 35305.0,
        "length": 313,
        "protein_name": "Olfactory receptor 8B3",
        "gene_name": "OR8B3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8B3",
        "refseq_ac": [
            {
                "id": "NP_001005467",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005467",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8B3",
        "gene_names_refseq": "OR11-311; OR8B3",
        "protein_names_uniprotkb": "Olfactory receptor 8B3; Olfactory receptor OR11-311",
        "protein_names_refseq": "olfactory receptor 8B3; olfactory receptor OR11-311",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390271);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 21,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFQ8;Q8NGH1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8NGG8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGL0-1",
        "uniprot_id": [
            {
                "id": "OR5L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGL0",
                "type": "external"
            }
        ],
        "mass": 34682.0,
        "length": 311,
        "protein_name": "Olfactory receptor 5L2",
        "gene_name": "OR5L2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5L2",
        "refseq_ac": [
            {
                "id": "NP_001004739",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004739",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5L2",
        "gene_names_refseq": "HSHTPCRX16; HTPCRX16; OR11-153; OR5L2",
        "protein_names_uniprotkb": "Olfactory receptor 5L2; HTPCRX16; Olfactory receptor OR11-153",
        "protein_names_refseq": "olfactory receptor 5L2; olfactory receptor OR11-153; olfactory receptor, family 5, subfamily L, member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26338);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "1370859;14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF66;Q96RB2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NGL0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGL7-1",
        "uniprot_id": [
            {
                "id": "OR4P4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGL7",
                "type": "external"
            }
        ],
        "mass": 35795.0,
        "length": 312,
        "protein_name": "Olfactory receptor 4P4",
        "gene_name": "OR4P4",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4P4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001004124",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004124",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4P4; OR4P3P",
        "gene_names_refseq": "OR4P3P; OR4P4",
        "protein_names_uniprotkb": "Olfactory receptor 4P4; Olfactory receptor 4P3",
        "protein_names_refseq": "olfactory receptor 4P3; olfactory receptor 4P4 isoform 1; olfactory receptor 4P4; olfactory receptor, family 4, subfamily P, member 3 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81300);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "23481700;24800820;27515280;30429286;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGL7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGP3-1",
        "uniprot_id": [
            {
                "id": "OR5M9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGP3",
                "type": "external"
            }
        ],
        "mass": 35093.0,
        "length": 310,
        "protein_name": "Olfactory receptor 5M9",
        "gene_name": "OR5M9",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5M9",
        "refseq_ac": [
            {
                "id": "NP_001004743",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004743",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5M9",
        "gene_names_refseq": "OR11-190; OR5M9",
        "protein_names_uniprotkb": "Olfactory receptor 5M9; Olfactory receptor OR11-190",
        "protein_names_refseq": "olfactory receptor 5M9; olfactory receptor OR11-190",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390162);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEW5;Q96RB9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NGP3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGT1-1",
        "uniprot_id": [
            {
                "id": "OR2K2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGT1",
                "type": "external"
            }
        ],
        "mass": 35045.0,
        "length": 316,
        "protein_name": "Olfactory receptor 2K2",
        "gene_name": "OR2K2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2K2",
        "refseq_ac": [
            {
                "id": "NP_995581",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995581",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2K2; OR2AR1P",
        "gene_names_refseq": "HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P; OR2K2",
        "protein_names_uniprotkb": "Olfactory receptor 2K2; HTPCRH06; Olfactory receptor OR9-17",
        "protein_names_refseq": "olfactory receptor 2K2; olfactory receptor OR9-17; olfactory receptor, family 2, subfamily AN, member 1 pseudogene; olfactory receptor, family 2, subfamily AR, member 1 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26248);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "11237011;14983052;24800820;27515280;31974307;32066986;38540444",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory Receptor OR2K2 Expression in Human Choroid Plexus as a Potential Marker in Early Sporadic Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2TA61;Q5VYK4;Q6IFI5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NGT1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGU1-1",
        "uniprot_id": [
            {
                "id": "OR9A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGU1",
                "type": "external"
            }
        ],
        "mass": 35431.0,
        "length": 314,
        "protein_name": "Olfactory receptor 9A1",
        "gene_name": "OR9A1P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR9A1P; OR9A1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 9A1; HSHTPRX06",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "1370859",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q8NGU1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGV0-1",
        "uniprot_id": [
            {
                "id": "OR2Y1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGV0",
                "type": "external"
            }
        ],
        "mass": 34731.0,
        "length": 311,
        "protein_name": "Olfactory receptor 2Y1",
        "gene_name": "OR2Y1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2Y1",
        "refseq_ac": [
            {
                "id": "NP_001001657",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001657",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2Y1",
        "gene_names_refseq": "OR2Y1; OR5-2",
        "protein_names_uniprotkb": "Olfactory receptor 2Y1; Olfactory receptor OR5-2",
        "protein_names_refseq": "olfactory receptor 2Y1; olfactory receptor OR5-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:134083);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "14983052;24800820;27515280;28467828;31974307;32066986;35051231;35494241",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIP1;Q6IFB1;Q96R16",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8NGV0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGW1-1",
        "uniprot_id": [
            {
                "id": "OR6B3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGW1",
                "type": "external"
            }
        ],
        "mass": 37232.0,
        "length": 331,
        "protein_name": "Olfactory receptor 6B3",
        "gene_name": "OR6B3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6B3",
        "refseq_ac": [
            {
                "id": "NP_775486",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775486",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6B3; OR6B3P",
        "gene_names_refseq": "OR6B3P; OR6B3Q; OR6B3",
        "protein_names_uniprotkb": "Olfactory receptor 6B3; Olfactory receptor OR2-2",
        "protein_names_refseq": "olfactory receptor 6B3; olfactory receptor OR2-2; olfactory receptor, family 6, subfamily B, member 3 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150681);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31154438;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFH3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NGW1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH40-1",
        "uniprot_id": [
            {
                "id": "OR6S1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH40",
                "type": "external"
            }
        ],
        "mass": 36127.0,
        "length": 331,
        "protein_name": "Olfactory receptor 6S1",
        "gene_name": "OR6S1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6S1",
        "refseq_ac": [
            {
                "id": "NP_001001968",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001968",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6S1",
        "gene_names_refseq": "OR14-37; OR6S1Q; OR6S1",
        "protein_names_uniprotkb": "Olfactory receptor 6S1; Olfactory receptor OR14-37",
        "protein_names_refseq": "olfactory receptor 6S1; olfactory receptor OR14-37",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:341799);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFJ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NH40-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH41-1",
        "uniprot_id": [
            {
                "id": "OR4KF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH41",
                "type": "external"
            }
        ],
        "mass": 36484.0,
        "length": 324,
        "protein_name": "Olfactory receptor 4K15",
        "gene_name": "OR4K15",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4K15",
        "refseq_ac": [
            {
                "id": "NP_001005486",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005486",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4K15",
        "gene_names_refseq": "OR14-20; OR4K15Q; OR4K15",
        "protein_names_uniprotkb": "Olfactory receptor 4K15; Olfactory receptor OR14-20",
        "protein_names_refseq": "olfactory receptor 4K15; olfactory receptor OR14-20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81127);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIL3;Q6IEZ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NH41-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH42-1",
        "uniprot_id": [
            {
                "id": "OR4KD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH42",
                "type": "external"
            }
        ],
        "mass": 34261.0,
        "length": 304,
        "protein_name": "Olfactory receptor 4K13",
        "gene_name": "OR4K13",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4K13",
        "refseq_ac": [
            {
                "id": "NP_001004714",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004714",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4K13",
        "gene_names_refseq": "OR14-27; OR4K13",
        "protein_names_uniprotkb": "Olfactory receptor 4K13; Olfactory receptor OR14-27",
        "protein_names_refseq": "olfactory receptor 4K13; olfactory receptor OR14-27",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390433);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF13",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NH42-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH83-1",
        "uniprot_id": [
            {
                "id": "OR4A5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH83",
                "type": "external"
            }
        ],
        "mass": 34915.0,
        "length": 315,
        "protein_name": "Olfactory receptor 4A5",
        "gene_name": "OR4A5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4A5",
        "refseq_ac": [
            {
                "id": "NP_001005272",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005272",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4A5",
        "gene_names_refseq": "OR11-111; OR4A5",
        "protein_names_uniprotkb": "Olfactory receptor 4A5; Olfactory receptor OR11-111",
        "protein_names_refseq": "olfactory receptor 4A5; olfactory receptor OR11-111; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81318);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF84",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NH83-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH85-1",
        "uniprot_id": [
            {
                "id": "OR5R1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH85",
                "type": "external"
            }
        ],
        "mass": 36708.0,
        "length": 324,
        "protein_name": "Olfactory receptor 8U3",
        "gene_name": "OR8U3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8U3",
        "refseq_ac": [
            {
                "id": "NP_001004744",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004744",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8U3; OR5R1P; OR5R1",
        "gene_names_refseq": "OR11-185; OR5R1P; OR5R1; OR8U3",
        "protein_names_uniprotkb": "Olfactory receptor 8U3; Olfactory receptor 5R1; Olfactory receptor OR11-185",
        "protein_names_refseq": "olfactory receptor 5R1; olfactory receptor 8U3; olfactory receptor OR11-185; olfactory receptor family 5 subfamily R member 1; olfactory receptor, family 5, subfamily R, member 1 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219479);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NH85-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WZ84-1",
        "uniprot_id": [
            {
                "id": "OR8D1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WZ84",
                "type": "external"
            }
        ],
        "mass": 34445.0,
        "length": 308,
        "protein_name": "Olfactory receptor 8D1",
        "gene_name": "OR8D1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8D1",
        "refseq_ac": [
            {
                "id": "NP_001002917",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002917",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8D1; OR8D3",
        "gene_names_refseq": "JCG9; OR8D1; OR8D3; OST004; PDJ9J14",
        "protein_names_uniprotkb": "Olfactory receptor 8D1; OST004; Olfactory receptor 8D3; Olfactory receptor OR11-301; Olfactory receptor-like protein JCG9",
        "protein_names_refseq": "olfactory receptor 8D1; olfactory receptor 8D3; olfactory receptor OR11-301; olfactory receptor, family 8, subfamily D, member 3; olfactory receptor-like protein JCG9; olfactory-like receptor JCG9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283159);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 25,
        "publication_id_list": "10460249;11705801;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24714562;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;31040214;31154438;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor (Potential). May be involved in taste perception., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNL4;Q6IEW1;Q8NGH0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q8WZ84-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96R30-1",
        "uniprot_id": [
            {
                "id": "OR2V2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96R30",
                "type": "external"
            }
        ],
        "mass": 35339.0,
        "length": 315,
        "protein_name": "Olfactory receptor 2V2",
        "gene_name": "OR2V2",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2V2",
        "refseq_ac": [
            {
                "id": "NP_996763",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996763",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2V2; OR2V3",
        "gene_names_refseq": "OR2V2; OR2V3; OST713",
        "protein_names_uniprotkb": "Olfactory receptor 2V2; Olfactory receptor 2V3; Olfactory receptor OR5-3",
        "protein_names_refseq": "olfactory receptor 2V2; olfactory receptor 2V3; olfactory receptor OR5-3; olfactory receptor, family 2, subfamily V, member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285659);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 8,
        "publication_id_list": "14983052;24800820;25892735;27515280;29557506;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFL6;Q8NGV1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96R30-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96R69-1",
        "uniprot_id": [
            {
                "id": "OR4F4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96R69",
                "type": "external"
            }
        ],
        "mass": 34259.0,
        "length": 305,
        "protein_name": "Olfactory receptor 4F4",
        "gene_name": "OR4F4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR4F4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 4F4; HS14a-1-A; Olfactory receptor OR19-3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;14983052;24800820;27515280;29557506;31974307;32066986;32157095;32983136;35051231;9384599",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNI5;Q6IFN9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q96R69-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RB7-1",
        "uniprot_id": [
            {
                "id": "OR5MB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RB7",
                "type": "external"
            }
        ],
        "mass": 34450.0,
        "length": 305,
        "protein_name": "Olfactory receptor 5M11",
        "gene_name": "OR5M11",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5M11",
        "refseq_ac": [
            {
                "id": "NP_001005245",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005245",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5M11",
        "gene_names_refseq": "OR11-199; OR5M11",
        "protein_names_uniprotkb": "Olfactory receptor 5M11",
        "protein_names_refseq": "olfactory receptor 5M11; olfactory receptor OR11-199 pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219487);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "24800820;27515280;27893789;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNL5;B2RNL7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q96RB7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UGF6-1",
        "uniprot_id": [
            {
                "id": "OR5V1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UGF6",
                "type": "external"
            }
        ],
        "mass": 36057.0,
        "length": 321,
        "protein_name": "Olfactory receptor 5V1",
        "gene_name": "OR5V1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 5V1",
        "refseq_ac": [
            {
                "id": "NP_110503",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110503",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR5V1",
        "gene_names_refseq": "6M1-21; OR5V1; hs6M1-21",
        "protein_names_uniprotkb": "Olfactory receptor 5V1; Hs6M1-21; Olfactory receptor OR6-26",
        "protein_names_refseq": "olfactory receptor 5V1; olfactory receptor OR6-26",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81696);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "12637542;14983052;17684544;19833159;19851445;20205591;21248752;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[J Infect Dis. 2010 Aug 15;202(3):501], [RefSeq, PubMed, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BDZ0;B0S860;Q5SQI9;Q6NTB5;Q8IVL3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9UGF6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0B4J2A2-1",
        "uniprot_id": [
            {
                "id": "PAL4C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0B4J2A2",
                "type": "external"
            }
        ],
        "mass": 18156.0,
        "length": 164,
        "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4C",
        "gene_name": "PPIAL4C",
        "organism": "Human",
        "refseq_name": "peptidyl-prolyl cis-trans isomerase A-like 4A/B/C",
        "refseq_ac": [
            {
                "id": "NP_001129261",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129261",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPIAL4C",
        "gene_names_refseq": "COAS-2; PPIAL4C",
        "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase A-like 4C; 5.2.1.8; PPIase A-like 4C",
        "protein_names_refseq": "PPIase A-like 4A; PPIase A-like 4C; chromosome 1-amplified sequence 2; chromosome one-amplified sequence 2; cyclophilin homolog overexpressed in liver cancer; peptidyl-prolyl cis-trans isomerase A-like 4A/B/C; peptidylprolyl isomerase A (cyclophilin A)-like 4C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653598)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "10.1101/2023.09.13.557529;29557506",
        "class_list": "",
        "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 9671,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L431;A2BFH1",
        "ec_number_list": [
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0B4J2A2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NFC9-1",
        "uniprot_id": [
            {
                "id": "OR2W5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NFC9",
                "type": "external"
            }
        ],
        "mass": 35528.0,
        "length": 320,
        "protein_name": "Putative olfactory receptor 2W5",
        "gene_name": "OR2W5P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR2W5P; OR2W5",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative olfactory receptor 2W5",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "24800820;27515280;29242379;29786170;31974307;32066986;33592498",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EH85",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "A6NFC9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B3GLJ2-1",
        "uniprot_id": [
            {
                "id": "PATE3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B3GLJ2",
                "type": "external"
            }
        ],
        "mass": 11747.0,
        "length": 98,
        "protein_name": "Prostate and testis expressed protein 3",
        "gene_name": "PATE3",
        "organism": "Human",
        "refseq_name": "prostate and testis expressed protein 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001123355",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123355",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PATE3",
        "gene_names_refseq": "HEL-127; PATE-DJ; PATE3",
        "protein_names_uniprotkb": "Prostate and testis expressed protein 3; Acrosomal vesicle protein HEL-127; PATE-DJ; PATE-like protein DJ",
        "protein_names_refseq": "PATE-like protein DJ; acrosomal vesicle protein HEL-127; prostate and testis expressed protein 3 precursor; prostate and testis expressed protein 3; secreted TFP/Ly-6/uPAR protein PATE-DJ",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100169851)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "18387948;18390568;32350084",
        "class_list": "",
        "function": "Analysis of PATE, expressed primarily in prostate and less in testis, and additional PATE-like genes PATE-M, PATE-DJ, and PATE-B, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5KFZ3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "B3GLJ2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UWI2-1",
        "uniprot_id": [
            {
                "id": "PARM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UWI2",
                "type": "external"
            }
        ],
        "mass": 32289.0,
        "length": 310,
        "protein_name": "Prostate androgen-regulated mucin-like protein 1",
        "gene_name": "PARM1",
        "organism": "Human",
        "refseq_name": "prostate androgen-regulated mucin-like protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_056208",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056208",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PARM1; PRO4322",
        "gene_names_refseq": "Cipar1; DKFZP564O0823; PARM-1; PARM1; WSC4",
        "protein_names_uniprotkb": "Prostate androgen-regulated mucin-like protein 1; PARM-1",
        "protein_names_refseq": "WSC4, cell wall integrity and stress response component 4 homolog; castration-induced prostatic apoptosis-related protein 1; prostate androgen-regulated mucin-like protein 1 precursor; prostatic androgen-regulated mucin-like protein 1; prostatic androgen-repressed message 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25849)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11230166;11237011;12975309;15340161;18027867;19139490;19901323;22766399;23584533;23902727;25502872;25880248;28514659;29242379;31297877;31844290;32357974;33912179;33981976;34357683;35051231;37074911",
        "class_list": "",
        "function": "Ectopic expression of hPARM-1 in PC3 prostate cancer cells increased colony formation, suggesting a probable role in cell proliferation., [RefSeq, PubMed]; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis., [UniProtKB]; Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer., [RefSeq, PubMed]; Our results strongly suggest the oncogenic potential of PARM-1. Publication Status: Online-Only, [RefSeq, PubMed]; PARM1 does not play a major role in the development of epispadias, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMQ9;Q96DV8;Q9Y4S1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005770 late endosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q6UWI2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E9PI22-1",
        "uniprot_id": [
            {
                "id": "P23D1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E9PI22",
                "type": "external"
            }
        ],
        "mass": 31050.0,
        "length": 279,
        "protein_name": "Proline-rich protein 23D1",
        "gene_name": "PRR23D1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PRR23D1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Proline-rich protein 23D1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100131608);  (hsa:100133251)",
        "pathway_count": 2,
        "publication_count": 1,
        "publication_id_list": "32488085",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "E9PI22-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14917-1",
        "uniprot_id": [
            {
                "id": "PCD17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14917",
                "type": "external"
            }
        ],
        "mass": 126229.0,
        "length": 1159,
        "protein_name": "Protocadherin-17",
        "gene_name": "PCDH17",
        "organism": "Human",
        "refseq_name": "protocadherin-17 precursor",
        "refseq_ac": [
            {
                "id": "NP_001035519",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035519",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PCDH17; PCDH68; PCH68",
        "gene_names_refseq": "PCDH17; PCDH68; PCH68",
        "protein_names_uniprotkb": "Protocadherin-17; Protocadherin-68",
        "protein_names_refseq": "protocadherin 68; protocadherin-17 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27253)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17978184;23090970;24190977;28467828;31994011;32357974;32387766;32938616;33896826;33968037;35051231;35580925;36010968;36698136;38145746",
        "class_list": "",
        "function": "MiR-23a-3p promoted G1/S cell cycle transition by targeting protocadherin17 in hepatocellular carcinoma., [RefSeq, PubMed]; PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Potential calcium-dependent cell-adhesion protein., [UniProtKB]; Repression of protocadherin 17 is correlated with elevated angiogenesis and hypoxia markers in female patients with breast cancer., [RefSeq, PubMed]; This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]., [RefSeq]; Ubiquitin ligase NEDD4 promotes the proliferation of hepatocellular carcinoma cells through targeting PCDH17 protein for ubiquitination and degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 101,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1R5;Q5VVW9;Q5VVX0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0099560 synaptic membrane adhesion;GO:1904071 presynaptic active zone assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "O14917-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60829-1",
        "uniprot_id": [
            {
                "id": "PAGE4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60829",
                "type": "external"
            }
        ],
        "mass": 11153.0,
        "length": 102,
        "protein_name": "P antigen family member 4",
        "gene_name": "PAGE4",
        "organism": "Human",
        "refseq_name": "P antigen family member 4",
        "refseq_ac": [
            {
                "id": "NP_001305806",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305806",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAGE4; GAGEC1; JM27",
        "gene_names_refseq": "CT16.7; GAGE-9; GAGEC1; JM-27; JM27; PAGE-1; PAGE-4; PAGE4",
        "protein_names_uniprotkb": "P antigen family member 4; G antigen family C member 1; PAGE-1; PAGE-4",
        "protein_names_refseq": "P antigen family member 4; P antigen family, member 4 (prostate associated); g antigen family C member 1; prostate-associated gene protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9506)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "12489849;15362791;17397028;21357425;22885105;23186163;24263171;24559171;25374899;26242913;27270343;28289210;29758263;30658679;32003504;32698014;35633887;9724777",
        "class_list": "",
        "function": "Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer., [RefSeq, PubMed]; Dysregulation of epithelial PAGE4 modulates AR signaling., [RefSeq, PubMed]; Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function, [RefSeq, PubMed]; PAGE4 mRNA is expressed only in the cytoplasm of epithelial cells of normal and prostate-cancer specimens, [RefSeq, PubMed]; PAGE4 protects PCa cells from DNA damage and apoptosis under oxidative stress by modulating MAPK signalling pathway. PAGE4 expression may serve as a prognostic biomarker for clinical applications. Publication Status: Online-Only, [RefSeq, PubMed]; Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells., [RefSeq, PubMed]; The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that GAGE gene might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior., [RefSeq, PubMed]; This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]; Tissue-Specific Regulation of the Wnt/beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R529;D3DX68;Q6IBI1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0042594 response to starvation;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "O60829-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01298-1",
        "uniprot_id": [
            {
                "id": "PAHO_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01298",
                "type": "external"
            }
        ],
        "mass": 10445.0,
        "length": 95,
        "protein_name": "Pancreatic polypeptide prohormone",
        "gene_name": "PPY",
        "organism": "Human",
        "refseq_name": "pancreatic polypeptide prohormone isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_002713",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002713",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPY; PNP",
        "gene_names_refseq": "PH; PNP; PPY; PP",
        "protein_names_uniprotkb": "Pancreatic polypeptide prohormone; PH; Pancreatic polypeptide Y",
        "protein_names_refseq": "pancreatic polypeptide Y; pancreatic polypeptide prohormone isoform 1 preproprotein; pancreatic polypeptide prohormone; pancreatic prohormone; prepro-PP (prepropancreatic polypeptide)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5539);  (R-HSA-375276);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 122,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10899166;11007482;11237011;11322507;11385580;11457843;11562423;11683476;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;14664712;15139756;15539556;1567413;15947423;15951850;15966750;1655761;16634148;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18577758;22979996;23446738;23690594;24291217;24906252;2534964;2649896;2748346;27496565;2834384;29771765;2997153;3202875;32938616;3366244;33918032;34294685;3525564;36284347;3753985;3856870;514078;6094571;6274691;6281660;6366786;6373251;6589611;7057924;7493937;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;828120;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Fasting human pancreatic polypeptide (HPP) levels are similar in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) and controls regardless of glycemic status., [RefSeq, PubMed]; Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Pancreatic Ppy-expressing gamma-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. Erratum:[Nat Commun. 2021 Sep 27;12(1):5783. doi: 10.1038/s41467-021-26062-9. PMID: 34580307] Publication Status: Online-Only, [RefSeq, PubMed]; These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, peptide yy and pancreatic polypeptide operate both as neural and endocrine messengers--{REVIEW} Review article, [RefSeq, PubMed]; This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]., [RefSeq]; Urinary Dopamine Excretion Rate Decreases during Acute Dietary Protein Deprivation and Is Associated with Increased Plasma Pancreatic Polypeptide Concentration. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0031841 neuropeptide Y receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior;GO:0009306 protein secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "P01298-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C7N1-1",
        "uniprot_id": [
            {
                "id": "OR8U8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7N1",
                "type": "external"
            }
        ],
        "mass": 36334.0,
        "length": 319,
        "protein_name": "Olfactory receptor 8U8",
        "gene_name": "OR8U8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR8U8",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 8U8",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:504189);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "10460249;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;29235485;29557506;31040214;31974307;32066986;35580925",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "P0C7N1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C7T2-1",
        "uniprot_id": [
            {
                "id": "OR2T7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7T2",
                "type": "external"
            }
        ],
        "mass": 34287.0,
        "length": 308,
        "protein_name": "Olfactory receptor 2T7",
        "gene_name": "OR2T7",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR2T7; OR2T7P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 2T7; OST723; olfactory receptor OR1-44",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;32387766",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P0C7T2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0CB38-1",
        "uniprot_id": [
            {
                "id": "PAB4L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0CB38",
                "type": "external"
            }
        ],
        "mass": 41854.0,
        "length": 370,
        "protein_name": "Polyadenylate-binding protein 4-like",
        "gene_name": "PABPC4L",
        "organism": "Human",
        "refseq_name": "polyadenylate-binding protein 4-like",
        "refseq_ac": [
            {
                "id": "NP_001108206",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108206",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PABPC4L",
        "gene_names_refseq": "PABPC4L",
        "protein_names_uniprotkb": "Polyadenylate-binding protein 4-like; PABP-4-like; Poly(A)-binding protein 4-like",
        "protein_names_refseq": "PABP-4-like; polyadenylate-binding protein 4-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:132430)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "26154972;26992070;28218747;29632711;29786170;30429286;30484775;31537871;31844290;35051231;36241641",
        "class_list": "",
        "function": "May bind RNA., [UniProtKB]; Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "P0CB38-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DMB1-1",
        "uniprot_id": [
            {
                "id": "P23D2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DMB1",
                "type": "external"
            }
        ],
        "mass": 31050.0,
        "length": 279,
        "protein_name": "Proline-rich protein 23D2",
        "gene_name": "PRR23D2",
        "organism": "Human",
        "refseq_name": "proline-rich protein 23D2",
        "refseq_ac": [
            {
                "id": "NP_001269407",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269407",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRR23D2",
        "gene_names_refseq": "PRR23D2",
        "protein_names_uniprotkb": "Proline-rich protein 23D2",
        "protein_names_refseq": "proline-rich protein 23C-like; proline-rich protein 23D2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100131608);  (hsa:100133251)",
        "pathway_count": 2,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0DMB1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000001.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23759-3",
        "uniprot_id": [
            {
                "id": "PAX7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23759",
                "type": "external"
            }
        ],
        "mass": 55119.0,
        "length": 505,
        "protein_name": "Paired box protein Pax-7",
        "gene_name": "PAX7",
        "organism": "Human",
        "refseq_name": "paired box protein Pax-7 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001128726",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128726",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAX7; HUP1",
        "gene_names_refseq": "CMYO19; CMYP19; HUP1; MYOSCO; PAX7B; PAX7; RMS2",
        "protein_names_uniprotkb": "Paired box protein Pax-7; HuP1",
        "protein_names_refseq": "PAX7 transcriptional factor; paired box homeotic gene 7; paired box protein Pax-7 isoform 3; paired box protein Pax-7; paired domain gene 7",
        "tax_id": 9606,
        "disease": "congenital myopathy 19 (Disease Ontology:DOID:0081351); prostate cancer (Disease Ontology:DOID:10283); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051)",
        "pathway": " (hsa:5081);  (R-HSA-9834899)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "10393185;16830101;2501086;30379171;31092906;35051231;35082321;35604932;37679820;37685856;37963071;7527137;8187070;8895516;9339373",
        "class_list": "",
        "function": "Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs. Publication Status: Online-Only, [RefSeq, PubMed]; Facioscapulohumeral dystrophy transcriptome signatures correlate with different stages of disease and are marked by different MRI biomarkers. Publication Status: Online-Only, [RefSeq, PubMed]; Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors. Publication Status: Online-Only, [RefSeq, PubMed]; In vitro-generated human muscle reserve cells are heterogeneous for Pax7 with distinct molecular states and metabolic profiles. Publication Status: Online-Only, [RefSeq, PubMed]; PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies through Multiple Signaling Pathways: A Systematic Review. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]., [RefSeq]; Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PFV9;Q0VA99;Q2PJS5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0014816 skeletal muscle satellite cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "P23759-3",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23760-1",
        "uniprot_id": [
            {
                "id": "PAX3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23760",
                "type": "external"
            }
        ],
        "mass": 52968.0,
        "length": 479,
        "protein_name": "Paired box protein Pax-3",
        "gene_name": "PAX3",
        "organism": "Human",
        "refseq_name": "paired box protein Pax-3 isoform PAX3a",
        "refseq_ac": [
            {
                "id": "NP_000429",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000429",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAX3; HUP2",
        "gene_names_refseq": "CDHS; HUP2; PAX-3; PAX3; WS1; WS3",
        "protein_names_uniprotkb": "Paired box protein Pax-3; HuP2",
        "protein_names_refseq": "paired box homeotic gene 3; paired box protein Pax-3 isoform PAX3a; paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; transcriptional factor PAX3",
        "tax_id": 9606,
        "disease": "neural tube defect (Disease Ontology:DOID:0080074); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 3 (Disease Ontology:DOID:0110949); craniofacial-deafness-hand syndrome (Disease Ontology:DOID:0111336); prostate cancer (Disease Ontology:DOID:10283); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); Waardenburg syndrome (Disease Ontology:DOID:9258)",
        "pathway": " (hsa:5077);  (R-HSA-3214847);  (R-HSA-9834899);  (R-HSA-9856649)",
        "pathway_count": 4,
        "publication_count": 104,
        "publication_id_list": "10393185;10567402;10611221;10655586;10673502;10779847;10786633;10821277;11027551;11840323;11891324;11912130;11930005;12949970;1303193;1347148;1347149;14639621;14975237;15118077;15226305;15313887;15507434;16014379;16034366;16387653;16822840;16951170;16971891;1698554;1748288;17623675;18381289;18623064;18644867;19187765;19199574;19524539;19608861;20018852;20460180;20478267;21440083;21486943;21965087;22647378;23058914;23159739;23190890;23207919;23469153;2501086;25248477;25595898;25821947;25880248;27128622;28394346;29152063;29295999;30804224;31844290;32157095;32357974;32636443;33592498;33744299;34140478;37770430;38278051;38372116;38411002;5338216;7545913;7726174;7782066;7825605;7833953;7958932;7981674;8275086;8336698;8447316;8490648;8533800;8589691;8664898;8845842;8863157;8895516;9067759;9199364;9353119;9427644;9440696;9452070;9541113;9558366;9560246;9584079;9676189;9760192;9880483;9973413",
        "class_list": "",
        "function": "Comparative study on the expression of Pax3, Rad51 and VEGF-C in esophageal gastric junction adenocarcinoma and distal gastric adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of PAX3 isoforms in melanocytes and their potential contribution in tumorigenesis in melanoma., [RefSeq, PubMed]; PAX3 mutation suppress otic progenitors proliferation and induce apoptosis by inhibiting WNT1/beta-catenin signaling pathway in WS1 patient iPSC-derived inner ear organoids., [RefSeq, PubMed]; This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087)., [UniProtKB, PubMed, PubMed]; Waardenburg syndrome type 1: a case report of a family with a intragenic PAX3 deletion with no hearing loss or heterochromia of iris., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E9C1;Q16448;Q494Z3;Q494Z4;Q53T90;Q6GSJ9;Q86UQ2;Q86UQ3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P23760-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P39877-1",
        "uniprot_id": [
            {
                "id": "PA2G5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P39877",
                "type": "external"
            }
        ],
        "mass": 15674.0,
        "length": 138,
        "protein_name": "Phospholipase A2 group V",
        "gene_name": "PLA2G5",
        "organism": "Human",
        "refseq_name": "phospholipase A2 group V precursor",
        "refseq_ac": [
            {
                "id": "NP_000920",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000920",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLA2G5",
        "gene_names_refseq": "FRFB; GV-PLA2; PLA2-10; PLA2G5; hVPLA(2)",
        "protein_names_uniprotkb": "Phospholipase A2 group V; 3.1.1.4; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5",
        "protein_names_refseq": "Ca2+-dependent phospholipase A2; calcium-dependent phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; phospholipase A2 group V precursor",
        "tax_id": 9606,
        "disease": "familial benign fleck retina (Disease Ontology:DOID:0111677)",
        "pathway": " (hsa:5322);  (R-HSA-1482788);  (R-HSA-1482801);  (R-HSA-1482839);  (R-HSA-1482922);  (R-HSA-1482925);  (R-HSA-1483166)",
        "pathway_count": 7,
        "publication_count": 106,
        "publication_id_list": "10085124;10092647;10196188;10336645;10358058;10455175;10506173;10553003;10681567;11031251;11112443;11694541;11788596;11830583;12063250;12124392;12150957;12161451;12359733;12522102;12796497;12963729;14573790;14709560;14998370;15367102;15485873;15695510;15863501;15944408;1618844;16243729;16460752;16495223;16617059;16620771;16704971;16818490;16864775;17028579;17101204;17170135;17182612;17707131;18094042;18195019;18238778;18287005;18458083;18614531;18718904;18772128;18781350;19019078;1904318;19336658;19351971;19501189;19554302;19666841;20025994;20705608;21173190;21220512;21515882;22137173;22605381;22777291;22825852;22906437;22922100;23176821;23176823;23533611;23807634;23934110;24715725;24966474;25549071;25725101;26206935;26463208;26503625;26711011;26711221;26715269;28528433;2925608;2925633;31730773;33383652;3458202;7060561;7821823;8083230;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9417066;9461603;9582313;9705332",
        "class_list": "",
        "function": "Data show that phospholipase A2 group IIA, V and X have different target/function related activity., [RefSeq, PubMed]; Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A2. Publication Status: Online-Only, [RefSeq, PubMed]; Low GV-PLA2 expression is associated with cancer., [RefSeq, PubMed]; Lysosome-mediated autophagy pathway contributes to gVPLA2 clearance from lung endothelial cells., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:14998370, PubMed:23533611, PubMed:8300559). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N435",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0032010 phagolysosome",
        "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042130 negative regulation of T cell proliferation;GO:0050482 arachidonate secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "P39877-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q06416-1",
        "uniprot_id": [
            {
                "id": "P5F1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q06416",
                "type": "external"
            }
        ],
        "mass": 38588.0,
        "length": 359,
        "protein_name": "POU domain, class 5, transcription factor 1B",
        "gene_name": "POU5F1B",
        "organism": "Human",
        "refseq_name": "POU domain, class 5, transcription factor 1B",
        "refseq_ac": [
            {
                "id": "NP_001153014",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153014",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POU5F1B; OCT4PG1; OTF3C; OTF3P1; POU5F1P1; POU5FLC20; POU5FLC8",
        "gene_names_refseq": "OCT4-PG1; OCT4PG1; OTF3C; OTF3P1; POU5F1B; POU5F1P1; POU5F1P4; POU5FLC20; POU5FLC8",
        "protein_names_uniprotkb": "POU domain, class 5, transcription factor 1B; Oct4-pg1; Octamer-binding protein 3-like; Octamer-binding transcription factor 3-like",
        "protein_names_refseq": "POU 5 domain protein; POU class 5 homeobox 1 pseudogene 1; POU domain transcription factor OCT4-pg1; POU domain transcription factor Oct-4; POU domain, class 5, transcription factor 1 pseudogene 1; POU domain, class 5, transcription factor 1B; octamer binding protein 3_like sequence",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5462)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "1408763;16201836;16229821;18949397;20017164;21341266;30763293;31271156;34934770;35254053;35987910",
        "class_list": "",
        "function": "POU5F1B was underexpressed in AML compared with controls (P<0.001). The receiver operating characteristic (ROC) curve revealed that the POU5F1B transcript level was able to differentiate AML patients from healthy individuals (AUC=0.682). In non-APL AML patients. Publication Status: Online-Only, [RefSeq, PubMed]; Radiotherapy contributed to the decline in the expression level of POU5F1B in plasma, which was upregulated in ECA109, ECA9706, KYSE410, and KYSE510, but not in HEEPIC. The knockdown of POU5F1B increased the radiosensitivity of esophageal cancer cell lines. Publication Status: Online-Only, [RefSeq, PubMed]; Recurrent Superenhancer of the Oncogene POU5F1B in Colorectal Cancers. Publication Status: Online-Only, [RefSeq, PubMed]; Shows weak transcriptional activator activity., [UniProtKB, PubMed]; That a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1, [RefSeq, PubMed]; This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]., [RefSeq]; Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D5K9S4;D5K9S9;D5K9T0;D5K9T1;D5K9T3;D5K9U3;D5K9U6;D5K9V4;D5K9V6;D5K9W0;D5K9W2;D5K9W7;D5K9X2;D5K9X3;D5K9X5;D5K9X8;D5K9X9;E9LRB1;E9LRB2;E9LRH5;E9LRH6;E9LRH7;E9LRK4;E9LRK5;E9LRK7;E9LRK8;E9LRM7;E9LRM9;E9LRN2;E9LRN4;E9LRN5;E9LRP8;E9LRQ0;E9LRQ2;E9LRQ3;E9LRQ4;E9LRQ5;E9LRS3;Q2VIK6;Q9BZV7;Q9BZV9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q06416-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5JQF8-1",
        "uniprot_id": [
            {
                "id": "PAP1M_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JQF8",
                "type": "external"
            }
        ],
        "mass": 22799.0,
        "length": 200,
        "protein_name": "Polyadenylate-binding protein 1-like 2",
        "gene_name": "PABPC1L2A; PABPC1L2B",
        "organism": "Human",
        "refseq_name": "polyadenylate-binding protein 1-like 2",
        "refseq_ac": [
            {
                "id": "NP_001012995",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012995",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PABPC1L2A; PABPC1L2B; PABPC1L2; RBM32A; RBM32B",
        "gene_names_refseq": "PABPC1L2A; RBM32A",
        "protein_names_uniprotkb": "Polyadenylate-binding protein 1-like 2; RNA-binding motif protein 32; RNA-binding protein 32",
        "protein_names_refseq": "RNA binding motif protein 32A; RNA-binding motif protein 32; RNA-binding protein 32; polyadenylate-binding protein 1-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340529);  (hsa:645974)",
        "pathway_count": 2,
        "publication_count": 1,
        "publication_id_list": "32502341",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMV9;Q8IVU8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q5JQF8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5QFB9-1",
        "uniprot_id": [
            {
                "id": "PAPAS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5QFB9",
                "type": "external"
            }
        ],
        "mass": 12196.0,
        "length": 102,
        "protein_name": "Protein PAPPAS",
        "gene_name": "PAPPA-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PAPPA-AS1; DIPAS; PAPPAS",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein PAPPAS; DIPLA1 antisense RNA 1; DIPLA1 antisense gene protein 1; DIPLA1-antisense expressed; PAPPAS antisense RNA 1; PAPPAS antisense gene protein 1; PAPPAS-antisense expressed",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "15656990",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q5QFB9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IEZ7-1",
        "uniprot_id": [
            {
                "id": "OR2T5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IEZ7",
                "type": "external"
            }
        ],
        "mass": 35595.0,
        "length": 315,
        "protein_name": "Olfactory receptor 2T5",
        "gene_name": "OR2T5",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2T5",
        "refseq_ac": [
            {
                "id": "NP_001004697",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004697",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2T5",
        "gene_names_refseq": "OR1-62; OR2T5",
        "protein_names_uniprotkb": "Olfactory receptor 2T5; Olfactory receptor OR1-62",
        "protein_names_refseq": "olfactory receptor 2T5; olfactory receptor OR1-62",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:401993);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EIN2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6IEZ7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6QHF9-2",
        "uniprot_id": [
            {
                "id": "PAOX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6QHF9",
                "type": "external"
            }
        ],
        "mass": 55513.0,
        "length": 511,
        "protein_name": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase",
        "gene_name": "PAOX",
        "organism": "Human",
        "refseq_name": "peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_690875",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690875",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAOX; PAO; PRO4398",
        "gene_names_refseq": "PAOX; PAO",
        "protein_names_uniprotkb": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; 1.5.3.13; Polyamine oxidase",
        "protein_names_refseq": "peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1; peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase; polyamine oxidase (exo-N4-amino)",
        "tax_id": 9606,
        "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:196743);  (R-HSA-141334);  (R-HSA-351200);  (R-HSA-9033241)",
        "pathway_count": 4,
        "publication_count": 95,
        "publication_id_list": "10022913;10562279;10673331;11101887;11546814;11781871;11931631;12456682;12477380;12559034;12578380;12660232;12717447;12885776;12975309;15545321;15784477;15858711;16207710;16354669;16854980;17007944;17516632;17726030;18359941;18712838;18991276;19197237;19208625;19584060;19632994;1985966;20178365;20405312;21554508;21976670;21980954;22002062;22057399;22371489;22747494;23963456;24235149;24865970;25016021;25538232;25854684;26086376;26138649;26220973;26344566;26547506;27597759;27920218;28228285;28521612;28611990;28765278;28787099;28832583;28834231;28855257;29242379;29393594;30315122;31016788;31154438;31530632;31848261;32157095;32502341;32983136;33298915;33717175;33912179;33968037;34171305;34561969;34932366;35051231;35580925;35886868;7719337;7790377;8360194;8824437;8858165;8991089;9090381;9090382;9090383;9539740;9653144;9668159;9837948",
        "class_list": "",
        "function": "Copy number gain in the polyamine oxidase (PAOX) gene locus was accompanied by a coordinated transcriptional up-regulation in Primary myelofibrosis patients, [RefSeq, PubMed]; Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380)., [UniProtKB, PubMed]; Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients., [RefSeq, PubMed]; PAO activity in children with type 1 diabetes mellitus was very high; higher blood HbA(1C) and MDA levels confirm the presence of oxidant stress demonstrate that PAO activity may participate in these circumstances, [RefSeq, PubMed]; Polyamine Oxidase Expression Is Downregulated by 17beta-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Polyamine oxidase degrades alpha-methylpolyamines in a stereospecific manner, [RefSeq, PubMed]; SSAT and SMO(PAOh1) activities are the major mediators of the cellular response of breast tumor cells to polyamines while PAO plays little or no role in this response, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DXI6;Q5VWY0;Q6QHF5;Q6QHF6;Q6QHF7;Q6QHF8;Q6QHG0;Q6QHG1;Q6QHG2;Q6QHG3;Q6QHG4;Q6QHG5;Q6QHG6;Q86WP9;Q8N555;Q8NCX3",
        "ec_number_list": [
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42",
                "type": "external"
            },
            {
                "id": "1.3.3.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "3.4.24.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56",
                "type": "external"
            },
            {
                "id": "1.4.3.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3",
                "type": "external"
            },
            {
                "id": "2.6.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51",
                "type": "external"
            },
            {
                "id": "2.6.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44",
                "type": "external"
            },
            {
                "id": "2.3.1.176",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "4.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4",
                "type": "external"
            },
            {
                "id": "2.3.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137",
                "type": "external"
            },
            {
                "id": "2.3.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.5.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.4.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.184",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
                "type": "external"
            },
            {
                "id": "1.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38",
                "type": "external"
            },
            {
                "id": "1.3.1.124",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124",
                "type": "external"
            },
            {
                "id": "1.1.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15",
                "type": "external"
            },
            {
                "id": "1.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1",
                "type": "external"
            },
            {
                "id": "1.5.3.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7",
                "type": "external"
            },
            {
                "id": "5.1.99.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4",
                "type": "external"
            },
            {
                "id": "4.1.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63",
                "type": "external"
            },
            {
                "id": "1.2.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046592 polyamine oxidase activity;GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0046203 spermidine catabolic process;GO:0006598 polyamine catabolic process;GO:0009446 putrescine biosynthetic process;GO:0009447 putrescine catabolic process;GO:0046208 spermine catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q6QHF9-2",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6V1P9-1",
        "uniprot_id": [
            {
                "id": "PCD23_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6V1P9",
                "type": "external"
            }
        ],
        "mass": 370228.0,
        "length": 3371,
        "protein_name": "Protocadherin-23",
        "gene_name": "DCHS2",
        "organism": "Human",
        "refseq_name": "protocadherin-23 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001136024",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136024",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DCHS2; CDH27; CDHJ; PCDH23; PCDHJ",
        "gene_names_refseq": "CDH27; CDHJ; CDHR7; DCHS2; PCDH23; PCDHJ",
        "protein_names_uniprotkb": "Protocadherin-23; Cadherin-27; Cadherin-like protein CDHJ; Cadherin-like protein VR8; Protein dachsous homolog 2; Protocadherin PCDHJ",
        "protein_names_refseq": "cadherin J; cadherin-like 27; cadherin-like protein CDHJ; cadherin-like protein VR8; cadherin-related family member 7; protein dachsous homolog 2; protocadherin 23; protocadherin J; protocadherin PCDHJ; protocadherin-23 isoform 2",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:54798)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;15003449;22005931;22960237;25892735;26876984;29769354;30429286;31154438;32938616;33108146;33968037;34171305;34561969;35051231;35318648;35494241;35580925",
        "class_list": "",
        "function": "Calcium-dependent cell-adhesion protein., [UniProtKB]; DCHS2 gene is expressed in the cerebral cortex and thus is a potential candidate for affecting Age of onset in AD., [RefSeq, PubMed]; Findings suggest that the 3 genes, FADS1, FADS2, and DCHS2, containing these SNPs might play dual roles influencing both CSI and ALM in males., [RefSeq, PubMed]; Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017]., [RefSeq]; We found significant differences between the genotype frequency of DCHS2 between controls and amnestic mild cognitive impairment but not between controls and Alzheimers disease., [RefSeq, PubMed]",
        "predicted_glycosites": 23,
        "predicted_n_glycosites": 23,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 90,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 23,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A096LNH0;B2RU14;E9PC11;Q4W5P9;Q6ZS61;Q9NXU8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0048729 tissue morphogenesis;GO:0007409 axonogenesis;GO:0030855 epithelial cell differentiation;GO:0003007 heart morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6V1P9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NG97-1",
        "uniprot_id": [
            {
                "id": "OR2Z1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NG97",
                "type": "external"
            }
        ],
        "mass": 34444.0,
        "length": 314,
        "protein_name": "Olfactory receptor 2Z1",
        "gene_name": "OR2Z1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2Z1",
        "refseq_ac": [
            {
                "id": "NP_001004699",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004699",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2Z1; OR2Z2",
        "gene_names_refseq": "OR19-4; OR2Z1; OR2Z2",
        "protein_names_uniprotkb": "Olfactory receptor 2Z1; Olfactory receptor 2Z2; Olfactory receptor OR19-4",
        "protein_names_refseq": "olfactory receptor 2Z1; olfactory receptor 2Z2; olfactory receptor OR19-4; olfactory receptor, family 2, subfamily Z, member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284383);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231;37586771",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EH50;Q6IFK0;Q96R25",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NG97-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGA2-1",
        "uniprot_id": [
            {
                "id": "OR7A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGA2",
                "type": "external"
            }
        ],
        "mass": 34430.0,
        "length": 310,
        "protein_name": "Putative olfactory receptor 7A2",
        "gene_name": "OR7A2P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR7A2P; OR7A2; OR7A7",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative olfactory receptor 7A2; Putative olfactory receptor 7A7",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "24800820;27515280;31974307;32066986;34087483;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96R95",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NGA2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00329-1",
        "uniprot_id": [
            {
                "id": "PK3CD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00329",
                "type": "external"
            }
        ],
        "mass": 119479.0,
        "length": 1044,
        "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform",
        "gene_name": "PIK3CD",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005017",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005017",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIK3CD",
        "gene_names_refseq": "APDS; IMD14A; IMD14B; IMD14; P110DELTA; PI3Kdelta; PI3K; PIK3CD; ROCHIS; p110D",
        "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; 2.7.1.137; 2.7.1.153; PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta",
        "protein_names_refseq": "PI3-kinase p110 subunit delta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; ptdIns-3-kinase subunit p110-delta",
        "tax_id": 9606,
        "disease": "immunodeficiency 14 (Disease Ontology:DOID:0111936); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); combined immunodeficiency with faciooculoskeletal anomalies (MONDO:MONDO:0013226); immunodeficiency 14b, autosomal recessive (MONDO:MONDO:0023655)",
        "pathway": " (hsa:5293);  (R-HSA-1257604);  (R-HSA-1660499);  (R-HSA-2219530);  (R-HSA-389357);  (R-HSA-512988);  (R-HSA-6811558);  (R-HSA-8853659);  (R-HSA-9027276);  (R-HSA-912526);  (R-HSA-912631);  (R-HSA-9680350);  (R-HSA-983695);  (R-HSA-9856530);  (R-HSA-9927354)",
        "pathway_count": 15,
        "publication_count": 399,
        "publication_id_list": "10051622;10064595;10191262;10194437;10194451;10207047;10224048;10376603;10432293;10448070;10455108;10477686;10477722;10498607;10555148;10556826;10559940;10570274;10593988;10639123;10648173;10649434;10706702;10753883;10764742;10770799;10805725;1081164;10822173;10880360;10949031;10982827;10983984;10995764;11000521;11001876;11002419;11042164;11071869;11084340;11147812;11226282;11237011;11237712;11279162;11302699;11328862;11340297;11349134;11360177;11390647;11449366;11470823;11491658;11598010;11604140;11606584;11676921;11733541;11803464;11853546;11877430;11886862;11901194;11909947;11923287;11968001;12101241;12118066;12138205;12167717;12176338;12181444;12242309;12324459;12422219;12453414;12456653;12506011;12536145;12538664;12573241;12646134;12660731;12670391;12724311;12767043;12771945;12808147;12847086;12881521;12882960;1325671;1334462;1372019;1374290;1375264;1376928;1396555;1400495;14516276;14617813;1465135;14660569;14766744;15007255;15044950;15080793;15107860;15135396;15149544;15161916;15187135;15286081;15304325;15464023;1550550;15509800;15569713;15644415;15716355;15718470;15797027;15834429;15840652;15870016;1599430;16154996;16339315;16399794;16456541;16476736;16522682;16647110;16780920;16849466;16906149;16914545;16979564;17008356;1702217;1702903;1705565;17200115;17202354;17224452;17245604;17290298;17452328;17486119;17626883;17651088;18006696;18025150;18052078;18079394;18093523;18187424;18317450;18326500;1833064;1833065;18374639;18420269;18439422;18467591;18594509;18596693;18606717;18692472;18710921;18753295;18754654;18755892;18818202;18829560;18843204;18925875;18995841;19020623;19038970;19185485;19206206;19249086;19369195;19372136;19411071;19576174;19644473;19665053;19723632;19805105;19896968;19962665;20081091;2011584;20192804;20231295;20338997;20489731;20522708;20534812;2065657;20713702;20940048;21049007;21188471;21204784;21317208;21368164;21408196;21469132;21478295;21668414;21822214;21827948;2196173;21976531;21984976;22020336;22037487;22120714;22153499;22180443;22188813;22210847;22483114;22588880;22647598;22802530;2303036;2304550;23186163;23519112;23758345;24136356;24366607;24714562;24715725;24890514;25495341;2555171;25576301;26029847;26154972;26235028;26811146;2681215;26992070;27566546;27797339;27846572;28904123;29180244;29351928;29437277;29493099;29557506;30040974;30336224;30410026;30429286;31205027;31217245;31844290;32157095;32296767;32350084;32357974;32387766;32488085;32502341;32606397;32897882;32938616;32983136;33141586;33298915;33392160;33717175;33912179;33936100;34185709;34211107;34357683;34499618;34509645;34561969;34932366;3500860;35051231;35154160;35318648;35580925;35863698;36010968;36284347;38363382;38421448;38811189;39253077;40914422;4589993;6335036;7513165;7524079;7528218;7537740;7538118;7592958;7597091;7608176;7624799;7637810;7651724;7665556;7681396;7687428;7687539;7688784;7691807;7737969;7744773;7876172;7927516;8007942;803528;8084588;8163536;8294403;8306975;8355686;8483502;8621607;8626543;8628282;8631863;8637703;8645157;8647804;8649859;8657148;8662982;8663426;8674117;8681945;8700127;8723348;8769125;8947042;8947047;8981370;8995358;9030599;9047384;9094719;9099679;9108392;9111318;9113989;9162089;9192684;9200440;9211928;9225065;9235916;9259313;9286278;9295334;9299438;9326643;9334184;9341187;9367159;9382888;9407096;9422786;9428629;9491986;9514948;9516481;9524259;9525940;9590251;9593664;9620797;9660759;9660833;9685210;9697839;9705962;9736715;9764818;9766809;9811831;9830063;9883723;9885561;9895304",
        "class_list": "",
        "function": "Case report: Deep sequencing and long-read genome sequencing refine prior genetic analyses in families with apparent gonadal mosaicism in PIK3CD-related activated PI3K delta syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; CircZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD., [RefSeq, PubMed]; FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]., [RefSeq]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 13,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NCG0;G1FFP1;O15445;Q5SR49",
        "ec_number_list": [
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.2.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "2.7.1.151",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151",
                "type": "external"
            },
            {
                "id": "2.7.1.140",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140",
                "type": "external"
            },
            {
                "id": "3.1.3.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005942 phosphatidylinositol 3-kinase complex;GO:0005943 phosphatidylinositol 3-kinase complex, class IA",
        "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0006955 immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 40.2,
        "record_id": "O00329-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P15918-1",
        "uniprot_id": [
            {
                "id": "RAG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P15918",
                "type": "external"
            }
        ],
        "mass": 119097.0,
        "length": 1043,
        "protein_name": "V(D)J recombination-activating protein 1",
        "gene_name": "RAG1",
        "organism": "Human",
        "refseq_name": "V(D)J recombination-activating protein 1",
        "refseq_ac": [
            {
                "id": "NP_000439",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000439",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAG1; RNF74",
        "gene_names_refseq": "RAG-1; RAG1; RNF74",
        "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; RAG-1; RING finger protein 74; RING-type E3 ubiquitin transferase RAG1",
        "protein_names_refseq": "RING finger protein 74; V(D)J recombination-activating protein 1; recombination activating gene 1; recombination activating protein 1",
        "tax_id": 9606,
        "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); hypertension (Disease Ontology:DOID:10763); severe combined immunodeficiency (Disease Ontology:DOID:627); combined immunodeficiency due to partial RAG1 deficiency (MONDO:MONDO:0012359)",
        "pathway": " (hsa:5896);  (R-HSA-1266695);  (R-HSA-5687128)",
        "pathway_count": 3,
        "publication_count": 114,
        "publication_id_list": "10470034;10606976;10975528;11133745;11418668;11520796;11564764;11584266;11728342;11804587;12184921;12200379;12546821;12808096;12889071;12915405;14593182;15226418;15353558;15538386;15577943;15749844;16061569;16276422;16360641;16371649;16971392;16973613;17161475;17254968;17395884;17728103;17947239;18031682;18162290;18235225;18248330;18463379;18593949;18644862;18720373;19166925;19473979;19513348;19593530;19864382;19912631;20236090;20536836;20543837;20734105;20849292;20956421;21105711;21177870;21317288;21329875;21329882;21372320;21624848;21771083;22267219;22279049;22464331;22505454;22508986;22800433;23069990;2317865;23878308;24309468;24417533;24585635;24996264;25339975;25516070;25576301;2598259;26301565;26974155;27423467;28216420;28649982;29139090;29242379;29557506;30524438;31154438;31918398;32488085;32502341;32897882;35051231;7489741;7514277;7559638;7719938;7799959;8052633;8107774;8128231;8266077;8702919;8709637;8810255;8844221;9233603;9398404;9535855;9553136;9628874;9630231;9715265;9747882",
        "class_list": "",
        "function": "B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG1 and RAG2 proteins., [RefSeq, PubMed]; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1 (By similarity)., [UniProtKB]; Novel RAG1 mutation in a case of severe combined immunodeficiency. A novel homozygous thymine to cytosine substitution at nucleotide position 2686, [RefSeq, PubMed]; The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PPC4;Q8IY72;Q8NER2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex",
        "go_biological_process": "GO:0006310 DNA recombination;GO:0006955 immune response;GO:0008542 visual learning;GO:0002250 adaptive immune response;GO:0030183 B cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "P15918-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15036-1",
        "uniprot_id": [
            {
                "id": "SNX17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15036",
                "type": "external"
            }
        ],
        "mass": 52901.0,
        "length": 470,
        "protein_name": "Sorting nexin-17",
        "gene_name": "SNX17",
        "organism": "Human",
        "refseq_name": "sorting nexin-17 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001253989",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001253989",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SNX17; KIAA0064",
        "gene_names_refseq": "SNX17",
        "protein_names_uniprotkb": "Sorting nexin-17",
        "protein_names_refseq": "sorting nexin-17 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9784)",
        "pathway_count": 1,
        "publication_count": 111,
        "publication_id_list": "11237011;11237770;12665801;14739284;15121882;15769472;16712798;17322306;18212344;18578522;18669648;19005208;19651622;19664994;19664995;19690332;20058876;20068231;20112406;20166139;21406692;21512128;22492727;23186163;24275569;24366607;24714562;24715725;25418920;25502872;25892735;26154972;26811146;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28352266;28649982;28832583;28834231;28892079;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30524438;30573663;30626607;30779550;30833945;31092671;31154438;31217245;31530632;31671755;31844290;31848261;31998317;32157095;32187731;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33298915;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36215666;36284347;37938771;39587083;40914422",
        "class_list": "",
        "function": "Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Promotion of esophageal adenocarcinoma metastasis via Wnt/ss-catenin signal pathway by sorting nexins 3., [RefSeq, PubMed]; SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQM7;Q53HN7;Q6IAS3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0016197 endosomal transport;GO:0006707 cholesterol catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q15036-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q06945-1",
        "uniprot_id": [
            {
                "id": "SOX4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q06945",
                "type": "external"
            }
        ],
        "mass": 47263.0,
        "length": 474,
        "protein_name": "Transcription factor SOX-4",
        "gene_name": "SOX4",
        "organism": "Human",
        "refseq_name": "transcription factor SOX-4",
        "refseq_ac": [
            {
                "id": "NP_003098",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003098",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SOX4",
        "gene_names_refseq": "CSS10; EVI16; IDDSDF; SOX4",
        "protein_names_uniprotkb": "Transcription factor SOX-4",
        "protein_names_refseq": "SRY (sex determining region Y)-box 4; SRY-box 4; SRY-related HMG-box gene 4; ecotropic viral integration site 16; transcription factor SOX-4",
        "tax_id": 9606,
        "disease": "Coffin-Siris syndrome 10 (Disease Ontology:DOID:0112371); urinary bladder cancer (Disease Ontology:DOID:11054); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:6659);  (R-HSA-3769402)",
        "pathway_count": 2,
        "publication_count": 90,
        "publication_id_list": "10549281;10898789;10921920;10944533;11691915;12408824;12408825;12712206;14600025;14685266;15132997;15327769;15345747;15525529;1614875;16510874;16631117;17218525;17412698;17698607;17875931;18378692;18452278;18456656;18573912;18598779;18819930;19047045;19364920;19590513;19928349;19940019;22304967;23481700;24291232;24715725;25576301;25892735;26024233;26154972;26291311;26375851;26758079;27846572;27920218;28121444;28832583;28834231;29242379;29508533;29769354;29786170;29789417;30429286;30524438;30661772;30779550;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32502341;32897882;32983136;33141586;33592498;33691108;33936100;33968037;34087483;34171305;34211107;34342803;35051231;35580925;36284347;36581221;37938771;38745044;38751373;38842772;38943117;39014441;8268656",
        "class_list": "",
        "function": "ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p. Publication Status: Online-Only, [RefSeq, PubMed]; Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis., [RefSeq, PubMed]; Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA SNHG14 silencing attenuates the progression of diabetic nephropathy via the miR-30e-5p/SOX4 axis., [RefSeq, PubMed]; Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311)., [UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0035198 miRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0002328 pro-B cell differentiation;GO:0060993 kidney morphogenesis;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0021782 glial cell development;GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q06945-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75182-1",
        "uniprot_id": [
            {
                "id": "SIN3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75182",
                "type": "external"
            }
        ],
        "mass": 133066.0,
        "length": 1162,
        "protein_name": "Paired amphipathic helix protein Sin3b",
        "gene_name": "SIN3B",
        "organism": "Human",
        "refseq_name": "paired amphipathic helix protein Sin3b isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001284524",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284524",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SIN3B; KIAA0700",
        "gene_names_refseq": "SIN3B",
        "protein_names_uniprotkb": "Paired amphipathic helix protein Sin3b; Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3b",
        "protein_names_refseq": "SIN3 homolog B, transcriptional regulator; SIN3 transcription regulator homolog B; histone deacetylase complex subunit Sin3b; paired amphipathic helix protein Sin3b isoform 2; paired amphipathic helix protein Sin3b; transcriptional corepressor Sin3b",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:23309);  (R-HSA-427413);  (R-HSA-8936459)",
        "pathway_count": 3,
        "publication_count": 107,
        "publication_id_list": "10.1101/2023.09.13.557529;10471499;10617663;11237011;12483298;12576332;12670868;14610093;16628190;17355984;18316480;18669648;19114653;19509293;19838300;20068231;20339092;20876458;21041482;21129147;21252065;21725049;22777353;23460338;23481700;24366607;24714562;24715725;25418920;25576301;25645385;25892735;25916849;26010396;26154972;26375851;26728094;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30429286;30484775;30517867;30779550;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32467258;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33652591;33717175;33811806;33912179;33936100;33968037;33981976;34171305;34185709;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37137925;37938771;7597036",
        "class_list": "",
        "function": "Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482)., [UniProtKB, UniProtKB, PubMed, PubMed]; Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network., [RefSeq, PubMed]; Establishment of Novel Protein Interaction Assays between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer. Publication Status: Online-Only, [RefSeq, PubMed]; Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder., [RefSeq, PubMed]; Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Publication Status: Online-Only, [RefSeq, PubMed]; These studies identify Sin3B as a transcriptional corepressor associated with the DREAM complex in quiescence., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2NL91;Q68GC2;Q6P4B8;Q8TB34;Q9BSC8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0070822 Sin3-type complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030336 negative regulation of cell migration;GO:0060633 negative regulation of transcription initiation by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "O75182-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15389-1",
        "uniprot_id": [
            {
                "id": "SIGL5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15389",
                "type": "external"
            }
        ],
        "mass": 60715.0,
        "length": 551,
        "protein_name": "Sialic acid-binding Ig-like lectin 5",
        "gene_name": "SIGLEC5",
        "organism": "Human",
        "refseq_name": "sialic acid-binding Ig-like lectin 5 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_003821",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003821",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SIGLEC5; CD33L2; OBBP2",
        "gene_names_refseq": "CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5; SIGLEC5",
        "protein_names_uniprotkb": "Sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; OB-BP2; OB-binding protein 2; Obesity-binding protein 2; Siglec-5",
        "protein_names_refseq": "CD33 antigen-like 2; OB-binding protein 2; obesity-binding protein 2; sialic acid-binding Ig-like lectin 5 isoform 1 precursor; sialic acid-binding immunoglobulin-like lectin 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8778);  (R-HSA-198933);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 128,
        "publication_id_list": "10343116;10428856;10499918;10746781;11231274;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11943481;11955593;11955595;11955599;12213321;12483297;12588680;12763136;14719373;14970179;15034010;15057824;15136729;15155468;15187158;15304001;15489334;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18022638;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;19596804;20730098;21241660;21800138;21841309;21877119;22396535;23090970;23481700;23650620;23695528;23929856;24190977;24305946;24715725;25502872;25703557;25716998;26154972;26284469;26300885;27090790;27846572;27920218;28832583;28871256;28900239;28904123;29242379;29393594;29557506;29632046;30429286;30765789;30922727;31848261;32296183;32350084;32357974;32387766;32983136;33298915;33912179;33936100;34433824;35051231;35154160;35580925;36116391;36129033;36284347;37854605;37890368;7531291;7542404;8178173;8692836;8995416;9285412;9314561;9700512;9730896;9731071",
        "class_list": "glycogene",
        "function": "Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology., [RefSeq, PubMed]; Expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure., [RefSeq, PubMed]; Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival., [RefSeq, PubMed]; PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea. Publication Status: Online-Only, [RefSeq, PubMed]; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface., [UniProtKB]; Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS13., [RefSeq, PubMed]; The prognostic impact of SIGLEC5-induced impairment of CD8[+] T cell activation in sepsis., [RefSeq, PubMed]; This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 764,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 33,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0070821 tertiary granule membrane;GO:0030667 secretory granule membrane;GO:0101003 ficolin-1-rich granule membrane",
        "go_biological_process": "GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 16.7,
        "record_id": "O15389-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P62753-1",
        "uniprot_id": [
            {
                "id": "RS6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P62753",
                "type": "external"
            }
        ],
        "mass": 28681.0,
        "length": 249,
        "protein_name": "Small ribosomal subunit protein eS6",
        "gene_name": "RPS6",
        "organism": "Human",
        "refseq_name": "small ribosomal subunit protein eS6",
        "refseq_ac": [
            {
                "id": "NP_001001",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPS6; SW-cl.2",
        "gene_names_refseq": "RPS6; S6; eS6",
        "protein_names_uniprotkb": "Small ribosomal subunit protein eS6; 40S ribosomal protein S6; Phosphoprotein NP33",
        "protein_names_refseq": "40S ribosomal protein S6; phosphoprotein NP33; small ribosomal subunit protein eS6",
        "tax_id": 9606,
        "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); vascular dementia (Disease Ontology:DOID:8725)",
        "pathway": " (hsa:6194);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-166208);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6790901);  (R-HSA-6791226);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9629569);  (R-HSA-9633012);  (R-HSA-9725371);  (R-HSA-9735869);  (R-HSA-9754678);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 25,
        "publication_count": 434,
        "publication_id_list": "10.1101/2023.09.13.557529;10358005;10364207;10606270;10654941;10659855;1095581;10970870;10982836;11018020;11018027;1104615;11081632;11169414;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11751994;11922599;11935223;11964406;11978965;12068309;12150911;12150926;12417715;12417735;12493757;12554878;12588972;12718880;12742462;12748172;12832468;12853463;1301164;1378441;1400365;1446836;14527413;14567916;14630918;14636577;14742663;14973490;15034551;15199136;15314020;15317934;15385533;15534230;15546618;15676025;15721257;15775988;15781252;15809305;15821744;15956968;16009132;16026328;16037817;16043514;16186820;16209946;16284618;16381836;16452507;16469117;16601204;16622410;16630668;16738141;16782898;16912115;16989641;17053788;17081983;17087515;17110082;17111047;17142313;1715244;17189298;17220279;17267404;17287340;17322306;17352659;17353269;17360704;17363904;1737763;17412707;17416736;17636026;17690253;17726049;17803942;17893241;17922009;17947579;18024471;18065403;18066079;18097461;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18448518;18455985;18524595;18539146;1856229;1856230;18565837;1861871;18657639;18669648;18691976;18767875;18974095;18974281;18991276;19007248;19033376;19060897;19106111;19150429;19332556;19359157;19376132;19417104;19463982;19478851;19503078;19556969;19564402;19574390;19608861;19608919;19648476;19706539;19801658;19819225;19838190;1985906;19859661;19909264;20015877;20023408;20038530;20047967;20056613;2006156;20068231;20112406;20190034;20305658;20361218;20410138;20444697;20460585;20479275;20493732;20531386;20684070;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21060799;21063389;21097556;21145460;21233202;21406692;21418524;21419344;21437771;21602892;21715655;21740066;22028912;22072790;22174690;22190735;22195017;22851697;22855488;22869377;22916032;22929805;22955283;23035226;23085078;23103944;23186163;23217742;23234702;23269699;23303181;23391857;23439679;23481700;23482395;23636399;23643747;23746841;2388630;23974852;24060861;24072592;24086612;24100311;24366607;24424021;24425783;24486019;24524803;24550447;24550462;24550463;24550520;24616378;24714562;24715725;25132172;25242263;25411247;25418920;25432065;25469497;25502872;25505266;25525153;25576301;25653167;25728928;25810538;25818168;25851604;25969445;25993328;26085946;26154972;26196125;26237581;26259639;26375851;26490682;26728094;26758079;26768311;26811146;26992070;27084949;27105488;27452731;27487136;27526673;27553022;27600516;27846572;27920218;28063628;28065601;28132843;28218747;28228285;28247844;2840355;28510447;28603468;28685749;28832583;28834231;28904123;28978054;29207653;29242379;29317506;29393594;29413899;29437277;29487290;29493099;29508533;29557506;29563586;29588546;29632046;29632711;29786170;29914368;29915238;30192525;30293783;30315122;30410026;30429286;30444036;30484775;30524438;30692217;30698812;30779550;30804176;30833945;30902093;31217245;31287628;31366041;31390744;31434245;31530632;31844290;31848261;31998317;32099016;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32522876;32579943;32680882;3279029;32897882;32908316;32938616;32983136;32995776;32995777;33080218;33091337;33149163;33188728;33214551;33268501;33298915;33371356;33392160;33471625;33479166;33592498;33717175;33936100;33968037;33981976;34019948;34171305;34211107;34314702;34315815;34357683;34373319;34509645;34516797;34561969;34624207;34725712;34871442;34932366;35008409;35051231;35083852;35138101;35251023;35318648;35503453;35561310;35580925;36241641;36284347;36302773;36610391;37217939;37572851;37938771;38253038;38665916;39990658;40596516;40914422;40930100;429297;592398;592399;641056;6568109;6688526;6853548;6901506;7000367;7990965;8336711;8407925;8440735;8706699;8890909;8943342;9045610;9211906;9211966;9431993;9482744;9512526;9631292;9637248;9712840;9721431;9732867;9857202;9930702",
        "class_list": "",
        "function": "Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Midkine Promotes Metastasis and Therapeutic Resistance via mTOR/RPS6 in Uveal Melanoma., [RefSeq, PubMed]; Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length., [RefSeq, PubMed]; Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades., [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 29,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P08227;P10660;Q4VBY7;Q8N6Z7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:1903347 negative regulation of bicellular tight junction assembly;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0042593 glucose homeostasis;GO:0071361 cellular response to ethanol",
        "synthesized_glycan_count": 0,
        "hit_score": 43.9,
        "record_id": "P62753-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10301-1",
        "uniprot_id": [
            {
                "id": "RRAS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10301",
                "type": "external"
            }
        ],
        "mass": 23480.0,
        "length": 218,
        "protein_name": "Ras-related protein R-Ras",
        "gene_name": "RRAS",
        "organism": "Human",
        "refseq_name": "ras-related protein R-Ras",
        "refseq_ac": [
            {
                "id": "NP_006261",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006261",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RRAS",
        "gene_names_refseq": "R-Ras; RRAS1; RRAS",
        "protein_names_uniprotkb": "Ras-related protein R-Ras; 3.6.5.2; p23",
        "protein_names_refseq": "oncogene RRAS; p23; ras family small GTP binding protein R-Ras; ras-related protein R-Ras; related RAS viral (r-ras) oncogene homolog",
        "tax_id": 9606,
        "disease": "Costello syndrome (Disease Ontology:DOID:0050469); RASopathy (Disease Ontology:DOID:0080690); urinary bladder cancer (Disease Ontology:DOID:11054)",
        "pathway": " (hsa:6237);  (R-HSA-399955);  (R-HSA-416550)",
        "pathway_count": 3,
        "publication_count": 54,
        "publication_id_list": "10570155;10679438;10934324;11035813;11682467;11937491;12198496;12422220;12730235;15242332;16188938;16286926;16537651;16702230;16773572;16799460;16930978;18025083;18270267;20068231;20074548;24714562;27452731;28228285;28832583;28904123;29242379;29557506;30484775;3098437;31217245;31611695;31844290;32161166;32350084;32502341;32938616;33912179;33968037;34087483;34357683;34405274;34530870;34725712;35051231;35251023;35561310;35580925;36010968;36284347;36960869;38383288;39260747;39809765",
        "class_list": "",
        "function": "GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267)., [UniProtKB, PubMed, PubMed, PubMed]; METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS., [RefSeq, PubMed]; NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras., [RefSeq, PubMed]; R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. Publication Status: Online-Only, [RefSeq, PubMed]; The ancestral type of the R-RAS protein has oncogenic potential. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FH12",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0019003 GDP binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:0007265 Ras protein signal transduction;GO:0060325 face morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "P10301-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZV5-1",
        "uniprot_id": [
            {
                "id": "SELN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZV5",
                "type": "external"
            }
        ],
        "mass": 65813.0,
        "length": 590,
        "protein_name": "Selenoprotein N",
        "gene_name": "SELENON",
        "organism": "Human",
        "refseq_name": "selenoprotein N isoform 2",
        "refseq_ac": [
            {
                "id": "NP_065184",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065184",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELENON; SELN; SEPN1",
        "gene_names_refseq": "CFTD; CMYO3; CMYP3; MDRS1; RSMD1; RSS; SELENON; SELN; SEPN1",
        "protein_names_uniprotkb": "Selenoprotein N; SelN",
        "protein_names_refseq": "selenoprotein N isoform 2; selenoprotein N, 1",
        "tax_id": 9606,
        "disease": "congenital myopathy (Disease Ontology:DOID:0081337); rigid spine muscular dystrophy 1 (Disease Ontology:DOID:0110633)",
        "pathway": " (hsa:57190)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "10.1101/2023.09.13.557529;10608886;11237011;11528383;12192640;12700173;15122708;15668457;16365872;16498447;18713863;19067361;19557870;19769461;21131290;22527882;24190977;25452428;25576301;25645385;26992070;27600516;27645994;27846572;27920218;28218747;28832583;28834231;29237092;29242379;29331515;29393594;29557506;29786170;30429286;30779550;30833945;31154438;31222486;31844290;31848261;32157095;32161166;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33392160;33537174;33592498;33633747;33968037;34087483;34171305;34185709;34509645;35051231;35251023;35318648;35580925;36010968;36215666;36241641;37074911;37938771",
        "class_list": "",
        "function": "Data highlights the importance of the SRE element during SelN expression and illustrates a novel molecular mechanism by which point mutations may lead to SEPN1-related myopathy., [RefSeq, PubMed]; Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290)., [UniProtKB, PubMed]; Identification of this mutation affecting a conserved base in the selenocysteine insertion sequence functional motif thereby reveals the structural basis for a novel pathological mechanism leading to SEPN1-related myopathy, [RefSeq, PubMed]; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863, PubMed:19557870)., [UniProtKB, PubMed, PubMed, PubMed]; The physiological function of SelN in muscle tissue and the pathogenesis leading to SEPN1-related myopathies. [Review] Review article, [RefSeq, PubMed]; This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJG8;A8MQ64;Q6PI70;Q969F6;Q9NUI6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site",
        "go_biological_process": "GO:0048741 skeletal muscle fiber development;GO:1902884 positive regulation of response to oxidative stress;GO:0055074 calcium ion homeostasis;GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity;GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q9NZV5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75326-1",
        "uniprot_id": [
            {
                "id": "SEM7A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75326",
                "type": "external"
            }
        ],
        "mass": 74824.0,
        "length": 666,
        "protein_name": "Semaphorin-7A",
        "gene_name": "SEMA7A",
        "organism": "Human",
        "refseq_name": "semaphorin-7A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001139501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEMA7A; CD108; SEMAL",
        "gene_names_refseq": "CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; PFIC11; SEMA7A; SEMAK1; SEMAL",
        "protein_names_uniprotkb": "Semaphorin-7A; CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Sema K1; Sema L; Semaphorin-K1; Semaphorin-L",
        "protein_names_refseq": "JMH blood group antigen; John Milton Hagen blood group H-Sema K1; john-Milton-Hargen human blood group Ag; sema K1; sema L; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; semaphorin 7A (John Milton Hagen blood group); semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); semaphorin-7A isoform 2; semaphorin-7A; semaphorin-K1; semaphorin-L",
        "tax_id": 9606,
        "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); cholestasis, progressive familial intrahepatic, 11 (MONDO:MONDO:0030815)",
        "pathway": " (hsa:8482);  (R-HSA-416700)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "10.1101/2023.09.13.557529;10201933;10416131;10520995;10648410;11114375;11237011;12193228;12879062;12882840;15218527;15550623;15907379;15944288;16372136;16715077;17207242;17318185;17377534;17671519;20112406;20727575;20854351;21654843;23090970;23481700;24190977;24397554;24714562;25418920;25469497;25502872;25576301;25892735;26154972;26728094;26811146;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28467828;28489076;28649982;28832583;28871256;28904123;29242379;29314611;29391424;29393594;29437277;29557506;29632046;29632711;29769354;29789417;30315122;30410026;30573663;30626607;31154438;31611695;31844290;31848261;31998317;32157095;32265295;32350084;32357974;32983136;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34357683;34433824;34585848;34932366;35051231;35154160;35251023;35580925;36010968;37074911;38665916;38678170;8955171;9712866;9721204",
        "class_list": "",
        "function": "Beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation., [RefSeq, PubMed]; Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Polymorphisms in SEMA7A may play a role in decreased bone mineral density and increased risk of vertebral fracture. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; SEMA 7A might be a molecule involved in the terminal innervation of the dentin-pulp complex., [RefSeq, PubMed]; Sema7A is a potent stimulator of cytokine production, chemotaxis and superoxide release in monocytes, [RefSeq, PubMed]; Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin beta1 in Kawasaki disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DDP7;F5H1S0;Q1XE81;Q1XE82;Q1XE83;Q1XE84;Q3MIY5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0098793 presynapse",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007229 integrin-mediated signaling pathway;GO:0030335 positive regulation of cell migration;GO:0070374 positive regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "O75326-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55060-1",
        "uniprot_id": [
            {
                "id": "XPO2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55060",
                "type": "external"
            }
        ],
        "mass": 110417.0,
        "length": 971,
        "protein_name": "Exportin-2",
        "gene_name": "CSE1L",
        "organism": "Human",
        "refseq_name": "exportin-2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243064",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243064",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CSE1L; CAS; XPO2",
        "gene_names_refseq": "CAS; CSE1L; CSE1; XPO2",
        "protein_names_uniprotkb": "Exportin-2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Exp2; Importin-alpha re-exporter",
        "protein_names_refseq": "BCR/ABL fusion protein; BCR/ABL1 fusion; CSE1 chromosome segregation 1-like; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; epididymis secretory sperm binding protein; exp2; exportin-2 isoform 2; exportin-2; importin-alpha re-exporter",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1434)",
        "pathway_count": 1,
        "publication_count": 131,
        "publication_id_list": "10331944;11703094;14654843;16408927;16959974;18369606;19608861;20068231;20933420;21993680;22223895;22424782;22706990;23186163;23301498;23481700;24275569;24366607;24714562;24715725;25418920;25505266;25576301;25645385;25810538;25880248;25892735;26154972;26375851;26728094;26768311;26992070;27090790;27543614;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29314611;29331515;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30315122;30397120;30410026;30429286;30484775;30524438;30779550;30833945;31092671;31217245;31222486;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34185709;34211107;34357683;34405274;34433824;34509645;34561969;34725712;34932366;35051231;35083852;35138101;35154160;35251023;35318648;35580925;35680799;36010968;36215666;36241641;36284347;36652402;37217939;38241019;38301874;38665916;40914422;7479798;9323134;9786944",
        "class_list": "",
        "function": "DDX27 regulates oral squamous cell carcinoma development through targeting CSE1L., [RefSeq, PubMed]; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus., [UniProtKB, PubMed]; Mechanism of exportin retention in the cell nucleus., [RefSeq, PubMed]; Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]; The role of CSE1L silencing in the regulation of proliferation and apoptosis via the AMPK/mTOR signaling pathway in chronic myeloid leukemia., [RefSeq, PubMed]; [Expression and Clinical Significance of CAS in Acute Myeloid Leukemia Patients]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A3RLL6;B2R5T4;E1P5Y0;F8W904;O75432;Q32M40;Q9H5B7;Q9NTS0;Q9UP98;Q9UP99;Q9UPA0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006611 protein export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "P55060-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRH1-1",
        "uniprot_id": [
            {
                "id": "YAE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRH1",
                "type": "external"
            }
        ],
        "mass": 25299.0,
        "length": 226,
        "protein_name": "Protein YAE1 homolog",
        "gene_name": "YAE1",
        "organism": "Human",
        "refseq_name": "protein YAE1 homolog isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001269375",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269375",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "YAE1; C7orf36; GK003; YAE1D1",
        "gene_names_refseq": "C7orf36; CIAB2; GK003; YAE1D1; YAE1",
        "protein_names_uniprotkb": "Protein YAE1 homolog; Yae1 domain-containing protein 1",
        "protein_names_refseq": "YAE1, ABCE1 maturation factor; Yae1 domain containing 1; protein YAE1 homolog isoform 2; protein YAE1 homolog; yae1 domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57002)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;23301498;23318452;26182403;29557506;30315122;30429286;31217245;31844290;32157095;32983136;33968037;35051231;35580925",
        "class_list": "",
        "function": "The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:26182403)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1W4;B4DE83;Q6IAF7;Q8WVZ5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9NRH1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6W4X9-1",
        "uniprot_id": [
            {
                "id": "MUC6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6W4X9",
                "type": "external"
            }
        ],
        "mass": 257051.0,
        "length": 2439,
        "protein_name": "Mucin-6",
        "gene_name": "MUC6",
        "organism": "Human",
        "refseq_name": "mucin-6 precursor",
        "refseq_ac": [
            {
                "id": "NP_005952",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005952",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC6",
        "gene_names_refseq": "MUC-6; MUC6",
        "protein_names_uniprotkb": "Mucin-6; Gastric mucin-6; MUC-6",
        "protein_names_refseq": "gastric mucin-6; mucin-6 precursor; mucin-6",
        "tax_id": 9606,
        "disease": "gastric ulcer (Disease Ontology:DOID:10808); pancreatic cancer (Disease Ontology:DOID:1793); mucinous adenocarcinoma (Disease Ontology:DOID:3030); cholangiocarcinoma (Disease Ontology:DOID:4947)",
        "pathway": " (hsa:4588);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 84,
        "publication_id_list": "10.1101/2023.09.13.557529;10209489;10330415;10330458;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11606584;11821425;11988092;12464682;12855678;1329093;14656219;15081123;15280409;15466199;15486459;15560372;15599692;15620693;15687324;15979574;16151858;16251947;16319059;17050534;17113861;18490740;18537974;18776906;18818202;19617566;21880719;22041900;22183981;22461326;23053572;23507963;23602766;2373995;24643043;24715725;25153226;26791533;29741879;29786170;31154438;31217245;32157095;32387766;34672134;34808019;35051231;35318648;35353213;35580925;36284347;36367122;37057870;37074911;7655172;7680650;8333853;8598452;8611500;8920913;8972730;9042338;9195947;9295285;9394011;9417100;9422745;9435216;9915862;9988682",
        "class_list": "",
        "function": "Complete genomic (exon/intron) organization, [RefSeq, PubMed]; Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS)., [RefSeq, PubMed]; Glycosylation of MUC6 by alpha1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy., [RefSeq, PubMed]; MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung., [RefSeq, PubMed]; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis., [UniProtKB, PubMed, PubMed, PubMed]; Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors., [RefSeq, PubMed]; Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer., [RefSeq, PubMed]; This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 16,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 14,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 7,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 163,
        "reported_interactions": 0,
        "missing_score": 8621,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 4,
        "glyco_site_count": 23,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15329;Q14394;Q2TUQ5;Q4L207;Q8N8I1;Q8NAK1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q6W4X9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P9B6-1",
        "uniprot_id": [
            {
                "id": "MEAK7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P9B6",
                "type": "external"
            }
        ],
        "mass": 50994.0,
        "length": 456,
        "protein_name": "MTOR-associated protein MEAK7",
        "gene_name": "MEAK7",
        "organism": "Human",
        "refseq_name": "MTOR-associated protein MEAK7",
        "refseq_ac": [
            {
                "id": "NP_065998",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065998",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEAK7; KIAA1609; TLDC1",
        "gene_names_refseq": "EAK7; KIAA1609; MEAK7; TLDC1; mEAK-7",
        "protein_names_uniprotkb": "MTOR-associated protein MEAK7; MEAK7; MTOR associated protein, eak-7 homolog; TBC/LysM-associated domain-containing protein 1; TLD domain-containing protein 1",
        "protein_names_refseq": "MTOR associated protein, eak-7 homolog; MTOR-associated protein MEAK7; TBC/LysM-associated domain containing 1; TBC/LysM-associated domain-containing protein 1; TLD domain containing 1; TLD domain-containing protein 1; mammalian EAK-7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57707)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;20068231;20213681;24223779;26811146;29750193;32350084;32938616;33968037;33981976;34468015;35154160;35251023;35580925;35672408;35994636;36241641;38593795",
        "class_list": "",
        "function": "Activates an alternative mTOR signaling pathway through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). Binds to the vacuolar-type ATPase (V-ATPase) complex, triggering a conformational change and is likely to regulate its activity (PubMed:35672408, PubMed:35994636). No effect on V-ATPase activity was observed in vitro in one study although it was suggested that it may have inhibitory activity in vivo (PubMed:35672408). However, another study showed that it can promote V-ATPase activity (PubMed:38593795). Protects neuronal cells against oxidative stress (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining., [RefSeq, PubMed]; MiR325p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1., [RefSeq, PubMed]; Molecular basis of mEAK7-mediated human V-ATPase regulation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IZ64;Q9HCG3;Q9NTE8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042127 regulation of cell population proliferation;GO:0031667 response to nutrient levels;GO:0032868 response to insulin;GO:0030334 regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6P9B6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VZE5-1",
        "uniprot_id": [
            {
                "id": "NAA35_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VZE5",
                "type": "external"
            }
        ],
        "mass": 83639.0,
        "length": 725,
        "protein_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit",
        "gene_name": "NAA35",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit",
        "refseq_ac": [
            {
                "id": "NP_001308810",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308810",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA35; EGAP; MAK10",
        "gene_names_refseq": "EGAP; MAK10P; MAK10; NAA35; bA379P1.1",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 35, NatC auxiliary subunit; Embryonic growth-associated protein homolog; Protein MAK10 homolog",
        "protein_names_refseq": "MAK10 homolog, amino-acid N-acetyltransferase subunit; N-alpha-acetyltransferase 35, NatC auxiliary subunit; corneal wound healing-related protein; embryonic growth-associated protein homolog; protein MAK10 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:60560);  (R-HSA-6811440)",
        "pathway_count": 2,
        "publication_count": 135,
        "publication_id_list": "10209123;10445031;10559959;10637310;10865125;10990452;11303027;11346801;11359012;11689439;11827983;11839770;12070132;12377769;12620188;12620189;14580338;14718928;15029241;15037235;15077113;15077114;15128430;15269279;15483056;15654769;15758030;15870108;15878329;16042553;16129887;16484612;16571679;16885419;16912714;16936697;17451557;17488291;17562788;17684057;17698061;18195106;18243103;18256213;18367545;18664496;18946081;19164740;19398576;19490898;19620288;19660095;20685960;21183348;21421921;21436057;21689688;21807881;22335553;22354037;22581368;22717455;22898188;23091056;23186163;23437303;23481700;24243830;24714562;24715725;24794632;25343031;25418920;25576301;25645385;26154972;26811146;26992070;27376574;27600516;27846572;27920218;28063628;28228285;28832583;28855257;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30379171;30429286;30745298;31092671;31154438;31530632;31844290;31998317;32157095;32161166;32265295;32357974;32387766;32938616;32983136;33091337;33141586;33298915;33537174;33592498;33936100;33968037;33981976;34405274;34509645;34561969;34932366;35051231;35580925;36010968;37217939;37891180;7909812;8221884;8440258;8620540;8636227;8670882;9050864;9177194;9230071;9590177",
        "class_list": "",
        "function": "A cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia. Erratum:[Nat Med. 2016 Oct 6;22(10):1192. doi: 10.1038/nm1016-1192b. PMID: 27711068], [RefSeq, PubMed]; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Involved in regulation of apoptosis and proliferation of smooth muscle cells (PubMed:19398576)., [UniProtKB, PubMed, PubMed]; Data demonstrate that chimera GOLM1-MAK10 encodes a secreted fusion protein. Mechanistic studies reveal that GOLM1-MAK10 is likely derived from transcription read-through/splicing rather than being generated from a fusion gene., [RefSeq, PubMed]; Human Naa35 (MAK10) is an auxiliary subunit of the human NatC N-terminal acetyltransferase complex. NatC acetylates hydrophobic Met-starting N-termini, and NatC knockdown induces p53-dependent apoptosis., [RefSeq, PubMed]; Salivary exosomal GOLM1-NAA35 chimeric RNA (seG-NchiRNA) constitutes an effective candidate noninvasive biomarker for the convenient, reliable assessment of therapeutic response, recurrence, and early detection., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VZE6;Q9H631;Q9H703",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031417 NatC complex",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0048659 smooth muscle cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.9,
        "record_id": "Q5VZE5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N2H9-1",
        "uniprot_id": [
            {
                "id": "PELI3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N2H9",
                "type": "external"
            }
        ],
        "mass": 50755.0,
        "length": 469,
        "protein_name": "E3 ubiquitin-protein ligase pellino homolog 3",
        "gene_name": "PELI3",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase pellino homolog 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001091980",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091980",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PELI3",
        "gene_names_refseq": "PELI3",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase pellino homolog 3; 2.3.2.27; Pellino-3",
        "protein_names_refseq": "E3 ubiquitin-protein ligase pellino homolog 3 isoform 2; E3 ubiquitin-protein ligase pellino homolog 3; RING-type E3 ubiquitin transferase pellino homolog 3; protein pellino homolog 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:246330);  (R-HSA-9020702);  (R-HSA-937039);  (R-HSA-975144)",
        "pathway_count": 4,
        "publication_count": 82,
        "publication_id_list": "10075690;10514433;10702308;10854325;10882101;10918611;11094434;11237011;11960013;12496252;12538665;12791687;12860405;12874243;14625308;15917247;16547522;16884718;17135271;17141195;17507369;17675297;17890055;17997719;18070982;18180283;1828071;18326498;1833184;18347055;18438411;18724939;19022706;19264966;19903815;2139180;2147937;23186163;24715725;25576301;25645385;26992070;27466718;27600516;27846572;28832583;28834231;29242379;29393594;2946959;29493099;29557506;29605689;29632711;29786170;30315122;30429286;31154438;31520466;31844290;31848261;32157095;32502341;32556677;32635799;32983136;33592498;35051231;35580925;36284347;36861386;7628694;8327496;8332913;8599092;8837778;9346484;9371760;9430229;9859996;9990852;9990853",
        "class_list": "",
        "function": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12874243, PubMed:17675297). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12874243). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 (PubMed:12874243). Can activate AP1/JUN and ELK1 (PubMed:12874243). Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Long Non-coding RNA MIAT Mediates Non-small Cell Lung Cancer Development Through Regulating the miR-128-3p/PELI3 Axis., [RefSeq, PubMed]; MiR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3., [RefSeq, PubMed]; PELI3 gene expression in blood and ovarian cancer., [RefSeq, PubMed]; Pellino3 is a novel upstream regulator of p38 MAPK that activates CREB in a p38-dependent manner, [RefSeq, PubMed]; Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNbeta production., [RefSeq, PubMed]; Suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity [Pellino 3b], [RefSeq, PubMed]; The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N3E1;Q8N9Q6;Q8TAW7;Q8TED5",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0045087 innate immune response;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0070534 protein K63-linked ubiquitination;GO:0008592 regulation of Toll signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q8N2H9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P04054-1",
        "uniprot_id": [
            {
                "id": "PA21B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P04054",
                "type": "external"
            }
        ],
        "mass": 16360.0,
        "length": 148,
        "protein_name": "Phospholipase A2",
        "gene_name": "PLA2G1B",
        "organism": "Human",
        "refseq_name": "phospholipase A2 precursor",
        "refseq_ac": [
            {
                "id": "NP_000919",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000919",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLA2G1B; PLA2A; PLA2; PPLA2",
        "gene_names_refseq": "PLA2A; PLA2G1B; PLA2; PPLA2",
        "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B",
        "protein_names_refseq": "phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2 precursor; phospholipase A2, group IB (pancreas)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5319);  (R-HSA-1482788);  (R-HSA-1482801);  (R-HSA-1482839);  (R-HSA-1482922);  (R-HSA-1482925);  (R-HSA-1483166);  (R-HSA-9925561)",
        "pathway_count": 8,
        "publication_count": 106,
        "publication_id_list": "10085124;10092647;10196188;10336645;10358058;10455175;10506173;10553003;10681567;11031251;11112443;11237011;11788596;11830583;12063250;12150957;12161451;12359733;12522102;12963729;1420353;14573790;14709560;15367102;15485873;15695510;15863501;15944408;1618844;16243729;16460752;16495223;16617059;16620771;16704971;16818490;16864775;17028579;17101204;17170135;17182612;17603006;17707131;18094042;18195019;18238778;18287005;18458083;18614531;18718904;18772128;18781350;19019078;1904318;19297324;19336658;19351971;19501189;19554302;19666841;20025994;20705608;21173190;21220512;21515882;22605381;22777291;22825852;22906437;22922100;23176821;23176823;23807634;23934110;24046806;24966474;25335547;26206935;26463208;26503625;26711011;2925608;2925633;3028739;32436864;32862379;33184968;3458202;35031208;35392090;6349696;7060561;7721806;7821823;8083230;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9417066;9461603;9582313;9705332",
        "class_list": "",
        "function": "Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis., [RefSeq, PubMed]; Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy. Publication Status: Online-Only, [RefSeq, PubMed]; PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients., [RefSeq, PubMed]; SPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy., [RefSeq, PubMed]; SPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1(ser757) signaling pathway., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:10681567, PubMed:1420353, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10681567, PubMed:1420353, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:25335547, PubMed:7721806). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4H5;Q3KPI1",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.2.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.1",
                "type": "external"
            },
            {
                "id": "3.4.21.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.35",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.21.71",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.71",
                "type": "external"
            },
            {
                "id": "3.4.21.70",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.70",
                "type": "external"
            },
            {
                "id": "3.4.17.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1",
                "type": "external"
            },
            {
                "id": "3.4.17.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "3.4.17.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.15",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "2.1.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.20",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.4.21.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.2",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0032052 bile acid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0019731 antibacterial humoral response;GO:0032869 cellular response to insulin stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "P04054-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43914-1",
        "uniprot_id": [
            {
                "id": "TYOBP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43914",
                "type": "external"
            }
        ],
        "mass": 12179.0,
        "length": 113,
        "protein_name": "TYRO protein tyrosine kinase-binding protein",
        "gene_name": "TYROBP",
        "organism": "Human",
        "refseq_name": "TYRO protein tyrosine kinase-binding protein isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001166985",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166985",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TYROBP; DAP12; KARAP",
        "gene_names_refseq": "DAP12; KARAP; PLOSL1; PLOSL; TYROBP",
        "protein_names_uniprotkb": "TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; KAR-associated protein; Killer-activating receptor-associated protein",
        "protein_names_refseq": "DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein isoform 3 precursor; killer-activating receptor-associated protein; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy",
        "tax_id": 9606,
        "disease": "Nasu-Hakola disease (Disease Ontology:DOID:0090112); rheumatoid arthritis (Disease Ontology:DOID:7148)",
        "pathway": " (hsa:7305);  (R-HSA-198933);  (R-HSA-2172127);  (R-HSA-2424491);  (R-HSA-391160);  (R-HSA-416700);  (R-HSA-6798695)",
        "pathway_count": 7,
        "publication_count": 202,
        "publication_id_list": "10021361;10026222;10049942;10072481;10224278;10449773;10469599;10499918;10520995;10572074;10604985;10648410;10744696;10746781;10799849;10811803;10888890;10940905;11048639;11094073;11114375;11237011;11265639;11368773;11390650;11489943;11513152;11556966;11602640;11807247;11857637;11858820;11861603;11907067;11922939;11955593;11955595;11955599;12023008;12213321;12370476;12471105;12483297;12588680;12660731;12668644;12776204;12882840;12911816;14531999;14707061;14719373;14970179;15034010;15136729;15155468;15184383;15187158;15218527;15265913;15294972;15304001;15365099;15383453;15534202;15536084;15541655;15550623;15557162;15580655;15607800;15778510;15781451;15800062;15851719;15864273;15884055;15940674;16014749;16091383;16129954;16213021;16339513;16344560;16380601;16551255;16623599;16715077;16737824;16754721;16893496;16904340;16920917;16928187;16933987;16938345;17012248;17045824;17057721;17070842;17110943;17202323;17237375;17318185;17337780;17369261;17483134;17641029;17928527;18031695;18037897;18055229;18209062;18234675;18593354;18624290;18629938;18657508;18691974;18957693;19149696;19359216;19592130;19592646;19628875;19858347;20093094;20484116;20730098;20865034;20890284;21241660;21659545;21727189;21800138;21841309;21877119;22396535;23650620;23695528;23715743;23719902;2374928;23783831;23929856;24305946;25418920;25703557;25716998;25880248;25957402;25981043;26221034;26284469;26300885;26358190;27452731;27658901;28716534;28904123;29242379;29557506;29789417;31154438;31844290;31848261;32157095;32357974;32387766;32983136;33123756;33392160;33912179;34932366;35051231;35078433;35580925;36181123;36284347;36658241;37117633;38181271;7531291;7542404;8178173;8663278;8692836;8702662;8955171;8986718;8995416;9062191;9285412;9314561;9396765;9490415;9625766;9655483;9690470;9700512;9730896;9830044",
        "class_list": "",
        "function": "Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:10604985, PubMed:9490415, PubMed:9655483). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (PubMed:9490415). Also has an inhibitory role in some cells (PubMed:21727189). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (PubMed:15557162, PubMed:16920917, PubMed:17928527, PubMed:26221034). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (PubMed:10449773). Associates with natural killer (NK) cell receptors such as KIR2DS2 and the KLRD1/KLRC2 heterodimer to mediate NK cell activation (PubMed:23715743, PubMed:9490415, PubMed:9655483). Also enhances trafficking and cell surface expression of NK cell receptors KIR2DS1, KIR2DS2 and KIR2DS4 and ensures their stability at the cell surface (PubMed:23715743). Associates with SIRPB1 to mediate activation of myeloid cells such as monocytes and dendritic cells (PubMed:10604985). Associates with TREM1 to mediate activation of neutrophils and monocytes (PubMed:10799849). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (PubMed:25957402). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (By similarity). Negatively regulates B cell proliferation (PubMed:21727189). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Erratum:[Nat Immunol. 2023 Mar;24(3):558. doi: 10.1038/s41590-023-01465-6. PMID: 36807644], [RefSeq, PubMed]; MMP9 and TYROBP affect the survival of circulating tumor cells in clear cell renal cell carcinoma by adapting to tumor immune microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; TYRO protein tyrosine kinase-binding protein predicts favorable overall survival in osteosarcoma and correlates with antitumor immunity., [RefSeq, PubMed]; TYROBP as a molecular target in cholangiocarcinoma, renal cancer and abdominal aortic aneurysm., [RefSeq, PubMed]; The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2X0;F5H389;Q6FGA5;Q9UMT3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001206 positive regulation of osteoclast development;GO:0032693 negative regulation of interleukin-10 production;GO:0002228 natural killer cell mediated immunity;GO:0002283 neutrophil activation involved in immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 20.3,
        "record_id": "O43914-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q58A45-1",
        "uniprot_id": [
            {
                "id": "PAN3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q58A45",
                "type": "external"
            }
        ],
        "mass": 95613.0,
        "length": 887,
        "protein_name": "PAN2-PAN3 deadenylation complex subunit PAN3",
        "gene_name": "PAN3",
        "organism": "Human",
        "refseq_name": "PAN2-PAN3 deadenylation complex subunit PAN3",
        "refseq_ac": [
            {
                "id": "NP_787050",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787050",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAN3",
        "gene_names_refseq": "PAN3",
        "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3",
        "protein_names_refseq": "PAB-dependent poly(A)-specific ribonuclease subunit 3; PAB-dependent poly(A)-specific ribonuclease subunit PAN3; PAB1P-dependent poly(A)-nuclease; PAB1P-dependent poly(A)-specific ribonuclease; PABP-dependent poly(A) nuclease 3; PABP1-dependent poly A-specific ribonuclease subunit PAN3; PAN deadenylation complex subunit 3; PAN2-PAN3 deadenylation complex subunit PAN3; PAN3 poly(A) specific ribonuclease subunit homolog; poly(A)-nuclease deadenylation complex subunit 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255967);  (R-HSA-429947)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10637334;10882133;11237011;11283721;11889047;1355481;14583602;14749774;15475613;16141059;16284618;17052452;17245413;17595167;18056425;18625844;19239894;19558367;21981923;23186163;23932717;25446091;25480299;25576301;25880248;26992070;27600516;27920218;28559491;28832583;28834231;28904123;29242379;29557506;30429286;30524438;31154438;31401408;31844290;31848261;32157095;32161166;32357974;32387766;32897882;32938616;32983136;33592498;33633747;33912179;33968037;34087483;34105348;34509645;34561969;35051231;35132862;35254053;35580925;36010968;38665916;39534244;39894887;40307207;9099687",
        "class_list": "",
        "function": "Arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA, [RefSeq, PubMed]; Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway. Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD). Its activity is required for efficient P-body formation. May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation., [UniProtKB, UniProtKB, UniProtKB, PubMed]; HPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization, [RefSeq, PubMed]; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins., [UniProtKB, HAMAP, UniProtKB, UniProtKB, PubMed, PubMed]; The present study revealed that circPAN3 is most likely a key modulator for acquired drug resistance of AML, which may facilitate drug resistance in AML cells by regulating autophagy as an autophagy inducer via the AMPK/mTOR pathway. Erratum:[Leuk Res. 2025 Nov;158:108111. doi: 10.1016/j.leukres.2025.108111. PMID: 40992992], [RefSeq, PubMed]; These results reveal a new fundamental step governing mammalian mRNA metabolism. We propose that the first phase of deadenylation, coordinated through the interplay among the two Pan3 isoforms, Pan2, and PABP, represents a cytoplasmic mRNA maturation step important for proper mRNA turnover. Erratum:[RNA. 2018 Nov;24(11):1607-1612. doi: 10.1261/rna.068387.118. PMID: 30327423], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0N0X1;A1A4Y8;A1A4Y9;B1ALF1;B7Z3W7;Q0D2P2;Q5HYG6;Q5T515;Q5T516;Q5TBA0;Q76E13;Q8NBA6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0008143 poly(A) binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0031251 PAN complex",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q58A45-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86WS3-1",
        "uniprot_id": [
            {
                "id": "OOSP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86WS3",
                "type": "external"
            }
        ],
        "mass": 17971.0,
        "length": 158,
        "protein_name": "Oocyte-secreted protein 2",
        "gene_name": "OOSP2",
        "organism": "Human",
        "refseq_name": "oocyte-secreted protein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_776162",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776162",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OOSP2; PLAC1L; TMEM122",
        "gene_names_refseq": "OOSP2A; OOSP2; PLAC1L; TMEM122",
        "protein_names_uniprotkb": "Oocyte-secreted protein 2; Placenta-specific 1-like protein; Protein TMEM122",
        "protein_names_refseq": "oocyte-secreted protein 2 precursor; placenta-specific 1-like protein; testicular tissue protein Li 142; transmembrane protein 122",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219990)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;29557506;29731959;30524438;31429579;35051231;36042231",
        "class_list": "",
        "function": "Involved in oocyte maturation., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PJA4;Q8N9U6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0001556 oocyte maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86WS3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P04085-1",
        "uniprot_id": [
            {
                "id": "PDGFA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P04085",
                "type": "external"
            }
        ],
        "mass": 24043.0,
        "length": 211,
        "protein_name": "Platelet-derived growth factor subunit A",
        "gene_name": "PDGFA",
        "organism": "Human",
        "refseq_name": "platelet-derived growth factor subunit A isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_002598",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002598",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDGFA; PDGF1",
        "gene_names_refseq": "PDGF-A; PDGF1; PDGFA",
        "protein_names_uniprotkb": "Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide",
        "protein_names_refseq": "PDGF A-chain; PDGF subunit A; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A isoform 1 preproprotein",
        "tax_id": 9606,
        "disease": "oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); high grade glioma (Disease Ontology:DOID:3070); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); chronic ulcer of skin (Disease Ontology:DOID:8549)",
        "pathway": " (hsa:5154);  (R-HSA-3000171);  (R-HSA-9818030)",
        "pathway_count": 3,
        "publication_count": 42,
        "publication_id_list": "10358027;11237011;11847221;1317862;1612586;16806867;18483217;19054851;20534510;20628156;22275372;23275004;24463449;24715725;24921206;27588483;27920218;2832727;30524438;31611695;32157095;32897882;32938616;33141586;33298915;33916908;33936100;3422746;35051231;35716012;3614363;3614364;36306470;36608914;3666150;3754619;39295197;39894887;8486521;9038157;9659899;9659900",
        "class_list": "",
        "function": "Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Increased Expression of PDGFA Is Associated With Poor Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma., [RefSeq, PubMed]; Molecular profile and peripheral markers of neurodegeneration in patients with Niemann-Pick type C: Decrease in Plasminogen Activator Inhibitor type 1 and Platelet-Derived Growth Factor type AA., [RefSeq, PubMed]; PDGF-AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia., [RefSeq, PubMed]; PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression., [RefSeq, PubMed]; This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BU73",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005518 collagen binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "P04085-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14108-1",
        "uniprot_id": [
            {
                "id": "SCRB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14108",
                "type": "external"
            }
        ],
        "mass": 54290.0,
        "length": 478,
        "protein_name": "Lysosome membrane protein 2",
        "gene_name": "SCARB2",
        "organism": "Human",
        "refseq_name": "lysosome membrane protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001191184",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191184",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCARB2; CD36L2; LIMP2; LIMPII",
        "gene_names_refseq": "AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SCARB2; SR-BII",
        "protein_names_uniprotkb": "Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; CD36 antigen-like 2; LGP85; LIMP II; Lysosome membrane protein II; Scavenger receptor class B member 2",
        "protein_names_refseq": "85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 2; LIMP II; lysosome membrane protein 2 isoform 2; lysosome membrane protein 2; lysosome membrane protein II",
        "tax_id": 9606,
        "disease": "progressive myoclonus epilepsy 4 (Disease Ontology:DOID:0111444); progressive myoclonus epilepsy (Disease Ontology:DOID:891)",
        "pathway": " (hsa:950);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 3,
        "publication_count": 274,
        "publication_id_list": "10.1101/2023.09.13.557529;10097102;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11231140;11237011;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11840567;11877457;11877461;11889126;11919637;11927540;11988742;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12754519;12847086;12944396;12952949;12958364;1317852;1374238;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15649145;15671180;15703209;15728179;15802264;15895077;15916959;16103228;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;17018281;17035995;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17897319;17978091;18022370;18032517;18093523;18166656;18199683;18308289;18388313;18424452;18452278;1847920;18775314;18790740;18819912;18981233;19092055;19140243;19159218;19287005;19296720;19454373;19458185;19536138;19543282;19575674;19603039;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21670406;21779028;21796727;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23090970;23297414;23536704;23823722;23861397;23891661;24130457;24162852;24186068;24190977;24384571;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;25576301;26042225;26403691;26829388;26992070;27452731;27726376;28218747;28467828;28649982;28855257;28871256;28904123;2890644;29242379;29314611;29437277;29557506;29632711;29671580;29741879;29789417;30429286;30531980;30573663;31154438;32119511;32157095;32350084;32488085;32938616;32983136;33043033;33214551;33298915;33392160;33592498;33912179;33936100;33968037;34019948;34171305;3417785;34357683;34725712;35051231;35154160;35251023;35289036;35580925;36215666;36241641;37074911;37340703;37739936;38231876;38359079;38665916;38914918;40596516;6146630;7509809;7539776;7569928;7822302;7877694;8524399;8552632;8553074;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for enterovirus 71., [UniProtKB, PubMed, PubMed]; Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting., [UniProtKB, PubMed]; Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif., [RefSeq, PubMed]; SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer., [RefSeq, PubMed]; SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 9,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 9,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 9,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 11,
        "reported_phosphosites": 1,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 116,
        "disease_count": 2,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKD8;E7EM68;Q53Y63",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005044 scavenger receptor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0006914 autophagy;GO:0006898 receptor-mediated endocytosis;GO:0006622 protein targeting to lysosome;GO:1904978 regulation of endosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 40.3,
        "record_id": "Q14108-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q969N2-1",
        "uniprot_id": [
            {
                "id": "PIGT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q969N2",
                "type": "external"
            }
        ],
        "mass": 65700.0,
        "length": 578,
        "protein_name": "GPI-anchor transamidase component PIGT",
        "gene_name": "PIGT",
        "organism": "Human",
        "refseq_name": "GPI-anchor transamidase component PIGT isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001171657",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171657",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIGT; CGI-06; PRO1379; PSEC0163",
        "gene_names_refseq": "CGI-06; MCAHS3; NDAP; PIG-T; PIGT; PNH2",
        "protein_names_uniprotkb": "GPI-anchor transamidase component PIGT; Phosphatidylinositol-glycan biosynthesis class T protein",
        "protein_names_refseq": "GPI transamidase component PIG-T; GPI transamidase subunit; GPI-anchor transamidase component PIGT isoform 2 precursor; GPI-anchor transamidase component PIGT; neurotrophin-regulated neuronal development-associated protein; phosphatidylinositol-glycan biosynthesis class T protein",
        "tax_id": 9606,
        "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); multiple congenital anomalies-hypotonia-seizures syndrome 3 (Disease Ontology:DOID:0080140)",
        "pathway": " (hsa:51604);  (R-HSA-162791)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11483512;12582175;12802054;12975309;16303743;19159218;19531498;20068231;22869377;23481700;23636107;23733340;23783831;24190977;24714562;24715725;24906948;25418920;25576301;25645385;25880248;25943031;26154972;26728094;26992070;27600516;27846572;27862975;27916860;28218747;28228285;28327575;28446606;28514659;28728837;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632711;29741879;29786170;29789417;29868109;30315122;30429286;30484775;30779550;30813157;30833945;30976099;31154438;31217245;31222486;31844290;31848261;31998317;32157095;32161166;32220244;32350084;32357974;32387766;32404165;32488085;32502341;32725661;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34046058;34078123;34087483;34162574;34171305;34185709;34211107;34405274;34509645;34561969;34576938;34725712;34932366;35051231;35165458;35251023;35318648;35551457;35561310;35580925;36010968;36177944;36215666;36241641;36284347;36970549;37074911;37684232;37938771;38665916;9356492",
        "class_list": "glycogene",
        "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:11483512, PubMed:12582175, PubMed:28327575, PubMed:34576938, PubMed:35165458, PubMed:35551457, PubMed:36970549, PubMed:37684232). May play a crucial role in GPI-T complex assembly in the luminal layer (PubMed:35165458, PubMed:35551457). Binds GPI-anchor (PubMed:37684232)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GPI8 and PIG-T form a functionally important intermolecular disulfide bridge, [RefSeq, PubMed]; This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 21,
        "reported_glycation": 0,
        "reported_snv": 818,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 16,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RND5;B7Z3N1;B7Z7I8;E1P622;G8JLF5;Q2NL69;Q7Z3N7;Q9BQY7;Q9BQY8;Q9UJG6;Q9Y2Z5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0034235 GPI anchor binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0042765 GPI-anchor transamidase complex",
        "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "Q969N2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000001001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZM6-1",
        "uniprot_id": [
            {
                "id": "PK2L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZM6",
                "type": "external"
            }
        ],
        "mass": 73790.0,
        "length": 624,
        "protein_name": "Polycystin-2-like protein 2",
        "gene_name": "PKD2L2",
        "organism": "Human",
        "refseq_name": "polycystin-2-like protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001245377",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245377",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKD2L2; TRPP5",
        "gene_names_refseq": "PKD2L2; TRPP5",
        "protein_names_uniprotkb": "Polycystin-2-like protein 2; Polycystic kidney disease 2-like 2 protein; Polycystin-2L2; Polycystin-L2",
        "protein_names_refseq": "polycystic kidney disease 2-like 2 protein; polycystin-2-like protein 2 isoform 2; polycystin-2-like protein 2; polycystin-2L2; polycystin-L2; transient receptor potential cation channel subfamily P member 5",
        "tax_id": 9606,
        "disease": "polycystic kidney disease 2 (Disease Ontology:DOID:0110859); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)",
        "pathway": " (hsa:27039)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10602361;10756092;11237011;16883570;25576301;29393594;29557506;29769354;32502341;36284347",
        "class_list": "",
        "function": "Exhibits a lower single conductance but no spontaneous channel activity (PubMed:16883570). May function as a regulator of calcium channels or a channel component involving Ca2(+) homeostasis (By similarity)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NK98;B4DXD2;E9PC91;E9PDG4;Q86YB4;Q9UNJ0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0050982 detection of mechanical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9NZM6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5Y5-1",
        "uniprot_id": [
            {
                "id": "PEX16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5Y5",
                "type": "external"
            }
        ],
        "mass": 38629.0,
        "length": 336,
        "protein_name": "Peroxisomal membrane protein PEX16",
        "gene_name": "PEX16",
        "organism": "Human",
        "refseq_name": "peroxisomal biogenesis factor 16 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004804",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004804",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX16",
        "gene_names_refseq": "PBD8A; PBD8B; PEX16",
        "protein_names_uniprotkb": "Peroxisomal membrane protein PEX16; Peroxin-16; Peroxisomal biogenesis factor 16",
        "protein_names_refseq": "peroxin 16; peroxisomal biogenesis factor 16 isoform 1; peroxisomal membrane protein PEX16; peroxisome biogenesis factor 16",
        "tax_id": 9606,
        "disease": "peroxisome biogenesis disorder 8A (Disease Ontology:DOID:0080483); Peroxisome biogenesis disorder 8B (Disease Ontology:DOID:0081437)",
        "pathway": " (hsa:9409);  (R-HSA-9603798)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "10430017;10704444;11237011;11390669;11402059;11453642;11590176;11883941;12042320;12223482;12751901;12924628;14709540;15007061;15104674;15713480;15781447;16280322;16717127;16791427;16895967;16980692;17069900;18174172;18782765;20068231;20112406;20531392;20554521;20647552;21102411;21768384;21872626;21993680;22624858;22645359;23460677;23481700;23628762;25062251;25418920;25517356;25645385;26375851;26777132;26992070;27846572;27920218;28281558;28325759;28832583;28904123;29242379;29393594;29493099;29508533;29605689;29632046;29632711;30315122;30410026;31844290;31848261;32265295;32357974;32387766;32897882;32938616;32983136;33298915;33633747;33968037;34360754;34932366;35051231;35154160;35580925;9418908;9837814;9922452",
        "class_list": "",
        "function": "Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes. Publication Status: Online-Only, [RefSeq, PubMed]; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BWB9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0007031 peroxisome organization;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0016557 peroxisome membrane biogenesis;GO:0022615 protein to membrane docking",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q9Y5Y5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BWX1-1",
        "uniprot_id": [
            {
                "id": "PHF7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BWX1",
                "type": "external"
            }
        ],
        "mass": 43767.0,
        "length": 381,
        "protein_name": "E3 ubiquitin-protein ligase PHF7",
        "gene_name": "PHF7",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase PHF7 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001265150",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265150",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF7",
        "gene_names_refseq": "HSPC045; HSPC226; NYD-SP6; PHF7",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PHF7; 2.3.2.27; PHD finger protein 7; Testis development protein NYD-SP6",
        "protein_names_refseq": "E3 ubiquitin-protein ligase PHF7 isoform 2; E3 ubiquitin-protein ligase PHF7; testicular secretory protein Li 34; testis development protein NYD-SP6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51533)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;11829468;16959974;22894908;24715725;32726616;32983136",
        "class_list": "",
        "function": "E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (By similarity). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (By similarity). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (By similarity). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (By similarity). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (By similarity). Ubiquitinates histone H4 (PubMed:32726616). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (By similarity)., [UniProtKB, UniProtKB, PubMed]; PHF7 promoter binds H4K12ac in mature spermatozoa., [RefSeq, PubMed]; Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "K4DI82",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140851 histone H3K14 ubiquitin ligase activity;GO:0016740 transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0090291 negative regulation of osteoclast proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q9BWX1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUK5-1",
        "uniprot_id": [
            {
                "id": "PLDX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUK5",
                "type": "external"
            }
        ],
        "mass": 55760.0,
        "length": 500,
        "protein_name": "Plexin domain-containing protein 1",
        "gene_name": "PLXDC1",
        "organism": "Human",
        "refseq_name": "plexin domain-containing protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_065138",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065138",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXDC1; TEM3; TEM7",
        "gene_names_refseq": "PLXDC1; TEM3; TEM7",
        "protein_names_uniprotkb": "Plexin domain-containing protein 1; Tumor endothelial marker 3; Tumor endothelial marker 7",
        "protein_names_refseq": "2410003I07Rik; plexin domain-containing protein 1 precursor; plexin domain-containing protein 1; tumor endothelial marker 3; tumor endothelial marker 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57125)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "10947988;11237011;11559528;15574754;16574105;17560052;18316703;18491316;25326458;29557506;29890852;30414187;30459171;31352222;33592498;33657166;35051231;36213313;36284347;37074911;37453717;39267413",
        "class_list": "",
        "function": "PLXDC1 serves as a potential prognostic marker and involves in malignant progression and macrophage polarization in colon cancer., [RefSeq, PubMed]; PLXDC1 silencing by the HA-CH-NP/siRNA significantly inhibited tumor growth in A2780 tumor-bearing mice., [RefSeq, PubMed]; Plays a critical role in endothelial cell capillary morphogenesis., [UniProtKB]; Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). Publication Status: Online-Only, [RefSeq, PubMed]; Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients, [RefSeq, PubMed]; Study revealed that over-expression of PLXDC1 per se was able to change partly the growth features of U87MG glioblastoma cells. Molecularly, PLXDC1 regulated the epithelial to mesenchymal transition program of tumor cells, whereby its silencing increased the mRNA levels of epithelial transcripts, whereas those of mesenchymal marker genes were reduced., [RefSeq, PubMed]; TEM7 expression level closely parallels histology-based prognostication of OGS metastasis and, therefore, it is a therapeutic target., [RefSeq, PubMed]; TEM7 may play significant role in proliferation and maintenance of neovascular endothelial cells in fibrovascular membranes. TEM7 may be molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7I8;Q5QCZ7;Q5QCZ8;Q5QCZ9;Q9HCT9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0021510 spinal cord development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q8IUK5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P00491-1",
        "uniprot_id": [
            {
                "id": "PNPH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P00491",
                "type": "external"
            }
        ],
        "mass": 32118.0,
        "length": 289,
        "protein_name": "Purine nucleoside phosphorylase",
        "gene_name": "PNP",
        "organism": "Human",
        "refseq_name": "purine nucleoside phosphorylase",
        "refseq_ac": [
            {
                "id": "NP_000261",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000261",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNP; NP",
        "gene_names_refseq": "NP; PNP; PRO1837; PUNP",
        "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase; PNP",
        "protein_names_refseq": "HEL-S-156an; epididymis secretory sperm binding protein Li 156an; inosine phosphorylase; inosine-guanosine phosphorylase; purine nucleoside phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase",
        "tax_id": 9606,
        "disease": "purine nucleoside phosphorylase deficiency (Disease Ontology:DOID:5813); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)",
        "pathway": " (hsa:4860);  (R-HSA-6798695);  (R-HSA-74217);  (R-HSA-74259);  (R-HSA-9735763);  (R-HSA-9755088)",
        "pathway_count": 6,
        "publication_count": 168,
        "publication_id_list": "10075721;10364222;10681516;10766785;11083867;11133996;11237011;11278832;11427893;11690631;12009299;12499231;12606760;12750059;12928150;12947102;1384322;1429593;14706628;15861032;15917509;16265592;16359702;1637327;16446384;17234634;17301077;17405878;17412768;1763067;18399692;18635603;19164483;19470646;20081199;20096989;20112406;20173735;20486858;20504255;2104852;2129526;21396942;2157703;2159925;21755941;218932;22223895;22299025;22509282;227870;23186163;23203137;23301498;23438750;2344353;23650620;24107682;24260472;24957263;25108359;2539852;25418920;25645385;26154972;26375851;26929215;26992070;2737800;27726376;27846572;27920218;280136;28218747;2844225;2845866;28467828;2848805;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29580856;29632046;29632711;29786170;29789417;2999129;30045981;30192525;3029074;30315122;3036115;30429286;30524438;30716294;30779550;30833945;31092671;31154438;31520644;3182793;31844290;31848261;31937595;32144205;32157095;32161166;32350084;32357974;32387766;32502341;32514656;32983136;33043033;33141586;33298915;33392160;33592498;33691108;33936100;33968037;34019948;34185709;34211107;34229054;34357683;34509645;34725712;35051231;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36241641;36538016;36580660;37938771;38431953;38665916;40914422;457664;6087295;6281270;6300847;6771276;8626464;8670112;8692836;8692979;8931706;9305964;9605565;9647364;9804782;9843365;9857047",
        "class_list": "",
        "function": "A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma., [RefSeq, PubMed]; Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase., [RefSeq, PubMed]; Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. Publication Status: Online-Only, [RefSeq, PubMed]; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate., [UniProtKB, UniProtKB]; This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8S5;D3DS00;Q15160;Q5PZ03",
        "ec_number_list": [
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "2.4.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "5.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9",
                "type": "external"
            },
            {
                "id": "5.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-",
                "type": "external"
            },
            {
                "id": "3.4.23.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5",
                "type": "external"
            },
            {
                "id": "3.4.22.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52",
                "type": "external"
            },
            {
                "id": "2.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            },
            {
                "id": "1.13.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34",
                "type": "external"
            },
            {
                "id": "3.3.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6",
                "type": "external"
            },
            {
                "id": "3.4.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "4.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24",
                "type": "external"
            },
            {
                "id": "3.4.19.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1",
                "type": "external"
            },
            {
                "id": "5.3.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1",
                "type": "external"
            },
            {
                "id": "5.3.3.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            },
            {
                "id": "5.4.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11",
                "type": "external"
            },
            {
                "id": "5.4.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "3.5.4.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5",
                "type": "external"
            },
            {
                "id": "5.4.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2",
                "type": "external"
            },
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1",
                "type": "external"
            },
            {
                "id": "2.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.5.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6",
                "type": "external"
            },
            {
                "id": "1.11.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.5.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.109",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.109",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
                "type": "external"
            },
            {
                "id": "2.4.2.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28",
                "type": "external"
            },
            {
                "id": "4.3.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.3.-",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.4.18.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
                "type": "external"
            },
            {
                "id": "4.1.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0042802 identical protein binding;GO:0001882 nucleoside binding;GO:0002060 purine nucleobase binding;GO:0004731 purine-nucleoside phosphorylase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034774 secretory granule lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006955 immune response;GO:0043101 purine-containing compound salvage;GO:0006157 deoxyadenosine catabolic process;GO:0046638 positive regulation of alpha-beta T cell differentiation;GO:0042102 positive regulation of T cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 17.1,
        "record_id": "P00491-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P40967-1",
        "uniprot_id": [
            {
                "id": "PMEL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P40967",
                "type": "external"
            }
        ],
        "mass": 70255.0,
        "length": 661,
        "protein_name": "Melanocyte protein PMEL",
        "gene_name": "PMEL",
        "organism": "Human",
        "refseq_name": "melanocyte protein PMEL isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001186982",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186982",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMEL; D12S53E; PMEL17; SILV",
        "gene_names_refseq": "D12S53E; HMB-45; HMB45; ME20-M; ME20M; ME20; P100; P1; PMEL17; PMEL; SILV; SIL; SI; gp100",
        "protein_names_uniprotkb": "Melanocyte protein PMEL; 95 kDa melanocyte-specific secreted glycoprotein; ME20-M; ME20-S; ME20M; ME20S; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P100; P1; P26; Premelanosome protein; Secreted melanoma-associated ME20 antigen; Silver locus protein homolog",
        "protein_names_refseq": "melanocyte protein PMEL isoform 2 precursor; melanocyte protein Pmel 17; melanocyte protein mel 17; melanocytes lineage-specific antigen GP100; melanoma-associated ME20 antigen; melanosomal matrix protein17; silver locus protein homolog; silver, mouse, homolog of",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6490);  (R-HSA-9824585)",
        "pathway_count": 2,
        "publication_count": 131,
        "publication_id_list": "10540322;10587587;10916751;11237011;11472416;11532965;11684128;11694580;11856727;11886495;11964381;12062444;12643545;12732614;1321344;14632201;15096515;15136590;1537333;1537334;15542798;15543135;15695812;15729346;15814707;15980237;16197958;16303920;16682408;16760433;17056587;17081065;17182843;17952075;17991747;18483280;18483556;18697795;18812475;19047044;1924386;19389701;19717472;19789338;21962903;22869377;23754390;24108701;24267888;24715725;25363716;25645385;25677619;25986168;26171764;26381407;26387950;26451316;26507656;26694611;26792804;26917722;27600516;27821860;27869121;28272432;28904123;29175591;29305520;29314611;29915023;30009548;30135181;30418433;30515787;30524882;30552102;30626607;30764534;30850685;30988362;31092734;31534520;31729751;31844290;31848261;32157095;32241816;32314731;32393905;32488085;32571843;32582212;32594746;32983136;33037893;33100333;33303615;33468649;33665637;33836029;33968037;33990005;34035112;34149689;34207849;34290406;34413169;34769379;35051231;35196075;35580127;35874702;36165170;36215666;37280206;37552474;37586765;38653798;39105816;7519602;7706734;7813420;8022805;8179825;8306979;8592076;8739560;8921401;9647214;9758418",
        "class_list": "",
        "function": "Biogenesis of fibrils requires C-mannosylation of PMEL., [RefSeq, PubMed]; Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins. Publication Status: Online-Only, [RefSeq, PubMed]; GP100 expression is variable in intensity in melanoma. Publication Status: Online-Only, [RefSeq, PubMed]; Pmel17 is proteolytically processed in a post-Golgi compartment and is enriched in multivesicular endosomes prior to incorporation in stage II melanosomes., [RefSeq, PubMed]; Represents a potent melanoma-specific antigen. Among melanoma non-mutated self-peptides, G9-154 (KTWGQYWQV), G9-209 (ITDQVPFSV) and G9-280 (YLEPGPVTA), appear to act as immunodominant common epitopes that stimulate anti-tumor immune response mediated by HLA-A-restricted cytotoxic T cells., [UniProtKB, PubMed, PubMed]; This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]., [RefSeq]; Truncation of the repeat region within Pmel17 alters either fibrillogenic activity or the interaction of Pmel17 with melanin intermediates, [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 56,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KS57;B7Z6D7;Q12763;Q14448;Q14817;Q16565",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "P40967-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NXJ5-1",
        "uniprot_id": [
            {
                "id": "PGPI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NXJ5",
                "type": "external"
            }
        ],
        "mass": 23138.0,
        "length": 209,
        "protein_name": "Pyroglutamyl-peptidase 1",
        "gene_name": "PGPEP1",
        "organism": "Human",
        "refseq_name": "pyroglutamyl-peptidase 1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001295295",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295295",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGPEP1; PGPI",
        "gene_names_refseq": "PAP-I; PGI; PGP-I; PGPEP1; PGPI; PGP; Pcp",
        "protein_names_uniprotkb": "Pyroglutamyl-peptidase 1; 3.4.19.3; 5-oxoprolyl-peptidase; PAP-I; PGP-I; Pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase",
        "protein_names_refseq": "5-oxoprolyl-peptidase; pGlu-peptidase I; pyroglutamyl aminopeptidase I; pyroglutamyl-peptidase 1 isoform 3; pyroglutamyl-peptidase 1; pyrrolidone-carboxylate peptidase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54858)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;12651114;23481700;25687677;25892735;26078706;28218747;28228285;28832583;28834231;28904123;29242379;29437277;29557506;29769354;30429286;31154438;31844290;32157095;32387766;33912179;34816269;37722013",
        "class_list": "",
        "function": "Circ-PGPEP1 augments renal cell carcinoma proliferation, Warburg effect, and distant metastasis., [RefSeq, PubMed]; Cloning and sequencing of the human (AJ278828) pyroglutamyl-peptidase I, [RefSeq, PubMed]; Cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis Publication Status: Online-Only, [RefSeq, PubMed]; Removes 5-oxoproline from various penultimate amino acid residues except L-proline., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]., [RefSeq]; The specific reduction of the levels of pyroglutamyl-aminopeptidase activity in serum of liver cirrhosis patients might be considered as a potential candidate to be included in a combination of markers for the diagnosis of this disease., [RefSeq, PubMed]; Two-photon fluorogenic probe for visualizing PGP-1 activity in inflammatory tissues and serum from patients. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1Q3;Q8IVT1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008233 peptidase activity;GO:0008234 cysteine-type peptidase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9NXJ5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20142-1",
        "uniprot_id": [
            {
                "id": "PEPC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20142",
                "type": "external"
            }
        ],
        "mass": 42426.0,
        "length": 388,
        "protein_name": "Gastricsin",
        "gene_name": "PGC",
        "organism": "Human",
        "refseq_name": "gastricsin isoform 2 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001159896",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159896",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGC",
        "gene_names_refseq": "PEPC; PGC; PGII",
        "protein_names_uniprotkb": "Gastricsin; 3.4.23.3; Pepsinogen C",
        "protein_names_refseq": "gastricsin isoform 2 preproprotein; gastricsin; pepsin C; pepsinogen C; pepsinogen group II; preprogastricsin",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:5225)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;2515193;2567697;2909526;29557506;32983136;3335549;34463892;34817333;34997989;37038800;37938771;6816595;7714902;9406551",
        "class_list": "",
        "function": "Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes a variety of proteins., [UniProtKB]; Medium and large alleles of the PGC gene are risk factors for gastric cancer., [RefSeq, PubMed]; Pepsinogen C expression-related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer., [RefSeq, PubMed]; Pepsinogen II in gastritis and Helicobacter pylori infection. Review article, [RefSeq, PubMed]; This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DVZ3;Q5T3D7;Q5T3D8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion;GO:0002803 positive regulation of antibacterial peptide production",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P20142-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48739-1",
        "uniprot_id": [
            {
                "id": "PIPNB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48739",
                "type": "external"
            }
        ],
        "mass": 31540.0,
        "length": 271,
        "protein_name": "Phosphatidylinositol transfer protein beta isoform",
        "gene_name": "PITPNB",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol transfer protein beta isoform isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001271206",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271206",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PITPNB",
        "gene_names_refseq": "PI-TP-beta; PITPNB; PtdInsTP; VIB1B",
        "protein_names_uniprotkb": "Phosphatidylinositol transfer protein beta isoform; PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta",
        "protein_names_refseq": "PtdIns transfer protein beta; phosphatidylinositol transfer protein beta isoform isoform 2; phosphotidylinositol transfer protein, beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23760);  (R-HSA-1483196)",
        "pathway_count": 2,
        "publication_count": 79,
        "publication_id_list": "10531358;11104777;11237011;11980708;12023904;14962392;15589696;16274224;16780419;18477386;18636990;19608861;20068231;20332109;23481700;24715725;25418920;25576301;25645385;26154972;26992070;27846572;27920218;28218747;28228285;28510447;28832583;28834231;28855257;28860189;28904123;29242379;29437277;29493099;29508533;29557506;29632711;30315122;30484775;30524438;31154438;31530632;31844290;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34509645;34725712;34932366;35051231;35138101;35154160;35580925;36010968;36215666;36241641;38665916;8541325",
        "class_list": "",
        "function": "Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Phosphatidylinositol and phosphatidylcholine exchange activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum., [RefSeq, PubMed]; Role of PITPNB- not required for sphingomyelin trafficking, [RefSeq, PubMed]; The presence of PITPbeta splice variants adds an extra level of proteome complexity, [RefSeq, PubMed]; This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KYB8;B7Z7Q0;Q8N5W1",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0008525 phosphatidylcholine transporter activity;GO:0120019 phosphatidylcholine transfer activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0015914 phospholipid transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006997 nucleus organization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "P48739-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55347-1",
        "uniprot_id": [
            {
                "id": "PKNX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55347",
                "type": "external"
            }
        ],
        "mass": 47607.0,
        "length": 436,
        "protein_name": "Homeobox protein PKNOX1",
        "gene_name": "PKNOX1",
        "organism": "Human",
        "refseq_name": "homeobox protein PKNOX1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004562",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004562",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKNOX1; PREP1",
        "gene_names_refseq": "PKNOX1; PREP1; pkonx1c",
        "protein_names_uniprotkb": "Homeobox protein PKNOX1; Homeobox protein PREP-1; PBX/knotted homeobox 1",
        "protein_names_refseq": "PBX/knotted homeobox 1; Pbx regulating protein-1; homeobox protein PKNOX1 isoform 1; homeobox protein PKNOX1; homeobox protein PREP-1; human homeobox-containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5316);  (R-HSA-5617472)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10777502;11237011;15468914;15867264;16079151;16549775;16959974;17185360;17428788;1756725;17660710;17713478;17761849;17851529;18781158;19115252;19232136;19747919;1975088;19782034;19854132;20085832;22569366;22705304;22879880;23219899;23301498;23534758;23630040;24174538;24275569;24312487;24586203;25101834;25135475;2570724;25913784;29242379;29393594;29508533;29632711;30315122;31839203;31844290;32387766;32502341;33033354;33141586;33968037;35051231;36010968;36356379;37864517;7488013;7501971;7831296;7906964;7908827;8674428;8759021;9143494;9218805;9272954;9479508;9482740",
        "class_list": "",
        "function": "Activates transcription in the presence of PBX1A and HOXA1., [UniProtKB, UniProtKB]; Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis. Publication Status: Online-Only, [RefSeq, PubMed]; PKNOX1 acts as a transcription factor of DHH and promotes the progression of stomach adenocarcinoma by regulating the Hedgehog signalling pathway., [RefSeq, PubMed]; Polyunsaturated fatty acids ameliorate renal stone-induced renal tubular damage via miR-93-5p/Pknox1 axis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00528;Q8IWT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "P55347-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q00169-1",
        "uniprot_id": [
            {
                "id": "PIPNA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q00169",
                "type": "external"
            }
        ],
        "mass": 31806.0,
        "length": 270,
        "protein_name": "Phosphatidylinositol transfer protein alpha isoform",
        "gene_name": "PITPNA",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol transfer protein alpha isoform",
        "refseq_ac": [
            {
                "id": "NP_006215",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006215",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PITPNA; PITPN",
        "gene_names_refseq": "HEL-S-36; PI-TPalpha; PITPNA; PITPN; VIB1A",
        "protein_names_uniprotkb": "Phosphatidylinositol transfer protein alpha isoform; PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha",
        "protein_names_refseq": "PI-TP-alpha; epididymis secretory protein Li 36; phosphatidylinositol transfer protein alpha isoform; ptdIns transfer protein alpha; ptdInsTP alpha",
        "tax_id": 9606,
        "disease": "chylomicron retention disease (Disease Ontology:DOID:0060357)",
        "pathway": " (hsa:5306);  (R-HSA-418890);  (R-HSA-8950505)",
        "pathway_count": 3,
        "publication_count": 61,
        "publication_id_list": "10531358;11237011;14962392;15522822;16038020;17377532;18636990;19608861;22424782;22822086;24715725;25645385;25880248;26154972;26992070;27920218;28218747;28228285;28510447;28649982;28832583;28904123;29104146;29242379;29393594;29557506;29632711;29786170;29789417;30315122;30429286;30573663;30779550;30833945;31154438;31844290;31937595;32157095;32161166;32350084;32357974;32897882;32938616;32983136;33221436;33691108;33912179;33936100;33981976;34019948;34171305;34357683;35051231;35318648;35561310;35580925;36010968;36241641;37460527;37938771;8194769",
        "class_list": "",
        "function": "Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:14962392, PubMed:15522822, PubMed:18636990, PubMed:22822086). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (PubMed:22822086)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that phosphatidylinositol transfer protein alpha (PITPalpha) is involved in the function of mixed lineage kinase domain-like protein (MLKL) in necroptosis., [RefSeq, PubMed]; PDE10A Inhibition Reduces the Manifestation of Pathology in DMD Zebrafish and Represses the Genetic Modifier PITPNA., [RefSeq, PubMed]; Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008289 lipid binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:1901611 phosphatidylglycerol binding;GO:0008526 phosphatidylinositol transfer activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007409 axonogenesis;GO:0007601 visual perception;GO:0015914 phospholipid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q00169-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2B2-1",
        "uniprot_id": [
            {
                "id": "PIGL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2B2",
                "type": "external"
            }
        ],
        "mass": 28531.0,
        "length": 252,
        "protein_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase",
        "gene_name": "PIGL",
        "organism": "Human",
        "refseq_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004269",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004269",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIGL",
        "gene_names_refseq": "CHIME; PIGL",
        "protein_names_uniprotkb": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; 3.5.1.89; PIG-L; Phosphatidylinositol-glycan biosynthesis class L protein",
        "protein_names_refseq": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1; N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; N-acetylglucosaminylphosphatidylinositol deacetylase; PIG-L; phosphatidylinositol glycan, class L; phosphatidylinositol-glycan biosynthesis class L protein",
        "tax_id": 9606,
        "disease": "CHIME syndrome (Disease Ontology:DOID:0112152)",
        "pathway": " (hsa:9487);  (R-HSA-162710)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10069808;10085243;10089216;10944123;11226175;11237011;14517336;14742432;15623507;15632136;15635094;15720390;16162815;22444671;22898188;23481700;25418920;25706356;28327575;28371479;29473937;30315122;3041916;31092671;31844290;31848261;32350084;32502341;32938616;34357683;35051231;35258128;37280393;39641205;7666399;8861954;8893234;8900170;9463366",
        "class_list": "glycogene",
        "function": "C.336-2A>G variant in PIGL associated with developmental disorder resulted in exon skipping., [RefSeq, PubMed]; Catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol., [UniProtKB, PubMed, PubMed]; Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion., [RefSeq, PubMed]; Mutations in PIGL in a patient with Mabry syndrome., [RefSeq, PubMed]; These findings indicate that patients with a clinical diagnosis of CHIME syndrome and a single identifiable mutation in PIGL warrant further investigation for copynumber changes involving, [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]., [RefSeq]; Whole-exome sequencing on five previously reported CHIME cases identified PIGL (N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase) as required for glycosylphosphatidylinositol anchor formation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 331,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA67;B4DYN4",
        "ec_number_list": [
            {
                "id": "3.5.1.89",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.89",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006506 GPI anchor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q9Y2B2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BRJ7-1",
        "uniprot_id": [
            {
                "id": "TIRR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BRJ7",
                "type": "external"
            }
        ],
        "mass": 23338.0,
        "length": 211,
        "protein_name": "Tudor-interacting repair regulator protein",
        "gene_name": "NUDT16L1",
        "organism": "Human",
        "refseq_name": "tudor-interacting repair regulator protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_115725",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115725",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NUDT16L1; SDOS; TIRR",
        "gene_names_refseq": "NUDT16L1; SDOS; TIRR",
        "protein_names_uniprotkb": "Tudor-interacting repair regulator protein; NUDT16-like protein 1; Protein syndesmos",
        "protein_names_refseq": "NUDT16-like protein 1; nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1; protein syndesmos; tudor-interacting repair regulator protein isoform 1; tudor-interacting repair regulator protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84309)",
        "pathway_count": 1,
        "publication_count": 70,
        "publication_id_list": "11237011;18820299;20112406;21070968;22544926;24397554;25418920;25505266;25645385;25880248;26154972;26758079;26811146;26992070;27846572;27862975;27920218;28063628;28213517;28218747;28228285;28241136;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29557506;29632046;29786170;29789417;30315122;30429286;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32897882;32938616;32983136;33141586;33298915;33392160;33717175;33912179;33936100;33961797;33968037;34087483;34211107;34357683;34509645;35051231;35318648;35561310;35580925;36010968;36241641;36284347;37938771",
        "class_list": "",
        "function": "Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299)., [UniProtKB, PubMed, PubMed]; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA., [UniProtKB, UniProtKB]; TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs., [RefSeq, PubMed]; TIRR is a novel 53BP1-interacting protein that participates in the DNA damage response, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NAI2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0030515 snoRNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q9BRJ7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYB4-1",
        "uniprot_id": [
            {
                "id": "PEX5R_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYB4",
                "type": "external"
            }
        ],
        "mass": 69697.0,
        "length": 626,
        "protein_name": "PEX5-related protein",
        "gene_name": "PEX5L",
        "organism": "Human",
        "refseq_name": "PEX5-related protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243679",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243679",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX5L; PEX5R; PXR2",
        "gene_names_refseq": "PEX5L; PEX5RP; PEX5R; PXR2B; PXR2; TRIP8b",
        "protein_names_uniprotkb": "PEX5-related protein; PEX2-related protein; PEX5-like protein; Peroxin-5-related protein; Peroxisome biogenesis factor 5-like; Pex5Rp; TRIP8b; Tetratricopeptide repeat-containing Rab8b-interacting protein",
        "protein_names_refseq": "HCN channel auxiliary subunit; PEX2-related protein; PEX5-like protein; PEX5-related protein isoform 2; PEX5-related protein; Pex5p-related protein; peroxin-5-related protein; peroxisome biogenesis factor 5-like; tetratricopeptide repeat-containing Rab8b-interacting protein",
        "tax_id": 9606,
        "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477)",
        "pathway": " (hsa:51555)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;11463335;16959974;18510355;21504900;25538232;28832583;28864772;28887304;29242379;30192525;31154438;31530632;31848261;35502931",
        "class_list": "",
        "function": "Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence., [UniProtKB, UniProtKB]; Allosteric coupling of the TRIP8b TPR domains both promotes binding to HCN channels and limits binding to type 1 peroxisomal targeting signal substrates., [RefSeq, PubMed]; Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival., [RefSeq, PubMed]; Increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively., [RefSeq, PubMed]; TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels., [RefSeq, PubMed]; The sequential formation of a highly stable trimeric complex involving cargo protein, PEX7 and PEX5L stabilizes cargo binding and is a prerequisite for PTS2-mediated peroxisomal import., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z2A5;B7Z305;B7Z318;B7Z5Z5;B7Z8P2;E7EUV8;E7EUZ0;E9PEC1;E9PH97;Q9NQD1;Q9P2U3;Q9P2U4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0000268 peroxisome targeting sequence binding",
        "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0043235 receptor complex",
        "go_biological_process": "GO:0016560 protein import into peroxisome matrix, docking",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q8IYB4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P15428-1",
        "uniprot_id": [
            {
                "id": "PGDH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P15428",
                "type": "external"
            }
        ],
        "mass": 28977.0,
        "length": 266,
        "protein_name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]",
        "gene_name": "HPGD",
        "organism": "Human",
        "refseq_name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000851",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000851",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HPGD; PGDH1; SDR36C1",
        "gene_names_refseq": "15-PGDH; HPGD; PGDH1; PGDH; PHOAR1; SDR36C1",
        "protein_names_uniprotkb": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 1.1.1.-; 1.1.1.141; 1.1.1.232; 15-PGDH; Eicosanoid/docosanoid dehydrogenase [NAD(+)]; Prostaglandin dehydrogenase 1; Short chain dehydrogenase/reductase family 36C member 1",
        "protein_names_refseq": "15-hydroxyprostaglandin dehydrogenase (NAD(+)); 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; eicosanoid/docosanoid dehydrogenase; hydroxyprostaglandin dehydrogenase 15-(NAD); prostaglandin dehydrogenase 1; short chain dehydrogenase/reductase family 36C member 1",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); primary hypertrophic osteoarthropathy (Disease Ontology:DOID:14283); colon carcinoma (Disease Ontology:DOID:1520); carcinoma (Disease Ontology:DOID:305); prolactinoma (Disease Ontology:DOID:5394); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); isolated congenital digital clubbing (MONDO:MONDO:0007343)",
        "pathway": " (hsa:3248);  (R-HSA-2142700);  (R-HSA-2162123);  (R-HSA-9018676);  (R-HSA-9018896)",
        "pathway_count": 5,
        "publication_count": 102,
        "publication_id_list": "10377455;10622721;10837478;10922363;10966456;11237011;11297515;11465543;11672424;12391014;12627223;12788907;12835322;1380156;14979715;15044627;15047184;15115769;15574495;16475787;16757471;16828555;1697582;17114001;17244615;17449869;17641676;18006499;18292578;18493841;18500342;18682561;18805827;19000823;19865173;20036328;2025296;20667974;20950588;21072165;21206090;21467029;2155925;21916491;22275352;22450811;22844113;23293324;2337593;23438748;23481700;25586183;26743932;27600516;28832583;28980694;29242379;29557506;29789417;30833945;31154438;31844290;32157095;32161166;33303683;33968037;34087483;34171305;34880125;35051231;35580925;3579953;35813463;36010968;36284347;37591693;3770188;3862115;38879084;3954355;4514999;4521806;4776443;5284360;6089195;6422933;7005231;7552725;7557451;7568157;7925341;7947975;8086429;8175750;8250832;8482380;8576264;8901870;9099873;9139685;9219313;9626023",
        "class_list": "",
        "function": "Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:10837478, PubMed:16757471, PubMed:16828555, PubMed:21916491, PubMed:25586183, PubMed:8086429). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:15574495, PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts., [RefSeq, PubMed]; Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma., [RefSeq, PubMed]; Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength., [RefSeq, PubMed]; Reclassification of the HPGD p.Ala13Glu variant causing primary hypertrophic osteoarthropathy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DTA4;B4DU74;B4DV57;D3DP43;E7EV11;O00749;Q06F08;Q12998",
        "ec_number_list": [
            {
                "id": "1.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-",
                "type": "external"
            },
            {
                "id": "1.1.1.141",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.141",
                "type": "external"
            },
            {
                "id": "1.1.1.232",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.232",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0070403 NAD+ binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0004957 prostaglandin E receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:2001301 lipoxin biosynthetic process;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0045471 response to ethanol;GO:0001822 kidney development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P15428-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q0VAA5-1",
        "uniprot_id": [
            {
                "id": "PLCX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q0VAA5",
                "type": "external"
            }
        ],
        "mass": 34777.0,
        "length": 305,
        "protein_name": "PI-PLC X domain-containing protein 2",
        "gene_name": "PLCXD2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PLCXD2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "PI-PLC X domain-containing protein 2; PLCXD-2; Phospholipase C X-domain containing protein 2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:257068)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;17924679;22732399;28063628;29632046;30379171;31844290;32161166;33968037",
        "class_list": "",
        "function": "Catalyzes the hydrolysis of inositol from phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI) (PubMed:22732399). Could also hydrolyze various multi-phosphorylated derivatives of PI, such as phosphatidylinositol-4,5 bisphosphate (PIP2), releasing inositol-1,4,5-trisphosphate (IP3) and the protein kinase C activator diacylglycerol (DAG), therefore mediating cell signaling (Probable)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96N12",
        "ec_number_list": [
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0007165 signal transduction;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q0VAA5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15019-1",
        "uniprot_id": [
            {
                "id": "SEPT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15019",
                "type": "external"
            }
        ],
        "mass": 41487.0,
        "length": 361,
        "protein_name": "Septin-2",
        "gene_name": "SEPTIN2",
        "organism": "Human",
        "refseq_name": "septin-2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001008491",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008491",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEPTIN2; DIFF6; KIAA0158; NEDD5; SEPT2",
        "gene_names_refseq": "DIFF6; NEDD-5; NEDD5; Pnutl3; SEPT2; SEPTIN2; Septin-2; hNedd5",
        "protein_names_uniprotkb": "Septin-2; NEDD-5; Neural precursor cell expressed developmentally down-regulated protein 5",
        "protein_names_refseq": "epididymis secretory sperm binding protein; neural precursor cell expressed, developmentally down-regulated 5; septin-2 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4735);  (R-HSA-5620912)",
        "pathway_count": 2,
        "publication_count": 193,
        "publication_id_list": "11237011;15150837;15592455;15774761;15915442;16093351;16357211;16565220;16857012;16914550;17074750;17081983;17287340;17574030;17637674;17646400;17719545;17803907;17924679;18037885;18083107;18088087;18209106;18212344;18220336;18318008;18452278;18491316;18510355;18578522;18669648;18691976;18694559;18707149;18767875;18801063;19004860;19081074;19145258;19165576;19369195;19413330;19415658;19531498;19562805;19608861;19651622;19664995;19690332;19901323;19940019;20068231;20166139;20230748;20230923;20308558;20399632;20558667;21273506;21406692;21422230;21548880;21565611;21620453;21725307;21792235;21993680;22179047;22424782;22433857;22544926;22645359;22653444;22869377;23141531;23141541;23186163;23253480;23348840;23400999;23481700;23530209;23747070;23769972;23783831;23789104;24053599;24089205;24231678;24275569;24469809;24714562;24715725;24982133;25047611;25313408;25418920;25502872;25505266;25576301;25588830;25645385;25810538;25880248;25892735;26154972;26375851;26728094;26758079;26811146;26992070;27397612;27600516;27846572;27920218;28063628;28218747;28228285;28346465;28514659;28530676;28832583;28834231;28860189;28904123;29242379;29314611;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30524438;31039795;31217245;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34211107;34229054;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35138101;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36738516;37217939;37938771;38665916;8697812",
        "class_list": "",
        "function": "Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis., [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DGE8;Q14132;Q53QU3;Q8IUK9;Q96CB0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization",
        "synthesized_glycan_count": 0,
        "hit_score": 19.6,
        "record_id": "Q15019-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08237-1",
        "uniprot_id": [
            {
                "id": "PFKAM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08237",
                "type": "external"
            }
        ],
        "mass": 85183.0,
        "length": 780,
        "protein_name": "ATP-dependent 6-phosphofructokinase, muscle type",
        "gene_name": "PFKM",
        "organism": "Human",
        "refseq_name": "ATP-dependent 6-phosphofructokinase, muscle type isoform 2",
        "refseq_ac": [
            {
                "id": "NP_000280",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000280",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PFKM; PFKX",
        "gene_names_refseq": "ATP-PFK; GSD7; PFK-1; PFK-A; PFK1; PFKA; PFKM; PFKX; PPP1R122",
        "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, muscle type; 2.7.1.11; 6-phosphofructokinase type A; ATP-PFK; PFK-A; PFK-M; Phosphofructo-1-kinase isozyme A; Phosphohexokinase",
        "protein_names_refseq": "6-phosphofructo-1-kinase; 6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type isoform 2; ATP-dependent 6-phosphofructokinase, muscle type; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase, polypeptide X; phosphofructokinase-M; phosphohexokinase; protein phosphatase 1, regulatory subunit 122",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease VII (Disease Ontology:DOID:11721); glycogen storage disease (Disease Ontology:DOID:2747)",
        "pathway": " (hsa:5213);  (R-HSA-70171)",
        "pathway_count": 2,
        "publication_count": 142,
        "publication_id_list": "10228016;10714828;11237011;11371164;11506403;11780755;12616532;1278465;12965206;13538944;15020257;15710582;16408927;16511037;17287340;17804405;1825608;1833270;183598;1871135;18910716;18910717;18927083;20068231;20112406;2140567;22133655;22219026;22923583;23168256;23186163;23446454;24427140;2462567;24714562;24715725;2526044;2526045;25418920;25576301;25645385;25648650;25880248;26154972;26811146;26929215;26992070;27090790;27846572;2793178;2822475;2846554;28510447;28904123;29242379;29557506;2960695;29775581;30379171;30410026;30429286;30484775;30517626;31092671;31217245;3170585;31844290;3208766;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;3355497;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34509645;3453121;34561969;34725712;34782236;34932366;35051231;35138101;35154160;35251023;3529090;35561310;35580925;36010968;36215666;36241641;36253358;36284347;36601784;37622331;38253038;38665916;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7479776;7513946;7550225;7603526;7717389;7825568;7989588;8037209;8117307;8325892;8447317;8786021;8880699;8889589;9389749;9438414;9443500;9493266",
        "class_list": "glycogene",
        "function": "Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM. Publication Status: Online-Only, [RefSeq, PubMed]; Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity., [RefSeq, PubMed]; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]; Identification of novel PFK-M transcripts in the testis and embryo., [RefSeq, PubMed]; RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells., [RefSeq, PubMed]; Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 859,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J3KNX3;Q16814;Q16815;Q6ZTT1",
        "ec_number_list": [
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0019900 kinase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0097228 sperm principal piece",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046716 muscle cell cellular homeostasis;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "P08237-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H4M7-1",
        "uniprot_id": [
            {
                "id": "PKHA4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H4M7",
                "type": "external"
            }
        ],
        "mass": 85401.0,
        "length": 779,
        "protein_name": "Pleckstrin homology domain-containing family A member 4",
        "gene_name": "PLEKHA4",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family A member 4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001154826",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154826",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHA4; PEPP1",
        "gene_names_refseq": "PEPP1; PLEKHA4",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 4; PEPP-1; PH domain-containing family A member 4; Phosphoinositol 3-phosphate-binding protein 1",
        "protein_names_refseq": "PH domain-containing family A member 4; phosphoinositol 3-phosphate-binding PH domain protein 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; pleckstrin homology domain-containing family A member 4 isoform 2; pleckstrin homology domain-containing family A member 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57664);  (R-HSA-1660499)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10194451;10224048;10555148;10559940;10593988;10753883;10805725;10822173;11001876;11084340;11237011;11279162;11302699;11349134;11604140;11676921;11733541;11877430;11923287;12101241;12118066;12324459;12422219;12536145;12646134;12808147;12847086;14516276;14617813;14660569;15080793;15107860;15135396;15464023;15716355;15797027;15840652;16154996;16399794;16476736;16522682;16914545;16979564;17008356;17245604;17651088;18093523;18753295;19038970;19896968;20534812;21204784;22037487;22647598;23186163;23481700;23519112;23758345;24275569;24715725;25495341;25576301;25645385;27600516;27869121;28228285;29242379;29557506;29786170;30429286;30524438;30568303;31091453;31154438;31530632;31844290;31848261;32157095;32357974;32387766;32938616;33298915;33574086;33592498;33912179;34171305;34405274;34509645;35051231;36010968;36714030;37735118;37980830;7608176;7624799;8681945;8723348;8769125;9094719;9113989;9211928;9286278;9295334;9367159;9428629;9514948;9516481;9524259;9593664;9660759;9660833;9811831;9830063",
        "class_list": "",
        "function": "Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides., [UniProtKB, PubMed]; PLEKHA4 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Glioma. Publication Status: Online-Only, [RefSeq, PubMed]; PLEKHA4 Promotes Wnt/beta-Catenin Signaling-Mediated G1-S Transition and Proliferation in Melanoma., [RefSeq, PubMed]; PLEKHA4 is Associated with Tumour Microenvironment, Stemness, Proliferation and Poor Prognosis of Gliomas., [RefSeq, PubMed]; PLEKHA4 promotes glioblastoma progression through apoptosis inhibition, tumor cell migration, and macrophage infiltration., [RefSeq, PubMed]; PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling., [RefSeq, PubMed]; This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N4M8;Q8N658",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane",
        "go_biological_process": "GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0006661 phosphatidylinositol biosynthetic process;GO:0090263 positive regulation of canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "Q9H4M7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H9J4-1",
        "uniprot_id": [
            {
                "id": "UBP42_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H9J4",
                "type": "external"
            }
        ],
        "mass": 145392.0,
        "length": 1324,
        "protein_name": "Ubiquitin carboxyl-terminal hydrolase 42",
        "gene_name": "USP42",
        "organism": "Human",
        "refseq_name": "ubiquitin carboxyl-terminal hydrolase 42 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_115548",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115548",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "USP42",
        "gene_names_refseq": "USP42",
        "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 42; 3.4.19.12; Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42",
        "protein_names_refseq": "deubiquitinating enzyme 42; ubiquitin carboxyl-terminal hydrolase 42 isoform 2; ubiquitin carboxyl-terminal hydrolase 42; ubiquitin specific protease 42; ubiquitin thioesterase 42; ubiquitin thiolesterase 42; ubiquitin-specific-processing protease 42",
        "tax_id": 9606,
        "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:84132);  (R-HSA-5689880)",
        "pathway_count": 2,
        "publication_count": 88,
        "publication_id_list": "10.1101/2023.09.13.557529;10444327;10982817;11237011;11566882;11923872;12917689;12917691;14661020;14715245;15053880;15916963;16214042;16901786;16964248;17081983;17290220;17443180;17873522;17980597;17981138;18172164;18467330;18632802;18636086;18669648;19015242;19135894;19188362;19363159;19398555;19424180;19690332;19838211;19874889;19910467;20068231;20096447;20228808;20368735;20501646;21239494;21362556;21406692;21571647;21596315;21659512;21849505;21962518;22029577;22085928;22128162;22216260;23159851;23186163;23395819;23481700;23486064;23824326;23825189;24056413;24260525;24275569;24493797;24673627;24896179;25197364;25305019;25578727;26992070;27030989;28904123;31217245;31844290;32387766;32897882;32938310;32938616;33968037;35051231;35779335;36010968;36240223;37217939;38318890;38338801;40596516;7578059",
        "class_list": "",
        "function": "CircUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis., [RefSeq, PubMed]; Deubiquitinating enzyme which may play an important role during spermatogenesis., [UniProtKB]; Investigating USP42 Mutation as Underlying Cause of Familial Non-Medullary Thyroid Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia., [RefSeq, PubMed]; The function of USP42 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent cell-cycle arrest in response to stress. Publication Status: Online-Only, [RefSeq, PubMed]; USP42 overexpression could be a potential prognostic marker for GC, regulate the survival and invasive properties of GC, and may represent a novel therapeutic molecular target for this tumor. Publication Status: Online-Only, [RefSeq, PubMed]; We report, for the first time, the identification of a RUNX1-USP42 fusion transcript detected at diagnosis in a child with AML and del(5). Review article, [RefSeq, PubMed]; [Ubiquitin-specific protease 42 regulates osteogenic differentiation of human adipose-derived stem cells]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUE3;B5MDA5;Q0VIN8;Q3C166;Q6P9B4",
        "ec_number_list": [
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0016579 protein deubiquitination;GO:0030154 cell differentiation;GO:0031647 regulation of protein stability",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q9H9J4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92871-1",
        "uniprot_id": [
            {
                "id": "PMM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92871",
                "type": "external"
            }
        ],
        "mass": 29747.0,
        "length": 262,
        "protein_name": "Phosphomannomutase 1",
        "gene_name": "PMM1",
        "organism": "Human",
        "refseq_name": "phosphomannomutase 1",
        "refseq_ac": [
            {
                "id": "NP_002667",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002667",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMM1; PMMH22",
        "gene_names_refseq": "PMM 1; PMM1; PMMH-22; Sec53",
        "protein_names_uniprotkb": "Phosphomannomutase 1; 5.4.2.8; PMM 1; PMMH-22",
        "protein_names_refseq": "brain glucose-1,6-bisphosphatase; phosphomannomutase 1",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552)",
        "pathway": " (hsa:5372);  (R-HSA-446205)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "10980531;11082198;11237011;16540464;18477386;18591914;18927083;23481700;24035193;24366607;24715725;24958902;25576301;26375851;26992070;27600516;27846572;27869121;27920218;28228285;28832583;28904123;29242379;29261720;29331515;29393594;29557506;29695157;29789417;30315122;30429286;30484775;30779550;30833945;31154438;31222486;31530632;31844290;32157095;32488085;32938616;33592498;33691108;33717175;33912179;33936100;33968037;33981976;33986552;34171305;34211107;34561969;34932366;35051231;35318648;35580925;36215666;36241641;37938771;5946626;8307007;9070917;9119384;9140401",
        "class_list": "glycogene",
        "function": "A triple mutant of phospomannomutase1 that retains mutase and phosphatase activity, but is unable to bind inosine monophosphate, was characterized. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain., [UniProtKB, PubMed]; PMM1 is responsible for the degradation of Glc-1,6-P(2) in brain, [RefSeq, PubMed]; Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008]., [RefSeq]; The 1.93 A resolution structure of PMM1 complexed with inosine monophosphate (IMP) was determined. The structure reveals IMP bound at the substrate recruitment site, thus inhibiting the mutase activity while simultaneously activating a phosphatase activity (IMP Kact = 1.5 muM) resulting from the hydrolysis of the phospho-enzyme., [RefSeq, PubMed]; The genes GUS and PMM1 are recommended for normalization purposes in gene expression studies of liver tissue from patients with chronic hepatitis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 321,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K003;Q92586",
        "ec_number_list": [
            {
                "id": "5.4.2.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.8",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004615 phosphomannomutase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q92871-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O94903-1",
        "uniprot_id": [
            {
                "id": "PLPHP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O94903",
                "type": "external"
            }
        ],
        "mass": 30344.0,
        "length": 275,
        "protein_name": "Pyridoxal phosphate homeostasis protein",
        "gene_name": "PLPBP",
        "organism": "Human",
        "refseq_name": "pyridoxal phosphate homeostasis protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_009129",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009129",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLPBP; PROSC",
        "gene_names_refseq": "EPEO1; EPVB6D; PLPBP; PROSC",
        "protein_names_uniprotkb": "Pyridoxal phosphate homeostasis protein; PLP homeostasis protein; Proline synthase co-transcribed bacterial homolog protein; Pyridoxal phosphate-binding protein",
        "protein_names_refseq": "PLP homeostasis protein; proline synthase co-transcribed bacterial homolog protein; proline synthetase co-transcribed bacterial homolog protein; pyridoxal phosphate homeostasis protein isoform 2; pyridoxal phosphate homeostasis protein",
        "tax_id": 9606,
        "disease": "early-onset vitamin B6-dependent epilepsy 1 (Disease Ontology:DOID:0080769)",
        "pathway": " (hsa:11212)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "10496079;11230166;11237011;20166139;22544926;23186163;23301498;23481700;24275569;24715725;25505266;25576301;25645385;26154972;26375851;26992070;27846572;27912044;27920218;28228285;28391250;28832583;28904123;28914444;29493099;29508533;29557506;29786170;30315122;30410026;31154438;31844290;31998317;32157095;32161166;32897882;32938616;32983136;33141586;33936100;33981976;34019948;34229054;35051231;35318648;35561310;35580925;37451483;40914422",
        "class_list": "",
        "function": "Exploiting the universality of the Synechococcus elongatus COG0325 (PiPY) functions, it has been used in site-directed mutagenesis studies to shed light on disease causation by epilepsy-associated mutations in the human COG0325 gene PROSC., [RefSeq, PubMed]; Maintenance of cellular vitamin B6 levels and mitochondrial oxidative function depend on pyridoxal 5'-phosphate homeostasis protein., [RefSeq, PubMed]; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6., [UniProtKB, HAMAP, PubMed]; Studies suggest that PROSC is involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate, supplying this cofactor to apoenzymes while minimizing any toxic side reactions, [RefSeq, PubMed]; This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid tumors of epithelial origin. Naturally occurring mutations in this gene are associated with a pyridoxine-dependent epilepsy. [provided by RefSeq, Mar 2017]., [RefSeq]; We therefore confirm PROSC as a novel gene for vitamin-B6-dependent epilepsy and delineate a non-specific plasma vitamin B6 profile under pyridoxine treatment., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FI94",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030170 pyridoxal phosphate binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0042816 vitamin B6 metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "O94903-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NWS1-1",
        "uniprot_id": [
            {
                "id": "PARI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NWS1",
                "type": "external"
            }
        ],
        "mass": 65054.0,
        "length": 579,
        "protein_name": "PCNA-interacting partner",
        "gene_name": "PARPBP",
        "organism": "Human",
        "refseq_name": "PCNA-interacting partner isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001306917",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001306917",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PARPBP; C12orf48; PARI",
        "gene_names_refseq": "AROM; C12orf48; PARI; PARPBP",
        "protein_names_uniprotkb": "PCNA-interacting partner; PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP",
        "protein_names_refseq": "PCNA-interacting partner isoform 1; PCNA-interacting partner",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55010)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "11237011;20931645;22153967;22544926;23436799;23481700;24715725;25418920;25576301;25645385;25880248;26375851;26792895;26992070;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29769354;29786170;29805304;30315122;30379171;30429286;30524438;30833945;30949905;30967629;31154438;31222486;31611199;31844290;32157095;32357974;32387766;32897882;32938616;33141586;33298915;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34509645;34932366;35051231;35154160;35580925;36010968;36056690;36241641;36284347",
        "class_list": "",
        "function": "Demonstrated that C12orf48 protein could directly interact with Poly(ADP-ribose) Polymerase-1 (PARP-1). Knockdown of C12orf48 by siRNA in PDAC cells significantly suppressed their growth., [RefSeq, PubMed]; PARI inhibits homologous recombination in vivo, and its knockdown suppresses the UV sensitivity of RAD18-depleted cells, [RefSeq, PubMed]; PARI overexpression promotes genomic instability and pancreatic tumorigenesis., [RefSeq, PubMed]; PARI plays potential oncogenic roles and functions as a transcriptional target and effector of FOXM1 in gastric cancer development Publication Status: Online-Only, [RefSeq, PubMed]; PARI suppresses inappropriate recombination events at mammalian replication forks., [RefSeq, PubMed]; PARP1-binding protein was significantly upregulated in Hepatocellular Carcinoma tissues compared with normal liver. High PARPBP expression was associated with elevated serum AFP level, vascular invasion, poor tumor differentiation, and advanced TNM stage., [RefSeq, PubMed]; PARPBP expression is enhanced in lung adenocarcinoma tissues and is a potential factor in the progression of lung adenocarcinoma., [RefSeq, PubMed]; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect., [UniProtKB, PubMed, PubMed]; SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP., [RefSeq, PubMed]; Show that PARI expression negatively correlates with expression of differentiation markers in clinical myeloid leukemia samples, suggesting that targeting PARI may restore differentiation ability of leukemia cells and antagonize their proliferation, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E0Y0;Q05C00;Q499L8;Q4FZA0;Q4KMW7;Q6NSC6;Q6PJA1;Q86W36",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005634 nucleus",
        "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q9NWS1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UPP1-1",
        "uniprot_id": [
            {
                "id": "PHF8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UPP1",
                "type": "external"
            }
        ],
        "mass": 117864.0,
        "length": 1060,
        "protein_name": "Histone lysine demethylase PHF8",
        "gene_name": "PHF8",
        "organism": "Human",
        "refseq_name": "histone lysine demethylase PHF8 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001171825",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171825",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF8; KDM7B; KIAA1111; ZNF422",
        "gene_names_refseq": "JHDM1F; KDM7B; MRXSSD; PHF8; ZNF422",
        "protein_names_uniprotkb": "Histone lysine demethylase PHF8; 1.14.11.-; 1.14.11.65; Lysine demethylase 7B; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8",
        "protein_names_refseq": "[histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8; histone lysine demethylase PHF8 isoform 1; histone lysine demethylase PHF8; jumonji C domain-containing histone demethylase 1F; lysine demethylase 7B; zinc finger protein 422",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Siderius type (Disease Ontology:DOID:0060812); prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:23133);  (R-HSA-3214842)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15620353;16199551;16362057;16603237;16603238;16732292;16732293;16738407;17081983;17310255;17320163;17351631;17661819;17713478;17947579;18498374;18669648;19502796;19690332;19727073;19843542;20023638;20067792;20068231;20084082;20101266;20129925;20208542;20346720;20421419;20457893;20531378;20548336;20622853;20622854;21406692;21532585;22544926;22615488;22645359;23092983;23186163;24714562;24715725;25576301;26154972;26728094;26992070;27846572;27920218;28063628;28510447;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29563586;29632046;29632711;29786170;30315122;30379171;30429286;30779550;30833945;31154438;31691806;31844290;31848261;31998317;32051553;32157095;32357974;32387766;32502341;32938616;32983136;33010150;33141586;33298915;33592498;33633747;33912179;33936100;33968037;34171305;34211107;34509645;34561969;35051231;35254053;35318648;35580925;36010968;37938771;38253038;39323294;39454680;40596516",
        "class_list": "",
        "function": "A novel missense mutation c.836C>T of the PHF8 gene was identified in a Finnish family with multiple-affected male patients with X-linked mental retardation, [RefSeq, PubMed]; An important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate, [RefSeq, PubMed]; Deletion of the PHF8 gene is associated with the X-linked mental retardation Siderius-Hamel syndrome and the larger size of the Xp11.22 deletion including genes FAM120C and WNK3 may be involved in the pathogenesis of autism. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Histone demethylase PHF8 protected against chondrocyte injury and alleviated posttraumatic osteoarthritis by epigenetically enhancing WWP2 expression., [RefSeq, PubMed]; Histone lysine demethylase with selectivity for mono- and dimethylated residues. It plays an essential role in cell cycle progression and rDNA transcription (PubMed:19843542, PubMed:20531378, PubMed:20548336, PubMed:20622854). Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks (PubMed:20101266, PubMed:20208542, PubMed:20346720, PubMed:20622853, PubMed:20622854). Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2) (PubMed:20346720). May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo (PubMed:19843542, PubMed:20023638, PubMed:20346720). Involved in cell cycle progression by being required to control G1-S transition (PubMed:20622854). Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes (PubMed:20531378). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3 (PubMed:20023638, PubMed:20346720, PubMed:20421419). Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for brain development, probably by regulating expression of neuron-specific genes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice., [RefSeq, PubMed]; Molecular mechanism underlying PHF8-associated developmental and neurological diseases., [RefSeq, PubMed]; PHF8 exerts a positive effect on rDNA transcription, with transcriptional activation requiring both the JmjC domain and the PHD finger. PHF8 demethylates H3K9me1/2, and its catalytic activity is stimulated by adjacent H3K4me3, [RefSeq, PubMed]; PHF8 is an Fe(II) and 2-oxoglutarate-dependent N(epsilon)-methyl lysine demethylase. GeneRIF: PHF8 is a histone lysine demethylase with di-/monomethyl state selectivity. Clinical PHF8 mutants disrupt PHF8 activity. Oxygen-dependence of PHF8 activity suggests link with increased incidence of cleft lip/palate from maternal hypoxia during gestation., [RefSeq, PubMed]; Results rationalize the lack of activity for the clinically observed F279S PHF8 variant and they will help to identify inhibitors selective for specific N(epsilon)-methyl lysine demethylase subfamilies., [RefSeq, PubMed]; The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMV4;B7Z911;Q5H9U5;Q5JPR9;Q5JPS0;Q5JPS2;Q5JPS3;Q5VUJ4;Q7Z6D4;Q9HAH2",
        "ec_number_list": [
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "1.14.11.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66",
                "type": "external"
            },
            {
                "id": "1.14.11.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65",
                "type": "external"
            },
            {
                "id": "1.14.99.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0048188 Set1C/COMPASS complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "Q9UPP1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00469-1",
        "uniprot_id": [
            {
                "id": "PLOD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00469",
                "type": "external"
            }
        ],
        "mass": 84686.0,
        "length": 737,
        "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2",
        "gene_name": "PLOD2",
        "organism": "Human",
        "refseq_name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_000926",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000926",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLOD2",
        "gene_names_refseq": "BRKS2; LH2; PLOD2; TLH",
        "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; 1.14.11.4; LH2; Lysyl hydroxylase 2",
        "protein_names_refseq": "lysine hydroxylase 2; lysyl hydroxlase 2; lysyl hydroxylase 2; procollagen lysyl hydroxylase 2; procollagen-lysine 5-dioxygenase; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor; telopeptide lysyl hydroxylase; telopeptidyl lysyl hydroxylase",
        "tax_id": 9606,
        "disease": "Bruck syndrome (Disease Ontology:DOID:0060231); hypothyroidism (Disease Ontology:DOID:1459); lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:5352);  (R-HSA-1650814)",
        "pathway_count": 2,
        "publication_count": 124,
        "publication_id_list": "37268159;10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;10372558;10479448;10934207;11237011;12473679;12475640;12646579;12881513;1323838;14500733;15044469;15523624;1577494;16591531;18088087;18487197;18512783;19075007;19159218;19693541;20068231;20470363;21209280;21878990;21967573;22689593;23090970;23301498;23345538;24190977;25418920;2543975;25502872;25645385;25892735;26154972;26811146;26853435;26992070;27397612;27846572;27920218;28218747;28228285;28467828;28514659;28855257;28904123;29177700;29178448;29393594;29437277;29508533;29557506;29632046;29741879;29769354;29786170;29983323;30315122;30410026;30429286;30484775;30833945;31472299;3173483;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32938616;33141586;33214551;33298915;33465208;33592498;33717175;33912179;33968037;34019948;34087483;34089345;34171305;34185709;34211107;34357683;34433824;34561969;34725712;34846842;35008409;35051231;35154160;35580925;35601416;36010968;36284347;36581221;37074911;37481725;38008826;38233403;38665916;38696846;3905801;3938630;39531497;39769143;40596516;41018975;6307276;6809411;710450;9054364;9545296;9560306;9582318",
        "class_list": "glycogene",
        "function": "Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4., [RefSeq, PubMed]; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation. Publication Status: Online-Only, [RefSeq, PubMed]; METTL3 facilitates renal cell carcinoma progression by PLOD2 m[6]A-methylation under prolonged hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis., [RefSeq, PubMed]; The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 993,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 45,
        "disease_count": 3,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWS3;Q59ED2;Q8N170",
        "ec_number_list": [
            {
                "id": "1.14.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4",
                "type": "external"
            },
            {
                "id": "2.4.1.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50",
                "type": "external"
            },
            {
                "id": "2.4.1.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.9,
        "record_id": "O00469-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00168-1",
        "uniprot_id": [
            {
                "id": "PLM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00168",
                "type": "external"
            }
        ],
        "mass": 10441.0,
        "length": 92,
        "protein_name": "Phospholemman",
        "gene_name": "FXYD1",
        "organism": "Human",
        "refseq_name": "phospholemman precursor",
        "refseq_ac": [
            {
                "id": "NP_001265646",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265646",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FXYD1; PLM",
        "gene_names_refseq": "FXYD1; PLM",
        "protein_names_uniprotkb": "Phospholemman; FXYD domain-containing ion transport regulator 1; Sodium/potassium-transporting ATPase subunit FXYD1",
        "protein_names_refseq": "phospholemman precursor; phospholemman; sodium/potassium-transporting ATPase subunit FXYD1",
        "tax_id": 9606,
        "disease": "congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:5348);  (R-HSA-5578775);  (R-HSA-936837);  (R-HSA-9679191)",
        "pathway_count": 4,
        "publication_count": 105,
        "publication_id_list": "10087012;10220561;10401004;10484781;10615129;10767338;10811636;10913253;10950925;11062458;11237011;11904675;12119109;12832055;12953268;15174025;15260953;15598648;15754088;15831496;15919184;15925480;16115318;16182249;16522641;1656976;16597826;16700898;16754674;1693919;17224452;17357072;17486119;17511473;17662961;18723824;18995841;19278978;19345671;19751721;19878721;20166139;20223979;20388710;21108950;21220422;2160952;21868384;22186024;22210847;2226863;22401777;22427649;22552008;22707725;22814904;22972900;23196729;23362265;23549614;23610579;23641311;24272870;2430951;24392018;24584101;2477373;2559024;25801024;25994790;26002965;26429909;26791827;26992070;27067231;2838329;28425720;28645727;29383885;2953725;29557506;29945920;30201761;31048504;31154438;31848261;32063830;33231612;34270462;6328127;6832622;7626145;7702581;7929371;7999001;8045293;8298639;8490646;8490659;8798450;8918259;9147644;9169143;9307043;9346285",
        "class_list": "",
        "function": "A period of high-intensity training with reduced training volume increases expression and phosphorylation levels of FXYD1, which may affect Na(+)/K(+) pump activity and muscle K(+) homeostasis during intense exercise., [RefSeq, PubMed]; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Blood flow restriction augmented exercise-induced increases in muscle FXYD1 and PGC-1alpha mRNA in men, [RefSeq, PubMed]; Expression mode and prognostic value of FXYD family members in colon cancer., [RefSeq, PubMed]; FXYD protein isoforms differentially modulate human Na/K pump function., [RefSeq, PubMed]; Stopped-flow experiments using the dye RH421 show that FXYD1 slows the conformational transition E2(2K)ATP --> E1(3Na)ATP but does not affect 3NaE1P --> E2P3Na., [RefSeq, PubMed]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K196",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005254 chloride channel activity;GO:0099106 ion channel regulator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0008016 regulation of heart contraction;GO:0006883 intracellular sodium ion homeostasis;GO:0006821 chloride transport;GO:0010248 establishment or maintenance of transmembrane electrochemical gradient",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "O00168-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60733-1",
        "uniprot_id": [
            {
                "id": "PLPL9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60733",
                "type": "external"
            }
        ],
        "mass": 89903.0,
        "length": 806,
        "protein_name": "85/88 kDa calcium-independent phospholipase A2",
        "gene_name": "PLA2G6",
        "organism": "Human",
        "refseq_name": "85/88 kDa calcium-independent phospholipase A2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001004426",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLA2G6; PLPLA9",
        "gene_names_refseq": "CaI-PLA2; GVI; INAD1; IPLA2-VIA; NBIA2A; NBIA2B; NBIA2; PARK14; PLA2G6; PLA2; PNPLA9; iPLA2beta; iPLA2",
        "protein_names_uniprotkb": "85/88 kDa calcium-independent phospholipase A2; 2-lysophosphatidylcholine acylhydrolase; 3.1.1.4; 3.1.1.5; 3.1.2.2; CaI-PLA2; GVI PLA2; Group VI phospholipase A2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; PNPLA9; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; iPLA2-beta",
        "protein_names_refseq": "2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2 isoform b; 85/88 kDa calcium-independent phospholipase A2; GVI PLA2; iPLA2-beta; intracellular membrane-associated calcium-independent phospholipase A2 beta; neurodegeneration with brain iron accumulation 2; palmitoyl-CoA hydrolase; patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent)",
        "tax_id": 9606,
        "disease": "Parkinson's disease 14 (Disease Ontology:DOID:0060900); dystonia 12 (Disease Ontology:DOID:0090056); neurodegeneration with brain iron accumulation 2a (Disease Ontology:DOID:0110735); neurodegeneration with brain iron accumulation 2b (Disease Ontology:DOID:0110736); pleurisy (Disease Ontology:DOID:10247); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); neuroaxonal dystrophy (Disease Ontology:DOID:2367)",
        "pathway": " (hsa:8398);  (R-HSA-1482788);  (R-HSA-1482798);  (R-HSA-1482839);  (R-HSA-2029485);  (R-HSA-6811436)",
        "pathway_count": 6,
        "publication_count": 137,
        "publication_id_list": "10085124;10092647;10224668;10336645;10358058;10359595;10455175;10559986;10562278;10579907;10681567;11031251;11080672;11112443;11237011;11425868;11483508;11749377;11830583;12150957;12161451;12359733;12401177;12432908;12447383;12522102;12660731;12869549;12925777;14551214;14709560;15152008;15161916;15294978;15483056;15536084;15695510;15809313;15863501;15914536;15944408;1618844;16207721;16243729;16314391;16497229;16617059;16678913;16704971;16783378;16818490;16864775;17033970;17082194;17182612;17488286;17590538;17827179;18195019;18208975;18287005;18458083;18477386;18570303;18614531;18641641;18664496;18772128;18781350;19019078;19029121;1904318;19075029;19164547;19351971;19416660;19501189;19635840;19737925;19753100;20420828;20705608;20886109;21173190;21515882;22130221;22562055;22605381;22825852;23333653;23481700;23533611;23749988;23783758;24891604;25233431;25453831;26463208;26503625;27846572;27920218;28832583;28887846;28904123;29242379;2925608;2925633;31844290;32157095;32161166;32357974;32387766;32502341;33592498;33912179;34357683;34509645;35051231;35580925;38764027;39425167;39796207;7060561;7517665;8083230;8228618;8300559;8657103;9030515;9050864;9188469;9417066;9487141;9671731;9705332;9733780;9973503",
        "class_list": "",
        "function": "An estimation of global genetic prevalence of PLA2G6-associated neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10092647, PubMed:10336645, PubMed:20886109, PubMed:9417066). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position (PubMed:10092647, PubMed:10336645, PubMed:20886109). Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:20886109). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:23533611). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species (By similarity). Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (By similarity). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:20886109). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (PubMed:18208975). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G protein receptors in various cell types (By similarity). Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms., [UniProtKB, PubMed]; Mapped a locus for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA) to chromosome 22q12-q13 and identified mutations in PLA2G6, encoding a group VI phospholipase A2, in NBIA, INAD and Karak syndrome Erratum:[Nat Genet. 2006 Aug;38(8):957], [RefSeq, PubMed]; Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K597;B0QYE8;O75645;Q8N452;Q9UG29;Q9UIT0;Q9Y671",
        "ec_number_list": [
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "2.3.1.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.5.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.4.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1",
                "type": "external"
            },
            {
                "id": "2.3.1.149",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0017171 serine hydrolase activity;GO:0004622 phosphatidylcholine lysophospholipase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031143 pseudopodium",
        "go_biological_process": "GO:0046338 phosphatidylethanolamine catabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006935 chemotaxis;GO:0019731 antibacterial humoral response",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "O60733-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21549-1",
        "uniprot_id": [
            {
                "id": "AGT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21549",
                "type": "external"
            }
        ],
        "mass": 43010.0,
        "length": 392,
        "protein_name": "Alanine--glyoxylate aminotransferase",
        "gene_name": "AGXT",
        "organism": "Human",
        "refseq_name": "alanine--glyoxylate aminotransferase",
        "refseq_ac": [
            {
                "id": "NP_000021",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000021",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "AGXT; AGT1; SPAT",
        "gene_names_refseq": "AGT1; AGT; AGXT1; AGXT; PH1; SPAT; SPT; Ser-PyrAT; TLH6",
        "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase; 2.6.1.44; 2.6.1.51; AGT; SPT; Serine--pyruvate aminotransferase",
        "protein_names_refseq": "L-alanine: glyoxylate aminotransferase 1; alanine--glyoxylate aminotransferase; alanine--glyoxylate and serine--pyruvate aminotransferase; hepatic peroxisomal alanine:glyoxylate aminotransferase; serine--pyruvate aminotransferase",
        "tax_id": 9606,
        "disease": "primary hyperoxaluria type 1 (Disease Ontology:DOID:0111670); primary hyperoxaluria (Disease Ontology:DOID:2977)",
        "pathway": " (hsa:189);  (R-HSA-389661);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 129,
        "publication_id_list": "10022913;10347152;10394939;10453743;10484776;10524214;10541294;10562279;10673331;10777549;10862087;10960483;10978532;11101887;11546814;11781871;11931631;12456682;12559034;12559847;12578380;12717447;12777626;12865426;12885776;12899834;1301173;1349575;13681368;13681370;14170323;15253729;15340920;15545321;15802217;15849466;15858711;15961946;15963748;1601857;16616139;16854980;16971151;17007944;1703535;17088322;17495019;17669354;17726030;18215067;18359941;18712838;19197237;19208625;19352492;19584060;19632994;20018850;20178365;2039493;2045108;20603179;21554508;2158891;21976670;21980954;21998747;22002062;22057399;22371489;22516612;2253628;22747494;23229545;2363689;23963456;24055001;24235149;24275569;24865970;24934730;25016021;25538232;25697095;25747990;25854684;26086376;26138649;26149463;26220973;26344566;26858947;26992070;27597759;28521612;28611990;28765278;28787099;29557506;31154438;32488085;32938616;3416563;35051231;35580925;35661454;37874369;38243391;38657121;500817;6250440;7719337;7790377;8101040;8507692;8824437;8858165;8991089;9090381;9090382;9090383;9163533;9192270;9539740;9604803;9653144;9668159;9820813;9837948",
        "class_list": "",
        "function": "Case series and literature review of primary hyperoxaluria type 1 in Chinese patients. Publication Status: Online-Only, [RefSeq, PubMed]; Expanding the Genetic Spectrum of AGXT Gene Variants in Egyptian Patients with Primary Hyperoxaluria Type I., [RefSeq, PubMed]; Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants., [RefSeq, PubMed]; Next-generation sequencing in identification of pathogenic variants in primary hyperoxaluria among 21 Egyptian families: Identification of two novel AGXT gene mutations., [RefSeq, PubMed]; Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:23229545, PubMed:24055001, PubMed:26149463). Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism (PubMed:10347152)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53QU6",
        "ec_number_list": [
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42",
                "type": "external"
            },
            {
                "id": "1.3.3.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "3.4.24.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56",
                "type": "external"
            },
            {
                "id": "1.4.3.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3",
                "type": "external"
            },
            {
                "id": "2.6.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51",
                "type": "external"
            },
            {
                "id": "2.6.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44",
                "type": "external"
            },
            {
                "id": "2.3.1.176",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "4.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4",
                "type": "external"
            },
            {
                "id": "2.3.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137",
                "type": "external"
            },
            {
                "id": "2.3.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.5.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.4.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.184",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
                "type": "external"
            },
            {
                "id": "1.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38",
                "type": "external"
            },
            {
                "id": "2.6.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.40",
                "type": "external"
            },
            {
                "id": "2.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.18",
                "type": "external"
            },
            {
                "id": "1.3.1.124",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124",
                "type": "external"
            },
            {
                "id": "1.1.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15",
                "type": "external"
            },
            {
                "id": "1.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1",
                "type": "external"
            },
            {
                "id": "1.5.3.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7",
                "type": "external"
            },
            {
                "id": "5.1.99.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4",
                "type": "external"
            },
            {
                "id": "4.1.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63",
                "type": "external"
            },
            {
                "id": "1.2.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004760 L-serine-pyruvate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0046487 glyoxylate metabolic process;GO:0042853 L-alanine catabolic process;GO:0009436 glyoxylate catabolic process;GO:0019265 glycine biosynthetic process, by transamination of glyoxylate;GO:0006563 L-serine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "P21549-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P09327-1",
        "uniprot_id": [
            {
                "id": "VILI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P09327",
                "type": "external"
            }
        ],
        "mass": 92695.0,
        "length": 827,
        "protein_name": "Villin-1",
        "gene_name": "VIL1",
        "organism": "Human",
        "refseq_name": "villin-1",
        "refseq_ac": [
            {
                "id": "NP_009058",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009058",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VIL1; VIL",
        "gene_names_refseq": "D2S1471; VIL1; VIL",
        "protein_names_uniprotkb": "Villin-1",
        "protein_names_refseq": "villin-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7429)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "11237011;11500485;12269817;14550699;14594952;15084600;15096633;15272027;15342783;16921170;17182858;17229814;17606613;18054784;18198174;18482983;19491107;19808673;24275569;26992070;27397612;27862975;28411811;2846586;28953659;29274870;29557506;29741879;29789417;30192525;30379171;30397120;3087992;31154438;31844290;31848261;32387766;32520642;33024199;34185709;3453110;35051231;35580925;37217939",
        "class_list": "",
        "function": "Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; F-actin-bundling sites are conserved in proteins with villin-type headpiece domains., [RefSeq, PubMed]; Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin., [RefSeq, PubMed]; This gene encodes a member of a family of calcium-regulated actin-binding proteins.  This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments.  Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Villin has a higher positive expression in Primary Pulmonary Enteric Adenocarcinoma cases. Villin proved to be a very sensitive and helpful enteric marker in the differential diagnosis between PEAC and other lung adenocarcinomas., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 26,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9A7;Q53S11;Q96AC8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061041 regulation of wound healing;GO:0051125 regulation of actin nucleation;GO:0001951 intestinal D-glucose absorption",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "P09327-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53H76-1",
        "uniprot_id": [
            {
                "id": "PLA1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53H76",
                "type": "external"
            }
        ],
        "mass": 49715.0,
        "length": 456,
        "protein_name": "Phospholipase A1 member A",
        "gene_name": "PLA1A",
        "organism": "Human",
        "refseq_name": "phospholipase A1 member A isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001193889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLA1A; NMD; PSPLA1",
        "gene_names_refseq": "PLA1A; PS-PLA1; PSPLA1",
        "protein_names_uniprotkb": "Phospholipase A1 member A; 3.1.1.111; PS-PLA1; Phosphatidylserine-specific phospholipase A1",
        "protein_names_refseq": "phosphatidylserine-specific phospholipase A1alpha; phospholipase A1 member A isoform 2 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51365);  (R-HSA-1482801)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10196188;10455175;10681567;11031251;11112443;11237011;11830583;12161451;12359733;12436198;12522102;17101204;18287005;18458083;18614531;18772128;19554302;20705608;21220512;22906437;23481700;23934110;24715725;25502872;25645385;25892735;26206935;27600516;28228285;28467828;28832583;29242379;2925608;29786170;30626607;31978406;32060356;32350084;33723350;34078123;34433824;34884486;35358472;37217939;7060561;8300559;9074642;9188469",
        "class_list": "",
        "function": "Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism., [RefSeq, PubMed]; Hydrolyzes lyso-PS but not PS., [UniProtKB, PubMed]; Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase A-Dependent Pathway., [RefSeq, PubMed]; Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8V2;B4DXA2;O95991;Q86WX6;Q9UPD2",
        "ec_number_list": [
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.111",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.1.118",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008970 phospholipase A1 activity;GO:0120560 phosphatidylserine lysophospholipase activity;GO:0016298 lipase activity;GO:0046872 metal ion binding;GO:0052689 carboxylic ester hydrolase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0002080 acrosomal membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process;GO:0036150 phosphatidylserine acyl-chain remodeling;GO:0006658 phosphatidylserine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q53H76-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TBJ4-1",
        "uniprot_id": [
            {
                "id": "PLPR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TBJ4",
                "type": "external"
            }
        ],
        "mass": 35795.0,
        "length": 325,
        "protein_name": "Phospholipid phosphatase-related protein type 1",
        "gene_name": "PLPPR1",
        "organism": "Human",
        "refseq_name": "phospholipid phosphatase-related protein type 1",
        "refseq_ac": [
            {
                "id": "NP_060223",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060223",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLPPR1; LPPR1; PRG3",
        "gene_names_refseq": "LPPR1; PLPPR1; PRG-3",
        "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 1; Inactive 2-lysophosphatidate phosphatase PLPPR1; Lipid phosphate phosphatase-related protein type 1; PRG-3; Plasticity-related gene 3 protein",
        "protein_names_refseq": "inactive 2-lysophosphatidate phosphatase PLPPR1; lipid phosphate phosphatase-related protein type 1; phospholipid phosphatase-related protein type 1; plasticity related gene 3; plasticity-related gene 3 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54886);  (R-HSA-419408)",
        "pathway_count": 2,
        "publication_count": 23,
        "publication_id_list": "10488065;10488122;10617617;10727522;10753843;10799507;11237011;12427546;12730698;14750979;19366702;20061941;2160972;23388400;24900670;26990079;29735753;31844290;8626678;8878560;9070858;9525886;9804623",
        "class_list": "",
        "function": "May play a role in neurite outgrowth and neurogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VX23;Q9NXE2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8TBJ4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IWS0-1",
        "uniprot_id": [
            {
                "id": "PHF6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IWS0",
                "type": "external"
            }
        ],
        "mass": 41290.0,
        "length": 365,
        "protein_name": "PHD finger protein 6",
        "gene_name": "PHF6",
        "organism": "Human",
        "refseq_name": "PHD finger protein 6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001015877",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015877",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF6; CENP-31; KIAA1823",
        "gene_names_refseq": "BFLS; BORJ; CENP-31; PHF6",
        "protein_names_uniprotkb": "PHD finger protein 6; PHD-like zinc finger protein",
        "protein_names_refseq": "PHD finger protein 6 isoform 1; PHD-like zinc finger protein; centromere protein 31",
        "tax_id": 9606,
        "disease": "Borjeson-Forssman-Lehmann syndrome (Disease Ontology:DOID:0050681); colorectal carcinoma (Disease Ontology:DOID:0080199); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:84295);  (R-HSA-9940951)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "10204490;10970879;10978333;11237011;12415272;14714741;14714754;14756673;17081983;17287340;17525332;17646674;18077418;18452278;18669648;18691976;19413330;19562805;19651622;19664995;19690332;20068231;20230923;20813266;21406692;23186163;23229552;23906836;24554700;25150861;25218447;25593309;26154972;27633282;27732854;27846572;27920218;28218747;28510447;28904123;29042441;29242379;29437277;29493099;30045876;30134174;30524438;31492838;31530632;31746185;31844290;32119511;32399860;32502341;33298915;33968037;34019948;36008597;36756714;36967443;37217939;38418452;38812997;39181868;40596516;7969165;9512513",
        "class_list": "",
        "function": "'...mutations within a novel widely expressed zinc-finger gene (PHF6) have been described in nine families with Borjesson-Forssman-Lehmann syndrome...' p. 1208, [RefSeq, PubMed]; 'The gene, PHF6, implicated in the Borjeson-Forssman-Lehmann syndrome has recently been identified.' p. 1295, [RefSeq, PubMed]; A novel, widely expressed zinc-finger (plant homeodomain[PHD]-like finger) gene had 8 different missense and truncation mutations in 7 familial and 2 sporadic cases of BFLS (p. 661)., [RefSeq, PubMed]; A study of 9 families with PHF6 muations revealed that the phenotype is milder and more variable than previously described and evolves with age; seven missense mutations and two truncation mutations were identifed, [RefSeq, PubMed]; Investigating the physiological role of S199A and S199D mutants of PHF6 protein in T-cell acute lymphoblastic leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting. Publication Status: Online-Only, [RefSeq, PubMed]; PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression. Publication Status: Online-Only, [RefSeq, PubMed]; PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T-cell infiltration., [RefSeq, PubMed]; PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by cognitive disability, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010]., [RefSeq]; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K230;B4E0G4;D3DTG3;E9PC97;Q5JRC7;Q5JRC8;Q96JK3;Q9BRU0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0043021 ribonucleoprotein complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q8IWS0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NV79-1",
        "uniprot_id": [
            {
                "id": "PCMD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NV79",
                "type": "external"
            }
        ],
        "mass": 41072.0,
        "length": 361,
        "protein_name": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 2",
        "gene_name": "PCMTD2",
        "organism": "Human",
        "refseq_name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001098395",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098395",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PCMTD2; C20orf36",
        "gene_names_refseq": "C20orf36; PCMTD2",
        "protein_names_uniprotkb": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 2",
        "protein_names_refseq": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform 2; protein-L-isoaspartate O-methyltransferase domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55251)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;23481700;25880248;26992070;27397612;28832583;28904123;29493099;29557506;29632711;29786170;30429286;31154438;31844290;32157095;32357974;32387766;32938616;33298915;33912179;33968037;34185709;35051231;35580925;37938771",
        "class_list": "",
        "function": "May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5H3;Q8IW60;Q9H4K2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9NV79-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96C36-1",
        "uniprot_id": [
            {
                "id": "P5CR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96C36",
                "type": "external"
            }
        ],
        "mass": 33637.0,
        "length": 320,
        "protein_name": "Pyrroline-5-carboxylate reductase 2",
        "gene_name": "PYCR2",
        "organism": "Human",
        "refseq_name": "pyrroline-5-carboxylate reductase 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001258610",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258610",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PYCR2",
        "gene_names_refseq": "HLD10; P5CR2; PYCR2",
        "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase 2; 1.5.1.2; P5C reductase 2; P5CR 2",
        "protein_names_refseq": "P5C reductase 2; pyrroline-5-carboxylate reductase 2 isoform 2; pyrroline-5-carboxylate reductase family member 2",
        "tax_id": 9606,
        "disease": "hypomyelinating leukodystrophy 10 (Disease Ontology:DOID:0060788); autosomal recessive cutis laxa type IIB (Disease Ontology:DOID:0070137)",
        "pathway": " (hsa:29920);  (R-HSA-8964539)",
        "pathway_count": 2,
        "publication_count": 79,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11903050;12054821;14654843;15364907;16267323;16730026;16964243;1737786;18005987;18669648;19338303;19413330;19648921;20068231;20657015;21406692;23024808;23186163;24366607;24715725;24930674;25576301;25865492;26634742;26733354;26902786;26992070;2722838;27920218;28467828;28510447;28832583;28834231;28904123;29242379;29508533;29557506;29605689;30524438;31217245;31422819;31844290;32157095;32350084;32357974;32387766;32502341;32938616;33141586;33298915;33465208;33912179;33936100;33968037;34185709;34229054;34357683;34509645;34932366;35051231;35138101;35251023;36010968;36240223;37141741;37217939;37329534;37508547;37708598;4052435;40596516;429360;6819292;6894153;7883047;8294935;9514741",
        "class_list": "",
        "function": "Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development., [RefSeq, PubMed]; It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1., [RefSeq, PubMed]; LncRNA MALAT1 regulates growth of carcinoma of the lung through modulating miR-338-3p/PYCR2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway., [RefSeq, PubMed]; Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/beta-Catenin Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Pyrroline-5-carboxylate reductase 2 (PYCR2) deficiency causes hereditary spastic paraplaegia in late childhood., [RefSeq, PubMed]; Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K798;Q7Z515;Q9Y5J4",
        "ec_number_list": [
            {
                "id": "1.5.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0055129 L-proline biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q96C36-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16816-1",
        "uniprot_id": [
            {
                "id": "PHKG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16816",
                "type": "external"
            }
        ],
        "mass": 45024.0,
        "length": 387,
        "protein_name": "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform",
        "gene_name": "PHKG1",
        "organism": "Human",
        "refseq_name": "phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001245388",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245388",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHKG1; PHKG",
        "gene_names_refseq": "PHKG1; PHKG",
        "protein_names_uniprotkb": "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; 2.7.11.19; 2.7.11.1; 2.7.11.26; PHK-gamma-M; Phosphorylase kinase subunit gamma-1; Serine/threonine-protein kinase PHKG1",
        "protein_names_refseq": "PHK-gamma-M; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform 1; phosphorylase kinase gamma subunit 1; phosphorylase kinase subunit gamma-1; phosphorylase kinase, gamma 1 (muscle); serine/threonine-protein kinase PHKG1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5260);  (R-HSA-70221)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "10487978;10949035;11237011;12604216;12825073;12930917;13115432;15118078;17344846;18323634;21767668;24715725;2667896;28904123;29557506;2961257;3049072;33392160;35150045;4829444;5264799;5461220;7847371;7902568;7935360;8420990;8530014;8755644;8896567;9504428;9691087",
        "class_list": "",
        "function": "Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity)., [UniProtKB]; Lung adenocarcinoma-derived vWF promotes tumor metastasis by regulating PHKG1-mediated glycogen metabolism., [RefSeq, PubMed]; This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z1D0;F5H2S1;Q75LP5",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
            },
            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004689 phosphorylase kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0050321 tau-protein kinase activity",
        "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007165 signal transduction;GO:0005975 carbohydrate metabolic process;GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q16816-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P63135-1",
        "uniprot_id": [
            {
                "id": "POK7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P63135",
                "type": "external"
            }
        ],
        "mass": 165184.0,
        "length": 1459,
        "protein_name": "Endogenous retrovirus group K member 7 Pol protein",
        "gene_name": "ERVK-7",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "ERVK-7",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 7 Pol protein; HERV-K(III) Pol protein; HERV-K102 Pol protein; HERV-K_1q22 provirus ancestral Pol protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "10469592;11401426;12060620;12629516;33141586;38253038",
        "class_list": "",
        "function": "Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution., [UniProtKB]; May possess a function in tumorigenesis., [UniProtKB]; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution., [UniProtKB]; Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases., [UniProtKB]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]; The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "2.7.7.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "3.1.26.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4",
                "type": "external"
            },
            {
                "id": "3.4.23.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.50",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.7.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005634 nucleus",
        "go_biological_process": "GO:0006310 DNA recombination;GO:0006261 DNA-templated DNA replication;GO:0015074 DNA integration;GO:0016032 viral process;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P63135-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.010000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WUB8-1",
        "uniprot_id": [
            {
                "id": "PHF10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WUB8",
                "type": "external"
            }
        ],
        "mass": 56051.0,
        "length": 498,
        "protein_name": "PHD finger protein 10",
        "gene_name": "PHF10",
        "organism": "Human",
        "refseq_name": "PHD finger protein 10 isoform a",
        "refseq_ac": [
            {
                "id": "NP_060758",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060758",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF10; BAF45A",
        "gene_names_refseq": "BAF45A; PHF10; SMARCG4; XAP135",
        "protein_names_uniprotkb": "PHD finger protein 10; BAF45a; BRG1-associated factor 45a; XAP135",
        "protein_names_refseq": "BRG1-associated factor 45a; BRG1-associated factor, 45-KD, A; PHD finger protein 10 isoform a; PHD zinc finger protein XAP135",
        "tax_id": 9606,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)",
        "pathway": " (hsa:55274);  (R-HSA-9933939);  (R-HSA-9933946);  (R-HSA-9934037)",
        "pathway_count": 4,
        "publication_count": 96,
        "publication_id_list": "10078207;11827455;12368262;15302935;15640446;15985610;16265664;17081983;17498659;17640523;18212344;18220336;18452278;18669648;18809673;19413330;19651622;19690332;20068231;20068294;21406692;22464331;23186163;23481700;23644491;23785148;24275569;24397554;24715725;25218447;25418920;25576301;25892735;26154972;26365797;26601204;26811146;26929215;26992070;27600516;27862975;27920218;28717195;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632046;29769354;29786170;29789417;30315122;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31911482;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32983136;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34465901;34509645;34561969;34932366;35033590;35051231;35318648;35580925;36241641;36284347;37938771;38189889;8804307",
        "class_list": "",
        "function": "Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)., [UniProtKB]; Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression., [RefSeq, PubMed]; PHF10 subunit of PBAF complex mediates transcriptional activation by MYC., [RefSeq, PubMed]; This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]., [RefSeq]; ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2YDA3;Q53HG8;Q9BXD2;Q9NV26",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071564 npBAF complex;GO:0016363 nuclear matrix;GO:0000776 kinetochore",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "Q8WUB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H3S1-1",
        "uniprot_id": [
            {
                "id": "SEM4A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H3S1",
                "type": "external"
            }
        ],
        "mass": 83574.0,
        "length": 761,
        "protein_name": "Semaphorin-4A",
        "gene_name": "SEMA4A",
        "organism": "Human",
        "refseq_name": "semaphorin-4A isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001180229",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180229",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEMA4A; PRO1317; SEMAB; SEMB",
        "gene_names_refseq": "CORD10; RP35; SEMA4A; SEMAB; SEMB",
        "protein_names_uniprotkb": "Semaphorin-4A; Sema B; Semaphorin-B",
        "protein_names_refseq": "sema B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; semaphorin-4A isoform 1 precursor; semaphorin-B",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 35 (Disease Ontology:DOID:0110357); cone-rod dystrophy 10 (Disease Ontology:DOID:0111017)",
        "pathway": " (hsa:64218);  (R-HSA-416700)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "10.1101/2023.09.13.557529;10520995;10648410;11114375;11237011;12882840;12975309;15218527;15550623;16199541;16715077;17318185;18452278;18991276;22299025;22956603;24190977;24715725;25502872;25576301;25892735;26992070;27058226;27846572;27920218;28218747;28228285;28467828;28805479;28832583;29242379;29437277;29508533;29632711;29769354;30315122;30410026;30626607;31530632;31844290;32350084;32387766;32897882;32983136;33043033;33633747;33717175;33912179;34357683;34433824;34509645;34932366;35051231;35154160;35460904;35580925;36581221;37074911;37205755;37901456;39062540;8955171",
        "class_list": "",
        "function": "Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)., [UniProtKB, UniProtKB]; Semaphorin 4A Maintains Trophoblastic Function via Activating the STAT3 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Semaphorin4A promotes lung cancer by activation of NF-kappaB pathway mediated by PlexinB1. Publication Status: Online-Only, [RefSeq, PubMed]; The possible involvement of sema3A and sema4A in the pathogenesis of multiple sclerosis., [RefSeq, PubMed]; This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]., [RefSeq]; Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8[+] T cell cytotoxicity and proliferation., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDH8;B3KR76;Q5TCI5;Q5TCJ6;Q8WUA9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0001525 angiogenesis;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9H3S1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UPW6-1",
        "uniprot_id": [
            {
                "id": "SATB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UPW6",
                "type": "external"
            }
        ],
        "mass": 82555.0,
        "length": 733,
        "protein_name": "DNA-binding protein SATB2",
        "gene_name": "SATB2",
        "organism": "Human",
        "refseq_name": "DNA-binding protein SATB2",
        "refseq_ac": [
            {
                "id": "NP_001165980",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165980",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SATB2; KIAA1034",
        "gene_names_refseq": "C2DELq32q33; DEL2Q32Q33; GLSS; SATB2",
        "protein_names_uniprotkb": "DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2",
        "protein_names_refseq": "DNA-binding protein SATB2; SATB family member 2; SATB2 fusion; special AT-rich sequence-binding protein 2",
        "tax_id": 9606,
        "disease": "SATB2-associated syndrome (Disease Ontology:DOID:0060428); isolated cleft palate (Disease Ontology:DOID:0110213)",
        "pathway": " (hsa:23314);  (R-HSA-4551638);  (R-HSA-8940973)",
        "pathway_count": 3,
        "publication_count": 98,
        "publication_id_list": "10.1101/2023.09.13.557529;11106645;11237011;11545733;11960997;12032081;12231506;12391164;12529404;12915443;14578449;14701874;14765127;15199155;15592428;16025100;16099986;16327884;16751105;16953426;17018294;17287340;17377962;18408014;18477452;18628979;18691969;19170718;19389811;19651622;19801668;20098713;20112406;20351170;20417598;20686481;20877012;21136679;21173110;22402492;22493095;23186163;23750026;24068740;24369422;24782567;25218447;25391492;25576301;25645385;25704882;25755297;25772364;25865393;25892735;26967290;26992070;27068747;27397612;27797343;28832583;29393594;29557506;29789417;30379171;30779550;31154438;31844290;31848261;32157095;32387766;32488085;32897882;32938616;32938750;33141586;33392160;33537174;33592498;33968037;33981976;34171305;34185709;34405274;34509645;35051231;35561310;36010968;36241641;37877736;37938771;37984605;38244545;38555678;39327041;39531497;7891679;9182762",
        "class_list": "",
        "function": "Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation., [UniProtKB, PubMed]; Circular RNA CircSATB2 facilitates osteosarcoma progression through regulating the miR-661/FUS-mediated mRNA of ZNFX1., [RefSeq, PubMed]; Concomitant expression patterns of CDX2 and SATB2 as prognostic factors in stage III colorectal cancers., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Pathogenic SATB2 missense variants affecting p.Gly392 have variable functional implications and result in diverse clinical phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; SATB2 is identified as the cleft palate gene on chromosome pair 2 which undergoes translocation., [RefSeq, PubMed]; SATB2 organizes the 3D genome architecture of cognition in cortical neurons., [RefSeq, PubMed]; Single-cell sequencing reveals SATB2/NOTCH1 signaling promotes the progression of malignancy of epithelial cells from papillary thyroid cancer., [RefSeq, PubMed]; This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5Z8;Q3ZB87;Q4V763",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0000118 histone deacetylase complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q9UPW6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z699-1",
        "uniprot_id": [
            {
                "id": "SPRE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z699",
                "type": "external"
            }
        ],
        "mass": 50477.0,
        "length": 444,
        "protein_name": "Sprouty-related, EVH1 domain-containing protein 1",
        "gene_name": "SPRED1",
        "organism": "Human",
        "refseq_name": "sprouty-related, EVH1 domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_689807",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689807",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPRED1",
        "gene_names_refseq": "LGSS; NFLS; PPP1R147; SPRED1; hSpred1; spred-1",
        "protein_names_uniprotkb": "Sprouty-related, EVH1 domain-containing protein 1; Spred-1; hSpred1",
        "protein_names_refseq": "protein phosphatase 1, regulatory subunit 147; sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation",
        "tax_id": 9606,
        "disease": "Legius syndrome (Disease Ontology:DOID:0070484)",
        "pathway": " (hsa:161742);  (R-HSA-5658442);  (R-HSA-5658623);  (R-HSA-6802953)",
        "pathway_count": 4,
        "publication_count": 73,
        "publication_id_list": "11237011;11418238;11493923;12600938;12646235;12787671;15580519;1568246;15683364;1570011;1570015;16115197;16478641;17094949;17704776;18061161;18216281;18578522;18772396;18772890;18948947;19443465;19467855;19573811;19715689;19920134;20108422;20230923;20655465;21089071;2121370;21616146;22108604;22432025;22751498;22802525;23112089;23171796;23186163;23443682;23640895;23661552;24026051;24129315;24576830;24705354;24814062;25645385;26214590;28228285;29557506;30379171;31848261;32157095;32350084;32697994;32983136;33073945;33078527;33306107;33592498;34185709;34357683;35580925;36284347;36629984;37217939;37434064;8490657;8563751;9219684;9302992;9668168",
        "class_list": "",
        "function": "A Study on the Expression of SPRED1 and PBRM1 (Baf180) and their Clinical Significances in Patients with Gastric Cancer., [RefSeq, PubMed]; Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis., [RefSeq, PubMed]; Moyamoya syndrome in a child with Legius syndrome: Introducing a cerebral vasculopathy to the SPRED1 phenotype?, [RefSeq, PubMed]; SPOCK2 and SPRED1 function downstream of EZH2 to impede the malignant progression of lung adenocarcinoma in vitro and in vivo., [RefSeq, PubMed]; SPRED1 deletion confers resistance to MAPK inhibition in melanoma., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]., [RefSeq]; Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPJ8;Q05D53;Q8N256",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0019901 protein kinase binding;GO:0019902 phosphatase binding;GO:0030291 protein serine/threonine kinase inhibitor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005901 caveola",
        "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0016525 negative regulation of angiogenesis;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator",
        "synthesized_glycan_count": 0,
        "hit_score": 7.7,
        "record_id": "Q7Z699-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99611-1",
        "uniprot_id": [
            {
                "id": "SPS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99611",
                "type": "external"
            }
        ],
        "mass": 47305.0,
        "length": 448,
        "protein_name": "Selenide, water dikinase 2",
        "gene_name": "SEPHS2",
        "organism": "Human",
        "refseq_name": "selenide, water dikinase 2",
        "refseq_ac": [
            {
                "id": "NP_036380",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036380",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEPHS2; SPS2",
        "gene_names_refseq": "SEPHS2; SPS2",
        "protein_names_uniprotkb": "Selenide, water dikinase 2; 2.7.9.3; Selenium donor protein 2; Selenophosphate synthase 2",
        "protein_names_refseq": "selenide, water dikinase 2; selenium donor protein 2; selenophosphate synthase 2; selenoprotein SEPHS2",
        "tax_id": 9606,
        "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)",
        "pathway": " (hsa:22928);  (R-HSA-2408557)",
        "pathway_count": 2,
        "publication_count": 49,
        "publication_id_list": "10970870;11265756;15317934;15534230;15821744;16508009;17142313;19608919;23934683;24275569;24715725;25418920;25576301;26138980;26992070;27397612;28414460;28514659;28904123;29242379;29393594;29557506;29632046;29786170;30315122;30410026;30524438;31695102;31844290;32157095;32387766;32488085;32938616;33123756;33298915;33592498;33936100;33981976;34087483;34171305;34509645;35051231;35580925;37938771;7588067;8890909;8986768;9431993;9637248",
        "class_list": "",
        "function": "Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS, SECP43, SEPHS1, and SEPHS2); SECP43, which interacts with SEPSECS and SEPHS1, is a globular protein that forms oligomers in vivo., [RefSeq, PubMed]; MiR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression.In the case of SEPHS2 this may contribute to maintaining selenoprotein synthesis., [RefSeq, PubMed]; Selenophosphate synthase that generates the selenium donor for selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP., [UniProtKB, PubMed]; Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The Sps1-encoded enzyme depends on a selenium salvage system that recycles l-selenocysteine, whereas the Sps2 enzyme can function with a selenite assimilation system, [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BUQ2",
        "ec_number_list": [
            {
                "id": "2.7.9.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0016260 selenocysteine biosynthetic process;GO:0016259 selenocysteine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q99611-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15060-1",
        "uniprot_id": [
            {
                "id": "ZBT39_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15060",
                "type": "external"
            }
        ],
        "mass": 79001.0,
        "length": 712,
        "protein_name": "Zinc finger and BTB domain-containing protein 39",
        "gene_name": "ZBTB39",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 39",
        "refseq_ac": [
            {
                "id": "NP_055645",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055645",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZBTB39; KIAA0352",
        "gene_names_refseq": "ZBTB39; ZNF922",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 39",
        "protein_names_refseq": "zinc finger and BTB domain-containing protein 39",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9880)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "25576301;25645385;26992070;28904123;29393594;30524438;32357974;32387766;32938616;33298915;33392160;33912179;33968037;34405274;34509645;35051231;35561310;36010968;8358434",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MD38;Q9UD98",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "O15060-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EK2-1",
        "uniprot_id": [
            {
                "id": "PF21B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EK2",
                "type": "external"
            }
        ],
        "mass": 57455.0,
        "length": 531,
        "protein_name": "PHD finger protein 21B",
        "gene_name": "PHF21B",
        "organism": "Human",
        "refseq_name": "PHD finger protein 21B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001129334",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129334",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF21B; KIAA1661",
        "gene_names_refseq": "BHC80L; PHF21B; PHF4",
        "protein_names_uniprotkb": "PHD finger protein 21B",
        "protein_names_refseq": "PHD finger protein 21B isoform 2; PHD finger protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:112885)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;18477386;24714562;25454821;27777418;28645312;29485866;29557506;31154438;31844290;35051231;37938771",
        "class_list": "",
        "function": "PHF21B constitutively activated wnt/beta-catenin signaling by transcriptionally downregulating SFRP1 and SFRP2, which promotes prostate cancer stem cell-like phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; PHF21b variants contribute significantly to differences in the levels of expression of this gene in several brain areas, including the hippocampus. Furthermore, using an animal model of stress, we found that Phf21b hippocampal gene expression is significantly decreased in animals resilient to chronic restraint stress when compared with non-chronically stressed animals., [RefSeq, PubMed]; These data suggest that PHF21B is a novel tumor suppressor gene that can be inactivated by genetic and epigenetic mechanisms in the human cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QYW3;B0QYW4;B3KRU4;B7Z4F8;Q5TFL2;Q6ICC0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96EK2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BZM1-1",
        "uniprot_id": [
            {
                "id": "PG12A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BZM1",
                "type": "external"
            }
        ],
        "mass": 21067.0,
        "length": 189,
        "protein_name": "Group XIIA secretory phospholipase A2",
        "gene_name": "PLA2G12A",
        "organism": "Human",
        "refseq_name": "group XIIA secretory phospholipase A2 precursor",
        "refseq_ac": [
            {
                "id": "NP_110448",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110448",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLA2G12A; FKSG38; PLA2G12; PRO6012",
        "gene_names_refseq": "GXII; PLA2G12A; PLA2G12; ROSSY",
        "protein_names_uniprotkb": "Group XIIA secretory phospholipase A2; 3.1.1.4; GXII sPLA2; Phosphatidylcholine 2-acylhydrolase 12A; sPLA2-XII",
        "protein_names_refseq": "GXII sPLA2; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; group XIIA secretory phospholipase A2 precursor; group XIIA secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; phospholipase A2, group XII; sPLA2-XII",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81579);  (R-HSA-1482788);  (R-HSA-1482801);  (R-HSA-1482839);  (R-HSA-1482922);  (R-HSA-1482925);  (R-HSA-1483166)",
        "pathway_count": 7,
        "publication_count": 141,
        "publication_id_list": "10085124;10092647;10196188;10336645;10358058;10455175;10506173;10553003;10681567;11031251;11112443;11237011;11788596;11830583;12063250;12150957;12161451;12359733;12522102;12963729;12975309;14573790;14709560;15367102;15485873;15695510;15863501;15944408;1618844;16243729;16460752;16495223;16617059;16620771;16704971;16818490;16864775;17028579;17101204;17170135;17182612;17707131;18094042;18195019;18238778;18287005;18458083;18614531;18718904;18772128;18781350;19019078;1904318;19336658;19351971;19501189;19554302;19666841;20025994;20628086;20705608;21173190;21220512;21515882;22424782;22605381;22777291;22825852;22906437;22922100;23176821;23176823;23481700;23807634;23934110;24966474;25576301;25645385;26154972;26206935;26463208;26503625;26711011;26811146;27434078;27920218;28228285;28832583;28904123;29242379;2925608;2925633;29493099;29527719;29557506;29632711;30315122;30779550;31154438;31611695;31844290;31937595;32157095;32350084;32357974;32387766;32502341;32938616;33141586;33298915;33537174;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;3458202;35051231;35251023;35580925;36010968;36241641;37938771;38703030;7060561;7821823;8083230;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9417066;9461603;9582313;9705332",
        "class_list": "",
        "function": "Cellular arachidonate (AA) release and prostaglandin (PG) production are regulated by novel classes of secretory phospholipase A(2)s (sPLA(2)s), groups III and XII, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine., [UniProtKB, PubMed, UniProtKB, UniProtKB]; PLA2G12A protects against diet-induced obesity and insulin resistance by enhancing energy expenditure and clearance of circulating triglycerides., [RefSeq, PubMed]; Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]., [RefSeq]; The results of this study revealed that PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia., [RefSeq, PubMed]; The study demonstrated that PLA2G12A SNPs or haplotypes might influence the susceptibility to schizophrenia in the Han Chinese population from Northeast China. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BZ89",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0006644 phospholipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.2,
        "record_id": "Q9BZM1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92968-1",
        "uniprot_id": [
            {
                "id": "PEX13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92968",
                "type": "external"
            }
        ],
        "mass": 44130.0,
        "length": 403,
        "protein_name": "Peroxisomal membrane protein PEX13",
        "gene_name": "PEX13",
        "organism": "Human",
        "refseq_name": "peroxisome biogenesis factor 13",
        "refseq_ac": [
            {
                "id": "NP_002609",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002609",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX13",
        "gene_names_refseq": "NALD; PBD11A; PBD11B; PEX13; ZWS",
        "protein_names_uniprotkb": "Peroxisomal membrane protein PEX13; Peroxin-13",
        "protein_names_refseq": "peroxin-13; peroxisomal membrane protein PEX13; peroxisome biogenesis factor 13",
        "tax_id": 9606,
        "disease": "peroxisome biogenesis disorder 11A (Disease Ontology:DOID:0080485); Peroxisome biogenesis disorder 11B (Disease Ontology:DOID:0081439); peroxisomal disease (Disease Ontology:DOID:906)",
        "pathway": " (hsa:5194);  (R-HSA-8866654);  (R-HSA-9033241);  (R-HSA-9603798)",
        "pathway_count": 4,
        "publication_count": 176,
        "publication_id_list": "10022913;10332040;10430017;10441330;10441568;10562279;10673331;10704444;11101887;11237011;11390669;11402059;11453642;11546814;11590176;11740563;11781871;11883941;11931631;12456682;12559034;12578380;12717447;12751901;12885776;12924628;14709540;15007061;15215855;15215856;15545321;15713480;15781447;15858711;16280322;16307923;16791427;16854980;16868077;16895967;16980692;17007944;17041890;17069900;17108083;17130289;17726030;18174172;18316726;18359941;18712838;18719106;18782765;19197237;19208625;19410543;19449432;19584060;19632994;19723507;20178365;20531392;20554521;21102411;21203937;21329877;21396873;21554508;21976670;21980954;22002062;22021426;22057399;22371489;22624858;22747494;23460677;23628762;23963456;24235149;24662292;24807418;24865970;24979766;25016021;25030448;25062251;25170678;25517356;25538232;25576301;25854684;25892735;25936802;26086376;26138649;26210183;26216882;26220973;26344566;26350214;26711259;26777132;26811146;27569044;27597759;27798111;27846572;27862975;27920218;28228285;28281558;28325759;28521612;28611990;28765278;28787099;28832583;28834231;28855257;28904123;29242379;29314611;29393594;29557506;29632046;29769354;29786170;29789417;30315122;30410026;30524438;30779550;30833945;31092671;31154438;31611695;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32897882;32938616;32983136;33298915;33912179;33936100;33968037;33981976;34171305;34211107;35051231;35318648;35561310;35580925;35854306;36010968;38632234;40739340;7719337;7790377;8625414;8824437;8858165;8991089;9090381;9090382;9090383;9418908;9539740;9653144;9668159;9837948",
        "class_list": "",
        "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:28765278, PubMed:8858165, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:28765278, PubMed:8858165, PubMed:9653144). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:8858165, PubMed:9653144)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders. Publication Status: Online-Only, [RefSeq, PubMed]; Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm. Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders, an example of which is Zellweger syndrome. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCS1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008320 protein transmembrane transporter activity",
        "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0001967 suckling behavior;GO:0007626 locomotory behavior;GO:0001764 neuron migration;GO:0021795 cerebral cortex cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 17.7,
        "record_id": "Q92968-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12931-1",
        "uniprot_id": [
            {
                "id": "TRAP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12931",
                "type": "external"
            }
        ],
        "mass": 80110.0,
        "length": 704,
        "protein_name": "Heat shock protein 75 kDa, mitochondrial",
        "gene_name": "TRAP1",
        "organism": "Human",
        "refseq_name": "heat shock protein 75 kDa, mitochondrial isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001258978",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258978",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TRAP1; HSP75; HSPC5",
        "gene_names_refseq": "HSP 75; HSP75; HSP90L; TRAP-1; TRAP1",
        "protein_names_uniprotkb": "Heat shock protein 75 kDa, mitochondrial; HSP 75; Heat shock protein family C member 5; TNFR-associated protein 1; TRAP-1; Tumor necrosis factor type 1 receptor-associated protein",
        "protein_names_refseq": "TNFR-associated protein 1; heat shock protein 75 kDa, mitochondrial isoform 2; heat shock protein 75 kDa, mitochondrial; heat shock protein family C member 5; testicular tissue protein Li 209; tumor necrosis factor type 1 receptor-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10131);  (R-HSA-611105);  (R-HSA-71403)",
        "pathway_count": 3,
        "publication_count": 150,
        "publication_id_list": "10.1101/2023.09.13.557529;10327278;1052766;10545594;10652318;10673423;10727444;11237011;11278619;11695836;12207025;12231006;12837546;13181903;1327877;14249115;14555658;14741580;14832224;14946179;15234968;15250827;15652751;15877282;15987702;16143825;16230336;16737955;16740313;17033964;17182618;17432878;17668387;17924679;18663603;186667;18669648;18806796;18914071;1946331;19608861;19651622;2005110;20068231;20435888;20847235;22645359;23150584;23186163;23270816;23301498;23481700;23525905;23564345;23747254;239860;24275569;25564869;25880248;25892735;26024233;26154972;26375851;26853435;26992070;27189937;27374498;27846572;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28887308;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29769354;30315122;30397120;30524438;30761759;30779550;30833945;30844107;31154438;31217245;31530632;31844290;32119511;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33058874;33141586;33214551;33298915;33392160;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34509645;34561969;34725712;34932366;35051231;35366151;35580925;36010968;36139014;36241641;36420423;37165028;37487647;38665916;39088352;39210159;39302247;40914422;4288886;7876093;8200987;8616157;8756626;9765290;9765291;9792106;9792662;9809442;9878551",
        "class_list": "",
        "function": "Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA., [UniProtKB, PubMed, PubMed, PubMed]; Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins., [RefSeq, PubMed]; TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation., [RefSeq, PubMed]; TRAP1 modulates mitochondrial biogenesis via PGC-1alpha/TFAM signalling pathway in colorectal cancer cells., [RefSeq, PubMed]; This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DR68;D3DUC8;F5H897;O43642;O75235;Q9UHL5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0016020 membrane",
        "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0006457 protein folding;GO:0009386 translational attenuation;GO:1901856 negative regulation of cellular respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "Q12931-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96SU4-1",
        "uniprot_id": [
            {
                "id": "OSBL9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96SU4",
                "type": "external"
            }
        ],
        "mass": 83185.0,
        "length": 736,
        "protein_name": "Oxysterol-binding protein-related protein 9",
        "gene_name": "OSBPL9",
        "organism": "Human",
        "refseq_name": "oxysterol-binding protein-related protein 9 isoform g",
        "refseq_ac": [
            {
                "id": "NP_001317509",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317509",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OSBPL9; ORP9; OSBP4",
        "gene_names_refseq": "ORP-9; ORP9; OSBPL9",
        "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 9; ORP-9; OSBP-related protein 9",
        "protein_names_refseq": "OSBP-related protein 9; oxysterol-binding protein-related protein 9 isoform g; oxysterol-binding protein-related protein 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114883);  (R-HSA-192105)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "11237011;11735225;11802775;16962287;17081983;17428193;18991276;19413330;20599956;22223895;22424782;22906437;23033978;23186163;23428468;23481700;23830809;24209621;24275569;24714562;24715725;24742681;25418920;25576301;25645385;25880248;26154972;26375851;26715851;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29485866;29493099;29508533;29557506;29605689;29632711;29786170;30315122;30410026;30429286;30524438;30779550;30833945;31020640;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33968037;33981976;34087483;34171305;34357683;34405274;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36853333;39106189;9852097",
        "class_list": "",
        "function": "Furthermore, mammalian target of rapamycin was implicated in ORP9L phosphorylation in HEK293 cells. These studies identify ORP9 as a PDK-2 substrate and negative regulator of Akt phosphorylation at the PDK-2 site., [RefSeq, PubMed]; Includes data showing N-alpha terminal acetylation of this protein (OSBL9_HUMAN), which begins with nASIMEGPLSK following cleavage of the initiating Met-1 residue., [RefSeq, PubMed]; Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). Interacts with OSBPL10 to function as lipid transfer proteins (PubMed:36853333). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:36853333)., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AKJ8;B3KPQ4;D3DQ31;Q5TFC0;Q6IA67;Q86YQ3;Q8NB17;Q8TAS8;Q96SK4;Q9H9X2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0032934 sterol binding;GO:0120015 sterol transfer activity;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane",
        "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0006649 phospholipid transfer to membrane;GO:0055091 phospholipid homeostasis;GO:0097212 lysosomal membrane organization;GO:0120009 intermembrane lipid transfer",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "Q96SU4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZWE6-1",
        "uniprot_id": [
            {
                "id": "PKHM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZWE6",
                "type": "external"
            }
        ],
        "mass": 87166.0,
        "length": 761,
        "protein_name": "Pleckstrin homology domain-containing family M member 3",
        "gene_name": "PLEKHM3",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family M member 3",
        "refseq_ac": [
            {
                "id": "NP_001073944",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073944",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHM3; DAPR; PLEKHM1L",
        "gene_names_refseq": "DAPR; PLEKHM1L; PLEKHM3",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 3; Differentiation associated protein; PH domain-containing family M member 3",
        "protein_names_refseq": "PH domain-containing family M member 3; differentiation associated protein; pleckstrin homology domain-containing family M member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389072)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;19028694;19651622;19664994;25576301;26992070;28832583;29393594;30429286;31623606;31844290;32157095;32387766;32502341;32938616;32983136;33141586;33298915;33912179;33968037;34171305;34509645;35051231;35580925",
        "class_list": "",
        "function": "CircPLEKHM3 is down-regulated in ovarian cancer. Patients with a lower circPLEKHM3 expression have a worse prognosis. CircPLEKHM3 was found to act as a tumor suppressor that inhibits cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; DAPR is a novel gene that binds to PKB/AKT and is a critical component for the differentiation of skeletal muscle myoblast cells into myotubes., [RefSeq, PubMed]; Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EKV2;Q8WW68",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0045445 myoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q6ZWE6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H4B0-1",
        "uniprot_id": [
            {
                "id": "OSGL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H4B0",
                "type": "external"
            }
        ],
        "mass": 45123.0,
        "length": 414,
        "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial",
        "gene_name": "OSGEPL1",
        "organism": "Human",
        "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1",
        "refseq_ac": [
            {
                "id": "NP_071748",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071748",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OSGEPL1; GCP1",
        "gene_names_refseq": "OSGEPL1; OSGEPL; Qri7",
        "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase-like protein 1; OSGEP-like protein 1; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1",
        "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase-like protein 1; OSGEP-like protein 1; probable O-sialoglycoprotein endopeptidase 2; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1; putative sialoglycoprotease type 2; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64172);  (R-HSA-6787450)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "11237011;12456664;15509579;16826519;19694617;19732863;20877624;21890497;22608499;23042678;23097428;23625533;23814040;23929671;24126054;24901367;25552653;25925575;26992070;28218747;28510447;28832583;28904123;29242379;29390138;29437277;29557506;29760464;30315122;30410026;30833945;31217245;31844290;31848261;32047918;32387766;32938616;33912179;34509645;35051231;9512533",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance., [UniProtKB, HAMAP, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96EV9;Q96NH5",
        "ec_number_list": [
            {
                "id": "2.3.1.234",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0070900 mitochondrial tRNA modification;GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q9H4B0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UM63-1",
        "uniprot_id": [
            {
                "id": "PLAL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UM63",
                "type": "external"
            }
        ],
        "mass": 50819.0,
        "length": 463,
        "protein_name": "Zinc finger protein PLAGL1",
        "gene_name": "PLAGL1",
        "organism": "Human",
        "refseq_name": "zinc finger protein PLAGL1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001074420",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074420",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAGL1; LOT1; ZAC",
        "gene_names_refseq": "LOT1; PLAGL1; ZAC1; ZAC",
        "protein_names_uniprotkb": "Zinc finger protein PLAGL1; LOT-1; Lost on transformation 1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC",
        "protein_names_refseq": "PLAG-like 1; lost on transformation 1; pleiomorphic adenoma gene-like 1; tumor suppressor ZAC; zinc finger protein PLAGL1 isoform 2; zinc finger protein PLAGL1",
        "tax_id": 9606,
        "disease": "transient neonatal diabetes mellitus 1 (Disease Ontology:DOID:0061173)",
        "pathway": " (hsa:5325);  (R-HSA-6804115)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10.1101/2023.09.13.557529;10655556;11237011;11313869;11814693;11896574;11935319;12897130;14968113;15713436;16140933;16160013;17146433;17341487;18299245;18337750;18622393;19276069;20352051;20531387;22252318;23236473;23481700;31154438;31717259;31844290;31848261;32157095;32161166;32265295;32357974;32938616;33298915;34171305;34185709;35051231;35494241;35580925;36241641;36284347;38639853;39228008;8944033;9150364;9184226;9671765;9712883;9722527",
        "class_list": "",
        "function": "Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide., [UniProtKB, PubMed, PubMed]; Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide., [UniProtKB, UniProtKB]; Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse., [RefSeq, PubMed]; Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement. Publication Status: Online-Only, [RefSeq, PubMed]; PLAGL1 gene is imprinted, with preferential expression from the paternal allele in many tissues., [RefSeq, PubMed]; This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]., [RefSeq]; Tissue-specific imprinting of PLAGL1 gene results from variable use of monoallelic and biallelic promoters., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBA4;B2RCM8;E1P595;E1P597;O76019;Q7Z3V8;Q92981;Q96JR9;Q9UIZ0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0002682 regulation of immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9UM63-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15147-1",
        "uniprot_id": [
            {
                "id": "PLCB4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15147",
                "type": "external"
            }
        ],
        "mass": 134464.0,
        "length": 1175,
        "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4",
        "gene_name": "PLCB4",
        "organism": "Human",
        "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a",
        "refseq_ac": [
            {
                "id": "NP_000924",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000924",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCB4",
        "gene_names_refseq": "ARCND2A; ARCND2B; ARCND2; PI-PLC; PLCB4",
        "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 3.1.4.11; PLC-beta-4; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4",
        "protein_names_refseq": "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a; PLC-beta-4; dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)); inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C-beta-4; triphosphoinositide phosphodiesterase",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466); auriculocondylar syndrome 2 (MONDO:MONDO:0013845); auriculocondylar syndrome 2B (MONDO:MONDO:0957544)",
        "pathway": " (hsa:5332);  (R-HSA-112043);  (R-HSA-1855204);  (R-HSA-416476)",
        "pathway_count": 4,
        "publication_count": 92,
        "publication_id_list": "10191087;10567430;10593988;10727532;10861009;10866302;11015615;11022047;11022048;11042108;11118617;11237011;11742120;11753430;11909533;12120503;12223481;12747803;1322796;1333955;15037625;15140260;15316017;15474001;15579586;15702972;15790568;15951850;16107206;16182515;16268778;16339447;1644792;16754659;16923326;1718960;18434541;18515384;18577758;18936096;1905813;19179337;21406692;22560091;23315542;23913798;2550068;25645385;27007857;27600516;28328130;2841328;29242379;29331515;29557506;30379171;30429286;3086311;31217245;31844290;32157095;32201334;32387766;32488085;32938616;33592498;34899595;34905385;35051231;35170830;35284927;35580925;36010968;36284347;37938771;38715801;7721860;7761412;7890667;7937899;8407970;8454637;8530101;8662638;8664309;8723348;8769125;9305846;9360711;9430698;9593664;9770463",
        "class_list": "",
        "function": "Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants., [RefSeq, PubMed]; Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and GEMIN2 (rs2277458) variants with bone mineral density and serum 25-hidroxivitamin D levels in Mexican Mestizo women. Publication Status: Online-Only, [RefSeq, PubMed]; The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]., [RefSeq]; Uveal melanoma-associated mutations in PLCbeta4 are constitutively activating and promote melanocyte proliferation and tumorigenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLK6;E2QRH8;Q17R56;Q5JYS8;Q5JYS9;Q5JYT0;Q5JYT3;Q5JYT4;Q9BQW5;Q9BQW6;Q9BQW8;Q9UJQ2",
        "ec_number_list": [
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005790 smooth endoplasmic reticulum",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q15147-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NPF4-1",
        "uniprot_id": [
            {
                "id": "OSGEP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NPF4",
                "type": "external"
            }
        ],
        "mass": 36427.0,
        "length": 335,
        "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase",
        "gene_name": "OSGEP",
        "organism": "Human",
        "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase",
        "refseq_ac": [
            {
                "id": "NP_060277",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060277",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OSGEP; GCPL1",
        "gene_names_refseq": "GAMOS3; GCPL1; KAE1; OSGEP1; OSGEP; PRSMG1; TCS3",
        "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase; hOSGEP; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP",
        "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; hOSGEP; probable O-sialoglycoprotein endopeptidase; probable tRNA N6-adenosine threonylcarbamoyltransferase; probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA N6-adenosine threonylcarbamoyltransferase",
        "tax_id": 9606,
        "disease": "primary hypomagnesemia (Disease Ontology:DOID:0060879); Galloway-Mowat syndrome 3 (Disease Ontology:DOID:0080245); proteinuria (Disease Ontology:DOID:576)",
        "pathway": " (hsa:55644);  (R-HSA-6782315)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10430867;10982862;11027153;11111046;11237011;12039036;12403464;15861136;15870694;15994936;16043508;16424344;17071714;18567810;19017811;19414587;20123966;20308323;20354154;20584901;21059936;21131277;22344696;22544926;22591353;22912744;22995836;23042678;23048041;23381944;23481700;23604283;24126054;24204302;24715725;24901367;25261850;25404562;25576301;25645385;25880248;25916855;26154972;26160102;26310293;26375851;26992070;27055666;27846572;27862975;27903914;28218747;28228285;28272532;28510447;28805828;28832583;29242379;29331515;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30524438;30779550;30833945;31481669;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33633747;33968037;33981976;34171305;34211107;34405274;34509645;34614169;34666032;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;36610787;37938771;38253038;40596516;40914422;9430663;9851972",
        "class_list": "",
        "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]; Novel variants in OSGEP leading to Galloway-Mowat syndrome by altering its subcellular localization., [RefSeq, PubMed]; The structural and functional workings of KEOPS. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAC3",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.234",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex",
        "go_biological_process": "GO:0006400 tRNA modification;GO:1990145 maintenance of translational fidelity;GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q9NPF4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P07202-1",
        "uniprot_id": [
            {
                "id": "PERT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P07202",
                "type": "external"
            }
        ],
        "mass": 102963.0,
        "length": 933,
        "protein_name": "Thyroid peroxidase",
        "gene_name": "TPO",
        "organism": "Human",
        "refseq_name": "thyroid peroxidase isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_000538",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000538",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TPO",
        "gene_names_refseq": "MSA; TDH2A; TPO; TPX",
        "protein_names_uniprotkb": "Thyroid peroxidase; 1.11.1.8; TPO",
        "protein_names_refseq": "thyroid microsomal antigen; thyroid peroxidase isoform a precursor; thyroperoxidase",
        "tax_id": 9606,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 2A (Disease Ontology:DOID:0112186); glomerulonephritis (Disease Ontology:DOID:2921)",
        "pathway": " (hsa:7173);  (R-HSA-209968)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10084596;10468986;11061528;11237011;11415848;11514595;11874711;11916616;12213873;12454013;12490071;12501244;12843174;12864797;12938097;15030525;15311276;15561711;15611283;15761037;15972824;16284446;16651268;16684826;16735377;16910871;1716262;1722671;19144650;22259066;2308857;23481700;2383265;2548579;27305979;29557506;30315122;30379171;31844290;32157095;32198668;32387766;33968037;3453124;3475693;35051231;3654979;37780999;38482822;38542286;67547;7505290;7550241;7745006;8627148;8806637;9024270;9360522;9525906;9924196",
        "class_list": "",
        "function": "Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity., [RefSeq, PubMed]; Homozygous Mutations in Thyroid Peroxidase (TPO) in Hypothyroidism with Intellectual Disability, Developmental Delay, and Hearing and Ocular Anomalies in Two Families: Severe Manifestation of Untreated TPO-deficiency Poses a Diagnostic Dilemma. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of diversity generated by alternative splicing, [RefSeq, PubMed]; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population? Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P09934;P09935;Q8IUL0;Q8NF94;Q8NF95;Q8NF96;Q8NF97;Q8TCI9",
        "ec_number_list": [
            {
                "id": "1.11.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.8",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "1.6.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1",
                "type": "external"
            },
            {
                "id": "1.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0004447 iodide peroxidase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane",
        "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006979 response to oxidative stress;GO:0042446 hormone biosynthetic process;GO:0042744 hydrogen peroxide catabolic process;GO:0006590 thyroid hormone generation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "P07202-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P41247-1",
        "uniprot_id": [
            {
                "id": "PLPL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P41247",
                "type": "external"
            }
        ],
        "mass": 27980.0,
        "length": 253,
        "protein_name": "Patatin-like phospholipase domain-containing protein 4",
        "gene_name": "PNPLA4",
        "organism": "Human",
        "refseq_name": "patatin-like phospholipase domain-containing protein 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001135861",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135861",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPLA4; DXS1283E; GS2",
        "gene_names_refseq": "DXS1283E; GS2; PNPLA4; iPLA2eta",
        "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 4; 3.1.1.3; 3.1.1.4; Calcium-independent phospholipase A2-eta; Protein GS2; iPLA2-eta",
        "protein_names_refseq": "IPLA2 eta; calcium independent phospholipases A2 eta; calcium-independent phospholipase A2-eta; patatin like phospholipase domain containing 4; patatin-like phospholipase domain-containing protein 4 isoform 1; patatin-like phospholipase domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8228);  (R-HSA-163560)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10671541;11237011;12832420;15364929;15456755;15955102;16150821;16741517;17603008;18691976;19181555;19390624;20068231;21504868;26741492;26992070;27317427;28228285;28904123;29557506;30429286;31092671;31844290;32161166;32350084;32357974;32938616;32983136;33592498;33633747;33912179;33968037;34357683;35051231;35251023;36010968;38973237;7806223",
        "class_list": "",
        "function": "Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease., [RefSeq, PubMed]; Has abundant triacylglycerol lipase activity (PubMed:15364929, PubMed:15955102, PubMed:16150821, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:15955102, PubMed:17603008). Additionally possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17603008). Able to catalyze fatty acyl CoA-dependent retinol esterification during epidermal maturation, when pH becomes acidic (PubMed:15955102)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; IPLA2epsilon (adiponutrin), iPLA2zeta (TTS-2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols, [RefSeq, PubMed]; No association between genetic variants in PNPLA4 genes and childhood and adolescent obesity GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The GS2 gene (PNPLA4) encodes a keratinocyte retinyl ester hydrolase. The protein also catalyzes fatty acyl CoA-dependent and -independent retinol esterification, using triolein as substrate and generates diacylglyceride and free fatty acid., [RefSeq, PubMed]; These results strongly suggest that PNPLA9, -6 and -4 play a key role in GPL turnover and homeostasis in human cells. A hypothetical model suggesting how these enzymes could recognize the relative concentration of the different GPLs is proposed, [RefSeq, PubMed]; This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1H3;B4E362;Q8WW83",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "2.3.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20",
                "type": "external"
            },
            {
                "id": "2.3.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "2.3.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75",
                "type": "external"
            },
            {
                "id": "2.3.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22",
                "type": "external"
            },
            {
                "id": "3.1.1.116",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0016411 acylglycerol O-acyltransferase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0051264 mono-olein transacylation activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0055088 lipid homeostasis;GO:0019433 triglyceride catabolic process;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "P41247-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N3E9-1",
        "uniprot_id": [
            {
                "id": "PLCD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N3E9",
                "type": "external"
            }
        ],
        "mass": 89258.0,
        "length": 789,
        "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",
        "gene_name": "PLCD3",
        "organism": "Human",
        "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",
        "refseq_ac": [
            {
                "id": "NP_588614",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCD3; KIAA1964",
        "gene_names_refseq": "PLC-delta-3; PLCD3",
        "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 3.1.4.11; PLC-delta-3; Phosphoinositide phospholipase C-delta-3; Phospholipase C-delta-3",
        "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; PLC delta3; phosphoinositide phospholipase C-delta-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:113026);  (R-HSA-1855204)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "10336610;10593988;10702670;10866302;11022047;11022048;11042108;11118617;11237011;11500033;11706040;11909533;12223481;12747803;1333955;15037625;15140260;15316017;15474001;15505048;15579586;15702972;15790568;16107206;1644792;17041247;1718960;18452278;18669648;19179337;20068231;20166139;23186163;2550068;25576301;2841328;28832583;29242379;29393594;29632046;31243155;31808619;31844290;32157095;32938616;33592498;33674820;33912179;33968037;33981976;34171305;35051231;36071682;36241641;37166441;37773107;7721860;7761412;7890667;8407970;8454637;8530101;8662638;8723348;8769125;9056492;9360711;9430698;9593664;9799116",
        "class_list": "",
        "function": "CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract., [RefSeq, PubMed]; Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression., [RefSeq, PubMed]; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity)., [UniProtKB, PubMed, UniProtKB]; Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms., [RefSeq, PubMed]; PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway., [RefSeq, PubMed]; This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TEC1;Q8TF37;Q96FL6",
        "ec_number_list": [
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032154 cleavage furrow",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q8N3E9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BRP4-1",
        "uniprot_id": [
            {
                "id": "PAAF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BRP4",
                "type": "external"
            }
        ],
        "mass": 42190.0,
        "length": 392,
        "protein_name": "Proteasomal ATPase-associated factor 1",
        "gene_name": "PAAF1",
        "organism": "Human",
        "refseq_name": "proteasomal ATPase-associated factor 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001254732",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254732",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAAF1; WDR71",
        "gene_names_refseq": "PAAF1; PAAF; Rpn14; WDR71",
        "protein_names_uniprotkb": "Proteasomal ATPase-associated factor 1; Protein G-16; WD repeat-containing protein 71",
        "protein_names_refseq": "WD repeat domain 71; WD repeat-containing protein 71; proteasomal ATPase-associated factor 1 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80227);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10973495;11237011;15831487;16251969;16990800;17189198;17289585;17323924;17540904;17948026;19490896;20471946;22316138;23481700;24715725;25418920;25576301;25645385;26154972;26992070;27846572;27920218;28218747;28263418;28442575;28514659;28598414;28832583;28834231;28904123;29242379;29314611;29437277;29508533;29557506;30315122;30524438;31154438;31530632;31844290;31998317;32157095;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33633747;33968037;34087483;34171305;34446601;34509645;34932366;35051231;35580925;36241641;36284347",
        "class_list": "",
        "function": "Identification of a quality-control factor that monitors failures during proteasome assembly., [RefSeq, PubMed]; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation., [UniProtKB, PubMed, PubMed, PubMed]; Proteasomal ATPase-associated factor 1 (PAAF1) functions as a negative regulator of the proteasome by controlling the assembly/disassembly of the proteasome., [RefSeq, PubMed]; This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDR5;B4DPB0;B7ZAS9;Q4G165;Q53HS9;Q7Z500;Q8TBU6;Q9HAB6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0000502 proteasome complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q9BRP4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13371-1",
        "uniprot_id": [
            {
                "id": "PHLP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13371",
                "type": "external"
            }
        ],
        "mass": 34282.0,
        "length": 301,
        "protein_name": "Phosducin-like protein",
        "gene_name": "PDCL",
        "organism": "Human",
        "refseq_name": "phosducin-like protein",
        "refseq_ac": [
            {
                "id": "NP_005379",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005379",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDCL; PHLOP1; PhLP1",
        "gene_names_refseq": "PDCL; PhLP",
        "protein_names_uniprotkb": "Phosducin-like protein; PHLP",
        "protein_names_refseq": "phosducin-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5082);  (R-HSA-6814122)",
        "pathway_count": 2,
        "publication_count": 83,
        "publication_id_list": "10095058;11230166;11237011;15585822;15889144;16702223;16717095;17081983;17322306;17697703;18669648;18767875;19376773;19413330;19651622;20068231;20112406;23186163;23301498;23637185;23888055;24366607;25418920;25576301;25659125;25675501;26154972;26811146;26929215;26992070;27600516;27846572;27920218;28218747;28228285;28467828;28649982;28832583;28904123;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30410026;30429286;30779550;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;35051231;35154160;35561310;35580925;36241641;36581221;37938771;39894887;9153422",
        "class_list": "",
        "function": "Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin., [UniProtKB]; Acts as a positive regulator of hedgehog signaling and regulates ciliary function., [UniProtKB, UniProtKB]; Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers., [UniProtKB]; Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VXB6;Q96AF1;Q9UEW7;Q9UFL0;Q9UNX1;Q9UNX2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007165 signal transduction;GO:0007601 visual perception;GO:0030030 cell projection organization;GO:1902605 heterotrimeric G-protein complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q13371-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1L390-1",
        "uniprot_id": [
            {
                "id": "PKHG3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A1L390",
                "type": "external"
            }
        ],
        "mass": 134412.0,
        "length": 1219,
        "protein_name": "Pleckstrin homology domain-containing family G member 3",
        "gene_name": "PLEKHG3",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family G member 3",
        "refseq_ac": [
            {
                "id": "NP_001295076",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295076",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHG3; KIAA0599",
        "gene_names_refseq": "ARHGEF43; KIAA0599; PLEKHG3",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 3; PH domain-containing family G member 3",
        "protein_names_refseq": "PH domain-containing family G member 3; pleckstrin homology domain containing, family G (with RhoGef domain) member 3; pleckstrin homology domain containing, family G, member 3; pleckstrin homology domain-containing family G member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26030);  (R-HSA-8980692);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013406);  (R-HSA-9013408)",
        "pathway_count": 6,
        "publication_count": 362,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10619026;10652265;10699171;10699464;10724160;10873388;10873802;10958683;10967094;11007481;11058585;11085924;11149925;11185749;11207612;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11864571;11884391;11912491;11948177;11961559;11967128;12071859;12093360;12096337;12172552;12177196;12195014;12221077;12221096;12242347;12351724;12376551;12432077;12456725;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15546864;15579468;15601624;15611138;15728722;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16339170;16467373;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16968698;17027967;17064668;17077126;17145773;17196961;17214551;17244649;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18218625;18249095;18347018;18363964;18396277;18426980;18653540;18669648;18786931;18829452;18835169;18838382;18929667;19258391;19269969;19494238;19581409;19605563;19635168;19673492;19713215;19934221;20030946;20068231;20101212;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21148482;21351730;21360829;21406692;21454492;21542010;21565175;21613211;21621533;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22461490;22475431;22571869;22608513;22673745;22734669;22911862;22970203;22992742;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24129315;24259668;24275569;24297911;24335996;24352656;24355937;24584464;24659802;24715725;24859002;24933155;24960694;24996924;25024229;25211221;25428919;25576301;25645385;25678704;25704760;25721503;25795300;25862245;25963737;26129894;26299518;26371245;26529257;26598554;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27600516;27713499;27798618;27806292;27862975;27986909;28028151;28112683;28114311;28196833;28467828;28584191;28825699;28832583;28834231;28860633;29089502;29146911;29242379;29358323;29382922;29557506;30061681;30484775;30833945;30853411;31105010;31154438;31844290;31871319;32157095;32203420;32502341;32897882;32938616;32983136;33968037;34087483;34171305;35051231;35580925;36010968;36215666;36241641;39894887;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9792683;9822598;9822605;9829970;9843499;9846874;9857026;9988689",
        "class_list": "",
        "function": "PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front., [RefSeq, PubMed]; Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization., [UniProtKB, PubMed]; This is the first implication of chr14q23.2-23.3 in the etiology of autism and points to MTHFD1, PLEKHG3, and CHURC1 as potential candidate genes contributing to autism risk., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L389;B5MEC9;O60339;Q6GMS3;Q6P4B1;Q7L3S3;Q86SW7;Q8TEF5;Q96EW6;Q9BT82",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030334 regulation of cell migration;GO:2000114 regulation of establishment of cell polarity",
        "synthesized_glycan_count": 0,
        "hit_score": 36.5,
        "record_id": "A1L390-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22079-1",
        "uniprot_id": [
            {
                "id": "PERL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22079",
                "type": "external"
            }
        ],
        "mass": 80288.0,
        "length": 712,
        "protein_name": "Lactoperoxidase",
        "gene_name": "LPO",
        "organism": "Human",
        "refseq_name": "lactoperoxidase isoform 3 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001153574",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153574",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LPO; SAPX",
        "gene_names_refseq": "LPO; SPO",
        "protein_names_uniprotkb": "Lactoperoxidase; 1.11.1.7; LPO; SPO; Salivary peroxidase",
        "protein_names_refseq": "lactoperoxidase isoform 3 preproprotein; salivary peroxidase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4025);  (R-HSA-8941413)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10.1101/2023.09.13.557529;10519157;10715594;10766826;10777476;11237011;12626341;16740002;17074761;18780401;19059195;19402211;206633;21297906;2222811;22348603;23066164;24049667;24715725;24928513;24974109;25309750;25645385;25802875;27048452;28653416;29557506;3032796;30379171;31844290;32125861;32387766;33592498;34509645;35580925;37217939;6295491;8964511",
        "class_list": "",
        "function": "Establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites, [RefSeq, PubMed]; Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (PubMed:6295491). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:12626341). Shows antibacterial properties against Pseudomonas aeruginosa (PubMed:12626341). The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro (PubMed:12626341). Present in mammary and salivary gland secretions and may contribute to airway host defense against infection (PubMed:12626341). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. Publication Status: Online-Only, [RefSeq, PubMed]; LPO mRNA was undetectable in the gastric mucosa., [RefSeq, PubMed]; The crystal structure of the complex of LPO with MZY showed that MZY bound to LPO in the substrate-binding site on the distal heme side. MZY was oriented in the substrate-binding site in such a way that the sulfur atom is at a distance of 2.58 A from the heme iron, [RefSeq, PubMed]; This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5JUY4;E7EMJ3;Q13408;Q3KNQ2",
        "ec_number_list": [
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0036393 thiocyanate peroxidase activity;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042742 defense response to bacterium;GO:0042744 hydrogen peroxide catabolic process;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "P22079-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H7P9-1",
        "uniprot_id": [
            {
                "id": "PKHG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H7P9",
                "type": "external"
            }
        ],
        "mass": 147969.0,
        "length": 1386,
        "protein_name": "Pleckstrin homology domain-containing family G member 2",
        "gene_name": "PLEKHG2",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family G member 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_073746",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073746",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHG2",
        "gene_names_refseq": "ARHGEF42; CLG; CTB-60E11.4; LDAMD; PLEKHG2",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 2; PH domain-containing family G member 2",
        "protein_names_refseq": "PH domain-containing family G member 2; common-site lymphoma/leukemia guanine nucleotide exchange factor; pleckstrin homology domain containing, family G (with RhoGef domain) member 2; pleckstrin homology domain-containing family G member 2 isoform 1; pleckstrin homology domain-containing family G member 2",
        "tax_id": 9606,
        "disease": "leukodystrophy and acquired microcephaly with or without dystonia; (MONDO:MONDO:0014766)",
        "pathway": " (hsa:64857);  (R-HSA-193648);  (R-HSA-416482);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 5,
        "publication_count": 347,
        "publication_id_list": "10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;10958683;11007481;11058585;11085924;11149925;11237011;11283606;11294240;11306516;11313914;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11707441;11742120;11756498;11756552;11773441;11803464;11804587;11804589;11804590;11839748;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12097334;12101119;12123608;12172552;12195014;12221096;12351724;12432077;12433842;12464619;12515866;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14673001;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15470142;15485661;15507211;15579468;15601624;15611138;15699075;15728722;15749160;15850391;15858067;15897194;15951850;16002401;16112081;16116428;16184169;16212495;16217026;16243036;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16777452;16777849;16862148;16896804;16914516;16923326;16968698;17064668;17077126;17081983;17145773;17196961;17214551;17244649;17583407;17599059;17702745;17765681;17804252;17932950;17976533;18006505;18045877;18056264;18218625;18249095;18347018;18363964;18374420;18396277;18426980;18577758;18653540;18669648;18786931;18835169;18838382;18929667;19212140;19269969;19494238;19605563;19651622;19664995;19673492;19713215;19934221;20400958;20460433;20679435;20810653;21148482;21406692;21454492;21542010;21565175;21613211;21685891;21730051;21865595;21989057;22004470;22096251;22298643;22407364;22461490;22475431;22571869;22608513;22661716;22734669;22970203;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23940355;24086303;24259668;24335996;24352656;24378532;24584464;24714562;24715725;24859002;24933155;24960694;24996924;25024229;25211221;25414122;25428919;25505266;25704760;25721503;25795300;25862245;25963737;26129894;26154972;26299518;26529257;26573021;26598554;26887924;26992070;27072905;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27765816;27798618;27806292;27846572;28028151;28108261;28114311;28196833;28446606;28489964;28825699;28832583;28860633;28904123;29089502;29237092;29242379;29358323;29382922;29557506;29789417;30007591;30059200;30061681;30192525;30524438;30853411;31492838;31611695;31844290;31871319;32157095;32203420;32357974;32387766;32502341;32938616;32983136;33141586;33298915;33592498;33912179;33936100;33968037;33981976;34509645;34561969;35051231;35318648;35580925;36010968;36241641;37938771;38665916;39531497;40307207;41350704;7479768;7512369;7559638;7673236;7721814;7753201;7835339;7937899;8021274;8107774;8537347;8543060;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9113980;9268338;9305890;9308960;9405671;9438849;9490638;9497316;9520479;9582072;9659915;9670022;9792683;9796816;9822598;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias, [RefSeq, PubMed]; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results provide evidence that FHL1A interacts with PLEKHG2 and regulates cell morphological change through the activity of PLEKHG2., [RefSeq, PubMed]; Results suggest that FHL1A specifically interacts with PLEKHG2 to regulate a function of PLEKHG2 that is modified by the interaction of Gbetagamma and Galphas., [RefSeq, PubMed]; Role of PLEKHG2 in actin polymerization and clinical and radiological findings in PLEKHG2 deficiency., [RefSeq, PubMed]; Signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018., [RefSeq, PubMed]; The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects in this gene have been associated with leukodystrophy and acquired microcephaly with or without dystonia. [provided by RefSeq, May 2017]., [RefSeq]; This is the first report to show that PLEKHG2 is a novel effector of Galphas, and is negatively regulated by the Galphas subunit through direct interaction., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZK6;C9J0Y4;Q6DHV6;Q96BU2;Q96D18;Q9H699",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0030833 regulation of actin filament polymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 35.6,
        "record_id": "Q9H7P9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14986-1",
        "uniprot_id": [
            {
                "id": "PI51B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14986",
                "type": "external"
            }
        ],
        "mass": 61036.0,
        "length": 540,
        "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta",
        "gene_name": "PIP5K1B",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001265182",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265182",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIP5K1B; STM7",
        "gene_names_refseq": "MSS4; PIP5K1B; STM7",
        "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; 2.7.1.68; PIP5K1-beta; PIP5KIbeta; Phosphatidylinositol 4-phosphate 5-kinase type I beta; Protein STM-7; PtdIns(4)P-5-kinase 1 beta; Type I phosphatidylinositol 4-phosphate 5-kinase beta",
        "protein_names_refseq": "PIP5K1-beta; PIP5KIbeta; phosphatidylinositol 4-phosphate 5-kinase type I beta; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform 3; protein STM-7; ptdIns(4)P-5-kinase 1 beta; type I phosphatidylinositol 4-phosphate 5-kinase beta",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:8395);  (R-HSA-1660499);  (R-HSA-201688);  (R-HSA-6811558)",
        "pathway_count": 4,
        "publication_count": 140,
        "publication_id_list": "10194451;10224048;10517632;10535959;10555148;10559940;10593988;10698942;10753883;10805725;10822173;11001876;11084340;11237011;11279162;11302699;11349134;11425858;11604140;11676921;11733541;11818547;11877430;11923287;12101241;12118066;12324459;12422219;12536145;12556519;12646134;12808147;12847086;1325671;14516276;14617813;14660569;15080793;15107860;15135396;15459103;15464023;15716355;15797027;15840652;16154996;16399794;16456541;16476736;16522682;16914545;16965538;16979564;17008356;17200115;17245604;17569865;17651088;18093523;18753295;18772438;19038970;19553680;19561074;19576174;19896968;20534812;21204784;21285348;22037487;22647598;23519112;23552101;23758345;23909401;24715725;25495341;25713054;25892735;26154972;26992070;27600516;28121444;28218747;28228285;28832583;28834231;29242379;29557506;29632711;29769354;30429286;30524438;31154438;31217245;31844290;31998317;32357974;32387766;32502341;32938616;33717175;33968037;33981976;34087483;34185709;34509645;34932366;35051231;36010968;36215666;36284347;37938771;38350542;7608176;7624799;7744250;8681945;8723348;8769125;8841185;8955136;9094719;9113989;9177790;9192851;9211928;9214626;9286278;9295334;9367159;9428629;9514948;9516481;9524259;9593664;9660759;9660833;9811831;9830063",
        "class_list": "",
        "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that type I phosphatidylinositol 4-phosphate 5-kinase PIP5KIbeta mutants whose dimerization was impaired showed a severe decrease in PI(4,5)P2 production and plasma membrane delocalization., [RefSeq, PubMed]; Knockdown of PIP5K1B in fibroblasts reproduced abnormal actin cytoskeleton remodeling evidenced in Friedreich's ataxia patient cells., [RefSeq, PubMed]; LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9L9;B4DIG7;P78518;P78519;Q5T5K6;Q5T5K8;Q5T5K9;Q5VZ00;Q7KYT5;Q8NHQ5;Q92749",
        "ec_number_list": [
            {
                "id": "2.7.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68",
                "type": "external"
            },
            {
                "id": "2.7.1.149",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0052810 1-phosphatidylinositol-5-kinase activity;GO:0005524 ATP binding;GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0052742 phosphatidylinositol kinase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0001931 uropod",
        "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006661 phosphatidylinositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0009966 regulation of signal transduction;GO:0046488 phosphatidylinositol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.1,
        "record_id": "O14986-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99541-1",
        "uniprot_id": [
            {
                "id": "PLIN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99541",
                "type": "external"
            }
        ],
        "mass": 48075.0,
        "length": 437,
        "protein_name": "Perilipin-2",
        "gene_name": "PLIN2",
        "organism": "Human",
        "refseq_name": "perilipin-2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001113",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001113",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLIN2; ADFP",
        "gene_names_refseq": "ADFP; ADRP; PLIN2",
        "protein_names_uniprotkb": "Perilipin-2; ADRP; Adipophilin; Adipose differentiation-related protein",
        "protein_names_refseq": "adipophilin; adipose differentiation-related protein; perilipin-2 isoform 1",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:123);  (R-HSA-1989781);  (R-HSA-9613354);  (R-HSA-9613829);  (R-HSA-9615710);  (R-HSA-9841922)",
        "pathway_count": 6,
        "publication_count": 169,
        "publication_id_list": "10425206;10558993;10777541;10835357;10882139;11027271;11082038;11237011;11267664;12118000;12177166;12505311;12582161;12829629;1310260;15067378;15130092;15635043;16380219;16972786;17074750;17761950;18540824;18644871;18719978;18848529;18991276;19043829;19088433;19172745;19710929;19934321;20110263;20112406;20375178;20797626;21238931;21282471;2204156;22223895;22544926;22869377;23186163;23481700;24196956;24397554;24714562;24715725;25548167;25576301;25645385;25961502;26118642;26154972;26357594;26375851;26728094;26811146;26902588;26992070;27397612;27600516;27846572;27862975;27920218;2799391;28063628;28218747;28228285;28832583;28904123;29242379;29331515;29393594;29437277;29485866;29493099;29508533;29557506;29626215;29632046;29632711;29786170;29789417;30192525;30315122;30410026;30418433;30425097;30429286;30524438;30573663;30779550;30833945;31154438;31217245;31222486;31530632;31717259;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33329381;33392160;33691108;33912179;33936100;33968037;33981976;34077757;34078123;34087483;34171305;34185709;34211107;34357683;34509645;34561969;34929314;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36215666;36241641;36284347;36581221;37781924;37787446;37938771;38141848;38253038;38561354;38650174;38665916;39302247;40596516;7685352;7892212;8521497;8521498;8647822;8662539;9003395;9012850;9038169;9065481;9151685;9171241;9744270;9748239",
        "class_list": "",
        "function": "Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age-dependent fashion and induces cell senescence via GDF15., [RefSeq, PubMed]; Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via beta-Klotho and perilipin 2., [RefSeq, PubMed]; Perilipin 2-positive mononuclear phagocytes accumulate in the diabetic retina and promote PPARgamma-dependent vasodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets., [UniProtKB, PubMed]; TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2. Publication Status: Online-Only, [RefSeq, PubMed]; The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role., [RefSeq, PubMed]; The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BSC3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol",
        "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0010890 positive regulation of triglyceride storage;GO:0019915 lipid storage;GO:1905691 lipid droplet disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 17.2,
        "record_id": "Q99541-1",
        "record_type": "protein",
        "filter_code": "1000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P1J6-1",
        "uniprot_id": [
            {
                "id": "PLB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P1J6",
                "type": "external"
            }
        ],
        "mass": 163081.0,
        "length": 1458,
        "protein_name": "Phospholipase B1, membrane-associated",
        "gene_name": "PLB1",
        "organism": "Human",
        "refseq_name": "phospholipase B1, membrane-associated isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001164056",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164056",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLB1; PLB",
        "gene_names_refseq": "PLB/LIP; PLB1; PLB",
        "protein_names_uniprotkb": "Phospholipase B1, membrane-associated; 3.1.1.3; 3.1.1.4; 3.1.1.5; Lysophospholipase; PLB/LIP; Phospholipase A2; Phospholipase B/lipase; Phospholipase B; Triacylglycerol lipase; hPLB",
        "protein_names_refseq": "lysophospholipase; phospholipase A2; phospholipase B/lipase; phospholipase B1, membrane-associated isoform 2 precursor; phospholipase B1, membrane-associated; triacylglycerol lipase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151056);  (R-HSA-1482788);  (R-HSA-975634)",
        "pathway_count": 3,
        "publication_count": 91,
        "publication_id_list": "10052934;10085124;10092647;10336645;10358058;10455175;10681567;10769148;11031251;11060341;11112443;11181758;11237011;11274389;11830583;12150957;12161451;12359733;12522102;1279089;14709560;15358783;1542003;15583000;15695510;15863501;15944408;1618844;16200213;16243729;16704971;16864775;16939223;17182612;17525477;17644776;18087047;18195019;18295589;18458083;18460466;18507396;1856611;18614531;18772128;19014918;19019078;1904318;19139408;19501189;20705608;21106934;21515882;21851338;24106281;24520335;26463208;26992070;2793848;28104536;2925608;29557506;32157095;32387766;33912179;33968037;34087483;34171305;35051231;35494241;35580925;3714052;3942763;4345202;5057882;5675424;6420172;6961410;7060561;7683668;8017323;8083230;8300559;8384721;8728311;9188469;9417066;9705332;9888420;9920938;9925661",
        "class_list": "",
        "function": "Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification of epidermis as a site of expression, [RefSeq, PubMed]; PLB1 is a candidate risk gene for rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Rs117512489 in gene phospholipase B1 gene is associated with Non-Small Cell Lung Cancer., [RefSeq, PubMed]; This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 14,
        "predicted_n_glycosites": 13,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 75,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAX2;Q53S03;Q8IUP7;Q96DP9",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.116",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116",
                "type": "external"
            },
            {
                "id": "2.3.1.149",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149",
                "type": "external"
            },
            {
                "id": "3.1.1.111",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0004620 phospholipase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0031526 brush border membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0001523 retinoid metabolic process;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0046340 diacylglycerol catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q6P1J6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q75T13-1",
        "uniprot_id": [
            {
                "id": "PGAP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q75T13",
                "type": "external"
            }
        ],
        "mass": 105383.0,
        "length": 922,
        "protein_name": "GPI inositol-deacylase",
        "gene_name": "PGAP1",
        "organism": "Human",
        "refseq_name": "GPI inositol-deacylase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001308028",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308028",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGAP1; PRO9822",
        "gene_names_refseq": "Bst1; ISPD3024; MRT42; NEDDSBA; PGAP1; SPG67",
        "protein_names_uniprotkb": "GPI inositol-deacylase; 3.1.-.-; Post-GPI attachment to proteins factor 1; hPGAP1",
        "protein_names_refseq": "GPI inositol-deacylase isoform 2; GPI inositol-deacylase; post-GPI attachment to proteins 1; post-GPI attachment to proteins factor 1",
        "tax_id": 9606,
        "disease": "holoprosencephaly (Disease Ontology:DOID:4621); intellectual disability, autosomal recessive 42 (MONDO:MONDO:0014348)",
        "pathway": " (hsa:80055);  (R-HSA-162791)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11483512;12802054;12975309;14734546;24190977;24482476;24784135;25576301;25804403;25823418;25892735;26050939;26992070;27600516;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29671580;29769354;30315122;30429286;30779550;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32938616;33392160;33592498;33912179;33968037;34171305;34357683;34405274;35051231;35580925;35686740;36010968;36241641;37074911;37691099;37938771;38167496;9356492",
        "class_list": "glycogene",
        "function": "Downregulation of lncRNA NEAT1 interacts with miR-374b-5p/PGAP1 axis to aggravate the development of osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]; GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI-anchored protein (GPI-AP) in the endoplasmic reticulum (PubMed:24784135, PubMed:38167496). Initiates the post-attachment remodeling phase of GPI-AP biogenesis and participates in endoplasmic reticulum (ER)-to-Golgi transport of GPI-anchored protein (PubMed:24784135, PubMed:38167496)., [UniProtKB, PubMed, PubMed]; LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis., [RefSeq, PubMed]; Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; PGAP1 encoded an ER-associated, 922-amino acid membrane protein bearing a lipase consensus motif., [RefSeq, PubMed]; PGAP1 mutation and a proven functional loss of PGAP1 were found in a patient with cerebral visual impairment and intellectual diasability., [RefSeq, PubMed]; Study confirms homozygous loss-of function mutations in PGAP1 as a cause of severe encephalopathy., [RefSeq, PubMed]; The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause an autosomal recessive form of cognitive impairment. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1064,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4G0R8;Q4ZG47;Q53SM0;Q6AW92;Q6UWV4;Q9HA24",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0160215 deacylase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0015031 protein transport;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q75T13-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000000000.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96M98-1",
        "uniprot_id": [
            {
                "id": "PACRG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96M98",
                "type": "external"
            }
        ],
        "mass": 33342.0,
        "length": 296,
        "protein_name": "Parkin coregulated gene protein",
        "gene_name": "PACRG",
        "organism": "Human",
        "refseq_name": "parkin coregulated gene protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001073847",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073847",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PACRG; GLUP",
        "gene_names_refseq": "BUG21; GLUP; HAK005771; PACRG2.1; PACRG; PARK2CRG; pf12",
        "protein_names_uniprotkb": "Parkin coregulated gene protein; Molecular chaperone/chaperonin-binding protein; PARK2 coregulated gene protein",
        "protein_names_refseq": "PARK2 co-regulated; PARK2 coregulated; molecular chaperone/chaperonin-binding protein; parkin co-regulated gene protein; parkin coregulated gene protein isoform 2",
        "tax_id": 9606,
        "disease": "leprosy (Disease Ontology:DOID:1024)",
        "pathway": " (hsa:135138)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;12547187;14532270;14737177;31154438;32747620;33529594;35051231;36191189",
        "class_list": "",
        "function": "Associations of PRKN-PACRG SNPs and G x G and G x E interactions with the risk of hyperlipidaemia. Publication Status: Online-Only, [RefSeq, PubMed]; Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding., [RefSeq, PubMed]; Glup/PACRG forms a large molecular chaperone complex, suppresses cell death induced by accumulation of unfolded Pael receptor, facilitates the formation of Pael-R inclusions,and is a component of Lewy bodies in Parkinson's disease, [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin) (PubMed:14532270). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (PubMed:14532270). May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (PubMed:14532270)., [UniProtKB, PubMed, PubMed]; PACRG is linked to parkin via a bi-directional promoter, [RefSeq, PubMed]; This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5B5;Q6IMB8;Q8IZM1;Q8NHP5;Q9H1V9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0051087 protein-folding chaperone binding;GO:0001664 G protein-coupled receptor binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005829 cytosol;GO:0043005 neuron projection;GO:0044297 cell body",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0034620 cellular response to unfolded protein",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q96M98-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60683-1",
        "uniprot_id": [
            {
                "id": "PEX10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60683",
                "type": "external"
            }
        ],
        "mass": 37069.0,
        "length": 326,
        "protein_name": "Peroxisome biogenesis factor 10",
        "gene_name": "PEX10",
        "organism": "Human",
        "refseq_name": "peroxisome biogenesis factor 10 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_002608",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002608",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX10; RNF69",
        "gene_names_refseq": "NALD; PBD6A; PBD6B; PEX10; RNF69",
        "protein_names_uniprotkb": "Peroxisome biogenesis factor 10; 2.3.2.27; Peroxin-10; Peroxisomal biogenesis factor 10; Peroxisome assembly protein 10; RING finger protein 69",
        "protein_names_refseq": "RING finger protein 69; peroxin 10; peroxisome assembly protein 10; peroxisome biogenesis factor 10 isoform 2; peroxisome biogenesis factor 10",
        "tax_id": 9606,
        "disease": "peroxisome biogenesis disorder 6A (Disease Ontology:DOID:0080481); Peroxisome biogenesis disorder 6B (Disease Ontology:DOID:0081435); peroxisomal disease (Disease Ontology:DOID:906)",
        "pathway": " (hsa:5192);  (R-HSA-8866654);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "10022913;10562279;10673331;10704444;11101887;11237011;11390669;11546814;11740563;11781871;11931631;12456682;12559034;12578380;12717447;12885776;15215855;15215856;15545321;15858711;16307923;16854980;16868077;17007944;17041890;17081983;17108083;17130289;17726030;18316726;18359941;18712838;18719106;19105186;19197237;19208625;19410543;19584060;19632994;19723507;20178365;20695019;21203937;21329877;21396873;21554508;21976670;21980954;22002062;22021426;22057399;22371489;22747494;23963456;24235149;24662292;24807418;24865970;24979766;25016021;25030448;25170678;25538232;25854684;25936802;26086376;26138649;26210183;26216882;26220973;26344566;26350214;26711259;26992070;27230853;27569044;27597759;27798111;27846572;28521612;28611990;28765278;28784167;28787099;28904123;30022445;30863997;31844290;31848261;32069232;32157095;32387766;32488085;33784440;33968037;35051231;7719337;7790377;8625414;8824437;8858165;8991089;9090381;9090382;9090383;9539740;9653144;9668159;9683594;9700193;9837948;9922452",
        "class_list": "",
        "function": "Collectively, the rs2477686 in PEX10 , rs6080550 in SIRPA-SIRPG, and rs10842262 in SOX5 gene may indeed be the genetic risk factors for nonobstructive azoospermia (NOA), which requires further investigation using larger independent sets of samples in different ethnic populations., [RefSeq, PubMed]; E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort., [RefSeq, PubMed]; This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWD8;Q5T095;Q9BW90",
        "ec_number_list": [
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77",
                "type": "external"
            },
            {
                "id": "2.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "1.14.11.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42",
                "type": "external"
            },
            {
                "id": "1.3.3.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "3.4.24.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56",
                "type": "external"
            },
            {
                "id": "1.4.3.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3",
                "type": "external"
            },
            {
                "id": "2.6.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51",
                "type": "external"
            },
            {
                "id": "2.6.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44",
                "type": "external"
            },
            {
                "id": "2.3.1.176",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "4.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4",
                "type": "external"
            },
            {
                "id": "2.3.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137",
                "type": "external"
            },
            {
                "id": "2.3.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7",
                "type": "external"
            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.5.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.4.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.184",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
                "type": "external"
            },
            {
                "id": "1.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38",
                "type": "external"
            },
            {
                "id": "1.3.1.124",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124",
                "type": "external"
            },
            {
                "id": "1.1.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15",
                "type": "external"
            },
            {
                "id": "1.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1",
                "type": "external"
            },
            {
                "id": "1.5.3.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7",
                "type": "external"
            },
            {
                "id": "5.1.99.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4",
                "type": "external"
            },
            {
                "id": "4.1.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63",
                "type": "external"
            },
            {
                "id": "1.2.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008320 protein transmembrane transporter activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane",
        "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0007031 peroxisome organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0034614 cellular response to reactive oxygen species",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "O60683-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43088-1",
        "uniprot_id": [
            {
                "id": "PF2R_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43088",
                "type": "external"
            }
        ],
        "mass": 40055.0,
        "length": 359,
        "protein_name": "Prostaglandin F2-alpha receptor",
        "gene_name": "PTGFR",
        "organism": "Human",
        "refseq_name": "prostaglandin F2-alpha receptor isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_000950",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000950",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTGFR",
        "gene_names_refseq": "FP; PTGFR",
        "protein_names_uniprotkb": "Prostaglandin F2-alpha receptor; PGF receptor; PGF2-alpha receptor; Prostanoid FP receptor",
        "protein_names_refseq": "FP prostanoid receptor; PGF receptor; PGF2 alpha receptor; prostaglandin F2-alpha receptor isoform a precursor; prostaglandin F2-alpha receptor; prostaglandin receptor (2-alpha); prostanoid FP receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5737);  (R-HSA-391908);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 52,
        "publication_id_list": "10036181;10191087;10567430;10634944;10727532;10861009;11015615;11237011;11740958;11742120;11753430;12120503;12222762;12466225;12519077;14984197;15464062;15951850;16182515;16268778;16339447;16754659;16923326;18434541;18515384;18577758;18587449;18936096;1905813;2171039;2841328;28584054;29773555;3086311;32938616;34174923;37160891;37217939;7532011;7642548;7883006;7937899;8078484;8117308;8163486;8253813;8300593;8664309;9305846;9341156;9462300;9770463",
        "class_list": "",
        "function": "Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha), [RefSeq, PubMed]; Data, including data from studies using transgenic mice, suggest that signaling via prostaglandin-F2alpha/PTGFR and Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in regulation of hepatic gluconeogenesis in both obesity and fasting. (PTGFR = prostaglandin F2alpha receptor; Camk2g = calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38 MAP kinase; Foxo1 = forkhead box transcription factor O1), [RefSeq, PubMed]; Ligand-induced activation and G protein coupling of prostaglandin F2alpha receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost., [UniProtKB, PubMed]; Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9Y0;Q2KHP3;Q6RYQ6;Q9P1X4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004958 prostaglandin F receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "P43088-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NUJ7-1",
        "uniprot_id": [
            {
                "id": "PLCX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NUJ7",
                "type": "external"
            }
        ],
        "mass": 36668.0,
        "length": 323,
        "protein_name": "PI-PLC X domain-containing protein 1",
        "gene_name": "PLCXD1",
        "organism": "Human",
        "refseq_name": "PI-PLC X domain-containing protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_060860",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060860",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCXD1",
        "gene_names_refseq": "LL0XNC01-136G2.1; PLCXD1",
        "protein_names_uniprotkb": "PI-PLC X domain-containing protein 1",
        "protein_names_refseq": "PI-PLC X domain-containing protein 1 isoform 1; PI-PLC X domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55344)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;22732399;23481700;25418920;25880248;26992070;28218747;28228285;28514659;28904123;29242379;29437277;29557506;29786170;30315122;30410026;31217245;31844290;32350084;32357974;32387766;32938616;33141586;33691108;33912179;33936100;34171305;34357683;34509645;34932366;35051231;35251023;35580925",
        "class_list": "",
        "function": "This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BH51;A2BH52",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9NUJ7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O94880-3",
        "uniprot_id": [
            {
                "id": "PHF14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O94880",
                "type": "external"
            }
        ],
        "mass": 106986.0,
        "length": 948,
        "protein_name": "PHD finger protein 14",
        "gene_name": "PHF14",
        "organism": "Human",
        "refseq_name": "PHD finger protein 14 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_055475",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055475",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF14; KIAA0783",
        "gene_names_refseq": "PHF14",
        "protein_names_uniprotkb": "PHD finger protein 14",
        "protein_names_refseq": "PHD finger protein 14 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9678)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "17081983;18669648;19690332;20068231;21406692;23186163;23481700;23688586;24275569;26866982;27600516;27920218;28160558;28228285;28832583;28834231;29242379;29351928;29393594;30833945;30940184;31848261;32161166;32596345;34019948;35074497;36124662;37768180;38665916",
        "class_list": "",
        "function": "High PHF14 expression is associated with lung cancer., [RefSeq, PubMed]; Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; PHF14 Promotes Cell Proliferation and Migration through the AKT and ERK1/2 Pathways in Gastric Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; PHF14 knockdown causes apoptosis by inducing DNA damage and impairing the activity of the damage response complex in colorectal cancer. Erratum:[Cancer Lett. 2023 Aug 1;568:216290. doi: 10.1016/j.canlet.2023.216290. PMID: 37438200], [RefSeq, PubMed]; Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure. Publication Status: Online-Only, [RefSeq, PubMed]; SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by Activating PHF14 Transcription and Wnt/Beta-Catenin Signaling., [RefSeq, PubMed]; Study revealed that miR-590 was shown to directly target PHF14 thus affecting thus affecting bladder neoplasm cellular epithelial-mesenchymal transition. Erratum:[J Exp Clin Cancer Res. 2022 Mar 15;41(1):103. doi: 10.1186/s13046-022-02326-0. PMID: 35292080] Publication Status: Online-Only, [RefSeq, PubMed]; The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFbeta and Hippo pathways., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0U1RRH6;A7MCZ3;B4DI82",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0140566 histone reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0048286 lung alveolus development;GO:0002314 germinal center B cell differentiation;GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "O94880-3",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q969W9-1",
        "uniprot_id": [
            {
                "id": "PMEPA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q969W9",
                "type": "external"
            }
        ],
        "mass": 31609.0,
        "length": 287,
        "protein_name": "Protein TMEPAI",
        "gene_name": "PMEPA1",
        "organism": "Human",
        "refseq_name": "protein TMEPAI isoform d",
        "refseq_ac": [
            {
                "id": "NP_001242905",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242905",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMEPA1; STAG1; TMEPAI",
        "gene_names_refseq": "PMEPA1; STAG1; TMEPAI",
        "protein_names_uniprotkb": "Protein TMEPAI; Prostate transmembrane protein androgen induced 1; Solid tumor-associated 1 protein; Transmembrane prostate androgen-induced protein",
        "protein_names_refseq": "protein TMEPAI isoform d; protein TMEPAI; solid tumor-associated 1 protein; solid tumor-associated gene 1; transmembrane, prostate androgen induced RNA",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); gastric adenocarcinoma (Disease Ontology:DOID:3717); renal cell carcinoma (Disease Ontology:DOID:4450)",
        "pathway": " (hsa:56937);  (R-HSA-2173788)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10519551;10757800;10873380;11158580;11163210;11237011;11278251;11568975;12151385;12519765;12670906;12907594;14701756;14718519;15496141;15781469;16027725;16061177;18703514;19758997;20061380;20129061;20937913;22045334;22344298;24627487;26992070;29485866;29557506;30429286;30833945;31154438;32157095;32161166;32350084;33968037;34087483;34171305;34777336;34932366;35051231;35318648;35497877;35580925;36010968;36284347;37683830;38385084;39894887;9215638;9335507;9856985",
        "class_list": "",
        "function": "Exploring the role of PMEPA1 in gastric cancer., [RefSeq, PubMed]; Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases., [RefSeq, PubMed]; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514)., [UniProtKB, PubMed, PubMed, PubMed]; METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; PMEPA1 negatively regulates growth of androgen responsive or refractory prostate cancer cells, and these functions may be mediated through the interaction of PMEPA1 with the NEDD4 protein., [RefSeq, PubMed]; This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TDR6;Q8NER4;Q96B72;Q9UJD3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050699 WW domain binding;GO:0070412 R-SMAD binding;GO:0140311 protein sequestering activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0030521 androgen receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392 negative regulation of SMAD protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q969W9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q68DY9-1",
        "uniprot_id": [
            {
                "id": "ZN772_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q68DY9",
                "type": "external"
            }
        ],
        "mass": 55367.0,
        "length": 489,
        "protein_name": "Zinc finger protein 772",
        "gene_name": "ZNF772",
        "organism": "Human",
        "refseq_name": "zinc finger protein 772 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001019767",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019767",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF772",
        "gene_names_refseq": "ZNF772",
        "protein_names_uniprotkb": "Zinc finger protein 772",
        "protein_names_refseq": "zinc finger protein 772 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:400720);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;2163759;23481700;25418920;25892735;28228285;28832583;29557506;29632711;31217245;31844290;32157095;32385021;32502341;32938616;33592498;33968037;34087483;35580925;36581221;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; [Correlation between DNA Methylation of ZNF772 Promoter Region and Cervical Cancer]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJK9;B4DH56;B4DYS0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q68DY9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00623-1",
        "uniprot_id": [
            {
                "id": "PEX12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00623",
                "type": "external"
            }
        ],
        "mass": 40797.0,
        "length": 359,
        "protein_name": "Peroxisome assembly protein 12",
        "gene_name": "PEX12",
        "organism": "Human",
        "refseq_name": "peroxisome assembly protein 12",
        "refseq_ac": [
            {
                "id": "NP_000277",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000277",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX12; PAF3",
        "gene_names_refseq": "PAF-3; PBD3A; PEX12",
        "protein_names_uniprotkb": "Peroxisome assembly protein 12; PAF-3; Peroxin-12; Peroxisome assembly factor 3",
        "protein_names_refseq": "peroxin 12; peroxisome assembly factor 3; peroxisome assembly protein 12",
        "tax_id": 9606,
        "disease": "peroxisome biogenesis disorder 3A (Disease Ontology:DOID:0080478); peroxisome biogenesis disorder 3B (Disease Ontology:DOID:0081241)",
        "pathway": " (hsa:5193);  (R-HSA-8866654);  (R-HSA-9033241);  (R-HSA-9603798)",
        "pathway_count": 4,
        "publication_count": 166,
        "publication_id_list": "10022913;10430017;10562279;10673331;10704444;11101887;11237011;11390669;11402059;11453642;11546814;11590176;11740563;11781871;11883941;11931631;12456682;12559034;12578380;12717447;12751901;12885776;12924628;14709540;15007061;15215855;15215856;15545321;15713480;15781447;15858711;16280322;16307923;16791427;16854980;16868077;16895967;16980692;17007944;17041890;17069900;17108083;17130289;17534573;17726030;18174172;18316726;18359941;18712838;18719106;18782765;19105186;19197237;19208625;19410543;19584060;19632994;19723507;20178365;20531392;20554521;21102411;21203937;21329877;21396873;21554508;21976670;21980954;22002062;22021426;22057399;22371489;22624858;22747494;23460677;23481700;23628762;23963456;24235149;24662292;24714562;24715725;24807418;24865970;24979766;25016021;25030448;25062251;25170678;25418920;25505266;25517356;25538232;25576301;25645385;25854684;25892735;25936802;26086376;26094004;26138649;26154972;26210183;26216882;26220973;26344566;26350214;26375851;26711259;26728094;26777132;26929215;26947510;26992070;27569044;27597759;27798111;27846572;28218747;28281558;28325759;28521612;28611990;28765278;28787099;28832583;29242379;29437277;29493099;29508533;29769354;30315122;30410026;30833945;31844290;31848261;31998317;32157095;32938616;33123925;33298915;33633747;33717175;34171305;34211107;35051231;36284347;36581221;7719337;7790377;8625414;8824437;8858165;8991089;9090381;9090382;9090383;9090384;9354782;9418908;9539740;9632816;9653144;9668159;9837948;9922452",
        "class_list": "",
        "function": "A founder mutation in PEX12 among Egyptian patients in peroxisomal biogenesis disorder., [RefSeq, PubMed]; Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292, PubMed:9354782, PubMed:9632816). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6M2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0008320 protein transmembrane transporter activity;GO:1990757 ubiquitin ligase activator activity",
        "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0007031 peroxisome organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0034614 cellular response to reactive oxygen species",
        "synthesized_glycan_count": 0,
        "hit_score": 16.7,
        "record_id": "O00623-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q01813-1",
        "uniprot_id": [
            {
                "id": "PFKAP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q01813",
                "type": "external"
            }
        ],
        "mass": 85596.0,
        "length": 784,
        "protein_name": "ATP-dependent 6-phosphofructokinase, platelet type",
        "gene_name": "PFKP",
        "organism": "Human",
        "refseq_name": "ATP-dependent 6-phosphofructokinase, platelet type isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001229268",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229268",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PFKP; PFKF",
        "gene_names_refseq": "ATP-PFK; PFK-C; PFK-P; PFKF; PFKP",
        "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, platelet type; 2.7.1.11; 6-phosphofructokinase type C; ATP-PFK; PFK-C; PFK-P; Phosphofructo-1-kinase isozyme C; Phosphohexokinase",
        "protein_names_refseq": "6-phosphofructokinase type C; 6-phosphofructokinase, platelet type; ATP-dependent 6-phosphofructokinase, platelet type isoform 2; ATP-dependent 6-phosphofructokinase, platelet type; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphohexokinase",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease (Disease Ontology:DOID:2747)",
        "pathway": " (hsa:5214);  (R-HSA-70171)",
        "pathway_count": 2,
        "publication_count": 154,
        "publication_id_list": "10714828;11237011;11371164;11506403;11780755;12616532;1278465;12965206;13538944;14654843;15302935;15592455;15710582;16511037;16964243;17016520;17081983;17322306;17804405;1834056;183598;18669648;18691976;1871135;18767875;18910716;18910717;18927083;19608861;19651622;19664994;19664995;19690332;20058876;20068231;21406692;21586797;22219026;22923583;23168256;23186163;23446454;24366607;2462567;24715725;25418920;25648650;25892735;26154972;26375851;26811146;26853435;26929215;26992070;27846572;27862975;2793178;2846554;28467828;28904123;29038421;29351928;29437277;29493099;29557506;2960695;29677490;30315122;30410026;30484775;30517626;30573663;30779550;30833945;31020640;31092671;31154438;31217245;31222486;31530632;3170585;31844290;31998317;3208766;32157095;32161166;32195176;32265295;32350084;32357974;32387766;32488085;32938616;32983136;33214551;33298915;3355497;33588886;33592498;33607258;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34433824;3453121;34561969;34725712;34782236;34932366;35051231;35154160;35251023;3529090;35318648;35561310;35580925;35917090;36215666;36241641;36284347;37217939;37967006;38086793;38217030;38665916;38982480;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7717389;7825568;7989588;8117307;8325892;8447317;8786021;9438414;9493266",
        "class_list": "glycogene",
        "function": "A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]; Inhibition of PFKP in renal tubular epithelial cell restrains TGF-beta induced glycolysis and renal fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; KLF4 plays a role in maintenance of high glycolytic metabolism by transcriptional activation of the PFKP gene in breast cancer cells., [RefSeq, PubMed]; P53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP., [RefSeq, PubMed]; PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1178,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KS15;Q5VSR7;Q5VSR8",
        "ec_number_list": [
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "Q01813-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B2RU33-1",
        "uniprot_id": [
            {
                "id": "POTEC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B2RU33",
                "type": "external"
            }
        ],
        "mass": 61188.0,
        "length": 542,
        "protein_name": "POTE ankyrin domain family member C",
        "gene_name": "POTEC",
        "organism": "Human",
        "refseq_name": "POTE ankyrin domain family member C isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001131143",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131143",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POTEC; A26B2; POTE18",
        "gene_names_refseq": "A26B2; CT104.6; POTE-18; POTE18; POTEC",
        "protein_names_uniprotkb": "POTE ankyrin domain family member C; ANKRD26-like family B member 2; POTE-18; Prostate, ovary, testis-expressed protein on chromosome 18",
        "protein_names_refseq": "ANKRD26-like family B member 2; POTE ankyrin domain family member C isoform 1; cancer/testis antigen family 104, member 6; prostate, ovary, testis-expressed protein on chromosome 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388468)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;12475935",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "B2RU33-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NSJ2-1",
        "uniprot_id": [
            {
                "id": "PHLB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NSJ2",
                "type": "external"
            }
        ],
        "mass": 71912.0,
        "length": 640,
        "protein_name": "Pleckstrin homology-like domain family B member 3",
        "gene_name": "PHLDB3",
        "organism": "Human",
        "refseq_name": "pleckstrin homology-like domain family B member 3",
        "refseq_ac": [
            {
                "id": "NP_942147",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942147",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHLDB3",
        "gene_names_refseq": "PHLDB3",
        "protein_names_uniprotkb": "Pleckstrin homology-like domain family B member 3",
        "protein_names_refseq": "pleckstrin homology-like domain family B member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653583)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;23481700;25576301;28008906;28904123;29242379;31844290;31848261;32157095;32938616;32983136;33968037;34087483;34357683;34932366;35051231;35318648;35561310",
        "class_list": "",
        "function": "PHLDB3 promotes tumour growth by inactivating p53 in a negative feedback fashion. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N7Z4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6NSJ2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NST1-1",
        "uniprot_id": [
            {
                "id": "PLPL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NST1",
                "type": "external"
            }
        ],
        "mass": 52865.0,
        "length": 481,
        "protein_name": "1-acylglycerol-3-phosphate O-acyltransferase PNPLA3",
        "gene_name": "PNPLA3",
        "organism": "Human",
        "refseq_name": "1-acylglycerol-3-phosphate O-acyltransferase PNPLA3",
        "refseq_ac": [
            {
                "id": "NP_079501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPLA3; ADPN; C22orf20",
        "gene_names_refseq": "ADPN; C22orf20; PNPLA3; iPLA(2)epsilon",
        "protein_names_uniprotkb": "1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; 2.3.1.51; 3.1.1.3; 3.1.1.4; ADPN; Acylglycerol transacylase; Adiponutrin; Calcium-independent phospholipase A2-epsilon; Lysophosphatidic acid acyltransferase; Patatin-like phospholipase domain-containing protein 3; iPLA2-epsilon",
        "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; acylglycerol O-acyltransferase; acylglycerol transacylase; adiponutrin; calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; iPLA2epsilon; lysophosphatidic acid acyltransferase; patatin like phospholipase domain containing 3; patatin-like phospholipase domain-containing protein 3",
        "tax_id": 9606,
        "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypothyroidism (Disease Ontology:DOID:1459); coronary artery disease (Disease Ontology:DOID:3393); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:80339);  (R-HSA-1482883)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "11237011;11481335;14521909;15181042;15272052;15364929;15671038;16106050;18452279;18477386;18728122;18820647;19224197;19738004;19957260;19962385;20034933;20058876;21068004;21878620;22560221;22704398;23010516;23333103;24155878;24269995;24366607;26192236;27288299;29158695;29557506;31844290;32157095;32161166;32387766;32938616;33968037;34019948;38780312;39000384;39042259;39336763;39454357;9756920",
        "class_list": "",
        "function": "A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Ambient air pollution exposure is associated with liver fat and stiffness in Latino youth with a more pronounced effect in those with PNPLA3 genotype and more advanced liver disease., [RefSeq, PubMed]; Epidemiological Study on the Interaction between the PNPLA3 (rs738409) and Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Genotypic variation in CYP2E1, GCKR, and PNPLA3 among nonalcoholic steatohepatitis patients of Turkish origin. Publication Status: Online-Only, [RefSeq, PubMed]; IPLA2epsilon (adiponutrin), iPLA2zeta (TTS-2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols, [RefSeq, PubMed]; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (PubMed:15364929)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The health care experience of adults with metabolic dysfunction-associated steatohepatitis and influence of PNPLA3: A qualitative study. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QYI0;B2RCL3;B3KW00;Q6P1A1;Q96CB4",
        "ec_number_list": [
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "2.3.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.n7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            },
            {
                "id": "3.1.1.116",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0004623 phospholipase A2 activity;GO:0036042 long-chain fatty acyl-CoA binding;GO:0004806 triacylglycerol lipase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0032869 cellular response to insulin stimulus;GO:0050872 white fat cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q9NST1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86V59-1",
        "uniprot_id": [
            {
                "id": "PNM8A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86V59",
                "type": "external"
            }
        ],
        "mass": 48161.0,
        "length": 439,
        "protein_name": "Paraneoplastic antigen-like protein 8A",
        "gene_name": "PNMA8A",
        "organism": "Human",
        "refseq_name": "paraneoplastic antigen-like protein 8A isoform b",
        "refseq_ac": [
            {
                "id": "NP_001096619",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096619",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNMA8A; PNMAL1",
        "gene_names_refseq": "PNMA8A; PNMAL1",
        "protein_names_uniprotkb": "Paraneoplastic antigen-like protein 8A; PNMA-like protein 1",
        "protein_names_refseq": "PNMA-like protein 1; paraneoplastic Ma antigen family like 1; paraneoplastic Ma antigen family member 8A; paraneoplastic antigen-like protein 8A isoform b; paraneoplastic antigen-like protein 8A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55228)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;16550607;28832583;29557506;29786170;30429286;31154438;31222486;31844290;31848261;32157095;32488085;32938616;33936100;33968037;34171305;34405274;35051231;36010968;37938771",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2F3;Q5U638;Q8N3H4;Q9NVE8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q86V59-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH37-1",
        "uniprot_id": [
            {
                "id": "OR4C3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH37",
                "type": "external"
            }
        ],
        "mass": 33726.0,
        "length": 302,
        "protein_name": "Olfactory receptor 4C3",
        "gene_name": "OR4C3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4C3",
        "refseq_ac": [
            {
                "id": "NP_001004702",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004702",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4C3",
        "gene_names_refseq": "OR11-98; OR4C3",
        "protein_names_uniprotkb": "Olfactory receptor 4C3; Olfactory receptor OR11-98",
        "protein_names_refseq": "olfactory receptor 4C3; olfactory receptor OR11-98",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256144);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNF2;Q6IFB3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8NH37-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P49763-1",
        "uniprot_id": [
            {
                "id": "PLGF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P49763",
                "type": "external"
            }
        ],
        "mass": 24789.0,
        "length": 221,
        "protein_name": "Placenta growth factor",
        "gene_name": "PGF",
        "organism": "Human",
        "refseq_name": "placenta growth factor isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001193941",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193941",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGF; PGFL; PLGF",
        "gene_names_refseq": "D12S1900; PGFL; PGF; PIGF; PLGF; PlGF-2; SHGC-10760",
        "protein_names_uniprotkb": "Placenta growth factor; PlGF",
        "protein_names_refseq": "placenta growth factor isoform 2 precursor; placental growth factor, vascular endothelial growth factor-related protein",
        "tax_id": 9606,
        "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); pyelonephritis (Disease Ontology:DOID:11400); limited scleroderma (Disease Ontology:DOID:1577); breast cancer (Disease Ontology:DOID:1612); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); carotid artery disease (Disease Ontology:DOID:3407); renal cell carcinoma (Disease Ontology:DOID:4450); lymphedema (Disease Ontology:DOID:4977); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:5228);  (R-HSA-194313);  (R-HSA-195399)",
        "pathway_count": 3,
        "publication_count": 33,
        "publication_id_list": "11004490;11069911;11237011;11387210;11532940;12871269;12881528;1417831;14568677;16633338;16835467;1924389;21215706;24715725;2479986;31844290;31848261;37938771;38115361;38166739;38217598;38247274;7681160;7824266;7929268;8148155;8617204;8637916;8700872;9207067;9207183;9435229;9722576",
        "class_list": "",
        "function": "Assessment of serum levels and placental bed tissue expression of IGF-1, bFGF, and PLGF in patients with placenta previa complicated with placenta accreta spectrum disorders., [RefSeq, PubMed]; Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth., [UniProtKB, PubMed]; Predictive value of maternal serum placental growth factor levels for discordant fetal growth in twins: a retrospective cohort study. Publication Status: Online-Only, [RefSeq, PubMed]; Serum Placental Growth Factor as a Marker of Cerebrovascular Disease Burden in Alzheimer's Disease., [RefSeq, PubMed]; Serum placental growth factor, total cholesterol, and triglycerides for prediction of intrahepatic cholestasis of pregnancy., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 29,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q07101;Q9BV78;Q9Y6S8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0001666 response to hypoxia",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "P49763-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H307-1",
        "uniprot_id": [
            {
                "id": "PININ_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H307",
                "type": "external"
            }
        ],
        "mass": 81628.0,
        "length": 717,
        "protein_name": "Pinin",
        "gene_name": "PNN",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PNN; DRS; MEMA",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Pinin; 140 kDa nuclear and cell adhesion-related phosphoprotein; DRS protein; DRSP; Desmosome-associated protein; Domain-rich serine protein; Melanoma metastasis clone A protein; Nuclear protein SDK3; SR-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5411);  (R-HSA-72163)",
        "pathway_count": 2,
        "publication_count": 209,
        "publication_id_list": "10095061;10486276;10645008;10809736;10882114;10931946;11014198;11101529;11233976;11237011;11991638;12051732;12176931;12411573;12414731;12477934;12893261;14517304;14578391;14625303;14713954;14729963;15302935;15358154;15542832;15735603;16314458;16565220;16809785;16964243;17081983;17095540;17287340;17332742;17525332;17606899;18212344;18322460;18452278;18593880;18669648;18691976;18707149;18767875;19007248;19103666;19165350;19413330;19536130;19608861;19651622;19664994;19664995;19690332;19691289;20068231;20166139;20230923;20423332;20980672;21406692;21536652;2176635;22110043;22365833;22388736;22424782;22544926;22959432;22961380;23186163;23222130;23236153;23301498;23345524;23481700;24196718;24275569;24304693;24366607;24448447;24715725;24737827;24914973;25114211;25218447;25418920;25555158;25576301;2558966;25645385;25755297;25772364;26024233;26154972;26385511;26420826;26811146;26969736;26992070;27377154;27459055;27543614;27600516;27683217;27862975;27920218;28062851;28063628;28076346;28228285;28502770;28510447;28781166;28832583;28834231;29242379;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;29632711;2963332;29786170;30315122;30315277;30429286;30524438;30705154;30728453;30765414;30779550;30975767;31092671;31154438;31409651;31530632;31575892;31844290;31848261;31937595;31998317;32119511;32157095;32179686;32265295;32329775;32357974;32387766;32488085;32494006;32502341;32897882;32938616;32983136;33141586;33214551;33243851;33298915;33392160;33446560;33465208;33592498;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34229054;34301950;34405274;34509645;34822310;35051231;35251023;35318648;35385551;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37217939;3757028;40596516;40914422;8566756;8608946;8922384;9016565;9242493;9447706;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 32,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZX8;O60899;Q53EM7;Q6P5X4;Q7KYL1;Q99738;Q9UHZ9;Q9UQR9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0043065 positive regulation of apoptotic process;GO:0048255 mRNA stabilization;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 21.2,
        "record_id": "Q9H307-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75151-1",
        "uniprot_id": [
            {
                "id": "PHF2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75151",
                "type": "external"
            }
        ],
        "mass": 120775.0,
        "length": 1096,
        "protein_name": "Lysine-specific demethylase PHF2",
        "gene_name": "PHF2",
        "organism": "Human",
        "refseq_name": "lysine-specific demethylase PHF2",
        "refseq_ac": [
            {
                "id": "NP_005383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF2; CENP-35; KIAA0662",
        "gene_names_refseq": "CENP-35; GRC5; JHDM1E; KDM7C; PHF2",
        "protein_names_uniprotkb": "Lysine-specific demethylase PHF2; 1.14.11.-; GRC5; PHD finger protein 2",
        "protein_names_refseq": "centromere protein 35; jumonji C domain-containing histone demethylase 1E; lysine demethylase 7C; lysine-specific demethylase PHF2",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309)",
        "pathway": " (hsa:5253);  (R-HSA-3214842)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "10.1101/2023.09.13.557529;10051327;11237011;15620353;16362057;16603237;16603238;16732292;16732293;16738407;17081983;17310255;17320163;17351631;17713478;17947579;18452278;18669648;18990233;19413330;19502796;19690332;19727073;19843542;20023638;20068231;20084082;20129925;20208542;20457893;20622853;20622854;20813266;21167174;21406692;21532585;22028470;22615488;23186163;23481700;24275569;24714562;24715725;25576301;25892735;26154972;26728094;26992070;27846572;27862975;27920218;28063628;28228285;28832583;28834231;28855257;29242379;29393594;29493099;29508533;29557506;29563586;29632046;29632711;29769354;29786170;30379171;30429286;30484775;31154438;31844290;31848261;31998317;32119511;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33298915;33968037;34087483;35051231;35494241;35580925;35729160;36010968;36241641;36284347;36380035;36581221;37828054;37938771;38665916;38890452",
        "class_list": "",
        "function": "Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by Sponging miR-873-5p to Release PHF2., [RefSeq, PubMed]; Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; HIF-1alpha-mediated augmentation of miRNA-18b-5p facilitates proliferation and metastasis in osteosarcoma through attenuation PHF2. Publication Status: Online-Only, [RefSeq, PubMed]; Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; PHF2-mediated H3K9me balance orchestrates heterochromatin stability and neural progenitor proliferation., [RefSeq, PubMed]; Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The crystal structures of PHF2 Jumonji domain in the absence and presence of additional exogenous metal ions were determined., [RefSeq, PubMed]; This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VXG0;Q8N3K2;Q9Y6N4",
        "ec_number_list": [
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "1.14.11.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66",
                "type": "external"
            },
            {
                "id": "1.14.11.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65",
                "type": "external"
            },
            {
                "id": "1.14.99.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0003713 transcription coactivator activity;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore",
        "go_biological_process": "GO:0001889 liver development;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006482 protein demethylation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "O75151-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96KN3-1",
        "uniprot_id": [
            {
                "id": "PKNX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96KN3",
                "type": "external"
            }
        ],
        "mass": 52028.0,
        "length": 472,
        "protein_name": "Homeobox protein PKNOX2",
        "gene_name": "PKNOX2",
        "organism": "Human",
        "refseq_name": "homeobox protein PKNOX2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001369252",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001369252",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKNOX2; PREP2",
        "gene_names_refseq": "PKNOX2; PREP2",
        "protein_names_uniprotkb": "Homeobox protein PKNOX2; Homeobox protein PREP-2; PBX/knotted homeobox 2",
        "protein_names_refseq": "PBX/knotted homeobox 2; homeobox protein PKNOX2 isoform a; homeobox protein PKNOX2; homeobox protein PREP-2",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741)",
        "pathway": " (hsa:63876)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;11549286;11972344;29485866;29557506;30429286;30745575;32265295;33968037;35051231;38644381",
        "class_list": "",
        "function": "Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]., [RefSeq]; PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; PKNOX2 is a tumor suppressor in gastric cancer by activation of IGFBP5 and p53 signaling pathways, [RefSeq, PubMed]; This novel PKNOX-related protein may interact with PBX proteins and play a role in tissue-specific regulation of transcription., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z5I5;F5GZ15;Q63HL6;Q86XD1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003785 actin monomer binding;GO:0051015 actin filament binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q96KN3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NBL1-1",
        "uniprot_id": [
            {
                "id": "PGLT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NBL1",
                "type": "external"
            }
        ],
        "mass": 46189.0,
        "length": 392,
        "protein_name": "Protein O-glucosyltransferase 1",
        "gene_name": "POGLUT1",
        "organism": "Human",
        "refseq_name": "protein O-glucosyltransferase 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_689518",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689518",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POGLUT1; C3orf9; CLP46; KTELC1; MDS010; MDSRP; PRO1006",
        "gene_names_refseq": "C3orf9; CLP46; KDELCL1; KTELC1; LGMD2Z; LGMDR21; MDS010; MDSRP; POGLUT1; Rumi; hCLP46",
        "protein_names_uniprotkb": "Protein O-glucosyltransferase 1; 2.4.1.376; 2.4.2.63; CAP10-like 46 kDa protein; KTEL motif-containing protein 1; Myelodysplastic syndromes relative protein; O-glucosyltransferase Rumi homolog; Protein O-xylosyltransferase POGLUT1; hCLP46; hRumi",
        "protein_names_refseq": "9630046K23Rik; CAP10-like 46 kDa protein; KDELC family like 1; KTEL (Lys-Tyr-Glu-Leu) containing 1; KTEL motif-containing protein 1; O-glucosyltransferase Rumi homolog; hRumi; myelodysplastic syndromes relative protein; protein O-glucosyltransferase 1 precursor; protein O-xylosyltransferase POGLUT1; x 010 protein",
        "tax_id": 9606,
        "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256); autosomal recessive limb-girdle muscular dystrophy type 2Z (Disease Ontology:DOID:0080762); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274)",
        "pathway": " (hsa:56983);  (R-HSA-1912399)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11524432;12486116;12975309;15340161;15692013;16303743;16524674;18243100;18347015;19822096;20068231;20143914;20664185;21081508;21464368;21490058;21949356;21971768;23090970;23481700;24190977;24366607;24387993;25880248;27479915;27807076;28775322;28832583;28904123;29242379;29508533;29557506;29741879;29878302;29953591;30643196;30653241;31611695;31844290;31848261;31897643;32157095;32161166;32938616;32983136;33298915;33691108;33912179;34019948;34087483;34171305;34725712;35051231;35138101;35154160;35251023;35289036;35580925;37074911;38665916;40596516",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Altered C3ORF9 expression in myelodysplastic syndrome was possibly due to different gene regulation in these patients and/or to the increased CD34+ cells. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; CLP46 was overexpressed in AML, T-ALL, and leukemic cell lines. Considering that CLP46 has the capability of modifying the Notch pathway, our finding adds weight to the possible importance of Notch signaling in the pathogenesis of AML and T-ALL., [RefSeq, PubMed]; Case Report: Japanese female with Galli-Galli Disease due to novel POGLUT1 mutation., [RefSeq, PubMed]; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; POGLUT1 biallelic mutations cause myopathy with reduced satellite cells, alpha-dystroglycan hypoglycosylation and a distinctive radiological pattern., [RefSeq, PubMed]; RUMI is a novel negative prognostic factor with significant therapeutic potential in non-small-cell lung cancer., [RefSeq, PubMed]; This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]., [RefSeq]; This is the first study to demonstrate that POGLUT1 and not CD80 is the effector gene regulated by the primary functional SNP rs2293370, and that increased expression of POGLUT1 might be involved in the pathogenesis of Primary biliary cholangitis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 464,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 22,
        "disease_count": 3,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD13;Q53GJ4;Q8N2T1",
        "ec_number_list": [
            {
                "id": "2.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-",
                "type": "external"
            },
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
                "type": "external"
            },
            {
                "id": "2.4.1.376",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.376",
                "type": "external"
            },
            {
                "id": "2.4.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.63",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0006493 protein O-linked glycosylation;GO:0045747 positive regulation of Notch signaling pathway;GO:0007369 gastrulation;GO:0060537 muscle tissue development",
        "synthesized_glycan_count": 6710,
        "hit_score": 9.1,
        "record_id": "Q8NBL1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z3Z4-1",
        "uniprot_id": [
            {
                "id": "PIWL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z3Z4",
                "type": "external"
            }
        ],
        "mass": 96589.0,
        "length": 852,
        "protein_name": "Piwi-like protein 4",
        "gene_name": "PIWIL4",
        "organism": "Human",
        "refseq_name": "piwi-like protein 4",
        "refseq_ac": [
            {
                "id": "NP_689644",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689644",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIWIL4; HIWI2; PIWI",
        "gene_names_refseq": "HIWI2; MIWI2; PIWIL4",
        "protein_names_uniprotkb": "Piwi-like protein 4",
        "protein_names_refseq": "piwi-like 4; piwi-like protein 4; testis tissue sperm-binding protein Li 85P",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:143689);  (R-HSA-5601884);  (R-HSA-9845323)",
        "pathway_count": 3,
        "publication_count": 33,
        "publication_id_list": "11237011;12906857;17544373;18922463;21465557;22233380;22483988;23056369;23826142;23980886;24656595;24969058;25038252;26992070;27543614;28025795;28711973;29557506;30145353;30226541;31222486;31844290;32161174;32372724;32387766;33141586;33592498;33912179;34509645;35051231;35074406;37146239;38359823",
        "class_list": "",
        "function": "A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. Erratum:[Blood. 2024 Jan 11;143(2):184. doi: 10.1182/blood.2023023247. PMID: 38206638], [RefSeq, PubMed]; HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis., [RefSeq, PubMed]; PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. Publication Status: Online-Only, [RefSeq, PubMed]; PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]., [RefSeq]; PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells, [RefSeq, PubMed]; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (By similarity). The PIWIL4-piRNA pathway acts in the nucleus and mediates silencing of active transposons: engages with nascent transposable element transcripts and governs the piRNA-directed DNA methylation and subsequent repression of transposons (By similarity). In contrast to PIWIL1 and PIWIL2, does not show endonuclease activity (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities (By similarity). Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells., [RefSeq, PubMed]; These findings revealed that Piwil4 is a novel regulator of ER signaling that could be targeted to inhibit breast cancer growth and migration., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DEG5;Q68CZ4;Q8N8G9;Q8N9V8;Q8NEH2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071547 piP-body;GO:0043186 P granule",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0010669 epithelial structure maintenance",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q7Z3Z4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12955-1",
        "uniprot_id": [
            {
                "id": "PEPD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12955",
                "type": "external"
            }
        ],
        "mass": 54548.0,
        "length": 493,
        "protein_name": "Xaa-Pro dipeptidase",
        "gene_name": "PEPD",
        "organism": "Human",
        "refseq_name": "xaa-Pro dipeptidase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000276",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000276",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEPD; PRD",
        "gene_names_refseq": "PEPD; PROLIDASE",
        "protein_names_uniprotkb": "Xaa-Pro dipeptidase; 3.4.13.9; Imidodipeptidase; Peptidase D; Prolidase; Proline dipeptidase; X-Pro dipeptidase",
        "protein_names_refseq": "X-Pro dipeptidase; aminoacyl-L-proline hydrolase; imidodipeptidase; proline dipeptidase; testicular tissue protein Li 138; xaa-Pro dipeptidase isoform 1; xaa-Pro dipeptidase",
        "tax_id": 9606,
        "disease": "prolidase deficiency (Disease Ontology:DOID:0111540); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)",
        "pathway": " (hsa:5184)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "11237011;11840567;12384772;15302935;17081196;22223895;23301498;23481700;2365824;24275569;24714562;24715725;25576301;26154972;26375851;26728094;26853435;26992070;27600516;27846572;27862975;27920218;28677335;28832583;28834231;28904123;29242379;2925654;29493099;29508533;29557506;29632711;29786170;29789417;30315122;30410026;30429286;31020640;31154438;31844290;32157095;32350084;32357974;32488085;32502341;32938616;32983136;33043033;33298915;33537174;33592498;33968037;34171305;34229054;34357683;34725712;35051231;35138101;35165443;35580925;36010968;36284347;36521400;36591822;37938771;38159857;38665916;8198124;8900231",
        "class_list": "",
        "function": "Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; KLF6 activates Sp1-mediated prolidase transcription during TGF-beta1 signaling. Erratum:[J Biol Chem. 2025 Mar;301(3):108214. doi: 10.1016/j.jbc.2025.108214. PMID: 39952079], [RefSeq, PubMed]; Prolidase as a marker of fibrogenesis in idiopathic primary ovarian insufficiency., [RefSeq, PubMed]; The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia., [RefSeq, PubMed]; This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3Z1;A8K416;A8K696;A8MX47;B4DDB7;B4DGJ1;E9PCE8;Q8TBN9;Q9BT75",
        "ec_number_list": [
            {
                "id": "3.4.13.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.9",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity;GO:0102009 proline dipeptidase activity",
        "go_cellular_component": "GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0006520 amino acid metabolic process;GO:0030574 collagen catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "P12955-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H720-1",
        "uniprot_id": [
            {
                "id": "PG2IP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H720",
                "type": "external"
            }
        ],
        "mass": 78584.0,
        "length": 699,
        "protein_name": "PGAP2-interacting protein",
        "gene_name": "CWH43",
        "organism": "Human",
        "refseq_name": "PGAP2-interacting protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001273720",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273720",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CWH43; PGAP2IP",
        "gene_names_refseq": "CWH43-C; CWH43; PGAP2IP",
        "protein_names_uniprotkb": "PGAP2-interacting protein; Cell wall biogenesis protein 43 C-terminal homolog",
        "protein_names_refseq": "PGAP2-interacting protein isoform 2; PGAP2-interacting protein; cell wall biogenesis protein 43 C-terminal homolog",
        "tax_id": 9606,
        "disease": "normal pressure hydrocephalus (Disease Ontology:DOID:1572)",
        "pathway": " (hsa:80157)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;23481700;25418920;26929215;29557506;29789417;31844290;32502341;34380733;37894942",
        "class_list": "",
        "function": "CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus., [RefSeq, PubMed]; Involved in lipid remodeling during GPI-anchor maturation., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPD7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane",
        "go_biological_process": "GO:0006506 GPI anchor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9H720-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96FM1-1",
        "uniprot_id": [
            {
                "id": "PGAP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96FM1",
                "type": "external"
            }
        ],
        "mass": 36475.0,
        "length": 320,
        "protein_name": "GPI-specific phospholipase A2-like PGAP3",
        "gene_name": "PGAP3",
        "organism": "Human",
        "refseq_name": "GPI-specific phospholipase A2-like PGAP3 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001278655",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278655",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGAP3; CAB2; PERLD1; PRO1100",
        "gene_names_refseq": "AGLA546; CAB2; PERLD1; PGAP3; PP1498; hCOS16",
        "protein_names_uniprotkb": "GPI-specific phospholipase A2-like PGAP3; 3.1.1.-; COS16 homolog; Gene coamplified with ERBB2 protein; PER1-like domain-containing protein 1; Post-GPI attachment to proteins factor 3; hCOS16",
        "protein_names_refseq": "COS16 homolog; GPI-specific phospholipase A2-like PGAP3 isoform 2 precursor; GPI-specific phospholipase A2-like PGAP3; gene coamplified with ERBB2 protein; per1-like domain containing 1; post-GPI attachment to proteins 3; post-GPI attachment to proteins factor 3",
        "tax_id": 9606,
        "disease": "hyperphosphatasia with impaired intellectual development syndrome (Disease Ontology:DOID:0070431); hyperphosphatasia with impaired intellectual development syndrome 4 (Disease Ontology:DOID:0070436); chronic asthma (Disease Ontology:DOID:0080809); allergic asthma (Disease Ontology:DOID:9415)",
        "pathway": " (hsa:93210)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12460457;12739007;12975309;15010812;16303743;17021251;24190977;24439110;25418920;25880248;28446606;28832583;29620724;29741879;30429286;31844290;32161166;32357974;32387766;32938616;33591461;33592498;34051734;35051231;35580925;36010968;36215666;36241641;36284347;37074911;37647829;37839361",
        "class_list": "",
        "function": "Defining the phenotype of PGAP3-congenital disorder of glycosylation; a review of 65 cases. Review article, [RefSeq, PubMed]; Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene. Publication Status: Online-Only, [RefSeq, PubMed]; High PGAP3 expression is associated with lymph node metastasis and low CD8[+]T cell in patients with HER2[+] breast cancer., [RefSeq, PubMed]; Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Involved in the lipid remodeling steps of GPI-anchor maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MGC9753, consisting of eight exons, clustered with PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes within the 120-kb region of chromosome 17q12; PPP1R1B, STARD3, MGC9753, ERBB2 and GRB7 genes are co-amplified in several cases of gastric cancer, [RefSeq, PubMed]; Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus., [RefSeq, PubMed]; The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis., [RefSeq, PubMed]; This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DGK7;Q86Z03;Q8NBJ8",
        "ec_number_list": [
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0006505 GPI anchor metabolic process;GO:0006506 GPI anchor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q96FM1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96GW7-1",
        "uniprot_id": [
            {
                "id": "PGCB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96GW7",
                "type": "external"
            }
        ],
        "mass": 99118.0,
        "length": 911,
        "protein_name": "Brevican core protein",
        "gene_name": "BCAN",
        "organism": "Human",
        "refseq_name": "brevican core protein isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_068767",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068767",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "BCAN; BEHAB; CSPG7; PRO6018",
        "gene_names_refseq": "BCAN; BEHAB; CSPG7",
        "protein_names_uniprotkb": "Brevican core protein; BEHAB; Brain-enriched hyaluronan-binding protein; Chondroitin sulfate proteoglycan 7",
        "protein_names_refseq": "brain-enriched hyaluronan-binding protein; brevican core protein isoform 1 precursor; brevican core protein; chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); high grade glioma (Disease Ontology:DOID:3070); middle cerebral artery infarction (Disease Ontology:DOID:3525)",
        "pathway": " (hsa:63827);  (R-HSA-1474228);  (R-HSA-1971475);  (R-HSA-2022870);  (R-HSA-2022923);  (R-HSA-2024101);  (R-HSA-3000178);  (R-HSA-3560783);  (R-HSA-3560801);  (R-HSA-3595172);  (R-HSA-3595174);  (R-HSA-3595177);  (R-HSA-4420332)",
        "pathway_count": 13,
        "publication_count": 201,
        "publication_id_list": "10.1038/emboj.2013.79;10022829;10187838;10229672;10339581;10339611;10386589;10473568;10506123;10673326;10706100;10781596;10781601;10809722;10842173;10963998;10986281;11038354;11054543;11056388;11084047;11099377;11139592;11237011;11259413;11375993;11414686;11470797;11514575;11551958;11568288;11788602;11872628;11877387;12080076;12145278;12163485;12225811;12512856;12522689;12556911;12727852;12761225;12843408;12874280;12888274;12907687;12975309;1376317;14715956;14973287;14993226;15075323;15211654;15215498;15234972;15294915;15296743;1544908;15461586;15489334;15591058;15647514;15958533;16133547;16293224;16493581;1649600;16505484;16631740;16710414;16825321;1698775;1707285;17194707;17227754;17332331;17354228;17588949;17608959;18316376;18434311;18513679;18658137;18698629;19010778;1907800;19188366;19224584;1928092;1946389;19473117;19571574;19576282;19657146;19661164;19714641;19838169;19889881;20004762;20142769;20533528;2059554;20691685;20830804;21030783;21129727;21129728;2122463;21297635;21441952;21642437;21670566;21763480;21784848;21789315;21864727;21997179;22134916;22159414;22810237;22930747;23035980;23481700;23584533;2364322;23656592;23664117;23664118;23704329;23845380;2412224;2420006;2430969;24425863;24443026;25326458;25521717;27599773;28657654;29308320;29514872;29557506;2971395;29777959;30459171;30568303;31154438;3134052;31844290;32157095;32387766;32559242;32814053;32845505;32938616;3468507;35051231;36228153;37074911;37453717;38254675;5822067;6193777;6439184;7075587;738706;7499434;7527058;7542669;7547873;7559467;7592978;7628016;7685013;7693733;7852349;8002934;8213840;8226919;8440685;8626565;8798654;8943283;9065415;9115292;9148753;9223416;9252349;9294172;9341124;9346959;9461298;9506957;9521684;9685393;9823490;9852107;9883891;9892646;9949188",
        "class_list": "glycogene",
        "function": "May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans., [UniProtKB]; Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort. Publication Status: Online-Only, [RefSeq, PubMed]; The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility. Review article, [RefSeq, PubMed]; This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1243,
        "reported_interactions": 1,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 3,
        "glyco_site_count": 12,
        "binding_glycan_count": 1,
        "secondary_ac_list": "D3DVC2;Q5SZ10;Q5T3I5;Q8TBB9;Q9HBK1;Q9HBK4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0045202 synapse",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0060074 synapse maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 22.2,
        "record_id": "Q96GW7-1",
        "record_type": "protein",
        "filter_code": "0000000.1001111.100000.000000000001000000.1100000000001.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92521-1",
        "uniprot_id": [
            {
                "id": "PIGB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92521",
                "type": "external"
            }
        ],
        "mass": 65056.0,
        "length": 554,
        "protein_name": "GPI alpha-1,2-mannosyltransferase 3",
        "gene_name": "PIGB",
        "organism": "Human",
        "refseq_name": "GPI alpha-1,2-mannosyltransferase 3",
        "refseq_ac": [
            {
                "id": "NP_004846",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004846",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIGB",
        "gene_names_refseq": "DEE80; EIEE80; GPI-MT-III; PIG-B; PIGB",
        "protein_names_uniprotkb": "GPI alpha-1,2-mannosyltransferase 3; 2.4.1.-; GPI mannosyltransferase III; GPI-MT-III; PIG-B; Phosphatidylinositol-glycan biosynthesis class B protein",
        "protein_names_refseq": "GPI alpha-1,2-mannosyltransferase 3; GPI mannosyltransferase 3; GPI mannosyltransferase III; dol-P-Man dependent GPI mannosyltransferase III; dol-P-Man dependent GPI mannosyltransferase; phosphatidylinositol glycan, class B; phosphatidylinositol-glycan biosynthesis class B protein",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 80 (Disease Ontology:DOID:0112216); sleeping sickness (Disease Ontology:DOID:10112)",
        "pathway": " (hsa:9488);  (R-HSA-162710)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10.1101/2023.09.13.557529;10069808;10089216;10944123;11226175;11237011;14517336;14742432;15623507;15632136;15635094;15720390;16162815;17311586;17343268;18198489;24714562;25645385;26154972;26375851;26992070;27846572;28218747;28228285;28832583;28834231;28904123;29242379;29437277;29764287;29786170;30315122;30429286;30833945;31154438;31256876;31844290;31848261;32157095;32357974;32488085;32938616;32983136;33091337;33298915;33537174;33912179;33968037;34171305;34400385;35051231;35580925;36284347;7907094;8861954;8900170;9463366",
        "class_list": "glycogene;glycosyltransferase",
        "function": "A novel intronic variant in PIGB in Acrofrontofacionasal dysostosis type 1 patients expands the spectrum of phenotypes associated with GPI biosynthesis defects., [RefSeq, PubMed]; Alpha-1,2-mannosyltransferase that catalyzes the transfer of the third mannose, via an alpha-1,2 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) and participates in the nineth step of the glycosylphosphatidylinositol-anchor biosynthesis (Probable). May also add the third mannose to a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) intermediate generating a 2-acyl-6-(alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H4) (Probable)., [UniProtKB, PubMed, PubMed]; Downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells., [RefSeq, PubMed]; Function of a membrane-embedded domain evolutionarily multiplied in the GPI lipid anchor pathway proteins PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z has been described., [RefSeq, PubMed]; Mutations in PIGB Cause an Inherited GPI Biosynthesis Defect with an Axonal Neuropathy and Metabolic Abnormality., [RefSeq, PubMed]; This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 673,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53FF9;Q8WVN7",
        "ec_number_list": [
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0004376 GPI mannosyltransferase activity;GO:0120564 dol-P-Man:Man(2)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006506 GPI anchor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q92521-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010000.101.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02809-1",
        "uniprot_id": [
            {
                "id": "PLOD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02809",
                "type": "external"
            }
        ],
        "mass": 83550.0,
        "length": 727,
        "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",
        "gene_name": "PLOD1",
        "organism": "Human",
        "refseq_name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_000293",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000293",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLOD1; LLH; PLOD",
        "gene_names_refseq": "EDS6; EDSKCL1; LH1; LH; LLH; PLOD1; PLOD",
        "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; 1.14.11.4; LH1; Lysyl hydroxylase 1",
        "protein_names_refseq": "lysine hydroxylase; lysyl hydroxlase 1; procollagen lysyl hydroxylase 1; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "Ehlers-Danlos syndrome kyphoscoliotic type 1 (Disease Ontology:DOID:0080734); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); hypothyroidism (Disease Ontology:DOID:1459)",
        "pathway": " (hsa:5351);  (R-HSA-1650814)",
        "pathway_count": 2,
        "publication_count": 149,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10329027;10479448;10686424;10934207;11001813;11237011;12473679;12475640;12646579;1323838;1345174;14500733;15044469;15666309;1577494;15854030;15979919;16591531;16959974;18487197;18507432;19075007;19615748;19693541;20068231;20470363;21081667;21209280;21654843;21878990;21967573;222849;22299025;24190977;25418920;2543975;25502872;25576301;25645385;25813380;26375851;26811146;26992070;27090790;27846572;27920218;28218747;28228285;28467828;28649982;28832583;28834231;28904123;29242379;29314611;29331515;29393594;29557506;29632046;29632711;29741879;29786170;30001391;30315122;30397120;30410026;30429286;30524438;30573663;30626607;30833945;3110540;31217245;31530632;31611695;3173483;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32938616;32983136;33043033;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33912179;33936100;33968037;34019948;34089345;34171305;34185709;34357683;34400365;34433824;34455762;34509645;34561969;34725712;34845571;34932366;35051231;35149972;35154160;35251023;35254053;35289036;35318648;35494241;35580925;36010968;36215666;36284347;36695693;37074911;37217939;37938771;38665916;3905801;3931636;3938630;40596516;416188;6089551;6307276;6809411;710450;7713497;8163671;8533783;8621606;9054364;9152832;9545296;9560306;9582318;9617436;9893157",
        "class_list": "glycogene",
        "function": "Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]; MiR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages., [RefSeq, PubMed]; New mechanistic insights to PLOD1-mediated human vascular disease., [RefSeq, PubMed]; P3H4 and PLOD1 expression associates with poor prognosis in bladder cancer., [RefSeq, PubMed]; PLOD1 acts as a tumor promoter in glioma via activation of the HSF1 signaling pathway., [RefSeq, PubMed]; PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer., [RefSeq, PubMed]; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:10686424, PubMed:15854030, PubMed:8621606). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 4,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 1050,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 56,
        "disease_count": 3,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DR87;Q96AV9;Q9H132",
        "ec_number_list": [
            {
                "id": "1.14.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4",
                "type": "external"
            },
            {
                "id": "2.4.1.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50",
                "type": "external"
            },
            {
                "id": "2.4.1.66",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0008544 epidermis development;GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 21.3,
        "record_id": "Q02809-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15111-1",
        "uniprot_id": [
            {
                "id": "PLCL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15111",
                "type": "external"
            }
        ],
        "mass": 122728.0,
        "length": 1095,
        "protein_name": "Inactive phospholipase C-like protein 1",
        "gene_name": "PLCL1",
        "organism": "Human",
        "refseq_name": "inactive phospholipase C-like protein 1",
        "refseq_ac": [
            {
                "id": "NP_006217",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006217",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCL1",
        "gene_names_refseq": "PLCE; PLCL1; PLCL; PLDL1; PPP1R127; PRIP",
        "protein_names_uniprotkb": "Inactive phospholipase C-like protein 1; PLC-L1; PRIP; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein",
        "protein_names_refseq": "PLC-L1; inactive phospholipase C-like protein 1; phospholipase C, epsilon; phospholipase C-deleted in lung carcinoma; phospholipase C-like 1; phospholipase C-related but catalytically inactive protein; protein phosphatase 1, regulatory subunit 127",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5334)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;11278544;11867528;16404143;16754670;16854455;16952428;17254016;18776929;19651622;23186163;24715725;26758079;27600516;28411811;29557506;29786170;30379171;31530632;32157095;32265295;32387766;34115876;35051231;35254053;35820936;36010968;37801481;39456056;7633416",
        "class_list": "",
        "function": "DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of novel pleiotropic gene for bone mineral density and lean mass using the cFDR method., [RefSeq, PubMed]; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C., [UniProtKB, PubMed]; PLCL1 is a novel gene associated with variation in hip bone size, which has a role in the pathogenesis of hip fractures GeneRIF: Genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[PLoS ONE. 2009;4(2). doi: 10.1371/annotation/951f0d10-0b78-4d6b-94c9-8ae6cc4178dd. Chinnapen-Horsley, Usha [corrected to Chinappen-Horsley, Usha]; Cervino, Alesandra [corrected to Cervino, Alessandra]] Publication Status: Online-Only, [RefSeq, PubMed]; PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma., [RefSeq, PubMed]; PRIP-1 plays an important role in type A receptor signaling for gamma-aminobutyric acid in the brain, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MJ90;Q53SD3;Q7Z3S3",
        "ec_number_list": [
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004629 phospholipase C activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q15111-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15041-1",
        "uniprot_id": [
            {
                "id": "SEM3E_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15041",
                "type": "external"
            }
        ],
        "mass": 89228.0,
        "length": 775,
        "protein_name": "Semaphorin-3E",
        "gene_name": "SEMA3E",
        "organism": "Human",
        "refseq_name": "semaphorin-3E isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001171600",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171600",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEMA3E; KIAA0331; SEMAH",
        "gene_names_refseq": "M-SEMAH; M-SemaK; SEMA3E; SEMAH; coll-5",
        "protein_names_uniprotkb": "Semaphorin-3E",
        "protein_names_refseq": "sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; semaphorin-3E isoform 2",
        "tax_id": 9606,
        "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); transient cerebral ischemia (Disease Ontology:DOID:224)",
        "pathway": " (hsa:9723);  (R-HSA-416700)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10.1101/2023.09.13.557529;10520995;10648410;11114375;11237011;12882840;15218527;15235037;15550623;16715077;17318185;29393594;29557506;29786170;30447428;30736100;31170375;32157095;33091337;33968037;34171305;35917012;36010968;37175783;8955171",
        "class_list": "",
        "function": "PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer., [RefSeq, PubMed]; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)., [UniProtKB]; Recently discovered regulatory role of semaphorin3E in modulating immune cells and structural cells function in the airways. These findings support the concept of semaphorin3E/plexinD1 axis as a therapeutic target in allergic asthma. Review article, [RefSeq, PubMed]; SEMA3E is a novel regulator in intestinal inflammation that regulates intestinal epithelium apoptosis., [RefSeq, PubMed]; Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]., [RefSeq]; The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance. Publication Status: Online-Only, [RefSeq, PubMed]; The SEMA3E is reduced in colitis and modulates colonic inflammation by regulating the interaction between CD11c(+) and CD4(+) CD25(-) T-cells via an NF-kappaB-dependent mechanism., [RefSeq, PubMed]; The translocation envolving chromosomes 2 and 7 with SEMA3E within 200 kb of the translocation breakpoint on 7q21.11 in a patient with CHARGE syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E1P1;Q75M94;Q75M97",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0050808 synapse organization;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071526 semaphorin-plexin signaling pathway;GO:0043524 negative regulation of neuron apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "O15041-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N328-1",
        "uniprot_id": [
            {
                "id": "PGBD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N328",
                "type": "external"
            }
        ],
        "mass": 67595.0,
        "length": 593,
        "protein_name": "PiggyBac transposable element-derived protein 3",
        "gene_name": "PGBD3",
        "organism": "Human",
        "refseq_name": "piggyBac transposable element-derived protein 3",
        "refseq_ac": [
            {
                "id": "NP_736609",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_736609",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGBD3",
        "gene_names_refseq": "PGBD3",
        "protein_names_uniprotkb": "PiggyBac transposable element-derived protein 3",
        "protein_names_refseq": "piggyBac transposable element-derived protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:267004)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "16959974;18369450;22483866;23186163;26218421;26992070;28855257;30429286;31844290;32157095;32488085;33091337;34171305;34932366;35051231;35318648;35580925",
        "class_list": "",
        "function": "A domesticated PiggyBac-like transposon PGBD3, residing within intron 5 of the CSB gene, functions as an alternative 3' terminal exon Publication Status: Online-Only, [RefSeq, PubMed]; Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF., [UniProtKB, PubMed]; CSB-PGBD3 fusion protein is important in both health and disease, and could play a role in Cockayne syndrome., [RefSeq, PubMed]; This gene is a member of a small family of genes derived from piggyBac transposable elements. The encoded protein contains a zinc-ribbon domain characteristic of transposon-derived proteins and may function as a regulator of transcription. Alternative splicing occurs between a splice site from exon 5 of the adjacent upstream gene 'excision repair cross-complementation group 6' (ERCC6, GeneID: 2074) and the 3' splice site upstream of the open reading frame (ORF) of this gene, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. Pseudogenes for this gene are defined on chromosomes 4, 5 and 12. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQC4;Q5W0M0;Q6PIH0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8N328-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H2J4-1",
        "uniprot_id": [
            {
                "id": "PDCL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H2J4",
                "type": "external"
            }
        ],
        "mass": 27614.0,
        "length": 239,
        "protein_name": "Phosducin-like protein 3",
        "gene_name": "PDCL3",
        "organism": "Human",
        "refseq_name": "phosducin-like protein 3",
        "refseq_ac": [
            {
                "id": "NP_076970",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076970",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDCL3; PhLP2A; VIAF1",
        "gene_names_refseq": "HTPHLP; PDCL3; PHLP2A; PHLP3; VIAF1; VIAF",
        "protein_names_uniprotkb": "Phosducin-like protein 3; HTPHLP; PhPL3; VIAF-1; Viral IAP-associated factor 1",
        "protein_names_refseq": "IAP-associated factor VIAF1; VIAF-1; phPL3; phosducin-like protein 3; viral IAP-associated factor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79031)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "10203015;11237011;15371430;17429077;18669648;19012568;19651622;20068231;21406692;23186163;23792958;24714562;24715725;25418920;25502872;25576301;25645385;26059764;26154972;26811146;26830138;26992070;27496612;27600516;27846572;27893789;27920218;28228285;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632046;29632711;29786170;29789417;30315122;30379171;30429286;30484775;31154438;31530632;31844290;31848261;32157095;32161166;32357974;32488085;32502341;32621347;32897882;32938616;33537174;33691108;33717175;33912179;33968037;33981976;34087483;34932366;35051231;35561310;35580925;36010968;36241641;36284347;37938771;38665916;39107869;40914422",
        "class_list": "",
        "function": "Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function., [RefSeq, PubMed]; Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. GeneRIF: Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2., [RefSeq, PubMed]; Family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3.  In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7)., [RefSeq, PubMed]; Fetal megacystis-microcolon: Genetic mutational spectrum and identification of PDCL3 as a novel candidate gene., [RefSeq, PubMed]; PDCL3 as a prognostic factor and associated with the VEGF signaling pathway in glioma., [RefSeq, PubMed]; Results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins., [RefSeq, PubMed]; This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA00;Q53S68",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043184 vascular endothelial growth factor receptor 2 binding;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0006915 apoptotic process;GO:0045766 positive regulation of angiogenesis;GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.7,
        "record_id": "Q9H2J4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGE1-1",
        "uniprot_id": [
            {
                "id": "OR6C4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGE1",
                "type": "external"
            }
        ],
        "mass": 35010.0,
        "length": 309,
        "protein_name": "Olfactory receptor 6C4",
        "gene_name": "OR6C4",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6C4",
        "refseq_ac": [
            {
                "id": "NP_001005494",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005494",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6C4",
        "gene_names_refseq": "OR12-10; OR6C4",
        "protein_names_uniprotkb": "Olfactory receptor 6C4; Olfactory receptor OR12-10",
        "protein_names_refseq": "olfactory receptor 6C4; olfactory receptor OR12-10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:341418);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 13,
        "publication_id_list": "14983052;24800820;27515280;28832583;29242379;29557506;31974307;32066986;33592498;33968037;35051231;35289036;36010968",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MZG7;B2RNN2;Q6IFK1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q8NGE1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGF8-1",
        "uniprot_id": [
            {
                "id": "OR4B1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGF8",
                "type": "external"
            }
        ],
        "mass": 34456.0,
        "length": 309,
        "protein_name": "Olfactory receptor 4B1",
        "gene_name": "OR4B1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 4B1",
        "refseq_ac": [
            {
                "id": "NP_001005470",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005470",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR4B1",
        "gene_names_refseq": "OR11-106; OR4B1; OST208",
        "protein_names_uniprotkb": "Olfactory receptor 4B1; OST208; Olfactory receptor OR11-106",
        "protein_names_refseq": "olfactory receptor 4B1; olfactory receptor OR11-106",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:119765);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "14983052;24800820;27515280;29557506;31974307;32066986;33392160;34087483;34171305",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IF75;Q96R64",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NGF8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG0-1",
        "uniprot_id": [
            {
                "id": "OR8J3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG0",
                "type": "external"
            }
        ],
        "mass": 35481.0,
        "length": 315,
        "protein_name": "Olfactory receptor 8J3",
        "gene_name": "OR8J3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8J3",
        "refseq_ac": [
            {
                "id": "NP_001004064",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004064",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8J3",
        "gene_names_refseq": "OR11-173; OR8J3",
        "protein_names_uniprotkb": "Olfactory receptor 8J3; Olfactory receptor OR11-173",
        "protein_names_refseq": "olfactory receptor 8J3; olfactory receptor OR11-173",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81168);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFB6;Q96RC2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NGG0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGG1-1",
        "uniprot_id": [
            {
                "id": "OR8J2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGG1",
                "type": "external"
            }
        ],
        "mass": 35160.0,
        "length": 315,
        "protein_name": "Olfactory receptor 8J2",
        "gene_name": "OR8J2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR8J2; OR8J2P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Olfactory receptor 8J2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-9752946)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "12730696;24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8NGG1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGN1-1",
        "uniprot_id": [
            {
                "id": "OR6T1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGN1",
                "type": "external"
            }
        ],
        "mass": 36348.0,
        "length": 323,
        "protein_name": "Olfactory receptor 6T1",
        "gene_name": "OR6T1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6T1",
        "refseq_ac": [
            {
                "id": "NP_001005187",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005187",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6T1",
        "gene_names_refseq": "OR11-277; OR6T1",
        "protein_names_uniprotkb": "Olfactory receptor 6T1; Olfactory receptor OR11-277",
        "protein_names_refseq": "olfactory receptor 6T1; olfactory receptor OR11-277",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219874);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "14983052;24800820;27515280;31974307;32066986;32387766;32488085;33912179;35051231;35580925;38253038",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFE7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8NGN1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NGY5-1",
        "uniprot_id": [
            {
                "id": "OR6N1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NGY5",
                "type": "external"
            }
        ],
        "mass": 34869.0,
        "length": 312,
        "protein_name": "Olfactory receptor 6N1",
        "gene_name": "OR6N1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6N1",
        "refseq_ac": [
            {
                "id": "NP_001005185",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005185",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6N1",
        "gene_names_refseq": "OR1-22; OR6N1",
        "protein_names_uniprotkb": "Olfactory receptor 6N1",
        "protein_names_refseq": "olfactory receptor 6N1; olfactory receptor OR1-22",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128372);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "24800820;25892735;25977809;27515280;31974307;32066986;32161166;34087483;36241641",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUT4;Q5VUU8;Q96R35",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NGY5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH03-1",
        "uniprot_id": [
            {
                "id": "OR2T3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH03",
                "type": "external"
            }
        ],
        "mass": 35598.0,
        "length": 318,
        "protein_name": "Olfactory receptor 2T3",
        "gene_name": "OR2T3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 2T3",
        "refseq_ac": [
            {
                "id": "NP_001005495",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005495",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR2T3",
        "gene_names_refseq": "OR2T3",
        "protein_names_uniprotkb": "Olfactory receptor 2T3",
        "protein_names_refseq": "olfactory receptor 2T3; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:343173);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "24800820;25576301;27515280;31974307;32066986;33141586;35051231",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNJ1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8NH03-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH10-1",
        "uniprot_id": [
            {
                "id": "OR8U1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH10",
                "type": "external"
            }
        ],
        "mass": 35088.0,
        "length": 309,
        "protein_name": "Olfactory receptor 8U1",
        "gene_name": "OR8U1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8U1",
        "refseq_ac": [
            {
                "id": "NP_001005204",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005204",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8U1",
        "gene_names_refseq": "OR8U1",
        "protein_names_uniprotkb": "Olfactory receptor 8U1",
        "protein_names_refseq": "olfactory receptor 8U1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219417);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 4,
        "publication_id_list": "24800820;27515280;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8NH10-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NH51-1",
        "uniprot_id": [
            {
                "id": "OR8K3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NH51",
                "type": "external"
            }
        ],
        "mass": 35463.0,
        "length": 312,
        "protein_name": "Olfactory receptor 8K3",
        "gene_name": "OR8K3",
        "organism": "Human",
        "refseq_name": "olfactory receptor 8K3",
        "refseq_ac": [
            {
                "id": "NP_001005202",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005202",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR8K3",
        "gene_names_refseq": "OR11-181; OR8K3",
        "protein_names_uniprotkb": "Olfactory receptor 8K3; Olfactory receptor OR11-181",
        "protein_names_refseq": "olfactory receptor 8K3; olfactory receptor OR11-181; olfactory receptor, family 8, subfamily K, member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219473);  (R-HSA-381753);  (R-HSA-9752946)",
        "pathway_count": 3,
        "publication_count": 24,
        "publication_id_list": "10460249;14983052;15598656;17601748;17873857;17973576;19474308;19581598;24316890;24800820;25784876;25977809;26373539;27515280;27916747;27916748;28656349;28860189;28904123;29235485;31040214;31844290;31974307;32066986",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IFC4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q8NH51-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHA6-1",
        "uniprot_id": [
            {
                "id": "OR2W6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHA6",
                "type": "external"
            }
        ],
        "mass": 35283.0,
        "length": 318,
        "protein_name": "Putative olfactory receptor 2W6",
        "gene_name": "OR2W6P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "OR2W6P; OR2W7P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative olfactory receptor 2W6; Olfactory receptor OR6-3; Putative olfactory receptor 2W7",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "14983052",
        "class_list": "",
        "function": "Odorant receptor., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q8NHA6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QZ0-1",
        "uniprot_id": [
            {
                "id": "PANX3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QZ0",
                "type": "external"
            }
        ],
        "mass": 44683.0,
        "length": 392,
        "protein_name": "Pannexin-3",
        "gene_name": "PANX3",
        "organism": "Human",
        "refseq_name": "pannexin-3",
        "refseq_ac": [
            {
                "id": "NP_443191",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443191",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PANX3",
        "gene_names_refseq": "PANX3; PX3",
        "protein_names_uniprotkb": "Pannexin-3",
        "protein_names_refseq": "gap junction protein pannexin 3; pannexin-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116337)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "15028292;17925379;20086016;20404334;24715725;27679980;29222846;29241211;29357945;31154438;35580925;36448979",
        "class_list": "",
        "function": "All three pannexins Panx1, Panx2, and Panx3 mRNAs were expressed in all of the analyzed undifferentiated stem cell lines. Publication Status: Online-Only, [RefSeq, PubMed]; Although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules, [RefSeq, PubMed]; Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3., [RefSeq, PubMed]; Noncoding rare variants in PANX3 are associated with chronic back pain., [RefSeq, PubMed]; Panx3 functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels, [RefSeq, PubMed]; Panx3 has a defensive role in dental pulp inflammation., [RefSeq, PubMed]; Panx3 was upregulated during osteogenic differentiation in a time-dependent manner. Panx3 overexpression promoted osteogenic differentiation of human dental pulp-derived mesenchymal stromal cells, whereas depletion of Panx3 resulted in a decline of differentiation., [RefSeq, PubMed]; Regulator of osteoblast differentiation by functioning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]., [RefSeq]; These studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005198 structural molecule activity;GO:0055077 gap junction hemi-channel activity;GO:0022829 wide pore channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005921 gap junction",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0006812 monoatomic cation transport;GO:0001649 osteoblast differentiation;GO:0032732 positive regulation of interleukin-1 production",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q96QZ0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RD1-1",
        "uniprot_id": [
            {
                "id": "OR6C1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RD1",
                "type": "external"
            }
        ],
        "mass": 35660.0,
        "length": 312,
        "protein_name": "Olfactory receptor 6C1",
        "gene_name": "OR6C1",
        "organism": "Human",
        "refseq_name": "olfactory receptor 6C1",
        "refseq_ac": [
            {
                "id": "NP_001005182",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005182",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OR6C1",
        "gene_names_refseq": "OR6C1; OST267",
        "protein_names_uniprotkb": "Olfactory receptor 6C1; OST267",
        "protein_names_refseq": "olfactory receptor 6C1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390321);  (R-HSA-9752946)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "20677014;24800820;27515280;31974307;32066986;35051231",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNM0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96RD1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RD6-3",
        "uniprot_id": [
            {
                "id": "PANX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RD6",
                "type": "external"
            }
        ],
        "mass": 74447.0,
        "length": 677,
        "protein_name": "Pannexin-2",
        "gene_name": "PANX2",
        "organism": "Human",
        "refseq_name": "pannexin-2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001153772",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153772",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PANX2",
        "gene_names_refseq": "PANX2; PX2; hPANX2",
        "protein_names_uniprotkb": "Pannexin-2",
        "protein_names_refseq": "pannexin-2 isoform 2",
        "tax_id": 9606,
        "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)",
        "pathway": " (hsa:56666);  (R-HSA-112303)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "10462698;12881038;14597722;15028292;16959974;16989724;20930146;22445341;24454290;24715725;28649982;29557506;29932112;30379171;32161166;32488085;32938616;33003647;33298915;33836029;33913372;34087483;34171305;35051231;36869038;36973289;39389335",
        "class_list": "",
        "function": "According to brain cancer gene expression database REMBRANDT, PANX2 expression levels can predict post diagnosis survival for patients with glial tumors. Review article, [RefSeq, PubMed]; Cryo-EM structure of human heptameric pannexin 2 channel. Publication Status: Online-Only, [RefSeq, PubMed]; Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; PANX2 and brain lower grade glioma genesis: A bioinformatic analysis., [RefSeq, PubMed]; PANX2 promotes malignant transformation of colorectal cancer and 5-Fu resistance through PI3K-AKT signaling pathway., [RefSeq, PubMed]; Structural and functional analysis of human pannexin 2 channel. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z684;Q96RD5;Q9UGX8",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity;GO:0005243 gap junction channel activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport;GO:0032732 positive regulation of interleukin-1 production",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q96RD6-3",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BSG0-1",
        "uniprot_id": [
            {
                "id": "PADC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BSG0",
                "type": "external"
            }
        ],
        "mass": 21042.0,
        "length": 188,
        "protein_name": "Protease-associated domain-containing protein 1",
        "gene_name": "PRADC1",
        "organism": "Human",
        "refseq_name": "protease-associated domain-containing protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_115695",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115695",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRADC1; C2orf7; PAP21; PRO1760",
        "gene_names_refseq": "C2orf7; PAP21; PRADC1",
        "protein_names_uniprotkb": "Protease-associated domain-containing protein 1; Protease-associated domain-containing protein of 21 kDa; hPAP21",
        "protein_names_refseq": "protease-associated domain-containing glycoprotein 21 kDa; protease-associated domain-containing protein 1 precursor; protease-associated domain-containing protein 1; protease-associated domain-containing protein of 21 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84279)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "12975309;15498570;28904123;29393594;31844290;31848261;32265295;33912179;34561969",
        "class_list": "",
        "function": "Plays a role in the modulation of physical activity and adiposity., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2Z1P2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9BSG0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9GZY1-1",
        "uniprot_id": [
            {
                "id": "PBOV1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9GZY1",
                "type": "external"
            }
        ],
        "mass": 15722.0,
        "length": 135,
        "protein_name": "Prostate and breast cancer overexpressed gene 1 protein",
        "gene_name": "PBOV1",
        "organism": "Human",
        "refseq_name": "prostate and breast cancer overexpressed gene 1 protein",
        "refseq_ac": [
            {
                "id": "NP_067648",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067648",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PBOV1; UROC28",
        "gene_names_refseq": "PBOV1; UC28; UROC28; dJ171N11.2",
        "protein_names_uniprotkb": "Prostate and breast cancer overexpressed gene 1 protein; Protein UROC28; UC28",
        "protein_names_refseq": "prostate and breast cancer overexpressed gene 1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:59351)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11156405;12553037;17656261;19714462;23418531;26549570;29557506;30231487;34278444;35494241",
        "class_list": "",
        "function": "Approximately half of the prostate tumors displayed increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci, which may account for their abnormal gene expression patterns in neoplastic prostate tissue., [RefSeq, PubMed]; Data indicate that analysis of public microarray data suggests that PBOV1 activation in tumors could be dependent on the Hedgehog signaling pathway., [RefSeq, PubMed]; FBXL19AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR431 and upregulate PBOV1., [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of PBOV1 in THP-1 cells resulted in cell cycle G1 arrest, differentiation into macrophages, a marked increase in IL-10 and CXCL10 mRNA levels, and upregulation of the costimulatory molecules. Publication Status: Online-Only, [RefSeq, PubMed]; Study shows that patients with high PBOV1 expression had longer overall survival; patients with low PBOV1 expression had shorter survival suggesting that PBOV1 may play an important role in suppressing ovarian cancer proliferation and carcinogenesis., [RefSeq, PubMed]; This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011]., [RefSeq]; UROC28 mRNA expression was greater in breast cancers than in noncancerous tissues (p < 0.0001), as was ERBB2 mRNA., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9GZY1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H361-1",
        "uniprot_id": [
            {
                "id": "PABP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H361",
                "type": "external"
            }
        ],
        "mass": 70031.0,
        "length": 631,
        "protein_name": "Polyadenylate-binding protein 3",
        "gene_name": "PABPC3",
        "organism": "Human",
        "refseq_name": "polyadenylate-binding protein 3",
        "refseq_ac": [
            {
                "id": "NP_112241",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112241",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PABPC3; PABP3; PABPL3",
        "gene_names_refseq": "PABP3; PABPC3; PABPL3; tPABP",
        "protein_names_uniprotkb": "Polyadenylate-binding protein 3; PABP-3; Poly(A)-binding protein 3; Testis-specific poly(A)-binding protein",
        "protein_names_refseq": "PABP-3; poly(A)-binding protein-like 3; polyadenylate-binding protein 3; testis PABP; testis-specific poly(A)-binding protein (PABP); testis-specific poly(A)-binding protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5042)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "10.1101/2023.09.13.557529;11230166;11328870;24714562;24715725;25505266;26024233;26154972;26843391;29493099;29557506;30315122;30418433;30620550;30779550;30833945;31154438;31222486;31530632;31844290;31848261;31937595;31998317;32161166;32502341;33123756;33298915;33912179;33981976;34019948;34105348;35051231;35254053",
        "class_list": "",
        "function": "Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1., [UniProtKB]; Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]., [RefSeq]; Molecular cloning and expression in testis, [RefSeq, PubMed]; PABPC3 decreased expression in in infertile men with non-obstructive azoospermia, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 66,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NHV0;Q9H086",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0010494 cytoplasmic stress granule",
        "go_biological_process": "GO:0016071 mRNA metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q9H361-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHG2-1",
        "uniprot_id": [
            {
                "id": "PCS1N_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHG2",
                "type": "external"
            }
        ],
        "mass": 27372.0,
        "length": 260,
        "protein_name": "ProSAAS",
        "gene_name": "PCSK1N",
        "organism": "Human",
        "refseq_name": "proSAAS preproprotein",
        "refseq_ac": [
            {
                "id": "NP_037403",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037403",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PCSK1N",
        "gene_names_refseq": "BigLEN; PCSK1N; PEN; PROSAAS; SAAS; SCG8; SgVIII",
        "protein_names_uniprotkb": "ProSAAS; N-proSAAS; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; SAAS CT(1-49); SAAS CT(25-40); pro-SAAS",
        "protein_names_refseq": "granin-like neuroendocrine peptide; pro-SAAS; proSAAS preproprotein; proprotein convertase 1 inhibitor",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:27344)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "10.1038/emboj.2013.79;10632593;11435430;11719503;12914799;14746899;19838169;22171320;22695173;23234360;23584533;27457957;29393594;29557506;29789417;30429286;31154438;31844290;31848261;32157095;34087483;34171305;35051231;36010968;36284347;37217939;37938771",
        "class_list": "",
        "function": "Although both proSAAS and 7B2 potently inhibit PC enzymes via a C-terminal peptide, their intracellular interactions with PCs appear to differ significantly, with each binding protein exhibiting unique properties, [RefSeq, PubMed]; Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding., [UniProtKB, UniProtKB]; Endogenous ligand for GPR83. Neuropeptide involved in the regulation of feeding., [UniProtKB, UniProtKB]; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity)., [UniProtKB, UniProtKB]; Neuronal proSAAS plays an important role in proteostatic processes., [RefSeq, PubMed]; Results show significant differences in distribution of single nucleotide polymorphism in this gene amongst whites and hispanics, [RefSeq, PubMed]; The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VC04",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0004866 endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q9UHG2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5Y4-1",
        "uniprot_id": [
            {
                "id": "PD2R2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5Y4",
                "type": "external"
            }
        ],
        "mass": 43268.0,
        "length": 395,
        "protein_name": "Prostaglandin D2 receptor 2",
        "gene_name": "PTGDR2",
        "organism": "Human",
        "refseq_name": "prostaglandin D2 receptor 2",
        "refseq_ac": [
            {
                "id": "NP_004769",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004769",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTGDR2; CRTH2; DL1R; GPR44",
        "gene_names_refseq": "CD294; CRTH2; DL1R; DP2; GPR44; PTGDR2",
        "protein_names_uniprotkb": "Prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G protein-coupled receptor 44",
        "protein_names_refseq": "chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; putative G-protein coupled receptor 44",
        "tax_id": 9606,
        "disease": "aspergillosis (Disease Ontology:DOID:13564); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); allergic asthma (Disease Ontology:DOID:9415); pulmonary eosinophilia (Disease Ontology:DOID:9498)",
        "pathway": " (hsa:11251);  (R-HSA-391908);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 50,
        "publication_id_list": "10036181;10634944;11007482;11168006;11208866;11535533;11740958;11801628;12120503;12222762;12466225;12519077;15464062;15951850;16634148;16923326;17196174;17207480;18434541;18577758;20035740;2171039;23481700;2534964;2748346;2834384;28832583;29242379;29605689;31154438;32938616;34341104;34750492;35051231;37526190;39052598;39284672;7532011;7642548;7883006;7937899;8015379;8078484;8117308;8163486;8253813;8300593;8406495;9462300;9973380",
        "class_list": "",
        "function": "Arachidonic Acid Directly Activates the Human DP2 Receptor. Publication Status: Online-Only, [RefSeq, PubMed]; CRTH2 is involved in mediating some of the therapeutic and/or unwanted side effects of indomethacin, independently of cyclooxygenases and peroxisome proliferator-activated receptors., [RefSeq, PubMed]; High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model., [RefSeq, PubMed]; Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2., [RefSeq, PubMed]; PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer., [RefSeq, PubMed]; Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94765;Q4QRI6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004958 prostaglandin F receptor activity;GO:0001785 prostaglandin J receptor activity;GO:0004956 prostaglandin D receptor activity;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0019722 calcium-mediated signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9Y5Y4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15212-1",
        "uniprot_id": [
            {
                "id": "PFD6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15212",
                "type": "external"
            }
        ],
        "mass": 14583.0,
        "length": 129,
        "protein_name": "Prefoldin subunit 6",
        "gene_name": "PFDN6",
        "organism": "Human",
        "refseq_name": "prefoldin subunit 6",
        "refseq_ac": [
            {
                "id": "NP_001172110",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001172110",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PFDN6; HKE2; PFD6",
        "gene_names_refseq": "H2-KE2; HKE2; KE-2; PFD6; PFDN6",
        "protein_names_uniprotkb": "Prefoldin subunit 6; Protein Ke2",
        "protein_names_refseq": "HLA class II region expressed gene KE2; KE2 protein; prefoldin subunit 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10471);  (R-HSA-389957)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "11237011;19608861;22645359;24714562;24715725;25114211;25418920;25576301;25645385;25810538;26154972;26375851;26728094;26811146;26992070;27397612;27600516;27846572;27862975;27920218;28063628;28228285;28467828;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30192525;30315122;30429286;31154438;31217245;31530632;31738558;31844290;31848261;32157095;32265295;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33298915;33592498;33717175;33912179;33936100;33968037;34019948;34171305;34433824;34509645;34932366;35051231;35251023;35561310;35580925;36215666;36284347;37938771;9545376;9630229",
        "class_list": "",
        "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB, UniProtKB, PubMed]; PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001540 amyloid-beta binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex",
        "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:1905907 negative regulation of amyloid fibril formation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "O15212-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z3Z3-1",
        "uniprot_id": [
            {
                "id": "PIWL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z3Z3",
                "type": "external"
            }
        ],
        "mass": 101089.0,
        "length": 882,
        "protein_name": "Piwi-like protein 3",
        "gene_name": "PIWIL3",
        "organism": "Human",
        "refseq_name": "piwi-like protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001008496",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008496",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIWIL3",
        "gene_names_refseq": "HIWI3; PIWIL3",
        "protein_names_uniprotkb": "Piwi-like protein 3",
        "protein_names_refseq": "piwi-like 3; piwi-like protein 3 isoform 1; piwi-like protein 3",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:440822)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;12906857;18477386;18616918;20940137;23481700;25576301;25892735;27397612;27858163;28869440;29464001;31154438;32938616",
        "class_list": "",
        "function": "Individuals with HIWI3 non-synonymous rs11703684 variant genotypes exhibited a significantly reduced oligozoospermia risk GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity)., [UniProtKB, UniProtKB]; Our data indicate that PIWIL3 protein expression is elevated in more aggressive primary malignant melanoma(MM )and metastatic disease. As also observed in other malignancies, PIWIL3 seems to play a role in MM progression., [RefSeq, PubMed]; Overexpression of Piwil3 promotes the proliferation, migration and invasion of GC cells partially through JAK2/STAT3 signal pathway., [RefSeq, PubMed]; PIWIL3 proteins were expressed in the cytoplasma of human astrocytic glioma and meningioma., [RefSeq, PubMed]; PIWIL3 was also a target of CEBPA, forming a positive feedback loop in the growth regulation of glioma cells. Significantly, knockdown of OIP5-AS1 combined with over-expression of PIWIL3 and miR-367-3p resulted in tumor regression and extended survival in vivo. Erratum:[Theranostics. 2022 Jan 21;12(4):1732-1733. doi: 10.7150/thno.69398. PMID: 35198067] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004519 endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043186 P granule",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q7Z3Z3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q0ZLH3-1",
        "uniprot_id": [
            {
                "id": "PJVK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q0ZLH3",
                "type": "external"
            }
        ],
        "mass": 39913.0,
        "length": 352,
        "protein_name": "Pejvakin",
        "gene_name": "PJVK",
        "organism": "Human",
        "refseq_name": "pejvakin isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001036167",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036167",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PJVK; DFNB59",
        "gene_names_refseq": "DFNB59; PJVK",
        "protein_names_uniprotkb": "Pejvakin; Autosomal recessive deafness type 59 protein",
        "protein_names_refseq": "autosomal recessive deafness type 59 protein; pejvakin isoform 1",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 59 (Disease Ontology:DOID:0110511)",
        "pathway": " (hsa:494513);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 16,
        "publication_id_list": "10025409;10821263;11163272;11237011;16804542;17301963;17329413;17373699;17718865;22617256;25631766;26544938;28964305;30582396;32387766;35052489",
        "class_list": "",
        "function": "DFNB59, a newly identified gene on chromosome 2q31.1-q31.3 mutated in four families segregating autosomal recessive auditory neuropathy, [RefSeq, PubMed]; Data indicate that nonsense mutations in DFNB59 cause nonsyndromic hearing loss, but that mutations in DFNB59 are not a major cause of nonsyndromic hearing impairment in the Turkish and Dutch population, [RefSeq, PubMed]; Mutations in DFNB59 are associated with autosomal recessive non-syndromic hearing loss in about 6.7% of GJB2-negative families., [RefSeq, PubMed]; Novel Pathogenic Variants in PJVK, the Gene Encoding Pejvakin, in Subjects with Autosomal Recessive Non-Syndromic Hearing Impairment and Auditory Neuropathy Spectrum Disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation., [UniProtKB, UniProtKB]; Study describes a genetic form of noise-induced hearing loss , by showing that pejvakin deficiency in mice and DFNB59 patients leads to hypervulnerability to sound, due to a peroxisomal deficiency., [RefSeq, PubMed]; The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59). [provided by RefSeq, Dec 2008]., [RefSeq]; Two mutations, one in MYO6 (c.554-1 G > A) gene and another in PJVK (c.547C > T) are responsible for 1% each of the Iranian ARNSHL patients, [RefSeq, PubMed]; We have identified a consanguineous family segregating autosomal recessive congenital progressive hearing loss (ARNSHL) and retinal degeneration with central vestibular dysfunction having homozygosity for a DFNB59 mutation., [RefSeq, PubMed]; We identified in Moroccan deaf patients two mutations in PJVK and one mutation in MYO15A described for the first time in association with non-syndromic recessive hearing loss, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PK14;B9EJE2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0035253 ciliary rootlet;GO:0043025 neuronal cell body;GO:0030864 cortical actin cytoskeleton",
        "go_biological_process": "GO:1900063 regulation of peroxisome organization;GO:0007605 sensory perception of sound;GO:0000302 response to reactive oxygen species;GO:0000425 pexophagy;GO:0097468 programmed cell death in response to reactive oxygen species",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q0ZLH3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q00G26-1",
        "uniprot_id": [
            {
                "id": "PLIN5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q00G26",
                "type": "external"
            }
        ],
        "mass": 50791.0,
        "length": 463,
        "protein_name": "Perilipin-5",
        "gene_name": "PLIN5",
        "organism": "Human",
        "refseq_name": "perilipin-5",
        "refseq_ac": [
            {
                "id": "NP_001013728",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013728",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLIN5; LSDP5; OXPAT; PAT-1",
        "gene_names_refseq": "LSDA5; LSDP5; MLDP; OXPAT; PLIN5",
        "protein_names_uniprotkb": "Perilipin-5; Lipid storage droplet protein 5",
        "protein_names_refseq": "lipid storage droplet protein 5; perilipin-5",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:440503)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;17234449;19602560;20166139;21393244;21632259;23129790;24275569;30620550;33160079;35051231;35220055;35401929;36134829;37290445",
        "class_list": "",
        "function": "Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals., [RefSeq, PubMed]; Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I., [RefSeq, PubMed]; Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes., [RefSeq, PubMed]; Interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. Erratum:[J Biol Chem. 2013 Apr 12;288(15):10952. Sreenevasan, Urmilla [corrected to Sreenivasan, Urmila]], [RefSeq, PubMed]; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity)., [UniProtKB, PubMed]; PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport., [RefSeq, PubMed]; Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] Review article, [RefSeq, PubMed]; Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative Tissues. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRC1;Q6ZS68",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0035473 lipase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol",
        "go_biological_process": "GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0010884 positive regulation of lipid storage;GO:0031999 negative regulation of fatty acid beta-oxidation;GO:2000378 negative regulation of reactive oxygen species metabolic process;GO:0060192 negative regulation of lipase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q00G26-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00628-1",
        "uniprot_id": [
            {
                "id": "PEX7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00628",
                "type": "external"
            }
        ],
        "mass": 35892.0,
        "length": 323,
        "protein_name": "Peroxisomal targeting signal 2 receptor",
        "gene_name": "PEX7",
        "organism": "Human",
        "refseq_name": "peroxisomal biogenesis factor 7 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000279",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000279",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX7; PTS2R",
        "gene_names_refseq": "PBD9B; PEX7; PTS2R; RCDP1; RD",
        "protein_names_uniprotkb": "Peroxisomal targeting signal 2 receptor; PTS2 receptor; Peroxin-7",
        "protein_names_refseq": "peroxin-7; peroxisomal PTS2 receptor; peroxisomal biogenesis factor 7 isoform 1; peroxisomal targeting signal 2 receptor; peroxisome targeting signal 2 receptor",
        "tax_id": 9606,
        "disease": "Peroxisome biogenesis disorder 9B (Disease Ontology:DOID:0081438); rhizomelic chondrodysplasia punctata type 1 (Disease Ontology:DOID:0110851); rhizomelic chondrodysplasia punctata (Disease Ontology:DOID:2580)",
        "pathway": " (hsa:5191);  (R-HSA-9033241)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "10022913;10562279;10673331;11101887;11237011;11546814;11781871;11931631;12456682;12522768;12559034;12578380;12717447;12885776;15545321;15858711;16854980;17007944;17726030;18359941;18712838;19197237;19208625;19584060;19632994;20178365;21554508;21976670;21980954;22002062;22057399;22371489;22747494;23963456;24235149;24865970;25016021;25538232;25854684;26086376;26138649;26220973;26344566;26992070;27597759;28218747;28228285;28514659;28521612;28611990;28765278;28787099;28834231;28904123;29242379;29437277;29493099;29557506;30204880;30315122;30410026;30429286;30779550;31154438;31217245;31844290;32157095;32357974;32488085;33298915;33389129;33586206;33633747;33912179;33968037;34357683;34932366;35051231;35251023;35580925;36284347;40739340;7719337;7790377;8824437;8858165;8991089;9090381;9090382;9090383;9539740;9653144;9668159;9837948",
        "class_list": "",
        "function": "Receptor required for the peroxisomal import of proteins containing an N-terminal PTS2-type peroxisomal targeting signal (PubMed:11931631, PubMed:22057399, PubMed:25538232, PubMed:9090381, PubMed:40739340). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (PubMed:11931631, PubMed:22057399, PubMed:25538232). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is translocated into peroxisomes by passing through the PEX13-PEX14 docking complex (PubMed:11546814, PubMed:25538232)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the cytosolic receptor for the set of peroxisomal matrix enzymes targeted to the organelle by the peroxisome targeting signal 2 (PTS2). Defects in this gene cause peroxisome biogenesis disorders (PBDs), which are characterized by multiple defects in peroxisome function. There are at least 14 complementation groups for PBDs, with more than one phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene have been associated with PBD complementation group 11 (PBD-CG11) disorders, rhizomelic chondrodysplasia punctata type 1 (RCDP1), and Refsum disease (RD). [provided by RefSeq, Oct 2008]., [RefSeq]; Twins with PEX7 related intellectual disability and cataract: Highlighting phenotypes of peroxisome biogenesis disorder 9B., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C0H5X6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0005053 peroxisome matrix targeting signal-2 binding",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008611 ether lipid biosynthetic process;GO:0007031 peroxisome organization;GO:0016558 protein import into peroxisome matrix",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "O00628-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43164-1",
        "uniprot_id": [
            {
                "id": "PJA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43164",
                "type": "external"
            }
        ],
        "mass": 78214.0,
        "length": 708,
        "protein_name": "E3 ubiquitin-protein ligase Praja-2",
        "gene_name": "PJA2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase Praja-2",
        "refseq_ac": [
            {
                "id": "NP_055634",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055634",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PJA2; KIAA0438; RNF131",
        "gene_names_refseq": "Neurodap1; PJA2; RNF131",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Praja-2; 2.3.2.27; Praja2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2",
        "protein_names_refseq": "E3 ubiquitin-protein ligase Praja-2; RING-type E3 ubiquitin transferase Praja-2; praja 2, RING-H2 motif containing; praja ring finger 2, E3 ubiquitin protein ligase; praja2; ring finger protein 131",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9867);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10.1101/2023.09.13.557529;11062501;11350924;12036302;12646216;14734113;15224091;15224092;15571818;16595681;16849449;16954532;17081983;18662542;18669648;19028597;19352404;19452197;19489725;19651622;19664994;19690332;19851334;19874575;19940261;20068231;21406692;21423175;2261476;23186163;24275569;24366607;24714562;24715725;25418920;25576301;25880248;26154972;26375851;26728094;26811146;27846572;27862975;27920218;28218747;28228285;28471450;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30429286;30568303;30779550;31154438;31222486;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33461174;33537174;33592498;33691108;33912179;33934390;33936100;33968037;33981976;34087483;34171305;34509645;34932366;35051231;35580925;36010968;36241641;36284347;37938771;38379085;38802340;9380723;9668046",
        "class_list": "",
        "function": "Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways., [RefSeq, PubMed]; Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6U4;D3DSZ5;Q68D49;Q8N1G5",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "O43164-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11678-1",
        "uniprot_id": [
            {
                "id": "PERE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11678",
                "type": "external"
            }
        ],
        "mass": 81040.0,
        "length": 715,
        "protein_name": "Eosinophil peroxidase",
        "gene_name": "EPX",
        "organism": "Human",
        "refseq_name": "eosinophil peroxidase preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000493",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000493",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPX; EPER; EPO; EPP",
        "gene_names_refseq": "EPO; EPP; EPX-PEN; EPXD; EPX",
        "protein_names_uniprotkb": "Eosinophil peroxidase; 1.11.1.7; EPO",
        "protein_names_refseq": "eosinophil peroxidase preproprotein",
        "tax_id": 9606,
        "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); atypical Gaucher's disease due to saposin c deficiency (Disease Ontology:DOID:0110961); combined saposin deficiency (Disease Ontology:DOID:0111330); metachromatic leukodystrophy (Disease Ontology:DOID:10581); Krabbe disease (Disease Ontology:DOID:10587); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415); eosinophil peroxidase deficiency (MONDO:MONDO:0043364)",
        "pathway": " (hsa:8288);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "10358043;10864452;11013238;11112545;12540536;14657871;18694936;23650620;2541222;25418920;2550461;26375851;27587397;29557506;29741879;29789417;30738839;32897882;35051231;37255054;38229400;38316791;38663494;7809065;7852368;8692836",
        "class_list": "",
        "function": "EPX is a useful biomarker for eosinophilic inflammation in chronic rhinosinusitis., [RefSeq, PubMed]; Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status., [RefSeq, PubMed]; Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling., [RefSeq, PubMed]; Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. Publication Status: Online-Only, [RefSeq, PubMed]; Heme-containing oxidoreductase that catalyzes the oxidation of small anions, such as nitrite, halides (e.g bromide and chloride (at pH 6.5)) and pseudohalides (e.g thiocyanate) by using hydrogen peroxide to generate the corresponding reactive species hypobromite, hypochlorite, hypothiocyanous acid, and nitrogen dioxide (PubMed:11013238, PubMed:11112545, PubMed:12540536, PubMed:7852368). Also oxidizes thiocyanate (SCN(-)) to cyanate (OCN(-)) (PubMed:11112545). Functionally involved in inflammatory responses and exhibits antimicrobial activity (PubMed:12540536, PubMed:27587397). Can also oxidize amino acid residues on proteins and generate bromination, nitration and carbamoylation post-translational modifications, respectively (PubMed:18694936, PubMed:27587397). Mediates the nitration of tyrosine (3-nitrotyrosine) which is only observed in secondary granule proteins in mature resting eosinophils in the presence of the cosubstrates, hydrogen peroxide and nitrite (PubMed:18694936). Mediates oxidation of tyrosine residues on proteins in eosinophils to form brominating species, 3-bromotyrosine and 3, 5-dibromotyrosine in the presence of hydrogen peroxide and bromide (By similarity). Promotes protein carbamoylation at sites of inflammation during asthma by using thiocyanate and hydrogen peroxide to form cyanate which carbamoylates lysine residues to form homocitrulline (PubMed:27587397)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 8,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4TVP3",
        "ec_number_list": [
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "2.4.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "1.7.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "5.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9",
                "type": "external"
            },
            {
                "id": "5.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-",
                "type": "external"
            },
            {
                "id": "2.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            },
            {
                "id": "1.13.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "4.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24",
                "type": "external"
            },
            {
                "id": "5.3.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1",
                "type": "external"
            },
            {
                "id": "5.3.3.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            },
            {
                "id": "5.4.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11",
                "type": "external"
            },
            {
                "id": "5.4.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "3.5.4.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5",
                "type": "external"
            },
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1",
                "type": "external"
            },
            {
                "id": "2.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.5.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6",
                "type": "external"
            },
            {
                "id": "1.11.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "1.15.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1",
                "type": "external"
            },
            {
                "id": "1.14.12.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-",
                "type": "external"
            },
            {
                "id": "1.11.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-",
                "type": "external"
            },
            {
                "id": "5.4.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2",
                "type": "external"
            },
            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "4.1.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042742 defense response to bacterium;GO:0042744 hydrogen peroxide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P11678-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000100011000.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P56589-1",
        "uniprot_id": [
            {
                "id": "PEX3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P56589",
                "type": "external"
            }
        ],
        "mass": 42140.0,
        "length": 373,
        "protein_name": "Peroxisomal biogenesis factor 3",
        "gene_name": "PEX3",
        "organism": "Human",
        "refseq_name": "peroxisomal biogenesis factor 3",
        "refseq_ac": [
            {
                "id": "NP_003621",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003621",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX3",
        "gene_names_refseq": "PBD10A; PBD10B; PEX3; TRG18",
        "protein_names_uniprotkb": "Peroxisomal biogenesis factor 3; Peroxin-3; Peroxisomal assembly protein PEX3",
        "protein_names_refseq": "peroxin-3; peroxisomal assembly protein PEX3; peroxisomal biogenesis factor 3; transformation-related protein 18",
        "tax_id": 9606,
        "disease": "peroxisome biogenesis disorder 10A (Disease Ontology:DOID:0080484); Peroxisome biogenesis disorder 10B (Disease Ontology:DOID:0081440); Zellweger syndrome (Disease Ontology:DOID:905)",
        "pathway": " (hsa:8504);  (R-HSA-1369062);  (R-HSA-9603798)",
        "pathway_count": 3,
        "publication_count": 133,
        "publication_id_list": "10.1101/2023.09.13.557529;10430017;10551832;10679269;10704444;10777694;10848631;10873640;10958759;11095984;11099417;11178988;11237011;11248239;11309290;11390669;11402059;11453642;11478798;11590176;11606068;11718719;11883941;12150964;12183068;12504089;12509503;12751901;12821155;12917409;12924628;14570867;14592415;14709540;15007061;15044640;15209530;15713480;15781447;15994327;16007253;16280322;16791427;16895967;16980692;17069900;18174172;18782765;20531392;20554521;21102411;21768384;22624858;22898188;23460677;23481700;23628762;24715725;24831815;25062251;25418920;25517356;25576301;26154972;26768311;26777132;26992070;27557811;27600516;27846572;27862975;27920218;28228285;28281558;28325759;28514659;28832583;28834231;28904123;29242379;29393594;29557506;29632046;29786170;30315122;30379171;30410026;30429286;30779550;31217245;31530632;31611695;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35932552;36010968;36215666;36241641;8411712;8507690;8706931;9345306;9418908;9657383",
        "class_list": "",
        "function": "Hypomorphic mutation of PEX3 with peroxisomal mosaicism reveals the oscillating nature of peroxisome biogenesis coupled with differential metabolic activities., [RefSeq, PubMed]; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FGP5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007031 peroxisome organization;GO:0045046 protein import into peroxisome membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "P56589-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P78562-1",
        "uniprot_id": [
            {
                "id": "PHEX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P78562",
                "type": "external"
            }
        ],
        "mass": 86474.0,
        "length": 749,
        "protein_name": "Phosphate-regulating neutral endopeptidase PHEX",
        "gene_name": "PHEX",
        "organism": "Human",
        "refseq_name": "phosphate-regulating neutral endopeptidase PHEX isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000435",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000435",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHEX; PEX",
        "gene_names_refseq": "HPDR1; HPDR; HYP1; HYP; LXHR; PEX; PHEX; XLH",
        "protein_names_uniprotkb": "Phosphate-regulating neutral endopeptidase PHEX; 3.4.24.-; HYP; Metalloendopeptidase homolog PEX; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein",
        "protein_names_refseq": "PHEX peptidase; X-linked hypophosphatemia protein; metalloendopeptidase homolog PEX; phosphate regulating endopeptidase homolog X-linked; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); phosphate-regulating neutral endopeptidase PHEX isoform 1; phosphate-regulating neutral endopeptidase PHEX; vitamin D-resistant hypophosphatemic rickets protein",
        "tax_id": 9606,
        "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); heart conduction disease (Disease Ontology:DOID:10273); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754)",
        "pathway": " (hsa:5251)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "10439971;10737991;11004247;11237011;12220505;15664000;18162525;18491316;18597632;24190977;28834231;28855257;29242379;29557506;31222486;32983136;35051231;35494241;37074911;37278761;38066669;38442738;38927615;7550339;9070861;9077527;9097956;9106524;9199930;9199999;9593714;9768646;9768674",
        "class_list": "",
        "function": "A Mild Presentation of X-Linked Hypophosphatemia Caused by a Non-Canonical Splice Site Variant in the PHEX Gene. Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation., [RefSeq, PubMed]; Co-occurrence of Spondyloepiphyseal Dysplasia and X-Linked Hypophosphatemia in a Three-Generation Chinese Family., [RefSeq, PubMed]; Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling., [RefSeq, PubMed]; Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:15664000, PubMed:18162525, PubMed:18597632, PubMed:9593714). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18162525, PubMed:18597632). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 9696,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00678;Q13646;Q2M325;Q93032;Q99827",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0036211 protein modification process;GO:1904383 response to sodium phosphate;GO:0006508 proteolysis;GO:0007267 cell-cell signaling;GO:0016485 protein processing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "P78562-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q01970-1",
        "uniprot_id": [
            {
                "id": "PLCB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q01970",
                "type": "external"
            }
        ],
        "mass": 138799.0,
        "length": 1234,
        "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3",
        "gene_name": "PLCB3",
        "organism": "Human",
        "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000923",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000923",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCB3",
        "gene_names_refseq": "PLCB3; SMDCD",
        "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; 3.1.4.11; PLC-beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3",
        "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; PLC beta 3; phosphoinositide phospholipase C-beta-3; phospholipase C, beta 3 (phosphatidylinositol-specific)",
        "tax_id": 9606,
        "disease": "spondylometaphyseal dysplasia with corneal dystrophy (Disease Ontology:DOID:0112303); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:5331);  (R-HSA-112043);  (R-HSA-1855204);  (R-HSA-399997);  (R-HSA-4086398);  (R-HSA-416476);  (R-HSA-418217);  (R-HSA-434316);  (R-HSA-500657)",
        "pathway_count": 9,
        "publication_count": 198,
        "publication_id_list": "10191087;10380924;10391246;10391247;10395542;10488343;10567430;10588714;10593988;10727532;10777564;10858654;10861009;10866302;10893237;11015615;11022047;11022048;11030334;11042108;11118617;11278298;11563835;11588141;11742120;11753430;11909533;12015605;12086864;12120503;12194018;12223481;12471263;12482967;12496284;12556497;12565875;12629551;12729560;12747803;12975316;1322796;1333955;14704854;14977528;15037625;15140260;15143197;1527003;15302935;15316017;15448129;15474001;15494017;15545263;15579586;15611108;15702972;15790568;15914509;15951850;16081037;16107206;16182515;16242307;16268778;16289108;16339447;1644792;16753580;16754659;16871065;16880514;16920709;16923326;17081983;17095603;17101212;17130640;1718960;17395749;17426020;17684012;17900700;17919190;17962409;18322273;18383439;18434541;18450967;18456304;1846707;18488142;18515384;18577758;18606873;18669648;18827341;18936096;1905813;19177143;19179337;19212142;19342380;19398560;19401434;19536106;19651622;19758793;19851316;20007474;20068231;20966218;21118996;21406692;21903638;22223895;22941947;23151663;23186163;23256519;23416699;23632248;23904219;24130766;24275569;2550068;25576301;25892735;26590425;27920218;28228285;2841328;28832583;28834231;28904123;29122926;29393594;29557506;29632046;30429286;30484775;30779550;3086311;31454556;31844290;31848261;32157095;32161166;32350084;32387766;32897882;32938616;33298915;33592498;33968037;33981976;34087483;34509645;34725712;35008409;35051231;35251023;35318648;35580925;36010968;36215666;36241641;37172014;37991948;38665916;38701954;7607669;7612006;7721860;7761412;7890667;7937899;7989336;8132675;8190105;8407970;8454637;8530101;8662638;8664309;8723348;8769125;9073455;9188725;9305846;9360711;9389482;9430698;9593664;9660757;9770463;9808756",
        "class_list": "",
        "function": "Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37172014, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). In conjunction with OSBPL2, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle (PubMed:38701954)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKZ6;G5E960;Q8N1A4",
        "ec_number_list": [
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005516 calmodulin binding;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0016042 lipid catabolic process;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0007208 phospholipase C-activating serotonin receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 20.1,
        "record_id": "Q01970-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13670-1",
        "uniprot_id": [
            {
                "id": "PM2PB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13670",
                "type": "external"
            }
        ],
        "mass": 28555.0,
        "length": 270,
        "protein_name": "Putative postmeiotic segregation increased 2-like protein 11",
        "gene_name": "PMS2P11",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PMS2P11; PMS2L11; PMSR6",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative postmeiotic segregation increased 2-like protein 11; PMS2-related protein 6; Putative postmeiotic segregation increased 2 pseudogene 11",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "30379171;34019948;8586419",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016301 kinase activity",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q13670-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z442-1",
        "uniprot_id": [
            {
                "id": "PK1L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z442",
                "type": "external"
            }
        ],
        "mass": 272514.0,
        "length": 2459,
        "protein_name": "Polycystin-1-like protein 2",
        "gene_name": "PKD1L2",
        "organism": "Human",
        "refseq_name": "polycystin-1-like protein 2 isoform e",
        "refseq_ac": [
            {
                "id": "NP_001265352",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265352",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKD1L2; KIAA1879; PC1L2",
        "gene_names_refseq": "PC1L2; PKD1L2",
        "protein_names_uniprotkb": "Polycystin-1-like protein 2; PC1-like 2 protein; Polycystic kidney disease protein 1-like 2; Polycystin-1L2",
        "protein_names_refseq": "PC1-like 2 protein; polycystic kidney disease 1-like 2; polycystin-1-like protein 2 isoform e; polycystin-1-like protein 2; polycystin-1L2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114780)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;12782129;15203210;19578180;19844255;27605020;28228285;32387766;32488085;34087483;35051231;38253038",
        "class_list": "glycogene",
        "function": "Ectopic expression of PKD1L2 in transgenic mice caused severe muscle atrophy., [RefSeq, PubMed]; Genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores Erratum:[Genomics. 2003 Oct;82(4):498-500], [RefSeq, PubMed]; May function as a G protein-coupled receptor., [UniProtKB, PubMed]; May function as a G-protein-coupled receptor., [UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PKD1L2 is expressed in the developing and adult heart and kidney., [RefSeq, PubMed]; Study found an association between a 6.2 kb dele- tion in the PKD1L2 gene and colorectal cancer in a Korean population., [RefSeq, PubMed]; This gene encodes a member of the polycystin protein family. This protein may function as a G-protein-coupled component or regulator of cation channel pores. The long isoform of this protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene is a polymorphic pseudogene in humans. [provided by RefSeq, May 2022]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 103,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UEE1;Q6ZN46;Q6ZSP2;Q8N1H9;Q96CL2;Q96Q08",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0097708 intracellular vesicle;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0050982 detection of mechanical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q7Z442-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000011000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YI8-1",
        "uniprot_id": [
            {
                "id": "PHF13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YI8",
                "type": "external"
            }
        ],
        "mass": 33582.0,
        "length": 300,
        "protein_name": "PHD finger protein 13",
        "gene_name": "PHF13",
        "organism": "Human",
        "refseq_name": "PHD finger protein 13",
        "refseq_ac": [
            {
                "id": "NP_722519",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722519",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF13",
        "gene_names_refseq": "PHF13; PHF5; SPOC1",
        "protein_names_uniprotkb": "PHD finger protein 13; SPOC1; Survival time-associated PHD finger protein in ovarian cancer 1",
        "protein_names_refseq": "PHD finger protein 13; PHD zinc finger protein PHF5; survival time-associated PHD finger protein in ovarian cancer 1; survival time-associated PHD protein in ovarian cancer",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:148479)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "19638409;23034801;24278021;25576301;26992070;27223324;28218747;28832583;28904123;29021215;29437277;29743358;31217245;31530632;31844290;32157095;32161166;32265295;32890405;32938616;33298915;34171305;35051231;35580925;35597793",
        "class_list": "",
        "function": "High SPOC1 expression is associated with Cytomegalovirus infections. Publication Status: Online-Only, [RefSeq, PubMed]; Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response (PubMed:19638409). Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1 (PubMed:23034801). Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis (PubMed:19638409). Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (PubMed:23034801). Essential for testicular stem-cell differentiation and sustained spermatogenesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; PHF13 epigenetically activates TGFbeta driven epithelial to mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; PHF13 has opposing effects throughout the HIV-1 replication cycle (figure 8). After viral entry and nuclear import of the PIC, PHF13 can increase the number of integrated HIV-1 proviral genomes. After integration, PHF13 acts as antiviral restriction factor and inhibits viral gene expression., [RefSeq, PubMed]; SPOC1 modulates chromatin structure and that tight regulation of its expression levels and subcellular localization during mitosis are crucial for proper chromosome condensation and cell division., [RefSeq, PubMed]; SPOC1-mediated restriction imposed upon Ad growth is relieved by its functional association with the Ad major core protein pVII that enters with the viral genome, followed by E1B-55K/E4orf6-dependent proteasomal degradation of SPOC1., [RefSeq, PubMed]; These experiments showed that PHF13 binds specifically to DNA and to two types of histone H3 methyl tags (lysine 4-tri-methyl or lysine 4-di-methyl) where it functions as a transcriptional co-regulator. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUQ7;Q59FB6;Q5TH65;Q8N551;Q9UJP2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0062072 histone H3K9me2/3 reader activity;GO:0140463 chromatin-protein adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0007076 mitotic chromosome condensation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q86YI8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N414-1",
        "uniprot_id": [
            {
                "id": "PGBD5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N414",
                "type": "external"
            }
        ],
        "mass": 58464.0,
        "length": 524,
        "protein_name": "PiggyBac transposable element-derived protein 5",
        "gene_name": "PGBD5",
        "organism": "Human",
        "refseq_name": "piggyBac transposable element-derived protein 5",
        "refseq_ac": [
            {
                "id": "NP_001245240",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245240",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGBD5",
        "gene_names_refseq": "NEDSHS; PGBD5",
        "protein_names_uniprotkb": "PiggyBac transposable element-derived protein 5; 3.1.-.-; PiggyBac domain-related protein 5; PiggyBac transposase 5",
        "protein_names_refseq": "piggyBac domain related protein 5; piggyBac transposable element-derived protein 5; piggyBac transposase 5",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with seizures, hypotonia, and variable spasticity (Disease Ontology:DOID:0070696)",
        "pathway": " (hsa:79605)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "24180413;26406119;27491780;28504702;30379171;30410026;32387766;32938616;33450253;33592498;34232995;35051231;38517960;38577941;41533792",
        "class_list": "",
        "function": "Childhood cancer mutagenesis caused by transposase-derived PGBD5., [RefSeq, PubMed]; Cognate restriction of transposition by piggyBac-like proteins., [RefSeq, PubMed]; DNA transposition catalyzed by PGBD5 in human cells occurs genome-wide, with precise transposon excision and preference for insertion at TTAA sites. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway., [RefSeq, PubMed]; Previously undefined genomic rearrangements in rhabdoid tumors involved PGBD5-specific signal (PSS) sequences at their breakpoints and recurrently inactivated tumor-suppressor genes. PGBD5 physically associated with genomic PSS sequences mediating PGBD5-induced DNA rearrangements in rhabdoid tumor cells. In immortalized cells, PGBD5 sufficed for transformation via specific catalytic residues in the transposase domain. Erratum:[Nat Genet. 2017 Sep 27;49(10):1558. doi: 10.1038/ng1017-1558b. PMID: 28951624], [RefSeq, PubMed]; The C-terminal Domain of piggyBac Transposase Is Not Required for DNA Transposition. Erratum:[J Mol Biol. 2021 Jul 23;433(15):167089. doi: 10.1016/j.jmb.2021.167089. PMID: 34127257], [RefSeq, PubMed]; The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, May 2010]., [RefSeq]; Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702). Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 23,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MS21;A0PJF3;B4DM72;B7Z9K3;B9EK58;Q5SR37;Q6PJN2;U3REJ1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004803 transposase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0098038 non-replicative DNA transposition",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8N414-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TBY8-2",
        "uniprot_id": [
            {
                "id": "PMFBP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TBY8",
                "type": "external"
            }
        ],
        "mass": 117494.0,
        "length": 1007,
        "protein_name": "Polyamine-modulated factor 1-binding protein 1",
        "gene_name": "PMFBP1",
        "organism": "Human",
        "refseq_name": "polyamine-modulated factor 1-binding protein 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001153685",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153685",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMFBP1",
        "gene_names_refseq": "PMFBP1; SPGF31; STAP",
        "protein_names_uniprotkb": "Polyamine-modulated factor 1-binding protein 1; PMF-1-binding protein",
        "protein_names_refseq": "PMF-1 binding protein; polyamine-modulated factor 1-binding protein 1 isoform b",
        "tax_id": 9606,
        "disease": "spermatogenic failure 31 (Disease Ontology:DOID:0111922); male infertility (Disease Ontology:DOID:12336)",
        "pathway": " (hsa:83449)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11230166;1770140;29557506;30032984;30298696;30379171;30429286;32285443;33484382;34089195;35051231;39894887",
        "class_list": "",
        "function": "A novel homozygous missense mutation of PMFBP1 causes acephalic spermatozoa syndrome., [RefSeq, PubMed]; Novel mutations in PMFBP1, TSGA10 and SUN5: Expanding the spectrum of mutations that may cause acephalic spermatozoa., [RefSeq, PubMed]; Our data indicate that PMFBP1 is necessary for sperm morphology in both humans and mice, and that biallelic truncating mutations in PMFBP1 cause acephalic spermatozoa, [RefSeq, PubMed]; Patients with acephalic spermatozoa syndrome linked to novel TSGA10/PMFBP1 variants have favorable pregnancy outcomes from intracytoplasmic sperm injection., [RefSeq, PubMed]; Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVI9;G3V1Q7;H7BY07;Q8NA09;Q9BY16;Q9H0H4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0061827 sperm head;GO:0005737 cytoplasm;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece;GO:0120212 sperm head-tail coupling apparatus",
        "go_biological_process": "GO:0007283 spermatogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8TBY8-2",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96FX8-1",
        "uniprot_id": [
            {
                "id": "PERP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96FX8",
                "type": "external"
            }
        ],
        "mass": 21386.0,
        "length": 193,
        "protein_name": "p53 apoptosis effector related to PMP-22",
        "gene_name": "PERP",
        "organism": "Human",
        "refseq_name": "p53 apoptosis effector related to PMP-22",
        "refseq_ac": [
            {
                "id": "NP_071404",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071404",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PERP; KCP1; KRTCAP1; PIGPC1; THW",
        "gene_names_refseq": "EKVP7; KCP1; KRTCAP1; OLMS2; PERP; PIGPC1; THW; dJ496H19.1",
        "protein_names_uniprotkb": "p53 apoptosis effector related to PMP-22; KCP-1; Keratinocyte-associated protein 1; P53-induced protein PIGPC1; Transmembrane protein THW",
        "protein_names_refseq": "1110017A08Rik; KCP-1; PERP, TP53 apoptosis effector; keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP-22; p53-induced protein PIGPC1; transmembrane protein THW",
        "tax_id": 9606,
        "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112011); erythrokeratodermia variabilis et progressiva 7 (MONDO:MONDO:0030941); Olmsted syndrome 2 (MONDO:MONDO:0030961)",
        "pathway": " (hsa:64065);  (R-HSA-6803205);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 87,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10733530;10771479;11054413;11062687;11350120;11380615;11590230;11675392;11684014;11714700;11919562;12752121;12902340;1321151;14614825;14729977;15033990;15337775;15377670;15577913;15797384;15803139;15837622;15958553;16061697;16140933;16249378;16303743;16639001;17442733;17515931;17562024;17596512;18532927;18843291;19040420;19190773;19194479;19349281;19549844;20068231;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23059823;23182941;23629652;23671130;24260043;25486861;25576301;25926655;26390218;27078059;27397612;29393594;30321533;30779550;31154438;31361044;31848261;31898316;32161166;32843065;32983136;33034918;33537174;34171305;34863005;35051231;35580925;36010968;7543090;7991565;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22).  Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. Erratum:[Genes Dev 2000 Jul 15;14(14):1835], [RefSeq, PubMed]; Component of intercellular desmosome junctions (By similarity). Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly (By similarity). Thereby plays a role in barrier function of the skin against infection (By similarity). Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions (By similarity). Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis (By similarity). May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4 (By similarity). Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling (By similarity). Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8 (PubMed:25486861). Required for neutrophil transepithelial migration in response to S.typhimurium infection (PubMed:25486861). May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Ichthyosis, psoriasiform dermatitis, and recurrent fungal infections in patients with biallelic mutations in PERP. Review article, [RefSeq, PubMed]; Pilot study of loss of the p53/p63 target gene PERP at the surgical margin as a potential predictor of local relapse in head and neck squamous cell carcinoma., [RefSeq, PubMed]; Upregulation of METTL14 mediates the elevation of PERP mRNA N(6) adenosine methylation promoting the growth and metastasis of pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RB73;E1P590;Q8IWS3;Q8N1J6;Q8NC16;Q9H1C5;Q9H230",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030057 desmosome",
        "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0001894 tissue homeostasis;GO:0006915 apoptotic process;GO:0098609 cell-cell adhesion;GO:0045862 positive regulation of proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q96FX8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96LB9-1",
        "uniprot_id": [
            {
                "id": "PGRP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96LB9",
                "type": "external"
            }
        ],
        "mass": 37611.0,
        "length": 341,
        "protein_name": "Peptidoglycan recognition protein 3",
        "gene_name": "PGLYRP3",
        "organism": "Human",
        "refseq_name": "peptidoglycan recognition protein 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_443123",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443123",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGLYRP3; PGRPIA",
        "gene_names_refseq": "PGLYRP3; PGLYRPIalpha; PGRP-Ialpha; PGRPIA",
        "protein_names_uniprotkb": "Peptidoglycan recognition protein 3; PGLYRPIalpha; PGRP-I-alpha; Peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha",
        "protein_names_refseq": "peptidoglycan recognition protein 3 precursor; peptidoglycan recognition protein I alpha; peptidoglycan recognition protein intermediate alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114771);  (R-HSA-6803157)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "11120840;11313366;11389039;11461926;11971875;12493837;13816;14506276;14739326;15140887;1522221;15229136;15572450;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16641493;16799473;16931762;16940129;17363965;17502600;17567961;17964057;18021746;18160480;18185531;18673279;19095652;19179970;19254208;19818633;20103720;20180804;20382864;20395631;20510021;20845358;21787330;22262861;22327069;22455996;22701042;23302724;23426625;24219363;24256734;25075772;25461571;25596890;26039076;26148048;27089320;29242379;3286634;9523110;9665269;9756476",
        "class_list": "",
        "function": "A significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported. Publication Status: Online-Only, [RefSeq, PubMed]; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity., [UniProtKB, PubMed]; Results describe the function of mammalian antimicrobial peptidoglycan recognition proteins 3 and 4, and show that they are a new class of bactericidal and bacteriostatic proteins., [RefSeq, PubMed]; This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4U8;Q5SY65",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0016019 peptidoglycan immune receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0016045 detection of bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q96LB9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96Q06-1",
        "uniprot_id": [
            {
                "id": "PLIN4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96Q06",
                "type": "external"
            }
        ],
        "mass": 135892.0,
        "length": 1371,
        "protein_name": "Perilipin-4",
        "gene_name": "PLIN4",
        "organism": "Human",
        "refseq_name": "perilipin-4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001354797",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001354797",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLIN4; KIAA1881",
        "gene_names_refseq": "KIAA1881; MDRV; MRUPAV; PLIN4; S3-12",
        "protein_names_uniprotkb": "Perilipin-4; Adipocyte protein S3-12",
        "protein_names_refseq": "adipocyte protein S3-12; muscular dystrophy, with rimmed vacuoles; perilipin-4 isoform 2",
        "tax_id": 9606,
        "disease": "vacuolar Neuromyopathy (MONDO:MONDO:0011155)",
        "pathway": " (hsa:729359);  (R-HSA-9841922)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10425206;10558993;10835357;10882139;11027271;11237011;12829629;12840023;1310260;15111493;16380219;17761950;19043829;19172745;20068230;20495294;28657654;29786170;30293593;30379171;30620550;31537618;32451610;33214551;33329381;33856341;35499779;36151849;37145156;8521497;8521498;9065481;9171241;9744270",
        "class_list": "",
        "function": "Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12., [RefSeq, PubMed]; Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]., [RefSeq]; Multiomic elucidation of a coding 99-mer repeat-expansion skeletal muscle disease., [RefSeq, PubMed]; PLIN4-related myopathy: clinical, histological and imaging data in a large cohort of patients., [RefSeq, PubMed]; These findings underlie the importance of a novel morphologic-metabolic phenotype associated with chemotherapy resistance in triple-negative breast cancer , and bring to light novel therapeutic targets resulting from vulnerabilities in this phenotype, including the expression of PLIN4 essential for stabilizing lipid droplets in resistant cells., [RefSeq, PubMed]; Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. GeneRIF: Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; We investigated whether the presence of the A allele of rs8887 SNP (PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control.  There was a significant interaction between birth weight and the presence of the A allele on SSRT performance,in which lower birth weight associated with poorer inhibitory control only in non-carrier, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NEI2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q96Q06-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HCM2-1",
        "uniprot_id": [
            {
                "id": "PLXA4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HCM2",
                "type": "external"
            }
        ],
        "mass": 212455.0,
        "length": 1894,
        "protein_name": "Plexin-A4",
        "gene_name": "PLXNA4",
        "organism": "Human",
        "refseq_name": "plexin-A4 isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001099013",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099013",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXNA4; KIAA1550; PLXNA4A; PLXNA4B; PRO34003",
        "gene_names_refseq": "FAYV2820; PLEXA4; PLXNA4A; PLXNA4B; PLXNA4; PRO34003",
        "protein_names_uniprotkb": "Plexin-A4",
        "protein_names_refseq": "epididymis secretory sperm binding protein; plexin-A4 isoform 3 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91584);  (R-HSA-399954);  (R-HSA-399955);  (R-HSA-399956);  (R-HSA-416700);  (R-HSA-9615017)",
        "pathway_count": 6,
        "publication_count": 65,
        "publication_id_list": "10.1101/2023.09.13.557529;10075701;10102273;10217147;10358014;10480625;10520995;10559936;10648410;10679438;10913147;10934324;11114375;11276226;11278486;11604131;11779849;12093729;12239572;12372285;12422220;12882840;12975309;14685275;15218527;15550623;15652488;15676027;16286926;16715077;16783365;16840535;16930978;17318185;17607942;17607944;19401682;19608861;21536589;23797096;24028821;24040102;24719461;25548167;25880248;26129650;27547294;28832583;29242379;29557506;30429286;31222486;31844290;32157095;32350084;32387766;32938616;34171305;34185709;34234248;35051231;35163445;35580925;38253038;8955171",
        "class_list": "",
        "function": "An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism. Publication Status: Online-Only, [RefSeq, PubMed]; Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)., [UniProtKB]; Induction of PLXNA4 Gene during Neural Differentiation in Human Umbilical-Cord-Derived Mesenchymal Stem Cells by Low-Intensity Sub-Sonic Vibration. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 87,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1N6;E9PAM2;Q6UWC6;Q6ZW89;Q8N969;Q8ND00;Q8NEN3;Q9NTD4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017154 semaphorin receptor activity",
        "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0150053 cerebellar climbing fiber to Purkinje cell synapse",
        "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0099558 maintenance of synapse structure;GO:0050920 regulation of chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9HCM2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5J5-1",
        "uniprot_id": [
            {
                "id": "PHLA3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5J5",
                "type": "external"
            }
        ],
        "mass": 13891.0,
        "length": 127,
        "protein_name": "Pleckstrin homology-like domain family A member 3",
        "gene_name": "PHLDA3",
        "organism": "Human",
        "refseq_name": "pleckstrin homology-like domain family A member 3",
        "refseq_ac": [
            {
                "id": "NP_036528",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036528",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHLDA3; TIH1",
        "gene_names_refseq": "PHLDA3; TIH1",
        "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1",
        "protein_names_refseq": "TDAG51/Ipl homolog 1; pleckstrin homology-like domain family A member 3; pleckstrin homology-like domain, family A, member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23612)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10594239;15940259;19203586;21753719;24029068;24912192;25667479;27846572;29393594;29557506;30429286;31426686;31492921;31844290;31848261;32938616;33179538;34303965;34592332;35580925",
        "class_list": "",
        "function": "Findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression, [RefSeq, PubMed]; Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt activation may be a therapeutic target in ESCCs, [RefSeq, PubMed]; Novel Role for Pleckstrin Homology-Like Domain Family A, Member 3 in the Regulation of Pathological Cardiac Hypertrophy., [RefSeq, PubMed]; PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell Carcinogenesis., [RefSeq, PubMed]; PHLDA3 exerts an antitumor function in prostate cancer by down-regulating Wnt/beta-catenin pathway via inhibition of Akt., [RefSeq, PubMed]; Phlda3 regulates beta cell survival during stress. Publication Status: Online-Only, [RefSeq, PubMed]; Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer., [RefSeq, PubMed]; Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs)., [RefSeq, PubMed]; Study identifies PHLDA3 as a p53 target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, inhibiting Akt translocation to the cellular membrane and activation., [RefSeq, PubMed]; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5A4;Q53HD6;Q8NBW9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9Y5J5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NEE1-1",
        "uniprot_id": [
            {
                "id": "PLHD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NEE1",
                "type": "external"
            }
        ],
        "mass": 59203.0,
        "length": 506,
        "protein_name": "Pleckstrin homology domain-containing family D member 1",
        "gene_name": "PLEKHD1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family D member 1",
        "refseq_ac": [
            {
                "id": "NP_001154970",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154970",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHD1",
        "gene_names_refseq": "PLEKHD1; UPF0639",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family D member 1; PH domain-containing family D member 1",
        "protein_names_refseq": "PH domain-containing family D member 1; pleckstrin homology domain containing, family D (with M protein repeats) member 1; pleckstrin homology domain containing, family D (with coiled-coil domains) member 1; pleckstrin homology domain-containing family D member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:400224)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "33592498;36215666",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EJC2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A6NEE1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "C9JFL3-1",
        "uniprot_id": [
            {
                "id": "PHGR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/C9JFL3",
                "type": "external"
            }
        ],
        "mass": 7706.0,
        "length": 82,
        "protein_name": "Proline, histidine and glycine-rich protein 1",
        "gene_name": "PHGR1",
        "organism": "Human",
        "refseq_name": "proline, histidine and glycine-rich protein 1",
        "refseq_ac": [
            {
                "id": "NP_001139115",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139115",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHGR1",
        "gene_names_refseq": "PHGR1",
        "protein_names_uniprotkb": "Proline, histidine and glycine-rich protein 1",
        "protein_names_refseq": "proline, histidine and glycine-rich protein 1; proline-histidine-glycin-rich protein 1; proline/histidine/glycine-rich 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:644844)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "29557506;29789417",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "C9JFL3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14813-1",
        "uniprot_id": [
            {
                "id": "PHX2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14813",
                "type": "external"
            }
        ],
        "mass": 29653.0,
        "length": 284,
        "protein_name": "Paired mesoderm homeobox protein 2A",
        "gene_name": "PHOX2A",
        "organism": "Human",
        "refseq_name": "paired mesoderm homeobox protein 2A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005160",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005160",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHOX2A; ARIX; PMX2A",
        "gene_names_refseq": "ARIX; CFEOM2; FEOM2; PHOX2A; PMX2A",
        "protein_names_uniprotkb": "Paired mesoderm homeobox protein 2A; ARIX1 homeodomain protein; Aristaless homeobox protein homolog; Paired-like homeobox 2A",
        "protein_names_refseq": "ARIX1 homeodomain protein; aristaless homeobox homolog; aristaless homeobox protein homolog; arix homeodomain protein; paired mesoderm homeobox protein 2A isoform 1; paired mesoderm homeobox protein 2A",
        "tax_id": 9606,
        "disease": "congenital fibrosis of the extraocular muscles 2 (Disease Ontology:DOID:0081016); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:401)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;11600883;14566559;19564421;26902400;29731959;31541710;33298915;37938771;8661014",
        "class_list": "",
        "function": "May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity)., [UniProtKB, UniProtKB]; Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles., [RefSeq, PubMed]; PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation., [RefSeq, PubMed]; The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3N0;Q8IVZ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021623 oculomotor nerve formation;GO:0048666 neuron development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "O14813-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NYT0-1",
        "uniprot_id": [
            {
                "id": "PLEK2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NYT0",
                "type": "external"
            }
        ],
        "mass": 39971.0,
        "length": 353,
        "protein_name": "Pleckstrin-2",
        "gene_name": "PLEK2",
        "organism": "Human",
        "refseq_name": "pleckstrin-2",
        "refseq_ac": [
            {
                "id": "NP_057529",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057529",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEK2",
        "gene_names_refseq": "PLEK2",
        "protein_names_uniprotkb": "Pleckstrin-2",
        "protein_names_refseq": "pleckstrin 2 homolog; pleckstrin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26499)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;15865208;17008542;18083107;23186163;29789417;30779550;31844290;32157095;33968037;33981976;35051231;36241641;36928924;37591356;37921560;38894536;39069167",
        "class_list": "",
        "function": "May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation., [UniProtKB]; PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25., [RefSeq, PubMed]; PLEK2 mediates metastasis and invasion via alpha5-nAChR activation in nicotine-induced lung adenocarcinoma., [RefSeq, PubMed]; Pleckstrin 2 was cloned; its mRNA is widely expressed in a variety of cell lines., [RefSeq, PubMed]; Pleckstrin-2 Mediates the Activation of AKT in Prostate Cancer and Is Repressed by Androgen Receptor., [RefSeq, PubMed]; Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer., [RefSeq, PubMed]; Pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation., [RefSeq, PubMed]; Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-beta-induced breast cancer cell invasion and metastasis., [RefSeq, PubMed]; The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96JT0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031258 lamellipodium membrane",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0120034 positive regulation of plasma membrane bounded cell projection assembly;GO:0043131 erythrocyte enucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q9NYT0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14494-1",
        "uniprot_id": [
            {
                "id": "PLPP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14494",
                "type": "external"
            }
        ],
        "mass": 32156.0,
        "length": 284,
        "protein_name": "Phospholipid phosphatase 1",
        "gene_name": "PLPP1",
        "organism": "Human",
        "refseq_name": "phospholipid phosphatase 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_003702",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003702",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLPP1; LPP1; PPAP2A",
        "gene_names_refseq": "LLP1a; LPP1; PAP-2a; PAP2; PLPP1; PPAP2A",
        "protein_names_uniprotkb": "Phospholipid phosphatase 1; 3.1.3.-; 3.1.3.106; 3.1.3.4; 3.6.1.75; Lipid phosphate phosphohydrolase 1; PAP-2a; PAP2-alpha; PAP2a; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a",
        "protein_names_refseq": "lipid phosphate phosphohydrolase 1a; phosphatidate phosphohydrolase type 2a; phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A; phosphatidic acid phosphohydrolase type 2a; phospholipid phosphatase 1 isoform 1; type-2 phosphatidic acid phosphatase alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8611);  (R-HSA-9845614)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10962286;11018465;11237011;11356846;12411432;12815058;12909631;14527693;15461590;16782891;16940153;17005594;17379599;17382292;17713573;18558101;18619555;20068046;20089856;20699116;23426360;23721920;23936490;25286108;26992070;27126290;27862975;28832583;29229990;29493099;29557506;30090628;30315122;30429286;30575723;30635364;30779550;30833945;31154438;31844290;31848261;32157095;32350084;32387766;32897882;32938616;33912179;34357683;35051231;35580925;9305923;9468526;9570154;9607309;9705349",
        "class_list": "glycogene",
        "function": "Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:10962286, PubMed:17379599, PubMed:9305923, PubMed:9607309, PubMed:9705349). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association, [RefSeq, PubMed]; The first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 291,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZKN8;G3XA95;O60457;O60463;Q17RZ4",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4",
                "type": "external"
            },
            {
                "id": "3.1.3.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106",
                "type": "external"
            },
            {
                "id": "3.6.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
                "type": "external"
            },
            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0030149 sphingolipid catabolic process;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0019216 regulation of lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "O14494-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000000000.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60331-1",
        "uniprot_id": [
            {
                "id": "PI51C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60331",
                "type": "external"
            }
        ],
        "mass": 73260.0,
        "length": 668,
        "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma",
        "gene_name": "PIP5K1C",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001182662",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182662",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIP5K1C; KIAA0589",
        "gene_names_refseq": "LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5K1C; PIP5Kgamma",
        "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; 2.7.1.68; PIP5K1gamma; PtdIns(4)P-5-kinase 1 gamma; Type I phosphatidylinositol 4-phosphate 5-kinase gamma",
        "protein_names_refseq": "PIP5K1gamma; diphosphoinositide kinase; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; ptdIns(4)P-5-kinase 1 gamma; type I PIP kinase; type I phosphatidylinositol 4-phosphate 5-kinase gamma",
        "tax_id": 9606,
        "disease": "lethal congenital contracture syndrome 3 (Disease Ontology:DOID:0060653); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:23396);  (R-HSA-1660499);  (R-HSA-399955);  (R-HSA-6811558);  (R-HSA-8856828);  (R-HSA-9768727)",
        "pathway_count": 6,
        "publication_count": 291,
        "publication_id_list": "10194451;10224048;10535736;10542231;10555148;10559856;10559861;10559924;10559940;10593988;10625686;10679438;10753883;10766823;10805725;10822173;10934324;11001876;11082044;11084340;11231140;11237011;11239472;11279162;11302699;11349134;11470803;11516654;11517213;11532990;11577110;11604140;11676921;11733541;11877430;11877457;11877461;11889126;11923287;12057195;12101241;12118066;12213833;12324459;12422219;12422220;12447393;12536145;12646134;12808147;12847086;12952949;1325671;14516276;14555962;14581451;14617351;14617813;14622578;14622579;14660569;15080793;15107860;15135396;15252009;15260957;15318165;15339664;15464023;15502812;15502813;15649145;15703209;15716355;15738269;15797027;15802264;15840652;15895077;15916959;16103228;16154996;16215232;16286926;16326391;16399794;16410077;16456541;16476736;16516836;16522682;16707488;16798879;16880396;16903783;16914545;16930978;16979564;17008356;17018281;17035995;17158794;17200115;17245604;17261850;17290217;17494869;17512409;17540576;17609109;17635937;17651088;17681954;17701898;17762867;17765681;17978091;18093523;18388313;1847920;18491227;18753295;18790740;18981233;19038970;19092055;19287005;19296720;19458185;19536138;19548880;19575674;19576174;19603039;19696796;19713939;19776351;19809571;19889969;19896968;20033059;20059951;20211604;20231386;20428113;20448150;20534812;20668706;20826345;20946875;2115402;21187331;21204784;21278753;21316588;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;22037487;22099461;22233676;22375065;22424782;22484487;22505844;22647598;22815487;22863004;22942276;23297414;23481700;23519112;23536704;23758345;23823722;23861397;23891661;24130457;24186068;24581490;24681004;24715725;24789820;24966051;24966173;25107275;25303366;25341920;25495341;25505266;25576301;25588945;25892735;26042225;26154972;26403691;26416966;26811146;26992070;27255086;27397612;27846572;27920218;28063628;28218747;28411811;28512129;28832583;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30429286;30484775;30524438;30555634;31154438;31530632;31844290;31848261;31937595;32157095;32265295;32357974;32387766;32502341;32938616;32983136;33079727;33141586;33298915;33537174;33592498;33912179;33968037;34357683;34932366;35051231;35318648;35580925;36010968;36215666;36241641;37938771;38275211;38452758;6146630;7608176;7624799;7877694;7982500;8524399;8552632;8681945;8723348;8769125;9092476;9094719;9100026;9113989;9211928;9286278;9295334;9367159;9427626;9428629;9514948;9516481;9524259;9535851;9593664;9635431;9660759;9660833;9736607;9811831;9830063",
        "class_list": "",
        "function": "A single homozygous substitution of aspartic acid with asparagine at amino acid 253 in PIP5K1C causes lethal contractural syndrome type 3>, [RefSeq, PubMed]; CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis., [RefSeq, PubMed]; Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Data have identified two novel C-terminal splice variants of PIPKIgamma that are expressed in multiple tissue types, display PIPK activity in vitro abd have distinct subcellular targeting. Publication Status: Online-Only, [RefSeq, PubMed]; Temporal involvement of phosphatidylinositol 4-phosphate 5-kinase gamma in differentiation of Z-bands and myofilament bundles as well as intercalated discs in mouse heart at mid-gestation., [RefSeq, PubMed]; This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]., [RefSeq]; This publication discusses cloning of mouse phosphatidylinositol-4-phosphate 5-kinase type-1 gamma., [RefSeq, PubMed]; Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon., [RefSeq, PubMed]; We show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z9E7;C6GIJ7;C6GIJ8;Q7LE07",
        "ec_number_list": [
            {
                "id": "2.7.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68",
                "type": "external"
            },
            {
                "id": "2.7.1.149",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0052742 phosphatidylinositol kinase activity",
        "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006909 phagocytosis;GO:0061024 membrane organization;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 29.4,
        "record_id": "O60331-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05164-1",
        "uniprot_id": [
            {
                "id": "PERM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05164",
                "type": "external"
            }
        ],
        "mass": 83869.0,
        "length": 745,
        "protein_name": "Myeloperoxidase",
        "gene_name": "MPO",
        "organism": "Human",
        "refseq_name": "myeloperoxidase precursor",
        "refseq_ac": [
            {
                "id": "NP_000241",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000241",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MPO",
        "gene_names_refseq": "MPO",
        "protein_names_uniprotkb": "Myeloperoxidase; 1.11.2.2; 14.5 kDa myeloperoxidase; 59 kDa myeloperoxidase; 75 kDa myeloperoxidase; MPO; Promyeloperoxidase; proMPO",
        "protein_names_refseq": "myeloperoxidase precursor",
        "tax_id": 9606,
        "disease": "lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); bacterial pneumonia (Disease Ontology:DOID:874); status asthmaticus (Disease Ontology:DOID:9362); myeloperoxidase deficiency (MONDO:MONDO:0009694)",
        "pathway": " (hsa:4353);  (R-HSA-6798695);  (R-HSA-8941413)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "37639587;10.1101/2023.09.13.557529;10519157;10766826;10777476;11237011;11705390;12089442;1318692;1334087;15314690;15326314;15498770;15574409;15636586;16091367;16125131;16148002;16335952;16740002;16959974;17074761;17438335;19159218;19402211;19608745;20332087;206633;20974672;20974816;21266577;21297906;21401576;2154223;21880720;22131345;22348603;22352991;22902565;23066164;23549081;23650620;23843990;24049667;24194519;2444596;24736212;25066128;25309750;2552418;25698971;26375851;26992070;27726376;27862975;28187981;2820530;2829220;28348079;28574339;28649674;28657654;28808028;2884926;2903767;29306874;29391424;29557506;29671580;29741879;2981589;30237853;3029127;3031585;3032796;30484775;31291378;31383567;31719144;32125861;32162841;32434865;32897882;32983136;33043033;33091337;33273015;33912179;34171305;34215503;34357683;35051231;35580925;36150500;3654979;37074911;37198333;37776707;37982229;38164522;38432292;38563171;40081572;40596516;40963017;4978299;6095812;6096138;6192815;6295491;7622459;7840679;7904599;8142659;8383257;8385644;8390465;8621627;8692836;9354683;9359420;9450756;9637725;9922160",
        "class_list": "",
        "function": "(Microbial infection) The peroxidase activity is inhibited by S.aureus peroxidase inhibitor SPIN that blocks substrate access to the catalytic heme., [UniProtKB, PubMed, PubMed, PubMed]; Heavy chain of the mature myeloperoxidase., [UniProtKB]; Light chain of the mature myeloperoxidase., [UniProtKB]; Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer., [RefSeq, PubMed]; Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]., [RefSeq]; Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells., [RefSeq, PubMed]; Peroxidase that plays a central role in the host defense system of polymorphonuclear leukocytes by mediating both (1) formation of neutrophil extracellular trap (NETs) and (2) microbicidal activity (PubMed:16125131, PubMed:17438335, PubMed:20974672, PubMed:20974816, PubMed:22131345, PubMed:25066128, PubMed:28574339, PubMed:40963017, PubMed:4978299, PubMed:6295491). Promotes NET formation by mediating chromatin disassembly: translocates to the nucleus and specifically binds to nucleosomes, both as monomer and homodimer, leading to nucleosome unstacking and initial chromatin decondensation (PubMed:40963017). Homodimers clash with one end of the nucleosomal DNA, leading to DNA unwrapping, initiating complete disassembly of nucleosomes and chromatin transformation into NETs in an ATP-independent manner (PubMed:40963017). NETs, which are mainly composed of DNA fibers and globular proteins, are then extruded into the extracellular space by neutrophils to trap pathogens and release antimicrobial proteins to destroy them (PubMed:40963017). Participates to the microbicidal activity against a wide range of organisms by acting as a peroxidase that catalyzes the formation of oxidants in presence of hydrogen peroxide (PubMed:16125131, PubMed:17074761, PubMed:17438335, PubMed:21880720, PubMed:22131345, PubMed:22352991, PubMed:22902565, PubMed:24194519, PubMed:33273015, PubMed:9359420, PubMed:9922160). Mediates the formation of hypohalous acids, mainly hypochlorous acid (HOCl) in physiologic situations, that greatly enhance polymorphonuclear leukocyte microbicidal activity (PubMed:16125131, PubMed:17074761, PubMed:17438335, PubMed:19608745, PubMed:21880720, PubMed:22902565, PubMed:24194519, PubMed:9359420, PubMed:9922160). In addition to hypochlorous acid, catalyzes formation of hypobromous acid (HOBr), hypoiodous acid (HOI) and hypothiocyanous acid (HOSCN) (PubMed:1318692, PubMed:16125131, PubMed:17438335, PubMed:19608745, PubMed:6295491, PubMed:9359420). Also catalyzes oxidation of nitrite into the highly reactive nitrogen dioxide radical (PubMed:10777476, PubMed:8385644, PubMed:9450756). Formation of oxidants are widely believed to be responsible for much of the anti-bactericidal activity of neutrophils (PubMed:8385644, PubMed:9450756). Oxidants, such as hypochlorous acid or nitrogen dioxide radical, can also oxidize amino acid residues on proteins and generate chlorination and nitration post-translational modifications, respectively (PubMed:15314690, PubMed:15326314, PubMed:15498770, PubMed:15574409, PubMed:16091367, PubMed:7622459). Chlorination and nitration of the lipid-free form of APOA1 impairs cholesterol transport (PubMed:15326314, PubMed:15498770, PubMed:15574409). Superoxides generated by MPO can also promote dioxygenation of tryptophan residues on proteins (PubMed:16091367, PubMed:40081572). Also able to oxidize melatonin into N1-acetyl-N2-formyl-5-methoxykynuramine either in presence of hydrogen peroxide or superoxide (PubMed:15636586, PubMed:16148002). Oxidizes urate into 5-hydroxyisourate (PubMed:21266577). Functions as a nitric oxide (NO) oxidase during inflammation, by catalytically consuming NO, impairing NO's ability to maintain vascular tone and function (PubMed:12089442). May also mediate the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases., [RefSeq, PubMed]; [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis]., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 12,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 77,
        "disease_count": 22,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4B8;Q14862;Q4PJH5;Q9UCL7",
        "ec_number_list": [
            {
                "id": "4.6.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19",
                "type": "external"
            },
            {
                "id": "3.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24",
                "type": "external"
            },
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.2.1.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.21.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.16.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5",
                "type": "external"
            },
            {
                "id": "3.4.16.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            },
            {
                "id": "3.1.6.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "3.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
                "type": "external"
            },
            {
                "id": "3.4.21.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.6.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.4.14.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "6.3.4.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21",
                "type": "external"
            },
            {
                "id": "1.8.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "1.11.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-",
                "type": "external"
            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
            },
            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
                "type": "external"
            },
            {
                "id": "3.4.14.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2",
                "type": "external"
            },
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031491 nucleosome binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0070947 neutrophil-mediated killing of fungus;GO:0006952 defense response;GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 21.0,
        "record_id": "P05164-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100100001000.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DJD8-1",
        "uniprot_id": [
            {
                "id": "PEPA3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DJD8",
                "type": "external"
            }
        ],
        "mass": 41976.0,
        "length": 388,
        "protein_name": "Pepsin A-3",
        "gene_name": "PGA3",
        "organism": "Human",
        "refseq_name": "pepsin A-3 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001073275",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073275",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGA3",
        "gene_names_refseq": "PGA3",
        "protein_names_uniprotkb": "Pepsin A-3; 3.4.23.1; Pepsinogen-3",
        "protein_names_refseq": "pepsin A-3 preproprotein; pepsin A-3; pepsinogen 3, group I (pepsinogen A); pepsinogen-3",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:643834);  (R-HSA-5683826)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10368295;10485905;10496952;10580105;10625644;11278984;11563989;12185598;12882447;1325798;1339284;1415726;1568474;15926889;16006481;16199866;1636732;16423266;16630564;17496061;18020944;18692472;1898081;19100526;19144824;1928448;19824815;20054143;20147294;20338813;20418254;23069847;23590306;23684610;23922714;2415509;24743970;2515193;25292040;25424900;2587265;2610270;2714789;29786170;2995821;3037072;31414587;3197840;3366248;34631;34817333;3755136;3801783;4909888;6300126;7597036;7663352;8314870;8428971;8522976;8527267;8636114;9813380",
        "class_list": "",
        "function": "Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Low Pepsinogen I is associated with precancerous gastric lesions., [RefSeq, PubMed]; Serum pepsinogen (PG), gastrin, and Helicobacter pylori (H. pylori) IgG antibodies have become indicators for 'serological biopsy' of the gastric mucosa lesion., [RefSeq, PubMed]; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent., [UniProtKB]; This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K749;B2R7D6;B7ZW75;P00790;Q7M4R0;Q8N1E3",
        "ec_number_list": [
            {
                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
                "type": "external"
            },
            {
                "id": "3.4.23.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity",
        "go_cellular_component": "GO:0070062 extracellular exosome;GO:0097486 multivesicular body lumen",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "P0DJD8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10720-1",
        "uniprot_id": [
            {
                "id": "PF4V_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10720",
                "type": "external"
            }
        ],
        "mass": 11553.0,
        "length": 104,
        "protein_name": "Platelet factor 4 variant",
        "gene_name": "PF4V1",
        "organism": "Human",
        "refseq_name": "platelet factor 4 variant precursor",
        "refseq_ac": [
            {
                "id": "NP_002611",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002611",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PF4V1; CXCL4V1; SCYB4V1",
        "gene_names_refseq": "CXCL4L1; CXCL4V1; PF4-ALT; PF4A; PF4V1; SCYB4V1",
        "protein_names_uniprotkb": "Platelet factor 4 variant; C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1",
        "protein_names_refseq": "C-X-C motif chemokine 4; PF4alt; PF4var1; platelet factor 4 variant precursor; platelet factor 4, variant 1 (PF4-like)",
        "tax_id": 9606,
        "disease": "antiphospholipid syndrome (Disease Ontology:DOID:2988); coronary artery disease (Disease Ontology:DOID:3393); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); retinal degeneration (Disease Ontology:DOID:8466); diabetic retinopathy (Disease Ontology:DOID:8947); acute myocardial infarction (Disease Ontology:DOID:9408)",
        "pathway": " (hsa:5197);  (R-HSA-202733);  (R-HSA-9769739)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "10026158;10606205;10764623;11035113;11207550;11238108;11256994;11564780;11779189;11812992;11833835;12052963;12070135;12208882;12469115;12782713;12907439;14529530;14615387;15000751;15459074;15528364;15681301;15721307;1591491;16161994;1618828;16258728;16297198;16585556;16619025;16691243;16737840;16783819;1695112;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17506785;17525755;17563375;17580308;17598008;17600130;17615384;17625065;17635713;18563170;1902833;19279206;19297154;1930190;20427285;21193412;21659548;21932952;22144186;22618708;2271516;22786881;23536183;23683607;2384594;23945545;24043627;24554904;24764293;2538457;25713144;25855704;2725510;29419409;29557506;29903575;30593538;30918026;31262782;31439947;33912179;35054772;36094626;36951953;3744129;37726033;3863104;468991;6323392;7499257;7509040;7521878;8144529;8163559;8166770;8314844;8639781;9052782;9169774;9218519;9242610;9295288;9382878;9459334;9469622;9693095;9763524",
        "class_list": "",
        "function": "CXCL4 and CXCL4L1 shift the angiogenic/angiostatic balance in favor of angiostasis. CXCL4L1 in particular was found to be a more potent angiostatic, anti-tumoral and anti-metastatic chemokine, which was verified in different in vivo models. Review article, [RefSeq, PubMed]; CXCL4L1 promoter variants may protect against the development of renal inflammation in diabetes by increasing CXCL4L1 expression, which in turn activates the anti-inflammatory SMAD7 and IkappaBalpha factors in mesangial cells., [RefSeq, PubMed]; Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4S0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222 cellular response to lipopolysaccharide;GO:0030593 neutrophil chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P10720-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12273-1",
        "uniprot_id": [
            {
                "id": "PIP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12273",
                "type": "external"
            }
        ],
        "mass": 16572.0,
        "length": 146,
        "protein_name": "Prolactin-inducible protein",
        "gene_name": "PIP",
        "organism": "Human",
        "refseq_name": "prolactin-inducible protein precursor",
        "refseq_ac": [
            {
                "id": "NP_002643",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002643",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIP; GCDFP15; GPIP4",
        "gene_names_refseq": "BRST-2; GCDFP-15; GCDFP15; GPIP4; PIP",
        "protein_names_uniprotkb": "Prolactin-inducible protein; GCDFP-15; Gross cystic disease fluid protein 15; Prolactin-induced protein; SABP; Secretory actin-binding protein; gp17",
        "protein_names_refseq": "SABP; apocrine; gross cystic disease fluid protein 15; prolactin-inducible protein precursor; prolactin-inducible protein; secretory actin-binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5304);  (R-HSA-5223345)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10571941;11326272;11326338;11401429;12297987;12297989;12951058;13130483;14984739;15804357;16740002;16949771;17166836;18057121;18347014;1840603;18780401;18930737;19262752;1955075;19717468;20068231;2013294;22119785;22649030;23090970;23169667;24190977;24725410;24790029;25946035;26620797;26635246;26791533;26824658;27102039;29557506;29741879;29786170;30237853;31468711;31844290;33509033;34171305;34440877;35051231;3667631;37074911;37085653;37938771;4018271;7615546;7619062;7749638;9114041;9218538;9537412",
        "class_list": "",
        "function": "Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells., [RefSeq, PubMed]; Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; The increased vascular wall thickness in pulmonary hypertension secondary to pulmonary fibrosis patients is concomitant with a significantly increased expression of the transcription factor Slug within the macrophages and its target prolactin-induced protein., [RefSeq, PubMed]; Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 75,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A963;A0A9C3;A0A9F3;A4D2I1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0004190 aspartic-type endopeptidase activity;GO:0019864 IgG binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0002682 regulation of immune system process;GO:0070233 negative regulation of T cell apoptotic process;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "P12273-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P53609-1",
        "uniprot_id": [
            {
                "id": "PGTB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P53609",
                "type": "external"
            }
        ],
        "mass": 42368.0,
        "length": 377,
        "protein_name": "Geranylgeranyl transferase type-1 subunit beta",
        "gene_name": "PGGT1B",
        "organism": "Human",
        "refseq_name": "geranylgeranyl transferase type-1 subunit beta",
        "refseq_ac": [
            {
                "id": "NP_005014",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005014",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGGT1B",
        "gene_names_refseq": "BGGI; GGTI; PGGT1B",
        "protein_names_uniprotkb": "Geranylgeranyl transferase type-1 subunit beta; 2.5.1.59; GGTase-I-beta; Geranylgeranyl transferase type I subunit beta; Type I protein geranyl-geranyltransferase subunit beta",
        "protein_names_refseq": "CTC-428G20.3; GGTase-I-beta; geranylgeranyl transferase type I subunit beta; geranylgeranyl transferase type-1 subunit beta; geranylgeranyltransferase type I beta subunit; protein geranylgeranyltransferase type I, beta subunit; type I protein geranyl-geranyltransferase subunit beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5229);  (R-HSA-9953170)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "11687658;14598891;15451670;16511497;20068231;21151871;23481700;25418920;25645385;26154972;26375851;26929215;26992070;27920218;28218747;28514659;28645896;28832583;28834231;28904123;29242379;29437277;29493099;29508533;29557506;29786170;30315122;30410026;30429286;31091448;31217245;31268602;31844290;32357974;32387766;32502341;32510692;32581219;32897882;32938616;32983136;33298915;33548109;33691108;33717175;33876762;33912179;33936100;33968037;34087483;34171305;34211107;34357683;34405274;34932366;35051231;35580925;36010968;37938771;39394410;7512561;8106351;8830800",
        "class_list": "",
        "function": "Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B., [UniProtKB, PubMed]; Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]., [RefSeq]; Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site., [RefSeq, PubMed]; Results suggest that geranylgeranylation of RhoA is critical for cancer cell invasion, [RefSeq, PubMed]; The diagnostic significance of PGGT1B in psoriasis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5MJP9",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.5.1.58",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58",
                "type": "external"
            },
            {
                "id": "2.5.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004661 protein geranylgeranyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex",
        "go_biological_process": "GO:0018344 protein geranylgeranylation;GO:0080120 CAAX-box protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "P53609-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q07326-1",
        "uniprot_id": [
            {
                "id": "PIGF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q07326",
                "type": "external"
            }
        ],
        "mass": 24890.0,
        "length": 219,
        "protein_name": "GPI ethanolamine phosphate transferase, stabilizing subunit",
        "gene_name": "PIGF",
        "organism": "Human",
        "refseq_name": "GPI ethanolamine phosphate transferase, stabilizing subunit isoform 1",
        "refseq_ac": [
            {
                "id": "NP_002634",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002634",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIGF",
        "gene_names_refseq": "OORS; PIGF",
        "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase, stabilizing subunit; GPI ethanolamine phosphate transferase 2, stabilizing subunit; GPI ethanolamine phosphate transferase 3, stabilizing subunit; GPI11 homolog; PIG-F; Phosphatidylinositol-glycan biosynthesis class F protein",
        "protein_names_refseq": "GPI ethanolamine phosphate transferase 2, stabilizing subunit; GPI ethanolamine phosphate transferase 3, stabilizing subunit; GPI ethanolamine phosphate transferase, stabilizing subunit isoform 1; GPI ethanolamine phosphate transferase, stabilizing subunit; GPI11 homolog; PIG-F; phosphatidylinositol-glycan biosynthesis class F protein",
        "tax_id": 9606,
        "disease": "onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome (MONDO:MONDO:0859161)",
        "pathway": " (hsa:5281);  (R-HSA-162710)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10069808;10089216;10944123;11226175;11237011;14517336;14742432;15623507;15632136;15635094;15720390;16162815;24714562;24715725;25576301;25892735;26154972;26728094;28218747;28228285;28832583;28904123;29242379;29437277;29508533;30429286;31844290;31848261;31937595;32157095;32897882;32938616;33386993;35580925;36581221;8463218;8861954;8900170;9463366",
        "class_list": "glycogene",
        "function": "PIGF deficiency causes a phenotype overlapping with DOORS syndrome., [RefSeq, PubMed]; Stabilizing subunit of the ethanolamine phosphate transferase 3 and ethanolamine phosphate transferase 2 complexes that sequentially transfer an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the third alpha-1,2-linked mannose and the second alpha-1,6-linked mannose of a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H8) (PubMed:15632136). Participates in the tenth and eleventh steps of the glycosylphosphatidylinositol-anchor biosynthesis, in association with PIGO and PIGG, respectively (PubMed:15632136, PubMed:33386993)., [UniProtKB, PubMed, PubMed]; This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 297,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WW20",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006506 GPI anchor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q07326-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3MUY2-1",
        "uniprot_id": [
            {
                "id": "PIGY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3MUY2",
                "type": "external"
            }
        ],
        "mass": 8058.0,
        "length": 71,
        "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y",
        "gene_name": "PIGY",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit Y",
        "refseq_ac": [
            {
                "id": "NP_001036081",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036081",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIGY",
        "gene_names_refseq": "HPMRS6; PIG-Y; PIGY",
        "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; PIG-Y; Phosphatidylinositol-glycan biosynthesis class Y protein",
        "protein_names_refseq": "phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; phosphatidylinositol-glycan biosynthesis class Y protein",
        "tax_id": 9606,
        "disease": "hyperphosphatasia with impaired intellectual development syndrome 6 (Disease Ontology:DOID:0070437)",
        "pathway": " (hsa:84992);  (R-HSA-162710)",
        "pathway_count": 2,
        "publication_count": 16,
        "publication_id_list": "10069808;10089216;10944123;11226175;14517336;14742432;15623507;15632136;15635094;15720390;16162815;26293662;34357683;8861954;8900170;9463366",
        "class_list": "glycogene",
        "function": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the catalytic subunit PIGA (PubMed:16162815)., [UniProtKB, PubMed]; The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 79,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006506 GPI anchor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q3MUY2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53GA4-1",
        "uniprot_id": [
            {
                "id": "PHLA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53GA4",
                "type": "external"
            }
        ],
        "mass": 17092.0,
        "length": 152,
        "protein_name": "Pleckstrin homology-like domain family A member 2",
        "gene_name": "PHLDA2",
        "organism": "Human",
        "refseq_name": "pleckstrin homology-like domain family A member 2",
        "refseq_ac": [
            {
                "id": "NP_003302",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003302",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHLDA2; BWR1C; HLDA2; IPL; TSSC3",
        "gene_names_refseq": "BRW1C; BWR1C; HLDA2; IPL; PHLDA2; TSSC3",
        "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 2; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-BWR1C; p17-Beckwith-Wiedemann region 1 C",
        "protein_names_refseq": "beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; imprinted in placenta and liver protein; p17-BWR1C; p17-Beckwith-Wiedemann region 1 C; p17-Beckwith-Wiedemann region 1C; pleckstrin homology-like domain family A member 2; tumor suppressing subchromosomal transferable fragment cDNA 3; tumor suppressing subtransferable candidate 3; tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; tumor-supressing STF cDNA 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7262)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "10594239;10749982;11237011;13129680;15314611;15457853;16584773;16964243;17303335;17322306;18669648;18691976;19203586;20068231;23186163;25576301;27600516;27846572;28832583;29242379;29393594;29493099;31844290;31848261;32157095;32983136;33633747;33968037;33981976;34171305;34561969;35580925;35841528;35894264;36284347;37178619;37298606;38827322;9328465;9403053;9520460",
        "class_list": "",
        "function": "Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole. Publication Status: Online-Only, [RefSeq, PubMed]; FOSL1 transcriptionally regulates PHLDA2 to promote 5-FU resistance in colon cancer cells., [RefSeq, PubMed]; Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway., [RefSeq, PubMed]; PHLDA2 gene is imprinted, with preferential expression from the maternal allele in placenta and liver., [RefSeq, PubMed]; PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity)., [UniProtKB]; RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia., [RefSeq, PubMed]; This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00496",
        "ec_number_list": [],
        "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0001890 placenta development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q53GA4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5SV97-1",
        "uniprot_id": [
            {
                "id": "PERM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5SV97",
                "type": "external"
            }
        ],
        "mass": 81351.0,
        "length": 790,
        "protein_name": "PGC-1 and ERR-induced regulator in muscle protein 1",
        "gene_name": "PERM1",
        "organism": "Human",
        "refseq_name": "PGC-1 and ERR-induced regulator in muscle protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001278295",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278295",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PERM1; C1orf170",
        "gene_names_refseq": "C1orf170; PERM1",
        "protein_names_uniprotkb": "PGC-1 and ERR-induced regulator in muscle protein 1; PPARGC1 and ESRR-induced regulator in muscle 1; Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1",
        "protein_names_refseq": "PGC-1 and ERR-induced regulator in muscle 1; PGC-1 and ERR-induced regulator in muscle protein 1 isoform 1; PPARGC1 and ESRR-induced regulator in muscle 1; pGC-1 and ERR-induced regulator in muscle protein 1; peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84808);  (R-HSA-2151201)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10412986;10643692;10713165;11340167;11809803;12374852;12563009;12745923;15684387;16079181;16079853;16788062;16890199;16908542;16911507;17031457;17437997;17715127;17923681;18215119;18343819;18680753;19001277;19356719;19417006;19951946;23836911;24870542;30862473;32574189;34087483;35051231;39581161;7629110;7799916;8108407;8333869;9178750;9286700",
        "class_list": "",
        "function": "Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1. Publication Status: Online-Only, [RefSeq, PubMed]; Proteomics evidence was identified for the PERM1 gene, [RefSeq, PubMed]; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4., [UniProtKB, UniProtKB]; These findings identify Perm1 as a muscle-specific regulator of exercise-induced signaling and Perm1 levels as tuners of the skeletal muscle response to exercise., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZVZ7;Q9BRF2;S5G239",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0014850 response to muscle activity",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q5SV97-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T9C9-1",
        "uniprot_id": [
            {
                "id": "PI5L1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T9C9",
                "type": "external"
            }
        ],
        "mass": 44572.0,
        "length": 394,
        "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase-like protein 1",
        "gene_name": "PIP5KL1",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001128691",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128691",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIP5KL1",
        "gene_names_refseq": "PIP5KL1; PIPKH",
        "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; PI(4)P 5-kinase-like protein 1; PtdIns(4)P-5-kinase-like protein 1",
        "protein_names_refseq": "PI(4)P 5-kinase-like protein 1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1; phosphatidylinositol phosphate kinase homolog; ptdIns(4)P-5-kinase-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:138429)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "14701839;19680787;29557506;31616009;33968037;35051231",
        "class_list": "",
        "function": "Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Likely functions as a regulatory or scaffold-like protein that modulates the subcellular localization and activity of type I PI(4)P 5-kinases (PIPKs) (By similarity). Lacks intrinsic lipid kinase activity (By similarity)., [UniProtKB, UniProtKB]; PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]., [RefSeq]; PIPKH acts as a scaffold to localize and regulate type I PI(4)P 5-kinases and the synthesis of PI(3,4,5)P(3), [RefSeq, PubMed]; These studies indicate a functional negative correlation between elevated levels of PIP5KL1 and the development of human gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVS3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042995 cell projection",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0030336 negative regulation of cell migration;GO:0010917 negative regulation of mitochondrial membrane potential;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046854 phosphatidylinositol phosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q5T9C9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VZY2-1",
        "uniprot_id": [
            {
                "id": "PLPP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VZY2",
                "type": "external"
            }
        ],
        "mass": 30395.0,
        "length": 271,
        "protein_name": "Phospholipid phosphatase 4",
        "gene_name": "PLPP4",
        "organism": "Human",
        "refseq_name": "phospholipid phosphatase 4 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001025230",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025230",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLPP4; DPPL2; PPAPDC1A; PPAPDC1",
        "gene_names_refseq": "DPPL2; PLPP4; PPAPDC1A; PPAPDC1",
        "protein_names_uniprotkb": "Phospholipid phosphatase 4; 3.1.3.4; 3.6.1.75; Phosphatidic acid phosphatase type 2 domain-containing protein 1A",
        "protein_names_refseq": "diacylglycerol pyrophosphate like 2; diacylglycerol pyrophosphate phosphatase-like 2; phosphatidate phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2 domain containing 1A; phosphatidic acid phosphatase type 2 domain-containing protein 1A; phospholipid phosphatase 4 isoform a",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:196051);  (R-HSA-2029485)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10224668;10579907;11425868;11749377;12660731;12869549;15161916;15294978;15536084;15809313;16497229;16678913;17590538;28851360;29557506;30361512;31844290;32157095;32488085;32938616;33392160;33968037;35051231;36284347;7517665;8228618;8657103;9973503",
        "class_list": "",
        "function": "DPPL1 and DPPL2 represent a novel type of mammalian phosphatidate phosphatase., [RefSeq, PubMed]; Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360)., [UniProtKB, PubMed, PubMed]; PPAPDC1A fusions and in-frame fusions containing a RhoGAP domain clearly define the aggressive subset (7.5%) of diffuse gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Studied the clinical significance and biological roles of PLPP4 in lung carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RU82;Q08EQ2;Q0IIP2;Q495B4;Q5VZY1",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4",
                "type": "external"
            },
            {
                "id": "3.1.3.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106",
                "type": "external"
            },
            {
                "id": "3.6.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
                "type": "external"
            },
            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q5VZY2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q63HM9-1",
        "uniprot_id": [
            {
                "id": "PLCX3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q63HM9",
                "type": "external"
            }
        ],
        "mass": 36313.0,
        "length": 321,
        "protein_name": "PI-PLC X domain-containing protein 3",
        "gene_name": "PLCXD3",
        "organism": "Human",
        "refseq_name": "PI-PLC X domain-containing protein 3",
        "refseq_ac": [
            {
                "id": "NP_001005473",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005473",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCXD3",
        "gene_names_refseq": "PLCXD3",
        "protein_names_uniprotkb": "PI-PLC X domain-containing protein 3",
        "protein_names_refseq": "PI-PLC X domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:345557)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "22732399;25576301;27055460;27486773;27846572;29557506;29741879;29786170;30524438;30620550;32570874",
        "class_list": "",
        "function": "Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population. Publication Status: Online-Only, [RefSeq, PubMed]; One potential miRNA-target gene pair, miR-34c-3p and PLCXD3 (Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 3), was identified in patients with severe oligozoospermia., [RefSeq, PubMed]; We found no supportive evidence that PLCXD3 variants are associated with sporadic Creutzfeldt-Jakob disease. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NL04",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse",
        "go_biological_process": "GO:0007165 signal transduction;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q63HM9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P3X8-1",
        "uniprot_id": [
            {
                "id": "PGBD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P3X8",
                "type": "external"
            }
        ],
        "mass": 68011.0,
        "length": 592,
        "protein_name": "PiggyBac transposable element-derived protein 2",
        "gene_name": "PGBD2",
        "organism": "Human",
        "refseq_name": "piggyBac transposable element-derived protein 2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001017434",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017434",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGBD2",
        "gene_names_refseq": "PGBD2",
        "protein_names_uniprotkb": "PiggyBac transposable element-derived protein 2",
        "protein_names_refseq": "piggyBac transposable element-derived protein 2 isoform b; piggyBac transposable element-derived protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:267002)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "27846572;27862975;27920218;28904123;29557506;30779550;30833945;31154438;31844290;32387766;33298915;35051231;35580925",
        "class_list": "",
        "function": "The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVR8;Q6MZF8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q6P3X8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UQ28-1",
        "uniprot_id": [
            {
                "id": "PLET1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UQ28",
                "type": "external"
            }
        ],
        "mass": 23385.0,
        "length": 207,
        "protein_name": "Placenta-expressed transcript 1 protein",
        "gene_name": "PLET1",
        "organism": "Human",
        "refseq_name": "placenta-expressed transcript 1 protein precursor",
        "refseq_ac": [
            {
                "id": "NP_001138496",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138496",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLET1; C11orf34",
        "gene_names_refseq": "C11orf34; PLET1",
        "protein_names_uniprotkb": "Placenta-expressed transcript 1 protein",
        "protein_names_refseq": "placenta-expressed transcript 1 protein precursor; placenta-expressed transcript 1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:349633);  (R-HSA-163125)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "11072085;15203209;18195351;2443973;31844290;3422494;35051231",
        "class_list": "",
        "function": "Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity)., [UniProtKB]; Plet-1 will thus provide an invaluable tool for genetic analysis of the lineage relationships and molecular mechanisms operating in the development, homeostasis, and injury in several organ/tissue systems, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UQ24;Q6UQ25;Q6UQ27",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0001953 negative regulation of cell-matrix adhesion;GO:0035313 wound healing, spreading of epidermal cells",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q6UQ28-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7RTV0-1",
        "uniprot_id": [
            {
                "id": "PHF5A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7RTV0",
                "type": "external"
            }
        ],
        "mass": 12405.0,
        "length": 110,
        "protein_name": "PHD finger-like domain-containing protein 5A",
        "gene_name": "PHF5A",
        "organism": "Human",
        "refseq_name": "PHD finger-like domain-containing protein 5A",
        "refseq_ac": [
            {
                "id": "NP_116147",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116147",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF5A",
        "gene_names_refseq": "INI; PHF5A; Rds3; SAP14b; SF3B7; SF3b14b; bK223H9.2",
        "protein_names_uniprotkb": "PHD finger-like domain-containing protein 5A; PHD finger-like domain protein 5A; SF3b14b; Splicing factor 3B-associated 14 kDa protein",
        "protein_names_refseq": "PHD finger-like domain protein 5A; PHD finger-like domain-containing protein 5A; PHD-finger 5a; splicing factor 3B associated 14 kDa protein; splicing factor 3b, subunit 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84844);  (R-HSA-72163);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 5,
        "publication_count": 149,
        "publication_id_list": "10199952;10669729;10882114;11014198;11060040;11101529;11233976;11747608;11991638;12054543;12176931;12234937;12411573;12414731;12477934;12682017;12738865;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15146077;15565158;15647753;16263726;16314458;16372014;16809785;17095540;17128255;17332742;17433364;17606899;17717186;18042460;18288197;18322460;18593880;19103666;19165350;19217410;19536130;19608861;20211137;20423332;20695905;20980672;21295486;21536652;2176635;21911577;22046413;22110043;22365833;22569126;22813749;22922743;22959432;22961380;23186163;23222130;23236153;23345524;23874216;24076191;24149845;24196718;24304693;24448447;24714562;24737827;24914973;25301780;25301781;25555158;2558966;26092250;26385511;26420826;26969736;27108190;27377154;27459055;27600516;27661449;27683217;27720643;28062851;28076346;28096519;28502770;28541300;28781166;28911096;29186539;29242379;29274231;29301961;29360106;29361316;29393594;2963332;29902443;30139799;30257008;30315122;30315277;30599162;30705154;30728453;30765414;30975767;31409651;31844290;32179686;32329775;32494006;32816001;32983136;33177556;33214551;33243851;33446560;33509932;34019948;34301950;34822310;35177536;35215846;35385551;36797247;3757028;37845358;38429756;38665916;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28541300, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, PHF5A is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Also involved in elongation by RNA polymerase II as part of the PAF1 complex (PAF1C) (By similarity). PAF1C is required for maintenance of embryonic stem cell (ESC) self-renewal and cellular reprogramming of stem cells (By similarity). Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes (By similarity). Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes (By similarity). Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies (By similarity). Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer. Publication Status: Online-Only, [RefSeq, PubMed]; PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA. Publication Status: Online-Only, [RefSeq, PubMed]; The molecular and genetic research in this paper is performed on mouse but the paper identifies and discusses homologues found in human genomic sequence databases., [RefSeq, PubMed]; This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UH06",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0005686 U2 snRNP",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048863 stem cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 15.2,
        "record_id": "Q7RTV0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z6Z6-1",
        "uniprot_id": [
            {
                "id": "PLPL5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z6Z6",
                "type": "external"
            }
        ],
        "mass": 47912.0,
        "length": 429,
        "protein_name": "Patatin-like phospholipase domain-containing protein 5",
        "gene_name": "PNPLA5",
        "organism": "Human",
        "refseq_name": "patatin-like phospholipase domain-containing protein 5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001171146",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171146",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPLA5; GS2L",
        "gene_names_refseq": "GS2L; PNPLA5; dJ388M5.4; dJ388M5",
        "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 5; 3.1.1.3; GS2-like protein",
        "protein_names_refseq": "GS2-like protein; patatin like phospholipase domain containing 5; patatin-like phospholipase domain-containing protein 5 isoform 2; patatin-like phospholipase domain-containing protein 5",
        "tax_id": 9606,
        "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:150379);  (R-HSA-163560)",
        "pathway_count": 2,
        "publication_count": 16,
        "publication_id_list": "10671541;11237011;12832420;15364929;15456755;16150821;16741517;16799181;17603008;18477386;19181555;19390624;21504868;24613307;29393594;35051231",
        "class_list": "",
        "function": "Has abundant triacylglycerol lipase activity., [UniProtKB, PubMed]; No association between genetic variants in PNPLA5 genes and childhood and adolescent obesity GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Required for optimal autophagy initiation, [RefSeq, PubMed]; This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AHL8;B3KPR1;Q6ZST0",
        "ec_number_list": [
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "3.1.1.116",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004806 triacylglycerol lipase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0055088 lipid homeostasis;GO:0019433 triglyceride catabolic process;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q7Z6Z6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z736-1",
        "uniprot_id": [
            {
                "id": "PKHH3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z736",
                "type": "external"
            }
        ],
        "mass": 85317.0,
        "length": 793,
        "protein_name": "Pleckstrin homology domain-containing family H member 3",
        "gene_name": "PLEKHH3",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family H member 3 isoform X8",
        "refseq_ac": [
            {
                "id": "XP_047292743",
                "url": "https://www.ncbi.nlm.nih.gov/protein/XP_047292743",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHH3",
        "gene_names_refseq": "PLEKHH3",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family H member 3; PH domain-containing family H member 3",
        "protein_names_refseq": "pleckstrin homology domain-containing family H member 3 isoform X8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79990)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;17081983;18669648;24129315;28904123;29437277;29557506;30429286;31844290;32938616;33717175;33936100;33968037;34357683;34509645;34561969;35051231;36215666",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JQ76;Q59H20;Q96B28;Q9H7D6;Q9NT18",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005856 cytoskeleton",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q7Z736-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IWE5-1",
        "uniprot_id": [
            {
                "id": "PKHM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IWE5",
                "type": "external"
            }
        ],
        "mass": 112780.0,
        "length": 1019,
        "protein_name": "Pleckstrin homology domain-containing family M member 2",
        "gene_name": "PLEKHM2",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family M member 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055979",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055979",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHM2; KIAA0842; SKIP",
        "gene_names_refseq": "PLEKHM2; SKIP",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 2; PH domain-containing family M member 2; Salmonella-induced filaments A and kinesin-interacting protein; SifA and kinesin-interacting protein",
        "protein_names_refseq": "PH domain-containing family M member 2; SifA (Salmonella-induced filaments A) and kinesin-interacting protein; novel RUN and PH domain-containing protein; pleckstrin homology domain containing, family M (with RUN domain) member 2; pleckstrin homology domain-containing family M member 2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23207)",
        "pathway_count": 1,
        "publication_count": 63,
        "publication_id_list": "11237011;15905402;18220336;18491316;18669648;18996344;22172677;23481700;24088571;24715725;25418920;25645385;25892735;25898167;26154972;26464484;26811146;26992070;27846572;27920218;28218747;28228285;28325809;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;30315122;30410026;30429286;30524438;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33392160;33936100;33968037;33981976;34211107;34357683;34509645;34932366;35051231;35580925;36010968;36215666;36284347;36717601;36781503;37349842;37938771",
        "class_list": "",
        "function": "A dynamic process of kinesin recruitment in Salmonella-infected cells is down-regulated by the SifA-mediated recruitment of SKIP on membranes [SKIP], [RefSeq, PubMed]; BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain. Publication Status: Online-Only, [RefSeq, PubMed]; Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The association of PLEKHM2 mutation with dilated cardiomyopathy and left ventricular noncompaction supports the importance of autophagy for normal cardiac function., [RefSeq, PubMed]; This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]., [RefSeq]; Two germline mutations can serve as genetic susceptibility screening makers for a lung adenocarcinoma family., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94928;Q5VT65;Q5VVD7;Q6NUH9;Q7L8G1;Q8IVT7;Q8N2T4;Q96AY0;Q9NTF7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0032880 regulation of protein localization;GO:0007030 Golgi organization;GO:0032418 lysosome localization;GO:0042267 natural killer cell mediated cytotoxicity",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q8IWE5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IY17-4",
        "uniprot_id": [
            {
                "id": "PLPL6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IY17",
                "type": "external"
            }
        ],
        "mass": 150954.0,
        "length": 1375,
        "protein_name": "Patatin-like phospholipase domain-containing protein 6",
        "gene_name": "PNPLA6",
        "organism": "Human",
        "refseq_name": "patatin-like phospholipase domain-containing protein 6 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001159583",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159583",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPLA6; NTE",
        "gene_names_refseq": "BNHS; LNMS; NTEMND; NTE; OMCS; PNPLA6; SPG39; iPLA2delta; sws",
        "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 6; 3.1.1.5; Neuropathy target esterase",
        "protein_names_refseq": "neuropathy target esterase; patatin like phospholipase domain containing 6; patatin-like phospholipase domain-containing protein 6 isoform a; patatin-like phospholipase domain-containing protein 6",
        "tax_id": 9606,
        "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia 39 (Disease Ontology:DOID:0110790); Boucher-Neuhauser syndrome (Disease Ontology:DOID:0111265); Oliver-McFarlane syndrome (Disease Ontology:DOID:0111271); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); Laurence-Moon syndrome (Disease Ontology:DOID:1930); hereditary spastic paraplegia (Disease Ontology:DOID:2476)",
        "pathway": " (hsa:10908);  (R-HSA-6814848)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "10.1101/2023.09.13.557529;10760272;11927584;12514188;12576545;15044461;15788404;16472945;1666291;16799181;17015841;18086666;18313024;18667693;18669648;18691976;20068231;23186163;24275569;24355708;25033069;25418920;25480986;25528375;25645385;25892735;28411811;29351928;29493099;29557506;30315122;30410026;30833945;31154438;31222486;31530632;31844290;31848261;32157095;32161166;32265295;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33392160;33592498;33691108;33912179;33968037;34171305;34357683;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36241641;36336212;36581221;37938771;38665916;38683245;38735647;9576844",
        "class_list": "",
        "function": "Neuropathy target esterase activity defines phenotypes among PNPLA6 disorders., [RefSeq, PubMed]; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584)., [UniProtKB, PubMed, PubMed]; The alteration of the expression level of neuropathy target esterase in human neuroblastoma SK-N-SH cells disrupts cellular phospholipids homeostasis., [RefSeq, PubMed]; This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]; Two case reports of a novel missense mutation in the PNPLA6 gene in two siblings with chorioretinal dystrophy, hypogonadotropic hypogonadism, and cerebellar ataxia. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 8,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NGQ0;B4DFB9;B7Z7T2;F5H5K9;J3KQS3;O60859;Q86W58;Q9UG58",
        "ec_number_list": [
            {
                "id": "3.5.1.99",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.56",
                "type": "external"
            },
            {
                "id": "3.1.1.84",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.84",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.3.2.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.111",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0102545 phospholipase B activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0046470 phosphatidylcholine metabolic process;GO:0046475 glycerophospholipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q8IY17-4",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N8W4-1",
        "uniprot_id": [
            {
                "id": "PLPL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N8W4",
                "type": "external"
            }
        ],
        "mass": 57875.0,
        "length": 532,
        "protein_name": "Omega-hydroxyceramide transacylase",
        "gene_name": "PNPLA1",
        "organism": "Human",
        "refseq_name": "omega-hydroxyceramide transacylase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001139188",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139188",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPLA1",
        "gene_names_refseq": "ARCI10; PNPLA1; dJ50J22.1",
        "protein_names_uniprotkb": "Omega-hydroxyceramide transacylase; 2.3.1.296; Patatin-like phospholipase domain-containing protein 1",
        "protein_names_refseq": "omega-hydroxyceramide transacylase isoform 2; omega-hydroxyceramide transacylase; patatin like phospholipase domain containing 1; patatin-like phospholipase domain-containing protein 1",
        "tax_id": 9606,
        "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); autosomal recessive congenital ichthyosis 10 (Disease Ontology:DOID:0060719); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:285848)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;16799181;18414634;19390624;22246504;24344921;27751867;28228285;28248300;28248318;29557506;31092671;31833240;31864761;35051231;35580925;35970721;37458571",
        "class_list": "",
        "function": "Expanding the molecular and clinical spectrum of autosomal recessive congenital ichthyosis caused by pathogenic variants in NIPAL4 and PNPLA1 and evaluation of novel therapeutic interventions., [RefSeq, PubMed]; Homozygous variant p.Ser427Pro in PNPLA1 is a preventive factor from atopic dermatitis., [RefSeq, PubMed]; Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1., [RefSeq, PubMed]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248318). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248318). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:22246504, PubMed:27751867, PubMed:28248318). These lipids also play a role in keratinocyte differentiation (By similarity). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; One missense and one nonsense mutation in the catalytic domain of human PNPLA1 were found in six individuals with autosomal recessive congenital ichthyoses from two families. Publication Status: Online-Only, [RefSeq, PubMed]; PNPLA1 exhibited a modest effect on obesity GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Targeted regions sequencing identified four novel PNPLA1 mutations in two Chinese families with autosomal recessive congenital ichthyosis., [RefSeq, PubMed]; The protein encoded by this gene belongs to the patatin-like phospholipase (PNPLA) family, which is characterized by the presence of a highly conserved patatin domain. PNPLA family members have diverse lipolytic and acyltransferase activities, and are key elements in lipid metabolism. While other members of this family have been well characterized, the function of this gene remained an enigma. However, recent studies show that this gene is expressed in the skin epidermal keratinocytes, and has a role in glycerophospholipid metabolism in the cutaneous barrier. Consistent with these observations, mutations in this gene are associated with ichthyosis in human (autosomal recessive congenital ichthyoses, ARCI) and dog. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A3RMU3;J3JS20;Q2A6N1;Q3SY95;Q3SY96;Q5R3L2",
        "ec_number_list": [
            {
                "id": "2.3.1.296",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.296",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004806 triacylglycerol lipase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0030280 structural constituent of skin epidermis;GO:0106341 omega-hydroxyceramide transacylase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane",
        "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0055088 lipid homeostasis;GO:0019433 triglyceride catabolic process;GO:0106342 omega-hydroxyceramide biosynthetic process;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q8N8W4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96AD5-1",
        "uniprot_id": [
            {
                "id": "PLPL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96AD5",
                "type": "external"
            }
        ],
        "mass": 55316.0,
        "length": 504,
        "protein_name": "Patatin-like phospholipase domain-containing protein 2",
        "gene_name": "PNPLA2",
        "organism": "Human",
        "refseq_name": "patatin-like phospholipase domain-containing protein 2",
        "refseq_ac": [
            {
                "id": "NP_065109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065109",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPLA2; ATGL; FP17548",
        "gene_names_refseq": "1110001C14Rik; ATGL; FP17548; PEDF-R; PNPLA2; TTS-2.2; TTS2; iPLA2zeta",
        "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 2; 3.1.1.3; 3.1.1.4; Adipose triglyceride lipase; Calcium-independent phospholipase A2-zeta; Desnutrin; PEDF-R; Pigment epithelium-derived factor receptor; TTS2.2; TTS2; Transport-secretion protein 2; iPLA2-zeta",
        "protein_names_refseq": "IPLA2-zeta; TTS2.2; adipose triglyceride lipase; calcium-independent phospholipase A2-zeta; calcium-independent phospholipase A2; desnutrin; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain-containing protein 2; pigment epithelium-derived factor receptor; pigment epithelium-derived factor; transport-secretion protein 2.2; triglyceride hydrolase",
        "tax_id": 9606,
        "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970); neutral lipid storage myopathy (MONDO:MONDO:0012545)",
        "pathway": " (hsa:57104);  (R-HSA-1482883);  (R-HSA-381426);  (R-HSA-8957275);  (R-HSA-9841922)",
        "pathway_count": 5,
        "publication_count": 186,
        "publication_id_list": "10.1101/2023.09.13.557529;10026136;10077652;10218588;10425206;10512690;10558993;10614670;10681634;10810289;10835357;10882139;10898936;10912521;10951195;10990447;11027271;11158056;11250653;11264294;11316783;11481335;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12829629;12904166;1310260;1370451;1383255;14521909;15126567;15272052;15308688;15364929;15469690;15485880;15498874;15525596;15550674;15642270;15671038;16106050;16150821;16239926;16249444;16380219;16644682;16705060;17032652;17047378;17187067;17249697;17312271;17603008;17761950;17985932;18452279;18669648;18767875;18991276;19043829;19172745;19651622;19664994;19957260;19962385;20034933;20058876;21068004;21406692;22424782;22713505;22733971;23186163;23297223;24275569;24366607;24715725;2476804;2479552;25576301;26091039;26154972;26811146;26992070;27846572;27862975;27920218;28218747;28228285;28514659;28578400;28832583;28904123;29242379;29351928;29393594;29437277;29493099;29557506;29632711;29786170;29789417;30315122;30410026;30429286;30524438;30779550;31154438;31222486;31530632;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33329381;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34509645;34561969;34903883;35051231;35580925;35676490;36010968;36215666;36241641;36284347;36604676;37217939;37935950;38136930;38413746;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8521497;8521498;8781553;8817670;8894645;8964575;9065481;9171241;9497324;9709957;9733769;9744270;9756920;9786878;9922210",
        "class_list": "",
        "function": "ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids., [RefSeq, PubMed]; ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS., [RefSeq, PubMed]; Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort. Publication Status: Online-Only, [RefSeq, PubMed]; BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; IPLA2epsilon (adiponutrin), iPLA2zeta (TTS-2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols, [RefSeq, PubMed]; Reported that adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis; ATGL and hormone-sensitive lipase (HSL) coordinately catabolize stored triglycerides in adipose tissue [ATGL], [RefSeq, PubMed]; This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 5,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60643;Q5EFF5;Q6XYE5;Q96ET6;Q9NQ61;Q9NQ62",
        "ec_number_list": [
            {
                "id": "1.8.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2",
                "type": "external"
            },
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "1.14.11.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "2.3.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20",
                "type": "external"
            },
            {
                "id": "2.3.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9",
                "type": "external"
            },
            {
                "id": "1.16.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4",
                "type": "external"
            },
            {
                "id": "3.4.21.69",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "3.4.21.112",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112",
                "type": "external"
            },
            {
                "id": "3.1.1.98",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.1.1.116",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.4.1.145",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity;GO:0016411 acylglycerol O-acyltransferase activity;GO:0050253 retinyl-palmitate esterase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0010891 negative regulation of triglyceride storage;GO:0010898 positive regulation of triglyceride catabolic process;GO:0055088 lipid homeostasis;GO:0006651 diacylglycerol biosynthetic process;GO:0019433 triglyceride catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 19.2,
        "record_id": "Q96AD5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96KR7-1",
        "uniprot_id": [
            {
                "id": "PHAR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96KR7",
                "type": "external"
            }
        ],
        "mass": 62552.0,
        "length": 559,
        "protein_name": "Phosphatase and actin regulator 3",
        "gene_name": "PHACTR3",
        "organism": "Human",
        "refseq_name": "phosphatase and actin regulator 3 isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001186434",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186434",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHACTR3; C20orf101; SCAPIN1",
        "gene_names_refseq": "C20orf101; H17739; PHACTR3; PPP1R123; SCAPIN1; SCAPININ",
        "protein_names_uniprotkb": "Phosphatase and actin regulator 3; Scaffold-associated PP1-inhibiting protein; Scapinin",
        "protein_names_refseq": "phosphatase and actin regulator 3 isoform 4; protein phosphatase 1, regulatory subunit 123; scaffold-associated PP1-inhibiting protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116154)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;12925532;16974080;17693683;19158953;19473719;21487013;22135045;26992070;27920218;29242379;29557506;29632046;30779550;31222486;31844290;32157095;32387766;32502341;35051231;38253038",
        "class_list": "",
        "function": "A highly conserved complex genomic organization with four different leader exons; Alternative splicing of exon 5 was found to be limited to human vs. mouse; expression seems to occur predominantly in the brain, [RefSeq, PubMed]; Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain., [RefSeq, PubMed]; DNA methylation of phosphatase and actin regulator 3 is associated with colorectal cancer., [RefSeq, PubMed]; E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses, [RefSeq, PubMed]; Scapinin enhances cell spreading and motility through direct interaction with actin and PP1 plays a regulatory role in scapinin-induced morphological changes, [RefSeq, PubMed]; Scapinin is a putative regulatory subunit of PP1 and is involved in transformed or immature phenotypes of HL-60 cells, [RefSeq, PubMed]; This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AKX0;B1AN68;B1AN69;B2RB46;Q32P33;Q707P6;Q9H4T4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q96KR7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RR1-1",
        "uniprot_id": [
            {
                "id": "PEO1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RR1",
                "type": "external"
            }
        ],
        "mass": 77154.0,
        "length": 684,
        "protein_name": "Twinkle mtDNA helicase",
        "gene_name": "TWNK",
        "organism": "Human",
        "refseq_name": "twinkle mtDNA helicase isoform B",
        "refseq_ac": [
            {
                "id": "NP_001157284",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157284",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TWNK; C10orf2; PEO1",
        "gene_names_refseq": "ATXN8; C10orf2; IOSCA; MTDPS7; PEO1; PEOA3; PEO; PRLTS5; SANDO; SCA8; TWINL; TWNK",
        "protein_names_uniprotkb": "Twinkle mtDNA helicase; 5.6.2.3; Progressive external ophthalmoplegia 1 protein; T7 gp4-like protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase; Twinkle protein, mitochondrial",
        "protein_names_refseq": "T7 gp4-like protein with intramitochondrial nucleoid localization; T7 helicase-related protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase; ataxin 8; progressive external ophthalmoplegia 1 protein; twinkle mtDNA helicase isoform B; twinkle protein, mitochondrial",
        "tax_id": 9606,
        "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 7 (Disease Ontology:DOID:0080126); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3 (Disease Ontology:DOID:0111520); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); Parkinson's disease (Disease Ontology:DOID:14330); Perrault syndrome 5 (MONDO:MONDO:0014504)",
        "pathway": " (hsa:56652);  (R-HSA-2151201);  (R-HSA-9837999);  (R-HSA-9913635)",
        "pathway_count": 4,
        "publication_count": 141,
        "publication_id_list": "10412986;10497183;10608893;10643692;10677218;10713165;11237011;11340167;11431692;11809803;11923310;12163192;12198491;12374852;12557300;12563009;12707443;12745923;12872260;12921794;12975372;14623864;14739292;15167897;15181170;15509589;15522782;15668446;15684387;15870080;16079181;16079853;16115876;16135556;16639411;16788062;16890199;16908542;16911507;17031457;17101804;17297443;17324440;17437997;17579211;17614277;17715127;17722119;17921179;17923681;18039713;18187503;18215119;18343819;18396044;18575922;18680753;18685103;18971204;19001277;19353676;19356719;19417006;19428252;19837034;19841671;19853444;19951946;20445207;20479361;20880070;21953457;22262461;22353293;22383523;22710082;23201127;23931759;24315374;24520911;25355836;25635099;25824949;26253742;26504172;26887820;26923599;27220468;27226550;27496948;27642048;28377575;28396416;28514659;28832583;28904123;29242379;29290614;29301859;29393594;29632046;29932645;30102370;30120231;30247721;30256971;30496414;30605451;30949702;31217245;31327635;31695197;31844290;32157095;32195055;32387766;33257573;33298915;33847964;33981976;34704252;34943861;34950192;35051231;35819194;35870450;35914129;35947649;36528058;36629048;36744436;37013609;37592734;38852317;7623837;7629110;7799916;8108407;8333869;9178750;9286700",
        "class_list": "",
        "function": "A homozygous mutation of TWNK identified in premature ovarian insufficiency warns of late-onset perrault syndrome., [RefSeq, PubMed]; Lack DNA unwinding and ATP hydrolysis activities (PubMed:18039713). Does not bind single-stranded or double-stranded DNA (PubMed:18039713)., [UniProtKB, PubMed]; Mitochondrial helicase involved in mtDNA replication and repair (PubMed:12975372, PubMed:15167897, PubMed:17324440, PubMed:18039713, PubMed:18971204, PubMed:25824949, PubMed:26887820, PubMed:27226550). Might have a role in mtDNA repair (PubMed:27226550). Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB (PubMed:12975372, PubMed:15167897, PubMed:18039713, PubMed:22383523, PubMed:26887820, PubMed:27226550). Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate (PubMed:12975372, PubMed:15167897, PubMed:18039713, PubMed:22383523, PubMed:26887820, PubMed:27226550). Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand (PubMed:27226550). In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities (PubMed:22383523, PubMed:26887820, PubMed:27226550)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural insight and characterization of human Twinkle helicase in mitochondrial disease., [RefSeq, PubMed]; The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase gamma., [RefSeq, PubMed]; This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Aug 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "prognostic",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2CQL2;Q6MZX2;Q6PJP5;Q96RR0",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "3.1.26.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "1.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3",
                "type": "external"
            },
            {
                "id": "1.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3",
                "type": "external"
            },
            {
                "id": "6.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "7.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2",
                "type": "external"
            },
            {
                "id": "4.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2",
                "type": "external"
            },
            {
                "id": "5.6.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7",
                "type": "external"
            },
            {
                "id": "1.2.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1",
                "type": "external"
            },
            {
                "id": "2.3.1.168",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "4.98.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1",
                "type": "external"
            },
            {
                "id": "1.1.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "7.1.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2",
                "type": "external"
            },
            {
                "id": "1.2.1.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36",
                "type": "external"
            },
            {
                "id": "1.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-",
                "type": "external"
            },
            {
                "id": "1.2.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "1.1.1.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37",
                "type": "external"
            },
            {
                "id": "5.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8",
                "type": "external"
            },
            {
                "id": "1.3.8.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1",
                "type": "external"
            },
            {
                "id": "1.3.8.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "2.3.3.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10",
                "type": "external"
            },
            {
                "id": "2.8.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.2.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "1.1.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35",
                "type": "external"
            },
            {
                "id": "2.7.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "1.1.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62",
                "type": "external"
            },
            {
                "id": "1.1.1.239",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239",
                "type": "external"
            },
            {
                "id": "1.1.1.178",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178",
                "type": "external"
            },
            {
                "id": "1.1.1.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53",
                "type": "external"
            },
            {
                "id": "1.1.1.159",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159",
                "type": "external"
            },
            {
                "id": "4.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "6.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5",
                "type": "external"
            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0002020 protease binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0000262 mitochondrial chromosome",
        "go_biological_process": "GO:0006264 mitochondrial DNA replication;GO:0006261 DNA-templated DNA replication;GO:0034214 protein hexamerization;GO:0006390 mitochondrial transcription;GO:0006260 DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 14.2,
        "record_id": "Q96RR1-1",
        "record_type": "protein",
        "filter_code": "0001000.1100111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BY49-1",
        "uniprot_id": [
            {
                "id": "PECR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BY49",
                "type": "external"
            }
        ],
        "mass": 32544.0,
        "length": 303,
        "protein_name": "Peroxisomal trans-2-enoyl-CoA reductase",
        "gene_name": "PECR",
        "organism": "Human",
        "refseq_name": "peroxisomal trans-2-enoyl-CoA reductase",
        "refseq_ac": [
            {
                "id": "NP_060911",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060911",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PECR; PRO1004; SDR29C1",
        "gene_names_refseq": "DCRRP; HPDHASE; HSA250303; PECR; PVIARL; SDR29C1; TERP",
        "protein_names_uniprotkb": "Peroxisomal trans-2-enoyl-CoA reductase; 1.3.1.38; 2,4-dienoyl-CoA reductase-related protein; DCR-RP; HPDHase; Short chain dehydrogenase/reductase family 29C member 1; TERP; pVI-ARL",
        "protein_names_refseq": "2,4-dienoyl-CoA reductase-related protein; DCR-RP; pVI-ARL; peroxisomal trans-2-enoyl-CoA reductase; putative short chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 29C member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55825);  (R-HSA-389599);  (R-HSA-9033241)",
        "pathway_count": 3,
        "publication_count": 96,
        "publication_id_list": "10022913;10198260;10468558;10562279;10673331;10811639;11101887;11546814;11555634;11669066;11781871;11931631;11937624;12445829;12456682;12559034;12578380;12717447;12885776;15545321;15858711;16186124;16546181;16756494;16854980;17007944;17726030;18083107;18359941;18712838;19197237;19208625;19584060;19632994;20178365;20463177;20558530;21554508;21976670;21980954;22002062;22057399;22371489;22745130;22747494;23963456;24235149;24275569;24714562;24865970;25016021;25538232;25576301;25854684;26086376;26138649;26220973;26344566;26728094;27597759;27600516;28228285;28521612;28611990;28765278;28787099;28904123;29242379;29557506;30315122;30379171;30429286;31844290;31998317;32938616;33482198;34171305;35051231;36241641;38253038;40596516;7719337;7790377;8824437;8858165;8991089;9090381;9090382;9090383;9166898;9539740;9653144;9662422;9668159;9837948;9874197",
        "class_list": "",
        "function": "Biochemical studies and structural analysis suggest that pDCRs can catalyze the shortening of six-carbon-long substrates in vitro., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity., [UniProtKB, PubMed]; Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RE42;Q53TC4;Q6IAK9;Q9NRD4;Q9NY60;Q9P1A4",
        "ec_number_list": [
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "6.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7",
                "type": "external"
            },
            {
                "id": "6.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24",
                "type": "external"
            },
            {
                "id": "6.2.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42",
                "type": "external"
            },
            {
                "id": "1.3.3.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "3.4.24.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56",
                "type": "external"
            },
            {
                "id": "1.4.3.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3",
                "type": "external"
            },
            {
                "id": "2.6.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51",
                "type": "external"
            },
            {
                "id": "2.6.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44",
                "type": "external"
            },
            {
                "id": "2.3.1.176",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "4.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4",
                "type": "external"
            },
            {
                "id": "2.3.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137",
                "type": "external"
            },
            {
                "id": "2.3.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7",
                "type": "external"
            },
            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.5.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "1.4.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1",
                "type": "external"
            },
            {
                "id": "1.1.1.184",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184",
                "type": "external"
            },
            {
                "id": "1.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38",
                "type": "external"
            },
            {
                "id": "1.3.1.124",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124",
                "type": "external"
            },
            {
                "id": "1.1.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15",
                "type": "external"
            },
            {
                "id": "1.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1",
                "type": "external"
            },
            {
                "id": "1.5.3.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7",
                "type": "external"
            },
            {
                "id": "5.1.99.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4",
                "type": "external"
            },
            {
                "id": "4.1.2.63",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63",
                "type": "external"
            },
            {
                "id": "1.2.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity;GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0033306 phytol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q9BY49-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H490-1",
        "uniprot_id": [
            {
                "id": "PIGU_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H490",
                "type": "external"
            }
        ],
        "mass": 50052.0,
        "length": 435,
        "protein_name": "GPI-anchor transamidase component PIGU",
        "gene_name": "PIGU",
        "organism": "Human",
        "refseq_name": "GPI-anchor transamidase component PIGU",
        "refseq_ac": [
            {
                "id": "NP_536724",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536724",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIGU; CDC91L1; PRO9875; PSEC0205",
        "gene_names_refseq": "CDC91L1; GAB1; GPIBD21; NEDBSS; PIG-U; PIGU",
        "protein_names_uniprotkb": "GPI-anchor transamidase component PIGU; Cell division cycle protein 91-like 1; GPI transamidase component PIG-U; Phosphatidylinositol glycan anchor biosynthesis class U protein; Protein CDC91-like 1",
        "protein_names_refseq": "CDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1; GPI and Actin Bar homolog; GPI transamidase component PIG-U; GPI transamidase subunit PIGU; GPI transamidase subunit; GPI-anchor transamidase component PIGU; cell division cycle 91-like 1 protein; cell division cycle protein 91-like 1; phosphatidylinositol glycan anchor biosynthesis class U protein; protein CDC91-like 1",
        "tax_id": 9606,
        "disease": "glycosylphosphatidylinositol biosynthesis defect 21 (MONDO:MONDO:0032824)",
        "pathway": " (hsa:128869);  (R-HSA-162791)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "11237011;11483512;12802054;12975309;16303743;23481700;24715725;25418920;25892735;26992070;27846572;28218747;28228285;28514659;28832583;28904123;29242379;29557506;29769354;29786170;30315122;30429286;30524438;30779550;30833945;31154438;31217245;31353022;31530632;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32971102;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34185709;34211107;34357683;34509645;34576938;34725712;34932366;35051231;35154160;35165458;35551457;35580925;36010968;36215666;36241641;36284347;37217939;37684232;9356492",
        "class_list": "glycogene",
        "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:12802054, PubMed:31353022, PubMed:34576938, PubMed:35165458, PubMed:35551457, PubMed:37684232). Binds the lipid portion of GPI-anchor (PubMed:37684232). May act as an organizer in the transmembrane layer to recruit other subunits, and thus is essential for assembly of the complex (PubMed:35165458, PubMed:35551457)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit. Publication Status: Online-Only, [RefSeq, PubMed]; PIGU promotes hepatocellular carcinoma progression through activating NF-kappaB pathway and increasing immune escape., [RefSeq, PubMed]; The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 477,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z489;Q8N2F2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0003923 GPI-anchor transamidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042765 GPI-anchor transamidase complex",
        "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9H490-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H611-1",
        "uniprot_id": [
            {
                "id": "PIF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H611",
                "type": "external"
            }
        ],
        "mass": 69799.0,
        "length": 641,
        "protein_name": "ATP-dependent DNA helicase PIF1",
        "gene_name": "PIF1",
        "organism": "Human",
        "refseq_name": "ATP-dependent DNA helicase PIF1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001273425",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273425",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIF1; C15orf20",
        "gene_names_refseq": "C15orf20; PIF1; PIF",
        "protein_names_uniprotkb": "ATP-dependent DNA helicase PIF1; 5.6.2.3; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1; PIF1/RRM3 DNA helicase-like protein",
        "protein_names_refseq": "ATP-dependent DNA helicase PIF1 isoform a; ATP-dependent DNA helicase PIF1; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1; PIF1 5'-to-3' DNA helicase homolog; PIF1/RRM3 DNA helicase-like protein; petite integration frequency 1",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); progeria (Disease Ontology:DOID:3911)",
        "pathway": " (hsa:80119);  (R-HSA-171319)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "12699629;15060173;15189140;16339074;16522649;17172855;17395830;17827721;18358808;18523010;18669648;18835853;19179534;19383767;19664994;19664995;19700773;19734544;20068231;20404094;20524933;21406692;21993680;22347400;22579284;23103865;23186163;23275553;23657261;24714562;25128433;25271372;25418920;25620558;26811146;26992070;27920218;28228285;28832583;28904123;29178645;29242379;29393594;29632046;29695869;30315122;31154438;31217245;31723267;31844290;32387766;32502341;32897882;33141586;33298915;33470420;33592498;33691108;33717175;33936100;33968037;34509645;35051231;35190532;37396201",
        "class_list": "",
        "function": "CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Evidence that the PIF1 N-terminal (PINT) domain as crucial functions in PIF1 helicase., [RefSeq, PubMed]; HPif1 in the nucleus may be involved in chromosome maintenance in association with DNA replication, [RefSeq, PubMed]; HPif1 may regulate telomere elongation by decreasing telomerase processivity, possibly via a mechanism that involves the unwinding of telomerase RNA from telomeric DNA by hPif1. Publication Status: Online-Only, [RefSeq, PubMed]; Human PIF, like S. cerevisiae Pif1p, plays a role in telomerase regulation., [RefSeq, PubMed]; PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; PIF1 helicase promotes break-induced replication in mammalian cells., [RefSeq, PubMed]; This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPL7;Q1W5B6;Q330H5;Q33E24",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "5.4.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding;GO:0051880 G-quadruplex DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0000781 chromosome, telomeric region",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0007004 telomere maintenance via telomerase;GO:0001117 protein-DNA-RNA complex disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q9H611-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H814-1",
        "uniprot_id": [
            {
                "id": "PHAX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H814",
                "type": "external"
            }
        ],
        "mass": 44403.0,
        "length": 394,
        "protein_name": "Phosphorylated adapter RNA export protein",
        "gene_name": "PHAX",
        "organism": "Human",
        "refseq_name": "phosphorylated adapter RNA export protein",
        "refseq_ac": [
            {
                "id": "NP_115553",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115553",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHAX; RNUXA",
        "gene_names_refseq": "PHAX; RNUXA",
        "protein_names_uniprotkb": "Phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein",
        "protein_names_refseq": "RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adapter (phosphorylation regulated); RNA U, small nuclear RNA export adaptor (phosphorylation regulated); phosphorylated adapter RNA export protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51808);  (R-HSA-191859);  (R-HSA-6807505)",
        "pathway_count": 3,
        "publication_count": 99,
        "publication_id_list": "10022900;10531003;10556282;10601333;10725331;10851237;11333016;11714716;11748230;11856838;12065586;12095920;12414730;12441251;12574128;12776181;14701755;1535687;15574332;15574333;16239144;16308568;16901896;1739980;17525332;18079403;1829677;18669648;19651622;19667075;20068231;20430857;20457598;2125285;21406692;22137580;22231121;22252320;22441827;23166507;23186163;23301498;23481700;23932780;24097444;24270878;24275569;24715725;24997600;25675981;25880248;26154972;26382858;26758079;27920218;28228285;28649982;28832583;28904123;29242379;2944599;29557506;29632046;29632711;30429286;30833945;31530632;31844290;31848261;32157095;32265295;32759388;32938616;33298915;33592498;33691108;33717175;33912179;33968037;34019948;35051231;35132862;36010968;38828688;40136647;40914422;7715707;8196654;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505;9845364",
        "class_list": "",
        "function": "A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA., [UniProtKB, PubMed, PubMed]; PHAX RNA-binding domain mediates auxiliary RNA contracts with small nuclear and mall nucleolar RNA substrates., [RefSeq, PubMed]; PHAX and CRM1 have roles in transporting U3 snoRNA to nucleoli, [RefSeq, PubMed]; TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs., [RefSeq, PubMed]; The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H8W1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0015643 toxic substance binding;GO:0140262 mRNA cap binding complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0015030 Cajal body",
        "go_biological_process": "GO:0015031 protein transport;GO:0006408 snRNA export from nucleus;GO:0043489 RNA stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q9H814-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRY7-2",
        "uniprot_id": [
            {
                "id": "PLS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRY7",
                "type": "external"
            }
        ],
        "mass": 33504.0,
        "length": 297,
        "protein_name": "Phospholipid scramblase 2",
        "gene_name": "PLSCR2",
        "organism": "Human",
        "refseq_name": "phospholipid scramblase 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001186907",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186907",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLSCR2",
        "gene_names_refseq": "PLSCR2",
        "protein_names_uniprotkb": "Phospholipid scramblase 2; Ca(2+)-dependent phospholipid scramblase 2; PL scramblase 2",
        "protein_names_refseq": "PL scramblase 2; ca(2+)-dependent phospholipid scramblase 2; phospholipid scramblase 2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57047)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10930526;19540310;23481700;24648509;25576301;27600516;29242379;29786170;30524438;31154438;31937595;32938616;32983136;33298915;33912179;34509645;35051231;35580925;36010968",
        "class_list": "",
        "function": "HPLSCR1 and PRD-hPLSCR2 showed Ca(2+)-dependent aggregation and scrambling activity, [RefSeq, PubMed]; Has no phospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain., [UniProtKB, PubMed]; May catalyze calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane., [UniProtKB, PubMed]; Results show that binding affinities of the peptides are in the order hPLSCR1>hPLSCR3>hPLSCR2>hPLSCR4 for Ca2+ and in the order hPLSCR1>hPLSCR2>hPLSCR3>hPLSCR4 for Mg2+., [RefSeq, PubMed]; This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DXC3;J3KR76;Q0VAQ1;Q6NSW9;Q7Z4L7",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0017128 phospholipid scramblase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0017121 plasma membrane phospholipid scrambling;GO:0045089 positive regulation of innate immune response;GO:0070782 phosphatidylserine exposure on apoptotic cell surface",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9NRY7-2",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0J9YX94-1",
        "uniprot_id": [
            {
                "id": "PMA6F_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0J9YX94",
                "type": "external"
            }
        ],
        "mass": 60071.0,
        "length": 578,
        "protein_name": "Paraneoplastic antigen Ma6F",
        "gene_name": "PNMA6F",
        "organism": "Human",
        "refseq_name": "paraneoplastic antigen Ma6F",
        "refseq_ac": [
            {
                "id": "NP_001341909",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341909",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNMA6F; PNMA6BL",
        "gene_names_refseq": "PNMA6BL; PNMA6F",
        "protein_names_uniprotkb": "Paraneoplastic antigen Ma6F",
        "protein_names_refseq": "paraneoplastic Ma antigen family member 6F; paraneoplastic antigen Ma6F; paraneoplastic antigen-like protein 6B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:105373377)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "32938616;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A0A0J9YX94-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0PG75-1",
        "uniprot_id": [
            {
                "id": "PLS5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0PG75",
                "type": "external"
            }
        ],
        "mass": 30027.0,
        "length": 271,
        "protein_name": "Phospholipid scramblase family member 5",
        "gene_name": "PLSCR5",
        "organism": "Human",
        "refseq_name": "phospholipid scramblase family member 5 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001078889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLSCR5",
        "gene_names_refseq": "PLSCR5",
        "protein_names_uniprotkb": "Phospholipid scramblase family member 5",
        "protein_names_refseq": "phospholipid scramblase family member 5 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389158)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "23481700;29557506;33392160;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RXK5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017128 phospholipid scramblase activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0017121 plasma membrane phospholipid scrambling",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "A0PG75-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZF1-1",
        "uniprot_id": [
            {
                "id": "PLAC8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZF1",
                "type": "external"
            }
        ],
        "mass": 12507.0,
        "length": 115,
        "protein_name": "Placenta-specific gene 8 protein",
        "gene_name": "PLAC8",
        "organism": "Human",
        "refseq_name": "placenta-specific gene 8 protein",
        "refseq_ac": [
            {
                "id": "NP_001124187",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124187",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAC8; BM-004",
        "gene_names_refseq": "C15; DGIC; PLAC8; PNAS-144; onzin",
        "protein_names_uniprotkb": "Placenta-specific gene 8 protein; Protein C15",
        "protein_names_refseq": "down-regulated in gastrointestinal cancer protein; placenta specific 8; placenta-specific gene 8 protein",
        "tax_id": 9606,
        "disease": "glucose intolerance (Disease Ontology:DOID:10603)",
        "pathway": " (hsa:51316);  (R-HSA-6798695);  (R-HSA-9830364)",
        "pathway_count": 3,
        "publication_count": 16,
        "publication_id_list": "11237011;12384430;20072156;22920440;23650620;25502872;25892735;28832583;29242379;29393594;36124427;36543379;36602585;37885015;38441011;8692836",
        "class_list": "",
        "function": "Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells., [RefSeq, PubMed]; Data suggest that overexpression of PLAC8 induces apoptosis in some cells (CEM-C7 cells; Jurkat T cells); expression of PLAC8 has anti-apoptosis effect in other cells (adherent cell lines; HEK293T cells; MCF-10A cells)., [RefSeq, PubMed]; Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis., [RefSeq, PubMed]; Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer., [RefSeq, PubMed]; PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway., [RefSeq, PubMed]; Phorbol 12-myristate 13-acetate(PMA)downregulates onzin expression through PKCepsilon-ERK2 signaling pathway, which favors monocytic differentiation of leukemic cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C1K3N2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0120162 positive regulation of cold-induced thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9NZF1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60486-1",
        "uniprot_id": [
            {
                "id": "PLXC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60486",
                "type": "external"
            }
        ],
        "mass": 175742.0,
        "length": 1568,
        "protein_name": "Plexin-C1",
        "gene_name": "PLXNC1",
        "organism": "Human",
        "refseq_name": "plexin-C1 precursor",
        "refseq_ac": [
            {
                "id": "NP_005752",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005752",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXNC1; VESPR",
        "gene_names_refseq": "CD232; PLXN-C1; PLXNC1; VESPR",
        "protein_names_uniprotkb": "Plexin-C1; Virus-encoded semaphorin protein receptor",
        "protein_names_refseq": "plexin (semaphorin receptor); plexin-C1 precursor; receptor for viral semaphorin protein; receptor for virally-encoded semaphorin; virus-encoded semaphorin protein receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10154);  (R-HSA-416700)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "10.1101/2023.09.13.557529;10520995;10648410;11114375;11237011;12882840;15218527;15550623;16715077;17081983;17318185;17671519;18452278;20727575;22424782;22544926;23345538;23481700;24190977;24715725;25502872;25576301;25645385;25892735;26154972;26811146;26992070;27600516;27726376;27846572;27920218;28218747;28228285;28467828;28514659;28832583;28904123;29242379;29314611;29393594;29437277;29493099;29508533;29557506;29632046;29741879;29769354;29786170;30315122;30429286;31154438;31317324;31844290;32157095;32350084;32357974;32387766;32502341;32983136;33141586;33298915;33656690;33912179;33936100;34211107;34357683;34509645;34561969;34932366;35051231;35154160;35580925;37074911;37217939;37853395;37938771;38678170;41350704;8955171;9586637",
        "class_list": "",
        "function": "GTP-bound form of Rab7 promotes melanogenesis through the regulation of gp100 maturation in melanoma cells., [RefSeq, PubMed]; PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1beta-exposed chondrocytes via suppressing GRP78 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity)., [UniProtKB, PubMed]; Results indicated that PLXNC1 was a direct target of miR-4500. Its knockdown inhibits proliferation and invasion of papillary thyroid cancer (PTC) cells. On the contrary, its overexpression of impairs miR-4500-induced inhibition of PTC malignancy., [RefSeq, PubMed]; Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin beta1 in Kawasaki disease. Publication Status: Online-Only, [RefSeq, PubMed]; The Relationship Between Plexin C1 Overexpression and Survival in Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Study., [RefSeq, PubMed]; This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 15,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 12,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 16,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 16,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 76,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 30,
        "disease_count": 0,
        "glyco_site_count": 22,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q59H25",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0017154 semaphorin receptor activity",
        "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0150053 cerebellar climbing fiber to Purkinje cell synapse",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "O60486-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A1B0GUJ8-1",
        "uniprot_id": [
            {
                "id": "PNM8C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A1B0GUJ8",
                "type": "external"
            }
        ],
        "mass": 22873.0,
        "length": 204,
        "protein_name": "Paraneoplastic antigen-like protein 8C",
        "gene_name": "PNMA8C",
        "organism": "Human",
        "refseq_name": "paraneoplastic antigen-like protein 8C",
        "refseq_ac": [
            {
                "id": "NP_001373722",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373722",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNMA8C",
        "gene_names_refseq": "PNMA8C",
        "protein_names_uniprotkb": "Paraneoplastic antigen-like protein 8C",
        "protein_names_refseq": "paraneoplastic Ma antigen family member 8C; paraneoplastic antigen-like protein 8C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:110806277)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A1B0GUJ8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B7ZBB8-1",
        "uniprot_id": [
            {
                "id": "PP13G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B7ZBB8",
                "type": "external"
            }
        ],
        "mass": 38019.0,
        "length": 358,
        "protein_name": "Protein phosphatase 1 regulatory subunit 3G",
        "gene_name": "PPP1R3G",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 3G",
        "refseq_ac": [
            {
                "id": "NP_001138587",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138587",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP1R3G",
        "gene_names_refseq": "PPP1R3G",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3G",
        "protein_names_refseq": "protein phosphatase 1 regulatory subunit 3G; protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibitor subunit 3G",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:648791)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11948623;24275569;30410026;31092671;31848261;34592886;34862394;35580925",
        "class_list": "",
        "function": "Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity)., [UniProtKB]; Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) correlates with poor prognosis and immune infiltration in lung adenocarcinoma., [RefSeq, PubMed]; RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding",
        "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex",
        "go_biological_process": "GO:0005979 regulation of glycogen biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "B7ZBB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86WI1-1",
        "uniprot_id": [
            {
                "id": "PKHL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86WI1",
                "type": "external"
            }
        ],
        "mass": 465734.0,
        "length": 4243,
        "protein_name": "Fibrocystin-L",
        "gene_name": "PKHD1L1",
        "organism": "Human",
        "refseq_name": "fibrocystin-L precursor",
        "refseq_ac": [
            {
                "id": "NP_803875",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803875",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKHD1L1",
        "gene_names_refseq": "DFNB124; PKHD1L1; PKHDL1",
        "protein_names_uniprotkb": "Fibrocystin-L; PKHD1-like protein 1; Polycystic kidney and hepatic disease 1-like protein 1",
        "protein_names_refseq": "PKHD1-like protein 1; fibrocystin-L precursor; fibrocystin-L; polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1; polycystic kidney and hepatic disease 1-like protein 1; polycystic kidney and hepatic disease-like 1",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); autosomal recessive nonsyndromic deafness 124 (Disease Ontology:DOID:0070676)",
        "pathway": " (hsa:93035)",
        "pathway_count": 1,
        "publication_count": 43,
        "publication_id_list": "11237011;12620974;20068231;23090970;24190977;24714562;24715725;25548167;25645385;25892735;26154972;26375851;27600516;28218747;28228285;28411811;28556638;28832583;29242379;29393594;29437277;29557506;29786170;29789417;30315122;30410026;30429286;31217245;31844290;32357974;32387766;32938616;32983136;33968037;34171305;34185709;35051231;35580925;36010968;37074911;37938771;38203530;38459354",
        "class_list": "",
        "function": "Component of hair-cell stereocilia coat. Required for normal hearing., [UniProtKB, UniProtKB]; High probability of detection of PKHD1L1*I/I had a Long-lived women and PKHD1L1*I/D genotype was a significant factor in providing of male longevity of the ethnically homogeneous group of Tatars from the Republic of Bashkortostan, Russia., [RefSeq, PubMed]; PKHD1L1, a gene involved in the stereocilia coat, causes autosomal recessive nonsyndromic hearing loss., [RefSeq, PubMed]; PKHDL1 may have a role in cellular immunity, [RefSeq, PubMed]; Systematic Multiomic Analysis of PKHD1L1 Gene Expression and Its Role as a Predicting Biomarker for Immune Cell Infiltration in Skin Cutaneous Melanoma and Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 7,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 146,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 2,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q567P2;Q9UF27",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016020 membrane;GO:0032426 stereocilium tip;GO:0060171 stereocilium membrane",
        "go_biological_process": "GO:0006955 immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q86WI1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BX97-1",
        "uniprot_id": [
            {
                "id": "PLVAP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BX97",
                "type": "external"
            }
        ],
        "mass": 50594.0,
        "length": 442,
        "protein_name": "Plasmalemma vesicle-associated protein",
        "gene_name": "PLVAP",
        "organism": "Human",
        "refseq_name": "plasmalemma vesicle-associated protein",
        "refseq_ac": [
            {
                "id": "NP_112600",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112600",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLVAP; FELS; PV1",
        "gene_names_refseq": "DIAR10; FELS; PLVAP; PV-1; PV1; gp68",
        "protein_names_uniprotkb": "Plasmalemma vesicle-associated protein; Fenestrated endothelial-linked structure protein; PV-1; Plasmalemma vesicle protein 1",
        "protein_names_refseq": "PV-1 protein; fenestrated endothelial-linked structure protein; fenestrated-endothelial linked structure protein; plasmalemma vesicle protein 1; plasmalemma vesicle-associated protein",
        "tax_id": 9606,
        "disease": "congenital diarrhea (Disease Ontology:DOID:0060774); diarrhea 10, protein-losing enteropathy type (MONDO:MONDO:0032586)",
        "pathway": " (hsa:83483)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;11401446;15155804;15971170;17074750;23090970;24190977;24715725;26207260;29485866;29557506;29661969;29789417;29875123;30429286;30459171;31154438;31848261;33346700;33936100;34079085;34280928;35051231;36781482;36884119;37074911;37938771",
        "class_list": "",
        "function": "Circulating PV-1 as a marker of celiac disease-associated liver injury., [RefSeq, PubMed]; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development., [UniProtKB, UniProtKB]; PLVAP protein expression correlated with microbial composition, clinicopathological features, and prognosis of patients with stomach adenocarcinoma., [RefSeq, PubMed]; PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms., [RefSeq, PubMed]; Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway., [RefSeq, PubMed]; Plasmalemmal Vesicle-Associated Protein Is Associated with Endothelial Cells Sprouting from the Peribiliary Capillary Plexus in Human Cirrhotic Liver., [RefSeq, PubMed]; The role of PLVAP in endothelial cells. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 34,
        "disease_count": 2,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86VP0;Q8N8Y0;Q8ND68;Q8TER8;Q9BZD5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome;GO:0005901 caveola",
        "go_biological_process": "GO:0000165 MAPK cascade;GO:0032502 developmental process;GO:0043114 regulation of vascular permeability;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0002693 positive regulation of cellular extravasation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q9BX97-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43692-1",
        "uniprot_id": [
            {
                "id": "PI15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43692",
                "type": "external"
            }
        ],
        "mass": 29065.0,
        "length": 258,
        "protein_name": "Peptidase inhibitor 15",
        "gene_name": "PI15",
        "organism": "Human",
        "refseq_name": "peptidase inhibitor 15 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001311332",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311332",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PI15; CRISP8; P25TI",
        "gene_names_refseq": "CRISP8; P24TI; P25TI; PI15",
        "protein_names_uniprotkb": "Peptidase inhibitor 15; 25 kDa trypsin inhibitor; CRISP-8; Cysteine-rich secretory protein 8; PI-15; SugarCrisp; p25TI",
        "protein_names_refseq": "25 kDa trypsin inhibitor; CRISP-8; PI-15; cysteine-rich secretory protein 8; peptidase inhibitor 15 preproprotein; protease inhibitor 15; sugarCrisp",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51050)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11287197;29900129;30638862;35051231;37217939;8882727;9473672",
        "class_list": "",
        "function": "Human serine peptidase inhibitor PI15 as a potential host factor involved in the regulation of CPAF activation. Silencing expression as well as over expression of PI15 affected normal development of Chlamydia. Publication Status: Online-Only, [RefSeq, PubMed]; PI15 as a novel marker for predicting the diagnosis and follow-up of cholangiocarcinoma patients., [RefSeq, PubMed]; Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68CY1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030414 peptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "O43692-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75051-1",
        "uniprot_id": [
            {
                "id": "PLXA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75051",
                "type": "external"
            }
        ],
        "mass": 211104.0,
        "length": 1894,
        "protein_name": "Plexin-A2",
        "gene_name": "PLXNA2",
        "organism": "Human",
        "refseq_name": "plexin-A2 precursor",
        "refseq_ac": [
            {
                "id": "NP_079455",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXNA2; KIAA0463; OCT; PLXN2; PRO235",
        "gene_names_refseq": "OCT; PLXN2; PLXNA2",
        "protein_names_uniprotkb": "Plexin-A2; Semaphorin receptor OCT",
        "protein_names_refseq": "plexin 2; plexin-A2 precursor; semaphorin receptor OCT; transmembrane protein OCT",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5362);  (R-HSA-399954);  (R-HSA-399955);  (R-HSA-399956);  (R-HSA-416700)",
        "pathway_count": 5,
        "publication_count": 69,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10075701;10520995;10559936;10648410;10679438;10934324;11114375;11276226;11278486;11604131;12093729;12372285;12422220;12882840;12975309;14685275;15218527;15550623;15652488;15676027;16286926;16431844;16715077;16930978;17318185;17607942;17607944;19159218;19664994;23186163;23584533;24190977;25518740;25645385;25892735;27600516;28832583;28834231;29091353;29242379;29393594;29557506;29769354;30192525;30429286;31154438;31530632;31844290;31848261;32157095;32350084;32387766;32502341;32938616;33141586;33592498;33749153;33968037;34327814;34357683;35051231;35251023;36010968;36658114;37074911;8570614;8955171",
        "class_list": "",
        "function": "Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)., [UniProtKB, PubMed]; Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques., [RefSeq, PubMed]; Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction., [RefSeq, PubMed]; PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder., [RefSeq, PubMed]; PLXNA2 as a candidate gene in patients with intellectual disability., [RefSeq, PubMed]; Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 75,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RTX9;B2RMX7;Q6UX61;Q96GN9;Q9BRL1;Q9UIW1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0017154 semaphorin receptor activity",
        "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0021915 neural tube development;GO:0030334 regulation of cell migration;GO:0001756 somitogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "O75051-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100010011001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O94827-5",
        "uniprot_id": [
            {
                "id": "PKHG5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O94827",
                "type": "external"
            }
        ],
        "mass": 111231.0,
        "length": 1006,
        "protein_name": "Pleckstrin homology domain-containing family G member 5",
        "gene_name": "PLEKHG5",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family G member 5 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001036129",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036129",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHG5; KIAA0720",
        "gene_names_refseq": "ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4; PLEKHG5; Syx; Tech",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 5; GEF720; Guanine nucleotide exchange factor 720; PH domain-containing family G member 5",
        "protein_names_refseq": "NFkB activating protein; PH domain-containing family G member 5; guanine nucleotide exchange factor 720; novel PH domain-containing protein; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5 isoform a; pleckstrin homology domain-containing family G member 5; synectin-binding guanine exchange factor",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease recessive intermediate C (Disease Ontology:DOID:0110198); autosomal recessive distal hereditary motor neuronopathy 4 (Disease Ontology:DOID:0111213)",
        "pathway": " (hsa:57449);  (R-HSA-193648);  (R-HSA-416482);  (R-HSA-8980692);  (R-HSA-9696264);  (R-HSA-9696273)",
        "pathway_count": 6,
        "publication_count": 208,
        "publication_id_list": "10037681;10232922;10490598;10523665;10523675;10526156;10579713;10619026;10664463;10699171;10873388;11058585;11085924;11207612;11283606;11294240;11313914;11373293;11396949;11431473;11432776;11606631;11672528;11680691;11689693;11704860;11742120;11756498;11784792;11804589;11804590;11884391;11912491;11940653;12071859;12093360;12097334;12101119;12123608;12195014;12221077;12221096;12433842;12515866;12531887;12650940;12761501;12842009;12857875;12877655;14512443;14673001;15023524;15064355;15107133;15302923;15342493;15470142;15485661;15601624;15611138;15699075;15738000;15749160;15850391;15866170;15951850;16112081;16116428;16184169;16212495;16217026;16467373;16519628;16630611;16776779;16777452;16777849;16862148;16896804;16914516;16923326;17077126;17562871;17564964;17702745;17765681;17804252;17932950;17942708;17976533;18158243;18218625;18374420;18577758;18829452;18996843;19103606;19212140;19494238;19605563;19635168;19673492;19713215;20030946;20101212;20400958;20591975;20628200;20660154;20811643;21148482;21351730;21454492;21565175;21699497;21865595;21936715;22096251;22298643;22305756;22661716;22673745;22911862;22992742;23200924;23255595;23434736;23572525;23777631;23844677;23870313;24086303;24128008;24259668;24335996;24352656;24690281;24933155;25211221;25414122;25704760;26371245;26529257;26887924;26969432;27072905;27145964;27216196;27481945;27986909;28112683;28196833;28584191;28847484;29146911;30007591;31105010;31309383;31871319;32203420;32938616;33220101;33318498;33968037;34509645;35051231;35251023;35639414;36010968;7479768;7673236;7721814;7753201;7937899;8021274;8537347;8543060;8571126;8617235;8643598;8649376;8649427;8662891;8756646;8769096;8807639;8810315;8816443;8939998;9013646;9111050;9113980;9305890;9308960;9418861;9490638;9497316;9520479;9531558;9535835;9548756;9659915;9670022;9792683;9796816;9822605;9829970",
        "class_list": "",
        "function": "Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma., [RefSeq, PubMed]; Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Also affects the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631)., [UniProtKB, PubMed, PubMed, UniProtKB]; Novel variants broaden the phenotypic spectrum of PLEKHG5-associated neuropathies., [RefSeq, PubMed]; PLEKHG5 promoted glioma cell migration and invasion.The expression patterns of PLEKHG5 are related to the glioma patients' survival., [RefSeq, PubMed]; PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KU07;B7Z2M3;B7Z5X2;F5GZ21;F5H1I0;Q5SY17;Q5T8W5;Q5T8W9;Q6ZNM0;Q7Z436;Q86YD8;Q96BS1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043542 endothelial cell migration;GO:0035767 endothelial cell chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 20.9,
        "record_id": "O94827-5",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C851-1",
        "uniprot_id": [
            {
                "id": "PIRT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C851",
                "type": "external"
            }
        ],
        "mass": 15334.0,
        "length": 137,
        "protein_name": "Phosphoinositide-interacting protein",
        "gene_name": "PIRT",
        "organism": "Human",
        "refseq_name": "phosphoinositide-interacting protein",
        "refseq_ac": [
            {
                "id": "NP_001094857",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094857",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIRT",
        "gene_names_refseq": "PIRT",
        "protein_names_uniprotkb": "Phosphoinositide-interacting protein",
        "protein_names_refseq": "phosphoinositide-interacting protein; phosphoinositide-interacting regulator of TRPV1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:644139)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "26992070;28832583;29242379;29724821;31575973;32983136",
        "class_list": "",
        "function": "Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity)., [UniProtKB]; These results have uncovered species-specific TRPM8 modulation by PIRT. They provide evidence for a direct interaction between PIRT and the TRPM8 S1-S4 domain with a 1:1 binding stoichiometry, suggesting that a functional tetrameric TRPM8 channel has four PIRT-binding sites., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z648",
        "ec_number_list": [],
        "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0044325 transmembrane transporter binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0051930 regulation of sensory perception of pain",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P0C851-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55058-1",
        "uniprot_id": [
            {
                "id": "PLTP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55058",
                "type": "external"
            }
        ],
        "mass": 54739.0,
        "length": 493,
        "protein_name": "Phospholipid transfer protein",
        "gene_name": "PLTP",
        "organism": "Human",
        "refseq_name": "phospholipid transfer protein isoform c precursor",
        "refseq_ac": [
            {
                "id": "NP_001229849",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229849",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLTP",
        "gene_names_refseq": "BPIFE; HDLCQ9; PLTP",
        "protein_names_uniprotkb": "Phospholipid transfer protein; Lipid transfer protein II",
        "protein_names_refseq": "BPI fold containing family E; lipid transfer protein II; phospholipid transfer protein isoform c precursor",
        "tax_id": 9606,
        "disease": "dry eye syndrome (Disease Ontology:DOID:10140); atherosclerosis (Disease Ontology:DOID:1936)",
        "pathway": " (hsa:5360)",
        "pathway_count": 1,
        "publication_count": 77,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10333293;11013307;11782012;12966036;16335952;18669648;19139490;19159218;19321130;21515415;21736953;23345538;23584533;23719902;23783831;24190977;25645385;25813380;26154972;26375851;26992070;27726376;27862975;27920218;28218747;28228285;28467828;28904123;29242379;29314611;29391424;29393594;29437277;29557506;29632046;29671580;29741879;29786170;29883800;30315122;30429286;30626607;31154438;31637018;31844290;31848261;31998317;32125861;32157095;32350084;32387766;32502341;32938616;33123756;33141586;33298915;33631671;33968037;34171305;34357683;34385888;35051231;35318648;35341274;35580925;36010968;36284347;36309086;36544145;37074911;37938771;7654777;8132678;9132017",
        "class_list": "",
        "function": "AGTR1, PLTP, and SCG2 associated with immune genes and immune cell infiltration in calcific aortic valve stenosis: analysis from integrated bioinformatics and machine learning., [RefSeq, PubMed]; Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations. Publication Status: Online-Only, [RefSeq, PubMed]; Exhaled phospholipid transfer protein and hepatocyte growth factor receptor in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Lipocalin-1 is the acceptor protein for phospholipid transfer protein in tears., [RefSeq, PubMed]; Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:11013307, PubMed:19321130, PubMed:21515415, PubMed:29883800, PubMed:7654777, PubMed:9132017). Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine (PubMed:9132017). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (PubMed:29883800). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (PubMed:21736953). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (PubMed:11013307)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis., [RefSeq, PubMed]; The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 78,
        "disease_count": 2,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K006;B4DDD5;B4DRB4;E1P5N8;E7EV16;Q8WTT1;Q9BR07;Q9BSH8",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity;GO:0008035 high-density lipoprotein particle binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:1901611 phosphatidylglycerol binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0034364 high-density lipoprotein particle",
        "go_biological_process": "GO:0046836 glycolipid transport;GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0010875 positive regulation of cholesterol efflux;GO:0035627 ceramide transport",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "P55058-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13401-1",
        "uniprot_id": [
            {
                "id": "PM2P3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13401",
                "type": "external"
            }
        ],
        "mass": 18716.0,
        "length": 168,
        "protein_name": "Putative postmeiotic segregation increased 2-like protein 3",
        "gene_name": "PMS2P3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PMS2P3; PMS2L3; PMS2L9; PMS5; PMSR3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative postmeiotic segregation increased 2-like protein 3; PMS2-related protein 3; Postmeiotic segregation increased 2-like protein 9; Postmeiotic segregation increased protein 5; Putative postmeiotic segregation increased 2 pseudogene 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 10,
        "publication_id_list": "26992070;28218747;28228285;29437277;30315122;30379171;30410026;31844290;33912179;8586419",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NG70;Q3MJ29",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016887 ATP hydrolysis activity;GO:0140664 ATP-dependent DNA damage sensor activity",
        "go_cellular_component": "GO:0032300 mismatch repair complex",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006298 mismatch repair",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q13401-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53GL0-1",
        "uniprot_id": [
            {
                "id": "PKHO1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53GL0",
                "type": "external"
            }
        ],
        "mass": 46237.0,
        "length": 409,
        "protein_name": "Pleckstrin homology domain-containing family O member 1",
        "gene_name": "PLEKHO1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family O member 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001291651",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291651",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHO1; CKIP1; HQ0024c; OC120",
        "gene_names_refseq": "CKIP-1; CKIP1; JBP; OC120; PLEKHO1",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 1; C-Jun-binding protein; CK2-interacting protein 1; CKIP-1; Casein kinase 2-interacting protein 1; JBP; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1",
        "protein_names_refseq": "C-Jun-binding protein; CK2 interacting protein 1; CK2-interacting protein 1; HQ0024c protein; PH domain-containing family O member 1; casein kinase 2-interacting protein 1; osteoclast maturation-associated gene 120 protein; pleckstrin homology domain-containing family O member 1 isoform b; pleckstrin homology domain-containing family O member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51177)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "10799509;11237011;11483580;11827170;14729969;15254037;15706351;15831458;16325375;16987810;17197158;17942896;19664994;24714562;25418920;25880248;26728094;27846572;27920218;28063628;28649982;28832583;29242379;29393594;29557506;29632046;30429286;31154438;31530632;31844290;31848261;31998317;32157095;32502341;32938616;32983136;33141586;33912179;33968037;34932366;35051231;35580925;36284347;36631036;37351817;37668684;37938771;39169452",
        "class_list": "",
        "function": "Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults., [RefSeq, PubMed]; CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy., [RefSeq, PubMed]; CKIP-1 is cleaved by caspase-3 during apoptosis. C-terminal fragments translocate to the cytoplasm and nucleus and inhibit AP-1 activity via direct interaction with c-Jun and JunD. CKIP-1 also forms a feedback with caspase-3 and enhances apoptosis., [RefSeq, PubMed]; CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein., [RefSeq, PubMed]; CKIP-1 silencing suppresses OSCC via mitochondrial homeostasis-associated TFAM/cGAS-STING signalling axis., [RefSeq, PubMed]; Examination of CK2alpha for a region that mediates interactions with CKIP-1 revealed a putative HIKE domain; this motif by itself may not be sufficient to mediate interactions., [RefSeq, PubMed]; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q336K5;Q8IZ51;Q9NRV3;Q9UL48",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0032587 ruffle membrane;GO:0036195 muscle cell projection membrane;GO:0016020 membrane",
        "go_biological_process": "GO:1901739 regulation of myoblast fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q53GL0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NEB5-1",
        "uniprot_id": [
            {
                "id": "PLPP5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NEB5",
                "type": "external"
            }
        ],
        "mass": 29484.0,
        "length": 264,
        "protein_name": "Phospholipid phosphatase 5",
        "gene_name": "PLPP5",
        "organism": "Human",
        "refseq_name": "phospholipid phosphatase 5 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001096029",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096029",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLPP5; DPPL1; HTPAP; PPAPDC1B",
        "gene_names_refseq": "DPPL1; HTPAP; PLPP5; PPAPDC1B",
        "protein_names_uniprotkb": "Phospholipid phosphatase 5; 3.1.3.4; 3.6.1.75; Phosphatidic acid phosphatase type 2 domain-containing protein 1B",
        "protein_names_refseq": "diacylglycerol pyrophosphate like 1; diacylglycerol pyrophosphate phosphatase-like 1; phosphatidate phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2 domain containing 1B; phosphatidic acid phosphatase type 2 domain-containing protein 1B; phospholipid phosphatase 5 isoform 1; testicular secretory protein Li 38",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84513);  (R-HSA-2029485)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10224668;10579907;11237011;11425868;11749377;12660731;12869549;15161916;15294978;15536084;15809313;16261160;16497229;16678913;17590538;18757432;21219541;21531764;23481700;24051013;24603412;24715725;26992070;27846572;27920218;28649982;28832583;28904123;29242379;29393594;29493099;29557506;30315122;30484775;31217245;31844290;32161166;32350084;32488085;32938616;33691108;33717175;34171305;35051231;35580925;36284347;7517665;8228618;8657103;9973503",
        "class_list": "",
        "function": "DPPL1 and DPPL2 represent a novel type of mammalian phosphatidate phosphatase., [RefSeq, PubMed]; Findings identify an HTPAP genotype and associated gene expression pattern that favors metastasis progression and that could be used to predict tumor metastasis and prognosis in HCC patients. Erratum:[Cancer Res. 2011 Jun 15;71(12):4325], [RefSeq, PubMed]; Genetic variants at loci -1053 and +64 of the HTPAP promoter affect the expression of HTPAP, which might be a novel determinant and target for HCC prognosis Publication Status: Online-Only, [RefSeq, PubMed]; HTPAP is a novel metastatic suppressor gene for hepatocellular carcinoma, [RefSeq, PubMed]; HTPAP-1 may be the transcript of HTPAP to exhibit a suppressive role on hepatocellular cancer(HCC) metastasis, and can be a prognostic marker for HCC., [RefSeq, PubMed]; Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538)., [UniProtKB, PubMed]; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules., [UniProtKB, UniProtKB, UniProtKB]; Microarray experiments on PPAPDC1B knockdown indicated this gene interfered with cell signaling pathways, including Janus-activated kinase-signal transducer and activator of transcription, mitogen-activated protein kinase, and protein kinase C pathways, [RefSeq, PubMed]; PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JKF5;Q3KQX6;Q9BY45",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4",
                "type": "external"
            },
            {
                "id": "3.1.3.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106",
                "type": "external"
            },
            {
                "id": "3.6.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
                "type": "external"
            },
            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q8NEB5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NFJ6-1",
        "uniprot_id": [
            {
                "id": "PKR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NFJ6",
                "type": "external"
            }
        ],
        "mass": 43996.0,
        "length": 384,
        "protein_name": "Prokineticin receptor 2",
        "gene_name": "PROKR2",
        "organism": "Human",
        "refseq_name": "prokineticin receptor 2",
        "refseq_ac": [
            {
                "id": "NP_658986",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_658986",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROKR2; GPR73L1; PKR2",
        "gene_names_refseq": "GPR73L1; GPR73b; GPRg2; HH3; KAL3; PKR2; PROKR2; dJ680N4.3",
        "protein_names_uniprotkb": "Prokineticin receptor 2; G protein-coupled receptor 73-like 1; G protein-coupled receptor I5E; GPR73b; GPRg2; PK-R2",
        "protein_names_refseq": "G protein-coupled receptor 73-like 1; G-protein coupled receptor I5E; PK-R2; prokineticin receptor 2",
        "tax_id": 9606,
        "disease": "hypogonadotropic hypogonadism 3 with or without anosmia (Disease Ontology:DOID:0090092)",
        "pathway": " (hsa:128674);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 133,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11237011;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;11886876;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15126578;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;17054399;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18559922;18577758;18826963;18936096;1905813;21161321;22927827;23446738;23643382;23690594;24906252;25077900;2649896;27496565;2841328;28858133;3086311;3202875;3366244;3525564;35922219;36694982;37188888;37338295;38272512;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism., [RefSeq, PubMed]; Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular cloning, amino acid sequence and expression in several human tissues, [RefSeq, PubMed]; PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency., [RefSeq, PubMed]; Paracrine role for the PKs and their receptors in endometrial vascular function., [RefSeq, PubMed]; Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease., [RefSeq, PubMed]; Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]., [RefSeq]; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase., [UniProtKB]; [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism]., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5JUU1;Q2M3C0;Q5TDY1;Q9NTT0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "Q8NFJ6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHP8-1",
        "uniprot_id": [
            {
                "id": "PLBL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHP8",
                "type": "external"
            }
        ],
        "mass": 65472.0,
        "length": 589,
        "protein_name": "Putative aminopeptidase PLBD2",
        "gene_name": "PLBD2",
        "organism": "Human",
        "refseq_name": "putative aminopeptidase PLBD2 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001153199",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153199",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLBD2",
        "gene_names_refseq": "P76; PLBD2; PLBL2",
        "protein_names_uniprotkb": "Putative aminopeptidase PLBD2; 3.4.11.-; 76 kDa protein; LAMA-like protein 2; Lamina ancestor homolog 2; Phospholipase B domain-containing protein 2; p76",
        "protein_names_refseq": "76 kDa protein; LAMA-like protein 2; PLB homolog 2; lamina ancestor homolog 2; mannose-6-phosphate protein associated protein p76; phospholipase B domain-containing protein 2; phospholipase B-like 2 32 kDa form; phospholipase B-like 2 45 kDa form; putative aminopeptidase PLBD2 isoform 2 precursor; putative aminopeptidase PLBD2; putative phospholipase B-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196463)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;11237011;17105447;19159218;19413330;22424782;23090970;23481700;24190977;24715725;25418920;25502872;25645385;26992070;27600516;27846572;28063628;28218747;28228285;28467828;28657654;28832583;28834231;28855257;29242379;29437277;29493099;29557506;29632046;29741879;29786170;30315122;30410026;30429286;30573663;31020640;31217245;31530632;31844290;31848261;31998317;32161166;32350084;32357974;32387766;32897882;32938616;32983136;33123756;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34019948;34089345;34357683;34405274;34725712;35051231;35154160;35251023;35289036;35580925;36010968;36215666;36241641;36284347;37074911;37340703;37541260;38665916;39531497;40596516",
        "class_list": "",
        "function": "Describe the identification of p76 by MS and we analyze several of its biochemical characteristics, [RefSeq, PubMed]; Putative aminopeptidase., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 22,
        "disease_count": 0,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H5E2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004620 phospholipase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0070062 extracellular exosome;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "Q8NHP8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TD55-1",
        "uniprot_id": [
            {
                "id": "PKHO2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TD55",
                "type": "external"
            }
        ],
        "mass": 53350.0,
        "length": 490,
        "protein_name": "Pleckstrin homology domain-containing family O member 2",
        "gene_name": "PLEKHO2",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family O member 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001181988",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181988",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHO2; PLEKHQ1; PP9099",
        "gene_names_refseq": "PLEKHO2; PLEKHQ1; PP1628; pp9099",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 2; PH domain-containing family O member 2; PH domain-containing family Q member 1; Pleckstrin homology domain-containing family Q member 1",
        "protein_names_refseq": "PH domain-containing family O member 2; PH domain-containing family Q member 1; PH domain-containing protein; pleckstrin homology domain-containing family O member 2 isoform 2; pleckstrin homology domain-containing family O member 2; pleckstrin homology domain-containing family Q member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80301);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "15498874;17525332;19664995;20058876;23186163;23650620;24275569;25576301;27846572;27862975;28832583;28904123;29351928;29393594;29557506;29632046;29786170;30429286;31844290;32387766;32938616;33123756;33592498;33968037;33981976;34070923;34171305;35051231;35580925;38665916;40914422;8692836",
        "class_list": "",
        "function": "The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7L4H4;Q8WYS8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:1904813 ficolin-1-rich granule lumen",
        "go_biological_process": "GO:0071888 macrophage apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q8TD55-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WY50-1",
        "uniprot_id": [
            {
                "id": "PLAC4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WY50",
                "type": "external"
            }
        ],
        "mass": 16680.0,
        "length": 150,
        "protein_name": "Placenta-specific protein 4",
        "gene_name": "PLAC4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PLAC4; C21orf115; D21S418E; PP1416",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Placenta-specific protein 4",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "15498874;23481700;33592498;36010968;36215666;8406465",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8WY50-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0CW24-1",
        "uniprot_id": [
            {
                "id": "PNM6A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0CW24",
                "type": "external"
            }
        ],
        "mass": 43875.0,
        "length": 399,
        "protein_name": "Paraneoplastic antigen-like protein 6A",
        "gene_name": "PNMA6A",
        "organism": "Human",
        "refseq_name": "paraneoplastic antigen-like protein 6A",
        "refseq_ac": [
            {
                "id": "NP_116271",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116271",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNMA6A; PNMA6C",
        "gene_names_refseq": "MA6; PNMA6A; PNMA6C; PNMA6",
        "protein_names_uniprotkb": "Paraneoplastic antigen-like protein 6A",
        "protein_names_refseq": "paraneoplastic Ma antigen family member 6A; paraneoplastic Ma antigen family member 6C; paraneoplastic antigen-like 6A related protein; paraneoplastic antigen-like protein 6A; paraneoplastic antigen-like protein 6C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84968)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "19366867;29557506;30379171;30429286;32157095",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1G4;D3DWT8;P0CW26;Q96A40",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "P0CW24-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HBJ0-1",
        "uniprot_id": [
            {
                "id": "PLAC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HBJ0",
                "type": "external"
            }
        ],
        "mass": 23616.0,
        "length": 212,
        "protein_name": "Placenta-specific protein 1",
        "gene_name": "PLAC1",
        "organism": "Human",
        "refseq_name": "placenta-specific protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001303816",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303816",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAC1",
        "gene_names_refseq": "CT92; OOSP2B; OOSP2L; PLAC1",
        "protein_names_uniprotkb": "Placenta-specific protein 1",
        "protein_names_refseq": "cancer/testis antigen 92; placenta specific 1; placenta-specific protein 1 precursor; placenta-specific protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10761)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "10995572;12412044;15608456;15803460;16594548;27893789;29556312;31217245;33968037;34118612;34523695;34565269;36835024;37568074",
        "class_list": "",
        "function": "Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value. Publication Status: Online-Only, [RefSeq, PubMed]; MRNA transcripts from placenta-expressed specific gene are detectable in maternal blood and rapidly disappear after delivery, [RefSeq, PubMed]; May play a role in placental development., [UniProtKB, PubMed]; PLAC1 affects cell to cell communication by interacting with the desmosome complex., [RefSeq, PubMed]; PLAC1 expression is upregulated during trophoblast differentiation, localizing primarily to the differentiated syncytiotrophoblast., [RefSeq, PubMed]; PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer., [RefSeq, PubMed]; PLAC1, a trophoblast-specific gene, is Trophoblast-specific expression throughout gestation and responsiveness to KGF are consistent with a fundamental role for PLAC1 at the maternal-fetal interface., [RefSeq, PubMed]; Placenta-specific protein 1 (PLAC1) expression is significantly down-regulated in preeclampsia via a hypoxia-mediated mechanism., [RefSeq, PubMed]; Plasma PLAC1 and glial cells-missing 1 mRNAs appear promising as noninvasively measurable molecular markers for pre-eclampsia, [RefSeq, PubMed]; The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved? Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0001890 placenta development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q9HBJ0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NTG1-1",
        "uniprot_id": [
            {
                "id": "PKDRE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NTG1",
                "type": "external"
            }
        ],
        "mass": 255449.0,
        "length": 2253,
        "protein_name": "Polycystin family receptor for egg jelly",
        "gene_name": "PKDREJ",
        "organism": "Human",
        "refseq_name": "polycystin family receptor for egg jelly precursor",
        "refseq_ac": [
            {
                "id": "NP_006062",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006062",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKDREJ",
        "gene_names_refseq": "PKDREJ",
        "protein_names_uniprotkb": "Polycystin family receptor for egg jelly; PKD and REJ homolog; Polycystic kidney disease and receptor for egg jelly-related protein",
        "protein_names_refseq": "PKD and REJ homolog; polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin); polycystic kidney disease and receptor for egg jelly-related protein; polycystin (PKD) family receptor for egg jelly; polycystin family receptor for egg jelly precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10343)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "16959974;18991276;25418920;25892735;26811146;29557506;31429579;32387766;32938616;33392160;34509645;35051231;35580925;9949214",
        "class_list": "",
        "function": "Testis-specific protein that controls sperm transport and the timing of zona pellucida-evoked exocytosis of the sperm acrosome., [UniProtKB, UniProtKB]; This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 18,
        "predicted_n_glycosites": 17,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 91,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 18,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AJY3;O95850",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0002080 acrosomal membrane",
        "go_biological_process": "GO:0007340 acrosome reaction;GO:0050982 detection of mechanical stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q9NTG1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TCW9-1",
        "uniprot_id": [
            {
                "id": "PKR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TCW9",
                "type": "external"
            }
        ],
        "mass": 44770.0,
        "length": 393,
        "protein_name": "Prokineticin receptor 1",
        "gene_name": "PROKR1",
        "organism": "Human",
        "refseq_name": "prokineticin receptor 1",
        "refseq_ac": [
            {
                "id": "NP_620414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROKR1; GPR73; PKR1",
        "gene_names_refseq": "GPR73a; GPR73; PK-R1; PKR1; PROKR1; ZAQ",
        "protein_names_uniprotkb": "Prokineticin receptor 1; G protein-coupled receptor 73; G protein-coupled receptor ZAQ; GPR73a; PK-R1",
        "protein_names_refseq": "G protein-coupled receptor 73; G protein-coupled receptor ZAQ; prokineticin receptor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10887);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 128,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;11886876;12054613;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15126578;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18339712;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23690594;24715725;24906252;2649896;27496565;2841328;29557506;3086311;31304922;3202875;32350084;32585394;33184929;3366244;33811988;3525564;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Molecular cloning, amino acid sequence and expression in several human tissues, [RefSeq, PubMed]; PROK-1 and its receptors are involved in the pathogenesis and development of endometriosis, [RefSeq, PubMed]; Paracrine role for the PKs and their receptors in endometrial vascular function., [RefSeq, PubMed]; Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle., [RefSeq, PubMed]; Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2., [RefSeq, PubMed]; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy., [UniProtKB, PubMed]; The role of prokineticins in recurrent implantation failure., [RefSeq, PubMed]; This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5JUU2;Q53QT9;Q8NFJ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q8TCW9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1A4S6-1",
        "uniprot_id": [
            {
                "id": "RHG10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A1A4S6",
                "type": "external"
            }
        ],
        "mass": 89375.0,
        "length": 786,
        "protein_name": "Rho GTPase-activating protein 10",
        "gene_name": "ARHGAP10",
        "organism": "Human",
        "refseq_name": "rho GTPase-activating protein 10",
        "refseq_ac": [
            {
                "id": "NP_078881",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078881",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ARHGAP10; GRAF2",
        "gene_names_refseq": "ARHGAP10; GRAF2; PS-GAP; PSGAP",
        "protein_names_uniprotkb": "Rho GTPase-activating protein 10; GRAF2; GTPase regulator associated with focal adhesion kinase 2; Graf-related protein 2; Rho-type GTPase-activating protein 10",
        "protein_names_refseq": "GTPase regulator associated with focal adhesion kinase 2; graf-related protein 2; rho GTPase-activating protein 10; rho-type GTPase-activating protein 10",
        "tax_id": 9606,
        "disease": "Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311)",
        "pathway": " (hsa:79658);  (R-HSA-211728);  (R-HSA-8980692);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 5,
        "publication_count": 363,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10619026;10699171;10699464;10724160;10873388;10873802;10958683;11007481;11058585;11085924;11149925;11207612;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12172552;12195014;12221077;12221096;12351724;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15471851;15485661;15507211;15579468;15601624;15611138;15728722;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16467373;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16968698;17064668;17077126;17145773;17196961;17214551;17244649;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18218625;18249095;18347018;18363964;18396277;18426980;18653540;18786931;18829452;18835169;18838382;18929667;19269969;19494238;19605563;19635168;19673492;19713215;19911011;19934221;20030946;20101212;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21148482;21351730;21454492;21542010;21565175;21613211;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22424782;22461490;22475431;22571869;22608513;22673745;22734669;22911862;22970203;22992742;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24259668;24335996;24352656;24366607;24584464;24715725;24859002;24933155;24960694;24996924;25024229;25211221;25428919;25576301;25704760;25721503;25795300;25862245;25892735;25963737;26129894;26154972;26299518;26371245;26375851;26529257;26598554;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27846572;27862975;27986909;28028151;28112683;28114311;28196833;28218747;28228285;28584191;28649982;28825699;28832583;28860633;28904123;29089502;29146911;29242379;29331515;29358323;29382922;29437277;29493099;29508533;29557506;29769354;29786170;30061681;30315122;30410026;30853411;31105010;31789419;31844290;31871319;32157095;32203420;32344433;32350084;32357974;32387766;32502341;32699248;32938616;32983136;33141586;33298915;33592498;33633747;33912179;33968037;33981976;34087483;34171305;34185709;34211107;34509645;34932366;35051231;35154160;35580925;36010968;36241641;36581221;37938771;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9792683;9822598;9822605;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Publication Status: Online-Only, [RefSeq, PubMed]; GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508., [RefSeq, PubMed]; GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433)., [UniProtKB, PubMed, UniProtKB, PubMed]; MiR3373p inhibits gastric tumor metastasis by targeting ARHGAP10., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PS-GAP is a novel regulator of caspase-activated PAK-2, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L0S5;Q2VPC4;Q2VPC5;Q96EV3;Q96S75",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007010 cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 36.4,
        "record_id": "A1A4S6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96R05-1",
        "uniprot_id": [
            {
                "id": "RET7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96R05",
                "type": "external"
            }
        ],
        "mass": 15536.0,
        "length": 134,
        "protein_name": "Retinoid-binding protein 7",
        "gene_name": "RBP7",
        "organism": "Human",
        "refseq_name": "retinoid-binding protein 7",
        "refseq_ac": [
            {
                "id": "NP_443192",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443192",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBP7",
        "gene_names_refseq": "CRABP4; CRBP4; CRBPIV; RBP7",
        "protein_names_uniprotkb": "Retinoid-binding protein 7; CRABP-IV; CRABP4; CRBP4; Cellular retinoic acid-binding protein 4; Cellular retinoic acid-binding protein IV",
        "protein_names_refseq": "cellular retinoic acid-binding protein 4; cellular retinoic acid-binding protein IV; cellular retinol binding protein 7; putative cellular retinol-binding protein CRBP IV; retinoid-binding protein 7; retinol binding protein 7, cellular",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116362)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;12177003;29557506;29786170;30379171;30429286;31154438;32938616;32983136;35051231;35580925;36537604;37664915;37938771",
        "class_list": "",
        "function": "Human CRBP IV belongs to a clearly distinct CRBP subfamily and suggest a relatively different mode of retinol binding for this binding protein., [RefSeq, PubMed]; Intracellular transport of retinol., [UniProtKB, PubMed]; RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma., [RefSeq, PubMed]; Reduced Expression of RBP7 is Associated with Resistance to Tamoxifen In Luminal A Breast Cancer., [RefSeq, PubMed]; The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R517;Q5SWJ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0015908 fatty acid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q96R05-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16540-1",
        "uniprot_id": [
            {
                "id": "RM23_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16540",
                "type": "external"
            }
        ],
        "mass": 17781.0,
        "length": 153,
        "protein_name": "Large ribosomal subunit protein uL23m",
        "gene_name": "MRPL23",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL23m isoform 1",
        "refseq_ac": [
            {
                "id": "NP_066957",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066957",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MRPL23; L23MRP; RPL23L",
        "gene_names_refseq": "L23MRP; L23mt; MRP-L23; MRPL23; RPL23L; uL23m",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL23m; 39S ribosomal protein L23, mitochondrial; L23 mitochondrial-related protein; L23mt; MRP-L23; Ribosomal protein L23-like",
        "protein_names_refseq": "39S ribosomal protein L23, mitochondrial; L23 mitochondrial-related protein; large ribosomal subunit protein uL23m isoform 1; mitochondrial large ribosomal subunit protein uL23m; ribosomal protein related to L23 (mitochondrial)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6150);  (R-HSA-5368286);  (R-HSA-5389840);  (R-HSA-5419276);  (R-HSA-9937383)",
        "pathway_count": 5,
        "publication_count": 44,
        "publication_id_list": "11237011;11543634;15358359;17803939;18429816;18782833;19524667;19716793;20186120;21907147;22172991;2250005;23481700;25233460;25278503;25418920;25838379;26154972;26992070;27029019;27920218;28218747;28510447;28832583;28892042;28904123;29242379;29437277;30315122;31217245;31844290;32157095;33141586;33243891;33298915;33592498;33878294;34357683;35177605;36010968;36302763;36596788;37141370;8541832",
        "class_list": "",
        "function": "Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MT29;Q96Q71",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044391 ribosomal subunit",
        "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q16540-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99584-1",
        "uniprot_id": [
            {
                "id": "S10AD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99584",
                "type": "external"
            }
        ],
        "mass": 11471.0,
        "length": 98,
        "protein_name": "Protein S100-A13",
        "gene_name": "S100A13",
        "organism": "Human",
        "refseq_name": "protein S100-A13",
        "refseq_ac": [
            {
                "id": "NP_001019381",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019381",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S100A13",
        "gene_names_refseq": "S100A13",
        "protein_names_uniprotkb": "Protein S100-A13; S100 calcium-binding protein A13",
        "protein_names_refseq": "protein S100-A13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6284)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "12746488;16145699;17374362;18259052;19284995;20068231;20863990;21270123;25576301;27846572;28904123;29093164;29393594;29557506;29786170;30379171;30429286;30524438;30670674;30779550;30833945;31073086;31154438;31530632;31844290;31848261;32157095;32265295;32350084;32357974;32493412;32502341;32897882;32938616;33043033;33298915;33592498;33691108;33968037;33981976;34087483;34171305;35051231;35251023;35318648;35580925;36010968;36241641;36284347;8878558",
        "class_list": "",
        "function": "An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (>/= 30 years) type 2 diabetes without diabetic retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; These findings unveil a critical role of the non-classical secretory pathway of IL-1alpha in cellular senescence and SASP regulation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52PI9;Q6FGF8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0015031 protein transport;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043303 mast cell degranulation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q99584-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0PJX4-1",
        "uniprot_id": [
            {
                "id": "SHSA3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0PJX4",
                "type": "external"
            }
        ],
        "mass": 25832.0,
        "length": 238,
        "protein_name": "Protein shisa-3 homolog",
        "gene_name": "SHISA3",
        "organism": "Human",
        "refseq_name": "protein shisa-3 homolog precursor",
        "refseq_ac": [
            {
                "id": "NP_001073974",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SHISA3",
        "gene_names_refseq": "SHISA3; hShisa3",
        "protein_names_uniprotkb": "Protein shisa-3 homolog",
        "protein_names_refseq": "protein shisa-3 homolog precursor; protein shisa-3 homolog; shisa homolog 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:152573)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "25968618;27846572;27920218;28299336;30573520;31801598;32488085;32692756",
        "class_list": "",
        "function": "Down-regulation of SHISA3 expression was associated with colorectal cancer., [RefSeq, PubMed]; For TKI-resistant PC9/ER tumors in nod-scid mice, overexpressed shisa3 had a significant inhibitory effect. In addition, we verified that shisa3 inhibited EGFR-TKI resistance by interacting with FGFR1/3 to regulate AKT/mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Low Shisa3 expression is associated with Nasopharyngeal Carcinoma Metastasis., [RefSeq, PubMed]; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling., [UniProtKB]; SHISA3 promoter hypermethylation might increase the risk of LSCC through regulation of gene expression and is a potential diagnostic and prognostic biomarker for laryngeal squamous cell carcinoma, [RefSeq, PubMed]; SHISA3, an antagonist of the Wnt/beta-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJX3;Q96EQ5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A0PJX4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRG4-1",
        "uniprot_id": [
            {
                "id": "SMYD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRG4",
                "type": "external"
            }
        ],
        "mass": 49688.0,
        "length": 433,
        "protein_name": "N-lysine methyltransferase SMYD2",
        "gene_name": "SMYD2",
        "organism": "Human",
        "refseq_name": "N-lysine methyltransferase SMYD2",
        "refseq_ac": [
            {
                "id": "NP_064582",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064582",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SMYD2; KMT3C",
        "gene_names_refseq": "HSKM-B; KMT3C; SMYD2; ZMYND14",
        "protein_names_uniprotkb": "N-lysine methyltransferase SMYD2; 2.1.1.-; 2.1.1.354; HSKM-B; Histone methyltransferase SMYD2; Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2",
        "protein_names_refseq": "N-lysine methyltransferase SMYD2; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N-methyltransferase 3C; zinc finger, MYND domain containing 14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56950);  (R-HSA-3214841);  (R-HSA-6804760)",
        "pathway_count": 3,
        "publication_count": 78,
        "publication_id_list": "10518217;10949293;11237011;11511361;11959841;12123582;12130538;12453418;12540855;12670868;14536086;14690610;14992727;15145825;15235609;15448695;15525938;15964846;16118227;16199523;16292313;16415881;16519522;16682010;16805913;17021013;17108971;17170761;17242690;17500065;17544230;17707229;17707234;17805299;18065756;18172012;18833288;19011621;19808676;20118233;20870719;20870725;21131967;21196496;21625555;21724641;21779408;21782458;21832073;21880715;22099308;22362889;22939622;23186163;25880248;28904123;30379171;31217245;31530632;31844290;31848261;32157095;32357974;32938616;33298915;33537174;33717175;33912179;33968037;34433824;35580925;36010968;36284347;37812330;38243079;38721826;38740816;39109795",
        "class_list": "",
        "function": "H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3., [RefSeq, PubMed]; Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide., [RefSeq, PubMed]; Methylation of ESCRT-III components regulates the timing of cytokinetic abscission. Publication Status: Online-Only, [RefSeq, PubMed]; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]., [RefSeq]; SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma Cells by Upregulating EVI2A., [RefSeq, PubMed]; SMYD2 induced PGC1alpha methylation promotes stemness maintenance of glioblastoma stem cells., [RefSeq, PubMed]; The combination of the SMYD2 interactome with the gene expression data suggests that some of the genes regulated by SMYD2 are closely associated with SMYD2-interacting proteins., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9P9;I6L9H7;Q4V765;Q5VSH9;Q96AI4",
        "ec_number_list": [
            {
                "id": "2.1.1.357",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.354",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.361",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361",
                "type": "external"
            },
            {
                "id": "2.1.1.355",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355",
                "type": "external"
            },
            {
                "id": "2.1.1.362",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362",
                "type": "external"
            },
            {
                "id": "2.1.1.367",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016278 lysine N-methyltransferase activity;GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0002039 p53 binding;GO:0046975 histone H3K36 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q9NRG4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P15153-1",
        "uniprot_id": [
            {
                "id": "RAC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P15153",
                "type": "external"
            }
        ],
        "mass": 21429.0,
        "length": 192,
        "protein_name": "Ras-related C3 botulinum toxin substrate 2",
        "gene_name": "RAC2",
        "organism": "Human",
        "refseq_name": "ras-related C3 botulinum toxin substrate 2",
        "refseq_ac": [
            {
                "id": "NP_002863",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002863",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAC2",
        "gene_names_refseq": "EN-7; Gx; HSPC022; IMD73A; IMD73B; IMD73C; RAC2; p21-Rac2",
        "protein_names_uniprotkb": "Ras-related C3 botulinum toxin substrate 2; 3.6.5.2; GX; Small G protein; p21-Rac2",
        "protein_names_refseq": "Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); ras-related C3 botulinum toxin substrate 2; small G protein",
        "tax_id": 9606,
        "disease": "autosomal dominant intellectual developmental disorder 48 (Disease Ontology:DOID:0080235); immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia (Disease Ontology:DOID:0112061); immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia (Disease Ontology:DOID:0112062); immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis (Disease Ontology:DOID:0112064); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:5880);  (R-HSA-114604);  (R-HSA-1222556);  (R-HSA-1257604);  (R-HSA-2219530);  (R-HSA-4086400);  (R-HSA-5668599);  (R-HSA-6811558);  (R-HSA-9013404)",
        "pathway_count": 9,
        "publication_count": 293,
        "publication_id_list": "10026222;10029572;10072071;10191262;10400704;10455184;10469124;10559471;10655614;10698942;10758162;10847683;10862746;11090627;11101902;11145705;11147812;11149925;11237011;11237855;11262396;11358862;11481033;11704860;11751577;11779461;11803464;11919634;11970843;12015986;12056906;12134165;12167717;12533515;12716910;12767043;12813055;12832405;12839624;1316893;1325671;14530365;14636582;1464587;14675773;15023524;15143170;15169870;15169958;15501440;15542837;15591124;15608632;15642721;15708849;15718470;15814684;15824103;15834429;15936275;16081809;16116452;16174766;16243035;16243036;16280981;16329988;16339315;16456541;16495441;16507994;1660188;16602827;16636067;16647110;16723543;16762923;16777452;16778989;16938345;16959974;16971168;17021034;17060455;17130287;17158234;17200115;17214551;17269730;17373907;17433286;17583407;17616532;17626883;17627283;17662945;17698854;17765681;18056264;18079394;18162551;18191593;18215320;18256687;18317450;18347018;18477386;18589439;18594509;18606717;18662984;18719708;1874735;18754654;18755892;18798527;18829560;18925875;18955485;1902092;19028840;1903399;19089323;19185485;19365405;19372727;19394299;19409513;19411071;19523939;19530173;19576174;19589360;19608861;19644473;19700402;19805105;19850008;19962665;20004982;20006983;20134026;20231295;20338997;20522708;20713702;20803696;20813901;20940229;20956805;21124855;21151158;21188471;21239714;21316585;21317208;21368164;21378159;21478295;21668414;21827948;21976531;21984976;22120714;22188813;22267732;22588880;22773843;22802530;22808130;23109420;23140633;23144463;23255595;23289851;23396967;23481700;23757206;23821037;23870057;23875749;23980663;24141704;24623723;24714562;25469497;25505266;25512081;25576301;25810538;25862245;25877926;26016997;26154972;26375851;26728094;2674130;26929215;26992070;27397612;27452731;27481945;27543614;27558335;27846572;27862975;27920218;28218747;28228285;2825632;2841328;2848506;28736554;28832583;28834231;28904123;29242379;29351928;29493099;29557506;29632046;29632711;29786170;30315122;30524438;30654050;30723080;31071452;31154438;31382036;31389670;31530632;31844290;31848261;31871319;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33298915;33592498;33717175;33936100;33968037;34078123;34171305;34357683;34509645;34561969;34932366;35051231;35132862;35318648;35580925;35705054;36010968;36241641;36284347;38194689;40307207;40596516;7479768;7624799;7637810;7744773;7980580;8089108;8246984;8504089;8537108;8617742;8645157;8657148;8673706;8986718;8990121;9028946;9113980;9438848;9674432;9705280;9716412;9736715;9768361;9804763;9895304",
        "class_list": "",
        "function": "Clinical and functional spectrum of RAC2-related immunodeficiency. Erratum:[Blood. 2024 Sep 5;144(10):1132. doi: 10.1182/blood.2024025827. PMID: 39235795], [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). Activates PLCG2 (PubMed:19394299)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UDJ4",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.1.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "1.6.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "3.2.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "1.3.1.70",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0019887 protein kinase regulator activity;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005635 nuclear envelope;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:1903955 positive regulation of protein targeting to mitochondrion",
        "synthesized_glycan_count": 0,
        "hit_score": 29.9,
        "record_id": "P15153-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60240-1",
        "uniprot_id": [
            {
                "id": "PLIN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60240",
                "type": "external"
            }
        ],
        "mass": 55990.0,
        "length": 522,
        "protein_name": "Perilipin-1",
        "gene_name": "PLIN1",
        "organism": "Human",
        "refseq_name": "perilipin-1",
        "refseq_ac": [
            {
                "id": "NP_001138783",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138783",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLIN1; PERI; PLIN",
        "gene_names_refseq": "FPLD4; PERI; PLIN1; PLIN",
        "protein_names_uniprotkb": "Perilipin-1; Lipid droplet-associated protein",
        "protein_names_refseq": "lipid droplet-associated protein; perilipin-1",
        "tax_id": 9606,
        "disease": "familial partial lipodystrophy type 4 (Disease Ontology:DOID:0070205); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:5346);  (R-HSA-163560);  (R-HSA-381340);  (R-HSA-9031528);  (R-HSA-9841922)",
        "pathway_count": 5,
        "publication_count": 71,
        "publication_id_list": "10075656;10425206;10558993;10671541;10835357;10882139;11027271;11095972;11237011;11751901;11872672;12213831;12802495;12829629;12832420;1310260;15273253;15364929;15456755;15850785;15919796;16380219;16741517;17011499;17603008;17761950;17980149;18931025;19043829;19115207;19172745;19181555;20101261;21030586;21345103;21504868;23239344;23399566;24275569;24715725;26357594;27832861;29351928;29557506;29688805;30811273;31154438;31844290;31848261;31924761;33329381;35051231;35771980;37368137;37843309;38214891;38453058;39215210;8325954;8521497;8521498;8643605;8706692;8770873;8970730;9065481;9171241;9454824;9521880;9744270;9836620",
        "class_list": "",
        "function": "Clinical pathological significance and biological function of PLIN1 in hepatocellular carcinoma: bioinformatics analysis and in vitro experiments. Publication Status: Online-Only, [RefSeq, PubMed]; Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds., [RefSeq, PubMed]; Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression., [RefSeq, PubMed]; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels., [UniProtKB, PubMed]; Perilipin 1: a systematic review on its functions on lipid metabolism and atherosclerosis in mice and humans., [RefSeq, PubMed]; Perilipin could be a factor behind impaired lipolysis in insulin-resistants sconditions., [RefSeq, PubMed]; RS2289487 variation in PERILIPIN gene is a predictor of weight loss and protection against impaired glucose metabolism after a meal-replacement diet in postmenopausal obese females., [RefSeq, PubMed]; The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N5Y6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding;GO:0140311 protein sequestering activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process;GO:0010897 negative regulation of triglyceride catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "O60240-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0J9YXQ4-1",
        "uniprot_id": [
            {
                "id": "PMA6E_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0J9YXQ4",
                "type": "external"
            }
        ],
        "mass": 65155.0,
        "length": 647,
        "protein_name": "Paraneoplastic antigen Ma6E",
        "gene_name": "PNMA6E",
        "organism": "Human",
        "refseq_name": "paraneoplastic antigen Ma6E isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001354699",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001354699",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNMA6E",
        "gene_names_refseq": "PNMA6E",
        "protein_names_uniprotkb": "Paraneoplastic antigen Ma6E",
        "protein_names_refseq": "paraneoplastic Ma antigen family member 6E; paraneoplastic antigen Ma6E isoform 2; paraneoplastic antigen Ma6E; putative paraneoplastic antigen-like protein 6B-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:649238)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;32488085;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A0A0J9YXQ4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43617-1",
        "uniprot_id": [
            {
                "id": "TPPC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43617",
                "type": "external"
            }
        ],
        "mass": 20274.0,
        "length": 180,
        "protein_name": "Trafficking protein particle complex subunit 3",
        "gene_name": "TRAPPC3",
        "organism": "Human",
        "refseq_name": "trafficking protein particle complex subunit 3 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001257824",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257824",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TRAPPC3; BET3; CDABP0066",
        "gene_names_refseq": "BET3; TRAPPC3",
        "protein_names_uniprotkb": "Trafficking protein particle complex subunit 3; BET3 homolog",
        "protein_names_refseq": "trafficking protein particle complex 3; trafficking protein particle complex subunit 3 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27095);  (R-HSA-204005);  (R-HSA-8876198)",
        "pathway_count": 3,
        "publication_count": 295,
        "publication_id_list": "10445031;10559959;10679020;10747087;10788476;10818110;10825291;10903204;10982397;10990452;11035026;11038176;11179213;11237011;11285137;11306556;11516400;11689439;11703925;11746448;11784320;11805826;11917121;11927603;12058051;12070132;12221131;12235121;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15037235;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692564;15692570;15728249;15878329;15914536;15958533;16207721;16262728;16303754;16373702;16410077;16495487;16525024;16525121;16571673;16624868;16641372;16754960;16828797;16880209;16912714;16950109;17005010;17038314;17043139;17132146;17189207;17192411;17208202;17239822;17287728;17316621;17488286;17562788;17574030;17646400;17671165;17678623;17684057;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;18843296;1900457;19109890;19164740;19345684;19403694;19416478;19490898;19620288;19638414;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20545907;20592283;20679433;20797862;20851765;20937701;20966969;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21478858;21525244;21532587;21554507;21586568;21683469;21689688;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22157747;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22675024;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23479643;23645161;23678941;23684622;23698585;23713133;23839779;23864707;24119662;24296415;24644286;24694596;24715725;24719330;24891604;24917561;24967941;25074980;25202031;25341920;25343031;25406594;25472813;25492864;25576301;25586378;25619252;25648148;25713415;25880248;25925668;26055712;26177209;26245486;26434594;26538022;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27600516;27846572;27862975;27920218;28228285;28832583;28834231;28904123;29242379;29331515;29493099;29508533;29557506;29632711;29789417;30315122;30410026;30484775;30779550;31222486;31530632;31682009;31844290;31848261;32157095;32161166;32357974;32488085;32502341;32938616;32983136;33091337;33123756;33298915;33592498;33717175;33912179;33968037;33981976;34087483;34171305;34509645;34932366;35051231;35318648;35580925;36215666;36241641;36284347;37938771;7688123;7911226;8144603;8221884;8408203;8522602;8620540;8663406;8863739;9020086;9020161;9030515;9094723;9136770;9150144;9177194;9307973;9323142;9564032;9590177;9647643;9733780",
        "class_list": "",
        "function": "Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus, [RefSeq, PubMed]; Crystal structure, [RefSeq, PubMed]; May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TRAPPC3 expression in healthy human palatal mucosa is strongly negatively correlated with serum cotinine levels., [RefSeq, PubMed]; The crystal structure of human Bet3-Tpc6B heterodimer presented here represents a core sub-complex in the assembly of TRAPP., [RefSeq, PubMed]; This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDN0;B2RDN2;D3DPS2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0033106 cis-Golgi network membrane",
        "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0006901 vesicle coating;GO:0099022 vesicle tethering",
        "synthesized_glycan_count": 0,
        "hit_score": 29.6,
        "record_id": "O43617-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92561-1",
        "uniprot_id": [
            {
                "id": "PHYIP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92561",
                "type": "external"
            }
        ],
        "mass": 37573.0,
        "length": 330,
        "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein",
        "gene_name": "PHYHIP",
        "organism": "Human",
        "refseq_name": "phytanoyl-CoA hydroxylase-interacting protein",
        "refseq_ac": [
            {
                "id": "NP_001092805",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092805",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHYHIP; DYRK1AP3; KIAA0273",
        "gene_names_refseq": "DYRK1AP3; PAHX-AP; PAHXAP1; PHYHIP",
        "protein_names_uniprotkb": "Phytanoyl-CoA hydroxylase-interacting protein; PAHX-AP1; PAHXAP1; Phytanoyl-CoA hydroxylase-associated protein 1",
        "protein_names_refseq": "DYRK1A interacting protein 3; PAHX-AP1; phytanoyl-CoA alpha-hydroxylase associated protein; phytanoyl-CoA hydroxylase-associated protein 1; phytanoyl-CoA hydroxylase-interacting protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9796)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "10686344;11237011;15694837;30379171;31154438;35051231;35494241;36215666;37949031",
        "class_list": "",
        "function": "High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia., [RefSeq, PubMed]; Its interaction with PHYH suggests a role in the development of the central system., [UniProtKB]; PAHX-AP1 may contribute to new cellular functions of DYRK1A and suggest that PAHX-AP1 may be involved in the development of neurological abnormalities observed in Down syndrome patients, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSR1;Q8N4I9",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990782 protein tyrosine kinase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0008104 intracellular protein localization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q92561-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NDG6-1",
        "uniprot_id": [
            {
                "id": "PGP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NDG6",
                "type": "external"
            }
        ],
        "mass": 34006.0,
        "length": 321,
        "protein_name": "Phosphoglycolate phosphatase",
        "gene_name": "PGP",
        "organism": "Human",
        "refseq_name": "glycerol-3-phosphate phosphatase",
        "refseq_ac": [
            {
                "id": "NP_001035830",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035830",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGP",
        "gene_names_refseq": "AUM; G3PP; PGPase; PGP",
        "protein_names_uniprotkb": "Phosphoglycolate phosphatase; 3.1.3.18; 3.1.3.21; 3.1.3.48; AUM; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; G3PP; Glycerol-3-phosphate phosphatase",
        "protein_names_refseq": "aspartate-based ubiquitous Mg(2+)-dependent phosphatase; glycerol-3-phosphate phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283871);  (R-HSA-1483206)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "11237011;1168700;12440769;15260917;15661399;15939762;16160620;18452278;215071;22284826;23301498;23481700;24338473;24715725;25002142;25418920;25576301;26154972;26375851;26755581;26992070;27294321;27544441;27920218;28218747;28228285;28510447;28514659;28832583;28904123;29242379;29314611;29437277;29524543;30315122;30379171;31092671;31530632;31844290;32157095;32161166;32387766;32502341;32897882;33123756;33141586;33298915;33491046;33592498;33912179;33936100;33968037;33981976;34019948;34171305;34229054;34357683;35051231;36215666;36241641;38272384;40596516;9430674",
        "class_list": "",
        "function": "'The available data indicate that St. John's wort is a potent induced of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs...' See page 262. Review article, [RefSeq, PubMed]; Cerp-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway GCS making a marked contribution to this resistance, [RefSeq, PubMed]; Data explain how PGP exerts control over EGF-induced cellular protein tyrosine phosphorylation, and reveal an unexpected influence of triacylglycerol turnover on growth factor signaling., [RefSeq, PubMed]; Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes., [RefSeq, PubMed]; Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Phosphatase with activity against multiple substrates (PubMed:27294321). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (PubMed:27294321). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (PubMed:26755581, PubMed:27294321). This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (PubMed:27294321). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (PubMed:27294321). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (PubMed:27294321). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (PubMed:27294321). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (PubMed:26755581). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (PubMed:26755581). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008967 phosphoglycolate phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006114 glycerol biosynthetic process;GO:0045721 negative regulation of gluconeogenesis;GO:0110052 toxic metabolite repair",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "A6NDG6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q504Y2-1",
        "uniprot_id": [
            {
                "id": "PKDCC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q504Y2",
                "type": "external"
            }
        ],
        "mass": 54132.0,
        "length": 493,
        "protein_name": "Extracellular tyrosine-protein kinase PKDCC",
        "gene_name": "PKDCC",
        "organism": "Human",
        "refseq_name": "extracellular tyrosine-protein kinase PKDCC precursor",
        "refseq_ac": [
            {
                "id": "NP_612379",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612379",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PKDCC; SGK493; VLK",
        "gene_names_refseq": "PKDCC; RLSDF; SGK493; Vlk",
        "protein_names_uniprotkb": "Extracellular tyrosine-protein kinase PKDCC; 2.7.10.2; Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; Sugen kinase 493; Vertebrate lonesome kinase",
        "protein_names_refseq": "extracellular tyrosine-protein kinase PKDCC precursor; extracellular tyrosine-protein kinase PKDCC; protein kinase domain containing, cytoplasmic homolog; protein kinase domain-containing protein, cytoplasmic; protein kinase-like protein SgK493; sugen kinase 493; vertebrate lonesome kinase",
        "tax_id": 9606,
        "disease": "intrinsic asthma (Disease Ontology:DOID:9360); rhizomelic limb shortening with dysmorphic features (MONDO:MONDO:0032935)",
        "pathway": " (hsa:91461)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;12471243;18077418;19961619;25171405;25813380;30478137;34329392;35051231;36896672;37217939;37592254;38483448;38683846",
        "class_list": "",
        "function": "A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Prenatal diagnosis to identify compound heterozygous variants in PKDCC that causes rhizomelic limb shortening with dysmorphic features in a fetus from China. Publication Status: Online-Only, [RefSeq, PubMed]; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity)., [UniProtKB, UniProtKB, PubMed]; The prevalence and phenotypic range associated with biallelic PKDCC variants., [RefSeq, PubMed]; The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W5A0;Q96I09",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0015031 protein transport;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation;GO:0048286 lung alveolus development;GO:0001501 skeletal system development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q504Y2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P4A8-1",
        "uniprot_id": [
            {
                "id": "LYLAP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P4A8",
                "type": "external"
            }
        ],
        "mass": 63255.0,
        "length": 553,
        "protein_name": "Lysosomal leucine aminopeptidase",
        "gene_name": "PLBD1",
        "organism": "Human",
        "refseq_name": "lysosomal leucine aminopeptidase precursor",
        "refseq_ac": [
            {
                "id": "NP_079105",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079105",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLBD1; Lylap",
        "gene_names_refseq": "LyLAP; PLBD1; PLBL1",
        "protein_names_uniprotkb": "Lysosomal leucine aminopeptidase; 3.4.11.-; LAMA-like protein 1; Lamina ancestor homolog 1; LyLAP; Phospholipase B domain-containing protein 1; Phospholipase B-like 1",
        "protein_names_refseq": "LAMA-like protein 1; PLB homolog 1; lamina ancestor homolog 1; lysosomal leucine aminopeptidase precursor; lysosomal leucine aminopeptidase; phospholipase B domain-containing protein 1; putative phospholipase B-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79887);  (R-HSA-1482788);  (R-HSA-1482839);  (R-HSA-1482922);  (R-HSA-1483115)",
        "pathway_count": 5,
        "publication_count": 79,
        "publication_id_list": "37639587;10085124;10092508;10092647;10336645;10358058;10455175;10681567;11031251;11112443;11237011;11790796;11830583;12150957;12161451;12359733;12522102;14709560;15695510;15863501;15944408;1618844;16243729;16617059;16704971;16818490;16864775;17182612;18094042;18195019;18287005;18458083;18614531;18772128;18781350;19019078;1904318;19159218;19351971;19501189;20705608;21515882;22605381;22825852;23090970;24190977;25645385;26375851;26463208;26503625;27862975;2925608;2925633;29314611;29557506;29741879;31154438;31756302;31848261;32157095;32387766;32488085;32938616;32983136;33091337;33141586;35051231;35580925;36284347;37074911;37217939;40146846;7060561;8083230;8300559;9188469;9417066;9525960;9705332",
        "class_list": "",
        "function": "Lysosomal processive monoaminopeptidase that preferentially cleaves hydrophobic amino acids, with strong preference for leucine residues. Plays a key role in the degradation of hydrophobic transmembrane domains within the lysosome., [UniProtKB, PubMed]; Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New Independent Predictors of Left Ventricular Dysfunction After Acute Myocardial Infarction., [RefSeq, PubMed]; Putative phospholipase., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 30,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4E9;Q9BVV3;Q9H625",
        "ec_number_list": [
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.4.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004177 aminopeptidase activity;GO:0004620 phospholipase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome",
        "go_biological_process": "GO:0006508 proteolysis;GO:1905146 lysosomal protein catabolic process;GO:0016042 lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q6P4A8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96GM8-1",
        "uniprot_id": [
            {
                "id": "TOE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96GM8",
                "type": "external"
            }
        ],
        "mass": 56548.0,
        "length": 510,
        "protein_name": "Target of EGR1 protein 1",
        "gene_name": "TOE1",
        "organism": "Human",
        "refseq_name": "target of EGR1 protein 1",
        "refseq_ac": [
            {
                "id": "NP_079353",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079353",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TOE1",
        "gene_names_refseq": "PCH7; TOE-1; TOE1; hCaf1z",
        "protein_names_uniprotkb": "Target of EGR1 protein 1",
        "protein_names_refseq": "target of EGR1 protein 1; target of EGR1, member 1 (nuclear)",
        "tax_id": 9606,
        "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 7 (Disease Ontology:DOID:0060276)",
        "pathway": " (hsa:114034)",
        "pathway_count": 1,
        "publication_count": 57,
        "publication_id_list": "12562764;17081983;18669648;18691976;18767875;19007248;19369195;19413330;19415658;19651622;19664995;20058876;20068231;21406692;23186163;24275569;26375851;26758079;26992070;27397612;27846572;27920218;28063628;28092684;28228285;28510447;28832583;28904123;29242379;29393594;29557506;29632046;29669292;29769354;30371886;30379171;30429286;31217245;31844290;32157095;32161166;32357974;32938616;33141586;33298915;33392160;33912179;33936100;33968037;35051231;35580925;36215666;36738896;37635087;37938771;40596516;40914422",
        "class_list": "",
        "function": "Genetic and prenatal diagnosis of a Chinese pedigree with pathogenic TOE1 variants causing pontocerebellar hypoplasia type 7., [RefSeq, PubMed]; Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684)., [UniProtKB, PubMed, PubMed]; Novel compound heterozygous missense variants in TOE1 gene associated with pontocerebellar hypoplasia type 7., [RefSeq, PubMed]; Our study highlights a mechanistic link between TOE1 mutation, improper hTR processing and telomere dysfunction in diseases such as Pontocerebella Hypoplasia Type 7 ., [RefSeq, PubMed]; PARN and TOE1 do not modulate the length of mRNA poly(A) tails. Rather, they promote the maturation of nuclear small non-coding RNAs (ncRNAs). PARN and TOE1 act redundantly on some ncRNAs, most prominently small Cajal body-specific RNAs (scaRNAs)., [RefSeq, PubMed]; TOE1 has a role in the growth inhibitory activity of Egr1, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DEM6;Q6IA35;Q8IWN5;Q9H846",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017069 snRNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0015030 Cajal body",
        "go_biological_process": "GO:0034472 snRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q96GM8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86XT4-1",
        "uniprot_id": [
            {
                "id": "TRI50_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86XT4",
                "type": "external"
            }
        ],
        "mass": 54728.0,
        "length": 487,
        "protein_name": "E3 ubiquitin-protein ligase TRIM50",
        "gene_name": "TRIM50",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase TRIM50 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001268379",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268379",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TRIM50; TRIM50A",
        "gene_names_refseq": "TRIM50A; TRIM50",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM50; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM50; Tripartite motif-containing protein 50",
        "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM50 isoform b; E3 ubiquitin-protein ligase TRIM50; RING-type E3 ubiquitin transferase TRIM50; tripartite motif-containing 50A; tripartite motif-containing protein 50",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:135892);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "11062501;11350924;12646216;14734113;15224091;15224092;15571818;16595681;16849449;16954532;18398435;18662542;19028597;19352404;19452197;19489725;19851334;19874575;19940261;2261476;22792322;24308962;29604308;29789583;30379171;37409971;9380723;9668046",
        "class_list": "",
        "function": "E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Encodes an E3 ubiquitin ligase; putatively involved in phenotype determination of Williams-Beuren syndrome., [RefSeq, PubMed]; TRIM50 Inhibits Gastric Cancer Progression by Regulating the Ubiquitination and Nuclear Translocation of JUP., [RefSeq, PubMed]; TRIM50 K372 residue competes for post-translational protein modifications such as acetylation and ubiquitination., [RefSeq, PubMed]; TRIM50 acted as a tumor suppressor in hepatocarcinoma cells by directly targeting SNAIL and reversing epithelial-to-mesenchymal transition. Erratum:[Cell Death Dis. 2018 Oct 9;9(10):1029. doi: 10.1038/s41419-018-0835-z. PMID: 30301954] Publication Status: Online-Only, [RefSeq, PubMed]; When the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M204;Q86XT3",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q86XT4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5JS54-1",
        "uniprot_id": [
            {
                "id": "PSMG4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JS54",
                "type": "external"
            }
        ],
        "mass": 13775.0,
        "length": 123,
        "protein_name": "Proteasome assembly chaperone 4",
        "gene_name": "PSMG4",
        "organism": "Human",
        "refseq_name": "proteasome assembly chaperone 4 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001122063",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122063",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMG4; C6orf86; PAC4",
        "gene_names_refseq": "C6orf86; PAC4; PSMG4; Pba4; bA506K6.2",
        "protein_names_uniprotkb": "Proteasome assembly chaperone 4; PAC-4; Pba4; Proteasome chaperone homolog 4; hPAC4",
        "protein_names_refseq": "proteasome (prosome, macropain) assembly chaperone 4; proteasome assembly chaperone 4 isoform b; proteasome chaperone homolog 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389362);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "10973495;11237011;15831487;16251969;16990800;17189198;17540904;17707236;17948026;19490896;20471946;23481700;23495936;24714562;24715725;25418920;25576301;26154972;26375851;26728094;26992070;27846572;28218747;28228285;28263418;28442575;28501589;28510447;28598414;28832583;28834231;29242379;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30410026;30484775;31092671;31217245;31844290;31848261;32157095;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;34087483;34171305;34211107;34932366;35051231;35251023;36010968;36284347",
        "class_list": "",
        "function": "A crystal structure of human PAC4 at 1.90-A resolution. Crystallographic data identify a hydrophobic surface that is surrounded by charged residues. The hydrophobic surface is complementary to that of its binding partner, PAC3., [RefSeq, PubMed]; Chaperone protein which promotes assembly of the 20S proteasome., [UniProtKB, UniProtKB]; PSMG4 and NLRP5 appear of particular interest as they were found to be associated with more than one clinical phenotype and are implicated in biological processes considered relevant to the pathophysiology of MS. Also, PSMG4 p.W99R and NLRP5 p.R761L were found to correlate with an earlier age of MS clinical onset. Our data suggests PSMG4 and NLPR5 as potential targets for the development of modifying therapies for MS., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9J2F8;F8WBZ2;Q5JS53;Q5JS56",
        "ec_number_list": [],
        "go_molecular_function": "GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0080129 proteasome core complex assembly;GO:0043248 proteasome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q5JS54-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14671-1",
        "uniprot_id": [
            {
                "id": "PUM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14671",
                "type": "external"
            }
        ],
        "mass": 126473.0,
        "length": 1186,
        "protein_name": "Pumilio homolog 1",
        "gene_name": "PUM1",
        "organism": "Human",
        "refseq_name": "pumilio homolog 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001018494",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018494",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PUM1; KIAA0099; PUMH1",
        "gene_names_refseq": "HSPUM; NEDMSF; PUM1; PUMH1; PUMH; PUML1; SCA47",
        "protein_names_uniprotkb": "Pumilio homolog 1; HsPUM; Pumilio-1",
        "protein_names_refseq": "pumilio homolog 1 isoform 1; pumilio homolog 1; pumilio-1",
        "tax_id": 9606,
        "disease": "cerebellar ataxia type 47 (Disease Ontology:DOID:0111743)",
        "pathway": " (hsa:9698);  (R-HSA-432722)",
        "pathway_count": 2,
        "publication_count": 149,
        "publication_id_list": "10394364;11237011;11336708;11590181;11604418;11694590;11994746;12202039;12459267;12771951;15102850;16155256;17081983;17116749;17322306;18212344;18328718;18669648;18691976;18707149;18767875;18776931;19651622;19664995;19690332;20068231;20818387;20860814;21397187;21406692;21572425;21653694;22121020;22345517;22955276;23125361;23186163;23301498;23783831;24129315;24275569;24366607;24715725;25340845;25645385;25768905;25892735;26154972;26724866;26992070;27600516;27846572;27920218;28228285;28431233;28510447;28514659;28657654;28832583;28834231;28904123;29237092;29242379;29331515;29351928;29393594;29474920;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30059200;30315122;30379171;30410026;30429286;30620550;30833945;30903679;31154438;31217245;31373491;31492838;31530632;31844290;31848261;31859446;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33592498;33633747;33691108;33717175;33912179;33968037;34171305;34211107;34357683;34509645;34725712;34932366;35051231;35132862;35138101;35251023;35254053;35318648;35386260;35513511;35580925;35705054;36010968;36241641;36284347;37074911;37340703;37469018;37541260;37938771;38029539;38081797;38275605;38471523;38665916;38838015;39531497;39534244;40307207;40596516;40914422;8374173;8524399;8670264",
        "class_list": "",
        "function": "A Circular RNA Derived from the Pumilio 1 Gene Could Regulate PTEN in Human Cumulus Cells. Publication Status: Online-Only, [RefSeq, PubMed]; PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated Glycolysis in Gastric Cancer., [RefSeq, PubMed]; PUM1 and PGK1 are Favorable Housekeeping Genes over Established Biodosimetry-related Housekeeping Genes such as HPRT1, ITFG1, DPM1, MRPS5, 18S rRNA and Others after Radiation Exposure., [RefSeq, PubMed]; Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer., [RefSeq, PubMed]; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1., [RefSeq, PubMed]; This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 24,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 24,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 24,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 26,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6W4;B4DG92;D3DPN3;E9PCJ0;Q53HH5;Q5VXY7;Q9HAN1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0000932 P-body",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0008344 adult locomotory behavior;GO:0048863 stem cell differentiation;GO:0060964 regulation of miRNA-mediated gene silencing",
        "synthesized_glycan_count": 0,
        "hit_score": 17.9,
        "record_id": "Q14671-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H6Z4-1",
        "uniprot_id": [
            {
                "id": "RANB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6Z4",
                "type": "external"
            }
        ],
        "mass": 60210.0,
        "length": 567,
        "protein_name": "Ran-binding protein 3",
        "gene_name": "RANBP3",
        "organism": "Human",
        "refseq_name": "ran-binding protein 3 isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001287794",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287794",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RANBP3",
        "gene_names_refseq": "RANBP3",
        "protein_names_uniprotkb": "Ran-binding protein 3; RanBP3",
        "protein_names_refseq": "epididymis secretory sperm binding protein; ran-binding protein 3 isoform 4; ran-binding protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8498)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "10.1101/2023.09.13.557529;10567565;11237011;11425870;11571268;11932251;17081983;17525332;18077418;18280241;18452278;18669648;19289081;19413330;19415658;19608861;19664994;19664995;19690332;20068231;20166139;20230923;21406692;22223895;23186163;23301498;23303829;24275569;24366607;25576301;26763446;28228285;28411811;28514659;28760339;28832583;28904123;29242379;29493099;29508533;29557506;29786170;30779550;31154438;31217245;31530632;31833110;31844290;31848261;32157095;32357974;32938616;32983136;33592498;33717175;33912179;33981976;34019948;34087483;34171305;34932366;35051231;35132862;35318648;35580925;37217939;37938771;40914422;9637251",
        "class_list": "",
        "function": "Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Computational docking simulation indicates that phosphorylation of RanBP3 at Ser58 could potentially stabilize the association of RanBP3 with importin-alpha through interactions between the phosphate moiety of phospho-Ser58 of RanBP3 and a cluster of basic residues (Arg96 and Lys97 in importin-alpha3) on armadillo repeat 1 of importin-alpha., [RefSeq, PubMed]; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner., [UniProtKB, UniProtKB]; RANBP3 regulates melanoma cell proliferation and probably a potential target for molecular targeted therapy., [RefSeq, PubMed]; Ran-binding protein 3 is associated with human spermatogenesis and male infertility., [RefSeq, PubMed]; RanBP3 is involved in vRNP nuclear export. The function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58. RanBP3 phosphorylation is modulated by both PI3K/Akt and Ras/ERK/RSK pathways in the late phase of viral infection., [RefSeq, PubMed]; This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 27,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAT8;O60405;O75759;O75760;Q9BT47;Q9UG74",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0070412 R-SMAD binding;GO:0046332 SMAD binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006611 protein export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q9H6Z4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z6L0-1",
        "uniprot_id": [
            {
                "id": "PRRT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z6L0",
                "type": "external"
            }
        ],
        "mass": 34945.0,
        "length": 340,
        "protein_name": "Proline-rich transmembrane protein 2",
        "gene_name": "PRRT2",
        "organism": "Human",
        "refseq_name": "proline-rich transmembrane protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243371",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243371",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRRT2",
        "gene_names_refseq": "BFIC2; BFIS2; DSPB3; DYT10; EKD1; FICCA; ICCA; IFITMD1; PKC; PRRT2",
        "protein_names_uniprotkb": "Proline-rich transmembrane protein 2; DSPB3; Dispanin subfamily B member 3",
        "protein_names_refseq": "Benign familial infantile convulsions-2; Paroxysmal kinesigenic dyskinesia; dispanin subfamily B member 3; dystonia 10; infantile convulsions and paroxysmal choreoathetosis; interferon induced transmembrane protein domain containing 1; proline-rich transmembrane protein 2 isoform 2",
        "tax_id": 9606,
        "disease": "benign familial infantile seizures 2 (Disease Ontology:DOID:0081115); episodic kinesigenic dyskinesia 1 (Disease Ontology:DOID:0090053); infantile convulsions and choreoathetosis (MONDO:MONDO:0011178)",
        "pathway": " (hsa:112476)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;16303743;18510355;19480736;22101681;22120146;22131361;22209761;22243967;22363774;22399141;22623405;22832103;25915028;27172900;29557506;31154438;32502341;33592498;36958475;37170076;37271286;37955636",
        "class_list": "",
        "function": "As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation., [UniProtKB, UniProtKB]; Effects of PRRT2 mutation on brain gray matter networks in paroxysmal kinesigenic dyskinesia., [RefSeq, PubMed]; Missense mutations in the membrane domain of PRRT2 affect its interaction with Nav1.2 voltage-gated sodium channels., [RefSeq, PubMed]; Peri-ictal EEG in infants with PRRT2-related self-limited infantile epilepsy., [RefSeq, PubMed]; The intramembrane COOH-terminal domain of PRRT2 regulates voltage-dependent Na[+] channels., [RefSeq, PubMed]; This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8M8;Q8N2N8;Q8NAQ7;Q8ND36;Q96FA8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017075 syntaxin-1 binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0043679 axon terminus;GO:0031982 vesicle",
        "go_biological_process": "GO:0035544 negative regulation of SNARE complex assembly;GO:0050884 neuromuscular process controlling posture;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:1905513 negative regulation of short-term synaptic potentiation;GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q7Z6L0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NNW5-1",
        "uniprot_id": [
            {
                "id": "WDR6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NNW5",
                "type": "external"
            }
        ],
        "mass": 121725.0,
        "length": 1121,
        "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6",
        "gene_name": "WDR6",
        "organism": "Human",
        "refseq_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001307475",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307475",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "WDR6",
        "gene_names_refseq": "Trm734; WDR6",
        "protein_names_uniprotkb": "tRNA (34-2'-O)-methyltransferase regulator WDR6; WD repeat-containing protein 6",
        "protein_names_refseq": "Trm734 homolog; WD repeat-containing protein 6; tRNA (34-2'-O)-methyltransferase regulator WDR6 isoform 2; tRNA (34-2'-O)-methyltransferase regulator WDR6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11180);  (R-HSA-9013420);  (R-HSA-9013424);  (R-HSA-9696264);  (R-HSA-9696270);  (R-HSA-9696273)",
        "pathway_count": 6,
        "publication_count": 120,
        "publication_id_list": "10664463;10903905;11237011;11459829;11784792;11940653;12244061;12842009;14521508;14732713;15004565;15350535;15556869;15738000;16481321;17216128;17355222;17504809;17720279;18996843;19064640;19103606;19136556;20547754;20811643;21508312;21565175;22223895;22339630;22354037;22424782;22645359;23481700;24690281;24714562;24715725;25418920;25505266;25576301;25645385;25880248;25888806;26154972;26242627;26375851;26598620;26728094;26969432;26992070;27600516;27846572;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30524438;31217245;31844290;31871319;32157095;32357974;32387766;32488085;32502341;32558197;32737221;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33771871;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34229054;34405274;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;36580660;37938771;38253038;8649376;9531558;9778532",
        "class_list": "",
        "function": "Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to SAMD9 or WDR6. Erratum:[mBio. 2017 Oct 31;8(5):e01735-17. doi: 10.1128/mBio.01735-17. PMID: 29089434] Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that WDR6 is implicated in the cell growth inhibitory pathway of LKB1 via regulation of p27(Kip1)., [RefSeq, PubMed]; This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]; Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transgenic rat gene WDR6 is expressed in the hypothalamus and interacts with insulin receptor substrate 4 (IRS-4) in the brain., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DHK2;Q3MIT1;Q9UF63",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0000049 tRNA binding;GO:0030234 enzyme regulator activity;GO:0140767 enzyme-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010507 negative regulation of autophagy;GO:0030488 tRNA methylation;GO:0070314 G1 to G0 transition;GO:0002130 wobble position ribose methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q9NNW5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96B01-1",
        "uniprot_id": [
            {
                "id": "R51A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96B01",
                "type": "external"
            }
        ],
        "mass": 38457.0,
        "length": 352,
        "protein_name": "RAD51-associated protein 1",
        "gene_name": "RAD51AP1",
        "organism": "Human",
        "refseq_name": "RAD51-associated protein 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001124334",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124334",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAD51AP1; PIR51",
        "gene_names_refseq": "PIR51; RAD51AP1",
        "protein_names_uniprotkb": "RAD51-associated protein 1; HsRAD51AP1; RAD51-interacting protein",
        "protein_names_refseq": "RAD51-associated protein 1 isoform a; RAD51-interacting protein; hsRAD51AP1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10635);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693568);  (R-HSA-5693579);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709603)",
        "pathway_count": 10,
        "publication_count": 143,
        "publication_id_list": "10.1101/2023.09.13.557529;10801132;10856253;11006276;11237011;11459987;11751635;12686547;12721304;12912992;14527420;14716019;14966907;15916957;16337601;16793542;16990250;17114795;17200668;17200671;17200672;17289582;17420451;17996710;17996711;18669648;18957201;19074197;19268590;19369211;19584259;19596236;19609323;19941829;20068231;20207730;20871615;20871616;20965415;21307306;21406692;21520333;21903585;22375013;22424782;22544926;22593209;22645308;23149936;23186163;23301498;23481700;23509288;23686288;23731732;23754376;24076221;24141787;24371268;24485656;24509834;24715725;24831703;25288561;25576301;26154972;26323318;26375851;26992070;27239033;27463890;27846572;27899578;27920218;28089683;28158555;28228285;28240985;28319063;28832583;28834231;28904123;29165669;29242379;29393594;29485866;29493099;29508533;29557506;29608566;29786170;30289697;30311374;30315122;30379171;30429286;30524438;30833945;31092671;31217245;31253762;31400850;31530632;31585101;31586400;31636395;31757951;31844290;31937595;31998317;32157095;32161166;32350107;32387766;32502341;32732220;32897882;32938616;33141586;33195396;33298915;33392160;33592498;33691108;33912179;33936100;33968037;34087483;34097859;34099522;34171305;34211107;34405274;34509645;34932366;35051231;35561310;36010968;36241641;37283490;37962862;38403248;9396801",
        "class_list": "",
        "function": "Expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues, [RefSeq, PubMed]; Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance., [RefSeq, PubMed]; Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks., [RefSeq, PubMed]; RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy., [RefSeq, PubMed]; RAD51AP1 has a selective affinity for branched-DNA structures that are obligatory intermediates during joint molecule formation., [RefSeq, PubMed]; RAD51AP1 helps maintain genomic integrity via RAD51 recombinase enhancement., [RefSeq, PubMed]; Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-kappaB signaling pathway., [RefSeq, PubMed]; ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7D3;O43403;Q7Z779",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0000217 DNA secondary structure binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0071479 cellular response to ionizing radiation;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "Q96B01-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UA1-1",
        "uniprot_id": [
            {
                "id": "PRP39_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UA1",
                "type": "external"
            }
        ],
        "mass": 78430.0,
        "length": 669,
        "protein_name": "Pre-mRNA-processing factor 39",
        "gene_name": "PRPF39",
        "organism": "Human",
        "refseq_name": "pre-mRNA-processing factor 39",
        "refseq_ac": [
            {
                "id": "NP_060392",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060392",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRPF39",
        "gene_names_refseq": "PRPF39",
        "protein_names_uniprotkb": "Pre-mRNA-processing factor 39; PRP39 homolog",
        "protein_names_refseq": "PRP39 homolog; PRP39 pre-mRNA processing factor 39 homolog; pre-mRNA-processing factor 39",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55015)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11237011;22773733;23481700;24275569;26992070;27920218;28063628;28218747;28832583;28904123;29242379;29437277;29632711;29786170;30397120;30429286;30949712;31217245;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32938616;33298915;33717175;33912179;33968037;34087483;34171305;34185709;35051231;35251023;36010968;36241641;36580660",
        "class_list": "",
        "function": "Involved in pre-mRNA splicing., [UniProtKB]; Knockdown of PRPF39 expression resulted in a significant expression change of downstream gene., [RefSeq, PubMed]; Organisms with higher splicing complexity have substituted the Prp39/Prp42 heterodimer with a PRPF39 homodimer, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q08AL1;Q08AL2;Q9NUU5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome",
        "go_biological_process": "GO:0000395 mRNA 5'-splice site recognition;GO:0006397 mRNA processing;GO:0008380 RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q86UA1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96C90-1",
        "uniprot_id": [
            {
                "id": "PP14B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96C90",
                "type": "external"
            }
        ],
        "mass": 15911.0,
        "length": 147,
        "protein_name": "Protein phosphatase 1 regulatory subunit 14B",
        "gene_name": "PPP1R14B",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 14B",
        "refseq_ac": [
            {
                "id": "NP_619634",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP1R14B; PLCB3N; PNG",
        "gene_names_refseq": "PHI-1; PLCB3N; PNG; PPP1R14B; SOM172",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14B; Phospholipase C-beta-3 neighbouring gene protein",
        "protein_names_refseq": "phospholipase C beta-3 neighboring gene protein; phospholipase C-beta-3 neighbouring gene protein; protein phosphatase 1 regulatory subunit 14B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26472)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "10606530;11237011;15083373;15522888;16964243;18212344;18491316;18669648;19415658;20068231;22223895;23186163;23301498;24715725;27846572;30429286;30779550;31217245;31844290;32488085;33592498;33936100;33968037;34171305;35154160;35494241;35679681;36484700;37261660;38136612;39216602;8838322",
        "class_list": "",
        "function": "An inhibitory phosphoprotein that inhibits the myosin- and glycogen-associated holoenzyme versions of protein type-1 phosphatase (PP1) as well as the monomeric catalytic subunit of PP1 in multiple tissues., [RefSeq, PubMed]; In vitro assessment of roles of PPP1R14B in cervical and endometrial cancer., [RefSeq, PubMed]; Inhibitor of PPP1CA., [UniProtKB, UniProtKB, UniProtKB]; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity)., [UniProtKB]; PHI-1 participates in regulatory events at the trailing edge of migrating cells and modulates retraction of endothelial and epithelial cells, [RefSeq, PubMed]; PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. Publication Status: Online-Only, [RefSeq, PubMed]; PPP1R14B-mediated phosphorylation enhances protein stability of RPS6KA1 to promote hepatocellular carcinoma tumorigenesis., [RefSeq, PubMed]; Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer., [RefSeq, PubMed]; Upregulated PPP1R14B is connected to cancer progression and immune infiltration in kidney renal clear cell carcinoma., [RefSeq, PubMed]; Whereas CPI-17 staining was diffuse, PHI-1 was concentrated along the cell membrane in distinct foci. The common tissue distribution but different cellular localization of PHI-1 and CPI-17 suggest distinctive physiological roles for these PP1 inhibitors., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q504S7;Q7KZD7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q96C90-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TAA3-1",
        "uniprot_id": [
            {
                "id": "PSMA8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TAA3",
                "type": "external"
            }
        ],
        "mass": 28530.0,
        "length": 256,
        "protein_name": "Proteasome subunit alpha-type 8",
        "gene_name": "PSMA8",
        "organism": "Human",
        "refseq_name": "proteasome subunit alpha-type 8 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001020267",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020267",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMA8; PSMA7L",
        "gene_names_refseq": "PSMA7L; PSMA8",
        "protein_names_uniprotkb": "Proteasome subunit alpha-type 8; Alpha4s; Proteasome alpha 4 subunit; Proteasome subunit alpha-type 7-like",
        "protein_names_refseq": "alpha4s; proteasome (prosome, macropain) subunit, alpha type, 8; proteasome alpha 4 subunit; proteasome subunit alpha 8; proteasome subunit alpha-type 8 isoform 2; proteasome subunit alpha-type 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:143471);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "10973495;11237011;12376572;15831487;16251969;16990800;17189198;17540904;17948026;19490896;20471946;22645359;24715725;26811146;26992070;28263418;28442575;28598414;29493099;29557506;30410026;33091337;33123756;34357683;35051231;36215666",
        "class_list": "",
        "function": "Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I., [UniProtKB, UniProtKB]; This article provides an overview of some of the components in the human 20 S proteasome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ75;Q8IVP4;Q8TA98;Q8TAA2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0019773 proteasome core complex, alpha-subunit complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q8TAA3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12272-1",
        "uniprot_id": [
            {
                "id": "PTHR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12272",
                "type": "external"
            }
        ],
        "mass": 20194.0,
        "length": 177,
        "protein_name": "Parathyroid hormone-related protein",
        "gene_name": "PTHLH",
        "organism": "Human",
        "refseq_name": "parathyroid hormone-related protein isoform 2 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_002811",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002811",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTHLH; PTHRP",
        "gene_names_refseq": "BDE2; HHM; PLP; PTHLH; PTHRP; PTHR",
        "protein_names_uniprotkb": "Parathyroid hormone-related protein; PLP; PTH-rP; PTHrP[107-139]; PTHrP; Parathyroid hormone-like protein",
        "protein_names_refseq": "PTH-rP; PTH-related protein; osteostatin; parathyroid hormone-like hormone preproprotein; parathyroid hormone-like related protein; parathyroid hormone-related protein isoform 2 preproprotein",
        "tax_id": 9606,
        "disease": "pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); brachydactyly type E2 (Disease Ontology:DOID:0110976); achondroplasia (Disease Ontology:DOID:4480)",
        "pathway": " (hsa:5744);  (R-HSA-373080);  (R-HSA-418555)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10.1038/emboj.2013.79;10050767;10097073;10373465;10873655;11007482;11159841;11237011;11297558;11401507;11742494;12036966;12058044;12098667;12106601;12180353;12391194;12504010;12538599;12559132;12852260;12860470;13549488;14671004;1517224;15199397;15389794;15498814;15765929;15769620;15951850;16313925;16602827;16687412;16923326;16959974;17168849;18044684;18577758;18801728;19105585;1915066;1954916;19674967;19876791;19929708;20128819;20170896;20381629;20637541;20878951;20966082;21036126;2163110;21932426;23584533;2417744;24687066;2491850;24992895;2553411;2553705;26417854;2708388;2744490;27549314;27703488;2829195;28416261;28622427;2871555;28832583;2885845;2928340;29443750;29602314;29938870;30459171;30833991;3127824;31279028;31399091;31983287;32157095;32226383;32236612;32350084;32497535;32540603;32618402;32715661;3290897;33049737;33437477;33592498;35251023;35932760;3616618;37664938;38407575;38552853;39174879;40138341;6085243;6950381;7797535;8082781;8198617;8340388;8386612;8397094;8514797;8557170;8612563;8672451;8732687;8770894;8906787;9048639;9064337;9144344;9263355;9417641;9651336",
        "class_list": "",
        "function": "A novel heterozygous mutation in PTHLH causing autosomal dominant brachydactyly type E complicated with short stature., [RefSeq, PubMed]; Alternative, in-frame translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG, give rise to nuclear forms of parathyroid hormone-related protein., [RefSeq, PubMed]; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed:12538599, PubMed:35932760, PubMed:3616618). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:19674967, PubMed:35932760). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (PubMed:12538599). Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (PubMed:12538599). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (By similarity). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1 (PubMed:20637541)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Osteostatin, a peptide for the future treatment of musculoskeletal diseases. Review article, [RefSeq, PubMed]; PTHrP participates in the bone destruction of middle ear cholesteatoma via promoting macrophage differentiation into osteoclasts induced by RANKL., [RefSeq, PubMed]; Potent inhibitor of osteoclastic bone resorption., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Role of Parathyroid Hormone and Parathyroid Hormone-Related Protein in Protein-Energy Malnutrition. Review article, [RefSeq, PubMed]; The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]., [RefSeq]; Translation initiation from non-AUG (CUG) start sites in the signal sequence, downstream of the initiator AUG codon, target PTHrP molecules exclusively to the nucleoli., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15251;Q6FH74",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "P12272-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q00888-1",
        "uniprot_id": [
            {
                "id": "PSG4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q00888",
                "type": "external"
            }
        ],
        "mass": 47113.0,
        "length": 419,
        "protein_name": "Pregnancy-specific beta-1-glycoprotein 4",
        "gene_name": "PSG4",
        "organism": "Human",
        "refseq_name": "pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002771",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002771",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSG4; CGM4; PSG9",
        "gene_names_refseq": "PSBG-4; PSG4",
        "protein_names_uniprotkb": "Pregnancy-specific beta-1-glycoprotein 4; PS-beta-G-4; PS-beta-G-9; PSBG-4; PSBG-9; Pregnancy-specific beta-1-glycoprotein 9; Pregnancy-specific glycoprotein 4; Pregnancy-specific glycoprotein 9",
        "protein_names_refseq": "PS-beta-G-4; Pregnancy-specific beta-1-glycoprotein-4; pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor; pregnancy-specific glycoprotein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5672);  (R-HSA-202733)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "10.1101/2023.09.13.557529;10606205;10764623;11207550;11237011;11256994;11564780;11779189;11812992;12070135;12208882;12469115;12782713;14529530;14615387;15000751;15528364;15681301;15721307;1591491;16258728;16297198;16585556;16691243;16737840;16783819;1690992;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;1922019;19279206;21193412;21659548;2271648;23090970;23945545;24043627;24190977;24764293;2538457;2783133;29557506;3180995;468991;7509040;7521878;7794280;8163559;8166770;8314844;9052782;9169774;9242610;9295288;9382878;9693095;9763524",
        "class_list": "",
        "function": "The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EX79;Q13047;Q13048;Q15234;Q15240;Q9UQ76",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q00888-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16401-1",
        "uniprot_id": [
            {
                "id": "PSMD5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16401",
                "type": "external"
            }
        ],
        "mass": 56196.0,
        "length": 504,
        "protein_name": "26S proteasome non-ATPase regulatory subunit 5",
        "gene_name": "PSMD5",
        "organism": "Human",
        "refseq_name": "26S proteasome non-ATPase regulatory subunit 5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001257356",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257356",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMD5; KIAA0072",
        "gene_names_refseq": "PSMD5; S5B",
        "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 5; 26S protease subunit S5 basic; 26S proteasome subunit S5B",
        "protein_names_refseq": "26S protease subunit S5 basic; 26S proteasome non-ATPase regulatory subunit 5 isoform 2; 26S proteasome non-ATPase regulatory subunit 5; 26S proteasome subunit S5B; proteasome (prosome, macropain) 26S subunit, non-ATPase, 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5711);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10973495;11237011;12665801;15831487;16251969;16990800;17189198;17540904;17948026;19217412;19412159;19490896;20471946;22223895;22898188;23982206;24714562;25418920;25880248;28063628;28263418;28442575;28510447;28598414;28832583;28904123;29242379;29393594;29557506;29632046;29632711;30315122;30379171;30429286;30524438;31154438;31217245;31222486;31611695;31844290;32157095;32161166;32350084;32357974;32502341;32938616;32983136;33214551;33298915;33592498;33717175;33968037;34019948;34087483;34357683;34725712;34932366;35051231;35580925;36010968;36241641;36580660;38665916;40914422;7559544",
        "class_list": "",
        "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5., [UniProtKB, PubMed, PubMed]; The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZM8;Q15045;Q4VXG8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005829 cytosol;GO:0000502 proteasome complex",
        "go_biological_process": "GO:0070682 proteasome regulatory particle assembly;GO:0043248 proteasome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q16401-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100010000000.010.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UN3-1",
        "uniprot_id": [
            {
                "id": "R4RL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UN3",
                "type": "external"
            }
        ],
        "mass": 46106.0,
        "length": 420,
        "protein_name": "Reticulon-4 receptor-like 2",
        "gene_name": "RTN4RL2",
        "organism": "Human",
        "refseq_name": "reticulon-4 receptor-like 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_848665",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848665",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RTN4RL2; NGRH1; NGRL3",
        "gene_names_refseq": "NGRH1; NgR2; RTN4RL2",
        "protein_names_uniprotkb": "Reticulon-4 receptor-like 2; NgR2; Nogo receptor-like 3; Nogo-66 receptor homolog 1; Nogo-66 receptor-related protein 2",
        "protein_names_refseq": "Nogo-66 receptor homolog 1; nogo receptor-like 3; nogo-66 receptor-related protein 2; reticulon-4 receptor-like 2 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:349667);  (R-HSA-163125)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11072085;11237011;12694398;12839991;14664809;15629437;18337405;21906273;22325200;23584533;2443973;24956133;25576301;29557506;32157095;3422494;35051231;35580925;36010968;36215666;36344556;37074911",
        "class_list": "",
        "function": "Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] Review article, [RefSeq, PubMed]; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Nogo-66 receptor homolog 1 signaling regulates activity-dependent synaptic strength and neuronal plasticity., [RefSeq, PubMed]; Predominantly expressed in the neurons of the embryonic and adult nervous systems, [RefSeq, PubMed]; The NOGO receptor NgR2, a novel alphaVbeta3 integrin effector, induces neuroendocrine differentiation in prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The release of N-terminal fragment-NgRH1 was blocked by a hydroxamate-based zinc metalloproteinase inhibitor and tissue inhibitor of metalloproteinases-2 and -3, [RefSeq, PubMed]; These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0GGW3;Q17RL9;Q6X813",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0051965 positive regulation of synapse assembly;GO:0022038 corpus callosum development;GO:0031103 axon regeneration",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q86UN3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43487-1",
        "uniprot_id": [
            {
                "id": "RANG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43487",
                "type": "external"
            }
        ],
        "mass": 23310.0,
        "length": 201,
        "protein_name": "Ran-specific GTPase-activating protein",
        "gene_name": "RANBP1",
        "organism": "Human",
        "refseq_name": "ran-specific GTPase-activating protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001265568",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265568",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RANBP1",
        "gene_names_refseq": "HTF9A; RANBP1",
        "protein_names_uniprotkb": "Ran-specific GTPase-activating protein; Ran-binding protein 1; RanBP1",
        "protein_names_refseq": "HpaII tiny fragments locus 9A; ran-specific GTPase-activating protein isoform 1; ran-specific GTPase-activating protein; testis secretory sperm-binding protein Li 221n",
        "tax_id": 9606,
        "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:5902);  (R-HSA-165054)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "11237011;11832950;11836381;14654843;14978097;16428860;16959974;17081983;17287340;17671426;18452278;18477386;18491316;18669648;19413330;1944575;19608861;19651622;19664994;20058876;20068231;20166139;20230923;20305658;20485264;20953181;21406692;21740066;23186163;23301498;23481700;24275569;24366607;25114211;25218447;25502872;25576301;25723178;25772364;25802875;25810538;25892735;26811146;26992070;27893789;27920218;28228285;28510447;28832583;28834231;28855257;28904123;29242379;29314611;29557506;29632711;30315122;31154438;31217245;31222486;31530632;31611695;31844290;31848261;31998317;32119511;32157095;32350084;32357974;32387766;32897882;32983136;33214551;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34357683;34509645;34725712;34974521;35051231;35132862;35138101;35251023;35580925;36010968;36215666;36581221;37047826;37217939;37938771;38011756;38665916;40596516;40914422;7616957;7878053;7882974;7891706;7958838;8805303;8896452;9837918",
        "class_list": "",
        "function": "CD147 supports paclitaxel resistance via interacting with RanBP1., [RefSeq, PubMed]; Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1., [RefSeq, PubMed]; Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53EY3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0045296 cadherin binding;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007165 signal transduction;GO:0051168 nuclear export;GO:0006913 nucleocytoplasmic transport",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "P43487-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31939-1",
        "uniprot_id": [
            {
                "id": "PUR9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31939",
                "type": "external"
            }
        ],
        "mass": 64616.0,
        "length": 592,
        "protein_name": "Bifunctional purine biosynthesis protein ATIC",
        "gene_name": "ATIC",
        "organism": "Human",
        "refseq_name": "bifunctional purine biosynthesis protein ATIC isoform 4",
        "refseq_ac": [
            {
                "id": "NP_004035",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004035",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ATIC; PURH; SW-cl.86",
        "gene_names_refseq": "AICARFT; AICAR; ATIC; HEL-S-70p; IMPCHASE; PURH",
        "protein_names_uniprotkb": "Bifunctional purine biosynthesis protein ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR formyltransferase; AICAR transformylase/inosine monophosphate cyclohydrolase; AICAR transformylase; ATIC; IMP synthase; Inosinicase",
        "protein_names_refseq": "5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein ATIC isoform 4; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase",
        "tax_id": 9606,
        "disease": "purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653); AICA-ribosiduria (MONDO:MONDO:0012099)",
        "pathway": " (hsa:471);  (R-HSA-73817);  (R-HSA-9725370)",
        "pathway_count": 3,
        "publication_count": 242,
        "publication_id_list": "10.1101/2023.09.13.557529;10216106;10556217;10702393;10706082;10706887;10934142;10958654;10985775;11096114;11110708;11237011;11280786;11310834;11381136;11504915;11751994;11850821;11943732;11948179;11988758;12112524;12185581;12424201;12450384;12750159;12800156;1286667;12920229;12934099;14529546;14756553;14756554;14962911;14966129;14978097;15114530;15116427;15169778;15208656;15374880;15588951;15786719;15895073;1592113;16153455;16161041;16170336;16408927;16825495;16871283;16939498;17086210;17224163;17353907;17416736;17483340;17625570;18083107;18097461;18388293;18452557;18593892;18594010;18609073;18701132;18724359;18923523;18923524;18923525;19456272;19459784;19608861;1967654;20068231;20454865;21134980;21164297;21213368;21320556;21415216;2147474;21494621;21596819;21656749;2183217;21838707;21847362;21960835;22223895;22249260;22327622;22347464;22424782;22544926;22570254;22658521;22898188;23104988;23139213;23201355;23239810;23301498;23481700;23661334;23957430;24060861;24366607;24445538;24475247;24496003;24518094;24613930;24714562;24715725;24736082;25342631;25393796;25418920;25421750;25576301;25645385;25687571;25813404;25892735;25921060;26001147;26062823;26154972;26301689;26375851;26728094;26768311;26811146;26992070;27245569;27573755;27600516;27869121;27874193;27920218;28228285;28404650;28467828;28514659;28659337;28741662;28832583;28834231;28855257;28904123;29072452;29242379;29314611;29331515;29393594;29455642;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;29873274;30131584;30315122;30397120;30524438;30692217;31366041;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35138101;35154160;35251023;35561310;35580925;35874702;36010968;36215666;36241641;36581221;36584330;37938771;38071832;38665916;39001904;40596516;40914422;4348202;4726295;762062;7706277;7824924;7903306;8089153;8110788;8366112;8380692;8567683;8633037;8867801;9378707;9819383",
        "class_list": "",
        "function": "A meta-analysis of the association between the ATIC 347 C/G polymorphism and methotrexate responsiveness and toxicity in rheumatoid arthritis., [RefSeq, PubMed]; Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients. Publication Status: Online-Only, [RefSeq, PubMed]; The kinetic mechanism of the human bifunctional enzyme ATIC, [RefSeq, PubMed]; This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K202;E9PBU3;Q13856;Q53S28",
        "ec_number_list": [
            {
                "id": "2.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.3",
                "type": "external"
            },
            {
                "id": "3.5.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.10",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding;GO:0003937 IMP cyclohydrolase activity;GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0003360 brainstem development;GO:0046654 tetrahydrofolate biosynthetic process;GO:0021987 cerebral cortex development;GO:0031100 animal organ regeneration;GO:0006139 nucleobase-containing compound metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 24.7,
        "record_id": "P31939-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13686-1",
        "uniprot_id": [
            {
                "id": "PPA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13686",
                "type": "external"
            }
        ],
        "mass": 36599.0,
        "length": 325,
        "protein_name": "Tartrate-resistant acid phosphatase type 5",
        "gene_name": "ACP5",
        "organism": "Human",
        "refseq_name": "tartrate-resistant acid phosphatase type 5 precursor",
        "refseq_ac": [
            {
                "id": "NP_001104504",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104504",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ACP5",
        "gene_names_refseq": "ACP5; HPAP; TRACP5a; TRACP5b; TRAP; TRAcP; TrATPase",
        "protein_names_uniprotkb": "Tartrate-resistant acid phosphatase type 5; 3.1.3.2; TR-AP; Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase",
        "protein_names_refseq": "human purple acid phosphatase; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b; tartrate-resistant acid phosphatase type 5 precursor; tartrate-resistant acid phosphatase type 5",
        "tax_id": 9606,
        "disease": "spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); Spondyloenchondrodysplasia with immune dysregulation (MONDO:MONDO:0011939)",
        "pathway": " (hsa:54);  (R-HSA-196843)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "11237011;12623014;1477968;15993892;16643857;18632736;1872798;20206331;20463145;21081667;21110228;21217752;21217755;2334436;2338077;24264046;25502872;25645385;2610679;26992070;27452731;2775236;27862975;28446606;28467828;28832583;28834231;2909539;29242379;29393594;29557506;29632711;29786170;29789417;30573663;31154438;31844290;31848261;32157095;32162841;32350084;32983136;33043033;33592498;33936100;35051231;35102444;35154160;35251023;35580925;36284347;36637040;37010587;37382551;38879488;39894887;8001561;8359686",
        "class_list": "",
        "function": "Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias., [UniProtKB]; Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial., [RefSeq, PubMed]; Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations., [RefSeq, PubMed]; Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases., [RefSeq, PubMed]; The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis., [RefSeq, PubMed]; This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3V2;Q2TAB1;Q6IAS6;Q9UCJ5;Q9UCJ6;Q9UCJ7",
        "ec_number_list": [
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome",
        "go_biological_process": "GO:0045453 bone resorption",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "P13686-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15907-1",
        "uniprot_id": [
            {
                "id": "RB11B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15907",
                "type": "external"
            }
        ],
        "mass": 24489.0,
        "length": 218,
        "protein_name": "Ras-related protein Rab-11B",
        "gene_name": "RAB11B",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-11B",
        "refseq_ac": [
            {
                "id": "NP_004209",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004209",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAB11B; YPT3",
        "gene_names_refseq": "H-YPT3; NDAGSCW; RAB11B",
        "protein_names_uniprotkb": "Ras-related protein Rab-11B; 3.6.5.2; GTP-binding protein YPT3",
        "protein_names_refseq": "GTP-binding protein YPT3; RAB11B, member of RAS oncogene family; ras-related protein Rab-11B",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter (Disease Ontology:DOID:0070753); intestinal cancer (Disease Ontology:DOID:10155)",
        "pathway": " (hsa:9230);  (R-HSA-8854214);  (R-HSA-8873719)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "10202141;11141079;11237011;11389151;11447212;11495908;11675392;14627637;16055087;16395330;16401880;1648736;16545962;17114793;17411337;17658474;17901050;18199687;18319245;18466115;18532927;18578522;19029296;19244346;19603039;20068231;20095038;20116244;20363736;20404108;20717956;21248079;21255211;21383079;21458671;21976701;22129970;22219378;22613832;22645359;22694141;22762500;22795129;22854040;23019362;23562278;23572552;24023390;24715725;25341920;25576301;25673879;26032412;26969162;26992070;27090790;27452731;27726376;27920218;28218747;28228285;28467828;28514659;28832583;28834231;28855257;29106825;29242379;29314611;29393594;29437277;29493099;29557506;29632711;29769354;29774024;29786170;29789417;30315122;30429286;30573663;30661770;30779550;30833945;31154438;31204173;31530632;31844290;31848261;31998317;32974215;33465208;33524390;33968037;34357683;34433824;34932366;35580925;36052645;36241641;36581221;40596516;7811277;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8836150",
        "class_list": "",
        "function": "Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation., [RefSeq, PubMed]; The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Also interacts with RABL3 to promote ciliary vesicle formation (PubMed:36052645)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5YM50;B2R7I4;B4DMK0;D6W671;Q2YDT2;Q5U0I1;Q6FHR0;Q6FI42;Q8NI07",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0045296 cadherin binding;GO:0019003 GDP binding;GO:0031489 myosin V binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0070062 extracellular exosome;GO:0030670 phagocytic vesicle membrane",
        "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0045055 regulated exocytosis;GO:0001881 receptor recycling;GO:0032456 endocytic recycling;GO:0032402 melanosome transport",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q15907-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TBY0-1",
        "uniprot_id": [
            {
                "id": "RBM46_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TBY0",
                "type": "external"
            }
        ],
        "mass": 60023.0,
        "length": 533,
        "protein_name": "Probable RNA-binding protein 46",
        "gene_name": "RBM46",
        "organism": "Human",
        "refseq_name": "probable RNA-binding protein 46 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001264100",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264100",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM46",
        "gene_names_refseq": "CT68; RBM46",
        "protein_names_uniprotkb": "Probable RNA-binding protein 46; CT68; Cancer/testis antigen 68; RNA-binding motif protein 46",
        "protein_names_refseq": "cancer/testis antigen 68; probable RNA-binding protein 46 isoform 2; probable RNA-binding protein 46",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:166863)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;30379171;34561969;35051231;35318648;35580925;36001654;38708190;38740147",
        "class_list": "",
        "function": "Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (By similarity). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (By similarity). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (By similarity). Required for spermatogonial differentiation in both developing and adult testis (By similarity)., [UniProtKB, UniProtKB]; Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity., [RefSeq, PubMed]; RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWU8;B4DZ27",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0140767 enzyme-substrate adaptor activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030895 apolipoprotein B mRNA editing enzyme complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0007143 female meiotic nuclear division;GO:0007140 male meiotic nuclear division;GO:0048477 oogenesis;GO:0048515 spermatid differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8TBY0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKI9-1",
        "uniprot_id": [
            {
                "id": "PO2F3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKI9",
                "type": "external"
            }
        ],
        "mass": 47432.0,
        "length": 436,
        "protein_name": "POU domain, class 2, transcription factor 3",
        "gene_name": "POU2F3",
        "organism": "Human",
        "refseq_name": "POU domain, class 2, transcription factor 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001231611",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231611",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POU2F3; OTF11; PLA1",
        "gene_names_refseq": "Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; POU2F3; Skn-1a",
        "protein_names_uniprotkb": "POU domain, class 2, transcription factor 3; OTF-11; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11; Transcription factor PLA-1; Transcription factor Skn-1",
        "protein_names_refseq": "POU domain transcription factor OCT11a; POU domain, class 2, transcription factor 3 isoform 2; POU domain, class 2, transcription factor 3; octamer-binding protein 11; octamer-binding transcription factor 11; transcription factor PLA-1; transcription factor Skn-1",
        "tax_id": 9606,
        "disease": "immune system disease (Disease Ontology:DOID:2914)",
        "pathway": " (hsa:25833)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "10473598;11237011;11329378;16607278;22645359;23481700;29242379;30379171;30397120;30410026;31848261;32357974;32387766;32983136;33912179;35051231;35576971;36010968;36197978;36716535;36815540;37904277;38253038;39029464",
        "class_list": "",
        "function": "An integrated multiomics analysis of rectal cancer patients identified POU2F3 as a putative druggable target and entinostat as a cytotoxic enhancer of 5-fluorouracil., [RefSeq, PubMed]; Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer., [RefSeq, PubMed]; POU2F3 in cervical cancer cells may be CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms., [RefSeq, PubMed]; POU2F3-Expressing Small Cell Lung Carcinoma and Large Cell Neuroendocrine Carcinoma Show Morphologic and Phenotypic Overlap., [RefSeq, PubMed]; The predictive value of YAP-1 and POU2F3 for the efficacy of immuno-chemotherapy in extensive-stage SCLC patients., [RefSeq, PubMed]; This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7H8;B4DY07;F5GWW6;Q3MIY3;Q9UKR7;Q9Y504",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9UKI9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31040-1",
        "uniprot_id": [
            {
                "id": "SDHA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31040",
                "type": "external"
            }
        ],
        "mass": 72692.0,
        "length": 664,
        "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
        "gene_name": "SDHA",
        "organism": "Human",
        "refseq_name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001281261",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281261",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SDHA; SDH2; SDHF",
        "gene_names_refseq": "CMD1GG; FP; MC2DN1; NDAXOA; PGL5; PPGL5; SDH1; SDH2; SDHA; SDHF",
        "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Flavoprotein subunit of complex II; Fp; Malate dehydrogenase [quinone] flavoprotein subunit",
        "protein_names_refseq": "flavoprotein subunit of complex II; malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex, subunit A, flavoprotein (Fp)",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 5 (Disease Ontology:DOID:0061220); dilated cardiomyopathy 1GG (Disease Ontology:DOID:0110435); leukodystrophy (Disease Ontology:DOID:10579); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); Leigh disease (Disease Ontology:DOID:3652); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); neurodegeneration with ataxia and late-onset optic atrophy (MONDO:MONDO:0031006)",
        "pathway": " (hsa:6389);  (R-HSA-611105);  (R-HSA-71403);  (R-HSA-9854311)",
        "pathway_count": 4,
        "publication_count": 139,
        "publication_id_list": "10327278;1052766;10673423;10727444;10746566;10976639;11237011;11278619;11695836;12207025;12231006;12794685;12837546;13181903;1327877;14249115;14555658;14741580;14832224;14946179;15234968;15242332;15247478;15250827;15652751;15877282;15987702;16143825;16230336;16737955;16740313;17033964;17182618;17432878;17668387;17923681;17997986;186667;18806796;18914071;1946331;19608861;19628817;2005110;20068231;20167786;20435888;20484225;20551992;20847235;22416140;22823520;22972948;23150584;23270816;23301498;23564345;23747254;239860;24781757;24954416;24954417;25564869;25576301;25892735;26642834;26749241;27189937;27374498;27452731;27600516;27683074;28228285;28380382;28391595;28514659;28593945;28649982;28887308;28904123;29242379;29393594;29493099;29557506;29769354;29786170;30429286;30484775;30761759;30844107;31217245;31373491;31844290;32119511;32157095;32350084;32357974;32387766;32887801;32897882;32938616;33058874;33141586;33465208;33912179;34019948;34087483;34289383;34357683;34725712;35051231;35251023;35366151;35580925;36139014;36215666;36241641;36420423;36980917;37098072;37217939;38665916;39083879;39133175;40596516;40914422;4288886;7550341;7798181;8142412;8200987;8616157;9765290;9765291;9792106;9792662;9809442;9878551;9989622",
        "class_list": "",
        "function": "Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10746566, PubMed:24781757). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (PubMed:20484225)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update. Review article Publication Status: Online-Only, [RefSeq, PubMed]; SDHA-related phaeochromocytoma and paraganglioma: review and clinical management. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Succinate dehydrogenase A deficient renal cell carcinoma: A rare renal tumor distinct from typical Succinate dehydrogenase deficient renal cell carcinoma., [RefSeq, PubMed]; This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5J6;B4DJ60;E9PBJ5;Q16395;Q59GW8;Q8IW48;Q9UMY5",
        "ec_number_list": [
            {
                "id": "1.3.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1",
                "type": "external"
            },
            {
                "id": "1.1.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0008177 succinate dehydrogenase (quinone) activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045273 respiratory chain complex II (succinate dehydrogenase)",
        "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0007399 nervous system development;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0006105 succinate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "P31040-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13046-1",
        "uniprot_id": [
            {
                "id": "PSG7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13046",
                "type": "external"
            }
        ],
        "mass": 47027.0,
        "length": 419,
        "protein_name": "Pregnancy-specific beta-1-glycoprotein 7",
        "gene_name": "PSG7",
        "organism": "Human",
        "refseq_name": "pregnancy-specific beta-1-glycoprotein 7 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002774",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002774",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSG7",
        "gene_names_refseq": "PS-beta-G-7; PSBG-7; PSG7; PSGGA",
        "protein_names_uniprotkb": "Pregnancy-specific beta-1-glycoprotein 7; PS-beta-G-7; PSBG-7; Pregnancy-specific glycoprotein 7",
        "protein_names_refseq": "pregnancy-specific beta-1-glycoprotein 7 isoform 1 precursor; pregnancy-specific glycoprotein 7; putative pregnancy-specific beta-1-glycoprotein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5676);  (R-HSA-202733)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "10606205;10764623;11207550;11237011;11256994;11564780;11779189;11812992;12070135;12208882;12469115;12782713;14529530;14615387;15000751;15528364;15681301;15721307;1591491;16258728;16297198;16585556;16691243;16737840;16783819;1690992;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;19279206;21193412;21659548;23945545;24043627;24764293;2538457;30315122;31844290;32157095;35322669;468991;7509040;7521878;7794280;8163559;8166770;8314844;9052782;9169774;9242610;9295288;9382878;9693095;9763524",
        "class_list": "",
        "function": "PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia., [RefSeq, PubMed]; This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WSZ1;Q15232",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q13046-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11117-1",
        "uniprot_id": [
            {
                "id": "PPAL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11117",
                "type": "external"
            }
        ],
        "mass": 48344.0,
        "length": 423,
        "protein_name": "Lysosomal acid phosphatase",
        "gene_name": "ACP2",
        "organism": "Human",
        "refseq_name": "lysosomal acid phosphatase isoform 5 precursor",
        "refseq_ac": [
            {
                "id": "NP_001289420",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289420",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ACP2",
        "gene_names_refseq": "ACP2; LAP",
        "protein_names_uniprotkb": "Lysosomal acid phosphatase; 3.1.3.2; LAP; Tartrate-inhibitable acid phosphatase",
        "protein_names_refseq": "lysosomal acid phosphatase isoform 5 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53)",
        "pathway_count": 1,
        "publication_count": 61,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;11237011;15503243;19159218;23090970;24190977;24715725;25576301;25892735;2684640;26992070;2776754;28272419;28467828;28832583;28834231;28904123;29242379;29393594;29557506;29741879;29769354;29786170;30192525;30237853;30484775;3056714;31154438;31844290;3191910;32157095;32350084;32387766;32488085;32574038;32897882;32983136;33381921;33592498;33912179;34019948;34087483;34089345;34357683;34725712;34932366;35051231;35251023;35254053;35289036;35318648;35580925;36215666;36241641;36284347;37074911;38665916;5410815;6090300;9228031",
        "class_list": "",
        "function": "(Microbial infection) Plays a crucial role in the membrane fusion step of the influenza A and B viruses entry process., [UniProtKB, PubMed]; An enzymatically inactive allele of mouse Acp2 causes cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype., [RefSeq, PubMed]; Clinical and molecular evaluation of 13 Brazilian patients with Gomez-Lopez-Hernandez syndrome., [RefSeq, PubMed]; LAP-deficient mice exhibit multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures., [RefSeq, PubMed]; Lysosomal acid phosphatase that catalyzes the hydrolysis of orthophosphoric monoesters to alcohols and phosphate under acidic conditions (Probable) (PubMed:6090300). May contribute to the removal of mannose-6-phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP5 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 71,
        "disease_count": 0,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PCI1;Q561W5;Q9BTU7",
        "ec_number_list": [
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003993 acid phosphatase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0007040 lysosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "P11117-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55895-1",
        "uniprot_id": [
            {
                "id": "RAG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55895",
                "type": "external"
            }
        ],
        "mass": 59241.0,
        "length": 527,
        "protein_name": "V(D)J recombination-activating protein 2",
        "gene_name": "RAG2",
        "organism": "Human",
        "refseq_name": "V(D)J recombination-activating protein 2",
        "refseq_ac": [
            {
                "id": "NP_000527",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000527",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAG2",
        "gene_names_refseq": "RAG-2; RAG2",
        "protein_names_uniprotkb": "V(D)J recombination-activating protein 2; RAG-2",
        "protein_names_refseq": "V(D)J recombination-activating protein 2; recombination activating gene 2",
        "tax_id": 9606,
        "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); severe combined immunodeficiency (Disease Ontology:DOID:627)",
        "pathway": " (hsa:5897);  (R-HSA-1266695);  (R-HSA-5687128)",
        "pathway_count": 3,
        "publication_count": 108,
        "publication_id_list": "10470034;10975528;11237011;11418668;11564764;11584266;11728342;11804587;12184921;12205088;12546821;12808096;12889071;12915405;1428003;14593182;15226418;15353558;15538386;15577943;15749844;16360641;16371649;16971392;16973613;17161475;17254968;17395884;17562296;17728103;17947239;18031682;18162290;18235225;18248330;1832998;18463379;18593949;18644862;18720373;19166925;19473979;19513348;19593530;19864382;20236090;20536836;20543837;20734105;20849292;21105711;21177870;21317288;21329875;21329882;21372320;22267219;22279049;22464331;22505454;22508986;22800433;23069990;2317865;23878308;24309468;24417533;24585635;25339975;25576301;26301565;26974155;27423467;29069605;29139090;29557506;29774024;30484775;31154438;31918398;32897882;36215666;36270284;36279417;37573280;37724703;38350907;7489741;7514277;7559638;7719938;7799959;8107774;8128231;8146183;8266077;8493533;8702919;8709637;8810255;9233603;9398404;9535855;9553136;9628874;9630231;9715265;9747882",
        "class_list": "",
        "function": "A novel loss of function mutation in the PHD domain of the RAG2 gene, affecting zinc-binding affinity., [RefSeq, PubMed]; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)., [UniProtKB]; From variant of uncertain significance to likely pathogenic in two siblings with atypical RAG2 Deficiency: a case report and review of the literature. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Heterogeneity in RAG1 and RAG2 deficiency: 35 cases from a single-centre., [RefSeq, PubMed]; Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT., [RefSeq, PubMed]; Rag2(-/-) accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies. Erratum:[Stem Cell Reports. 2023 Jan 10;18(1):413-415. doi: 10.1016/j.stemcr.2022.11.023. PMID: 36630907], [RefSeq, PubMed]; This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9E9;Q8TBL4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0030183 B cell differentiation;GO:0033077 T cell differentiation in thymus;GO:0002331 pre-B cell allelic exclusion;GO:0033151 V(D)J recombination;GO:0033085 negative regulation of T cell differentiation in thymus",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "P55895-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02325-1",
        "uniprot_id": [
            {
                "id": "PLGB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02325",
                "type": "external"
            }
        ],
        "mass": 10971.0,
        "length": 96,
        "protein_name": "Plasminogen-like protein B",
        "gene_name": "PLGLB1; PLGLB2",
        "organism": "Human",
        "refseq_name": "plasminogen-like protein B precursor",
        "refseq_ac": [
            {
                "id": "NP_001027564",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027564",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLGLB1; PLGLB2; PLGL; PLGP1; PRGB",
        "gene_names_refseq": "PLGLB1; PLGL; PLGP1; PRGB; PRP-B",
        "protein_names_uniprotkb": "Plasminogen-like protein B; Plasminogen-related protein B",
        "protein_names_refseq": "plasminogen-like protein B precursor; plasminogen-like protein B; plasminogen-related protein B; type B plasminogen related",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5342);  (hsa:5343)",
        "pathway_count": 2,
        "publication_count": 9,
        "publication_id_list": "11237011;1379800;1554698;19824718;19913121;20628086;29557506;30459171;31848261",
        "class_list": "",
        "function": "May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction., [UniProtKB]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q580R1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q02325-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N7P1-1",
        "uniprot_id": [
            {
                "id": "PLD5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N7P1",
                "type": "external"
            }
        ],
        "mass": 61312.0,
        "length": 536,
        "protein_name": "Inactive phospholipase D5",
        "gene_name": "PLD5",
        "organism": "Human",
        "refseq_name": "inactive phospholipase D5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001182740",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182740",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLD5",
        "gene_names_refseq": "PLD5; PLDC",
        "protein_names_uniprotkb": "Inactive phospholipase D5; Inactive PLD 5; Inactive choline phosphatase 5; Inactive phosphatidylcholine-hydrolyzing phospholipase D5; PLDc",
        "protein_names_refseq": "inactive PLD 5; inactive choline phosphatase 5; inactive phosphatidylcholine-hydrolyzing phospholipase D5; inactive phospholipase D5 isoform 2; inactive phospholipase D5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:200150)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;19626040;20663923;24715725;32488085;33141586;34087483;34238129;35051231;35580925;37217939",
        "class_list": "",
        "function": "MicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to downregulate cell proliferation and metastasis to mitigate prostate cancer., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1KXV0;B7Z324;Q494U9;Q8NB22",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8N7P1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95456-1",
        "uniprot_id": [
            {
                "id": "PSMG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95456",
                "type": "external"
            }
        ],
        "mass": 32854.0,
        "length": 288,
        "protein_name": "Proteasome assembly chaperone 1",
        "gene_name": "PSMG1",
        "organism": "Human",
        "refseq_name": "proteasome assembly chaperone 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_003711",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003711",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMG1; C21LRP; DSCR2; PAC1",
        "gene_names_refseq": "C21LRP; DSCR2; LRPC21; PAC-1; PAC1; PSMG1; Pba1",
        "protein_names_uniprotkb": "Proteasome assembly chaperone 1; C21-LRP; Chromosome 21 leucine-rich protein; Down syndrome critical region protein 2; PAC-1; Pba1; Proteasome chaperone homolog 1",
        "protein_names_refseq": "Down syndrome critical region gene 2; Down syndrome critical region protein 2; chromosome 21 leucine-rich protein; leucine rich protein C21-LRP; proteasome (prosome, macropain) assembly chaperone 1; proteasome assembling chaperone 1; proteasome assembly chaperone 1 isoform a; proteasome chaperone homolog 1",
        "tax_id": 9606,
        "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); autosomal dominant nonsyndromic deafness 83 (Disease Ontology:DOID:0070609); hypothyroidism (Disease Ontology:DOID:1459)",
        "pathway": " (hsa:8624);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "10872820;10973495;11237011;15590417;15670775;15831487;16251969;16990800;17189198;17540904;17707236;17924679;17948026;19054851;19490896;19608861;19651622;20068231;20471946;22223895;23186163;23301498;23481700;23495936;24715725;25576301;25645385;25892735;26109405;26154972;26375851;26992070;27397612;27846572;27920218;28218747;28228285;28263418;28442575;28510447;28514659;28598414;28832583;28834231;28904123;29242379;29437277;29493099;29508533;29557506;29769354;29786170;29789417;30059200;30315122;30429286;30524438;30779550;31154438;31217245;31844290;32157095;32338277;32350084;32357974;32488085;32502341;32897882;32938616;33141586;33214551;33298915;33592498;33691108;33717175;33912179;33936100;33981976;34019948;34171305;34211107;34229054;34357683;34509645;34561969;34932366;35051231;35138101;35251023;35318648;35561310;36010968;36284347;36581221;38665916;40596516;9784380",
        "class_list": "",
        "function": "Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization., [UniProtKB, PubMed, PubMed]; Further, the results of intracellular localization studies and membrane fractionation assays indicate that DSCR2 is targeted to a cytoplasmic compartment as a soluble form., [RefSeq, PubMed]; MiR-484 is associated with disease recurrence and promotes migration in prostate cancer., [RefSeq, PubMed]; The DSCR2 protein is associated with the endoplasmic reticulum; it is not an integral membrane protein and it is maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein., [RefSeq, PubMed]; Two chaperones, designated proteasome assembling chaperone-1 (PAC1) and PAC2, form a heterodimer and are involved in the maturation of mammalian 20S proteasomes, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BUN2;Q6FHA3;Q6FHD3;Q6S713",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0070628 proteasome binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0080129 proteasome core complex assembly;GO:0051131 chaperone-mediated protein complex assembly;GO:0043248 proteasome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "O95456-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E9PB15-1",
        "uniprot_id": [
            {
                "id": "PTG3L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E9PB15",
                "type": "external"
            }
        ],
        "mass": 19074.0,
        "length": 166,
        "protein_name": "Putative protein PTGES3L",
        "gene_name": "PTGES3L",
        "organism": "Human",
        "refseq_name": "putative protein PTGES3L isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001136126",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136126",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTGES3L",
        "gene_names_refseq": "PTGES3L",
        "protein_names_uniprotkb": "Putative protein PTGES3L; Prostaglandin E synthase 3-like",
        "protein_names_refseq": "prostaglandin E synthase 3 (cytosolic)-like; putative protein PTGES3L isoform 4; putative protein PTGES3L",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100885848)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;39894887",
        "class_list": "",
        "function": "Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9A003",
        "ec_number_list": [
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0050220 prostaglandin-E synthase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0001516 prostaglandin biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "E9PB15-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6MZQ0-1",
        "uniprot_id": [
            {
                "id": "PRR5L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6MZQ0",
                "type": "external"
            }
        ],
        "mass": 40836.0,
        "length": 368,
        "protein_name": "Proline-rich protein 5-like",
        "gene_name": "PRR5L",
        "organism": "Human",
        "refseq_name": "proline-rich protein 5-like isoform a",
        "refseq_ac": [
            {
                "id": "NP_001153639",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153639",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRR5L; PROTOR2",
        "gene_names_refseq": "PROTOR2; PRR5L",
        "protein_names_uniprotkb": "Proline-rich protein 5-like; Protein observed with Rictor-2; Protor-2",
        "protein_names_refseq": "Protein observed with Rictor-2; proline-rich protein 5-like isoform a; proline-rich protein 5-like; protor-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79899)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;17461779;20877624;21964062;22609986;25576301;28832583;29242379;29789417;30429286;31848261;32157095;32387766;32488085;32938616;32983136;33592498;33968037;34185709;35051231;36010968",
        "class_list": "",
        "function": "Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062)., [UniProtKB, PubMed, PubMed, PubMed]; It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 results in the co-immunoprecipitation of other mTORC2 subunits, but not Raptor, a specific component of mTORC1., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Protor-2 associates with tristetraprolin (TTP) to accelerate TTP-mediated mRNA turnover and functionally links the control of TTP-regulated mRNA stability to mTORC2 activity, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4QN22;E9PKY1;Q96H46;Q9H7V4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0031932 TORC2 complex",
        "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0090316 positive regulation of intracellular protein transport;GO:0001933 negative regulation of protein phosphorylation;GO:0034599 cellular response to oxidative stress;GO:0009968 negative regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q6MZQ0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TE99-1",
        "uniprot_id": [
            {
                "id": "PXYP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TE99",
                "type": "external"
            }
        ],
        "mass": 55240.0,
        "length": 480,
        "protein_name": "2-phosphoxylose phosphatase 1",
        "gene_name": "PXYLP1",
        "organism": "Human",
        "refseq_name": "2-phosphoxylose phosphatase 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001032249",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032249",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PXYLP1; ACPL2; HEL124; PRO706; XYLP",
        "gene_names_refseq": "ACPL2; HEL124; PXYLP1; XYLP",
        "protein_names_uniprotkb": "2-phosphoxylose phosphatase 1; 3.1.3.-; Acid phosphatase-like protein 2; Xylosyl phosphatase; epididymis luminal protein 124",
        "protein_names_refseq": "2-phosphoxylose phosphatase 1 isoform 1; acid phosphatase-like 2; acid phosphatase-like protein 2; epididymis luminal protein 124; xylosyl phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92370);  (R-HSA-1971475)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "10.1101/2023.09.13.557529;10473568;10506123;10842173;11099377;11237011;11551958;11877387;12522689;12975309;14993226;15294915;15461586;17194707;19473117;22810237;23656592;24425863;25521717;25892735;30459171;31844290;32161166;33968037;35051231;9506957;9892646",
        "class_list": "glycogene",
        "function": "Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This study describes the cloning of a human cDNA encoding a novel protein designated 2-phosphoxylose phosphatase capable of dephosphorylating this Xyl residue., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 536,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNF5;Q49AJ2;W0TR04",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016791 phosphatase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process;GO:1902730 positive regulation of proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q8TE99-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16769-1",
        "uniprot_id": [
            {
                "id": "QPCT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16769",
                "type": "external"
            }
        ],
        "mass": 40877.0,
        "length": 361,
        "protein_name": "Glutaminyl-peptide cyclotransferase",
        "gene_name": "QPCT",
        "organism": "Human",
        "refseq_name": "glutaminyl-peptide cyclotransferase precursor",
        "refseq_ac": [
            {
                "id": "NP_036545",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036545",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "QPCT",
        "gene_names_refseq": "GCT; QC; QPCT; sQC",
        "protein_names_uniprotkb": "Glutaminyl-peptide cyclotransferase; 2.3.2.5; EC; Glutaminyl cyclase; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; QC; sQC",
        "protein_names_refseq": "EC; glutaminyl cyclase; glutaminyl-peptide cyclotransferase precursor; glutaminyl-tRNA cyclotransferase; glutamyl cyclase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25797);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "37639587;10.1101/2023.09.13.557529;11237011;12196024;14522962;14680951;15063747;16135565;18072935;18486145;21288892;21671571;23090970;23481700;23650620;24190977;25645385;27600516;28514659;31844290;32157095;32488085;32938616;32983136;33043033;33968037;34036385;34171305;34309760;35051231;35494241;37060824;37074911;37381175;38253038;7999256;8692836",
        "class_list": "",
        "function": "A glutaminyl cyclase-catalyzed alpha-synuclein modification identified in human synucleinopathies., [RefSeq, PubMed]; Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression., [RefSeq, PubMed]; Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer., [RefSeq, PubMed]; Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure., [RefSeq, PubMed]; Human glutaminyl cyclase is a metal-dependent transferase, [RefSeq, PubMed]; QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis., [RefSeq, PubMed]; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16770;Q3KRG6;Q53TR4",
        "ec_number_list": [
            {
                "id": "1.8.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "2.4.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "5.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9",
                "type": "external"
            },
            {
                "id": "5.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-",
                "type": "external"
            },
            {
                "id": "3.4.23.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5",
                "type": "external"
            },
            {
                "id": "3.4.22.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52",
                "type": "external"
            },
            {
                "id": "3.4.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            },
            {
                "id": "1.13.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34",
                "type": "external"
            },
            {
                "id": "3.3.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6",
                "type": "external"
            },
            {
                "id": "3.4.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "4.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24",
                "type": "external"
            },
            {
                "id": "3.4.19.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1",
                "type": "external"
            },
            {
                "id": "5.3.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1",
                "type": "external"
            },
            {
                "id": "5.3.3.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            },
            {
                "id": "5.4.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11",
                "type": "external"
            },
            {
                "id": "5.4.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4",
                "type": "external"
            },
            {
                "id": "1.4.3.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22",
                "type": "external"
            },
            {
                "id": "1.4.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "3.4.24.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.5.4.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "5.4.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2",
                "type": "external"
            },
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1",
                "type": "external"
            },
            {
                "id": "2.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.5.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6",
                "type": "external"
            },
            {
                "id": "1.11.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24",
                "type": "external"
            },
            {
                "id": "3.2.1.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14",
                "type": "external"
            },
            {
                "id": "3.5.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.109",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.109",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
            },
            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "3.2.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18",
                "type": "external"
            },
            {
                "id": "2.1.1.348",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348",
                "type": "external"
            },
            {
                "id": "2.1.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.9",
                "type": "external"
            },
            {
                "id": "3.5.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.4.18.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
                "type": "external"
            },
            {
                "id": "3.2.1.166",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166",
                "type": "external"
            },
            {
                "id": "4.1.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016603 glutaminyl-peptide cyclotransferase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0070062 extracellular exosome;GO:1904813 ficolin-1-rich granule lumen;GO:0035580 specific granule lumen;GO:1904724 tertiary granule lumen",
        "go_biological_process": "GO:0036211 protein modification process;GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q16769-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WV60-1",
        "uniprot_id": [
            {
                "id": "PTCD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WV60",
                "type": "external"
            }
        ],
        "mass": 43968.0,
        "length": 388,
        "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial",
        "gene_name": "PTCD2",
        "organism": "Human",
        "refseq_name": "pentatricopeptide repeat-containing protein 2, mitochondrial isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001271332",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271332",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTCD2",
        "gene_names_refseq": "PTCD2",
        "protein_names_uniprotkb": "Pentatricopeptide repeat-containing protein 2, mitochondrial",
        "protein_names_refseq": "CTC-365E16.1; pentatricopeptide repeat-containing protein 2, mitochondrial isoform 2; pentatricopeptide repeat-containing protein 2, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79810)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;18729827;19664994;20877624;23186163;31844290;32938616;35051231;36430722",
        "class_list": "",
        "function": "Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z5D0;B7Z8L7;E9PFV7;Q6IA65;Q9H9R0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0007005 mitochondrion organization;GO:0050684 regulation of mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8WV60-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EV2-1",
        "uniprot_id": [
            {
                "id": "RBM33_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EV2",
                "type": "external"
            }
        ],
        "mass": 129986.0,
        "length": 1170,
        "protein_name": "RNA-binding protein 33",
        "gene_name": "RBM33",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 33",
        "refseq_ac": [
            {
                "id": "NP_444271",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444271",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM33; PRR8",
        "gene_names_refseq": "PRR8; RBM33",
        "protein_names_uniprotkb": "RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33",
        "protein_names_refseq": "RNA-binding protein 33; hypothetical protein MGC20460; proline rich 8; proline-rich protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:155435)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17081983;17924679;18318008;18452278;18669648;18767875;19007248;19651622;19664995;19690332;19691289;20058876;20068231;21406692;23186163;23481700;24129315;24275569;24715725;25576301;25645385;26154972;26992070;27846572;28228285;28446606;28832583;28904123;29237092;29242379;29393594;29557506;29632711;30192525;30315122;30379171;30620550;31492838;31844290;32157095;32357974;32387766;32502341;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33592498;33691108;33912179;33968037;34019948;34087483;34171305;34509645;35051231;35254053;35289036;35318648;35513511;35580925;35589130;36010968;36215666;36241641;36284347;37217939;37257451;37340703;38665916;39246182;39302247;39531497;39534244",
        "class_list": "",
        "function": "Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm., [RefSeq, PubMed]; RBM33 is a unique m[6]A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity., [RefSeq, PubMed]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D244;B5MC24;Q52LF5;Q75LN9;Q75ML5;Q9NSV0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0106222 lncRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q96EV2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UPR0-1",
        "uniprot_id": [
            {
                "id": "PLCL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UPR0",
                "type": "external"
            }
        ],
        "mass": 125866.0,
        "length": 1127,
        "protein_name": "Inactive phospholipase C-like protein 2",
        "gene_name": "PLCL2",
        "organism": "Human",
        "refseq_name": "inactive phospholipase C-like protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001137854",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137854",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLCL2; KIAA1092; PLCE2",
        "gene_names_refseq": "PLCE2; PLCL2",
        "protein_names_uniprotkb": "Inactive phospholipase C-like protein 2; PLC-L(2); PLC-L2; PLC-epsilon-2; Phospholipase C-L2; Phospholipase C-epsilon-2",
        "protein_names_refseq": "PLC-L(2); PLC-L2; PLC-epsilon-2; inactive phospholipase C-like protein 2 isoform 1; inactive phospholipase C-like protein 2; phospholipase C-L2; phospholipase C-epsilon-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23228)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "11237011;18669648;19690332;19898481;20068231;23186163;23481700;23783831;24275569;24715725;25505266;25576301;26154972;26992070;27600516;27862975;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29789417;30379171;30484775;30524438;31844290;31970634;32157095;32350084;32387766;32392189;32488085;32502341;32983136;33141586;33298915;33633747;33968037;34171305;34509645;34932366;35051231;35318648;35580925;36010968;36241641;36284347",
        "class_list": "",
        "function": "May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Two Novel SNPs in the PLCL2 Gene Associated with Large Artery Atherosclerotic Stroke Identified by Fine-Mapping., [RefSeq, PubMed]; [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5V4;Q8N498;Q9H8L0;Q9UFP9",
        "ec_number_list": [
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0050811 GABA receptor binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process;GO:0032228 regulation of synaptic transmission, GABAergic",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q9UPR0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55786-1",
        "uniprot_id": [
            {
                "id": "PSA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55786",
                "type": "external"
            }
        ],
        "mass": 103276.0,
        "length": 919,
        "protein_name": "Puromycin-sensitive aminopeptidase",
        "gene_name": "NPEPPS",
        "organism": "Human",
        "refseq_name": "puromycin-sensitive aminopeptidase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001317186",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317186",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPEPPS; PSA",
        "gene_names_refseq": "AAP-S; MP100; NPEPPS; PSA",
        "protein_names_uniprotkb": "Puromycin-sensitive aminopeptidase; 3.4.11.14; AAP-S; Cytosol alanyl aminopeptidase; PSA",
        "protein_names_refseq": "cytosol alanyl aminopeptidase; metalloproteinase MP100; puromycin-sensitive aminopeptidase isoform 2; puromycin-sensitive aminopeptidase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9520);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 136,
        "publication_id_list": "10329370;10978616;11062501;11237011;11350924;11435692;12646216;12729622;14734113;15224091;15224092;15571818;16595681;16849449;16954532;17154549;17318184;18446792;18662542;19028597;19352404;19452197;19489725;19851334;19874575;19917696;19940261;20068231;2261476;23481700;24715725;25342037;25418920;25576301;25645385;25880248;25892735;26078706;26154972;26768311;26811146;26992070;27543614;27600516;27920218;28063628;28218747;28228285;28467828;28649982;28832583;28834231;28855257;28860189;28904123;29242379;29314611;29317506;29331515;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30397120;30410026;30524438;30573663;30626607;30779550;30833945;31154438;31217245;31222486;31523044;31844290;31848261;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33043033;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34048566;34087483;34171305;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38665916;40596516;40914422;9048733;9380723;9668046",
        "class_list": "",
        "function": "Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese., [RefSeq, PubMed]; Cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis Publication Status: Online-Only, [RefSeq, PubMed]; MiR-614 inhibited cell invasion and proliferationa targeting PSA in lung cancer cells, PGCL3, [RefSeq, PubMed]; PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway., [RefSeq, PubMed]; This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z463;Q6P145;Q9NP16;Q9UEM2",
        "ec_number_list": [
            {
                "id": "3.4.14.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10",
                "type": "external"
            },
            {
                "id": "3.4.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
                "type": "external"
            },
            {
                "id": "3.4.11.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14",
                "type": "external"
            },
            {
                "id": "3.4.22.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40",
                "type": "external"
            },
            {
                "id": "3.4.11.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0016285 alanyl aminopeptidase activity;GO:0008237 metallopeptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0043171 peptide catabolic process;GO:0071456 cellular response to hypoxia;GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 13.9,
        "record_id": "P55786-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15067-1",
        "uniprot_id": [
            {
                "id": "PUR4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15067",
                "type": "external"
            }
        ],
        "mass": 144734.0,
        "length": 1338,
        "protein_name": "Phosphoribosylformylglycinamidine synthase",
        "gene_name": "PFAS",
        "organism": "Human",
        "refseq_name": "phosphoribosylformylglycinamidine synthase",
        "refseq_ac": [
            {
                "id": "NP_036525",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036525",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PFAS; KIAA0361",
        "gene_names_refseq": "FGAMS; FGAR-AT; FGARAT; GATD8; PFAS; PURL",
        "protein_names_uniprotkb": "Phosphoribosylformylglycinamidine synthase; 6.3.5.3; FGAM synthase; FGAMS; FGAR amidotransferase; FGAR-AT; Formylglycinamide ribonucleotide amidotransferase; Formylglycinamide ribotide amidotransferase; Phosphoribosylformylglycineamide amidotransferase",
        "protein_names_refseq": "FGAM synthase; FGAR amidotransferase; IKZF1/PFAS fusion; formylglycinamide ribonucleotide amidotransferase; formylglycinamide ribotide amidotransferase; formylglycinamide ribotide synthetase; phosphoribosylformylglycinamidine synthase; phosphoribosylformylglycineamide amidotransferase",
        "tax_id": 9606,
        "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:5198);  (R-HSA-73817)",
        "pathway_count": 2,
        "publication_count": 116,
        "publication_id_list": "10548741;10958654;11096114;11237011;11381136;12450384;14529546;15786719;1592113;17081983;17224163;18388293;18609073;19651622;1967654;19690332;20068231;21320556;21406692;2147474;2183217;21960835;23186163;23301498;23481700;24715725;25418920;25576301;26929215;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28855257;28904123;29242379;29337348;29393594;29437277;29557506;29632046;29632711;29769354;30059200;30192525;30315122;30410026;30429286;30484775;30987822;31154438;31217245;31844290;31848261;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32485148;32488085;32502341;32870666;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33968037;33981976;34171305;34185709;34357683;34509645;34561969;34725712;34932366;35051231;35138101;35251023;35318648;35580925;35705054;36010968;36215666;36241641;37228185;37938771;38665916;40307207;40914422;4348202;4726295;762062;7706277;7903306;8089153;8110788;8366112;8380692;8567683",
        "class_list": "",
        "function": "A total of 429 proteins are newly identified to interact with PFAS. PFAS interacts with CAD, CCT2, PRDX1, and PHGDH., [RefSeq, PubMed]; ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis., [RefSeq, PubMed]; NSUN2-mediated m[5] C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression., [RefSeq, PubMed]; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate., [UniProtKB, PubMed]; Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]., [RefSeq]; Study observed FGAMS as distinct puncta throughout neuronal processes, where it co-localized with neurofilament heavy chain, tubulin, and mitochondria. Data provide insight into potential purine biosynthetic mechanisms utilized within neurons during homeostasis as well as viral infection., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8V8",
        "ec_number_list": [
            {
                "id": "6.3.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004642 phosphoribosylformylglycinamidine synthase activity;GO:0016874 ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0009168 purine ribonucleoside monophosphate biosynthetic process;GO:0009410 response to xenobiotic stimulus;GO:0006541 glutamine metabolic process;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "O15067-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9QC07-1",
        "uniprot_id": [
            {
                "id": "POK18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9QC07",
                "type": "external"
            }
        ],
        "mass": 91948.0,
        "length": 812,
        "protein_name": "Endogenous retrovirus group K member 18 Pol protein",
        "gene_name": "ERVK-18",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "ERVK-18",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 18 Pol protein; HERV-K(C1a) Pol protein; HERV-K110 Pol protein; HERV-K18 Pol protein; HERV-K_1q23.3 provirus ancestral Pol protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 12,
        "publication_id_list": "10496080;10516026;11672540;11672541;11776384;11841850;11982593;12629516;14988274;23481700;9244304;9778243",
        "class_list": "",
        "function": "Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution., [UniProtKB]; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This envelope protein has superantigenic properties., [UniProtKB]; Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution., [UniProtKB]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6QAI9;Q96PI5",
        "ec_number_list": [
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "2.7.7.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "3.1.26.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4",
                "type": "external"
            },
            {
                "id": "3.4.23.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.50",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.7.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006261 DNA-templated DNA replication;GO:0015074 DNA integration;GO:0006508 proteolysis;GO:0075523 viral translational frameshifting",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9QC07-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P49903-1",
        "uniprot_id": [
            {
                "id": "SPS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P49903",
                "type": "external"
            }
        ],
        "mass": 42911.0,
        "length": 392,
        "protein_name": "Zincore component SEPHS1",
        "gene_name": "SEPHS1",
        "organism": "Human",
        "refseq_name": "zincore component SEPHS1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001182531",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182531",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEPHS1; SELD; SPS1; SPS",
        "gene_names_refseq": "SELD; SEPHS1; SPS1; SPS; VERBRAS2",
        "protein_names_uniprotkb": "Zincore component SEPHS1; 2.7.9.3; Selenide, water dikinase 1; Selenium donor protein 1; Selenophosphate synthase 1",
        "protein_names_refseq": "selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1; selenophosphate synthetase 1 +E9a; selenophosphate synthetase 1 +E9; selenophosphate synthetase 1 delta E2; selenophosphate synthetase 1 delta E8; selenophosphate synthetase 1 major; zincore component SEPHS1 isoform 2; zincore component SEPHS1",
        "tax_id": 9606,
        "disease": "Ververi-Brady syndrome 2 (MONDO:MONDO:0980726)",
        "pathway": " (hsa:22929)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "11237011;15534230;16385451;16508009;19413330;19477186;20068231;20471958;24029068;25576301;26758079;26992070;27862975;28218747;28228285;28414460;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29437277;29485866;29557506;29786170;30315122;30410026;30429286;30484775;30833945;31154438;31217245;31607477;31844290;31848261;32157095;32350084;32357974;32387766;32897882;33298915;33912179;33936100;33968037;34019948;34087483;34357683;34932366;35051231;35140209;35318648;35580925;36215666;36241641;38531365;40608935;7665581",
        "class_list": "",
        "function": "Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (PubMed:40608935). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (PubMed:40608935). Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability (PubMed:40608935). Plays an essential role in redox homeostasis (PubMed:31607477). May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP (PubMed:7665581). Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role (PubMed:15534230). Required for cardiac differentiation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; De novo missense variants in exon 9 of SEPHS1 cause a neurodevelopmental condition with developmental delay, poor growth, hypotonia, and dysmorphic features. Erratum:[Am J Hum Genet. 2024 Jun 6;111(6):1240. doi: 10.1016/j.ajhg.2024.05.004. PMID: 38749428], [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; SEPHS1 expression is high in undifferentiated embryonic stem cells.SEPHS1 expression is required to obtain pluripotency.SEPHS1 plays a role in the embryonic stem cell survival via reactive oxygen species signaling and apoptosis., [RefSeq, PubMed]; Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; The Sps1-encoded enzyme depends on a selenium salvage system that recycles l-selenocysteine, whereas the Sps2 enzyme can function with a selenite assimilation system, [RefSeq, PubMed]; This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWK0;D3DRS9;D6PSQ9;Q5T5U8;Q5T5U9;Q9BVT4",
        "ec_number_list": [
            {
                "id": "2.7.9.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005694 chromosome",
        "go_biological_process": "GO:0036211 protein modification process;GO:0016260 selenocysteine biosynthetic process;GO:0006351 DNA-templated transcription;GO:0045454 cell redox homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "P49903-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UMR5-1",
        "uniprot_id": [
            {
                "id": "PPT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UMR5",
                "type": "external"
            }
        ],
        "mass": 34225.0,
        "length": 302,
        "protein_name": "Lysosomal thioesterase PPT2",
        "gene_name": "PPT2-EGFL8; PPT2",
        "organism": "Human",
        "refseq_name": "lysosomal thioesterase PPT2 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001191032",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191032",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPT2-EGFL8; PPT2; PPT2-EGFL8",
        "gene_names_refseq": "C6orf8; G14; PPT-2; PPT2",
        "protein_names_uniprotkb": "Lysosomal thioesterase PPT2; 3.1.2.2; PPT-2; Palmitoyl-protein thioesterase 2; S-thioesterase G14",
        "protein_names_refseq": "S-thioesterase G14; VE-statin2; lysosomal thioesterase PPT2 isoform a precursor; lysosomal thioesterase PPT2; palmitoyl-protein hydrolase 2",
        "tax_id": 9606,
        "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)",
        "pathway": " (hsa:9374);  (R-HSA-75105)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;10051407;10229681;10417332;11230166;11237011;12689621;12855696;13651131;1371749;14656967;14759258;15610069;15668256;15907797;16854592;17898086;17978863;18455495;19571038;20470824;22102020;22465940;23700546;23932781;24190977;24286864;24387323;25203508;25645385;27892461;28467828;28904123;29242379;29314611;33592498;33912179;34019948;34089345;34357683;35051231;35251023;37074911;3805044;38665916;5810867;627544;7567999;7732023;7901201;7909540;7916016;9341199",
        "class_list": "",
        "function": "Catalytically inactive due to lack of active site His-283., [UniProtKB, PubMed]; Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2., [RefSeq, PubMed]; This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]., [RefSeq]; We identified that PPT2 on chromosome 6p21 is associated with loss of lung function in the Korean population., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2ABC9;A2ABD1;A2ARM7;A2BFH7;A2BFH9;A2BFI2;A8K9L4;B0S868;G8JLE1;O14799;Q0P6K0;Q5JP13;Q5JP14;Q5JQF0;Q5SSX4;Q5SSX5;Q5SSX6;Q5STJ4;Q5STJ5;Q5STJ6;Q6FI80;Q99945",
        "ec_number_list": [
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.5.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016790 thiolester hydrolase activity;GO:0098599 palmitoyl hydrolase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0070062 extracellular exosome;GO:0005764 lysosome;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0046949 fatty-acyl-CoA biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q9UMR5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NA58-1",
        "uniprot_id": [
            {
                "id": "PNDC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NA58",
                "type": "external"
            }
        ],
        "mass": 60124.0,
        "length": 520,
        "protein_name": "Poly(A)-specific ribonuclease PNLDC1",
        "gene_name": "PNLDC1",
        "organism": "Human",
        "refseq_name": "poly(A)-specific ribonuclease PNLDC1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001258791",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258791",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNLDC1",
        "gene_names_refseq": "HsPNLDC1; PNLDC1; SPGF57; Trimmer",
        "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PNLDC1; 3.1.13.4; HsPNLDC1; PARN-like domain-containing protein 1; Poly(A)-specific ribonuclease domain-containing protein 1",
        "protein_names_refseq": "PARN like, ribonuclease domain containing 1; poly(A)-specific ribonuclease (PARN)-like domain containing 1; poly(A)-specific ribonuclease PARN-like domain-containing protein 1; poly(A)-specific ribonuclease PNLDC1 isoform 1; poly(A)-specific ribonuclease PNLDC1; poly(A)-specific ribonuclease domain-containing protein 1",
        "tax_id": 9606,
        "disease": "spermatogenic failure 57 (Disease Ontology:DOID:0112338)",
        "pathway": " (hsa:154197)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;24715725;27260655;27515512;27600516;30379171;31154438;31844290;33633747;34347949;35361267;37282384",
        "class_list": "",
        "function": "3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed:34347949)., [UniProtKB, PubMed, UniProtKB, PubMed]; A risk model of gene signatures for predicting platinum response and survival in ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The role of homozygous LOF variant of the PNLDC1 gene in oligo-astheno-teratozoospermia (OAT) and male infertility., [RefSeq, PubMed]; We describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder. Using whole-genome sequencing, we delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TAP7;Q8N7X5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0034587 piRNA processing;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:1990431 priRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8NA58-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20472-1",
        "uniprot_id": [
            {
                "id": "PRVA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20472",
                "type": "external"
            }
        ],
        "mass": 12059.0,
        "length": 110,
        "protein_name": "Parvalbumin alpha",
        "gene_name": "PVALB",
        "organism": "Human",
        "refseq_name": "parvalbumin alpha",
        "refseq_ac": [
            {
                "id": "NP_001302461",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001302461",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PVALB",
        "gene_names_refseq": "D22S749; PVALB",
        "protein_names_uniprotkb": "Parvalbumin alpha; Alpha-PV; Alpha-parvalbumin",
        "protein_names_refseq": "alpha-PV; alpha-parvalbumin; parvalbumin alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5816);  (R-HSA-8986944)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "10036163;11237011;15122922;18477386;2614829;26843422;28683304;29557506;33386125;34087483;34439824;37073488;38412332;39584689;8354278",
        "class_list": "",
        "function": "Elevations in the Mitochondrial Matrix Protein Cyclophilin D Correlate With Reduced Parvalbumin Expression in the Prefrontal Cortex of Patients With Schizophrenia., [RefSeq, PubMed]; In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (PubMed:15122922, PubMed:39584689)., [UniProtKB, PubMed, PubMed, UniProtKB]; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Propofol sedation-induced alterations in brain connectivity reflect parvalbumin interneurone distribution in human cerebral cortex., [RefSeq, PubMed]; Strontium Binding to alpha-Parvalbumin, a Canonical Calcium-Binding Protein of the ''EF-Hand'' Family. Publication Status: Online-Only, [RefSeq, PubMed]; The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons., [RefSeq, PubMed]; The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4H7;P78378;Q4VB78;Q5R3Q9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0045202 synapse",
        "go_biological_process": "GO:0090075 relaxation of muscle;GO:0098976 excitatory chemical synaptic transmission;GO:0010467 gene expression;GO:0098977 inhibitory chemical synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P20472-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4G2-1",
        "uniprot_id": [
            {
                "id": "PKHM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4G2",
                "type": "external"
            }
        ],
        "mass": 117443.0,
        "length": 1056,
        "protein_name": "Pleckstrin homology domain-containing family M member 1",
        "gene_name": "PLEKHM1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family M member 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055613",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055613",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHM1; KIAA0356",
        "gene_names_refseq": "AP162; B2; OPTA3; OPTB6; PLEKHM1",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 1; 162 kDa adapter protein; AP162; PH domain-containing family M member 1",
        "protein_names_refseq": "162 kDa adapter protein; PH domain-containing family M member 1; pleckstrin homology domain containing, family M (with RUN domain) member 1; pleckstrin homology domain-containing family M member 1 isoform 1; pleckstrin homology domain-containing family M member 1",
        "tax_id": 9606,
        "disease": "autosomal recessive osteopetrosis 6 (Disease Ontology:DOID:0110945); osteopetrosis (Disease Ontology:DOID:13533); osteopetrosis, autosomal dominant 3 (MONDO:MONDO:0020848)",
        "pathway": " (hsa:9842)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;12820725;17404618;17997709;20068231;20943950;23186163;24366607;24714562;24715725;25498145;25500191;25576301;25880248;26992070;27291868;27846572;27920218;28218747;28325809;28832583;28834231;28904123;29242379;29351928;29437277;29557506;30410026;30429286;31844290;32157095;32357974;32387766;32502341;32938616;32983136;33298915;33452816;33537174;33592498;33912179;33968037;33981976;34171305;34405274;35494241;35580925;35981699;36010968;37938771;38797732",
        "class_list": "",
        "function": "(Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7., [UniProtKB, PubMed]; Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts, [RefSeq, PubMed]; Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking., [RefSeq, PubMed]; PLEKHM1 is a novel gene implicated in the development of osteopetrosis, with a putative critical function in vesicular transport in the osteoclast., [RefSeq, PubMed]; Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase, [RefSeq, PubMed]; The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways., [RefSeq, PubMed]; The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]; These data indicate that B2 is a novel, ubiquitously expressed protein with a putative adapter function. The protein has been named AP162., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P2R5;Q8TEL9;Q9NPP5;Q9NYA0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005764 lysosome;GO:0031902 late endosome membrane;GO:0044754 autolysosome;GO:0120281 autolysosome membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0045780 positive regulation of bone resorption;GO:0032418 lysosome localization;GO:1902774 late endosome to lysosome transport;GO:1900029 positive regulation of ruffle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9Y4G2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2H5-1",
        "uniprot_id": [
            {
                "id": "PKHA6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2H5",
                "type": "external"
            }
        ],
        "mass": 117128.0,
        "length": 1048,
        "protein_name": "Pleckstrin homology domain-containing family A member 6",
        "gene_name": "PLEKHA6",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family A member 6",
        "refseq_ac": [
            {
                "id": "NP_055750",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055750",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHA6; KIAA0969; PEPP3",
        "gene_names_refseq": "PEPP-3; PEPP3; PLEKHA6",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 6; PEPP-3; PH domain-containing family A member 6; Phosphoinositol 3-phosphate-binding protein 3",
        "protein_names_refseq": "PH domain-containing family A member 6; phosphoinositol 3-phosphate-binding protein 3; pleckstrin homology domain-containing family A member 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22874);  (R-HSA-1660499)",
        "pathway_count": 2,
        "publication_count": 116,
        "publication_id_list": "10.1101/2023.09.13.557529;10194451;10224048;10555148;10559940;10593988;10753883;10805725;10822173;11001876;11084340;11237011;11279162;11302699;11349134;11604140;11676921;11733541;11877430;11923287;12101241;12118066;12324459;12422219;12536145;12646134;12808147;12847086;14516276;14617813;14660569;15080793;15107860;15135396;15464023;15716355;15797027;15840652;15951569;16154996;16399794;16476736;16522682;16914545;16964243;16979564;17008356;17016520;17245604;17389395;17651088;18093523;18452278;18669648;18753295;19038970;19562805;19896968;20166139;20534812;21204784;22037487;22647598;23186163;23519112;23758345;24275569;24576533;24715725;25495341;25576301;28510447;29393594;29557506;30379171;30429286;31373491;31844290;32157095;32387766;32938616;32983136;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34613798;34932366;35051231;35318648;35580925;36284347;38253038;7608176;7624799;8681945;8723348;8769125;9094719;9113989;9211928;9286278;9295334;9367159;9428629;9514948;9516481;9524259;9593664;9660759;9660833;9811831;9830063",
        "class_list": "",
        "function": "PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis., [RefSeq, PubMed]; This study demonistrated that PLEKHA6 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients. Erratum:[Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 3;58:106. Meyerwas, Sebastian [added]], [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 29,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MD51;Q5VTI6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "Q9Y2H5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UMZ3-1",
        "uniprot_id": [
            {
                "id": "PTPRQ_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UMZ3",
                "type": "external"
            }
        ],
        "mass": 260924.0,
        "length": 2332,
        "protein_name": "Phosphatidylinositol phosphatase PTPRQ",
        "gene_name": "PTPRQ",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PTPRQ",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Phosphatidylinositol phosphatase PTPRQ; 3.1.3.67; 3.1.3.86; 3.1.3.95; PTP-RQ; R-PTP-Q; Receptor-type tyrosine-protein phosphatase Q",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 73 (Disease Ontology:DOID:0080269); autosomal recessive nonsyndromic deafness 84A (Disease Ontology:DOID:0110529)",
        "pathway": " (hsa:374462)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;12837292;19351528;20346435;20472657;23897475;24715725;29309402;29557506;31844290;32488085;32502341;32938616;33091337;33392160;33968037;35051231;35580925",
        "class_list": "",
        "function": "Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3 (PubMed:23897475). Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring (PubMed:23897475). Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear (By similarity). Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells (PubMed:19351528). Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function (PubMed:20472657, PubMed:29309402). May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 10,
        "predicted_n_glycosites": 10,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.95",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity",
        "go_cellular_component": "GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0120044 stereocilium base;GO:0032420 stereocilium",
        "go_biological_process": "GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0045598 regulation of fat cell differentiation;GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q9UMZ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IXY8-1",
        "uniprot_id": [
            {
                "id": "PPIL6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IXY8",
                "type": "external"
            }
        ],
        "mass": 35228.0,
        "length": 311,
        "protein_name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6",
        "gene_name": "PPIL6",
        "organism": "Human",
        "refseq_name": "probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001104768",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104768",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPIL6",
        "gene_names_refseq": "PPIL6; PPIase; RSPH12; bA425D10.6; dJ919F19.1",
        "protein_names_uniprotkb": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6; Cyclophilin-like protein PPIL6; PPIase; Rotamase PPIL6",
        "protein_names_refseq": "cyclophilin-like protein PPIL6; peptidyl-prolyl cis-trans isomerase-like 6; peptidylprolyl isomerase (cyclophilin)-like 6; probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 2; probable inactive peptidyl-prolyl cis-trans isomerase-like 6; problable inactive peptidyl-prolyl cis-trans isomerase-like 6; radial spoke 12 homolog; rotamase PPIL6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285755);  (R-HSA-9918481)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "11237011;11747608;14519844;14762106;15084397;20676357;21911577;25880248;26092250;27108190;28218747;29902443;30599162;31154438;33177556;33981976;35051231;35215846",
        "class_list": "",
        "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB]; Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9NIU0;A9NIU9;E7EX15",
        "ec_number_list": [
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q8IXY8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22102-1",
        "uniprot_id": [
            {
                "id": "PUR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22102",
                "type": "external"
            }
        ],
        "mass": 107767.0,
        "length": 1010,
        "protein_name": "Trifunctional purine biosynthetic protein adenosine-3",
        "gene_name": "GART",
        "organism": "Human",
        "refseq_name": "trifunctional purine biosynthetic protein adenosine-3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000810",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000810",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GART; PGFT; PRGS",
        "gene_names_refseq": "AIRS; GARS; GARTF; GART; PAIS; PGFT; PRGS",
        "protein_names_uniprotkb": "Trifunctional purine biosynthetic protein adenosine-3; 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase",
        "protein_names_refseq": "GAR transformylase; GARS-AIRS-GART; glycinamide ribonucleotide formyltransferase; glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase; trifunctional purine biosynthetic protein adenosine-3 isoform 1; trifunctional purine biosynthetic protein adenosine-3",
        "tax_id": 9606,
        "disease": "Down syndrome (Disease Ontology:DOID:14250)",
        "pathway": " (hsa:2618);  (R-HSA-73817)",
        "pathway_count": 2,
        "publication_count": 147,
        "publication_id_list": "10958654;11096114;11237011;11381136;12450384;12755606;14529546;14654843;15592455;15786719;1592113;16026156;16408927;17224163;18083107;18388293;18609073;19608861;1967654;20068231;20631005;21320556;2147474;2183217;21960835;22544926;22645359;23186163;23301498;23481700;24366607;24714562;24715725;25502872;25576301;25645385;25810538;26154972;26375851;26992070;27600516;27659940;27718035;27846572;27862975;27920218;28218747;28228285;28446606;28467828;28510447;28514659;28832583;28834231;28904123;29242379;29314611;29437277;29493099;29508533;29557506;29632711;29786170;29789417;30192525;30315122;30397120;30410026;30429286;30484775;30524438;30626607;30779550;30833945;31020640;31217245;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33141586;33214551;33298915;33537174;33592498;33633747;33691108;33717175;33912179;33933170;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34433824;34509645;34725712;34932366;35051231;35132862;35138101;35154160;35251023;35318648;35434822;35494241;35561310;35580925;36010968;36215666;36241641;36284347;37439412;37938771;38665916;39302247;40307207;40914422;4348202;4726295;762062;7706277;7903306;8089153;8110788;8366112;8380692;8567683;9224613",
        "class_list": "",
        "function": "GART Functions as a Novel Methyltransferase in the RUVBL1/beta-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer., [RefSeq, PubMed]; GART expression is up-regulated in patients with active colitis., [RefSeq, PubMed]; The minor A allele of rs7279549 of GART is a functional risk factor for congenital heart disease in Shandong population., [RefSeq, PubMed]; The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; The transcriptome profile of human trisomy 21 blood cells. Publication Status: Online-Only, [RefSeq, PubMed]; Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K945;A8KA32;D3DSF3;D3DSF4;O14659;Q52M77",
        "ec_number_list": [
            {
                "id": "2.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.2",
                "type": "external"
            },
            {
                "id": "6.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.3.1",
                "type": "external"
            },
            {
                "id": "6.3.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.13",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644 phosphoribosylglycinamide formyltransferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0003360 brainstem development;GO:0021987 cerebral cortex development;GO:0009168 purine ribonucleoside monophosphate biosynthetic process;GO:0021549 cerebellum development;GO:0006177 GMP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "P22102-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P1Y6-1",
        "uniprot_id": [
            {
                "id": "PHRF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P1Y6",
                "type": "external"
            }
        ],
        "mass": 178666.0,
        "length": 1649,
        "protein_name": "PHD and RING finger domain-containing protein 1",
        "gene_name": "PHRF1",
        "organism": "Human",
        "refseq_name": "PHD and RING finger domain-containing protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001273510",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273510",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHRF1; KIAA1542",
        "gene_names_refseq": "PHRF1; PPP1R125; RNF221",
        "protein_names_uniprotkb": "PHD and RING finger domain-containing protein 1",
        "protein_names_refseq": "CTD-binding SR-like protein rA9; PHD and RING finger domain-containing protein 1 isoform 1; PHD and RING finger domain-containing protein 1; protein phosphatase 1, regulatory subunit 125",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57661)",
        "pathway_count": 1,
        "publication_count": 81,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17081983;18204446;18669648;19690332;20068231;20112359;20848568;20881011;21406692;22645359;22869377;23186163;23301498;23481700;24275569;24714562;24715725;25576301;26154972;26375851;26811146;26992070;27600516;27608840;27846572;27920218;28228285;28514659;28657654;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632046;29632711;29786170;30315122;30379171;30524438;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32360246;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;35051231;35318648;35494241;35580925;36284347;36581221;37938771;38030167;38253038;38665916",
        "class_list": "",
        "function": "Downregulation of a putative tumor suppressor gene PHRF1 in gastric and colorectal cancers., [RefSeq, PubMed]; Observational study and meta-analysis of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of PHRF1 attenuated the proliferation and tumorigenicity of non-small cell lung cancer cell lines., [RefSeq, PubMed]; PHRF1 Promotes Cell Invasion by Modulating SOX4 Expression in Colorectal Cancer HCT116-p53[-/-] Cells., [RefSeq, PubMed]; Study presents four new regions having genetic associations with systemic lupus erythematosus in women of European descent: ITGAM, KIAA1542, PXK and rs10798269 GeneRIF: Genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8W1;B7ZM64;B9EGP0;C9JS82;Q6PJP2;Q8IVY2;Q8N2Y7;Q9BSM2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070063 RNA polymerase binding",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9P1Y6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P06737-1",
        "uniprot_id": [
            {
                "id": "PYGL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P06737",
                "type": "external"
            }
        ],
        "mass": 97149.0,
        "length": 847,
        "protein_name": "Glycogen phosphorylase, liver form",
        "gene_name": "PYGL",
        "organism": "Human",
        "refseq_name": "glycogen phosphorylase, liver form isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001157412",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157412",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PYGL",
        "gene_names_refseq": "GSD6; PYGL",
        "protein_names_uniprotkb": "Glycogen phosphorylase, liver form; 2.4.1.1",
        "protein_names_refseq": "glycogen phosphorylase, liver form isoform 2; glycogen phosphorylase, liver form; phosphorylase, glycogen, liver",
        "tax_id": 9606,
        "disease": "glycogen storage disease (Disease Ontology:DOID:2747); glycogen storage disease VI (Disease Ontology:DOID:2754); lactic acidosis (Disease Ontology:DOID:3650)",
        "pathway": " (hsa:5836);  (R-HSA-6798695);  (R-HSA-70221)",
        "pathway_count": 3,
        "publication_count": 110,
        "publication_id_list": "10.1101/2023.09.13.557529;10487978;10949035;10980448;11237011;12204691;12604216;12825073;12930917;13115432;15118078;17081983;18083107;18323634;21767668;22225877;23650620;24275569;24714562;24715725;25576301;25645385;26154972;2667896;26758079;26992070;27600516;27846572;27862975;28218747;28228285;28514659;2877458;28832583;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29557506;2961257;29786170;30397120;30429286;30484775;3049072;30779550;30784271;30833945;31217245;31222486;31844290;31848261;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33123756;33141586;33214551;33392160;33537174;33592498;33633747;33968037;33981976;34019948;34078123;34087483;34171305;34357683;34405274;34509645;34516362;34675331;34939084;35037470;35051231;3509980;35138101;35251023;35580925;35611851;36010968;36215666;36241641;36284347;37938771;4829444;5264799;5461220;7847371;7902568;8420990;8692836;8755644;8896567;9504428;9529348;9536091;9691087",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of PYGL as a key prognostic gene of glioma by integrated bioinformatics analysis., [RefSeq, PubMed]; Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis., [RefSeq, PubMed]; MiR-155-5p regulates hypoxia-induced pulmonary artery smooth muscle cell function by targeting PYGL., [RefSeq, PubMed]; This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1087,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDQ4;B4DUB7;F5H816;O60567;O60752;O60913;Q501V9;Q641R5;Q96G82",
        "ec_number_list": [
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35",
                "type": "external"
            },
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
                "type": "external"
            },
            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
                "type": "external"
            },
            {
                "id": "2.4.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "5.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9",
                "type": "external"
            },
            {
                "id": "5.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-",
                "type": "external"
            },
            {
                "id": "3.4.23.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5",
                "type": "external"
            },
            {
                "id": "3.4.22.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52",
                "type": "external"
            },
            {
                "id": "2.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            },
            {
                "id": "1.13.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34",
                "type": "external"
            },
            {
                "id": "3.3.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6",
                "type": "external"
            },
            {
                "id": "3.4.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "4.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24",
                "type": "external"
            },
            {
                "id": "3.4.19.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1",
                "type": "external"
            },
            {
                "id": "5.3.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1",
                "type": "external"
            },
            {
                "id": "5.3.3.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "2.7.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11",
                "type": "external"
            },
            {
                "id": "5.4.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11",
                "type": "external"
            },
            {
                "id": "5.4.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "3.5.4.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5",
                "type": "external"
            },
            {
                "id": "5.4.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1",
                "type": "external"
            },
            {
                "id": "2.7.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.5.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6",
                "type": "external"
            },
            {
                "id": "1.11.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.5.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.109",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.109",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
                "type": "external"
            },
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.4.18.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
                "type": "external"
            },
            {
                "id": "4.1.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019842 vitamin binding;GO:0005524 ATP binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016208 AMP binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034774 secretory granule lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0042593 glucose homeostasis;GO:0005980 glycogen catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "P06737-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100010000001.010.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43351-1",
        "uniprot_id": [
            {
                "id": "RAD52_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43351",
                "type": "external"
            }
        ],
        "mass": 46169.0,
        "length": 418,
        "protein_name": "DNA repair protein RAD52 homolog",
        "gene_name": "RAD52",
        "organism": "Human",
        "refseq_name": "DNA repair protein RAD52 homolog isoform a",
        "refseq_ac": [
            {
                "id": "NP_001284348",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284348",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAD52",
        "gene_names_refseq": "RAD52",
        "protein_names_uniprotkb": "DNA repair protein RAD52 homolog",
        "protein_names_refseq": "DNA repair protein RAD52 homolog isoform a; RAD52 homolog, DNA repair protein; recombination protein RAD52; rhabdomyosarcoma antigen MU-RMS-40.23",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); salivary gland carcinoma (Disease Ontology:DOID:0050904); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)",
        "pathway": " (hsa:5893);  (R-HSA-3108214);  (R-HSA-5685938);  (R-HSA-5685939)",
        "pathway_count": 4,
        "publication_count": 124,
        "publication_id_list": "10212258;10438626;10574707;10673031;10744977;10921897;11237011;11340072;11440997;11571269;11698410;11792325;11889051;12139939;12191481;12226092;12370410;12379650;12750383;14734547;15135726;15175327;15355988;15485900;15561706;15608651;15823533;15829507;15940266;15959518;16012167;16030353;16150497;16478998;16608850;16626738;16688858;16810316;17525332;17693435;17962301;18539610;18541667;18625722;18691969;18691976;18708356;18757400;19092295;19287951;19357644;19596686;19622798;19664995;19706679;19779455;19956565;20016594;20016603;20190268;20483915;20647759;20705237;20965415;21098080;21147198;21284855;21550342;21804533;21816818;22508508;22635276;22661230;22751501;23750026;23871147;24027577;24782567;25114211;25201414;25218447;25576301;25642960;25642963;25643323;25789972;28832583;29133916;29242379;29393594;29493099;29632046;29786170;30410026;30429286;31400850;31585101;31844290;31998317;32093728;32157095;32983136;33592498;33981976;34616022;34932366;35051231;35494241;38081641;38625790;38658755;39117045;39237529;7526206;7774919;7797537;8003475;8702565;9214649;9412458;9452416;9756909;9837724;9885291",
        "class_list": "",
        "function": "A glimpse into the hidden world of the flexible C-terminal protein binding domains of human RAD52., [RefSeq, PubMed]; Human RAD52 stimulates the RAD51-mediated homology search. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanism of single-stranded DNA annealing by RAD52-RPA complex., [RefSeq, PubMed]; RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability. Publication Status: Online-Only, [RefSeq, PubMed]; RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells., [RefSeq, PubMed]; The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13205;Q9Y5T7;Q9Y5T8;Q9Y5T9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0003697 single-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006312 mitotic recombination;GO:2000819 regulation of nucleotide-excision repair;GO:0045002 double-strand break repair via single-strand annealing;GO:0006310 DNA recombination;GO:0006302 double-strand break repair",
        "synthesized_glycan_count": 0,
        "hit_score": 12.5,
        "record_id": "P43351-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P53805-1",
        "uniprot_id": [
            {
                "id": "RCAN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P53805",
                "type": "external"
            }
        ],
        "mass": 28079.0,
        "length": 252,
        "protein_name": "Calcipressin-1",
        "gene_name": "RCAN1",
        "organism": "Human",
        "refseq_name": "calcipressin-1 isoform d",
        "refseq_ac": [
            {
                "id": "NP_001272318",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272318",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RCAN1; ADAPT78; CSP1; DSC1; DSCR1",
        "gene_names_refseq": "ADAPT78; CSP1; DSCR1; MCIP1; RCAN1",
        "protein_names_uniprotkb": "Calcipressin-1; Adapt78; Down syndrome critical region protein 1; MCIP1; Myocyte-enriched calcineurin-interacting protein 1; Regulator of calcineurin 1",
        "protein_names_refseq": "Down syndrome candidate region 1; Down syndrome critical region gene 1; calcipressin-1 isoform d; calcipressin-1; calcium and oxidant-inducible mRNA; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250)",
        "pathway": " (hsa:1827)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "10861295;11237011;12063245;12809556;15935327;16126726;19413330;19651622;20068231;21965663;25892735;26811146;26992070;27600516;27862975;27920218;28228285;29393594;29632046;29769354;29786170;30429286;30484775;31154438;31844290;32157095;32161166;32938616;32983136;33592498;34561969;35051231;35580925;36010968;36215666;36241641;37051697;37918583;39053690;39192218;8595418;9325060",
        "class_list": "",
        "function": "CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma. Erratum:[Pharmacol Res. 2024 Jan;199:107021. doi: 10.1016/j.phrs.2023.107021. PMID: 38042685], [RefSeq, PubMed]; Identification of RCAN1's role in hepatocellular carcinoma using single-cell analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RCAN1 interacts with the catalytic subunit (calcineurin A) of the phosphatase calcineurin, [RefSeq, PubMed]; Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy., [RefSeq, PubMed]; The RCAN1.4 Metastasis Suppressor Is Hypermethylated at Intron 1 in Thyroid Cancer., [RefSeq, PubMed]; The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSF9;O00582;O00583;Q53XT0;Q6IBC6;Q7Z555;Q96R03;Q9BU69;Q9UF15;Q9UME4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0004864 protein phosphatase inhibitor activity;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0009612 response to mechanical stimulus;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0043627 response to estrogen;GO:0051151 negative regulation of smooth muscle cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "P53805-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6X0-1",
        "uniprot_id": [
            {
                "id": "SETBP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6X0",
                "type": "external"
            }
        ],
        "mass": 175008.0,
        "length": 1596,
        "protein_name": "SET-binding protein",
        "gene_name": "SETBP1",
        "organism": "Human",
        "refseq_name": "SET-binding protein isoform b",
        "refseq_ac": [
            {
                "id": "NP_001123582",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123582",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SETBP1; KIAA0437",
        "gene_names_refseq": "MRD29; SEB; SETBP1",
        "protein_names_uniprotkb": "SET-binding protein; SEB",
        "protein_names_refseq": "SET-binding protein isoform b; SET-binding protein",
        "tax_id": 9606,
        "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 29 (Disease Ontology:DOID:0070059); Schinzel Giedion syndrome (Disease Ontology:DOID:0070509); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:26040)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11231286;11237011;16582916;16959974;20436468;23222956;23481700;23628959;23648668;23832011;23832012;23889083;24854193;25217958;27869121;28904123;29242379;29493099;29508533;29557506;29632711;30379171;30429286;31092671;31154438;31844290;31848261;32157095;32161166;32938616;32983136;33592498;33968037;35051231;36228153;38165902;38194688;38520002;38923504",
        "class_list": "",
        "function": "Correction of X-linked chronic granulomatous disease by gene therapy was augmented by insertional activation of SETBP1., [RefSeq, PubMed]; First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis. Erratum:[Blood. 2024 Jun 27;143(26):2810. doi: 10.1182/blood.2024025290. PMID: 38935362], [RefSeq, PubMed]; SETBP1 haploinsufficiency and related disorders clinical and neurobehavioral phenotype study., [RefSeq, PubMed]; Structural rearrangements as a recurrent pathogenic mechanism for SETBP1 haploinsufficiency. Publication Status: Online-Only, [RefSeq, PubMed]; The landscape of SETBP1 gene expression and transcription factor activity across human tissues. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 69,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8W5;Q6P6C3;Q9UEF3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042800 histone H3K4 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016604 nuclear body",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q9Y6X0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21731-3",
        "uniprot_id": [
            {
                "id": "TA2R_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21731",
                "type": "external"
            }
        ],
        "mass": 37431.0,
        "length": 343,
        "protein_name": "Thromboxane A2 receptor",
        "gene_name": "TBXA2R",
        "organism": "Human",
        "refseq_name": "thromboxane A2 receptor isoform alpha",
        "refseq_ac": [
            {
                "id": "NP_001051",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001051",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBXA2R",
        "gene_names_refseq": "BDPLT13; TBXA2R; TXA2-R",
        "protein_names_uniprotkb": "Thromboxane A2 receptor; Prostanoid TP receptor; TXA2-R",
        "protein_names_refseq": "prostanoid TP receptor; thromboxane A2 receptor isoform alpha",
        "tax_id": 9606,
        "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); kidney failure (Disease Ontology:DOID:1074); adult respiratory distress syndrome (Disease Ontology:DOID:11394); toxic shock syndrome (Disease Ontology:DOID:14115); thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); asthma (Disease Ontology:DOID:2841); bleeding disorder, platelet-type, 13, susceptibility to (MONDO:MONDO:0800447)",
        "pathway": " (hsa:6915);  (R-HSA-391908);  (R-HSA-416476);  (R-HSA-416482);  (R-HSA-428930)",
        "pathway_count": 5,
        "publication_count": 96,
        "publication_id_list": "10.1101/2023.09.13.557529;10036181;10191087;10567430;10634944;10727532;10861009;11015615;11283606;11294240;11313914;11740958;11742120;11753430;12101119;12120503;12123608;12147288;12180983;12213432;12222762;12433842;12466225;12515866;12519077;12726995;15464062;15699075;15749160;15951850;16182515;16212421;16212495;16268778;16339447;16418336;16754659;16923326;17499743;18088317;1825698;18374420;18434541;1851174;18515384;18577758;18578522;18936096;1905813;19212140;19464661;19651622;20068231;21172430;2171039;21983220;22661716;24715725;25414122;26992070;27072905;28218747;2841328;30007591;30484775;3086311;32971583;35051231;35525325;36936944;7532011;7642548;7883006;7929844;7937899;7965765;8034687;8078484;8117308;8163486;8227091;8246916;8253813;8300593;8613548;8617235;8664309;8816443;9152406;9305846;9308960;9462300;9587408;9694965;9770463;9796816",
        "class_list": "",
        "function": "Activates adenylyl cyclase., [UniProtKB, PubMed]; Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis. Publication Status: Online-Only, [RefSeq, PubMed]; In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits adenylyl cyclase., [UniProtKB, PubMed]; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C., [UniProtKB, PubMed]; The role of TXA2R 5' UTR in differential isoform expression was studied. Exons E1 & E1b associated with TXA2R transcript(s), but their expression was mutually exclusive. Major transcription initiation sites were between -115 & -92 in E1 & at -99 in E1b., [RefSeq, PubMed]; This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]; Thromboxane A2 receptor activation via Galpha13-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits angiogenic sprouting of human endothelial cells., [RefSeq, PubMed]; Transcriptional activity of the 5'flanking region, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75228;Q6DK52;Q9UCY1;Q9UCY2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004961 thromboxane A2 receptor activity;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle",
        "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "P21731-3",
        "record_type": "protein",
        "filter_code": "0001000.1100111.100000.000000000001000000.1000100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NW97-1",
        "uniprot_id": [
            {
                "id": "TMM51_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NW97",
                "type": "external"
            }
        ],
        "mass": 27759.0,
        "length": 253,
        "protein_name": "Transmembrane protein 51",
        "gene_name": "TMEM51",
        "organism": "Human",
        "refseq_name": "transmembrane protein 51 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001129688",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129688",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM51; C1orf72",
        "gene_names_refseq": "C1orf72; TMEM51",
        "protein_names_uniprotkb": "Transmembrane protein 51",
        "protein_names_refseq": "transmembrane protein 51 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55092)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;17081983;19413330;19664994;21406692;23186163;25502872;33592498;33968037;35154160",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K819",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9NW97-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NWC5-1",
        "uniprot_id": [
            {
                "id": "TM45A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NWC5",
                "type": "external"
            }
        ],
        "mass": 31680.0,
        "length": 275,
        "protein_name": "Transmembrane protein 45A",
        "gene_name": "TMEM45A",
        "organism": "Human",
        "refseq_name": "transmembrane protein 45A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_060474",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060474",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM45A; DERP7; DNAPTP4",
        "gene_names_refseq": "DERP7; DNAPTP4; TMEM45A",
        "protein_names_uniprotkb": "Transmembrane protein 45A; DNA polymerase-transactivated protein 4; Dermal papilla-derived protein 7",
        "protein_names_refseq": "DNA polymerase-transactivated protein 4; dermal papilla derived protein 7; transmembrane protein 45A isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55076)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;18767875;22954140;24689342;25872785;26722455;29242379;30410026;32568829;34143331;34410316;35051231;36215666;39097870",
        "class_list": "",
        "function": "Association of Variants in TMEM45A With Keratoglobus., [RefSeq, PubMed]; Data suggest that high levels of TMEM45A expression in tumors may be indicative of potential resistance to cancer therapy, making TMEM45A an interesting biomarker for resistance. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of TMEM45A also inhibited cell adhesion as well as cell invasion. More importantly, suppression of TMEM45A notably downregulated the expression of TGF-b1, TGF-b2, RhoA and ROCK2., [RefSeq, PubMed]; Our study suggests that TMEM45A may work as an oncogene and a new effective therapeutic target for glioma treatment. Publication Status: Online-Only, [RefSeq, PubMed]; Pan-cancer analysis of TMEM45A and exploration of its prognostic value and mechanism in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; TMEM45A Affects Proliferation, Apoptosis, Epithelial-Mesenchymal Transition, Migration, Invasion and Cisplatin Resistance of HPV-Positive Cervical Cancer Cell Lines., [RefSeq, PubMed]; TMEM45A expression is correlated to epidermal keratinization, [RefSeq, PubMed]; Transmembrane protein 45A regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53YW5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q9NWC5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T619-1",
        "uniprot_id": [
            {
                "id": "ZN648_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T619",
                "type": "external"
            }
        ],
        "mass": 62341.0,
        "length": 568,
        "protein_name": "Zinc finger protein 648",
        "gene_name": "ZNF648",
        "organism": "Human",
        "refseq_name": "zinc finger protein 648",
        "refseq_ac": [
            {
                "id": "NP_001009992",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009992",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF648",
        "gene_names_refseq": "ZNF648",
        "protein_names_uniprotkb": "Zinc finger protein 648",
        "protein_names_refseq": "zinc finger protein 648",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127665)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;17081983;30524438;30620550;33054117;35051231",
        "class_list": "",
        "function": "Characterization and evolutionary origin of novel C<sub>2</sub>H<sub>2</sub> zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RP16",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q5T619-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P50876-1",
        "uniprot_id": [
            {
                "id": "R144A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P50876",
                "type": "external"
            }
        ],
        "mass": 32890.0,
        "length": 292,
        "protein_name": "E3 ubiquitin-protein ligase RNF144A",
        "gene_name": "RNF144A",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF144A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_055561",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055561",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNF144A; KIAA0161; RNF144; UBCE7IP4",
        "gene_names_refseq": "RNF144A; RNF144; UBCE7IP4; UIP4; hUIP4",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF144A; 2.3.2.31; RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RNF144A isoform 2; E3 ubiquitin-protein ligase RNF144A; UbcM4-interacting protein 4; probable E3 ubiquitin-protein ligase RNF144A; ring finger protein 144; ubiquitin conjugating enzyme 7 interacting protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9781);  (R-HSA-8866654)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "10431818;10562279;11237011;11740563;15215855;15215856;16307923;16868077;17108083;17130289;17726030;18316726;18359941;18719106;19208625;19410543;19723507;20195266;21203937;21329877;21396873;21554508;22021426;24662292;24807418;24979766;25030448;25170678;25645385;25936802;26086376;26210183;26216882;26344566;26350214;26711259;27569044;27597759;27798111;28904123;29557506;29786170;30171075;31092671;31217245;32157095;32502341;32557973;33067254;35103856;35580925;36284347;37217939;37955227;8625414;8991089",
        "class_list": "",
        "function": "Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:26216882). Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage (PubMed:24979766). Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways (PubMed:37955227). Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination (PubMed:30171075). Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol (PubMed:33067254)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Functional analysis of the mouse counterpart., [RefSeq, PubMed]; RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression. Publication Status: Online-Only, [RefSeq, PubMed]; RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of vaccinia-related kinase 3. Publication Status: Online-Only, [RefSeq, PubMed]; Solution structure of the zinc finger domain of human RNF144A ubiquitin ligase., [RefSeq, PubMed]; This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W4Y6;Q585H5",
        "ec_number_list": [
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0085020 protein K6-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "P50876-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HCU5-1",
        "uniprot_id": [
            {
                "id": "SEC12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HCU5",
                "type": "external"
            }
        ],
        "mass": 45468.0,
        "length": 417,
        "protein_name": "Guanine nucleotide-exchange factor SEC12",
        "gene_name": "PREB",
        "organism": "Human",
        "refseq_name": "guanine nucleotide-exchange factor SEC12 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001317414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PREB; SEC12",
        "gene_names_refseq": "PREB; SEC12",
        "protein_names_uniprotkb": "Guanine nucleotide-exchange factor SEC12; Prolactin regulatory element-binding protein",
        "protein_names_refseq": "guanine nucleotide-exchange factor SEC12 isoform 3; guanine nucleotide-exchange factor SEC12; mammalian guanine nucleotide exchange factor mSec12; prolactin regulatory element-binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10113);  (R-HSA-204005);  (R-HSA-381038);  (R-HSA-5694530)",
        "pathway_count": 4,
        "publication_count": 132,
        "publication_id_list": "10445031;10559958;10559959;10601334;10652252;10679020;10747087;10788476;10825291;10827079;10903204;10920239;10982397;11035026;11237011;11285137;11306556;11927603;12070132;12204115;12235121;12237308;12735795;15037235;15466936;16129679;16303754;16461360;16495487;16539657;16624868;16912714;17005010;17010120;17038314;17192411;17287728;17316621;17499046;17562788;17607000;17684057;18025080;18283111;18287528;18664523;18843296;19164740;19265014;19269366;19566487;19638414;19656848;20427317;20477988;20533886;20545907;20679433;20805473;20966969;21282569;21478858;21525241;21532587;21689688;21878990;22013193;22157747;22675024;23378591;23479643;23698585;23852824;23864707;24119662;24917561;25202031;25406594;25492864;25586378;25619252;25619253;25892735;26992070;27170179;28218747;28442536;28515233;28832583;29242379;29437277;29493099;29557506;29601978;29632046;29769354;30315122;30410026;30545919;31530632;31611695;31844290;32157095;32350084;32358066;32502341;32897882;33392160;33691108;33717175;33912179;33968037;34087483;34171305;35051231;35251023;38665916;7590364;8221884;8620540;8663406;8666242;9037597;9094723;9150144;9177194;9307973;9395526;9450183;9472029;9473480;9647643",
        "class_list": "",
        "function": "Administration of recombinant adenovirus containing human PREB to db/db, ob/ob, and DIO mice diminished glucose, insulin, and pyruvate tolerance indicating PREB to be a negative regulator of liver gluconeogenic genes., [RefSeq, PubMed]; Both cTAGE5 and SEC12 were exported with TANGO1 in large COPII carriers., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:32358066). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:32358066)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]., [RefSeq]; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53SZ8;Q9UH94",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051020 GTPase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042953 lipoprotein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0003400 regulation of COPII vesicle coating",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q9HCU5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TCS8-1",
        "uniprot_id": [
            {
                "id": "PNPT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TCS8",
                "type": "external"
            }
        ],
        "mass": 85951.0,
        "length": 783,
        "protein_name": "Polyribonucleotide nucleotidyltransferase 1, mitochondrial",
        "gene_name": "PNPT1",
        "organism": "Human",
        "refseq_name": "polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_149100",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149100",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNPT1; PNPASE",
        "gene_names_refseq": "COXPD13; DFNB70; OLD35; PNPASE; PNPT1; SCA25; old-35",
        "protein_names_uniprotkb": "Polyribonucleotide nucleotidyltransferase 1, mitochondrial; 2.7.7.8; 3'-5' RNA exonuclease OLD35; PNPase 1; PNPase old-35; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein",
        "protein_names_refseq": "3'-5' RNA exonuclease OLD35; PNPase 1; PNPase old-35; polynucleotide phosphorylase 1; polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor; polyribonucleotide nucleotidyltransferase 1, mitochondrial",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 25 (Disease Ontology:DOID:0050974); autosomal recessive nonsyndromic deafness 70 (Disease Ontology:DOID:0110521); combined oxidative phosphorylation deficiency 13 (Disease Ontology:DOID:0111467)",
        "pathway": " (hsa:87178);  (R-HSA-9836573)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "11237011;12419256;12473748;12721301;12798676;15096047;16055741;16410805;16934922;16966381;17525332;18083836;18083837;18501193;19509288;19608861;19864255;20068230;20068231;20200222;20547861;20691904;21406692;22210891;22661577;22815474;23084290;23084291;23186163;23221631;23473033;23741365;25418920;25576301;25880248;26154972;26992070;27846572;27920218;28218747;28228285;28510447;28514659;28904123;29146908;29242379;29288125;29366917;29437277;29493099;29557506;29967381;30046113;30315122;31154438;31373491;31844290;32119511;32157095;32350084;32357974;32365187;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33633747;33912179;33936100;33981976;34171305;34211107;34357683;34725712;35051231;35411967;35481630;35580925;36010968;36241641;39019044;39218215;40914422",
        "class_list": "",
        "function": "A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss., [RefSeq, PubMed]; An important role for hPNPase(old-35)in growth control associated with terminal differentiation and cellular senescence., [RefSeq, PubMed]; Demonstrate that the hPNPase is localized in mitochondria; finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence, [RefSeq, PubMed]; Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency., [RefSeq, PubMed]; Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial homeostasis., [RefSeq, PubMed]; Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring, [RefSeq, PubMed]; RNA-binding protein implicated in numerous RNA metabolic processes (PubMed:29967381, PubMed:39019044). Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction (PubMed:29967381, PubMed:39019044). Mitochondrial intermembrane factor with RNA-processing exoribonulease activity (PubMed:29967381, PubMed:39019044). Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (PubMed:29967381, PubMed:39019044). Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381, PubMed:39019044). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The molecular mechanism of the growth-arresting property of hPNPaseold-35, [RefSeq, PubMed]; The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53SU0;Q68CN1;Q7Z7D1;Q8IWX1;Q96T05;Q9BRU3;Q9BVX0",
        "ec_number_list": [
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.7.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.8",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0035198 miRNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004654 polyribonucleotide nucleotidyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0000964 mitochondrial RNA 5'-end processing;GO:0006397 mRNA processing;GO:0051260 protein homooligomerization",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q8TCS8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4JDL3-1",
        "uniprot_id": [
            {
                "id": "PTN20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4JDL3",
                "type": "external"
            }
        ],
        "mass": 48423.0,
        "length": 420,
        "protein_name": "Tyrosine-protein phosphatase non-receptor type 20",
        "gene_name": "PTPN20",
        "organism": "Human",
        "refseq_name": "tyrosine-protein phosphatase non-receptor type 20 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001035816",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035816",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPN20; PTPN20A; PTPN20B",
        "gene_names_refseq": "CT126; PTPN20A; PTPN20B; PTPN20; bA142I17.1; bA42B19.1",
        "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 20; 3.1.3.48; hPTPN20",
        "protein_names_refseq": "protein tyrosine phosphatase, non-receptor type 20A; protein tyrosine phosphatase, non-receptor type 20B; tyrosine-protein phosphatase non-receptor type 20 isoform 1; tyrosine-protein phosphatase non-receptor type 20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26095);  (R-HSA-9008059)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11145836;11237011;11839743;12096920;12381835;12809600;15527767;15790311;17525332;18390730;20935647;24481253;25729923;25892735;27060871;28092676;33592498;35051231;37359510",
        "class_list": "",
        "function": "Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of hPTPN20a as a novel and widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization, [RefSeq, PubMed]; The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]., [RefSeq]; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNH8;B7ZKV3;Q4JDG6;Q4JDK1;Q4JDK5;Q4JDK6;Q4JDK8;Q4JDK9;Q4JDL0;Q4JDL1;Q4JDL4;Q4JDL5;Q4JDL6;Q4JDL7;Q4JDL8;Q5RJ33;Q5T1G3",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004721 phosphoprotein phosphatase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0034451 centriolar satellite",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q4JDL3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N4Q0-1",
        "uniprot_id": [
            {
                "id": "PTGR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N4Q0",
                "type": "external"
            }
        ],
        "mass": 40140.0,
        "length": 377,
        "protein_name": "Prostaglandin reductase 3",
        "gene_name": "PTGR3",
        "organism": "Human",
        "refseq_name": "prostaglandin reductase 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001293022",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293022",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTGR3; ZADH2",
        "gene_names_refseq": "PRG-3; PTGR-3; PTGR3; ZADH2",
        "protein_names_uniprotkb": "Prostaglandin reductase 3; 1.3.1.48; PRG-3; Zinc-binding alcohol dehydrogenase domain-containing protein 2",
        "protein_names_refseq": "prostaglandin reductase 3 isoform 2; zinc binding alcohol dehydrogenase domain containing 2; zinc-binding alcohol dehydrogenase domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284273)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;19690890;20112406;20877624;23186163;23481700;24715725;25418920;25469497;25576301;26154972;26811146;26992070;27600516;27846572;28834231;28904123;29557506;30315122;30372681;30429286;31154438;31217245;31844290;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32938616;32983136;33141586;33298915;33537174;33592498;33717175;33912179;34143546;34171305;34185709;35051231;35580925;36010968;36224673;36284347",
        "class_list": "",
        "function": "Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation., [UniProtKB, UniProtKB]; In patients with late-onset Alzheimer disease, a number of differentially methylated postitions were hypomethylated in ZADH2 compared with controls., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib., [RefSeq, PubMed]; [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA15;B4DZ91",
        "ec_number_list": [
            {
                "id": "1.3.1.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74",
                "type": "external"
            },
            {
                "id": "1.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome",
        "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0045599 negative regulation of fat cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8N4Q0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NUP7-1",
        "uniprot_id": [
            {
                "id": "PP4R4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NUP7",
                "type": "external"
            }
        ],
        "mass": 99452.0,
        "length": 873,
        "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 4",
        "gene_name": "PPP4R4",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_066009",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066009",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP4R4; KIAA1622; PP4R4",
        "gene_names_refseq": "CFAP14; KIAA1622; PP4R4; PPP4R4",
        "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 4",
        "protein_names_refseq": "HEAT-like repeat-containing protein; cilia and flagella associated protein 14; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 2; serine/threonine-protein phosphatase 4 regulatory subunit 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57718)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;18452278;18715871;23481700;25505266;28904123;29485866;29557506;30429286;32357974;32938616;33298915;33912179;33936100;33968037;33981976;34171305;35580925;36010968",
        "class_list": "",
        "function": "PP4R4 forms a novel cytosolic complex with PP4c, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4, and the regulatory subunits of PP4c have evolved different modes of interaction with the catalytic subunit, [RefSeq, PubMed]; Putative regulatory subunit of serine/threonine-protein phosphatase 4., [UniProtKB]; The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BUF8;Q9HCF0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0019888 protein phosphatase regulator activity;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008287 protein serine/threonine phosphatase complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q6NUP7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULM0-1",
        "uniprot_id": [
            {
                "id": "PKHH1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULM0",
                "type": "external"
            }
        ],
        "mass": 151232.0,
        "length": 1364,
        "protein_name": "Pleckstrin homology domain-containing family H member 1",
        "gene_name": "PLEKHH1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family H member 1",
        "refseq_ac": [
            {
                "id": "NP_065766",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065766",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHH1; KIAA1200",
        "gene_names_refseq": "PLEKHH1",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family H member 1; PH domain-containing family H member 1",
        "protein_names_refseq": "PH domain-containing family H member 1; pleckstrin homology domain containing, family H (with MyTH4 domain) member 1; pleckstrin homology domain-containing family H member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57475)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;25576301;26992070;28411811;29557506;30379171;32157095;32387766;32488085;33392160;33912179;33968037;34087483;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8X6;Q6PJL4;Q6ZWC7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005856 cytoskeleton",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9ULM0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30566-1",
        "uniprot_id": [
            {
                "id": "PUR8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30566",
                "type": "external"
            }
        ],
        "mass": 54889.0,
        "length": 484,
        "protein_name": "Adenylosuccinate lyase",
        "gene_name": "ADSL",
        "organism": "Human",
        "refseq_name": "adenylosuccinate lyase isoform a",
        "refseq_ac": [
            {
                "id": "NP_000017",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000017",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ADSL; AMPS",
        "gene_names_refseq": "ADSL; AMPS; ASASE; ASL",
        "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ADSL; ASL; ASase; Adenylosuccinase",
        "protein_names_refseq": "adenylosuccinase; adenylosuccinate lyase isoform a",
        "tax_id": 9606,
        "disease": "adenylosuccinase lyase deficiency (Disease Ontology:DOID:0050762); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:158);  (R-HSA-73817)",
        "pathway_count": 2,
        "publication_count": 110,
        "publication_id_list": "10090474;10888601;10958654;11096114;11237011;11381136;12016589;12070256;12368987;12450384;12833398;1302001;14529546;15786719;1592113;16839792;16973378;17224163;18388293;18477386;18609073;18691976;19405474;19413330;19608861;19651622;1967654;20068231;21320556;2147474;2183217;21960835;22812634;24366607;24714562;24715725;25114211;25810538;26154972;26811146;26992070;27846572;28510447;28904123;29317506;29437277;29467457;29557506;30315122;30429286;30573755;30833945;31092671;31154438;31530632;31729379;31844290;31848261;31998317;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34229054;34357683;34561969;34725712;34932366;35051231;35138101;35251023;35561310;35580925;36215666;36241641;36284347;37842880;38665916;40914422;4348202;4726295;762062;7706277;7903306;8089153;8110788;8366112;8380692;8404037;8567683;9266401;9545543",
        "class_list": "",
        "function": "ADSL undergoes conformational changes during catalysis which, together with the crystal structure of a hitherto undetermined product bound conformation, explains the molecular origin of disease for several modern human ADSL mutants. Publication Status: Online-Only, [RefSeq, PubMed]; Adenylosuccinate lyase (ADSL) is an EglN2 hydroxylase substrate in triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Electroclinical features and phenotypic differences in adenylosuccinate lyase deficiency: Long-term follow-up of seven patients from four families and appraisal of the literature., [RefSeq, PubMed]; Involved in endometrial cancer aggressiveness by regulating expression of killer cell lectin-like receptor C3, [RefSeq, PubMed]; The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QY76;O75495;Q5TI34",
        "ec_number_list": [
            {
                "id": "4.3.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity;GO:0016829 lyase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007584 response to nutrient;GO:0042594 response to starvation;GO:0001666 response to hypoxia;GO:0014850 response to muscle activity;GO:0006177 GMP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P30566-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WUY3-1",
        "uniprot_id": [
            {
                "id": "PRUN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WUY3",
                "type": "external"
            }
        ],
        "mass": 340635.0,
        "length": 3088,
        "protein_name": "Protein prune homolog 2",
        "gene_name": "PRUNE2",
        "organism": "Human",
        "refseq_name": "protein prune homolog 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001294976",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001294976",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRUNE2; BMCC1; BNIPXL; C9orf65; KIAA0367",
        "gene_names_refseq": "BMCC1; BNIPXL; C9orf65; KIAA0367; PRUNE2",
        "protein_names_uniprotkb": "Protein prune homolog 2; BNIP2 motif-containing molecule at the C-terminal region 1",
        "protein_names_refseq": "BCH motif-containing molecule at the carboxyl terminal region 1; BNIP2 motif containing molecule at the carboxyl terminal region 1; BNIP2 motif-containing molecule at the C-terminal region 1; olfaxin; protein prune homolog 2 isoform 2; protein prune homolog 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:158471)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;16288218;17081983;17360660;19319183;19760627;21234814;23033978;24040105;24715725;26080435;26992070;27846572;29557506;30429286;30484775;31092671;31844290;32157095;32488085;32938616;32983136;33592498;33968037;34087483;34185709;35051231;35580925;35929169;36010968;36564567;37938771",
        "class_list": "",
        "function": "BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells, [RefSeq, PubMed]; BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene., [RefSeq, PubMed]; FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer., [RefSeq, PubMed]; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells., [UniProtKB, PubMed, UniProtKB, UniProtKB]; OBSCN and C9orf65 comprise a highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas., [RefSeq, PubMed]; Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer., [RefSeq, PubMed]; The longer BMCC1-1 isoform is upregulated in PCa tissues and metastases, [RefSeq, PubMed]; The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems., [RefSeq, PubMed]; The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 97,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KYC4;B4DQH8;O15073;Q58A63;Q5JUB6;Q5T304;Q5T476;Q6T2V6;Q6T2V7;Q8N665",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0098793 presynapse",
        "go_biological_process": "GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q8WUY3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.001000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P78317-1",
        "uniprot_id": [
            {
                "id": "RNF4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P78317",
                "type": "external"
            }
        ],
        "mass": 21319.0,
        "length": 190,
        "protein_name": "E3 ubiquitin-protein ligase RNF4",
        "gene_name": "RNF4",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001171938",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171938",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNF4; RES4-26; SNURF",
        "gene_names_refseq": "RES4-26; RNF4; SLX5; SNURF",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF4; 2.3.2.27; Protein SNURF; RING finger protein 4; Small nuclear ring finger protein",
        "protein_names_refseq": "E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4 isoform 1; E3 ubiquitin-protein ligase RNF4; RING-type E3 ubiquitin transferase RNF4; small nuclear RING finger protein",
        "tax_id": 9606,
        "disease": "Angelman syndrome (Disease Ontology:DOID:1932)",
        "pathway": " (hsa:6047);  (R-HSA-5693607);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 134,
        "publication_id_list": "10713105;10859164;11062501;11080452;11139606;11237011;11301010;11350924;11376695;11390642;12152085;12545175;12578958;12646216;12791985;12885770;14576433;14734113;15189136;15190204;15224091;15224092;15571818;15707391;15707587;16148040;16153896;16327781;16360315;16530042;16595681;16849449;16885023;16954532;17081983;17575048;17928296;17965729;18171670;18408734;18452278;18662542;18669648;18805091;18923075;18971343;19028597;19307308;19352404;19357644;19419957;19452197;19489725;19690332;19779455;19851334;19874575;19940261;20026589;20154705;20212317;20233725;20943951;21052091;21240188;21263215;21325134;21335604;21659603;21680713;21777809;22021381;22024395;22231403;2261476;22635276;22661229;22661230;22792074;22977173;23028697;23345434;23468639;24714562;25113031;25122754;25418920;25558984;25576301;25659039;25948581;26728094;26992070;27846572;27920218;28063628;28514659;28832583;28842558;28904123;29242379;29557506;29632046;29632711;30429286;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32488085;32502341;32897882;32938616;32983136;33691108;33968037;34171305;35013556;35580925;35926659;36153321;36172813;38253038;38340377;38530355;39418304;9380723;9479498;9668046;9705271;9734812",
        "class_list": "",
        "function": "E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Nuclear p62 condensates stabilize the promyelocytic leukemia nuclear bodies by sequestering their ubiquitin ligase RNF4., [RefSeq, PubMed]; RNF4 prevents genomic instability caused by chronic DNA under-replication., [RefSeq, PubMed]; RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus., [RefSeq, PubMed]; RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication. Publication Status: Online-Only, [RefSeq, PubMed]; RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6D6;D6RF58;Q49AR8",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.1.1.357",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "3.4.19.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0016605 PML body",
        "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P78317-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6S545-1",
        "uniprot_id": [
            {
                "id": "POTEH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6S545",
                "type": "external"
            }
        ],
        "mass": 60965.0,
        "length": 545,
        "protein_name": "POTE ankyrin domain family member H",
        "gene_name": "POTEH",
        "organism": "Human",
        "refseq_name": "POTE ankyrin domain family member H",
        "refseq_ac": [
            {
                "id": "NP_001129685",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129685",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POTEH; A26C3; ACTBL1; POTE22",
        "gene_names_refseq": "A26C3; ACTBL1; CT104.7; POTE22; POTEH",
        "protein_names_uniprotkb": "POTE ankyrin domain family member H; ANKRD26-like family C member 3; POTE-22; Prostate, ovary, testis-expressed protein on chromosome 22",
        "protein_names_refseq": "ANKRD26-like family C member 3; POTE ankyrin domain family member H; actin, beta-like 1; cancer/testis antigen family 104, member 7; prostate, ovary, testis-expressed protein on chromosome 22; protein expressed in prostate, ovary, testis, and placenta 22; protein expressed in prostate, ovary, testis, and placenta POTE14 like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23784)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;15276201;18477386;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2CEK4;A6NCI1;A9Z1W0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6S545-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YD1-1",
        "uniprot_id": [
            {
                "id": "PTOV1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YD1",
                "type": "external"
            }
        ],
        "mass": 46869.0,
        "length": 416,
        "protein_name": "Prostate tumor-overexpressed gene 1 protein",
        "gene_name": "PTOV1",
        "organism": "Human",
        "refseq_name": "prostate tumor-overexpressed gene 1 protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001292034",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292034",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTOV1; ACID2; PP642; PRO20092",
        "gene_names_refseq": "ACID2; PTOV-1; PTOV1",
        "protein_names_uniprotkb": "Prostate tumor-overexpressed gene 1 protein; Activator interaction domain-containing protein 2; PTOV-1",
        "protein_names_refseq": "activator interaction domain-containing protein 2; prostate tumor overexpressed 1; prostate tumor-overexpressed gene 1 protein isoform 1; prostate tumor-overexpressed gene 1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53635)",
        "pathway_count": 1,
        "publication_count": 84,
        "publication_id_list": "11237011;11313889;12598323;12975309;14657022;15498874;15713644;15778465;16639697;17641689;18451224;19651622;21110951;23481700;24714562;25418920;25576301;26154972;26375851;26728094;26811146;26929215;26992070;27600516;27846572;27920218;28218747;28228285;28651486;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29779948;29786170;30315122;30410026;30922918;31050705;31083670;31154438;31222486;31387622;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34211107;34509645;34561969;35051231;35318648;35580925;36010968;36241641;36284347;37938771",
        "class_list": "",
        "function": "Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MED25 and PTOV1 differentially modulate retinoic acid sensitivity in cancer cells depending on their expression levels., [RefSeq, PubMed]; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, PubMed, PubMed, PubMed]; PTOV1 and PIN1 interact and exert oncogenic role in MDA-MB-231 cells by sharing the similar expression profile at transcriptional and translational level which can be a promising hub for therapeutic target. Publication Status: Online-Only, [RefSeq, PubMed]; PTOV1 assists flotillin-1 in its translocation to the nucleus and both proteins are required for cell proliferation., [RefSeq, PubMed]; PTOV1 interaction with translation complexes and its direct binding to ALDH1A1 and CCNG2 promoters found here reveal the PTOV1 capacity to modulate the expression of critical genes at multiple levels in aggressive cancers., [RefSeq, PubMed]; PTOV1 is overexpressed in high-grade prostatic intraepithelial neoplasia associated with cancer and is a potential marker for studying the carcinogenesis and progression of prostate cancer., [RefSeq, PubMed]; The acquisition of resistance in laryngeal cancer seems to be related to PTOV1, [RefSeq, PubMed]; This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]; This protein, overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle., [RefSeq, PubMed]; This study revealed PTOV1 as a poor prognosis factor for NSCLC patients, and targeting PTOV1 can be a strategy to increase chemosensitivity in NSCLC. Publication Status: Online-Only, [RefSeq, PubMed]; This study takes the lead to demonstrate that the overexpressed PTOV1 plays a vital role in the tumorigenesis and progression of esophageal squamous cell carcinoma, and it is potentially a valuable prognostic predicator and new chemotherapeutic target for esophageal squamous cell carcinoma, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UXX7;Q96BU3;Q9HBN4;Q9NYL1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005667 transcription regulator complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q86YD1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N4L2-1",
        "uniprot_id": [
            {
                "id": "PP4P2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N4L2",
                "type": "external"
            }
        ],
        "mass": 28081.0,
        "length": 257,
        "protein_name": "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase",
        "gene_name": "PIP4P2",
        "organism": "Human",
        "refseq_name": "type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase",
        "refseq_ac": [
            {
                "id": "NP_061180",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061180",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIP4P2; TMEM55A",
        "gene_names_refseq": "PIP4P2; TMEM55A",
        "protein_names_uniprotkb": "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; 3.1.3.78; PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A; Type 2 PtdIns-4,5-P2 4-Ptase",
        "protein_names_refseq": "PtdIns-4,5-P(2) 4-phosphatase type II; ptdIns-4,5-P2 4-Ptase II; transmembrane protein 55A; type 2 PtdIns-4,5-P2 4-Ptase; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type II PtdIns-4,5-P(2) 4-phosphatase; type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55529)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;16365287;23186163;23481700;26992070;28649982;28904123;29242379;29769354;31020640;31844290;32157095;32350084;32938616;32983136;33592498;34357683;34433824;34932366;35051231;35154160;35251023;38880622",
        "class_list": "",
        "function": "CRISPRa Analysis of Phosphoinositide Phosphatases Shows That TMEM55A Is a Positive Regulator of Autophagy., [RefSeq, PubMed]; Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification and characterization of two previously undescribed human enzymes, PtdIns-4,5-P(2) 4-phosphatase type I and type II, [RefSeq, PubMed]; TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9H4;Q68CU2",
        "ec_number_list": [
            {
                "id": "3.1.3.78",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.78",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane",
        "go_biological_process": "GO:0050765 negative regulation of phagocytosis;GO:0046856 phosphatidylinositol dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8N4L2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75192-1",
        "uniprot_id": [
            {
                "id": "PX11A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75192",
                "type": "external"
            }
        ],
        "mass": 28353.0,
        "length": 247,
        "protein_name": "Peroxisomal membrane protein 11A",
        "gene_name": "PEX11A",
        "organism": "Human",
        "refseq_name": "peroxisomal membrane protein 11A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001258501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX11A; PEX11",
        "gene_names_refseq": "PEX11-ALPHA; PEX11A; PEX11alpha; PMP28; hsPEX11p",
        "protein_names_uniprotkb": "Peroxisomal membrane protein 11A; 28 kDa peroxisomal integral membrane protein; HsPEX11p; PEX11-alpha; PMP28; Peroxin-11A; Peroxisomal biogenesis factor 11A; Protein PEX11 homolog alpha",
        "protein_names_refseq": "28 kDa peroxisomal integral membrane protein; peroxin-11A; peroxisomal biogenesis factor 11A; peroxisomal integral membrane protein 28-kDa; peroxisomal membrane protein 11A isoform 2; peroxisomal membrane protein 11A; protein PEX11 homolog alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8800);  (R-HSA-1989781);  (R-HSA-9841922)",
        "pathway_count": 3,
        "publication_count": 50,
        "publication_id_list": "10425206;10558993;10704444;10777541;10835357;10882139;11027271;11237011;11267664;12118000;12177166;12505311;12582161;12829629;1310260;15067378;15130092;15635043;16380219;16567422;16972786;17761950;18540824;18719978;18848529;19043829;19088433;19172745;19710929;19934321;20110263;20826455;24196956;28411811;32938616;33329381;34171305;35051231;7685352;7892212;8521497;8521498;8647822;9012850;9065481;9171241;9714566;9744270;9748239;9792670",
        "class_list": "",
        "function": "Cooperation with other transcription factors may be differentially involved in selective transactivation of the PEX11alpha gene by different peroxisome proliferator-activated receptor subtypes., [RefSeq, PubMed]; Coordinates peroxisome membrane proliferation and maintenance, [RefSeq, PubMed]; May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DV88",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0016557 peroxisome membrane biogenesis;GO:0044375 regulation of peroxisome size",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "O75192-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5HYI8-1",
        "uniprot_id": [
            {
                "id": "RABL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5HYI8",
                "type": "external"
            }
        ],
        "mass": 26423.0,
        "length": 236,
        "protein_name": "Rab-like protein 3",
        "gene_name": "RABL3",
        "organism": "Human",
        "refseq_name": "rab-like protein 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_776186",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776186",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RABL3",
        "gene_names_refseq": "PNCA5; RABL3",
        "protein_names_uniprotkb": "Rab-like protein 3; 3.6.5.2",
        "protein_names_refseq": "rab-like protein 3 isoform 2; rab-like protein 3",
        "tax_id": 9606,
        "disease": "pancreatic cancer (Disease Ontology:DOID:1793); pancreatic cancer, susceptibility to, 5 (MONDO:MONDO:0032867)",
        "pathway": " (hsa:285282)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "11237011;20068231;20112406;20596630;25418920;25892735;26375851;26811146;26992070;27164297;27600516;27846572;27920218;28063628;28228285;28443498;28739496;28832583;28834231;28904123;29242379;29393594;29493099;29632046;29769354;30429286;30524438;31406347;31844290;32157095;32265295;32387766;32897882;32983136;33353859;33438143;33717175;33724601;33968037;34171305;34357683;34561969;34631898;34932366;35051231;35580925;36052645;36581221",
        "class_list": "",
        "function": "CircCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression. Publication Status: Online-Only, [RefSeq, PubMed]; Germline sequence analysis of RABL3 in a large series of pancreatic ductal adenocarcinoma patients reveals no evidence of deleterious variants., [RefSeq, PubMed]; Hepatocellular carcinoma patients with positive expression for both Rabl3 and Cullin7 had a remarkably shorter survival time compared with patients with negative expression for both proteins., [RefSeq, PubMed]; Knockdown of RABL3 suppresses the proliferation and invasion of oral squamous cell carcinoma through inactivating the FAK/AKT pathway., [RefSeq, PubMed]; Low-frequency of RABL3 pathogenetic variants in hereditary and familial pancreatic cancer., [RefSeq, PubMed]; Our studies suggest that the Rabl3 is a valuable marker of hepatocellular carcinoma progression and that the overexpression of Rabl3 plays an important role in the development and pathogenesis of hepatocellular carcinoma., [RefSeq, PubMed]; Rabl3 can be considered as a novel candidate in the control of tumorigenesis and as a new target for anticancer treatment., [RefSeq, PubMed]; Small GTPase required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (PubMed:31406347). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity). Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis (PubMed:36052645)., [UniProtKB, PubMed, UniProtKB, PubMed]; Small GTPase required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development. Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis., [UniProtKB, UniProtKB]; We examine the correlation between the expression level of Rabl3 and survival of non-small cell lung cancer (NSCLC) patients in three independent cohorts containing 484 patients. We found high expression of Rabl3 might inhibit cell death in non-small cell lung cancer via repression of MAPK8/9/10-mediated autophagy Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WUD3",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006886 intracellular protein transport;GO:0050821 protein stabilization;GO:0030183 B cell differentiation;GO:0033077 T cell differentiation in thymus",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q5HYI8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NUN9-1",
        "uniprot_id": [
            {
                "id": "ZN746_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NUN9",
                "type": "external"
            }
        ],
        "mass": 69136.0,
        "length": 644,
        "protein_name": "Zinc finger protein 746",
        "gene_name": "ZNF746",
        "organism": "Human",
        "refseq_name": "zinc finger protein 746 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001156946",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156946",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF746; PARIS",
        "gene_names_refseq": "PARIS; ZNF746",
        "protein_names_uniprotkb": "Zinc finger protein 746; PARIS; Parkin-interacting substrate",
        "protein_names_refseq": "parkin-interacting substrate; parkin-interacting sustrate; zinc finger protein 746 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:155061);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;21376232;2163759;24145959;25418920;25880248;26324925;27600516;27846572;28832583;28904123;29242379;29393594;29508533;29557506;29632046;30315122;30429286;30524438;31217245;31844290;31856708;32157095;32265295;32387766;32488085;32502341;32938616;32983136;33592498;33691108;33723766;33912179;33968037;33981976;34062393;34932366;35051231;35580925;37730102;37870275;37938771;38103579;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population., [RefSeq, PubMed]; PARIS overexpression leads to reduced mitochondrial number and structural abnormalities, [RefSeq, PubMed]; PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification., [RefSeq, PubMed]; PARIS(ZNF746) is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain., [RefSeq, PubMed]; These findings suggest that inhibition of ZNF746 suppresses the invasion and epithelial to mesenchymal transition molecules in H460 NSCLC cells and ZNF746 may be an important target molecule in lung tumorigenesis., [RefSeq, PubMed]; Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's disease cell model: Implications for therapeutic targeting., [RefSeq, PubMed]; ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway., [RefSeq, PubMed]; ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6Z9;Q6ZRF9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q6NUN9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96BZ4-1",
        "uniprot_id": [
            {
                "id": "PLD4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96BZ4",
                "type": "external"
            }
        ],
        "mass": 55626.0,
        "length": 506,
        "protein_name": "5'-3' exonuclease PLD4",
        "gene_name": "PLD4",
        "organism": "Human",
        "refseq_name": "5'-3' exonuclease PLD4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_620145",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620145",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLD4; C14orf175; PRO5775",
        "gene_names_refseq": "C14orf175; PLD4; SLEB18",
        "protein_names_uniprotkb": "5'-3' exonuclease PLD4; (S,S)-bis(monoacylglycero)phosphate synthase PLD4; 2.3.1.-; 3.1.16.1; Phospholipase D family member 4; Phospholipase D4",
        "protein_names_refseq": "(S,S)-bis(monoacylglycero)phosphate synthase PLD4; 5'-3' exonuclease PLD4 isoform 2; 5'-3' exonuclease PLD4; PLD 4; choline phosphatase 4; phosphatidylcholine-hydrolyzing phospholipase D4",
        "tax_id": 9606,
        "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074); systemic lupus erythematosus 18 (MONDO:MONDO:1060185)",
        "pathway": " (hsa:122618);  (R-HSA-1483148);  (R-HSA-1855204);  (R-HSA-2029485)",
        "pathway_count": 4,
        "publication_count": 94,
        "publication_id_list": "10224668;10579907;10593988;10866302;11022047;11022048;11042108;11118617;11237011;11425868;11749377;11909533;12223481;12660731;12747803;12869549;12975309;1333955;15037625;15140260;15161916;15294978;15316017;15474001;15536084;15579586;15702972;15790568;15809313;16094384;16107206;1644792;16497229;16678913;1718960;17590538;19179337;21641550;23124809;24190977;2550068;25502872;26992070;2841328;28467828;28657654;28904123;29391424;29741879;30111894;32350084;32387766;32502341;32983136;33043033;33141586;33392160;34357683;34433824;34509645;34620855;34932366;35051231;35154160;35580925;36284347;37074911;3718705;37840148;38537643;38697119;39423811;40931063;7517665;7721860;7761412;7890667;8228618;8380172;8407970;8454637;8530101;8530346;8657103;8662638;8723348;8769125;9140189;9360711;9407135;9430698;9593664;9761774;9973503",
        "class_list": "",
        "function": "Can alternatively catalyze the transfer (transphosphatidylation) of a glycerol group between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG). The reaction is characterized by an R-to-S stereo-inversion which is essential for the resistance of the produced (S,S)-bis(monoacylglycero)phosphates (BMPs) to lysosomal degradation. The resulting BMPs, are phospholipids required for the formation of lysosomal intralumenal vesicles (ILVs) where lipid degradation can occur., [UniProtKB, PubMed]; Lysosomal 5'->3' exonuclease that functions in nucleic-acid sensing by immune cells. Hydrolyzes phosphodiester bond in single-stranded RNA and DNA molecules, with a higher efficiency for molecules with 5' uridine and guanosine residues. It can stall at certain sites and does not necessarily proceed to complete exonucleolytic degradation, thereby producing nucleoside 3'-monophosphates but also 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894, PubMed:34620855, PubMed:38537643, PubMed:38697119, PubMed:40931063). Through the processing of self and exogenous RNA and DNA molecules, provides molecular signals to toll-like receptors (TLRs) in innate immunity. Partially redundant with PLD3, it cooperates with the RNase T2/RNASET2 to generate 2',3'-cGMP and cytidine-rich RNA fragments that occupy the two TLR7 ligand-binding pockets, to trigger receptor activation and signaling (PubMed:38697119). Can exert polynucleotide phosphatase activity toward 5'-phosphorylated single-stranded DNA substrates although at a slow rate (PubMed:38537643). Could play a role in phagocytosis of activated microglia (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]; We determined that PLD4 is a novel susceptibility gene for sysetmic sclerosis in Japanese, thus confirming the involvement of PLD4 in autoimmunity., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 17,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 2,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UWD2",
        "ec_number_list": [
            {
                "id": "3.1.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.16.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0004534 5'-3' RNA exonuclease activity;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity;GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0032588 trans-Golgi network membrane;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006909 phagocytosis;GO:1900015 regulation of cytokine production involved in inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "Q96BZ4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86XN7-1",
        "uniprot_id": [
            {
                "id": "PRSR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86XN7",
                "type": "external"
            }
        ],
        "mass": 95698.0,
        "length": 944,
        "protein_name": "Proline and serine-rich protein 1",
        "gene_name": "PROSER1",
        "organism": "Human",
        "refseq_name": "proline and serine-rich protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_079414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROSER1; C13orf23; KIAA2032",
        "gene_names_refseq": "C13orf23; PROSER1",
        "protein_names_uniprotkb": "Proline and serine-rich protein 1",
        "protein_names_refseq": "proline and serine-rich protein 1 isoform 1; proline and serine-rich protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80209)",
        "pathway_count": 1,
        "publication_count": 82,
        "publication_id_list": "11237011;19413330;23301498;23481700;24714562;24715725;25576301;25645385;25880248;25892735;26154972;26375851;26728094;26992070;27600516;27846572;28218747;28228285;28314751;28514659;28832583;28834231;29237092;29242379;29437277;29508533;29557506;29786170;30059200;30315122;30397120;30410026;30429286;30524438;31154438;31217245;31492838;31844290;31848261;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33592498;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34667079;34932366;35051231;35138101;35254053;35289036;35513511;36010968;36215666;36241641;38253038;38665916;39302247;39531497;39534244;40136647",
        "class_list": "",
        "function": "Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs)., [UniProtKB, PubMed]; PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a conserved protein containing proline and serine rich regions. These regions may be important in protein-protein interactions. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 7,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 24,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 24,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 24,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 70,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 31,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJ97;Q6P2S2;Q7Z3X5;Q8N3D2;Q8N3P1;Q9H9M1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q86XN7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P49459-1",
        "uniprot_id": [
            {
                "id": "UBE2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P49459",
                "type": "external"
            }
        ],
        "mass": 17315.0,
        "length": 152,
        "protein_name": "Ubiquitin-conjugating enzyme E2 A",
        "gene_name": "UBE2A",
        "organism": "Human",
        "refseq_name": "ubiquitin-conjugating enzyme E2 A isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001269090",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269090",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBE2A; RAD6A",
        "gene_names_refseq": "HHR6A; MRXS30; MRXSN; RAD6A; UBC2; UBE2A",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 A; 2.3.2.23; E2 ubiquitin-conjugating enzyme A; HR6A; RAD6 homolog A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; hHR6A",
        "protein_names_refseq": "E2 ubiquitin-conjugating enzyme A; RAD6 homolog A; ubiquitin carrier protein A; ubiquitin-conjugating enzyme E2 A isoform 4; ubiquitin-conjugating enzyme E2A; ubiquitin-protein ligase A",
        "tax_id": 9606,
        "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); syndromic X-linked intellectual disability Nascimento type (Disease Ontology:DOID:0060820); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:7319);  (R-HSA-8866652);  (R-HSA-8866654);  (R-HSA-983168)",
        "pathway_count": 4,
        "publication_count": 156,
        "publication_id_list": "10562279;11062501;11237011;11350924;11740563;11885984;11953320;12646216;14734113;15215855;15215856;15224091;15224092;15571818;16142244;16307923;16337599;16595681;16849449;16868077;16909393;16954532;17108083;17130289;1717990;17580310;17597759;17726030;18316726;18353650;18359941;18662542;18719106;19028597;19208625;19352404;19410543;19452197;19489725;19723507;19851334;19874575;19940261;20061386;20412111;21203937;21329877;21396873;21554508;22021426;22424782;22544926;22592529;2261476;23481700;23685073;24662292;24715725;24807418;24979766;25030448;25170678;25576301;25582440;25645385;25936802;26024233;26086376;26154972;26210183;26216882;26235645;26344566;26350214;26375851;26711259;26992070;27569044;27597759;27600516;27798111;27862975;27920218;28218747;28228285;28514659;28611923;28832583;28834231;28860189;29242379;29331515;29437277;29493099;29508533;29557506;29632711;29786170;29789417;30315122;30410026;30429286;30484775;30524438;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33368912;33392160;33537174;33673493;33691108;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;35051231;35561310;35580925;35613580;36010968;36162503;36215666;36241641;36284347;37938771;38182926;38297121;6277905;6305978;7851534;8010951;8625414;8991089;9380723;9521656;9668046",
        "class_list": "",
        "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (PubMed:16337599, PubMed:20061386, PubMed:23685073, PubMed:25582440, PubMed:38297121). In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination (PubMed:20061386). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (PubMed:16337599). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (PubMed:16337599). Involved in mitophagy by acting as a E2 ubiquitin-conjugating enzyme for PRKN (PubMed:23685073). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (PubMed:38182926). In association with the E3 ubiquitin-protein ligase complex SIFI, inhibits the mitochondrial stress response by acting as a E2 ubiquitin-conjugating enzyme for UBR4 and KCMF1 (PubMed:38297121)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; High resolution backbone structure from nmr, [RefSeq, PubMed]; Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability., [RefSeq, PubMed]; Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes., [RefSeq, PubMed]; The Role of the Reanalysis of Genetic Test Results in the Diagnosis of Dysmorphic Syndrome Caused by Inherited xq24 Deletion including the UBE2A and CXorf56 Genes. Publication Status: Online-Only, [RefSeq, PubMed]; The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFE9;A6NGR2;A6NMF5;B2R7R9;D3DWI1;Q4TTG1;Q96FX4",
        "ec_number_list": [
            {
                "id": "6.2.1.45",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45",
                "type": "external"
            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "6.2.1.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005764 lysosome;GO:0005770 late endosome;GO:0000785 chromatin",
        "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0000086 G2/M transition of mitotic cell cycle;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.7,
        "record_id": "P49459-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P42696-1",
        "uniprot_id": [
            {
                "id": "RBM34_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P42696",
                "type": "external"
            }
        ],
        "mass": 48565.0,
        "length": 430,
        "protein_name": "RNA-binding protein 34",
        "gene_name": "RBM34",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 34 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001333667",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333667",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM34; KIAA0117",
        "gene_names_refseq": "RBM34",
        "protein_names_uniprotkb": "RNA-binding protein 34; RNA-binding motif protein 34",
        "protein_names_refseq": "RNA-binding protein 34 isoform 3; RNA-binding protein 34; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23029)",
        "pathway_count": 1,
        "publication_count": 99,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12429849;17081983;17287340;17525332;18077418;18212344;18669648;19007248;19651622;19664995;19690332;19691289;20068231;21209280;21406692;22424782;22544926;22898188;23186163;23481700;24714562;24715725;25576301;25645385;25810538;25880248;25892735;26154972;26375851;26728094;26992070;27543614;27600516;27846572;27920218;28063628;28228285;28649982;28832583;28834231;28860189;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30524438;30779550;30833945;31154438;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34561969;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771",
        "class_list": "",
        "function": "This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8J7;Q8N2Z8;Q9H5A1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus",
        "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "P42696-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P54277-1",
        "uniprot_id": [
            {
                "id": "PMS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P54277",
                "type": "external"
            }
        ],
        "mass": 105830.0,
        "length": 932,
        "protein_name": "PMS1 protein homolog 1",
        "gene_name": "PMS1",
        "organism": "Human",
        "refseq_name": "PMS1 protein homolog 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_000525",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000525",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMS1; PMSL1",
        "gene_names_refseq": "HNPCC3; MLH2; PMS1; PMSL1; hPMS1",
        "protein_names_uniprotkb": "PMS1 protein homolog 1; DNA mismatch repair protein PMS1",
        "protein_names_refseq": "DNA mismatch repair protein PMS1; PMS1 postmeiotic segregation increased 1; PMS1 protein homolog 1 isoform a; PMS1 protein homolog 1; human homolog of yeast mutL; mismatch repair gene PMSL1; rhabdomyosarcoma antigen MU-RMS-40.10B; rhabdomyosarcoma antigen MU-RMS-40.10E",
        "tax_id": 9606,
        "disease": "polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); Lynch syndrome (Disease Ontology:DOID:3883)",
        "pathway": " (hsa:5378)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "10480359;10748105;11237011;23481700;24366607;24715725;25418920;25645385;25880248;25892735;26154972;26300262;26929215;26992070;27846572;27920218;28411811;28832583;28904123;29242379;29437277;29493099;29557506;29632046;30315122;30524438;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34211107;34405274;34509645;34561969;34807001;34852986;34932366;35051231;35580925;36010968;36241641;8072530",
        "class_list": "",
        "function": "Analysis of the MLH1, MLH2, MLH6, PMS2 genes and their correlations with clinical data in rectal mucinous adenocarcinoma., [RefSeq, PubMed]; Investigation of discordant sibling pairs from hereditary breast cancer families and analysis of a rare PMS1 variant., [RefSeq, PubMed]; Probably involved in the repair of mismatches in DNA., [UniProtKB, PubMed]; This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPI1;Q4VAL4;Q5FBZ3;Q5FBZ6;Q5FBZ8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0032300 mismatch repair complex",
        "go_biological_process": "GO:0006298 mismatch repair;GO:0009410 response to xenobiotic stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "P54277-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H0J4-1",
        "uniprot_id": [
            {
                "id": "QRIC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H0J4",
                "type": "external"
            }
        ],
        "mass": 180827.0,
        "length": 1663,
        "protein_name": "Glutamine-rich protein 2",
        "gene_name": "QRICH2",
        "organism": "Human",
        "refseq_name": "glutamine-rich protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_115510",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115510",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "QRICH2",
        "gene_names_refseq": "QRICH2; SPGF35",
        "protein_names_uniprotkb": "Glutamine-rich protein 2",
        "protein_names_refseq": "glutamine-rich protein 2 isoform 1; glutamine-rich protein 2",
        "tax_id": 9606,
        "disease": "spermatogenic failure 35 (Disease Ontology:DOID:0111914)",
        "pathway": " (hsa:84074)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11230166;11237011;19367720;29393594;30683861;31292949;32387766;32938616;32983136;33912179;34415320;35051231",
        "class_list": "",
        "function": "Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility., [UniProtKB, PubMed]; Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development., [RefSeq, PubMed]; The findings strongly suggest that the genetic mutations of QRICH2 can lead to male infertility with multiple morphological abnormalities of the flagella, and that QRICH2 is essential for sperm flagellar formation. Erratum:[Nat Commun. 2019 May 20;10(1):2289. doi: 10.1038/s41467-019-10313-x. PMID: 31110204] Publication Status: Online-Only, [RefSeq, PubMed]; Whole exome sequencing of men with multiple morphological abnormalities of the sperm flagella reveals novel homozygous QRICH2 mutations., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRE1;Q96LM3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0036126 sperm flagellum",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:0030031 cell projection assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9H0J4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12829-1",
        "uniprot_id": [
            {
                "id": "RB40B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12829",
                "type": "external"
            }
        ],
        "mass": 30956.0,
        "length": 278,
        "protein_name": "Ras-related protein Rab-40B",
        "gene_name": "RAB40B",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-40B",
        "refseq_ac": [
            {
                "id": "NP_006813",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006813",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAB40B; SEC4L",
        "gene_names_refseq": "RAB40B; RAR; SEC4L",
        "protein_names_uniprotkb": "Ras-related protein Rab-40B; 3.6.5.2; Protein Rar; SOCS box-containing protein RAR",
        "protein_names_refseq": "GTP-binding protein homologous to Saccharomyces cerevisiae SEC4; SOCS box-containing protein RAR; protein Rar; ras-related protein Rab-40B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10966);  (R-HSA-8873719)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "11141079;11237011;11389151;11447212;11675392;16401880;1648736;17114793;17411337;18532927;19603039;22694141;23902685;24023390;25341920;25790780;26969162;27789576;27909076;28218747;29437277;31844290;32157095;32161166;33999101;35293963;36010968;38253038;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8836150",
        "class_list": "",
        "function": "High expression level of Rab40b was significantly correlated with gastric cancer invasion and lymph node metastasis., [RefSeq, PubMed]; RAB40B small GTPase acts as substrate-recognition components of the ECS(RAB40B) E3 ubiquitin ligase complex which mediates the ubiquitination of target proteins (PubMed:33999101, PubMed:35293963). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27789576). As part of the ECS(RAB40B) complex, GTP-bound RAB40B promotes LIMA1/EPLIN ubiquitination and degradation, thereby regulating leading-edge actin dynamics during cell migration (PubMed:33999101). As part of the ECS(RAB40B) complex, GTP-bound RAB40B also ubiquitinates RAP2A GTPase which promotes its localization to lamellipodia and activation to drive cell migration. The ECS(RAB40B) complex does not mediate canonical ubiquitin-dependent degradation of RAP2 (PubMed:35293963). RAB40B also binds TKS5/SH3PXD2A effector independently from ECS complex to promote invadopodia-mediated extracellular matrix degradation (PubMed:27789576)., [UniProtKB, PubMed, PubMed, PubMed]; Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration., [RefSeq, PubMed]; Rab40b mediates trafficking of MMP2/9 during invadopodia formation and metastasis of breast cancer cells., [RefSeq, PubMed]; The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]., [RefSeq]; This is the first study that identifies a new Rab40b-Tks5- and miR-204-dependent invadopodia transport pathway that regulates MMP2 and MMP9 secretion, and extracellular matrix remodeling during cancer progression., [RefSeq, PubMed, PubMed]; Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WVG3",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006887 exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q12829-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q00889-1",
        "uniprot_id": [
            {
                "id": "PSG6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q00889",
                "type": "external"
            }
        ],
        "mass": 48814.0,
        "length": 435,
        "protein_name": "Pregnancy-specific beta-1-glycoprotein 6",
        "gene_name": "PSG6",
        "organism": "Human",
        "refseq_name": "pregnancy-specific beta-1-glycoprotein 6 isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_001027020",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027020",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSG6; CGM3; PSG10; PSG12; PSGGB",
        "gene_names_refseq": "PSBG-10; PSBG-12; PSBG-6; PSG10; PSG6; PSGGB",
        "protein_names_uniprotkb": "Pregnancy-specific beta-1-glycoprotein 6; PS-beta-G-10; PS-beta-G-12; PS-beta-G-6; PSBG-10; PSBG-12; PSBG-6; Pregnancy-specific beta-1-glycoprotein 10; Pregnancy-specific beta-1-glycoprotein 12; Pregnancy-specific glycoprotein 10; Pregnancy-specific glycoprotein 12; Pregnancy-specific glycoprotein 6",
        "protein_names_refseq": "PS-beta-G-10; PS-beta-G-12; PS-beta-G-6; pregnancy-specific beta-1-glycoprotein 10; pregnancy-specific beta-1-glycoprotein 12; pregnancy-specific beta-1-glycoprotein 6 isoform b precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5675);  (R-HSA-202733)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "10606205;10686536;10764623;11207550;11237011;11256994;11564780;11779189;11812992;12070135;12208882;12469115;12782713;14529530;14615387;15000751;15528364;15681301;15721307;1591491;16258728;16297198;16585556;16691243;16737840;16783819;1690992;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;19279206;21193412;21659548;2271648;2346748;2377620;23945545;24043627;24764293;2537643;2538457;2783133;32938616;35051231;468991;7509040;7521878;8163559;8166770;8314844;9052782;9169774;9242610;9295288;9382878;9693095;9763524",
        "class_list": "",
        "function": "This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75244;Q15224;Q15235;Q549K1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q00889-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BUI4-1",
        "uniprot_id": [
            {
                "id": "RPC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BUI4",
                "type": "external"
            }
        ],
        "mass": 60612.0,
        "length": 534,
        "protein_name": "DNA-directed RNA polymerase III subunit RPC3",
        "gene_name": "POLR3C",
        "organism": "Human",
        "refseq_name": "DNA-directed RNA polymerase III subunit RPC3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001290385",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290385",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POLR3C",
        "gene_names_refseq": "C82; POLR3C; RPC3; RPC62",
        "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC3; DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kDa subunit; RNA polymerase III subunit C3; RPC62",
        "protein_names_refseq": "DNA-directed III 62 kDa polypeptide; DNA-directed RNA polymerase III subunit C; DNA-directed RNA polymerase III subunit RPC3 isoform 2; DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III 62 kDa subunit; RNA polymerase III subunit C3; polymerase (RNA) III (DNA directed) polypeptide C (62kD); polymerase (RNA) III subunit C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10623);  (R-HSA-1834949);  (R-HSA-73780);  (R-HSA-73980);  (R-HSA-749476);  (R-HSA-76061);  (R-HSA-76066);  (R-HSA-76071)",
        "pathway_count": 8,
        "publication_count": 117,
        "publication_id_list": "10421633;10523658;11056176;11118217;11237011;11416169;11419933;11463379;12381659;12384934;12391170;18669648;19158675;19158676;19158679;1946469;19609254;19631370;20068231;20413673;21358628;21398614;23251783;23388631;23481700;2404611;24107381;24714562;24715725;25576301;25645385;25880248;25892735;26375851;26394183;26992070;27600516;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30429286;30484775;30524438;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33335104;33392160;33537174;33558764;33558766;33592498;33674783;33717175;33912179;33968037;33981976;34087483;34171305;34185709;34405274;34509645;34675218;34725712;35051231;35318648;35580925;35637192;36010968;36215666;36241641;36284347;37938771;7568218;7891697;7995525;8035818;8308883;8407894;8423814;9003788;9171375;9234698;9312031;9418884;9660958",
        "class_list": "",
        "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15317;Q9Y3R6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:0003899 DNA-directed RNA polymerase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005666 RNA polymerase III complex",
        "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0045089 positive regulation of innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "Q9BUI4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P07225-1",
        "uniprot_id": [
            {
                "id": "PROS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P07225",
                "type": "external"
            }
        ],
        "mass": 75123.0,
        "length": 676,
        "protein_name": "Vitamin K-dependent protein S",
        "gene_name": "PROS1",
        "organism": "Human",
        "refseq_name": "vitamin K-dependent protein S isoform 2 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000304",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000304",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROS1; PROS",
        "gene_names_refseq": "PROS1; PROS; PS21; PS22; PS23; PS24; PS25; PSA; THPH5; THPH6",
        "protein_names_uniprotkb": "Vitamin K-dependent protein S",
        "protein_names_refseq": "protein S (alpha); protein Sa; vitamin K-dependent plasma protein S; vitamin K-dependent protein S isoform 2 preproprotein",
        "tax_id": 9606,
        "disease": "autosomal dominant thrombophilia due to protein S deficiency (Disease Ontology:DOID:0111900); autosomal recessive thrombophilia due to protein S deficiency (Disease Ontology:DOID:0111905); protein S deficiency (Disease Ontology:DOID:2451); cerebral infarction (Disease Ontology:DOID:3526)",
        "pathway": " (hsa:5627);  (R-HSA-114608);  (R-HSA-159740);  (R-HSA-159763);  (R-HSA-159782);  (R-HSA-202733);  (R-HSA-9769735);  (R-HSA-9769739);  (R-HSA-9769743);  (R-HSA-977606);  (R-HSA-9918485);  (R-HSA-9930449);  (R-HSA-9930479)",
        "pathway_count": 13,
        "publication_count": 322,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10.1038/emboj.2013.79;10026158;10068650;10447256;10531307;10606205;10613647;1067618;10706858;10764623;10790208;10917896;11035113;11207550;11237011;11238108;11252894;11256994;11337487;11342438;11372770;11513608;11564780;11694537;11776305;11779189;11812992;11833835;11858485;11927129;11939578;12052963;12055245;12070135;12208882;12351389;12469115;12632031;12682107;12782713;12907439;1386357;1435334;14529530;14615387;14630798;14695241;14982929;15000751;15098107;15147381;15238143;15297306;15507651;15528364;15681301;15712227;15721307;15838506;1591491;15952784;16079145;16161994;1618828;16192651;16258728;16297198;16335952;16585556;16619025;16691243;16737840;16783819;16959974;16999828;17064312;17099249;17116209;17167768;17172599;17182573;17322099;17379836;17442946;17452516;17505016;17505110;17506785;17525755;17563375;17580308;17598008;17600130;17615384;17625065;17635713;18266465;18322254;1874730;1902833;19279206;19297154;1930190;20004170;2019570;2040636;20427285;20484936;2104832;2110473;21107324;21193412;2143091;2148110;2148111;21659548;21788512;21932952;22144186;2248955;22618708;22652793;2271516;22786881;22802338;22898188;22961984;23006890;23021219;23084921;23487775;23584533;23621622;23640497;23658209;23683607;2384594;23945545;24043627;24074594;2420889;24554904;2465906;2466593;24764293;2481448;2502206;2505252;2526663;2538457;25548167;25576301;25645385;25713144;25753038;25855704;26056282;26154972;26212330;26468529;26473492;2664828;26992070;2704749;271951;2738071;27535533;27600516;27832191;28035807;2820795;28832583;29223926;293688;293746;29393594;29419409;29437578;2944113;29557506;2956252;29610346;29671580;2971659;29742433;301546;3017409;30459171;3052293;30779550;3082357;30918026;31003762;31154438;31262782;3129422;3134349;31439947;31611695;31720911;31844290;31848261;32157095;32350084;32387766;32488085;3275472;32897882;32938616;33537174;33592498;33912179;33968037;33981976;34087483;34171305;34357683;34411563;34509645;34561969;3467362;35051231;3524673;35251023;3527261;35580925;36010968;36215666;36241641;36951953;3733688;3744129;37726033;37925034;37938771;38469768;3848661;38575045;38613800;3863104;4098172;468991;6214588;6219696;6222381;6230668;6238120;6323392;6334079;6334516;6438527;6454142;6457647;6607952;670886;6906228;6967872;6980899;702059;7391570;7482398;7499257;7509040;7521878;7542572;7545463;7579449;760802;761607;7688369;7690834;7691959;7727775;7756647;7803790;8144529;8148489;8163559;8164741;8166770;8298131;8314844;8336730;8338946;8345200;8467233;8473289;8495193;8530480;8578528;8598903;8626656;8639673;8639781;8639833;8701404;8765219;8781426;8786315;8943854;8977443;9031443;9038722;9052782;9169774;9218519;9241758;9242610;9295288;9382878;9454742;9459334;9469622;9607108;9693095;9763524;9774404;978134;9834200;9888880;9931503",
        "class_list": "",
        "function": "Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily., [RefSeq, PubMed]; PROS1 is a crucial gene in the macrophage efferocytosis of diabetic foot ulcers: a concerted analytical approach through the prisms of computer analysis., [RefSeq, PubMed]; The Protein S Erlangen Mutation PROS1c.1904T>C (F635S) Suppresses Secretion., [RefSeq, PubMed]; This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 4,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAC9;D3DN28;Q15518;Q7Z715;Q9UCZ8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004866 endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0050819 negative regulation of coagulation",
        "synthesized_glycan_count": 0,
        "hit_score": 33.4,
        "record_id": "P07225-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15434-1",
        "uniprot_id": [
            {
                "id": "RBMS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15434",
                "type": "external"
            }
        ],
        "mass": 43959.0,
        "length": 407,
        "protein_name": "RNA-binding motif, single-stranded-interacting protein 2",
        "gene_name": "RBMS2",
        "organism": "Human",
        "refseq_name": "RNA-binding motif, single-stranded-interacting protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_002889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBMS2; SCR3",
        "gene_names_refseq": "RBMS2; SCR3",
        "protein_names_uniprotkb": "RNA-binding motif, single-stranded-interacting protein 2; Suppressor of CDC2 with RNA-binding motif 3",
        "protein_names_refseq": "RNA-binding motif, single-stranded-interacting protein 2 isoform 1; suppressor of CDC2 with RNA-binding motif 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5939)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11237011;18669648;18691976;19413330;19415658;19664995;19690332;20068231;22121020;23186163;25576301;26992070;27397612;27600516;28832583;28834231;29237092;29242379;29393594;29557506;29786170;29789417;30059200;30429286;30514345;30833945;31373491;31492838;32157095;32488085;32502341;32938616;33214551;33592498;33912179;34019948;35051231;35132862;35254053;35318648;35513511;35580925;36284347;37217939;37340703;37541260;38665916;39531497;39534244;40136647;41350704;8041632",
        "class_list": "",
        "function": "RBMS2 acts as a tumor suppressor in breast cancer and positively regulated the expression of P21 by stabilizing its mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0006396 RNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q15434-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48556-1",
        "uniprot_id": [
            {
                "id": "PSMD8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48556",
                "type": "external"
            }
        ],
        "mass": 39612.0,
        "length": 350,
        "protein_name": "26S proteasome non-ATPase regulatory subunit 8",
        "gene_name": "PSMD8",
        "organism": "Human",
        "refseq_name": "26S proteasome non-ATPase regulatory subunit 8",
        "refseq_ac": [
            {
                "id": "NP_002803",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002803",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMD8",
        "gene_names_refseq": "HEL-S-91n; HIP6; HYPF; Nin1p; PSMD8; Rpn12; S14; p31",
        "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; p31",
        "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; 26S proteasome regulatory subunit p31; epididymis secretory sperm binding protein Li 91n; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5714);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 68,
        "publication_count": 1033,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11237011;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12186903;12194817;12198130;12234927;12297295;12351678;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;12912907;12915405;12917689;12917691;12923053;12963847;1317798;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14564014;14585973;14603323;14611647;14625308;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15247232;15257295;15282312;15292211;15300262;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592474;15601839;15611333;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15983046;15987702;16056267;16061793;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16962933;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18692471;18701449;18711132;18716059;18719096;18720373;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;18926707;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19208626;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19617556;19622347;19666503;1968359;19684112;19706539;19729658;19734889;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21136679;21177870;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22265677;22267219;22279049;22286099;22306028;22306998;22318583;2236053;22391301;22422618;22427670;22440753;22466964;22505454;22508986;22537386;22544926;2261476;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22872865;22885700;22897851;22959436;22964642;22982193;23063411;23069990;23112049;23140627;23144924;23159851;23186163;23201271;23217742;23236459;23256519;23274085;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23486064;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23661552;23685075;23719536;23725801;23746841;23824326;23825189;23851460;23867461;23878308;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24298019;24302888;24309468;24366543;24366607;24367090;24493797;24582806;24585635;24636985;24685677;24714562;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25132172;25133187;25152365;25197364;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25505266;25531226;25547115;25576301;25578727;25578875;25584290;25654763;2570070;2570460;25733683;25740432;25793262;25802875;25810538;25880248;25921531;26091038;26117325;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26443277;26460955;26583321;26632597;26778333;26811146;26906416;26942676;26992070;27030794;27137657;27222660;27249176;27342858;27397612;27428775;27466718;27565346;27572267;27846572;27862975;28115426;28132103;28178531;28263418;28317937;28380357;28442575;28598414;28832583;28904123;2898143;29055231;29153394;29233872;29242379;29290612;29356040;29371260;29437277;29450944;2946959;29493099;29526543;29557506;29632312;29717933;29786170;30118680;30244831;30315122;30334692;30334693;30610225;30728908;30779550;30833945;31011209;31154438;31217245;31222486;3129195;31373491;31530632;31546975;31679946;31844290;31848261;31998317;32005965;32157095;32161166;32284348;32293500;32357974;32387766;32488085;32502341;32640524;32672401;32897882;32938616;32981041;32983136;33009401;33141586;33214551;33298915;33392160;33406423;33444648;33537174;33592498;33691108;33717175;33791708;33859744;33909987;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34215617;34315872;34357683;34405274;34509645;34561969;3457471;3472246;34725712;34932366;35051231;35318648;35385574;35561310;35580925;36010968;36198437;36284347;36580660;37349676;37676773;37938771;40596516;40914422;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7621825;7628694;7639698;7799959;7809113;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8107774;8140422;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8626374;8662591;8662795;8670417;8689684;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9380723;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PSMD8 can serve as potential biomarker and therapeutic target of the PSMD family in ovarian cancer: based on bioinformatics analysis and in vitro validation. Publication Status: Online-Only, [RefSeq, PubMed]; The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DX18;Q6P1L7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 103.6,
        "record_id": "P48556-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43490-1",
        "uniprot_id": [
            {
                "id": "PROM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43490",
                "type": "external"
            }
        ],
        "mass": 97202.0,
        "length": 865,
        "protein_name": "Prominin-1",
        "gene_name": "PROM1",
        "organism": "Human",
        "refseq_name": "prominin-1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001139319",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139319",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROM1; MSTP061; PROML1",
        "gene_names_refseq": "AC133; CD133; CORD12; MCDR2; MSTP061; PROM1; PROML1; RP41; STGD4",
        "protein_names_uniprotkb": "Prominin-1; Antigen AC133; Prominin-like protein 1",
        "protein_names_refseq": "AC133 antigen; Retinitis pigmentosa 41, Cone-rod dystrophy 12; antigen AC133; hProminin; hematopoietic stem cell antigen; prominin-1 isoform 2 precursor; prominin-like protein 1",
        "tax_id": 9606,
        "disease": "Stargardt disease 4 (Disease Ontology:DOID:0061239); retinal macular dystrophy 2 (Disease Ontology:DOID:0070517); retinitis pigmentosa 41 (Disease Ontology:DOID:0110376); cone-rod dystrophy 12 (Disease Ontology:DOID:0111019); diabetes mellitus (Disease Ontology:DOID:9351)",
        "pathway": " (hsa:8842);  (R-HSA-9925563)",
        "pathway_count": 2,
        "publication_count": 40,
        "publication_id_list": "10587575;11237011;12042327;17081983;17498271;17605048;17874118;18096722;18654668;19296573;19302789;20818439;21406692;23090970;23569237;24190977;24375541;24556617;26029999;26992070;28832583;29557506;29741879;29760280;30783186;32387766;33109704;35051231;35580925;35947379;36010968;36215666;37074911;38285791;38365731;38727313;38956727;39353897;9389720;9389721",
        "class_list": "",
        "function": "CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma. Publication Status: Online-Only, [RefSeq, PubMed]; CD133, CD47, and PD-L1 Expression in Ovarian High-grade Serous Carcinoma and Its Association with Metastatic Disease: A Cross-sectional Study. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation. Publication Status: Online-Only, [RefSeq, PubMed]; High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad? Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439)., [UniProtKB, PubMed, PubMed]; This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "",
        "glycan_count": 40,
        "disease_count": 5,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6SV49;Q6SV50;Q6SV51;Q6SV52;Q6SV53;Q96EN6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045296 cadherin binding;GO:0042805 actinin binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface",
        "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0045494 photoreceptor cell maintenance;GO:0010842 retina layer formation;GO:0072139 glomerular parietal epithelial cell differentiation;GO:2000768 positive regulation of nephron tubule epithelial cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "O43490-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000110010001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y3B1-1",
        "uniprot_id": [
            {
                "id": "PLD3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y3B1",
                "type": "external"
            }
        ],
        "mass": 21495.0,
        "length": 194,
        "protein_name": "PRELI domain containing protein 3B",
        "gene_name": "PRELID3B",
        "organism": "Human",
        "refseq_name": "PRELI domain containing protein 3B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243332",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243332",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRELID3B; C20orf45; CGI-107; SLMO2",
        "gene_names_refseq": "C20orf45; PRELID3B; SLMO2; UPS2; dJ543J19.5",
        "protein_names_uniprotkb": "PRELI domain containing protein 3B; Protein slowmo homolog 2",
        "protein_names_refseq": "PRELI domain containing protein 3B isoform 2; PRELI domain containing protein 3B; protein slowmo homolog 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51012)",
        "pathway_count": 1,
        "publication_count": 72,
        "publication_id_list": "11237011;17697703;19413330;20877624;22645359;22706990;23481700;24366607;24714562;25576301;25645385;26024233;26154972;26728094;26992070;27600516;27846572;27920218;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29786170;29789417;30315122;30410026;30429286;30484775;30779550;30850607;31092671;31154438;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34561969;35318648;35561310;35580925;36215666;36241641;36284347;38212657",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; SLMO2 is a potential prognostic and immunological biomarker in human pan-cancer. Erratum:[Sci Rep. 2024 Mar 13;14(1):6087. doi: 10.1038/s41598-024-55384-z. PMID: 38480750] Publication Status: Online-Only, [RefSeq, PubMed]; Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins has been reported. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5I8;Q5JX17;Q9NUL0",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space",
        "go_biological_process": "GO:0015914 phospholipid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q9Y3B1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UL46-1",
        "uniprot_id": [
            {
                "id": "PSME2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UL46",
                "type": "external"
            }
        ],
        "mass": 27402.0,
        "length": 239,
        "protein_name": "Proteasome activator complex subunit 2",
        "gene_name": "PSME2",
        "organism": "Human",
        "refseq_name": "proteasome activator complex subunit 2",
        "refseq_ac": [
            {
                "id": "NP_002809",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002809",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSME2",
        "gene_names_refseq": "PA28B; PA28beta; PSME2; REGbeta",
        "protein_names_uniprotkb": "Proteasome activator complex subunit 2; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; PA28beta; PA28b; Proteasome activator 28 subunit beta; REG-beta",
        "protein_names_refseq": "11S regulator complex beta subunit; 11S regulator complex subunit beta; MCP activator, 31-kD subunit; REG-beta; activator of multicatalytic protease subunit 2; cell migration-inducing protein 22; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); proteasome activator 28 subunit beta; proteasome activator 28-beta; proteasome activator complex subunit 2; proteasome activator hPA28 subunit beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5721);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-8950505);  (R-HSA-9907900);  (R-HSA-9912633)",
        "pathway_count": 6,
        "publication_count": 118,
        "publication_id_list": "10199920;10973495;11237011;11350924;12061891;15118850;15592474;15831487;15944226;16038020;16251969;16408927;16818754;16990800;17145369;17189198;17323924;17377532;17540904;17948026;18249105;18692471;19217269;19317650;19413330;19490896;19615748;20028659;20068231;20471946;22153078;22424782;22544926;23186163;23481700;23613522;24715725;25083866;25418920;25576301;25645385;25892735;26154972;26375851;26768311;26811146;26929215;26992070;27655845;27846572;27920218;28063628;28228285;28263418;28442575;28467828;28510447;28598414;28855257;28904123;29317506;29437277;29493099;29557506;29632046;30315122;30410026;30484775;31154438;31217245;31611695;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34229054;34357683;34405274;34509645;34561969;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38385075;40914422;40930100;7789512",
        "class_list": "",
        "function": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PSME2 offers value as a biomarker of M1 macrophage infiltration in pan-cancer and inhibits osteosarcoma malignant phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15129",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0061133 endopeptidase activator activity",
        "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006979 response to oxidative stress;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.1,
        "record_id": "Q9UL46-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96A00-1",
        "uniprot_id": [
            {
                "id": "PP14A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96A00",
                "type": "external"
            }
        ],
        "mass": 16693.0,
        "length": 147,
        "protein_name": "Protein phosphatase 1 regulatory subunit 14A",
        "gene_name": "PPP1R14A",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 14A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001230876",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230876",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP1R14A; CPI17; PPP1INL",
        "gene_names_refseq": "CPI-17; CPI17; PPP1INL; PPP1R14A",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; CPI-17; Protein kinase C-potentiated inhibitor protein of 17 kDa",
        "protein_names_refseq": "17 kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; PKC-potentiated inhibitory protein of PP1; protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory subunit 14A isoform 2; protein phosphatase 1 regulatory subunit 14A",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534)",
        "pathway": " (hsa:94274);  (R-HSA-5625740)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10330186;10619026;10744661;10753910;10869555;10924361;11134534;11237011;11287002;11313932;11331307;11467857;11517233;11734001;11942626;11943207;12144526;12359219;12595264;12604330;12783890;12804574;12974676;14514689;15003508;15184667;15665049;15791647;16472257;17200564;17301291;18006505;18088087;18835557;19413330;19651622;19723632;20068231;21351730;21406692;21749319;23186163;23541585;24128008;25980620;30428734;31789805;32471307;34019948;34509645;34849858;35418530;35580925;38474189;38887993;8662509;9278512;9354661;9889122;9988689",
        "class_list": "",
        "function": "CPI-17 Overexpression and Its Correlation With the NF2 Mutation Spectrum in Sporadic Vestibular Schwannomas., [RefSeq, PubMed]; Inhibitor of PPP1CA., [UniProtKB, UniProtKB, UniProtKB]; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction., [UniProtKB, UniProtKB, UniProtKB]; Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation., [RefSeq, PubMed]; PPP1R14A is Associated with Immunotherapy Resistance in Head and Neck Squamous Cell Carcinoma Identified by Single-Cell and Bulk RNA-Sequencing., [RefSeq, PubMed]; Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death. Publication Status: Online-Only, [RefSeq, PubMed]; The down-regulated expression of CPI-17 phosphorylated proteins might be one of the important factors of uterine atony-induced postpartum hemorrhage., [RefSeq, PubMed]; The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z4X7;Q96S54",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q96A00-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P46060-1",
        "uniprot_id": [
            {
                "id": "RAGP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P46060",
                "type": "external"
            }
        ],
        "mass": 63542.0,
        "length": 587,
        "protein_name": "Ran GTPase-activating protein 1",
        "gene_name": "RANGAP1",
        "organism": "Human",
        "refseq_name": "ran GTPase-activating protein 1",
        "refseq_ac": [
            {
                "id": "NP_001265580",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265580",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RANGAP1; KIAA1835; SD",
        "gene_names_refseq": "Fug1; RANGAP1; RANGAP; SD",
        "protein_names_uniprotkb": "Ran GTPase-activating protein 1; RanGAP1",
        "protein_names_refseq": "ran GTPase-activating protein 1; segregation distorter homolog",
        "tax_id": 9606,
        "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)",
        "pathway": " (hsa:5905);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-165054);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-4615885);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9615933);  (R-HSA-9648025);  (R-HSA-9793242)",
        "pathway_count": 12,
        "publication_count": 250,
        "publication_id_list": "10.1101/2023.09.13.557529;10411507;10600384;10678165;10759568;10862613;10911995;10958683;11081627;11181178;11231159;11237011;11371342;11509732;11535616;11709553;11804586;11836381;11854305;12006501;12149243;12194817;12429848;12577064;12679384;12732141;12805219;12832072;12852857;14729961;14730319;15006353;15037602;15085137;15302935;15339662;15507212;15723797;15737063;15864301;15866170;15931174;15931224;15944396;15989970;16292343;16428860;16439214;16541025;16565220;16622419;16622420;16682347;16890222;16943183;17030981;17081983;17098863;17099698;17112726;17113138;17129783;17183683;17196341;17198702;17235358;1737036;17693683;18001770;18093978;18097444;18316408;18381449;18394993;18452278;18477386;18669648;18691969;18716626;18923426;18946085;19350017;19413330;19415658;1944575;19596686;19608861;19651622;19664995;19690332;19696148;19815554;19965387;20030946;20068230;20068231;20101212;20388717;20591975;20663916;20953181;20974814;21111234;21148482;21167178;21397845;21406692;21554500;21576392;21868368;21878504;21987589;22094460;22194619;22275430;22424782;22457066;22464730;22544926;22608513;22790947;22885700;22898188;23186163;23222643;23481700;23801653;24366607;24715725;24782567;24914801;25114211;25218447;25505266;25576301;25602437;25645385;25723178;25740311;25755297;25772364;25789526;25892735;26154972;26304119;26375851;26768311;26811146;26992070;27160050;27600516;27846572;27862975;27893789;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30429286;30524438;31217245;31409757;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34260926;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;36696903;36916534;37217939;37845585;37938771;38665916;38801243;40596516;40914422;7878053;7891706;7958838;8146159;8805303;8896452;8973340;9019411;9497385;9649308;9649503;9837918;9892021",
        "class_list": "",
        "function": "GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis., [RefSeq, PubMed]; Impact of RANGAP1 SUMOylation on Smad4 nuclear export by bioinformatic analysis and cell assays. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma., [RefSeq, PubMed]; SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS., [RefSeq, PubMed]; This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96JJ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005096 GTPase activator activity;GO:0045296 cadherin binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction;GO:0016925 protein sumoylation;GO:0051168 nuclear export;GO:0090630 activation of GTPase activity;GO:0046826 negative regulation of protein export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 25.7,
        "record_id": "P46060-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15008-1",
        "uniprot_id": [
            {
                "id": "PSMD6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15008",
                "type": "external"
            }
        ],
        "mass": 45531.0,
        "length": 389,
        "protein_name": "26S proteasome non-ATPase regulatory subunit 6",
        "gene_name": "PSMD6",
        "organism": "Human",
        "refseq_name": "26S proteasome non-ATPase regulatory subunit 6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001258708",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258708",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMD6; KIAA0107; PFAAP4",
        "gene_names_refseq": "PSMD6; Rpn7; S10; SGA-113M; p42A; p44S10",
        "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 6; 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4; Proteasome regulatory particle subunit p44S10; p42A",
        "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 6 isoform 1; 26S proteasome non-ATPase regulatory subunit 6; breast cancer-associated protein SGA-113M; phosphonoformate immuno-associated protein 4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 6; proteasome regulatory particle subunit p44S10",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:9861);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-6798695);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 69,
        "publication_count": 1032,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10723133;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11237011;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12186903;12194817;12198130;12234927;12297295;12351678;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;12912907;12915405;12917689;12917691;12923053;12963847;1317798;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14564014;14585973;14603323;14611647;14625308;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15247232;15257295;15282312;15292211;15300262;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592474;15601839;15611333;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15983046;15987702;16056267;16061793;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16408927;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16962933;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18692471;18701449;18711132;18716059;18719096;18720373;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;18926707;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19208626;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19617556;19622347;19666503;1968359;19684112;19706539;19729658;19734889;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20068231;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21177870;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22223895;22265677;22267219;22279049;22286099;22306028;22306998;22318583;2236053;22391301;22422618;22427670;22440753;22466964;22505454;22508986;22537386;2261476;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22869377;22872865;22885700;22897851;22959436;22964642;22982193;23063411;23069990;23112049;23140627;23144924;23159851;23201271;23217742;23236459;23256519;23274085;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23481700;23486064;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23650620;23661552;23685075;23719536;23725801;23746841;23824326;23825189;23851460;23867461;23878308;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24298019;24302888;24309468;24366543;24367090;24493797;24582806;24585635;24636985;24685677;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25132172;25133187;25152365;25197364;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25531226;25547115;25576301;25578727;25578875;25584290;25645385;25654763;2570070;2570460;25733683;25740432;25793262;25892735;25921531;26091038;26117325;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26375851;26443277;26460955;26583321;26632597;26778333;26906416;26942676;26992070;27030794;27137657;27222660;27249176;27342858;27428775;27466718;27565346;27572267;27600516;27920218;28115426;28132103;28178531;28218747;28228285;28263418;28317937;28380357;28442575;28510447;28598414;28832583;28834231;28855257;28904123;2898143;29055231;29153394;29233872;29242379;29331515;29356040;29393594;29437277;29450944;2946959;29493099;29508533;29526543;29557506;29632312;29717933;29769354;29786170;29789417;30118680;30244831;30315122;30334692;30334693;30429286;30610225;30728908;31011209;31092671;31217245;3129195;31546975;31679946;31844290;32005965;32157095;32161166;32284348;32293500;32350084;32387766;32488085;32502341;32640524;32672401;32897882;32938616;32981041;32983136;33009401;33141586;33392160;33406423;33444648;33537174;33592498;33633747;33691108;33717175;33791708;33859744;33909987;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34215617;34315872;34357683;34509645;34561969;3457471;3472246;34725712;34932366;35051231;35138101;35251023;35318648;35385574;35494241;35580925;36010968;36198437;36284347;36580660;36581221;37676773;37938771;38665916;39534244;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7628694;7639698;7799959;7809113;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8107774;8140422;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8626374;8662591;8662795;8670417;8689684;8692836;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9380723;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, PubMed]; This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2E0;E9PHI9;Q6UV22",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0034774 secretory granule lumen",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 103.6,
        "record_id": "Q15008-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NUQ2-1",
        "uniprot_id": [
            {
                "id": "PLCE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NUQ2",
                "type": "external"
            }
        ],
        "mass": 42072.0,
        "length": 364,
        "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon",
        "gene_name": "AGPAT5",
        "organism": "Human",
        "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon",
        "refseq_ac": [
            {
                "id": "NP_060831",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060831",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "AGPAT5",
        "gene_names_refseq": "1AGPAT5; AGPAT5; LPAATE; LPLAT5",
        "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-AGP acyltransferase 5; 1-AGPAT 5; 1-acylglycerol-3-phosphate O-acyltransferase 5; 2.3.1.51; LPAAT-epsilon; Lysophosphatidic acid acyltransferase epsilon",
        "protein_names_refseq": "1-AGP acyltransferase 5; 1-AGPAT 5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon); lysophosphatidic acid acyltransferase epsilon; lysophospholipid acyltransferase 5; testicular tissue protein Li 144",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55326);  (R-HSA-1483166)",
        "pathway_count": 2,
        "publication_count": 122,
        "publication_id_list": "10455175;10506173;10553003;10681567;11031251;11112443;11230166;11237011;11788596;11830583;12063250;12161451;12359733;12522102;12963729;14573790;15367102;16460752;16495223;16620771;16704971;16864775;17028579;17170135;17707131;18238778;18718904;19336658;19666841;20705608;20877624;21173190;22424782;22617051;22777291;22922100;23176821;23176823;23481700;23807634;24366607;24714562;24715725;24966474;25418920;25576301;25892735;26154972;26375851;26711011;26728094;26992070;27846572;27893789;28063628;28218747;28228285;28446606;28514659;28832583;28855257;28904123;29242379;2925608;29393594;29437277;29493099;29557506;29632046;29632711;29769354;30315122;30524438;30779550;31020640;31092671;31154438;31217245;31222486;31844290;31848261;31937595;32157095;32161166;32265295;32357974;32387766;32502341;32938616;32983136;33141586;33298915;33392160;33717175;33912179;33936100;33968037;33981976;34087483;34211107;34357683;34405274;34509645;3458202;34932366;35051231;35561310;36241641;36284347;36581221;37938771;7060561;7821823;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9461603;9582313",
        "class_list": "",
        "function": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190)., [UniProtKB, PubMed]; Enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]., [RefSeq]; This publication describes the molecular cloning, tissue distribution, and enzyme characterization of the mouse homolog, mAGPAT5., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IZ47;Q9BQG4",
        "ec_number_list": [
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15",
                "type": "external"
            },
            {
                "id": "2.3.1.121",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.n6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6",
                "type": "external"
            },
            {
                "id": "2.3.1.n7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0008654 phospholipid biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q9NUQ2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q06203-1",
        "uniprot_id": [
            {
                "id": "PUR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q06203",
                "type": "external"
            }
        ],
        "mass": 57399.0,
        "length": 517,
        "protein_name": "Amidophosphoribosyltransferase",
        "gene_name": "PPAT",
        "organism": "Human",
        "refseq_name": "amidophosphoribosyltransferase",
        "refseq_ac": [
            {
                "id": "NP_002694",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002694",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPAT; GPAT",
        "gene_names_refseq": "ATASE; GPAT; PPAT; PRAT",
        "protein_names_uniprotkb": "Amidophosphoribosyltransferase; 2.4.2.14; ATase; GPAT; Glutamine phosphoribosylpyrophosphate amidotransferase",
        "protein_names_refseq": "amidophosphoribosyltransferase; glutamine PRPP amidotransferase; glutamine phosphoribosylpyrophosphatate amidotransferase; glutamine phosphoribosylpyrophosphate amidotransferase",
        "tax_id": 9606,
        "disease": "renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:5471);  (R-HSA-73817)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10513815;10958654;11096114;11237011;11381136;11466336;12450384;14529546;15104674;15786719;1592113;17224163;18388293;18609073;1967654;20068231;21320556;2147474;2183217;21960835;23301498;23481700;24714562;24715725;25418920;25469497;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26929215;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28860189;28904123;29242379;29314611;29331515;29393594;29437277;29508533;29557506;29632046;29769354;29786170;30315122;30484775;30779550;31154438;31530632;31844290;31848261;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33271445;33298915;33592498;33717175;33785613;33912179;33936100;33968037;33981976;34229054;34357683;34509645;34725712;35008409;35051231;35154160;35251023;35798250;36010968;36241641;36581221;38665916;40914422;4348202;4726295;762062;7706277;7903306;8089153;8106516;8110788;8366112;8380692;8567683;9045906",
        "class_list": "",
        "function": "Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine., [UniProtKB, UniProtKB]; Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Review article, [RefSeq, PubMed]; SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT., [RefSeq, PubMed]; Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.4.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004044 amidophosphoribosyltransferase activity;GO:0016740 transferase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0009113 purine nucleobase biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "Q06203-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96LT9-1",
        "uniprot_id": [
            {
                "id": "RNPC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96LT9",
                "type": "external"
            }
        ],
        "mass": 58575.0,
        "length": 517,
        "protein_name": "RNA-binding region-containing protein 3",
        "gene_name": "RNPC3",
        "organism": "Human",
        "refseq_name": "RNA-binding region-containing protein 3",
        "refseq_ac": [
            {
                "id": "NP_060089",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060089",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNPC3; KIAA1839; RBM40; RNP; SNRNP65",
        "gene_names_refseq": "CPHD7; IGHD5; RBM40; RNPC3; RNP; SNRNP65",
        "protein_names_uniprotkb": "RNA-binding region-containing protein 3; RNA-binding motif protein 40; RNA-binding protein 40; U11/U12 small nuclear ribonucleoprotein 65 kDa protein; U11/U12 snRNP 65 kDa protein; U11/U12-65K",
        "protein_names_refseq": "RNA-binding motif protein 40; RNA-binding protein 40; RNA-binding region-containing protein 3; U11/U12 small nuclear ribonucleoprotein 65 kDa protein; U11/U12 snRNP 65 kDa protein; U11/U12 snRNP 65K; U11/U12-65K",
        "tax_id": 9606,
        "disease": "combined or isolated pituitary growth hormone deficiency 7 (Disease Ontology:DOID:0061016)",
        "pathway": " (hsa:55599);  (R-HSA-72165)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "10207048;11237011;11333026;11607023;14974681;15146077;16096647;17081983;17940139;18452278;19052544;19447915;20068231;23186163;23301498;24275569;24480542;2524422;25418920;25645385;26154972;27510544;28228285;29255062;29557506;30315122;30410026;31154438;31844290;32357974;32387766;32462814;32502341;32938616;33141586;33298915;33650182;33968037;34509645;34906446;35051231;35580925;36010968;37463572;8835860",
        "class_list": "",
        "function": "A Novel RNPC3 Gene Variant Expands the Phenotype in Patients with Congenital Hypopituitarism and Neuropathy., [RefSeq, PubMed]; Establishing intellectual disability as the key feature of patients with biallelic RNPC3 variants., [RefSeq, PubMed]; Expanding the phenotype of biallelic RNPC3 variants associated with growth hormone deficiency. Erratum:[EMBO Mol Med. 2020 Sep 7;12(9):e13132. doi: 10.15252/emmm.202013132. PMID: 32893466], [RefSeq, PubMed]; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency., [RefSeq, PubMed]; Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. [provided by RefSeq, Jul 2008]., [RefSeq]; U11/U12-65K contribute to di-snRNP formation and intron bridging in the minor prespliceosome, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1C9;D3DT74;Q5TZ87;Q96FK7;Q96JI8;Q9NSU7;Q9NXX2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030626 U12 snRNA binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005689 U12-type spliceosomal complex",
        "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q96LT9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NXH3-1",
        "uniprot_id": [
            {
                "id": "PP14D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NXH3",
                "type": "external"
            }
        ],
        "mass": 16508.0,
        "length": 145,
        "protein_name": "Protein phosphatase 1 regulatory subunit 14D",
        "gene_name": "PPP1R14D",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 14D isoform 1",
        "refseq_ac": [
            {
                "id": "NP_060196",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060196",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP1R14D; GBPI",
        "gene_names_refseq": "CPI17-like; GBPI-1; GBPI1; PPP1R14D",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14D; GBPI-1; Gastrointestinal and brain-specific PP1-inhibitory protein 1",
        "protein_names_refseq": "PKC-dependent PP1 inhibitory protein; gastrointestinal and brain-specific PP1-inhibitory protein 1; gut and brain phosphatase inhibitor 1; protein phosphatase 1 regulatory subunit 14D isoform 1; protein phosphatase 1 regulatory subunit 14D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54866)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;12974676;29557506;36263632",
        "class_list": "",
        "function": "A gastrointestinal- and brain-specific PP1 inhibitory protein (GBPI-1)is activated by PKC phosphorylation. A longer GBPI-2 splice variant mRNA is found in testes., [RefSeq, PubMed]; Inhibitor of PPP1CA., [UniProtKB, UniProtKB]; Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction., [UniProtKB, PubMed]; PPP1R14D promotes the proliferation, migration and invasion of lung adenocarcinoma via the PKCalpha/BRAF/MEK/ERK signaling pathway., [RefSeq, PubMed]; Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4V773",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q9NXH3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P26374-1",
        "uniprot_id": [
            {
                "id": "RAE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P26374",
                "type": "external"
            }
        ],
        "mass": 74071.0,
        "length": 656,
        "protein_name": "Rab proteins geranylgeranyltransferase component A 2",
        "gene_name": "CHML",
        "organism": "Human",
        "refseq_name": "rab proteins geranylgeranyltransferase component A 2",
        "refseq_ac": [
            {
                "id": "NP_001812",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001812",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CHML; REP2",
        "gene_names_refseq": "CHML; REP2",
        "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A 2; Choroideremia-like protein; REP-2; Rab escort protein 2",
        "protein_names_refseq": "CHM like Rab escort protein 2; choroideraemia-like protein; choroideremia-like (Rab escort protein 2); choroideremia-like protein; rab proteins geranylgeranyltransferase component A 2",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841); choroideremia (Disease Ontology:DOID:9821)",
        "pathway": " (hsa:1122);  (R-HSA-8873719);  (R-HSA-8876198)",
        "pathway_count": 3,
        "publication_count": 236,
        "publication_id_list": "10818110;10990452;11038176;11141079;11179213;11237011;11389151;11447212;11516400;11675392;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12242008;12244319;12356470;12364329;12427552;12475894;12684051;12944476;12972505;1301160;15096524;15138286;1516130;15186776;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16401880;16410077;1648736;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17114793;17132146;17189207;17208202;17239822;17287728;17411337;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18344558;18354496;18367545;1845915;18477474;18532927;18559336;18585354;18664496;18669648;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19603039;19620288;19626040;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22694141;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23301498;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24023390;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25418920;25472813;25648148;25713415;25880248;25925668;26055712;26177209;26245486;26434594;26538022;26925400;26936971;26969162;27041585;27044746;27103185;27246931;27329675;28834231;29393594;29632046;30379171;30833945;31175290;31611695;31844290;32265295;32488085;32502341;32897882;32938616;33968037;34171305;34357683;34649053;34932366;35051231;35184380;7688123;7911226;7957092;7991565;8144603;8164745;8294464;8349690;8375503;8408203;8513495;8522602;8631982;8662963;8836150;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "CHML is an NRF2 target gene that regulates mTOR function., [RefSeq, PubMed]; CHML promotes migration, invasion and metastasis of hepatocellular carcinoma cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Publication Status: Online-Only, [RefSeq, PubMed]; CHML targeted by miR-199a-3p promotes non-small cell lung cancer cell growth via binding to Rab5A. Erratum:[Pathol Res Pract. 2022 Jan;229:153698. doi: 10.1016/j.prp.2021.153698. PMID: 34826741], [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family., [UniProtKB, PubMed, PubMed, PubMed]; The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAB9;Q17RE0;Q9H1Y4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex;GO:0016020 membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0018344 protein geranylgeranylation",
        "synthesized_glycan_count": 0,
        "hit_score": 23.9,
        "record_id": "P26374-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q06323-1",
        "uniprot_id": [
            {
                "id": "PSME1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q06323",
                "type": "external"
            }
        ],
        "mass": 28723.0,
        "length": 249,
        "protein_name": "Proteasome activator complex subunit 1",
        "gene_name": "PSME1",
        "organism": "Human",
        "refseq_name": "proteasome activator complex subunit 1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001268457",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268457",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSME1; IFI5111",
        "gene_names_refseq": "HEL-S-129m; IFI5111; PA28A; PA28alpha; PSME1; REGalpha",
        "protein_names_uniprotkb": "Proteasome activator complex subunit 1; 11S regulator complex subunit alpha; Activator of multicatalytic protease subunit 1; IGUP I-5111; Interferon gamma up-regulated I-5111 protein; PA28alpha; PA28a; Proteasome activator 28 subunit alpha; REG-alpha",
        "protein_names_refseq": "11S regulator complex subunit alpha; 29-kD MCP activator subunit; IGUP I-5111; activator of multicatalytic protease subunit 1; epididymis secretory sperm binding protein Li 129m; interferon gamma up-regulated I-5111 protein; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); proteasome activator complex subunit 1 isoform 3; proteasome activator complex subunit 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5720);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-9907900);  (R-HSA-9912633)",
        "pathway_count": 5,
        "publication_count": 92,
        "publication_id_list": "10199920;10973495;11237011;11350924;12061891;1286667;15592474;15831487;15944226;16251969;16818754;16990800;17189198;17323924;17540904;17948026;18249105;18692471;19217269;19317650;19490896;20028659;20471946;22153078;23301498;23613522;24715725;25083866;25576301;26154972;26992070;27655845;27846572;27862975;28263418;28442575;28467828;28510447;28598414;28832583;28904123;29242379;29493099;29557506;30315122;30429286;30484775;30573663;30779550;30833945;31154438;31217245;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32488085;32897882;32938616;32983136;33091337;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34185709;34211107;34357683;35051231;35132862;35154160;35318648;35580925;36010968;36284347;37938771;8051173;8269930;9385652;9403698;9590240",
        "class_list": "",
        "function": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJG9;H0YNE3;Q6IBM2;Q9UEF4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0061133 endopeptidase activator activity",
        "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006979 response to oxidative stress;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q06323-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96BW5-1",
        "uniprot_id": [
            {
                "id": "PTER_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96BW5",
                "type": "external"
            }
        ],
        "mass": 39018.0,
        "length": 349,
        "protein_name": "N-acetyltaurine hydrolase",
        "gene_name": "PTER",
        "organism": "Human",
        "refseq_name": "N-acetyltaurine hydrolase isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001248767",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001248767",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTER",
        "gene_names_refseq": "HPHRP; PTER; RPR-1",
        "protein_names_uniprotkb": "N-acetyltaurine hydrolase; 3.1.-.-; Phosphotriesterase-related protein",
        "protein_names_refseq": "N-acetyltaurine hydrolase isoform 3; N-acetyltaurine hydrolase; parathion hydrolase-related protein; phosphotriesterase-related protein; resiniferatoxin-binding, phosphotriesterase-related",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9317)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "11237011;19151714;20068231;20712903;22544926;23301498;23481700;24750591;25576301;25645385;25880248;26154972;26375851;28218747;28228285;28832583;29242379;29393594;29437277;29508533;29557506;29632046;29786170;29789417;30315122;30410026;30524438;31154438;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33298915;33936100;33968037;34087483;34171305;34211107;34357683;34509645;35051231;35154160;35580925;36241641;36284347;37699602;37938771;39112712",
        "class_list": "",
        "function": "In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene), near MAF (encoding the transcription factor c-MAF) and near PTER (phosphotriesterase-related gene)., [RefSeq, PubMed]; N-acetyltaurine hydrolase that regulates feeding by catalyzing the hydrolysis of N-acetyltaurine into taurine and acetate (PubMed:39112712). N-acetyltaurine has anorexigenic and anti-obesity effects that are dependent on GFRAL receptor and GDF15 (By similarity). PTER also acts on other N-acetyl amino acids (Met, Ile, Leu, Val) and N-propionyltaurine, but at lower rates (By similarity)., [UniProtKB, PubMed, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Our findings reveal that PTER may sense albuminuria in the progression of Membranous nephropathy induce tubular cell activation and lead to end-stage renal disease . Erratum:[J Biomed Sci. 2016 Apr 04;23:37. doi: 10.1186/s12929-016-0252-5. PMID: 27044255] Publication Status: Online-Only, [RefSeq, PubMed]; PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity., [RefSeq, PubMed]; Phosphotriesterase-related protein as a novel prognostic predictor for hepatocellular carcinoma patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ77;B3KTF5;D3DRU0;Q9BY46",
        "ec_number_list": [
            {
                "id": "3.5.1.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0141215 N-acetyltaurine hydrolase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0032098 regulation of appetite;GO:0019530 taurine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q96BW5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96HA9-1",
        "uniprot_id": [
            {
                "id": "PX11C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96HA9",
                "type": "external"
            }
        ],
        "mass": 26636.0,
        "length": 241,
        "protein_name": "Peroxisomal membrane protein 11C",
        "gene_name": "PEX11G",
        "organism": "Human",
        "refseq_name": "peroxisomal membrane protein 11C isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001257468",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257468",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEX11G; PEX11C",
        "gene_names_refseq": "PEX11G; PEX11gamma",
        "protein_names_uniprotkb": "Peroxisomal membrane protein 11C; PEX11-gamma; Peroxin-11C; Peroxisomal biogenesis factor 11C; Protein PEX11 homolog gamma",
        "protein_names_refseq": "PEX11-gamma; Peroxisomal membrane protein 11G; Pex11pgamma; peroxin Pex11p gamma; peroxin-11C; peroxisomal biogenesis factor 11C; peroxisomal biogenesis factor 11G; peroxisomal membrane protein 11C isoform 2; peroxisomal membrane protein 11C; protein PEX11 homolog gamma",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92960)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;12417726;12559946;20826455;24715725;25892735;29769354",
        "class_list": "",
        "function": "Coordinates peroxisome membrane proliferation and maintenance, [RefSeq, PubMed]; Data show that Pex11pgamma is a peroxisomal membrane protein, with both the N- and C-termini exposed to the cytosol., [RefSeq, PubMed]; Promotes membrane protrusion and elongation on the peroxisomal surface., [UniProtKB, PubMed]; The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NDM0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0016559 peroxisome fission;GO:0044375 regulation of peroxisome size",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q96HA9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P63132-1",
        "uniprot_id": [
            {
                "id": "PO113_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P63132",
                "type": "external"
            }
        ],
        "mass": 108066.0,
        "length": 959,
        "protein_name": "Endogenous retrovirus group K member 113 Pol protein",
        "gene_name": "HERVK_113",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HERVK_113",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 113 Pol protein; HERV-K113 Pol protein; HERV-K_19p13.11 provirus ancestral Pol protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11591322",
        "class_list": "",
        "function": "Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "2.7.7.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "3.1.26.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4",
                "type": "external"
            },
            {
                "id": "3.4.23.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.50",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.7.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006310 DNA recombination;GO:0006261 DNA-templated DNA replication;GO:0015074 DNA integration",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P63132-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10266-1",
        "uniprot_id": [
            {
                "id": "POK10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10266",
                "type": "external"
            }
        ],
        "mass": 114827.0,
        "length": 1014,
        "protein_name": "Endogenous retrovirus group K member 10 Pol protein",
        "gene_name": "ERVK-10",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "ERVK-10",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 10 Pol protein; HERV-K10 Pol protein; HERV-K107 Pol protein; HERV-K_5q33.3 provirus ancestral Pol protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 10,
        "publication_id_list": "10.1101/2023.09.13.557529;10469592;11278433;12060620;3021993;7983737;8506289;8627242;9217052;9860826",
        "class_list": "",
        "function": "Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution., [UniProtKB]; May possess a function in tumorigenesis., [UniProtKB]; Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases., [UniProtKB]; The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 9737,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P87890;Q14273",
        "ec_number_list": [
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "2.7.7.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "3.1.26.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4",
                "type": "external"
            },
            {
                "id": "3.4.23.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.50",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.7.102",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0035613 RNA stem-loop binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005634 nucleus",
        "go_biological_process": "GO:0006310 DNA recombination;GO:0006261 DNA-templated DNA replication;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P10266-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.010000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YR6-1",
        "uniprot_id": [
            {
                "id": "POTED_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YR6",
                "type": "external"
            }
        ],
        "mass": 66394.0,
        "length": 584,
        "protein_name": "POTE ankyrin domain family member D",
        "gene_name": "POTED",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "POTED; A26B3; ANKRD21; POTE",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "POTE ankyrin domain family member D; ANKRD26-like family B member 3; Ankyrin repeat domain-containing protein 21; Prostate, ovary, testis-expressed protein; Protein POTE",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100288966);  (hsa:317754)",
        "pathway_count": 2,
        "publication_count": 7,
        "publication_id_list": "11237011;12475935;15276201;21248752;29557506;31844290;32938616",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JCF7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86YR6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "H0Y7S4-1",
        "uniprot_id": [
            {
                "id": "PRA26_HUMAN",
                "url": "https://www.uniprot.org/uniprot/H0Y7S4",
                "type": "external"
            }
        ],
        "mass": 55354.0,
        "length": 478,
        "protein_name": "PRAME family member 26",
        "gene_name": "PRAMEF26",
        "organism": "Human",
        "refseq_name": "PRAME family member 26",
        "refseq_ac": [
            {
                "id": "NP_001293001",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293001",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAMEF26",
        "gene_names_refseq": "PRAMEF26",
        "protein_names_uniprotkb": "PRAME family member 26",
        "protein_names_refseq": "PRAME family member 25; PRAME family member 26; putative PRAME family member 26",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441873);  (hsa:645359)",
        "pathway_count": 2,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "H0Y7S4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "H3BUK9-1",
        "uniprot_id": [
            {
                "id": "POTB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/H3BUK9",
                "type": "external"
            }
        ],
        "mass": 61708.0,
        "length": 544,
        "protein_name": "POTE ankyrin domain family member B2",
        "gene_name": "POTEB2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "POTEB2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "POTE ankyrin domain family member B2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100287399);  (hsa:100996331)",
        "pathway_count": 2,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "H3BUK9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULL1-1",
        "uniprot_id": [
            {
                "id": "PKHG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULL1",
                "type": "external"
            }
        ],
        "mass": 155439.0,
        "length": 1385,
        "protein_name": "Pleckstrin homology domain-containing family G member 1",
        "gene_name": "PLEKHG1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family G member 1 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001025055",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025055",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLEKHG1; KIAA1209",
        "gene_names_refseq": "ARHGEF41; PLEKHG1",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 1",
        "protein_names_refseq": "pleckstrin homology domain containing, family G (with RhoGef domain) member 1; pleckstrin homology domain-containing family G member 1 isoform c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57480);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 3,
        "publication_count": 292,
        "publication_id_list": "10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;10958683;11007481;11058585;11085924;11149925;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12172552;12195014;12221096;12351724;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15579468;15601624;15611138;15728722;15850391;15858067;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16777452;16777849;16862148;16896804;16914516;16968698;17064668;17077126;17081983;17145773;17196961;17214551;17244649;17525332;17583407;17599059;17702745;17765681;17804252;17932950;17976533;18006505;18045877;18056264;18077418;18218625;18249095;18347018;18363964;18396277;18426980;18491316;18653540;18669648;18786931;18835169;18838382;18929667;19269969;19494238;19605563;19673492;19713215;19934221;20400958;20460433;20641033;20679435;20810653;21148482;21454492;21542010;21565175;21613211;21685891;21730051;21865595;21989057;22004470;22096251;22298643;22407364;22461490;22475431;22571869;22608513;22734669;22970203;23200924;23209303;23255595;23288169;23406282;23434736;23572525;23707487;23718289;23940355;24086303;24259668;24335996;24352656;24584464;24859002;24933155;24960694;24996924;25024229;25211221;25428919;25704760;25721503;25795300;25862245;25963737;26129894;26299518;26529257;26598554;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;28028151;28114311;28196833;28825699;28860633;29089502;29358323;29382922;29557506;29967039;30061681;30379171;30429286;30659137;30853411;31844290;31871319;32157095;32203420;32502341;32938616;32983136;33091337;33141586;33936100;33981976;34087483;34171305;34211107;34932366;35051231;35494241;35580925;36241641;36284347;37938771;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9113980;9268338;9305890;9405671;9438849;9490638;9497316;9582072;9659915;9670022;9792683;9822598;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "Acts as a guanine nucleotide exchange factor (GEF) for RAC1 and CDC42., [UniProtKB, PubMed]; Genetic variation in PLEKHG1 is associated with white matter hyperintensities and ischemic stroke, most strongly with the small vessel subtype, suggesting it acts by promoting small vessel arteriopathy. Erratum:[Neurology. 2019 Sep 24;93(13):608. doi: 10.1212/WNL.0000000000007914. PMID: 31551276], [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PLEKHG1 rs9478812 variant substantially increases risk of preeclampsia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T1F2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 29.5,
        "record_id": "Q9ULL1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95744-1",
        "uniprot_id": [
            {
                "id": "PM2P2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95744",
                "type": "external"
            }
        ],
        "mass": 32669.0,
        "length": 297,
        "protein_name": "Putative postmeiotic segregation increased 2-like protein 2",
        "gene_name": "PMS2P2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PMS2P2; PMS2L14; PMS2L2; PMS4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative postmeiotic segregation increased 2-like protein 2; Postmeiotic segregation increased 2-like protein 14; Postmeiotic segregation increased protein 4; Putative postmeiotic segregation increased 2 pseudogene 2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "10101297;25576301;27862975;31530632;31844290;32561536;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016887 ATP hydrolysis activity;GO:0140664 ATP-dependent DNA damage sensor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0032300 mismatch repair complex",
        "go_biological_process": "GO:0006298 mismatch repair",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "O95744-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O96001-1",
        "uniprot_id": [
            {
                "id": "PPR17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O96001",
                "type": "external"
            }
        ],
        "mass": 17866.0,
        "length": 155,
        "protein_name": "Protein phosphatase 1 regulatory subunit 17",
        "gene_name": "PPP1R17",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 17 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001138595",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138595",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP1R17; C7orf16; GSBS",
        "gene_names_refseq": "C7orf16; GSBS; PPP1R17",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 17; G-substrate",
        "protein_names_refseq": "G-substrate; protein phosphatase 1 regulatory subunit 17 isoform 2",
        "tax_id": 9606,
        "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810)",
        "pathway": " (hsa:10842)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "10051666;12955585;22340725;33968037;9920894",
        "class_list": "",
        "function": "G-substrate plays a role in the NO-sGC-cGMP-PKG pathway, cerebellum-dependent long-term memory, & neuroprotection of the ventral tegmentum and retina. Review. Review article, [RefSeq, PubMed]; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes., [UniProtKB]; Single nucleotide polymorphism in the GSBS gene is associated with hypercholesterolemia GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DE58;Q9UDQ0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007417 central nervous system development;GO:0010921 regulation of phosphatase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "O96001-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20264-1",
        "uniprot_id": [
            {
                "id": "PO3F3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20264",
                "type": "external"
            }
        ],
        "mass": 50327.0,
        "length": 500,
        "protein_name": "POU domain, class 3, transcription factor 3",
        "gene_name": "POU3F3",
        "organism": "Human",
        "refseq_name": "POU domain, class 3, transcription factor 3",
        "refseq_ac": [
            {
                "id": "NP_006227",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006227",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POU3F3; BRN1; OTF8",
        "gene_names_refseq": "BRN1; OTF8; POU3F3; SNIBFIS; brain-1; oct-8",
        "protein_names_uniprotkb": "POU domain, class 3, transcription factor 3; Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1; OTF-8; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8",
        "protein_names_refseq": "POU domain, class 3, transcription factor 3; brain-specific homeobox/POU domain protein 1; octamer-binding protein 8; octamer-binding transcription factor 8",
        "tax_id": 9606,
        "disease": "snijders blok-fisher syndrome (MONDO:MONDO:0032830)",
        "pathway": " (hsa:5455);  (R-HSA-9831926)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "2739723;30843771;31217245;31303265;31844290;32236821;33633747;33645921;34357683;35051231;37165752;8703082",
        "class_list": "",
        "function": "Coexistence of severe developmental delay, epilepsy, and hemangioma in Snijders Blok-Fisher syndrome suggests the presence of a POU3F3-related SNIBFIS endophenotype: A case report., [RefSeq, PubMed]; De Novo Variants Disturbing the Transactivation Capacity of POU3F3 Cause Neurodevelopmental Disorders., [RefSeq, PubMed]; Long Noncoding RNA POU3F3 and alpha-Synuclein in Plasma L1CAM Exosomes Combined with beta-Glucocerebrosidase Activity: Potential Predictors of Parkinson's Disease., [RefSeq, PubMed]; POU3F3-related disorder: Defining the phenotype and expanding the molecular spectrum., [RefSeq, PubMed]; The present study showed that lncRNA POU3F3 may promote proliferation and inhibit apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9., [RefSeq, PubMed]; This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]., [RefSeq]; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development (PubMed:31303265). Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P78379;Q4ZG25",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0072218 metanephric ascending thin limb development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P20264-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P58294-1",
        "uniprot_id": [
            {
                "id": "PROK1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P58294",
                "type": "external"
            }
        ],
        "mass": 11715.0,
        "length": 105,
        "protein_name": "Prokineticin-1",
        "gene_name": "PROK1",
        "organism": "Human",
        "refseq_name": "prokineticin-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_115790",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115790",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROK1; PRO1186",
        "gene_names_refseq": "EGVEGF; PK1; PRK1; PROK1",
        "protein_names_uniprotkb": "Prokineticin-1; EG-VEGF; Endocrine-gland-derived vascular endothelial growth factor; Mambakine",
        "protein_names_refseq": "EG-VEGF; black mamba toxin-related protein; endocrine-gland-derived vascular endothelial growth factor; mambakine; prokineticin-1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84432);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 130,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11259612;11322507;11385580;11457843;11528470;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12604792;12719537;1280419;12956774;12975309;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15292351;15340161;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1710450;1710578;1719979;1722333;17289879;18127230;18339712;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23690594;24906252;2649896;27496565;2841328;3086311;31991505;3202875;32876972;3366244;34657605;3525564;37801889;37963927;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis, [RefSeq, PubMed]; Dihydrotestosterone potentiates insulin to up-regulate prokineticin-1 in decidualizing human endometrial stromal cells., [RefSeq, PubMed]; EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications. Publication Status: Online-Only, [RefSeq, PubMed]; Impaired decidualization and relative increase of PROK1 expression in the decidua of patients with unexplained recurrent pregnancy loss showing insulin resistance., [RefSeq, PubMed]; Ovarian cancer derived PKR1 positive exosomes promote angiogenesis by promoting migration and tube formation in vitro., [RefSeq, PubMed]; Plasma Prokineticin 1, a prognostic biomarker in colorectal cancer patients with curative resection: a retrospective cohort study. Publication Status: Online-Only, [RefSeq, PubMed]; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VWD4;Q8TC69",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0051781 positive regulation of cell division;GO:0001935 endothelial cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.1,
        "record_id": "P58294-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q03052-1",
        "uniprot_id": [
            {
                "id": "PO3F1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q03052",
                "type": "external"
            }
        ],
        "mass": 45496.0,
        "length": 451,
        "protein_name": "POU domain, class 3, transcription factor 1",
        "gene_name": "POU3F1",
        "organism": "Human",
        "refseq_name": "POU domain, class 3, transcription factor 1",
        "refseq_ac": [
            {
                "id": "NP_002690",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002690",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POU3F1; OCT6; OTF6",
        "gene_names_refseq": "OCT6; OTF6; POU3F1; SCIP",
        "protein_names_uniprotkb": "POU domain, class 3, transcription factor 1; OTF-6; Oct-6; Octamer-binding protein 6; Octamer-binding transcription factor 6; POU domain transcription factor SCIP",
        "protein_names_refseq": "OTF-6; POU domain transcription factor SCIP; POU domain, class 3, transcription factor 1; octamer-binding protein 6; octamer-binding transcription factor 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5453);  (R-HSA-9619665);  (R-HSA-9823739);  (R-HSA-9832991)",
        "pathway_count": 4,
        "publication_count": 105,
        "publication_id_list": "10203854;10220111;10400691;10727776;10757804;10856243;11115854;11133365;11157804;11356866;11394999;11430795;11430802;11734543;11782409;12056842;12145339;12198163;12782656;12799134;14512514;14522948;14664827;15150276;15189448;15356632;15610069;15695336;15836632;15907797;16136673;16311519;16319321;16373334;16923174;1704008;17325040;17699610;17959798;18634568;18803322;19143832;19156870;19321787;19745155;1975954;19922439;20074535;20149798;20213556;20625412;20832498;21044070;21326363;21411665;21423190;21423191;21448695;21613327;21653862;22053691;22180461;22333914;22492709;22764250;22814607;23695165;23747866;23874858;24191038;24227709;24646194;24671357;24675079;25974668;26423937;26441514;27052315;27220739;27288457;27859941;28832583;28852375;29242379;29748249;33633747;34171305;35051231;37217939;7909356;7925941;7935840;8138712;8349731;8451175;8619637;8627307;8647822;8662541;8842374;9418958;9482253;9705348;9748295;9858769",
        "class_list": "",
        "function": "Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer, [RefSeq, PubMed]; CpG island hypermethylation contributes to down-regulation of Oct-6 mRNA expression in hepatocellular carcinoma., [RefSeq, PubMed]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TAG2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0007420 brain development;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q03052-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VTA0-1",
        "uniprot_id": [
            {
                "id": "PRA17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VTA0",
                "type": "external"
            }
        ],
        "mass": 54769.0,
        "length": 474,
        "protein_name": "PRAME family member 17",
        "gene_name": "PRAMEF17",
        "organism": "Human",
        "refseq_name": "PRAME family member 17",
        "refseq_ac": [
            {
                "id": "NP_001093321",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093321",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAMEF17",
        "gene_names_refseq": "PRAMEF17",
        "protein_names_uniprotkb": "PRAME family member 17",
        "protein_names_refseq": "PRAME family member 17",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:391004)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "29557506;35051231;36010968",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUU4",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q5VTA0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q68D20-1",
        "uniprot_id": [
            {
                "id": "PMS2L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q68D20",
                "type": "external"
            }
        ],
        "mass": 20909.0,
        "length": 193,
        "protein_name": "Protein PMS2CL",
        "gene_name": "PMS2CL",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PMS2CL; PMS2P13",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein PMS2CL; PMS2-C terminal-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "15077197;15256438",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DK88;Q764P1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q68D20-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6DJT9-1",
        "uniprot_id": [
            {
                "id": "PLAG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6DJT9",
                "type": "external"
            }
        ],
        "mass": 55909.0,
        "length": 500,
        "protein_name": "Zinc finger protein PLAG1",
        "gene_name": "PLAG1",
        "organism": "Human",
        "refseq_name": "zinc finger protein PLAG1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001108106",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108106",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAG1",
        "gene_names_refseq": "PLAG1; PSA; SGPA; SRS4; ZNF912",
        "protein_names_uniprotkb": "Zinc finger protein PLAG1; Pleiomorphic adenoma gene 1 protein",
        "protein_names_refseq": "COL1A2/PLAG1 fusion; HAS2/PLAG1 fusion; pleiomorphic adenoma gene 1; zinc finger protein PLAG1 isoform a; zinc finger protein PLAG1",
        "tax_id": 9606,
        "disease": "Silver-Russell syndrome (Disease Ontology:DOID:14681); pleomorphic adenoma (Disease Ontology:DOID:452); silver-russell syndrome 4 (MONDO:MONDO:0030118)",
        "pathway": " (hsa:5324)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10029085;10646861;10987300;11882654;11888928;14695992;14712223;15208321;15642402;16207715;16736500;27920218;28514659;28796236;28832583;29242379;29393594;29632046;31217245;31844290;32157095;32387766;32938616;33968037;34906590;35494241;35580925;35639948;38084640;38266920;38745179;9020842;9525740;9722527",
        "class_list": "",
        "function": "PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal., [RefSeq, PubMed]; PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Pleomorphic adenoma with extensive squamous and mucinous metaplasia and a novel MALAT1::PLAG1 fusion gene., [RefSeq, PubMed]; Pleomorphic adenoma: detection of PLAG1 rearrangement-positive tumor components using whole-slide fluorescence in situ hybridization., [RefSeq, PubMed]; SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors., [RefSeq, PubMed]; Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLC2;Q59GH8;Q9Y4L2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q6DJT9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZSY5-1",
        "uniprot_id": [
            {
                "id": "PPR3F_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZSY5",
                "type": "external"
            }
        ],
        "mass": 82798.0,
        "length": 799,
        "protein_name": "Protein phosphatase 1 regulatory subunit 3F",
        "gene_name": "PPP1R3F",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 3F isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001171674",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171674",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPP1R3F",
        "gene_names_refseq": "HB2E; LL0XNC01-7P3.1; PPP1R3F; R3F",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3F; R3F",
        "protein_names_refseq": "protein phosphatase 1 regulatory subunit 3F isoform 2; protein phosphatase 1, regulatory (inhibitor) subunit 3F",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:89801)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;20398921;20479760;21668450;23092983;23186163;25645385;25880248;28228285;28657654;28904123;29242379;29493099;29557506;30429286;31844290;32357974;32387766;33592498;33968037;34145793;34171305;35051231;36010968;37531237;8938429",
        "class_list": "glycogene",
        "function": "Glycogen-targeting subunit for protein phosphatase 1 (PP1)., [UniProtKB, PubMed]; Hemizygous variants in protein phosphatase 1 regulatory subunit 3F (PPP1R3F) are associated with a neurodevelopmental disorder characterized by developmental delay, intellectual disability and autistic features., [RefSeq, PubMed]; Maps this gene as HB2E at the DXS9823E marker sequence., [RefSeq, PubMed]; Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 941,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2VDJ8;B3KPW2;E9PCM3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding;GO:2001069 glycogen binding",
        "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0016020 membrane",
        "go_biological_process": "GO:0005979 regulation of glycogen biosynthetic process;GO:2000465 regulation of glycogen (starch) synthase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q6ZSY5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q70Z35-1",
        "uniprot_id": [
            {
                "id": "PREX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q70Z35",
                "type": "external"
            }
        ],
        "mass": 182622.0,
        "length": 1606,
        "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein",
        "gene_name": "PREX2",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a",
        "refseq_ac": [
            {
                "id": "NP_079146",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079146",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PREX2; DEPDC2",
        "gene_names_refseq": "DEP.2; DEPDC2; P-REX2; PPP1R129; PREX2",
        "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; DEP domain-containing protein 2; P-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2",
        "protein_names_refseq": "DEP domain-containing protein 2; PtdIns(3,4,5)-dependent Rac exchanger 2; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; protein phosphatase 1, regulatory subunit 129",
        "tax_id": 9606,
        "disease": "hepatitis B (Disease Ontology:DOID:2043); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); Klatskin's tumor (Disease Ontology:DOID:4927); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:80243);  (R-HSA-8948751);  (R-HSA-8980692);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 5,
        "publication_count": 350,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10619026;10699171;10699464;10724160;10873388;10873802;10958683;11007481;11035045;11058585;11085924;11149925;11207612;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12172552;12195014;12221077;12221096;12297295;12351724;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15304342;15304343;15339924;15342493;15485661;15507211;15579468;15601624;15611138;15728722;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16467373;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16959974;16968698;17064668;17077126;17145773;17196961;17214551;17218260;17244649;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18218625;18249095;18347018;18363964;18396277;18426980;18653540;18786931;18829452;18835169;18838382;18929667;19269969;19345329;19473982;19494238;19605563;19635168;19673492;19713215;19729658;19934221;20030946;20101212;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21148482;21351730;21454492;21532586;21542010;21565175;21613211;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22427670;22461490;22475431;22571869;22608513;22673745;22734669;22911862;22970203;22992742;23200924;23209303;23255595;23288169;23406282;23419514;23434736;23481700;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24259668;24270891;24335996;24352656;24367090;24584464;24859002;24933155;24960694;24996924;25024229;25211221;25428919;25547115;25576301;25704760;25721503;25795300;25829446;25862245;25963737;26129894;26154972;26183061;26280536;26299518;26371245;26529257;26598554;26791533;26887924;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27862975;27986909;28028151;28112683;28114311;28196833;28584191;28825699;28832583;28834231;28860633;29089502;29146911;29242379;29358323;29382922;29557506;29786170;29789417;30061681;30315122;30429286;30853411;31105010;31492838;31844290;31871319;32157095;32203420;32357974;32387766;32897882;32938616;33123756;33141586;33298915;34322848;34705970;35051231;35580925;36284347;37938771;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9792683;9822598;9822605;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase., [UniProtKB, PubMed, PubMed, PubMed]; P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis, [RefSeq, PubMed]; P-REX2 may serve as a novel link between Rac activation and the PI-3 kinase pathway., [RefSeq, PubMed]; P-Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)-trisphosphate., [RefSeq, PubMed]; PREX2 gene's expression in gastric antral epithelial cells of patients with H. pylori infection., [RefSeq, PubMed]; PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling., [RefSeq, PubMed]; The pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2 has a role in substrate specificity and recognition, [RefSeq, PubMed]; The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 127,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DFX0;Q32KL0;Q32KL1;Q6R7Q3;Q6R7Q4;Q9H805;Q9H961",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030291 protein serine/threonine kinase inhibitor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0032007 negative regulation of TOR signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 35.5,
        "record_id": "Q70Z35-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YN6-1",
        "uniprot_id": [
            {
                "id": "PRGC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YN6",
                "type": "external"
            }
        ],
        "mass": 113222.0,
        "length": 1023,
        "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta",
        "gene_name": "PPARGC1B",
        "organism": "Human",
        "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001166169",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166169",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPARGC1B; PERC; PGC1B; PGC1; PPARGC1",
        "gene_names_refseq": "ERRL1; PERC; PGC-1(beta); PGC1B; PPARGC1B",
        "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PPAR-gamma coactivator 1-beta; PPARGC-1-beta",
        "protein_names_refseq": "PGC-1-related estrogen receptor alpha coactivator; PPAR-gamma coactivator 1-beta; PPARAGCIbeta; PPARGC-1-beta; PPARgamma coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2; peroxisome proliferator-activated receptor gamma, coactivator 1 beta",
        "tax_id": 9606,
        "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:133522);  (R-HSA-1989781);  (R-HSA-2151201);  (R-HSA-8939902);  (R-HSA-9841922);  (R-HSA-9844594)",
        "pathway_count": 6,
        "publication_count": 131,
        "publication_id_list": "10215629;10412986;10425206;10558993;10572046;10643692;10713165;10777541;10835357;10882139;10911365;11027271;11237011;11267664;11340167;11809803;11854298;12000792;12118000;12177166;12374852;12505311;12563009;12582161;12678921;12738770;12745923;12829629;12832613;12923053;1310260;15067378;15130092;15546003;15635043;15684387;15703179;15863669;16079181;16079853;16115867;16132959;16380219;16421188;16704985;16728642;16788062;16890199;16908542;16911507;16972786;17031457;17437997;17554339;17715127;17761950;17786208;17923681;18215119;18343819;18540824;18541707;18669648;18680753;18719978;18848529;19001277;19043829;19088433;19172745;19356719;19417006;19710929;19934321;19951946;20110263;21931630;22422618;23186163;23300015;23403054;23836911;23943595;24196956;25260729;25880248;26091038;26778333;27557380;28218747;28855257;28904123;29242379;29393594;29437277;29557506;30315122;30379171;31844290;32488085;32502341;33141586;33298915;33329381;33691108;33717175;34087483;34171305;34932366;35051231;36241641;36734290;37460671;37802020;38190589;7629110;7685352;7799916;7892212;8108407;8333869;8521497;8521498;8647822;9012850;9065481;9171241;9178750;9286700;9744270;9748239",
        "class_list": "",
        "function": "HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients., [RefSeq, PubMed]; Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function., [RefSeq, PubMed]; LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1beta upregulation., [RefSeq, PubMed]; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Pulling rank with RNA: RANKL promotes the association of PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts., [RefSeq, PubMed]; The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUM8;A2RUN0;B3KVW0;Q86YN3;Q86YN4;Q86YN5;Q8N1N9;Q8TDE4;Q8TDE5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0030331 nuclear estrogen receptor binding;GO:0050682 AF-2 domain binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0030520 estrogen receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q86YN6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UIW2-1",
        "uniprot_id": [
            {
                "id": "PLXA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UIW2",
                "type": "external"
            }
        ],
        "mass": 211067.0,
        "length": 1896,
        "protein_name": "Plexin-A1",
        "gene_name": "PLXNA1",
        "organism": "Human",
        "refseq_name": "plexin-A1 precursor",
        "refseq_ac": [
            {
                "id": "NP_115618",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115618",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXNA1; NOV; PLXN1",
        "gene_names_refseq": "DWOPNED; NOVP; NOV; PLEXIN-A1; PLXN1; PLXNA1",
        "protein_names_uniprotkb": "Plexin-A1; Semaphorin receptor NOV",
        "protein_names_refseq": "plexin 1; plexin-A1 precursor; semaphorin receptor NOV",
        "tax_id": 9606,
        "disease": "Dworschak-Punetha neurodevelopmental syndrome (MONDO:MONDO:0859260)",
        "pathway": " (hsa:5361);  (R-HSA-399954);  (R-HSA-399955);  (R-HSA-399956);  (R-HSA-416700);  (R-HSA-9013405);  (R-HSA-9696273)",
        "pathway_count": 7,
        "publication_count": 118,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10075701;10520995;10559936;10648410;10664463;10679438;10934324;11114375;11237011;11276226;11278486;11604131;11784792;11940653;12093729;12372285;12422220;12577064;12842009;12882840;14685275;15218527;15550623;15652488;15676027;15738000;16286926;16715077;16930978;17064668;17318185;17607942;17607944;17916560;18996843;19103606;19349973;20811643;22665057;23087206;23090970;23096567;23584533;24102721;24190977;24690281;25576301;25746724;25813380;25892735;26992070;27481945;27600516;27726376;27852748;28486133;28832583;28871256;28904123;28947137;29242379;29314611;29393594;29557506;29769354;29776664;30429286;30573663;31020640;31217245;31611695;31844290;31848261;31871319;32157095;32350084;32387766;32488085;32938616;32983136;33043033;33298915;33392160;33592498;33717175;33912179;33968037;33981976;34019948;34054129;34171305;34185709;34357683;34509645;34561969;35051231;35154160;35251023;35318648;35580925;35852441;36010968;36215666;36241641;36284347;37074911;37938771;38081609;38331165;38508474;39226661;8570614;8945468;8955171;9531558",
        "class_list": "",
        "function": "Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway., [RefSeq, PubMed]; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis., [UniProtKB, UniProtKB]; PLXNA1 confers enzalutamide resistance in prostate cancer via AKT signaling pathway., [RefSeq, PubMed]; PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner., [RefSeq, PubMed]; Rare variant screening and burden analysis of PLXNA1 in Parkinson's disease., [RefSeq, PubMed]; [PLXNA1 is highly expressed in hepatocellular carcinoma and affects patients' survival and immune microenvironment]., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 81,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 9,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017154 semaphorin receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0097485 neuron projection guidance;GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q9UIW2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96KF2-1",
        "uniprot_id": [
            {
                "id": "PRAC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96KF2",
                "type": "external"
            }
        ],
        "mass": 5959.0,
        "length": 57,
        "protein_name": "Small nuclear protein PRAC1",
        "gene_name": "PRAC1",
        "organism": "Human",
        "refseq_name": "small nuclear protein PRAC1",
        "refseq_ac": [
            {
                "id": "NP_115767",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115767",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAC1; C17orf92; PRAC",
        "gene_names_refseq": "C17orf92; PRAC1; PRAC",
        "protein_names_uniprotkb": "Small nuclear protein PRAC1; Prostate cancer susceptibility candidate protein 1; Prostate, rectum and colon expressed gene protein",
        "protein_names_refseq": "prostate cancer susceptibility candidate 1; prostate cancer susceptibility candidate protein 1; prostate, rectum and colon expressed gene protein; small nuclear protein PRAC1; small nuclear protein PRAC",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84366)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11340635;24100630;26074659;30379171;33076847",
        "class_list": "",
        "function": "Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods. Publication Status: Online-Only, [RefSeq, PubMed]; Enhanced methylation of PRAC was positively associated with a high rate of recurrence and progression in nonmuscle invasive bladder cancer patients., [RefSeq, PubMed]; The pathogenesis of prostate cancer may be due to the expression levels of PRAC protein, and this protein can serve as a potential biomarker for the management of prostate cancer., [RefSeq, PubMed]; This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q96KF2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99811-1",
        "uniprot_id": [
            {
                "id": "PRRX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99811",
                "type": "external"
            }
        ],
        "mass": 27079.0,
        "length": 253,
        "protein_name": "Paired mesoderm homeobox protein 2",
        "gene_name": "PRRX2",
        "organism": "Human",
        "refseq_name": "paired mesoderm homeobox protein 2",
        "refseq_ac": [
            {
                "id": "NP_057391",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057391",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRRX2; PMX2; PRX2",
        "gene_names_refseq": "PMX2; PRRX2; PRX2",
        "protein_names_uniprotkb": "Paired mesoderm homeobox protein 2; PRX-2; Paired-related homeobox protein 2",
        "protein_names_refseq": "PRX-2; paired mesoderm homeobox protein 2; paired-like homeodomain protein PRX2; paired-related homeobox protein 2; testicular tissue protein Li 148; testicular tissue protein Li 160",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51450)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11063257;11893718;25576301;29632046;29786170;31255287;31471104;31844290;32234171;34561969;35051231;36266731;9665387",
        "class_list": "",
        "function": "Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons., [RefSeq, PubMed]; CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. Erratum:[J Exp Clin Cancer Res. 2022 Nov 10;41(1):320. doi: 10.1186/s13046-022-02527-7. PMID: 36352462] Publication Status: Online-Only, [RefSeq, PubMed]; Encodes homeobox transcription factors that are expressed during vasculogenesis., [RefSeq, PubMed]; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development., [UniProtKB, PubMed]; PRRX2 inhibition may reduce invasive and migrating abilities to hinder epithelial-mesenchymal transition (EMT), and suppress colon cancer liver metastasis through inactivation of Wnt/beta-catenin pathway., [RefSeq, PubMed]; Silencing Prrx2 expression can effectively inhibit the proliferation and growth of breast cancer, [RefSeq, PubMed]; The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SZB5;Q9UIB3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q99811-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NNZ6-1",
        "uniprot_id": [
            {
                "id": "PRM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NNZ6",
                "type": "external"
            }
        ],
        "mass": 11269.0,
        "length": 103,
        "protein_name": "Protamine-3",
        "gene_name": "PRM3",
        "organism": "Human",
        "refseq_name": "protamine-3",
        "refseq_ac": [
            {
                "id": "NP_067070",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067070",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRM3",
        "gene_names_refseq": "PRM3",
        "protein_names_uniprotkb": "Protamine-3; Sperm protamine P3",
        "protein_names_refseq": "gene 4; protamine-3; sperm protamine P3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58531)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "19602509;8720108",
        "class_list": "",
        "function": "Mutations in the protamine locus may be an infrequent cause of male infertility. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000786 nucleosome",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0030261 chromosome condensation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q9NNZ6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQV8-1",
        "uniprot_id": [
            {
                "id": "PRDM8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQV8",
                "type": "external"
            }
        ],
        "mass": 71663.0,
        "length": 689,
        "protein_name": "PR domain zinc finger protein 8",
        "gene_name": "PRDM8",
        "organism": "Human",
        "refseq_name": "PR domain zinc finger protein 8",
        "refseq_ac": [
            {
                "id": "NP_001092873",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092873",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRDM8; PFM5",
        "gene_names_refseq": "EPM10; KMT8D; PFM5; PRDM8",
        "protein_names_uniprotkb": "PR domain zinc finger protein 8; 2.1.1.-; PR domain-containing protein 8",
        "protein_names_refseq": "PR domain 8; PR domain zinc finger protein 8; PR-domain containing protein 8",
        "tax_id": 9606,
        "disease": "progressive myoclonus epilepsy 10 (Disease Ontology:DOID:0111445)",
        "pathway": " (hsa:56978);  (R-HSA-9762293)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "11237011;15699330;16793922;22227038;22961547;24130169;24810778;25576301;25645385;26909595;27278638;29242379;29269046;29296180;29493099;29572888;29642003;31154438;31844290;32463580;32819411;33968037;34087483;34171305;35051231;35494241;37938771",
        "class_list": "",
        "function": "Aberrant hypermethylation is particularly observed in PRDM8 and this may support identification and classification of bone marrow failure syndromes, [RefSeq, PubMed]; Alteration of hydroxymethylation and methylation of PRDM8 correlates with changes in its expression in the peripheral blood of children with DS. Given the proposed function of PRDM8 in cognitive disability in DS, [RefSeq, PubMed]; PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]., [RefSeq]; Through regulating NAP1L1, PRDM8 inhibits PI3K/AKT/mTOR signaling in hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7X2;Q6IQ36",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0046974 histone H3K9 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0014003 oligodendrocyte development;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9NQV8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y255-1",
        "uniprot_id": [
            {
                "id": "PRLD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y255",
                "type": "external"
            }
        ],
        "mass": 25181.0,
        "length": 219,
        "protein_name": "PRELI domain-containing protein 1, mitochondrial",
        "gene_name": "PRELID1",
        "organism": "Human",
        "refseq_name": "PRELI domain-containing protein 1, mitochondrial isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001258757",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258757",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRELID1; CGI-106; PRELI; SBBI12",
        "gene_names_refseq": "CGI-106; PRELID1; PRELI; PX19; SBBI12",
        "protein_names_uniprotkb": "PRELI domain-containing protein 1, mitochondrial; 25 kDa protein of relevant evolutionary and lymphoid interest; Px19-like protein",
        "protein_names_refseq": "25 kDa protein of relevant evolutionary and lymphoid interest; PRELI domain-containing protein 1, mitochondrial isoform 2 precursor; PRELI domain-containing protein 1, mitochondrial; px19-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27166);  (R-HSA-6803204);  (R-HSA-9837999)",
        "pathway_count": 3,
        "publication_count": 141,
        "publication_id_list": "10784606;10807576;10931946;11030628;11237011;11511362;11684014;11923310;11929585;12198491;12402042;12606722;14623864;14640972;14729977;15104674;15126337;15273740;15522782;15607964;15735003;15870080;15944288;16115876;17101804;17297443;17349958;17579211;18617898;18945965;19377469;19841671;20112406;20707881;21364629;22262461;22334068;22666421;22710082;22766503;22869377;23201127;23365256;23481700;23684607;23931759;24315374;24520911;25080938;25418920;25469497;25576301;26071602;26154972;26275693;26375851;26504172;26811146;26923599;26929215;26992070;27496948;27600516;27642048;27846572;27920218;28063628;28228285;28377575;28396416;28411811;28514659;28832583;28834231;28860189;28904123;28912168;29242379;29301859;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29932645;30120231;30315122;30379171;30429286;30484775;30833945;30850607;31092671;31154438;31217245;31327635;31530632;31695197;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33257573;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;34087483;34108621;34171305;34357683;34561969;34704252;34943861;35051231;35251023;35580925;35870450;36010968;36215666;36241641;36284347;36629048;37938771;7623837;7834749",
        "class_list": "",
        "function": "Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs., [UniProtKB, PubMed, PubMed, PubMed]; PRELI interacts with OPA1 to maintain mitochondria structures intact, sustain balanced ion(-)/proton(+) gradients, promote oxidative phosphorylation reactions, regulate pro- and antiapoptotic protein traffic and enable cell responses to induced death., [RefSeq, PubMed]; PRELI is a vital LEA B cell protein with failsafe genetics, [RefSeq, PubMed]; PRELI plays an important role in the suppression of apoptosis in HepG2 cells in response to oxidative stress., [RefSeq, PubMed]; Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins has been reported. Publication Status: Online-Only, [RefSeq, PubMed]; The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis., [RefSeq, PubMed]; This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]., [RefSeq]; This study suggests that the regulation of PRELID1 expression, by alternative polyadenylation and other mechanisms, plays a role in mitochondrial ROS signaling and represents a novel prognostic factor and therapeutic target in cancer, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5F7;D6RD25;Q549N2;Q9UI13;Q9UJS9",
        "ec_number_list": [
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            }
        ],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0051881 regulation of mitochondrial membrane potential;GO:0015914 phospholipid transport;GO:0045580 regulation of T cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "Q9Y255-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11465-1",
        "uniprot_id": [
            {
                "id": "PSG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11465",
                "type": "external"
            }
        ],
        "mass": 37216.0,
        "length": 335,
        "protein_name": "Pregnancy-specific beta-1-glycoprotein 2",
        "gene_name": "PSG2",
        "organism": "Human",
        "refseq_name": "pregnancy-specific beta-1-glycoprotein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_112536",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112536",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSG2; PSBG2",
        "gene_names_refseq": "CEA; PSBG2; PSG1; PSG2",
        "protein_names_uniprotkb": "Pregnancy-specific beta-1-glycoprotein 2; PS-beta-E; PS-beta-G-2; PSBG-2; Pregnancy-specific beta-1 glycoprotein E; Pregnancy-specific glycoprotein 2",
        "protein_names_refseq": "PS-beta-E; PS-beta-G-2; PSBG-2; carcinoembryonic antigen SG8; pregnancy-specific beta-1 glycoprotein E; pregnancy-specific beta-1-glycoprotein 2 precursor; pregnancy-specific beta-1-glycoprotein 7; pregnancy-specific glycoprotein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5670);  (R-HSA-202733)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "10606205;10764623;11207550;11237011;11256994;11564780;11779189;11812992;12070135;12208882;12469115;12782713;14529530;14615387;15000751;15528364;15681301;15721307;15906358;1591491;16258728;16297198;16585556;16691243;16737840;16783819;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;19279206;20071292;21193412;21659548;23945545;24043627;24764293;25048447;2538457;28411811;28904123;3260773;468991;7509040;7521878;8163559;8166770;8314844;9052782;9169774;9242610;9295288;9382878;9693095;9763524",
        "class_list": "",
        "function": "Integrating the dual-signal amplification strategy, a novel 3D origami electrochemical immunodevice for simultaneous detecting carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125), [RefSeq, PubMed]; The authors evaluated the prognostic significance of the CEA and CA-19.9 serum tumor markers in advanced (unresectable) pancreatic cancer Erratum:[J Chemother. 2010 Feb;22(1):72. Kopteridis, P [corrected to Kopterides, P]], [RefSeq, PubMed]; The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]., [RefSeq]; This genetic cancer vaccineis highly immunogenic and can break tolerance to CEA tumor antigen in CEA transgenic mice., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TCD9;Q9UEA4;Q9UQ78",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0016477 cell migration;GO:0007565 female pregnancy;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "P11465-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0G2JMD5-1",
        "uniprot_id": [
            {
                "id": "PRA33_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0G2JMD5",
                "type": "external"
            }
        ],
        "mass": 55092.0,
        "length": 474,
        "protein_name": "PRAME family member 33",
        "gene_name": "PRAMEF33",
        "organism": "Human",
        "refseq_name": "PRAME family member 33",
        "refseq_ac": [
            {
                "id": "NP_001278310",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278310",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAMEF33",
        "gene_names_refseq": "PRAMEF33P; PRAMEF33",
        "protein_names_uniprotkb": "PRAME family member 33",
        "protein_names_refseq": "PRAME family member 10-like; PRAME family member 33, pseudogene; PRAME family member 33",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:645382)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "31844290",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A0G2JMD5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A3QJZ6-1",
        "uniprot_id": [
            {
                "id": "PRA22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A3QJZ6",
                "type": "external"
            }
        ],
        "mass": 55489.0,
        "length": 481,
        "protein_name": "PRAME family member 22",
        "gene_name": "PRAMEF22",
        "organism": "Human",
        "refseq_name": "PRAME family member 22",
        "refseq_ac": [
            {
                "id": "NP_001094101",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094101",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAMEF22",
        "gene_names_refseq": "PRAMEF22; PRAMEF3L",
        "protein_names_uniprotkb": "PRAME family member 22",
        "protein_names_refseq": "PRAME family member 22",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653606)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NMM3",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A3QJZ6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MPX8-1",
        "uniprot_id": [
            {
                "id": "PP2D1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MPX8",
                "type": "external"
            }
        ],
        "mass": 71643.0,
        "length": 630,
        "protein_name": "Protein phosphatase 2C-like domain-containing protein 1",
        "gene_name": "PP2D1",
        "organism": "Human",
        "refseq_name": "protein phosphatase 2C-like domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_001239586",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239586",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PP2D1; C3orf48",
        "gene_names_refseq": "C3orf48; PP2D1",
        "protein_names_uniprotkb": "Protein phosphatase 2C-like domain-containing protein 1",
        "protein_names_refseq": "protein phosphatase 2C-like domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151649)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "23481700;24715725;30379171",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96LI7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction;GO:0043409 negative regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A8MPX8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5TGL8-1",
        "uniprot_id": [
            {
                "id": "PXDC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5TGL8",
                "type": "external"
            }
        ],
        "mass": 26560.0,
        "length": 231,
        "protein_name": "PX domain-containing protein 1",
        "gene_name": "PXDC1",
        "organism": "Human",
        "refseq_name": "PX domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_899229",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899229",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PXDC1; C6orf145",
        "gene_names_refseq": "C6orf145; PXDC1",
        "protein_names_uniprotkb": "PX domain-containing protein 1",
        "protein_names_refseq": "PX domain-containing protein 1; PX domain-containing protein C6orf145",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221749)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;16959974;20112406;25576301;29393594;29557506;30204804;30779550;31844290;32157095;32488085;35051231;36010968;37938771",
        "class_list": "",
        "function": "We used allele specific expression in lymphoblastoid cell lines from 306 Hutterites related in a single pedigree to provide formal evidence for parent of origin effects. Our approach identified two putative novel imprinted genes, PXDC1 and PWAR6, with asymmetrical parent of origin gene expression. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0N3;Q6PGP0;Q86XB7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q5TGL8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "I3L0S3-1",
        "uniprot_id": [
            {
                "id": "PYAS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/I3L0S3",
                "type": "external"
            }
        ],
        "mass": 21949.0,
        "length": 204,
        "protein_name": "Putative uncharacterized protein PYCARD-AS1",
        "gene_name": "PYCARD-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PYCARD-AS1; C16orf98; PYCARDOS",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein PYCARD-AS1; PYCARD antisense RNA 1; PYCARD antisense gene protein 1; PYCARD opposite strand protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "I3L0S3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P28072-1",
        "uniprot_id": [
            {
                "id": "PSB6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P28072",
                "type": "external"
            }
        ],
        "mass": 25358.0,
        "length": 239,
        "protein_name": "Proteasome subunit beta type-6",
        "gene_name": "PSMB6",
        "organism": "Human",
        "refseq_name": "proteasome subunit beta type-6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_002789",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002789",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMB6; LMPY; Y",
        "gene_names_refseq": "DELTA; LMPY; PSMB6",
        "protein_names_uniprotkb": "Proteasome subunit beta type-6; 3.4.25.1; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit Y; Proteasome subunit beta-1; beta-1",
        "protein_names_refseq": "PSY large multifunctional protease Y; beta-1; macropain delta chain; multicatalytic endopeptidase complex delta chain; proteasome (prosome, macropain) subunit, beta type, 6; proteasome catalytic subunit 1; proteasome delta chain; proteasome subunit Y; proteasome subunit beta 6; proteasome subunit beta type-6 isoform 1; proteasome subunit beta-1; proteasome subunit beta1; proteasome subunit delta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5694);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9912633);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 69,
        "publication_count": 1041,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11237011;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12181345;12186903;12194817;12198130;12234927;12297295;12351678;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;12912907;12915405;12917689;12917691;12923053;12963847;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14550573;14564014;14585973;14603323;14611647;14625308;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15244466;15247232;15257295;15282312;15292211;15300262;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592474;15601839;15611333;15613457;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15944226;15983046;15987702;16056267;16061793;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16962933;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18692471;18701449;18711132;18716059;18719096;18720373;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;1888762;18926707;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19208626;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19617556;19622347;19666503;1968359;19684112;19706539;19729658;19734889;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21177870;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22265677;22267219;22279049;22286099;22306028;22306998;22318583;2236053;22391301;22422618;22427670;22440753;22466964;22505454;22508986;22537386;2261476;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22872865;22885700;22897851;22959436;22964642;22982193;23063411;2306472;23069990;23112049;23140627;23144924;23159851;23186163;23201271;23217742;23236459;23256519;23274085;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23486064;23495936;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23661552;23685075;23719536;23725801;23746841;23783831;23824326;23825189;23851460;23867461;23878308;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24298019;24302888;24309468;24366543;24366607;24367090;24493797;24582806;24585635;24636985;24685677;24714562;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25132172;25133187;25152365;25197364;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25505266;25531226;25547115;25576301;25578727;25578875;25584290;25599644;25645385;25654763;2570070;2570460;25733683;25740432;25793262;25880248;25892735;25921531;26091038;26117325;26133119;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26374642;26443277;26460955;26583321;26632597;26758079;26778333;26906416;26942676;26992070;27030794;27137657;27176742;27222660;27249176;27342858;27428775;27452731;27466718;27493187;27565346;27572267;27846572;27862975;27920218;28115426;28132103;28178531;28218747;28263418;28317937;28380357;28442575;28514659;28598414;28832583;28834231;28904123;2898143;29055231;29153394;29233872;29242379;29356040;29393594;29450944;2946959;29493099;29508533;29526543;29557506;29632312;29632711;29717933;29769354;29786170;30118680;30244831;30315122;30334692;30334693;30429286;30610225;30728908;30779550;30833945;31011209;31020640;31154438;31217245;3129195;31530632;31546975;31679946;31844290;31848261;32005965;32157095;32161166;32284348;32293500;32357974;32387766;32488085;32502341;32640524;32672401;32938616;32981041;32983136;33009401;33141586;33298915;33406423;33444648;33537174;33592498;33717175;33791708;33859744;33909987;33912179;33936100;33968037;34087483;34171305;34215617;34229054;34315872;34357683;34509645;3457471;34711951;3472246;34725712;34932366;35051231;35138101;35318648;35385574;35580925;36010968;36198437;36241641;36581221;37676773;37938771;38665916;39894887;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7628694;7639698;7799959;7809113;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8066462;8107774;8140422;8163024;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8610016;8626374;8662591;8662795;8670417;8689684;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9380723;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues., [UniProtKB, PubMed, PubMed, PubMed]; Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96J55",
        "ec_number_list": [
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-",
                "type": "external"
            },
            {
                "id": "2.4.2.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "4.1.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "1.14.11.29",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29",
                "type": "external"
            },
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0045296 cadherin binding;GO:0004298 threonine-type endopeptidase activity",
        "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 104.4,
        "record_id": "P28072-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15355-1",
        "uniprot_id": [
            {
                "id": "PPM1G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15355",
                "type": "external"
            }
        ],
        "mass": 59272.0,
        "length": 546,
        "protein_name": "Protein phosphatase 1G",
        "gene_name": "PPM1G",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1G",
        "refseq_ac": [
            {
                "id": "NP_817092",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_817092",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPM1G; PPM1C",
        "gene_names_refseq": "PP2CGAMMA; PP2CG; PPM1G; PPP2CG",
        "protein_names_uniprotkb": "Protein phosphatase 1G; 3.1.3.16; PP2C-gamma; Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma",
        "protein_names_refseq": "PP2C-gamma; protein phosphatase 1C; protein phosphatase 1G; protein phosphatase magnesium-dependent 1 gamma",
        "tax_id": 9606,
        "disease": "schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:5496)",
        "pathway_count": 1,
        "publication_count": 100,
        "publication_id_list": "17054950;17287340;17525332;18077418;18669648;19608861;20068231;21406692;22424782;22544926;23186163;23301498;23481700;24129315;24714562;24715725;25255805;25505266;25576301;25645385;25807930;25880248;26154972;26375851;26728094;26853435;26992070;27600516;27846572;27862975;28228285;28832583;28834231;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29789417;30315122;30429286;30484775;30524438;30833945;31154438;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;33043033;33141586;33214551;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34405274;34509645;34725712;34932366;35051231;35083852;35132862;35138101;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36349938;37387407;37938771;38665916;39121976;40307207;40914422;9271424;9276438",
        "class_list": "",
        "function": "Functional study of the mouse homolog, [RefSeq, PubMed]; PPM1G promotes autophagy and progression of pancreatic cancer via upregulating HMGB1., [RefSeq, PubMed]; PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6., [RefSeq, PubMed]; Prognostic and immunological potential of PPM1G in lung adenocarcinoma., [RefSeq, PubMed]; The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner., [RefSeq, PubMed]; The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53",
                "type": "external"
            },
            {
                "id": "3.1.3.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006470 protein dephosphorylation;GO:0035970 peptidyl-threonine dephosphorylation;GO:0051726 regulation of cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "O15355-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60813-1",
        "uniprot_id": [
            {
                "id": "PRA11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60813",
                "type": "external"
            }
        ],
        "mass": 55344.0,
        "length": 478,
        "protein_name": "PRAME family member 11",
        "gene_name": "PRAMEF11",
        "organism": "Human",
        "refseq_name": "PRAME family member 11",
        "refseq_ac": [
            {
                "id": "NP_001139816",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139816",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAMEF11",
        "gene_names_refseq": "PRAMEF11",
        "protein_names_uniprotkb": "PRAME family member 11",
        "protein_names_refseq": "PRAME family member 11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440560)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WW85;B7ZMC2",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "O60813-1",
        "record_type": "protein",
        "filter_code": "0000000.1000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13727-1",
        "uniprot_id": [
            {
                "id": "PRG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13727",
                "type": "external"
            }
        ],
        "mass": 25206.0,
        "length": 222,
        "protein_name": "Bone marrow proteoglycan",
        "gene_name": "PRG2",
        "organism": "Human",
        "refseq_name": "bone marrow proteoglycan isoform 2 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001230174",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230174",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRG2; MBP",
        "gene_names_refseq": "BMPG; MBP1; MBP; PRG2; proMBP",
        "protein_names_uniprotkb": "Bone marrow proteoglycan; BMPG; Pregnancy-associated major basic protein; Proteoglycan 2",
        "protein_names_refseq": "bone marrow proteoglycan isoform 2 preproprotein; bone marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natural killer cell activator; proteoglycan 2 preproprotein; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)",
        "tax_id": 9606,
        "disease": "Chagas disease (Disease Ontology:DOID:12140); peritoneum cancer (Disease Ontology:DOID:1725); asthma (Disease Ontology:DOID:2841)",
        "pathway": " (hsa:5553);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10.1038/emboj.2013.79;10491647;10913121;11319227;12421832;14702039;15489334;1565101;16245931;16554811;16959974;18694936;2323577;23584533;23650620;2501794;25326458;25728769;2584934;28035807;28344315;29242379;29557506;29936783;30459171;31595373;3171483;319906;3199069;32337544;32350084;33091337;33392160;33592498;33689807;33982062;3410852;3422083;35051231;35251023;36213313;37074911;37278449;37453717;39894887;7508748;7524900;7526035;7531438;7539791;7685339;8137941;8507662;8692836",
        "class_list": "glycogene",
        "function": "Comparison of pancreatic enzyme abnormalities and protease-activated receptor-2-positive eosinophils in the duodenum of patients with functional dyspepsia-irritable bowel syndrome overlap with functional dyspepsia alone in Asian populations., [RefSeq, PubMed]; Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA., [UniProtKB, PubMed]; Development and application of novel immunoassays for eosinophil granule major basic proteins to evaluate eosinophilia and myeloproliferative disorders., [RefSeq, PubMed]; Low PRG2 expression is associated with drug resistance in Chronic myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of atopic cataract caused by eosinophil granule major basic protein., [RefSeq, PubMed]; PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percretadagger., [RefSeq, PubMed]; The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]., [RefSeq]; This protein contains a peptide that displays strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 5,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 4,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 5,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 317,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 3,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6XMW0;B2R5I1;P81448;Q14227;Q6ICT2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0030246 carbohydrate binding;GO:0030021 extracellular matrix structural constituent conferring compression resistance",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:1904813 ficolin-1-rich granule lumen;GO:0030133 transport vesicle",
        "go_biological_process": "GO:0006955 immune response;GO:0042742 defense response to bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "P13727-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100110000000.110.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20742-1",
        "uniprot_id": [
            {
                "id": "PZP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20742",
                "type": "external"
            }
        ],
        "mass": 163863.0,
        "length": 1482,
        "protein_name": "Pregnancy zone protein",
        "gene_name": "PZP",
        "organism": "Human",
        "refseq_name": "pregnancy zone protein precursor",
        "refseq_ac": [
            {
                "id": "NP_002855",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002855",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PZP; CPAMD6",
        "gene_names_refseq": "CPAMD6; PZP",
        "protein_names_uniprotkb": "Pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6",
        "protein_names_refseq": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; Pregnancy zone protein; pregnancy zone protein precursor; pregnancy-zone protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5858)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "11237011;16335952;1692292;16959974;19159218;1989698;23090970;2415522;2476433;2478422;2692707;28467828;29314611;29557506;29741879;31154438;32157095;32162841;32350084;32938616;33057846;33388716;33471436;33592498;33912179;33936100;33968037;34357683;34561969;35051231;35154160;35251023;35494241;35580925;35843132;37074911;37831546;7678727",
        "class_list": "",
        "function": "Genetic ablation of pregnancy zone protein promotes breast cancer progression by activating TGF-beta/SMAD signaling. Erratum:[Breast Cancer Res Treat. 2023 Jun;199(3):627-629. doi: 10.1007/s10549-023-06939-7. PMID: 37079214], [RefSeq, PubMed]; High-Level Secretion of Pregnancy Zone Protein Is a Novel Biomarker of DNA Damage-Induced Senescence and Promotes Spontaneous Senescence., [RefSeq, PubMed]; Hypermethylation of the PZP gene is associated with hepatocellular carcinoma cell proliferation, invasion and migration., [RefSeq, PubMed]; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase., [UniProtKB]; Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA)., [RefSeq, PubMed]; The Pregnancy Zone Protein (PZP) is significantly downregulated in the placenta of preeclampsia and HELLP syndrome patients., [RefSeq, PubMed]; The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 64,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ND27;Q15273;Q2NKL2;Q7M4N7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "P20742-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P49335-1",
        "uniprot_id": [
            {
                "id": "PO3F4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P49335",
                "type": "external"
            }
        ],
        "mass": 39427.0,
        "length": 361,
        "protein_name": "POU domain, class 3, transcription factor 4",
        "gene_name": "POU3F4",
        "organism": "Human",
        "refseq_name": "POU domain, class 3, transcription factor 4",
        "refseq_ac": [
            {
                "id": "NP_000298",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000298",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POU3F4; BRN4; OTF9",
        "gene_names_refseq": "BRAIN-4; BRN-4; BRN4; DFN3; DFNX2; OCT-9; OTF-9; OTF9; POU3F4",
        "protein_names_uniprotkb": "POU domain, class 3, transcription factor 4; Brain-4; Brain-specific homeobox/POU domain protein 4; Brn-4; OTF-9; Oct-9; Octamer-binding protein 9; Octamer-binding transcription factor 9",
        "protein_names_refseq": "POU domain, class 3, transcription factor 4; brain-specific homeobox/POU domain protein 4; octamer-binding transcription factor 9",
        "tax_id": 9606,
        "disease": "X-linked deafness 2 (Disease Ontology:DOID:0111737)",
        "pathway": " (hsa:5456)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;26992070;33976695;34133399;35367201;37929330;7581392;7839145;9105675;9298820;9778298",
        "class_list": "",
        "function": "Genome sequencing detects a balanced pericentric inversion with breakpoints that impact the DMD and upstream region of POU3F4 genes., [RefSeq, PubMed]; Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families. Publication Status: Online-Only, [RefSeq, PubMed]; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain., [UniProtKB]; REST Inactivation and Coexpression of ASCL1 and POU3F4 Are Necessary for the Complete Transformation of RB1/TP53-Inactivated Lung Adenocarcinoma into Neuroendocrine Carcinoma., [RefSeq, PubMed]; This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]., [RefSeq]; X-linked Malformation Deafness: Neurodevelopmental Symptoms Are Common in Children With IP3 Malformation and Mutation in POU3F4., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC71;Q5H9G9;Q99410",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0007605 sensory perception of sound",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "P49335-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P86481-1",
        "uniprot_id": [
            {
                "id": "PR20B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P86481",
                "type": "external"
            }
        ],
        "mass": 23262.0,
        "length": 221,
        "protein_name": "Proline-rich protein 20B",
        "gene_name": "PRR20B",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PRR20B",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Proline-rich protein 20B",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122183);  (hsa:729233);  (hsa:729240);  (hsa:729246);  (hsa:729250)",
        "pathway_count": 5,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N7V5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P86481-1",
        "record_type": "protein",
        "filter_code": "0000000.0000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q01851-1",
        "uniprot_id": [
            {
                "id": "PO4F1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q01851",
                "type": "external"
            }
        ],
        "mass": 42697.0,
        "length": 419,
        "protein_name": "POU domain, class 4, transcription factor 1",
        "gene_name": "POU4F1",
        "organism": "Human",
        "refseq_name": "POU domain, class 4, transcription factor 1",
        "refseq_ac": [
            {
                "id": "NP_006228",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006228",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POU4F1; BRN3A; RDC1",
        "gene_names_refseq": "ATITHS; BRN3A; Oct-T1; POU4F1; RDC-1; brn-3A",
        "protein_names_uniprotkb": "POU domain, class 4, transcription factor 1; Brain-3A; Brain-specific homeobox/POU domain protein 3A; Brn-3A; Homeobox/POU domain protein RDC-1; Oct-T1",
        "protein_names_refseq": "POU domain, class 4, transcription factor 1; brain-specific homeobox/POU domain protein 3A; homeobox/POU domain protein RDC-1",
        "tax_id": 9606,
        "disease": "ataxia, intention tremor, and hypotonia syndrome, childhood-onset (MONDO:MONDO:0859158)",
        "pathway": " (hsa:5457);  (R-HSA-6804759)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "10329733;11684014;12203124;12494467;12524540;12934100;1357630;14729977;15598651;16382142;17145718;17719541;18275817;18676979;19303885;20075864;22538442;22864287;22975685;24714389;25356872;25576301;28228285;31530632;32988584;33783914;35051231;35055045;38491910;7623109;8234287",
        "class_list": "",
        "function": "Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells., [UniProtKB, UniProtKB]; Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer., [RefSeq, PubMed]; HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma. Publication Status: Online-Only, [RefSeq, PubMed]; Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor., [RefSeq, PubMed]; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Activates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site., [UniProtKB, UniProtKB]; POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway., [RefSeq, PubMed]; This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14986;Q15318;Q5T227",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0051020 GTPase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043005 neuron projection;GO:0000785 chromatin",
        "go_biological_process": "GO:0060384 innervation;GO:0048880 sensory system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q01851-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14691-1",
        "uniprot_id": [
            {
                "id": "PSF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14691",
                "type": "external"
            }
        ],
        "mass": 22988.0,
        "length": 196,
        "protein_name": "DNA replication complex GINS protein PSF1",
        "gene_name": "GINS1",
        "organism": "Human",
        "refseq_name": "DNA replication complex GINS protein PSF1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_066545",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066545",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GINS1; KIAA0186; PSF1",
        "gene_names_refseq": "GINS1; IMD55; PSF1",
        "protein_names_uniprotkb": "DNA replication complex GINS protein PSF1; GINS complex subunit 1",
        "protein_names_refseq": "DNA replication complex GINS protein PSF1 isoform 1; DNA replication complex GINS protein PSF1; GINS complex subunit 1 (Psf1 homolog); partner of sld five-1",
        "tax_id": 9606,
        "disease": "immunodeficiency 55 (Disease Ontology:DOID:0111993)",
        "pathway": " (hsa:9837);  (R-HSA-176974)",
        "pathway_count": 2,
        "publication_count": 82,
        "publication_id_list": "11237011;17127213;17417653;17545466;17557111;17611626;17652513;22645359;24715725;25418920;25892735;26024233;26154972;26929215;26992070;27600516;27846572;27862975;28063628;28218747;28228285;28414293;28510447;28832583;28834231;28855257;28894200;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29632046;29720506;29769354;30315122;30379171;30524438;30779550;30833945;31217245;31222486;31844290;31848261;32157095;32161166;32265295;32387766;32453425;32502341;32897882;32938616;33141586;33298915;33392160;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34405274;34433824;34694004;34700328;34932366;35051231;35318648;35561310;35580925;35585232;36010968;36241641;37824372;38468464;38880324;39210373",
        "class_list": "",
        "function": "Expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1, [RefSeq, PubMed]; GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via beta-catenin signaling in hepatocellular carcinoma., [RefSeq, PubMed]; GINS1 promotes the initiation and progression of bladder cancer by activating the AKT/mTOR/c-Myc signaling pathway., [RefSeq, PubMed]; OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression. Publication Status: Online-Only, [RefSeq, PubMed]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]., [RefSeq]; Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NQE2;Q9NQI7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex",
        "go_biological_process": "GO:0006260 DNA replication;GO:1902983 DNA strand elongation involved in mitotic DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q14691-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15126-1",
        "uniprot_id": [
            {
                "id": "PMVK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15126",
                "type": "external"
            }
        ],
        "mass": 21995.0,
        "length": 192,
        "protein_name": "Phosphomevalonate kinase",
        "gene_name": "PMVK",
        "organism": "Human",
        "refseq_name": "phosphomevalonate kinase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_006547",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006547",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMVK; PMKI",
        "gene_names_refseq": "HUMPMKI; PMKASE; PMKA; PMK; PMVK; POROK1",
        "protein_names_uniprotkb": "Phosphomevalonate kinase; 2.7.4.2; PMKase; hPMK",
        "protein_names_refseq": "phosphomevalonate kinase isoform 1; testis tissue sperm-binding protein Li 95mP",
        "tax_id": 9606,
        "disease": "porokeratosis (Disease Ontology:DOID:3805)",
        "pathway": " (hsa:10654);  (R-HSA-2426168);  (R-HSA-9969896)",
        "pathway_count": 3,
        "publication_count": 94,
        "publication_id_list": "10026212;10191291;10400691;10620343;10666321;10759542;10896663;11160603;11414710;12083769;12177166;12764144;1377680;14729858;14730012;14766201;16464866;16519518;16684881;17449569;17902708;17925399;18327899;18559965;18618710;18654640;18682402;18726356;18937434;1968462;20068231;20138239;20394422;20450493;20719759;20937905;21420384;22634312;25418920;26202976;26992070;27052676;27600516;27920218;28218747;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29557506;30315122;30429286;30484775;31217245;31844290;31848261;31998317;32157095;32983136;33246356;33592498;33717175;33968037;35580925;36284347;36585568;38036565;5918048;7567999;7592729;7732023;7909540;7911016;7913309;8020941;8593458;8619637;8626466;8626488;8647822;8663599;8798690;8806705;8976377;9099716;9380443;9392419;9604010;9634533;9741684;9748295",
        "class_list": "",
        "function": "CELF1 Selectively Regulates Alternative Splicing of DNA Repair Genes Associated With Cataract in Human Lens Cell Line., [RefSeq, PubMed]; CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data indicate that exome sequencing revealed disseminated superficial porokeratosis (DSP)-associated mutations in phosphomevalonate kinase gene (PMVK). Publication Status: Online-Only, [RefSeq, PubMed]; Found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK.  No indication of a peroxisomal localization was obtained., [RefSeq, PubMed]; This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TZW9",
        "ec_number_list": [
            {
                "id": "2.7.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004631 phosphomevalonate kinase activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q15126-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15678-1",
        "uniprot_id": [
            {
                "id": "PTN14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15678",
                "type": "external"
            }
        ],
        "mass": 135261.0,
        "length": 1187,
        "protein_name": "Tyrosine-protein phosphatase non-receptor type 14",
        "gene_name": "PTPN14",
        "organism": "Human",
        "refseq_name": "tyrosine-protein phosphatase non-receptor type 14",
        "refseq_ac": [
            {
                "id": "NP_005392",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005392",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPN14; PEZ; PTPD2",
        "gene_names_refseq": "CATLPH; PEZ; PTP36; PTPD2; PTPN14",
        "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 14; 3.1.3.48; Protein-tyrosine phosphatase pez",
        "protein_names_refseq": "cytoskeletal-associated protein tyrosine phosphatase; protein-tyrosine phosphatase pez; tyrosine-protein phosphatase non-receptor type 14",
        "tax_id": 9606,
        "disease": "lymphedema-posterior choanal atresia syndrome (MONDO:MONDO:0013324)",
        "pathway": " (hsa:5784);  (R-HSA-9008059)",
        "pathway_count": 2,
        "publication_count": 77,
        "publication_id_list": "10934049;11145836;11839743;12096920;12381835;12808048;12809600;15527767;16534812;16959974;17081983;17525332;17893246;18077418;18390730;18691976;19413330;19415658;19664994;19664995;20826270;20935647;21406692;22233626;22525271;22948661;23186163;24481253;24715725;25418920;25576301;25645385;25729923;25892735;26154972;26375851;26992070;27060871;27862975;28092676;29242379;29393594;29493099;29557506;29786170;30429286;30833945;31154438;31844290;31848261;32157095;32161166;32350084;32488085;32897882;32938616;33141586;33537174;33592498;33912179;33968037;34171305;34405274;35051231;35318648;35580925;35830698;36010968;36215666;36241641;36284347;36898991;37014433;37938771;39191789;39248565;7733990",
        "class_list": "",
        "function": "CircPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription. Publication Status: Online-Only, [RefSeq, PubMed]; HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14., [RefSeq, PubMed]; PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta signaling in smooth muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis., [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VSI0",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0003712 transcription coregulator activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0001946 lymphangiogenesis;GO:0006470 protein dephosphorylation;GO:0046825 regulation of protein export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q15678-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16378-1",
        "uniprot_id": [
            {
                "id": "PROL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16378",
                "type": "external"
            }
        ],
        "mass": 15097.0,
        "length": 134,
        "protein_name": "Proline-rich protein 4",
        "gene_name": "PRR4",
        "organism": "Human",
        "refseq_name": "proline-rich protein 4 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001092008",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092008",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRR4; LPRP; PROL4",
        "gene_names_refseq": "LPRP; PROL4; PRR4",
        "protein_names_uniprotkb": "Proline-rich protein 4; Lacrimal proline-rich protein; Nasopharyngeal carcinoma-associated proline-rich protein 4",
        "protein_names_refseq": "lacrimal proline-rich protein; nasopharyngeal carcinoma-associated proline-rich protein 4; proline rich 4 (lacrimal); proline-rich polypeptide 4; proline-rich protein 4 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11272)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "40667337;12665801;23272196;24715725;24782455;25946035;26173177;29557506;30833945;31154438;31611695;32157095;32357974;32983136;35051231;35251023;35580925;7544782",
        "class_list": "",
        "function": "A new PRR4 isoform designated as PRR4-N3 in addition to PRR4 (gi154448886) and pHL E1F1 (gi1050983) was identified in human tear proteome., [RefSeq, PubMed]; High expression of lacrimal proline-rich protein 4 (PRR4) was found in reflex tears., [RefSeq, PubMed]; Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome., [RefSeq, PubMed]; This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 2954,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA69;F5H0D7;Q8NFB3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q16378-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5K4E3-1",
        "uniprot_id": [
            {
                "id": "POLS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5K4E3",
                "type": "external"
            }
        ],
        "mass": 91955.0,
        "length": 855,
        "protein_name": "Polyserase-2",
        "gene_name": "PRSS36",
        "organism": "Human",
        "refseq_name": "polyserase-2 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001245219",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245219",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRSS36",
        "gene_names_refseq": "PRSS36",
        "protein_names_uniprotkb": "Polyserase-2; 3.4.21.-; Polyserine protease 2; Serine protease 36",
        "protein_names_refseq": "polyserase-2 isoform 2 precursor; polyserase-2; polyserine protease-2; protease, serine 36",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146547)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15536082;29557506;32387766;35580925",
        "class_list": "",
        "function": "Analysis of post-translational processing mechanisms of polyserase-2 revealed that this novel polyprotein is a secreted enzyme whose three protease domains remain as an integral part of a single polypeptide chain Erratum:[J Biol Chem. 2018 Jul 27;293(30):11784. doi: 10.1074/jbc.AAC118.004649. PMID: 30054290], [RefSeq, PubMed]; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1., [UniProtKB]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 9577,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2P5;B4DW80;B7ZMK8;E7EX56;Q8NBY4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q5K4E3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5R3F8-1",
        "uniprot_id": [
            {
                "id": "PPR29_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5R3F8",
                "type": "external"
            }
        ],
        "mass": 89687.0,
        "length": 820,
        "protein_name": "Protein phosphatase 1 regulatory subunit 29",
        "gene_name": "ELFN2",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 29 precursor",
        "refseq_ac": [
            {
                "id": "NP_443138",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443138",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELFN2; KIAA1904; LRRC62; PPP1R29",
        "gene_names_refseq": "ELFN2; LRRC62; PPP1R29",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 29; Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2; Leucine-rich repeat and fibronectin type-III domain-containing protein 6; Leucine-rich repeat-containing protein 62",
        "protein_names_refseq": "dJ63G5.3 (putative Leucine rich protein); leucine-rich repeat and fibronectin type-III domain-containing protein 6; leucine-rich repeat-containing protein 62; protein phosphatase 1 regulatory subunit 29 precursor; protein phosphatase 1 regulatory subunit 29",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114794)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1101/2023.09.13.557529;17081983;19389623;19901323;24190977;25576301;31485013;32897882;32938616;35051231;35081534;36241641;37074911",
        "class_list": "",
        "function": "Authors conclude that extracellular transsynaptic scaffolding by ELFN2 in the brain is a cardinal organizational feature of group III mGluRs essential for their signaling properties and brain function., [RefSeq, PubMed]; Identification of Key Prognostic-Related miRNA-mRNA Pairs in the Progression of Endometrial Carcinoma., [RefSeq, PubMed]; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 9718,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96PY3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane",
        "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0045184 establishment of protein localization;GO:0099560 synaptic membrane adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q5R3F8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WUA2-1",
        "uniprot_id": [
            {
                "id": "PPIL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WUA2",
                "type": "external"
            }
        ],
        "mass": 57225.0,
        "length": 492,
        "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 4",
        "gene_name": "PPIL4",
        "organism": "Human",
        "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 4",
        "refseq_ac": [
            {
                "id": "NP_624311",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_624311",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPIL4",
        "gene_names_refseq": "HDCME13P; PPIL4",
        "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase-like 4; 5.2.1.8; Cyclophilin-like protein PPIL4; PPIase; Rotamase PPIL4",
        "protein_names_refseq": "PPIase; cyclophilin-like protein PPIL4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase-like 4; peptidylprolyl isomerase (cyclophilin)-like 4; rotamase PPIL4; serologically defined breast cancer antigen NY-BR-18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85313);  (R-HSA-72163);  (R-HSA-9918481)",
        "pathway_count": 3,
        "publication_count": 143,
        "publication_id_list": "10882114;11014198;11101529;11233976;11237011;11747608;11978968;11991638;12176931;12411573;12414731;12477934;14519844;14625303;14713954;14762106;15084397;16314458;16809785;17081983;17095540;17322306;17332742;17606899;18220336;18322460;18452278;18593880;18669648;19103666;19165350;19536130;19651622;19664995;19690332;20068231;20166139;20423332;20980672;21406692;21536652;2176635;21911577;22110043;22365833;22959432;22961380;23186163;23222130;23236153;23301498;23345524;24196718;24275569;24304693;24448447;24737827;24914973;25555158;25576301;2558966;26092250;26154972;26375851;26385511;26420826;26758079;26969736;26992070;27108190;27377154;27459055;27683217;27846572;28062851;28076346;28502770;28781166;28834231;28904123;29301961;29360106;29361316;29493099;29557506;2963332;29902443;30315277;30429286;30599162;30705154;30728453;30765414;30975767;31154438;31409651;31530632;31844290;31848261;32157095;32161166;32179686;32329775;32357974;32387766;32494006;32938616;32983136;33091337;33123756;33177556;33243851;33298915;33446560;33592498;33633747;33912179;33968037;33981976;34087483;34171305;34185709;34301950;34822310;34887573;35051231;35215846;35385551;35580925;36010968;37217939;3757028;37938771;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain, [RefSeq, PubMed]; PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans., [RefSeq, PubMed]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)., [UniProtKB]; This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD34;Q7Z3Q5",
        "ec_number_list": [
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "2.7.7.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "2.7.7.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19",
                "type": "external"
            },
            {
                "id": "2.7.1.78",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "Q8WUA2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VT98-1",
        "uniprot_id": [
            {
                "id": "PRA20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VT98",
                "type": "external"
            }
        ],
        "mass": 54784.0,
        "length": 475,
        "protein_name": "PRAME family member 20",
        "gene_name": "PRAMEF20",
        "organism": "Human",
        "refseq_name": "PRAME family member 20",
        "refseq_ac": [
            {
                "id": "NP_001093322",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093322",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRAMEF20; PRAMEF21",
        "gene_names_refseq": "PRAMEF20; PRAMEF21",
        "protein_names_uniprotkb": "PRAME family member 20",
        "protein_names_refseq": "PRAME family member 20/21; PRAME family member 20; PRAME family member 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:645425)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "29557506;31844290;33392160",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q5VT98-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NI37-1",
        "uniprot_id": [
            {
                "id": "PPTC7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NI37",
                "type": "external"
            }
        ],
        "mass": 32646.0,
        "length": 304,
        "protein_name": "Protein phosphatase PTC7 homolog",
        "gene_name": "PPTC7",
        "organism": "Human",
        "refseq_name": "protein phosphatase PTC7 homolog",
        "refseq_ac": [
            {
                "id": "NP_644812",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_644812",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPTC7; TAPP2C",
        "gene_names_refseq": "PPTC7; TA-PP2C; TAPP2C",
        "protein_names_uniprotkb": "Protein phosphatase PTC7 homolog; 3.1.3.16; T-cell activation protein phosphatase 2C-like; T-cell activation protein phosphatase 2C; TA-PP2C",
        "protein_names_refseq": "PTC7 protein phosphatase homolog; protein phosphatase PTC7 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:160760)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "15177553;25576301;25880248;26992070;28218747;28904123;29393594;29437277;29557506;29632046;29789417;30267671;30429286;31092671;31217245;31844290;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33392160;33592498;33968037;34087483;34171305;34185709;34357683;34932366;35051231;35580925;36010968;38992176",
        "class_list": "",
        "function": "Microarray evidence for coexpression of TA-PP2C with IL2 in T-cells and other cell types., [RefSeq, PubMed]; PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF[FBXL4]., [RefSeq, PubMed]; Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:30267671). Positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (By similarity). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (By similarity). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38992176)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWC5;Q68DZ7;Q6UY82",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53",
                "type": "external"
            },
            {
                "id": "3.1.3.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0010795 regulation of ubiquinone biosynthetic process;GO:1904775 positive regulation of ubiquinone biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q8NI37-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WY54-2",
        "uniprot_id": [
            {
                "id": "PPM1E_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WY54",
                "type": "external"
            }
        ],
        "mass": 83952.0,
        "length": 755,
        "protein_name": "Protein phosphatase 1E",
        "gene_name": "PPM1E",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1E",
        "refseq_ac": [
            {
                "id": "NP_055721",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055721",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPM1E; CAMKN; KIAA1072; POPX1",
        "gene_names_refseq": "CAMKPN; CaMKP-N; POPX1; PP2CH; PPM1E; caMKN",
        "protein_names_uniprotkb": "Protein phosphatase 1E; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase N; CaMKN; CaMKP-N; CaMKP-nucleus; Partner of PIX 1; Partner of PIX-alpha; Partner of PIXA",
        "protein_names_refseq": "ca(2+)/calmodulin-dependent protein kinase phosphatase N; caMKP-nucleus; nuclear calmodulin-dependent protein kinase phosphatase; partner of PIX 1; partner of PIX-alpha; partner of PIXA; protein phosphatase 1E (PP2C domain containing); protein phosphatase 1E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22843);  (R-HSA-9617324)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "11864573;12807427;15496589;16269004;16344560;16959974;23301498;26992070;27661114;27793001;28423719;28460435;28834231;31844290;32157095;32357974;33392160;33592498;34185709;35051231;35580925;36010968;36662636;39894887",
        "class_list": "",
        "function": "Data show that miR-135b selectively targets the AMPK phosphatase Ppm1e., [RefSeq, PubMed]; MiR-135b-5p expression downregulates Ppm1e to activate AMPK signaling, which inhibits LPS-induced TNFalpha production via suppressing ROS production and NFkappaB activation., [RefSeq, PubMed]; Our results suggest that miR-135b-induced Ppm1e silence induces AMPK activation to inhibit osteoblastoma cell proliferation., [RefSeq, PubMed]; Ppm1E upregulation in human gastric cancer is important for cell proliferation, possible via regulating AMPK-mTOR signaling., [RefSeq, PubMed]; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity)., [UniProtKB, PubMed]; Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes., [RefSeq, PubMed]; The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (POPX1; POPX2), [RefSeq, PubMed]; This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2X1;Q68DW1;Q7LAF3;Q9UPT0",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "3.1.3.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006469 negative regulation of protein kinase activity;GO:0071466 cellular response to xenobiotic stimulus;GO:0071222 cellular response to lipopolysaccharide;GO:0051496 positive regulation of stress fiber assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q8WY54-2",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QR8-1",
        "uniprot_id": [
            {
                "id": "PURB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QR8",
                "type": "external"
            }
        ],
        "mass": 33241.0,
        "length": 312,
        "protein_name": "Transcriptional regulator protein Pur-beta",
        "gene_name": "PURB",
        "organism": "Human",
        "refseq_name": "transcriptional regulator protein Pur-beta",
        "refseq_ac": [
            {
                "id": "NP_150093",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150093",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PURB",
        "gene_names_refseq": "PURBETA; PURB",
        "protein_names_uniprotkb": "Transcriptional regulator protein Pur-beta; Purine-rich element-binding protein B",
        "protein_names_refseq": "transcriptional activator protein Pur-beta; transcriptional regulator protein Pur-beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5814)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11417483;12933792;1448097;17081983;17322306;18212344;18220336;18318008;18452278;18669648;19413330;19415658;19651622;19690332;20068231;20166139;21406692;23186163;23301498;24446247;25576301;26992070;27064749;27846572;27862975;28834231;28834593;29242379;29393594;29557506;29789417;30779550;31020640;31530632;31844290;32488085;32502341;32938616;32983136;33592498;33717175;33912179;33968037;34019948;35132862;35580925;36581221;40307207;40914422",
        "class_list": "",
        "function": "Results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed, [RefSeq, PubMed]; Results showed that Purbeta ssDNA-binding activity was significantly increased in myeloid cells from AML patients suggesting that the enhanced ssDNA-binding activity of Purbeta in transformed myeloid cells may serve as a unique and measurable phenotypic trait for improving prognostic risk stratification in AML., [RefSeq, PubMed]; Site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric..., [RefSeq, PubMed]; Suggest dynamic interplay between transcriptional activators Pur-alpha/Pur-beta and repressors in regulating SMalphaA gene output during myofibroblast differentiation., [RefSeq, PubMed]; This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2L7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045637 regulation of myeloid cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q96QR8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BU68-1",
        "uniprot_id": [
            {
                "id": "PR15L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BU68",
                "type": "external"
            }
        ],
        "mass": 11705.0,
        "length": 103,
        "protein_name": "Proline-rich protein 15-like protein",
        "gene_name": "PRR15L",
        "organism": "Human",
        "refseq_name": "proline-rich protein 15-like protein",
        "refseq_ac": [
            {
                "id": "NP_077296",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077296",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRR15L; ATAD4",
        "gene_names_refseq": "ATAD4; PRR15L",
        "protein_names_uniprotkb": "Proline-rich protein 15-like protein; Protein ATAD4",
        "protein_names_refseq": "ATPase family, AAA domain containing 4; proline-rich protein 15-like protein; testicular tissue protein Li 157",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79170)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "18491316;34185709",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTU0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q9BU68-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H0K6-1",
        "uniprot_id": [
            {
                "id": "PUS7L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H0K6",
                "type": "external"
            }
        ],
        "mass": 80700.0,
        "length": 701,
        "protein_name": "Pseudouridylate synthase PUS7L",
        "gene_name": "PUS7L",
        "organism": "Human",
        "refseq_name": "pseudouridylate synthase PUS7L isoform a",
        "refseq_ac": [
            {
                "id": "NP_001092084",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092084",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PUS7L",
        "gene_names_refseq": "PUS7L",
        "protein_names_uniprotkb": "Pseudouridylate synthase PUS7L; 5.4.99.-; Pseudouridylate synthase 7 homolog-like protein",
        "protein_names_refseq": "pseudouridylate synthase 7 homolog-like protein; pseudouridylate synthase 7 like; pseudouridylate synthase PUS7L isoform a; pseudouridylate synthase PUS7L",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83448)",
        "pathway_count": 1,
        "publication_count": 76,
        "publication_id_list": "11230166;11237011;19913121;20628086;23186163;23481700;24397554;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26992070;27455993;27600516;27846572;27862975;27920218;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30379171;30410026;30429286;30524438;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;35051231;35051350;35561310;35580925;36215666;36241641;39302247",
        "class_list": "",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pseudouridine synthase that catalyzes pseudouridylation of mRNAs., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUJ1;Q05CU0;Q6AHZ3;Q6NUP2",
        "ec_number_list": [
            {
                "id": "5.4.99.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25",
                "type": "external"
            },
            {
                "id": "5.4.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-",
                "type": "external"
            },
            {
                "id": "5.4.99.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.42",
                "type": "external"
            },
            {
                "id": "5.4.99.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.28",
                "type": "external"
            },
            {
                "id": "5.4.99.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0001522 pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis;GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q9H0K6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H939-1",
        "uniprot_id": [
            {
                "id": "PPIP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H939",
                "type": "external"
            }
        ],
        "mass": 38858.0,
        "length": 334,
        "protein_name": "Proline-serine-threonine phosphatase-interacting protein 2",
        "gene_name": "PSTPIP2",
        "organism": "Human",
        "refseq_name": "proline-serine-threonine phosphatase-interacting protein 2",
        "refseq_ac": [
            {
                "id": "NP_077748",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077748",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSTPIP2",
        "gene_names_refseq": "MAYP; PSTPIP2",
        "protein_names_uniprotkb": "Proline-serine-threonine phosphatase-interacting protein 2; PEST phosphatase-interacting protein 2",
        "protein_names_refseq": "PEST phosphatase-interacting protein 2; proline-serine-threonine phosphatase-interacting protein 2",
        "tax_id": 9606,
        "disease": "chronic recurrent multifocal osteomyelitis (Disease Ontology:DOID:0060645)",
        "pathway": " (hsa:9050)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "20032092;23481700;24407241;25576301;26992070;27862975;28832583;29242379;29393594;29493099;29508533;29557506;29789417;29930882;30379171;30429286;31247120;32502341;32897882;32938616;32983136;33311489;33981976;34087483;35051231;35580925;36241641;37695226",
        "class_list": "",
        "function": "Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)., [UniProtKB]; Methylation on PSTPIP2 is associated with the development of anti-tuberculosis drug-induced liver injury., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Publication Status: Online-Only, [RefSeq, PubMed]; PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; PSTPIP2 is associated with disease severity in patients with pressure ulcer sepsis and has anti-inflammatory effects. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q9H939-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQX0-3",
        "uniprot_id": [
            {
                "id": "PRDM6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQX0",
                "type": "external"
            }
        ],
        "mass": 64452.0,
        "length": 595,
        "protein_name": "Putative histone-lysine N-methyltransferase PRDM6",
        "gene_name": "PRDM6",
        "organism": "Human",
        "refseq_name": "putative histone-lysine N-methyltransferase PRDM6",
        "refseq_ac": [
            {
                "id": "NP_001129711",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129711",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRDM6; PFM3",
        "gene_names_refseq": "KMT8C; PDA3; PRDM6; PRISM",
        "protein_names_uniprotkb": "Putative histone-lysine N-methyltransferase PRDM6; 2.1.1.361; PR domain zinc finger protein 6; PR domain-containing protein 6",
        "protein_names_refseq": "PR domain 6; PR domain containing 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; putative histone-lysine N-methyltransferase PRDM6",
        "tax_id": 9606,
        "disease": "patent ductus arteriosus (Disease Ontology:DOID:13832); patent ductus arteriosus 3 (MONDO:MONDO:0024266)",
        "pathway": " (hsa:93166)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1101/2023.09.13.557529;10668202;25035420;26992070;27181681;30429286;30677029;31848261;35051231;35580925;36010968;38071433;38992221",
        "class_list": "",
        "function": "Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Erratum:[Am J Hum Genet. 2016 Oct 6;99(4):1000. doi: 10.1016/j.ajhg.2016.09.003. PMID: 27716515], [RefSeq, PubMed]; PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression. Publication Status: Online-Only, [RefSeq, PubMed]; Patent ductus arteriosus and coarctation of the aorta in association with PRDM6 variants., [RefSeq, PubMed]; Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression., [UniProtKB, UniProtKB]; The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]., [RefSeq]; Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 locus) were associated with QRS duration; and rs17026156 (SLC8A1 locus) correlated with PR interval., [RefSeq, PubMed]; We detected a novel obesity and BMI-associated locus at PKHD1 and novel variants driving associations at previously established signals (e.g. rs205262 at the SNRPC/C6orf106 locus and rs112446794 at the PRDM6-CEP120 locus). Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MCJ4;Q9NQW9",
        "ec_number_list": [
            {
                "id": "2.1.1.362",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362",
                "type": "external"
            },
            {
                "id": "2.1.1.361",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.355",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355",
                "type": "external"
            },
            {
                "id": "2.1.1.354",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0140944 histone H4K20 monomethyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q9NQX0-3",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKA9-1",
        "uniprot_id": [
            {
                "id": "PTBP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKA9",
                "type": "external"
            }
        ],
        "mass": 57491.0,
        "length": 531,
        "protein_name": "Polypyrimidine tract-binding protein 2",
        "gene_name": "PTBP2",
        "organism": "Human",
        "refseq_name": "polypyrimidine tract-binding protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001287914",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287914",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTBP2; NPTB; PTBLP; PTB",
        "gene_names_refseq": "PTBLP; PTBP2; brPTB; nPTB",
        "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 2; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein",
        "protein_names_refseq": "PTB-like protein; neural polypyrimidine tract binding protein; neurally-enriched homolog of PTB; polypyrimidine tract-binding protein 2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58155)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "11003644;11237011;11694331;12213192;12667457;16002244;17548433;19029303;20068231;22898188;23481700;24715725;25645385;25880248;25892735;26154972;26375851;26992070;27600516;28218747;28228285;28832583;28834231;29242379;29331515;29557506;29632711;29671580;29786170;30315122;30524438;30779550;31154438;31217245;31844290;31848261;32157095;32161166;32357974;32387766;32938616;33091337;33141586;33298915;33392160;33592498;33691108;33912179;33968037;33981976;34405274;34509645;35051231;35295960;36010968;36284347;37149717;38597390",
        "class_list": "",
        "function": "Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. Publication Status: Online-Only, [RefSeq, PubMed]; KIS counteracts PTBP2 and regulates alternative exon usage in neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation., [UniProtKB, UniProtKB, PubMed, PubMed]; Reduced affinity for RNA., [UniProtKB, PubMed]; Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c., [RefSeq, PubMed]; The nPTB proximal promoter, although rich in G+C content and presenting putative binding sites for the transcription factors Sp1, NF-1, NF-kB and Oct-1, lacks a typical TATA box., [RefSeq, PubMed]; The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 8818,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N0Z1;Q8N160;Q8NFB0;Q8NFB1;Q969N9;Q96Q76",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0005681 spliceosomal complex",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0021510 spinal cord development;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0021549 cerebellum development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9UKA9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULR3-1",
        "uniprot_id": [
            {
                "id": "PPM1H_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULR3",
                "type": "external"
            }
        ],
        "mass": 56448.0,
        "length": 514,
        "protein_name": "Protein phosphatase 1H",
        "gene_name": "PPM1H",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1H",
        "refseq_ac": [
            {
                "id": "NP_065751",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065751",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPM1H; ARHCL1; KIAA1157; URCC2",
        "gene_names_refseq": "ARHCL1; NERPP-2C; PPM1H; URCC2",
        "protein_names_uniprotkb": "Protein phosphatase 1H; 3.1.3.16",
        "protein_names_refseq": "neurite extension-related protein phosphatase related to PP2C; protein phosphatase 1H (PP2C domain containing); protein phosphatase 1H; ras homolog gene family, member C like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57460)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "18059182;18669648;19139490;19651622;19664995;20068231;20659327;20732627;21406692;22586611;23186163;26992070;27600516;28832583;28834231;29393594;30429286;30833945;31154438;31663853;31844290;32157095;32387766;32488085;33847131;34171305;34561969;35051231;35251023;35318648;35580925;37133994;37889931",
        "class_list": "",
        "function": "Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation., [UniProtKB, PubMed]; Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins Publication Status: Online-Only, [RefSeq, PubMed]; PPM1H is an independent prognostic biomarker of non-small cell lung cancer., [RefSeq, PubMed]; PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein., [RefSeq, PubMed]; Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1Q2A9;B2RXG4;Q6PI86",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53",
                "type": "external"
            },
            {
                "id": "3.1.3.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0042802 identical protein binding;GO:0004721 phosphoprotein phosphatase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9ULR3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y570-1",
        "uniprot_id": [
            {
                "id": "PPME1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y570",
                "type": "external"
            }
        ],
        "mass": 42315.0,
        "length": 386,
        "protein_name": "Protein phosphatase methylesterase 1",
        "gene_name": "PPME1",
        "organism": "Human",
        "refseq_name": "protein phosphatase methylesterase 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001258522",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258522",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPME1; PME1; PP2593; PRO0750",
        "gene_names_refseq": "ABDH19; PME-1; PPME1",
        "protein_names_uniprotkb": "Protein phosphatase methylesterase 1; 3.1.1.89; PME-1",
        "protein_names_refseq": "protein phosphatase methylesterase 1 isoform b; testicular secretory protein Li 39",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51400);  (R-HSA-69273)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10318862;10393926;10395539;10600115;10652300;10827953;11063929;11238451;11313932;11897663;11907280;12411508;12665801;12754270;1384126;15024056;15456846;15498874;15572030;16408927;16582612;1717476;17287340;17533373;17803990;1828290;18285455;1836978;18384749;18394995;18669648;19160488;19192479;19293187;19413330;19690332;20068231;20360007;21398589;21813648;21900495;22645359;23186163;23242214;23301498;24129315;24275569;24841198;25418920;25576301;26024233;26811146;26992070;27600516;27846572;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29154753;29242379;29393594;29437277;29493099;29557506;29632046;29786170;30315122;30379171;30429286;30484775;31217245;31844290;31848261;32071079;32157095;32265295;32351291;32488085;32502341;32938616;33214551;33298915;33402344;33633747;33691108;33717175;33771996;33968037;34019948;34229054;34357683;35051231;35580925;36010968;36215666;36241641;36461911;36581221;38588804;40914422;7737117;7743995;7799941;8119945;8428596;8440392;9268380;9670027;9679058",
        "class_list": "",
        "function": "Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors., [RefSeq, PubMed]; DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p., [RefSeq, PubMed]; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme., [UniProtKB, PubMed]; Observations identify PME-1 expression as one mechanism by which ERK pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas., [RefSeq, PubMed]; PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers., [RefSeq, PubMed]; Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1., [RefSeq, PubMed]; The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction., [RefSeq, PubMed]; This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]., [RefSeq]; We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMU6;B5MEE7;J3QT22;Q8WYG8;Q9NVT5;Q9UI18",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.1.89",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0045296 cadherin binding;GO:0051721 protein phosphatase 2A binding;GO:0019903 protein phosphatase binding;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q9Y570-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NEC2-1",
        "uniprot_id": [
            {
                "id": "PSAL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NEC2",
                "type": "external"
            }
        ],
        "mass": 53747.0,
        "length": 478,
        "protein_name": "Puromycin-sensitive aminopeptidase-like protein",
        "gene_name": "NPEPPSL1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NPEPPSL1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Puromycin-sensitive aminopeptidase-like protein; 3.4.11.-",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 23,
        "publication_id_list": "23481700;25418920;25576301;25645385;25802875;26154972;26992070;27846572;28063628;28860189;28904123;29393594;29632046;31844290;32265295;32350084;32357974;32387766;32561536;33141586;33392160;33981976;34357683",
        "class_list": "",
        "function": "Aminopeptidase with broad substrate specificity to several peptides., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MZ60",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "A6NEC2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MTI9-1",
        "uniprot_id": [
            {
                "id": "PRS47_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MTI9",
                "type": "external"
            }
        ],
        "mass": 41188.0,
        "length": 375,
        "protein_name": "Putative serine protease 47",
        "gene_name": "PRSS47P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PRSS47P; PRSS47",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative serine protease 47; 3.4.21.-; Serine protease 47, pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A8MTI9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B1ATL7-1",
        "uniprot_id": [
            {
                "id": "PRR32_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B1ATL7",
                "type": "external"
            }
        ],
        "mass": 31890.0,
        "length": 298,
        "protein_name": "Proline-rich protein 32",
        "gene_name": "PRR32",
        "organism": "Human",
        "refseq_name": "proline-rich protein 32",
        "refseq_ac": [
            {
                "id": "NP_001116188",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116188",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRR32; CXorf64",
        "gene_names_refseq": "CXorf64; PRR32",
        "protein_names_uniprotkb": "Proline-rich protein 32",
        "protein_names_refseq": "proline-rich protein 32",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100130613)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "B1ATL7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21246-1",
        "uniprot_id": [
            {
                "id": "PTN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21246",
                "type": "external"
            }
        ],
        "mass": 18942.0,
        "length": 168,
        "protein_name": "Pleiotrophin",
        "gene_name": "PTN",
        "organism": "Human",
        "refseq_name": "pleiotrophin isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001308315",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308315",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTN; HBNF1; NEGF1",
        "gene_names_refseq": "HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF-1; HBNF; NEGF1; OSF-1; PTN",
        "protein_names_uniprotkb": "Pleiotrophin; HB-GAM; HBBM; HBGF-8; HBNF-1; HBNF; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neurite outgrowth-promoting factor 1; Heparin-binding neurite outgrowth-promoting factor; OSF-1; Osteoblast-specific factor 1; PTN",
        "protein_names_refseq": "heparin affin regulatory protein; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; heparin-binding neurite outgrowth-promoting factor 1; osteoblast-specific factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); pleiotrophin isoform 1 precursor",
        "tax_id": 9606,
        "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); adrenal carcinoma (Disease Ontology:DOID:3950); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:5764);  (R-HSA-201556);  (R-HSA-9851151)",
        "pathway_count": 3,
        "publication_count": 102,
        "publication_id_list": "10212223;10706604;11110708;11121404;11237011;11278720;11280786;11607835;11751994;11850821;12107166;12122009;12424201;12934099;14563642;1457401;14962911;15226403;15317731;15374880;15588951;15592455;15895073;15938644;16153455;16170336;16317043;16814777;16825495;16871283;16878150;16939498;1701634;17086210;17185414;17274988;1733956;17353907;17681947;1768439;18070884;18097461;18724359;18923524;18990089;19141530;19442624;19459784;20632993;20719933;20873783;21154129;21345110;22162641;22286764;22439933;2270483;23201355;23239810;23777859;2388713;23889739;24060861;24356251;24670165;24736079;24947326;25331893;25342631;25421750;26418745;26464158;26630010;26708155;26896299;27445335;27780853;29380702;29455642;29873274;29964125;30061385;30429286;30667096;30692217;31154438;31585938;31848261;33592498;34646012;34819673;35588441;36828390;37269057;37850119;37960806;8241100;8484754;8484780;8633037;9299545;9819383",
        "class_list": "glycogene",
        "function": "Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA PITPNA-AS1/miR-223-3p/PTN axis regulates malignant progression and stemness in lung squamous cell carcinoma., [RefSeq, PubMed]; Pleiotrophin drives a prometastatic immune niche in breast cancer., [RefSeq, PubMed]; Prognostic evaluation of oral squamous cell carcinoma based on pleiotrophin, urokinase plasminogen activator, and glycoprotein nonmetastatic melanoma protein B expression., [RefSeq, PubMed]; Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:11278720, PubMed:16814777, PubMed:19141530). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (PubMed:26896299, PubMed:27445335). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:11278720, PubMed:1733956, PubMed:1768439, PubMed:19141530, PubMed:19442624, PubMed:27445335, PubMed:30667096). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:10706604, PubMed:16814777, PubMed:17681947, PubMed:27445335, PubMed:30667096). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335, PubMed:30667096). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (PubMed:19141530). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (PubMed:11278720). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury., [RefSeq, PubMed]; The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 221,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5U0B0;Q6ICQ5;Q9UCC6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019901 protein kinase binding;GO:0030246 carbohydrate binding;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0048680 positive regulation of axon regeneration;GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P21246-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E5RG02-1",
        "uniprot_id": [
            {
                "id": "PRS46_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E5RG02",
                "type": "external"
            }
        ],
        "mass": 19341.0,
        "length": 174,
        "protein_name": "Putative serine protease 46",
        "gene_name": "PRSS46P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PRSS46P; PRSS46",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative serine protease 46; 3.4.21.-; Serine protease 46 pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "E5RG02-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E7EW31-1",
        "uniprot_id": [
            {
                "id": "PROB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E7EW31",
                "type": "external"
            }
        ],
        "mass": 106917.0,
        "length": 1015,
        "protein_name": "Proline-rich basic protein 1",
        "gene_name": "PROB1",
        "organism": "Human",
        "refseq_name": "proline-rich basic protein 1",
        "refseq_ac": [
            {
                "id": "NP_001155018",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155018",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PROB1; C5orf65",
        "gene_names_refseq": "C5orf65; PROB1",
        "protein_names_uniprotkb": "Proline-rich basic protein 1",
        "protein_names_refseq": "proline-rich basic protein 1; weakly similar to basic proline-rich protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389333)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "19240791;27703147;27920218;29557506;30429286;31530632;31848261;32897882;32938616;33298915;33912179;33968037;33981976;35051231;36010968;39894887",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E007",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "E7EW31-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00232-1",
        "uniprot_id": [
            {
                "id": "PSD12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00232",
                "type": "external"
            }
        ],
        "mass": 52904.0,
        "length": 456,
        "protein_name": "26S proteasome non-ATPase regulatory subunit 12",
        "gene_name": "PSMD12",
        "organism": "Human",
        "refseq_name": "26S proteasome non-ATPase regulatory subunit 12 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001303270",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303270",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMD12",
        "gene_names_refseq": "PSMD12; Rpn5; STISS; p55",
        "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55",
        "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 12 isoform 3; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); Stankiewicz-Isidor syndrome (MONDO:MONDO:0054591)",
        "pathway": " (hsa:5718);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-6798695);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 69,
        "publication_count": 1037,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11237011;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12186903;12194817;12198130;12234927;12297295;12351678;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12665801;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;12912907;12915405;12917689;12917691;12923053;12963847;1317798;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14564014;14585973;14603323;14611647;14625308;14654843;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15247232;15257295;15282312;15292211;15300262;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592474;15601839;15611333;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15983046;15987702;16056267;16061793;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16962933;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18452278;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18692471;18701449;18711132;18716059;18719096;18720373;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;18926707;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19208626;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19608861;19617556;19622347;19666503;1968359;19684112;19706539;19729658;19734889;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21177870;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22265677;22267219;22279049;22286099;22306028;22306998;22318583;2236053;22391301;22422618;22427670;22440753;22466964;22505454;22508986;22537386;2261476;22645359;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22872865;22885700;22897851;22959436;22964642;22982193;23063411;23069990;23112049;23140627;23144924;23159851;23201271;23217742;23236459;23256519;23274085;23301498;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23486064;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23650620;23661552;23685075;23719536;23725801;23746841;23824326;23825189;23851460;23867461;23878308;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24298019;24302888;24309468;24366543;24366607;24367090;24493797;24582806;24585635;24636985;24685677;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25114211;25132172;25133187;25152365;25197364;25218447;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25418920;25531226;25547115;25576301;25578727;25578875;25584290;25645385;25654763;2570070;2570460;25733683;25740432;25772364;25793262;25810538;25921531;26024233;26030138;26091038;26117325;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26443277;26460955;26583321;26632597;26778333;26811146;26906416;26942676;26992070;27030794;27137657;27222660;27249176;27342858;27428775;27466718;27565346;27572267;27600516;27846572;27862975;28115426;28132103;28132691;28178531;28263418;28317937;28380357;28442575;28510447;28598414;28904123;2898143;29055231;29153394;29233872;29242379;29331515;29356040;29450944;2946959;29493099;29508533;29526543;29557506;29632312;29632711;29717933;29786170;29789417;30118680;30244831;30334692;30334693;30410026;30429286;30484775;30610225;30728908;31011209;3129195;31546975;31679946;31844290;32005965;32157095;32265295;32284348;32293500;32350084;32357974;32387766;32488085;32502341;32640524;32672401;32870666;32897882;32938616;32981041;32983136;33009401;33141586;33298915;33406423;33444648;33592498;33633747;33717175;33791708;33859744;33909987;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34215617;34315872;34357683;34509645;3457471;3472246;34725712;34932366;35008409;35051231;35138101;35154160;35318648;35385574;35561310;35580925;36010968;36137220;36198437;36215666;36241641;37037907;37676773;37938771;38243044;38665916;40914422;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7628694;7639698;7799959;7809113;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8107774;8140422;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8626374;8662591;8662795;8670417;8689684;8692836;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9380723;9426256;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, PubMed]; PSMD12 interacts with CDKN3 and facilitates pancreatic cancer progression., [RefSeq, PubMed]; PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway., [RefSeq, PubMed]; PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer., [RefSeq, PubMed]; The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NP15;Q53HA2;Q6P053",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 104.0,
        "record_id": "O00232-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01270-1",
        "uniprot_id": [
            {
                "id": "PTHY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01270",
                "type": "external"
            }
        ],
        "mass": 12861.0,
        "length": 115,
        "protein_name": "Parathyroid hormone",
        "gene_name": "PTH",
        "organism": "Human",
        "refseq_name": "parathyroid hormone isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000306",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000306",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTH",
        "gene_names_refseq": "FIH1; PTH1; PTH",
        "protein_names_uniprotkb": "Parathyroid hormone; PTH; Parathormone; Parathyrin",
        "protein_names_refseq": "parathormone; parathyrin; parathyroid hormone 1; parathyroid hormone isoform 1 preproprotein; prepro-PTH; preproparathyroid hormone",
        "tax_id": 9606,
        "disease": "hyperphosphatemia (Disease Ontology:DOID:0050459); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); familial isolated hypoparathyroidism 1 (Disease Ontology:DOID:0061150); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); familial isolated hypoparathyroidism (Disease Ontology:DOID:0111387); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hypercalcemia (Disease Ontology:DOID:12678); nephrocalcinosis (Disease Ontology:DOID:12679); renal osteodystrophy (Disease Ontology:DOID:13068); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); atrophic gastritis (Disease Ontology:DOID:8929); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:5741);  (R-HSA-373080);  (R-HSA-418555)",
        "pathway_count": 3,
        "publication_count": 103,
        "publication_id_list": "10097073;10523031;10623601;10837469;11007482;1125201;11297558;11604398;12036966;12058044;12098667;12106601;12180353;12559132;12860470;13549488;1373743;14671004;1517224;15340161;15498814;15765929;15769620;15951850;16313925;16602827;16687412;16923326;17168849;18044684;18056632;18375760;18577758;18801728;19105585;19876791;19929708;20381629;2069952;20966082;21036126;21076856;2163110;2212001;2417744;24687066;2491850;2553411;2553705;26417854;2871555;29443750;29602314;30779550;30833991;3127824;31279028;31399091;31983287;32226383;32497535;32540603;32618402;32715661;32983136;33049737;34561969;35051231;35932760;3616618;37664938;37712273;37815140;38632163;4474131;4509319;4521809;4721748;4833516;6085243;6220408;6950381;728431;7797503;7797535;7829495;8082781;8198617;8340388;8344299;8386612;8397094;8514797;8557170;8612563;8672451;8732687;8770894;8906787;9064337;9263355;9417641;9651336",
        "class_list": "",
        "function": "New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases. Review article, [RefSeq, PubMed]; Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion (PubMed:11604398, PubMed:35932760). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:18375760, PubMed:35932760). Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (PubMed:21076856)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Role of Parathyroid Hormone and Parathyroid Hormone-Related Protein in Protein-Energy Malnutrition. Review article, [RefSeq, PubMed]; The Relationship Between Atrial Fibrillation and Parathyroid Hormone in Heart Failure Outpatients. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]; [MiR-301a-5p modulates parathyroid hormone secretion in secondary hyperparathyroidism possibly by regulating calcium-sensing receptor]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 24,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VB48;Q9UD38",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0048018 receptor ligand activity;GO:0031857 type 1 parathyroid hormone receptor binding;GO:0031856 parathyroid hormone receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0046058 cAMP metabolic process;GO:1900158 negative regulation of bone mineralization involved in bone maturation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "P01270-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11498-1",
        "uniprot_id": [
            {
                "id": "PYC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11498",
                "type": "external"
            }
        ],
        "mass": 129634.0,
        "length": 1178,
        "protein_name": "Pyruvate carboxylase, mitochondrial",
        "gene_name": "PC",
        "organism": "Human",
        "refseq_name": "pyruvate carboxylase, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_000911",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000911",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PC",
        "gene_names_refseq": "PCB; PC",
        "protein_names_uniprotkb": "Pyruvate carboxylase, mitochondrial; 6.4.1.1; PCB; Pyruvic carboxylase",
        "protein_names_refseq": "pyruvate carboxylase, mitochondrial precursor; pyruvate carboxylase, mitochondrial; pyruvic carboxylase",
        "tax_id": 9606,
        "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); pyruvate carboxylase deficiency disease (Disease Ontology:DOID:3651)",
        "pathway": " (hsa:5091);  (R-HSA-196780);  (R-HSA-3371599);  (R-HSA-70263);  (R-HSA-70268)",
        "pathway_count": 5,
        "publication_count": 159,
        "publication_id_list": "10064314;10190325;10229653;10329687;10334869;10677481;10714828;11185745;11237011;11276087;11377399;11506403;11735028;11851336;11863375;11945601;12093795;12121650;12124727;12437512;12646417;1278465;12962632;12965222;14596586;14718531;14722102;14766011;15551868;15710582;15870898;16134170;16150625;17924679;18297087;18337460;18351441;183598;18449899;18613815;19118303;19306334;1931970;1935931;19608861;19679512;1993674;1996957;20068231;20153287;21156174;21183659;21949678;22123817;22628558;23284632;23438705;23481700;23506893;2440048;24715725;24998673;25202825;25575590;25594249;25645385;25880248;26992070;27166188;27317664;27726376;27846572;28228285;28510447;2868710;28904123;29331515;29393594;29472561;29557506;30397120;30429286;30484775;30779550;31154438;3170585;31844290;3208766;32119511;32157095;32161166;32357974;32387766;32403431;32488085;32938616;33064660;33214551;33298915;33537174;3355497;33912179;33968037;34105348;34185709;3435492;34357683;34725712;34764457;35051231;35083852;3529090;3555348;35580925;35907054;36010968;36215666;36241641;36417180;37217939;37873728;37938771;38086219;38665916;4822737;4827367;5009693;6434534;6548474;6771269;6883721;7144574;7391027;7509806;7573034;7717389;7732023;7757881;7818469;7842009;7918683;8048912;8211187;8447317;8571957;8645161;8726225;8817339;8930409;9119391;9382095;9428641;9585002;9585612;9630604;9657976;9678974;9705294;9758626",
        "class_list": "",
        "function": "Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment., [RefSeq, PubMed]; In silico Analysis of Two Novel Variants in the Pyruvate Carboxylase (PC) Gene Associated with the Severe Form of PC Deficiency., [RefSeq, PubMed]; Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase., [RefSeq, PubMed]; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate., [UniProtKB, PubMed]; The ubiquitous expression of pyruvate carboxylase among human prostate tumors., [RefSeq, PubMed]; This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DN00;Q16705",
        "ec_number_list": [
            {
                "id": "6.4.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3",
                "type": "external"
            },
            {
                "id": "6.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1",
                "type": "external"
            },
            {
                "id": "6.3.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-",
                "type": "external"
            },
            {
                "id": "6.3.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10",
                "type": "external"
            },
            {
                "id": "6.3.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11",
                "type": "external"
            },
            {
                "id": "6.3.4.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15",
                "type": "external"
            },
            {
                "id": "6.3.4.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9",
                "type": "external"
            },
            {
                "id": "6.4.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0009374 biotin binding;GO:0004736 pyruvate carboxylase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0019074 viral RNA genome packaging;GO:0006629 lipid metabolic process;GO:0010629 negative regulation of gene expression;GO:0006094 gluconeogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 16.3,
        "record_id": "P11498-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P17812-1",
        "uniprot_id": [
            {
                "id": "PYRG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P17812",
                "type": "external"
            }
        ],
        "mass": 66690.0,
        "length": 591,
        "protein_name": "CTP synthase 1",
        "gene_name": "CTPS1",
        "organism": "Human",
        "refseq_name": "CTP synthase 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001288166",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288166",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CTPS1; CTPS",
        "gene_names_refseq": "CTPS1; CTPS; GATD5A; GATD5; IMD24",
        "protein_names_uniprotkb": "CTP synthase 1; 3.5.1.-; 6.3.4.2; CTP synthetase 1; Protein-asparagine deamidase CTPS1; UTP--ammonia ligase 1",
        "protein_names_refseq": "CTP synthase 1 isoform b; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase; protein-asparagine deamidase CTPS1",
        "tax_id": 9606,
        "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); immunodeficiency 24 (Disease Ontology:DOID:0111938)",
        "pathway": " (hsa:1503);  (R-HSA-499943)",
        "pathway_count": 2,
        "publication_count": 142,
        "publication_id_list": "10215863;10453732;10618642;10716435;10799505;10884394;10899599;11237011;11277919;11278511;11517226;11796141;11912132;12972261;13211603;14729598;15630091;16179339;16373698;16756507;16820675;16964243;17081983;17189248;17320107;17322306;17463002;17487921;17681942;177353;17824959;18088087;18220336;18452278;18469;18491316;1851158;18635542;18669648;18691976;18707149;18767875;18997010;19176520;19220460;19413330;19415658;19608861;19651622;19664994;19664995;19690332;19766732;20058876;20068231;20230923;21080915;2113467;211388;211390;21406692;22847445;23186163;23301498;23416111;23481700;24503052;24870241;25223282;25418920;2542324;25892735;2656695;2668278;26811146;26929215;26992070;27600516;27846572;27920218;28063628;28459447;28510447;28649982;28832583;28834231;28904123;29242379;29393594;29632046;29671580;29786170;30192525;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32870666;32938616;33214551;33298915;33392160;33592498;33717175;33912179;33936100;33968037;34019948;34078123;34171305;34357683;34433824;34509645;34583994;34725712;35051231;35138101;35251023;35580925;36215666;36241641;38665916;39030877;39197579;40240600;40615;40914422;5484814;6182143;6248551;7685356;7851394;8448179;8530356;8663313;9247584;9488696;9677297",
        "class_list": "",
        "function": "CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids (PubMed:16179339, PubMed:17189248, PubMed:17463002, PubMed:24870241, PubMed:28459447, PubMed:34583994). Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen (PubMed:16179339, PubMed:24870241, PubMed:28459447, PubMed:34583994). CTPS1 CTP synthase activity plays a crucial role in the proliferation of activated lymphocytes and immunity; additional CTP being required to meet increased demand for DNA, RNA and lipid membrane biosynthesis in proliferating lymphocytes (PubMed:24870241, PubMed:8530356). In addition to CTP synthase activity, also acts as a protein deamidase that catalyzes the side chain deamidation of specific asparagine residues of proteins to aspartate (PubMed:40240600). Acts as a negative regulator of innate immunity by mediating deamidation of 'Asn-85' of IRF3, preventing IRF3 from binding DNA (By similarity). Facilitates chromatin relaxation in response to DNA damage by mediating deamidation of 'Asn-76' and 'Asn-77' of histone H1, thereby promoting subsequent acetylation of histone H1 at 'Lys-75' (H1K75ac), increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins (PubMed:40240600)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-519e-5p regulates malignant phenotype of breast cancer cells through binding to CTPS1., [RefSeq, PubMed]; The role of cytidine 5'-triphosphate synthetase 1 in metabolic rewiring during epithelial-to-mesenchymal transition in non-small-cell lung cancer., [RefSeq, PubMed]; This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DR64;D3DPW1;Q5VW67;Q96GK6",
        "ec_number_list": [
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "6.3.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0003883 CTP synthase activity;GO:0160260 protein asparagine deamidase activity;GO:0160264 histone H1N76/N77 asparagine deamidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0000785 chromatin",
        "go_biological_process": "GO:1902340 negative regulation of chromosome condensation;GO:0009410 response to xenobiotic stimulus;GO:0006139 nucleobase-containing compound metabolic process;GO:0044210 'de novo' CTP biosynthetic process;GO:0042100 B cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "P17812-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P30520-1",
        "uniprot_id": [
            {
                "id": "PURA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30520",
                "type": "external"
            }
        ],
        "mass": 50097.0,
        "length": 456,
        "protein_name": "Adenylosuccinate synthetase isozyme 2",
        "gene_name": "ADSS2",
        "organism": "Human",
        "refseq_name": "adenylosuccinate synthetase isozyme 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001117",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001117",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ADSS2; ADSS",
        "gene_names_refseq": "ADEH; ADSS 2; ADSS2; ADSS",
        "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase",
        "protein_names_refseq": "AMPSase 2; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase; adenylosuccinate synthetase (Ade(-)H-complementing); adenylosuccinate synthetase isozyme 2 isoform 1; adenylosuccinate synthetase, acidic isozyme; adenylosuccinate synthetase, liver isozyme; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "sarcoma (Disease Ontology:DOID:1115)",
        "pathway": " (hsa:159);  (R-HSA-73817)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10958654;11096114;11381136;12450384;14529546;14978097;15786719;1592113;17224163;18388293;18609073;1967654;21320556;2147474;2183217;21960835;23481700;24029068;24366607;24715725;25367160;25505266;25576301;25645385;25802875;25880248;26154972;26992070;27846572;27920218;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30524438;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34229054;34357683;34509645;34725712;34932366;35051231;35138101;35251023;35318648;35561310;35580925;36010968;36241641;36284347;36581221;37938771;38665916;40596516;40914422;4348202;4726295;762062;7706277;7903306;8089153;8110788;8366112;8380692;8567683",
        "class_list": "",
        "function": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP., [UniProtKB, UniProtKB]; This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AQM5;Q96EG7",
        "ec_number_list": [
            {
                "id": "6.3.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0014074 response to purine-containing compound;GO:0046040 IMP metabolic process;GO:0006531 aspartate metabolic process;GO:0071257 cellular response to electrical stimulus;GO:0006167 AMP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P30520-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14761-1",
        "uniprot_id": [
            {
                "id": "PTCA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14761",
                "type": "external"
            }
        ],
        "mass": 21196.0,
        "length": 206,
        "protein_name": "Protein tyrosine phosphatase receptor type C-associated protein",
        "gene_name": "PTPRCAP",
        "organism": "Human",
        "refseq_name": "protein tyrosine phosphatase receptor type C-associated protein",
        "refseq_ac": [
            {
                "id": "NP_005599",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005599",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRCAP; LPAP",
        "gene_names_refseq": "CD45-AP; LPAP; PTPRCAP",
        "protein_names_uniprotkb": "Protein tyrosine phosphatase receptor type C-associated protein; CD45-AP; CD45-associated protein; Lymphocyte phosphatase-associated phosphoprotein; PTPRC-associated protein",
        "protein_names_refseq": "CD45 associated protein; PTPRC-associated protein; lymphocyte phosphatase-associated phosphoprotein; protein tyrosine phosphatase receptor type C-associated protein; protein tyrosine phosphatase, receptor type, c polypeptide-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5790)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "15372250;19367720;20019842;20166139;21872626;21993680;22299025;23481700;24275569;25502872;26154972;26992070;27846572;27920218;28218747;28228285;28467828;28827793;28832583;28834231;28904123;29242379;29314611;29393594;29437277;29493099;29508533;29632711;30315122;30482149;31530632;31537385;31661482;31844290;32265295;32502341;32938616;33298915;33633747;33691108;33717175;33936100;34357683;34433824;34932366;35154160;38253038;40914422;7961877;8537410;8954783",
        "class_list": "",
        "function": "Data show that the minor allele of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; LPAP is a substrate for protein kinase CK2 that phosphorylates it at Ser153, presumably ensuring LPAP resistance to degradation., [RefSeq, PubMed]; Results support the model: following phorbol 12-myristate 13-acetate (PMA) or TCR/CD3 activation of T cells, LPAP is rapidly dephosphorylated at Ser-99 and Ser-172 and slowly phosphorylated at Ser-163. Ser-153 exhibited a high basal level of phosphorylation in both resting and activated cells Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]., [RefSeq]; We analysed the C77G polymorphism in multiple sclerosis (MS) patients from the genetically homogeneous population of Sardinia. CD45 did not contribute to development of the disease in Sardinian MS., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R512;O00643;Q6I9S6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006952 defense response",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q14761-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3KNS1-1",
        "uniprot_id": [
            {
                "id": "PTHD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3KNS1",
                "type": "external"
            }
        ],
        "mass": 107689.0,
        "length": 954,
        "protein_name": "Patched domain-containing protein 3",
        "gene_name": "PTCHD3",
        "organism": "Human",
        "refseq_name": "patched domain-containing protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001030014",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030014",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTCHD3; PTR",
        "gene_names_refseq": "PTCHD3; PTR; SLC65C3",
        "protein_names_uniprotkb": "Patched domain-containing protein 3; Patched-related protein",
        "protein_names_refseq": "patched domain-containing protein 3 isoform 1; patched domain-containing protein 3; patched-related protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374308)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "17904097;19664994;21439084;25892735;26374642;29242379;31154438",
        "class_list": "",
        "function": "May play a role in sperm development or sperm function (PubMed:17904097). However, does not appear to have an essential role in spermatogenesis or male fertility (PubMed:21439084)., [UniProtKB, PubMed, PubMed]; PTCHD3 nulls: rare copy number and sequence variants suggest a non-essential gene. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function., [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F6LPT1;I3L499;Q6ZU28",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0097225 sperm midpiece",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q3KNS1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.010000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5FWE3-1",
        "uniprot_id": [
            {
                "id": "PRRT3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5FWE3",
                "type": "external"
            }
        ],
        "mass": 102197.0,
        "length": 981,
        "protein_name": "Proline-rich transmembrane protein 3",
        "gene_name": "PRRT3",
        "organism": "Human",
        "refseq_name": "proline-rich transmembrane protein 3 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001305800",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305800",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRRT3; PRO19642",
        "gene_names_refseq": "PRRT3",
        "protein_names_uniprotkb": "Proline-rich transmembrane protein 3",
        "protein_names_refseq": "proline-rich transmembrane protein 3 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285368)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;12975309;15340161;19664994;23186163;23234360;23584533;24715725;25502872;25576301;25645385;26154972;27846572;28467828;28832583;29242379;30459171;30573663;31217245;32161166;32350084;32938616;33592498;34357683;34433824;35051231;35154160;35251023;35494241",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49AD0;Q6UXY6;Q8NBC9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q5FWE3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PGN9-1",
        "uniprot_id": [
            {
                "id": "PSRC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PGN9",
                "type": "external"
            }
        ],
        "mass": 38796.0,
        "length": 363,
        "protein_name": "Proline/serine-rich coiled-coil protein 1",
        "gene_name": "PSRC1",
        "organism": "Human",
        "refseq_name": "proline/serine-rich coiled-coil protein 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001005290",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005290",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSRC1; DDA3; FP3214",
        "gene_names_refseq": "DDA3; FP3214; PSRC1",
        "protein_names_uniprotkb": "Proline/serine-rich coiled-coil protein 1",
        "protein_names_refseq": "differential display and activated by p53; p53-regulated DDA3; proline/serine-rich coiled-coil 1; proline/serine-rich coiled-coil protein 1 isoform b; proline/serine-rich coiled-coil protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84722)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;12427559;15498874;16964243;18220336;18291097;18411309;18669648;19690332;19738423;20068231;20117088;21406692;23186163;23481700;24715725;25576301;26154972;26820536;26992070;27697924;27862975;28832583;28904123;29242379;29485866;29557506;29714125;30379171;31844290;31998317;32157095;32502341;32620998;32789689;32858814;32938616;33141586;33298915;33592498;35051231;36010968",
        "class_list": "",
        "function": "Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population. Publication Status: Online-Only, [RefSeq, PubMed]; DDA3 represents a new class of microtubule-destabilizing protein that controls spindle dynamics and mitotic progression by regulating microtubule depolymerases., [RefSeq, PubMed]; Genetically programmed changes in transcription of the novel progranulin regulator., [RefSeq, PubMed]; Molecular cloning, sequence analysis and gene expression, [RefSeq, PubMed]; Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length., [RefSeq, PubMed]; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression., [UniProtKB, PubMed, PubMed, PubMed]; The frequency of SNP rs599839 located in the 3' UTR of the PSRC1 gene in patients with genetically confirmed diagnosis of heterozygous familial hypercholesterolemia was analyzed. It was found that there was no association between rs599839 alleles and coronary heart disease in the multivariate analysis., [RefSeq, PubMed]; This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]., [RefSeq]; Together our results show that hDDA3 is a p53- and DNA-damage down-regulated target that exhibits oncogenic characteristics., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T2Z3;Q6ZTI8;Q71MG3;Q9BV77",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0051301 cell division;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0007080 mitotic metaphase chromosome alignment;GO:0031116 positive regulation of microtubule polymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q6PGN9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UX71-1",
        "uniprot_id": [
            {
                "id": "PXDC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UX71",
                "type": "external"
            }
        ],
        "mass": 59583.0,
        "length": 529,
        "protein_name": "Plexin domain-containing protein 2",
        "gene_name": "PLXDC2",
        "organism": "Human",
        "refseq_name": "plexin domain-containing protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001269665",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269665",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXDC2; PRO6003; TEM7R",
        "gene_names_refseq": "PLXDC2-OT; PLXDC2; TEM7R",
        "protein_names_uniprotkb": "Plexin domain-containing protein 2; Tumor endothelial marker 7-related protein",
        "protein_names_refseq": "1200007L24Rik; plexin domain-containing protein 2 isoform 2; plexin domain-containing protein 2; tumor endothelial marker 7-related protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84898)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11559528;12975309;15574754;16335952;19159218;19367720;19531498;19651622;20166139;21081667;21406692;23090970;23584533;24190977;25576301;26154972;26992070;27090790;27726376;28904123;29557506;29741879;30429286;30459171;31611695;32157095;32162841;32387766;32938616;32983136;33043033;33592498;33657166;33968037;34078123;34087483;34146255;34433824;34777633;34932366;35051231;35580925;36284347;37074911;37089864;37938771;40930100",
        "class_list": "",
        "function": "Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in tumor angiogenesis., [UniProtKB, PubMed]; Plexin domain containing protein 2 is more expressed within the invasive area of human colorectal cancer tissues., [RefSeq, PubMed]; Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). Publication Status: Online-Only, [RefSeq, PubMed]; The Upregulation of PLXDC2 Correlates with Immune Microenvironment Characteristics and Predicts Prognosis in Gastric Cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 31,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96E59;Q96PD9;Q96SU9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0016604 nuclear body",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q6UX71-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7RTY5-2",
        "uniprot_id": [
            {
                "id": "PRS48_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7RTY5",
                "type": "external"
            }
        ],
        "mass": 35970.0,
        "length": 328,
        "protein_name": "Serine protease 48",
        "gene_name": "PRSS48",
        "organism": "Human",
        "refseq_name": "serine protease 48 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_899231",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899231",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRSS48; ESSPL",
        "gene_names_refseq": "ESSPL; PRSS48",
        "protein_names_uniprotkb": "Serine protease 48; 3.4.21.-; Epidermis-specific serine protease-like protein",
        "protein_names_refseq": "epidermis-specific serine protease-like protein; protease, serine 48; serine protease 48 isoform 1 precursor; testicular tissue protein Li 65",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:345062)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "12838346;29557506;35051231;35251023;37074911",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 12,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q08E82;Q0VAD4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q7RTY5-2",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IV42-1",
        "uniprot_id": [
            {
                "id": "PSTK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IV42",
                "type": "external"
            }
        ],
        "mass": 39527.0,
        "length": 348,
        "protein_name": "L-seryl-tRNA(Sec) kinase",
        "gene_name": "PSTK",
        "organism": "Human",
        "refseq_name": "L-seryl-tRNA(Sec) kinase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_699167",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_699167",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSTK; C10orf89",
        "gene_names_refseq": "C10orf89; PSTK",
        "protein_names_uniprotkb": "L-seryl-tRNA(Sec) kinase; 2.7.1.164; O-phosphoseryl-tRNA(Sec) kinase",
        "protein_names_refseq": "L-seryl-tRNA(Sec) kinase isoform 2; L-seryl-tRNA(Sec) kinase; O-phosphoseryl-tRNA(Sec) kinase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:118672);  (R-HSA-2408557)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10970870;11237011;11265756;15317934;15534230;15821744;17142313;19608919;20877624;25892735;28904123;29769354;30379171;31844290;32157095;33417976;33968037;35154160;8890909;9431993;9637248",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Same but different - Molecular comparison of human KTI12 and PSTK., [RefSeq, PubMed]; Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. No activity with other tRNAs has been detected., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZSS9",
        "ec_number_list": [
            {
                "id": "2.7.1.164",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.164",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0016301 kinase activity;GO:0043915 L-seryl-tRNA(Sec) kinase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8IV42-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N8N7-1",
        "uniprot_id": [
            {
                "id": "PTGR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N8N7",
                "type": "external"
            }
        ],
        "mass": 38499.0,
        "length": 351,
        "protein_name": "Prostaglandin reductase 2",
        "gene_name": "PTGR2",
        "organism": "Human",
        "refseq_name": "prostaglandin reductase 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001139626",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139626",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTGR2; ZADH1",
        "gene_names_refseq": "HEL-S-298; PGR2; PTGR2; ZADH1",
        "protein_names_uniprotkb": "Prostaglandin reductase 2; 1.3.1.48; 15-oxoprostaglandin 13-reductase; PRG-2; Zinc-binding alcohol dehydrogenase domain-containing protein 1",
        "protein_names_refseq": "15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin-delta13-reductase; PRG-2; epididymis secretory protein Li 298; epididymis secretory sperm binding protein; prostaglandin reductase 2 isoform 1; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:145482);  (R-HSA-2162123)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10377455;10622721;10922363;10966456;11237011;11297515;11465543;11672424;12627223;12835322;1380156;14979715;15004468;15047184;15115769;16475787;16828555;17449869;17641676;18006499;18493841;18682561;19000823;20036328;20068231;20667974;20877624;20950588;21467029;22998775;23301498;26820738;26992070;29557506;30484775;31844290;32350084;33912179;35051231;36241641;3862115;3954355;4514999;4521806;4776443;5284360;7005231;7552725;7925341;7947975;8175750;8901870;9139685;9219313;9626023",
        "class_list": "",
        "function": "Besides targeting cyclooxygenase, indomethacin inhibits PTGR2 with a binding mode similar to that of 15-keto-PGE(2)., [RefSeq, PubMed]; Cloning and tissue distribution of a splicing variant ZADH1b., [RefSeq, PubMed]; Functional data and clinical relevance for the role of PTGR2 in gastric cancer, are provided., [RefSeq, PubMed]; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Silencing of PTGR2 expression enhances reactive oxygen species production, suppresses pancreatic cell proliferation, and promotes cell death through increasing 15-keto-PGE2. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3L8A4;Q6MZH8",
        "ec_number_list": [
            {
                "id": "1.3.1.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74",
                "type": "external"
            },
            {
                "id": "1.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006693 prostaglandin metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q8N8N7-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BQI7-1",
        "uniprot_id": [
            {
                "id": "PSD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BQI7",
                "type": "external"
            }
        ],
        "mass": 84660.0,
        "length": 771,
        "protein_name": "PH and SEC7 domain-containing protein 2",
        "gene_name": "PSD2",
        "organism": "Human",
        "refseq_name": "PH and SEC7 domain-containing protein 2",
        "refseq_ac": [
            {
                "id": "NP_115665",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115665",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSD2; EFA6C",
        "gene_names_refseq": "EFA6C; PSD2",
        "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 2; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C; Exchange factor for ARF6 C; Pleckstrin homology and SEC7 domain-containing protein 2",
        "protein_names_refseq": "PH and SEC7 domain-containing protein 2; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C; exchange factor for ARF6 C; pleckstrin homology and SEC7 domain-containing protein 2",
        "tax_id": 9606,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:84249)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11230166;11237011;18452278;19664994;28218747;28738127;29084334;29557506;32938616;33298915;33981976;35051231;35580925;39894887",
        "class_list": "",
        "function": "Brain gene expression of PADI2, ZNF385A, PSD2, and A2ML1 and DNA methylation dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions., [RefSeq, PubMed]; PSD2 may be involved in endolysosomal transport-a process known to be important to development of early onset AD., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQD3;Q8N3J8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0098794 postsynapse;GO:0032154 cleavage furrow",
        "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9BQI7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BRX5-1",
        "uniprot_id": [
            {
                "id": "PSF3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BRX5",
                "type": "external"
            }
        ],
        "mass": 24535.0,
        "length": 216,
        "protein_name": "DNA replication complex GINS protein PSF3",
        "gene_name": "GINS3",
        "organism": "Human",
        "refseq_name": "DNA replication complex GINS protein PSF3 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001119601",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119601",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GINS3; PSF3",
        "gene_names_refseq": "GINS3; MGORS9; PSF3",
        "protein_names_uniprotkb": "DNA replication complex GINS protein PSF3; GINS complex subunit 3",
        "protein_names_refseq": "DNA replication complex GINS protein PSF3 isoform a; DNA replication complex GINS protein PSF3; GINS complex subunit 3 (Psf3 homolog)",
        "tax_id": 9606,
        "disease": "Meier-Gorlin syndrome 9 (Disease Ontology:DOID:0051069); Meier-Gorlin syndrome (Disease Ontology:DOID:0060306)",
        "pathway": " (hsa:64785);  (R-HSA-176974)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "12730134;16990792;17127213;17170760;17417653;17545466;17557111;17652513;23481700;24715725;25576301;26154972;26375851;26992070;27846572;28414293;28832583;28834231;28904123;29242379;30429286;30833945;31844290;31998317;32157095;32357974;32453425;32488085;32897882;32938616;33141586;33298915;33936100;33968037;33981976;34087483;34694004;34700328;35051231;35561310;35580925;35585232;35603789;35896011;36241641;38773883",
        "class_list": "",
        "function": "Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma., [RefSeq, PubMed]; Expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1, [RefSeq, PubMed]; Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293, PubMed:35603789). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; This paper describes work done in Saccharomyces cerevisiae., [RefSeq, PubMed]; This paper describes work done in Schizosaccharomyces pombe., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDP3;E9PB21;Q9H870",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex",
        "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q9BRX5-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BT73-1",
        "uniprot_id": [
            {
                "id": "PSMG3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BT73",
                "type": "external"
            }
        ],
        "mass": 13104.0,
        "length": 122,
        "protein_name": "Proteasome assembly chaperone 3",
        "gene_name": "PSMG3",
        "organism": "Human",
        "refseq_name": "proteasome assembly chaperone 3",
        "refseq_ac": [
            {
                "id": "NP_001127812",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127812",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMG3; C7orf48; PAC3",
        "gene_names_refseq": "C7orf48; PAC3; PSMG3; Pba3",
        "protein_names_uniprotkb": "Proteasome assembly chaperone 3; PAC-3; Pba3; Proteasome chaperone homolog 3; hPAC3",
        "protein_names_refseq": "PAC-3; hPAC3; proteasome (prosome, macropain) assembly chaperone 3; proteasome assembling chaperone 3; proteasome assembly chaperone 3; proteasome chaperone homolog 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84262);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10973495;15831487;16251969;16990800;17189198;17540904;17948026;18278057;19490896;20068231;20471946;22223895;23301498;23481700;23495936;24715725;28263418;28442575;28510447;28598414;28855257;28904123;29093164;29242379;29557506;30524438;30779550;31844290;32161166;32897882;32938616;33691108;33981976;34126152;34171305;34932366;35051231;35561310;35580925;36241641;37938771",
        "class_list": "",
        "function": "Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3., [RefSeq, PubMed]; Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes., [UniProtKB, PubMed]; We report the identification of a chaperone, designated PAC3, as a component of alpha rings. PAC3 dissociates before the formation of half-proteasomes, a process coupled with the recruitment of beta subunits and hUmp1.[PAC3], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D216;A8MPW2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0080129 proteasome core complex assembly;GO:0051131 chaperone-mediated protein complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q9BT73-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H606-1",
        "uniprot_id": [
            {
                "id": "PRORY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H606",
                "type": "external"
            }
        ],
        "mass": 19976.0,
        "length": 182,
        "protein_name": "Proline-rich protein, Y-linked",
        "gene_name": "PRORY",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PRORY; CYorf17",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Proline-rich protein, Y-linked",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q9H606-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZH4-1",
        "uniprot_id": [
            {
                "id": "PTTG3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZH4",
                "type": "external"
            }
        ],
        "mass": 22064.0,
        "length": 202,
        "protein_name": "Putative pituitary tumor-transforming gene 3 protein",
        "gene_name": "PTTG3P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PTTG3P; PTTG3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative pituitary tumor-transforming gene 3 protein; Securin-3; hPTTG3; rcPTTG1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 14,
        "publication_id_list": "10806349;16201836;27600516;27920218;28832583;28834231;29093164;29242379;29393594;29557506;31154438;33981976;35051231;37340703",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95356",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004869 cysteine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0051276 chromosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9NZH4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZH5-1",
        "uniprot_id": [
            {
                "id": "PTTG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZH5",
                "type": "external"
            }
        ],
        "mass": 22302.0,
        "length": 202,
        "protein_name": "Securin-2",
        "gene_name": "PTTG2",
        "organism": "Human",
        "refseq_name": "securin-2",
        "refseq_ac": [
            {
                "id": "NP_006598",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006598",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTTG2",
        "gene_names_refseq": "PTTG2",
        "protein_names_uniprotkb": "Securin-2; Pituitary tumor-transforming gene 2 protein",
        "protein_names_refseq": "pituitary tumor-transforming gene 2 protein; securin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10744)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10084610;10656688;10806349;23470537;26617803;26992070;29557506;31848261;31937595;31998317;32157095;32161166;33968037;34211107;34509645;34932366;35051231;35318648;36241641",
        "class_list": "",
        "function": "Knockdown of PTTG2 results in concomitant downregulation of E-cadherin and elevated vimentin levels, consistent with epithelial-to-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; PTTG2 induces psoriasis by regulating epidermal expression of vimentin and E-cadherin. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95355;Q6NTC9;Q9UNJ6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004869 cysteine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0051276 chromosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9NZH5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "C9J798-1",
        "uniprot_id": [
            {
                "id": "RAS4B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/C9J798",
                "type": "external"
            }
        ],
        "mass": 90406.0,
        "length": 803,
        "protein_name": "Ras GTPase-activating protein 4B",
        "gene_name": "RASA4B",
        "organism": "Human",
        "refseq_name": "ras GTPase-activating protein 4B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001354696",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001354696",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RASA4B",
        "gene_names_refseq": "RASA4B",
        "protein_names_uniprotkb": "Ras GTPase-activating protein 4B",
        "protein_names_refseq": "putative Ras GTPase-activating protein 4B; ras GTPase-activating protein 4B isoform 2; ras GTPase-activating protein 4B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100271927)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;24714562;26154972;27846572;28904123;29493099;30315122;31844290;32350084;32357974;32387766;32938616;33298915;33691108;33968037;34405274;34509645;35051231;35494241;35580925;36010968;37938771",
        "class_list": "",
        "function": "Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:0071277 cellular response to calcium ion;GO:1902531 regulation of intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "C9J798-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31930-1",
        "uniprot_id": [
            {
                "id": "QCR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31930",
                "type": "external"
            }
        ],
        "mass": 52646.0,
        "length": 480,
        "protein_name": "Cytochrome b-c1 complex subunit 1, mitochondrial",
        "gene_name": "UQCRC1",
        "organism": "Human",
        "refseq_name": "cytochrome b-c1 complex subunit 1, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_003356",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003356",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UQCRC1",
        "gene_names_refseq": "D3S3191; PKNPY; QCR1; UQCR1; UQCRC1",
        "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1",
        "protein_names_refseq": "complex III subunit 1; core protein I; cytochrome b-c1 complex subunit 1, mitochondrial precursor; cytochrome b-c1 complex subunit 1, mitochondrial; ubiquinol-cytochrome c reductase core protein I; ubiquinol-cytochrome-c reductase complex core protein 1",
        "tax_id": 9606,
        "disease": "multiple mitochondrial dysfunctions syndrome 6 (Disease Ontology:DOID:0070332); Alzheimer's disease (Disease Ontology:DOID:10652); parkinsonism with polyneuropathy (MONDO:MONDO:0036193)",
        "pathway": " (hsa:7384);  (R-HSA-611105);  (R-HSA-9865881)",
        "pathway_count": 3,
        "publication_count": 76,
        "publication_id_list": "10327278;10453733;11237011;11695836;12231006;12837546;1327877;14741580;15242332;15250827;16230336;17033964;17924679;186667;19608861;20068231;21278747;23150584;23168492;23270816;23564345;23747254;239860;24385928;25008109;25418920;25564869;25605331;26853435;27452731;28228285;28380382;28673544;28832583;28844695;28904123;29242379;29243944;29557506;30315122;30573663;31217245;31844290;32119511;32157095;32161166;32161263;32870666;32929120;32938616;32983136;33141179;33248804;33392160;33592498;33717175;33912179;33968037;34229054;34357683;34725712;34932366;34969438;35051231;36215666;36241641;37074911;37984314;38665916;39302247;40914422;4288886;8069229;8313870;8407948;9878551",
        "class_list": "",
        "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Lack of evidence for association of UQCRC1 with Parkinson's disease in Europeans., [RefSeq, PubMed]; Rare variant analysis of UQCRC1 in Chinese patients with early-onset Parkinson's disease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7R8;Q96DD2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0008121 quinol-cytochrome-c reductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0017087 mitochondrial processing peptidase complex;GO:0098803 respiratory chain complex",
        "go_biological_process": "GO:0043279 response to alkaloid;GO:0014823 response to activity;GO:0006119 oxidative phosphorylation;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "P31930-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14957-1",
        "uniprot_id": [
            {
                "id": "QCR10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14957",
                "type": "external"
            }
        ],
        "mass": 6570.0,
        "length": 56,
        "protein_name": "Cytochrome b-c1 complex subunit 10",
        "gene_name": "UQCR11",
        "organism": "Human",
        "refseq_name": "cytochrome b-c1 complex subunit 10",
        "refseq_ac": [
            {
                "id": "NP_006821",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006821",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UQCR11; UQCR",
        "gene_names_refseq": "0710008D09Rik; QCR10; UQCR11; UQCR",
        "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 10; Complex III subunit 10; Complex III subunit XI; Ubiquinol-cytochrome c reductase complex 6.4 kDa protein",
        "protein_names_refseq": "complex III subunit 10; complex III subunit XI; cytochrome b-c1 complex subunit 10; ubiquinol-cytochrome c reductase complex 6.4 kDa protein; ubiquinol-cytochrome c reductase, 6.4kDa subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10975);  (R-HSA-611105);  (R-HSA-9865881)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "10327278;11695836;12231006;12837546;1327877;14741580;15250827;16230336;17033964;186667;19531498;20877624;21278747;23150584;23168492;23270816;23564345;23747254;239860;24385928;25008109;25418920;25564869;25605331;27846572;27920218;28380382;28673544;28844695;28904123;29243944;29393594;29557506;29632046;30315122;30484775;31530632;31611695;31844290;31848261;32161166;32387766;32929120;32938616;33392160;33592498;33936100;33968037;34171305;34357683;34561969;34969438;35580925;36241641;37938771;38459019;4288886;9161705;9878551",
        "class_list": "",
        "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability., [UniProtKB, UniProtKB]; N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R542;D6W5Z4;Q9UEA3;Q9UPK4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0009055 electron transfer activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III",
        "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "O14957-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75884-1",
        "uniprot_id": [
            {
                "id": "RBBP9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75884",
                "type": "external"
            }
        ],
        "mass": 21000.0,
        "length": 186,
        "protein_name": "Serine hydrolase RBBP9",
        "gene_name": "RBBP9",
        "organism": "Human",
        "refseq_name": "serine hydrolase RBBP9",
        "refseq_ac": [
            {
                "id": "NP_006597",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006597",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBBP9; BOG; RBBP10",
        "gene_names_refseq": "BOG; RBBP10; RBBP9",
        "protein_names_uniprotkb": "Serine hydrolase RBBP9; 3.1.-.-; B5T-overexpressed gene protein; Protein BOG; RBBP-10; RBBP-9; Retinoblastoma-binding protein 10; Retinoblastoma-binding protein 9",
        "protein_names_refseq": "B5T overexpressed gene protein; RBBP-10; RBBP-9; putative hydrolase RBBP9; retinoblastoma-binding protein 10; retinoblastoma-binding protein 9; retinoma-binding protein 9; serine hydrolase RBBP9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10741)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "12296629;19004028;19329999;20080647;21689726;21933118;22430187;32157095;32196348;32350084;32938616;33968037;36639418;39894887;9697699",
        "class_list": "",
        "function": "Blood samples of lateral sclerosis patients were found to have significantly different levels of expression of CyFIP2 and RbBP9 compared to the levels of expression in control subjects., [RefSeq, PubMed]; Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; RBBP10 was expressed widely in various human tissues, and the expression level is somewhat higher in tumor tissues than in normal tissues., [RefSeq, PubMed]; Serine hydrolase (Probable) (PubMed:32196348). Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir (PubMed:32196348). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Structure- function studies of RBBP9 suggest possible routes for novel cancer drug discovery programs. Review article, [RefSeq, PubMed]; The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DW31;Q5JPH9;Q9H1D8",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0017171 serine hydrolase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006805 xenobiotic metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "O75884-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75901-1",
        "uniprot_id": [
            {
                "id": "RASF9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75901",
                "type": "external"
            }
        ],
        "mass": 50021.0,
        "length": 435,
        "protein_name": "Ras association domain-containing protein 9",
        "gene_name": "RASSF9",
        "organism": "Human",
        "refseq_name": "ras association domain-containing protein 9",
        "refseq_ac": [
            {
                "id": "NP_005438",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005438",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RASSF9; PAMCI; PCIP1",
        "gene_names_refseq": "P-CIP1; PAMCI; PCIP1; RASSF9",
        "protein_names_uniprotkb": "Ras association domain-containing protein 9; P-CIP1; PAM COOH-terminal interactor protein 1; Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor",
        "protein_names_refseq": "PAM COOH-terminal interactor protein 1; Ras association (RalGDS/AF-6) domain family (N-terminal) member 9; peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor protein-1; ras association domain-containing protein 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9182)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "18272789;27760139;29557506;29789417;30132526;30429286;33051258;33717835;34171305;37217939;39531497;9837933",
        "class_list": "",
        "function": "May play a role in regulating vesicuar trafficking in cells., [UniProtKB]; Our analysis revealed 10 sun-exposure-dependent gene expression quantitative trait loci (se-eQTLs), including genes involved in skin pigmentation (SLC45A2) and epidermal differentiation (RASSF9). Publication Status: Online-Only, [RefSeq, PubMed]; RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. Publication Status: Online-Only, [RefSeq, PubMed]; RASSF9 is a direct target of miR-1254 in breast cancer., [RefSeq, PubMed]; The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMQ4;Q8N5U8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0012510 trans-Golgi network transport vesicle membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006605 protein targeting;GO:0016197 endosomal transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "O75901-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C7P1-1",
        "uniprot_id": [
            {
                "id": "RBY1D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7P1",
                "type": "external"
            }
        ],
        "mass": 55775.0,
        "length": 496,
        "protein_name": "RNA-binding motif protein, Y chromosome, family 1 member D",
        "gene_name": "RBMY1D",
        "organism": "Human",
        "refseq_name": "RNA-binding motif protein, Y chromosome, family 1 member D isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001006120",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006120",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBMY1D",
        "gene_names_refseq": "RBM1; RBM2; RBMY1D; YRRM1; YRRM2; hRBMY",
        "protein_names_uniprotkb": "RNA-binding motif protein, Y chromosome, family 1 member D",
        "protein_names_refseq": "RNA-binding motif protein 1; RNA-binding motif protein 2; RNA-binding motif protein, Y chromosome, family 1 member D isoform 1; RNA-binding motif protein, Y chromosome, family 1 member D; Y chromosome RNA recognition motif 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:378949)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis., [UniProtKB]; This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZMD9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005681 spliceosomal complex",
        "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0C7P1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P24386-1",
        "uniprot_id": [
            {
                "id": "RAE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P24386",
                "type": "external"
            }
        ],
        "mass": 73476.0,
        "length": 653,
        "protein_name": "Rab proteins geranylgeranyltransferase component A 1",
        "gene_name": "CHM",
        "organism": "Human",
        "refseq_name": "rab proteins geranylgeranyltransferase component A 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_000381",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000381",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CHM; REP1; TCD",
        "gene_names_refseq": "CHM; DXS540; GGTA; HSD-32; REP-1; TCD",
        "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A 1; Choroideremia protein; REP-1; Rab escort protein 1; TCD protein",
        "protein_names_refseq": "CHM, Rab escort protein 1; choroideremia (Rab escort protein 1); rab proteins geranylgeranyltransferase component A 1 isoform a; rab proteins geranylgeranyltransferase component A 1",
        "tax_id": 9606,
        "disease": "choroideremia (Disease Ontology:DOID:9821)",
        "pathway": " (hsa:1121);  (R-HSA-6803205);  (R-HSA-8873719);  (R-HSA-8876198)",
        "pathway_count": 4,
        "publication_count": 273,
        "publication_id_list": "10733530;10818110;10990452;11038176;11054413;11141079;11179213;11389151;11447212;11516400;11675392;11684014;11689439;11703925;11714700;11746448;11784320;11917121;11919562;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;1321151;14614825;14729977;15096524;15138286;1516130;15247254;15377670;15388334;1549574;15528189;15561770;15577913;15692570;15797384;15837622;15878329;15914536;15958533;15958553;1598901;16140933;16207721;16249378;16373702;16401880;16410077;1648736;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17114793;17132146;17189207;17208202;17239822;17287340;17287728;17411337;17442733;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18532927;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19040420;1904992;19109890;19345684;19349281;19403694;19413330;19427510;19490898;19549844;19562805;19603039;19620288;19656848;19725050;19729655;19745841;20008558;20068231;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21905166;21951725;22013193;22065758;22072793;2215697;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22694141;22705394;22762500;22908308;22983554;23059823;23084991;23091056;23147242;23176487;23176493;23182941;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23671130;23678941;23684622;23713133;23839779;24023390;24260043;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25418920;25469497;25472813;25576301;25645385;25648148;25713415;25925668;26055712;26154972;26177209;26245486;26434594;26538022;26811146;26925400;26936971;26969162;26992070;27041585;27044746;27103185;27246931;27329675;27920218;28228285;28834231;28904123;29314611;29393594;29632046;30410026;30620550;31844290;32157095;32265295;32350084;32357974;32387766;32488085;33592498;33968037;33981976;34357683;35051231;35580925;36010968;36241641;36413603;37217939;37938771;37989423;7688123;7911226;7951216;7957092;7981670;7991565;8144603;8164745;8349690;8375503;8408203;8513495;8522602;8631982;8662963;8836150;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE., [RefSeq, PubMed]; Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia., [RefSeq, PubMed]; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation., [UniProtKB, PubMed, PubMed]; This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4D2;O43732",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004663 Rab geranylgeranyltransferase activity;GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0007601 visual perception;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 27.6,
        "record_id": "P24386-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P61574-1",
        "uniprot_id": [
            {
                "id": "RE113_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P61574",
                "type": "external"
            }
        ],
        "mass": 11828.0,
        "length": 105,
        "protein_name": "Endogenous retrovirus group K member 113 Rec protein",
        "gene_name": "HERVK_113",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HERVK_113",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 113 Rec protein; HERV-K113 Rec protein; HERV-K_19p13.11 provirus Rec protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "11591322;15063128",
        "class_list": "",
        "function": "Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity)., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051028 mRNA transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P61574-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P61578-1",
        "uniprot_id": [
            {
                "id": "REC16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P61578",
                "type": "external"
            }
        ],
        "mass": 11808.0,
        "length": 105,
        "protein_name": "Endogenous retrovirus group K member 16 Rec protein",
        "gene_name": "ERVK-16",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "ERVK-16",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 16 Rec protein; HERV-K_10p14 provirus Rec protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "15063128",
        "class_list": "",
        "function": "Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051028 mRNA transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P61578-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15042-1",
        "uniprot_id": [
            {
                "id": "RB3GP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15042",
                "type": "external"
            }
        ],
        "mass": 110524.0,
        "length": 981,
        "protein_name": "Rab3 GTPase-activating protein catalytic subunit",
        "gene_name": "RAB3GAP1",
        "organism": "Human",
        "refseq_name": "rab3 GTPase-activating protein catalytic subunit isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001165906",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165906",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAB3GAP1; KIAA0066; RAB3GAP",
        "gene_names_refseq": "MARTS2; P130; RAB3GAP130; RAB3GAP1; RAB3GAP; WARBM1",
        "protein_names_uniprotkb": "Rab3 GTPase-activating protein catalytic subunit; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP",
        "protein_names_refseq": "RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; rab3 GTPase-activating protein catalytic subunit isoform 1; rab3-GAP p130",
        "tax_id": 9606,
        "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 1 (Disease Ontology:DOID:0110716); Martsolf syndrome 2 (MONDO:MONDO:0030376)",
        "pathway": " (hsa:22930);  (R-HSA-6811436);  (R-HSA-8876198)",
        "pathway_count": 3,
        "publication_count": 312,
        "publication_id_list": "10359595;10559986;10562278;10818110;10859313;10990452;11038176;11080672;11179213;11237011;11483508;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12401177;12427552;12432908;12447383;12475894;12684051;12925777;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15483056;15528189;15561770;15692570;15696165;15878329;15914536;15958533;16207721;16314391;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17081983;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;17827179;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18641641;18664496;18669648;18701652;18767875;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19635840;19651622;19656848;19725050;19729655;19745841;19753100;20008558;20068231;20154091;20159109;20159556;20166139;20305638;20308558;20404108;20420828;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21173190;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22130221;22171327;22337587;22365832;22433857;22511774;22562055;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22898188;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23301498;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23481700;23645161;23678941;23684622;23713133;23783758;23839779;24275569;24296415;24644286;24694596;24714562;24715725;24719330;24891604;24917561;24967941;25074980;25233431;25341920;25343031;25418920;25453831;25472813;25576301;25648148;25713415;25892735;25925668;26055712;26063829;26154972;26177209;26245486;26434594;26538022;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27600516;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29314611;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29789417;30315122;30410026;30429286;30484775;30524438;30730599;30779550;30833945;31020640;31154438;31530632;31844290;31848261;31937595;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33141586;33298915;33306828;33537174;33592498;33633747;33691108;33717175;33910511;33912179;33936100;33968037;33981976;34087483;34169395;34171305;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35251023;35318648;35580925;36010968;36215666;36241641;36284347;37186309;37938771;38665916;39534244;39779760;40307207;40914422;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9050864;9136770;9323142;9590177;9671731;9733780;9852129",
        "class_list": "",
        "function": "Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins (PubMed:9030515, PubMed:10859313, PubMed:39779760). Has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43 (PubMed:10859313, PubMed:9030515, PubMed:39779760). Additionally, it has guanine nucleotide exchange factor (GEF) activity towards RAB18, promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604, PubMed:39779760). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and is involved in regulating non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Exome sequencing identifies a novel pathogenic variant in RAB3GAP1 causing Warburg Micro syndrome in a Pakistani family., [RefSeq, PubMed]; Novel manifestations of Warburg micro syndrome type 1 caused by a new splicing variant of RAB3GAP1: a case report. Publication Status: Online-Only, [RefSeq, PubMed]; Proteasomal degradation of p130 facilitate cell cycle deregulation and impairment of cellular differentiation in high-risk Human Papillomavirus 16 and 18 E7 transfected cells., [RefSeq, PubMed]; This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]., [RefSeq]; [Analysis of a case of Warburg micro syndrome type 1 due to variant of RAB3GAP1 gene]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8Z3;C9J837;Q659F5;Q8TBB4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0060079 excitatory postsynaptic potential;GO:0007420 brain development;GO:0060325 face morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 31.8,
        "record_id": "Q15042-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q59GN2-1",
        "uniprot_id": [
            {
                "id": "R39L5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q59GN2",
                "type": "external"
            }
        ],
        "mass": 6323.0,
        "length": 51,
        "protein_name": "Putative ribosomal protein eL39-like 5",
        "gene_name": "RPL39P5",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "RPL39P5",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative ribosomal protein eL39-like 5; 60S ribosomal protein L39 pseudogene 5; Putative 60S ribosomal protein L39-like 5",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "26154972;29557506;29632711;30429286;32502341;33392160;34019948",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit",
        "go_biological_process": "GO:0002181 cytoplasmic translation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q59GN2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5RL73-1",
        "uniprot_id": [
            {
                "id": "RBM48_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5RL73",
                "type": "external"
            }
        ],
        "mass": 41808.0,
        "length": 367,
        "protein_name": "RNA-binding protein 48",
        "gene_name": "RBM48",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 48 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_115496",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115496",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM48; C7orf64; HSPC304",
        "gene_names_refseq": "C7orf64; HSPC304; RBM48",
        "protein_names_uniprotkb": "RNA-binding protein 48",
        "protein_names_refseq": "RNA-binding protein 48 isoform 1; RNA-binding protein 48; UPF0712 protein C7orf64",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84060)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11230166;11237011;25892735;26154972;28904123;29242379;29393594;29632046;30524438;31844290;32357974;32488085;32938616;33509932;33537174;33912179;35051231;36040194;36215666",
        "class_list": "",
        "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Genetic analysis of human RNA binding motif protein 48 (RBM48) reveals an essential role in U12-type intron splicing., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z2K5;B7ZL51;Q5H9T2;Q8IYW7;Q96NS0;Q9H0V7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex",
        "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q5RL73-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T481-1",
        "uniprot_id": [
            {
                "id": "RBM20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T481",
                "type": "external"
            }
        ],
        "mass": 134258.0,
        "length": 1227,
        "protein_name": "RNA-binding protein 20",
        "gene_name": "RBM20",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 20",
        "refseq_ac": [
            {
                "id": "NP_001127835",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127835",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM20",
        "gene_names_refseq": "RBM20",
        "protein_names_uniprotkb": "RNA-binding protein 20; RNA-binding motif protein 20",
        "protein_names_refseq": "RNA-binding protein 20; probable RNA-binding protein 20",
        "tax_id": 9606,
        "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); dilated cardiomyopathy 1DD (Disease Ontology:DOID:0110447); dilated cardiomyopathy (Disease Ontology:DOID:12930)",
        "pathway": " (hsa:282996)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "19712804;19712805;20590677;21846512;22004663;22466703;23186163;23301498;23481700;23861363;23886709;24960161;25645385;26604136;27496873;27531932;29895960;30262925;30871348;30871351;30948719;31583969;32840935;32851336;33188278;34021826;34174465;34322310;34732726;35427468;36140694;36198914;37217939;37593875;37905768;38253038",
        "class_list": "",
        "function": "Dilated cardiomyopathy in patients with RBM20 mutations is associated with advanced disease., [RefSeq, PubMed]; I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy., [RefSeq, PubMed]; RBM20 as a dilated cardiomyopathy gene and reveal a mutation hotspot in the RS domain. Individuals in each family revealed distinct heterozygous missense mutations in exon 9 of RBM20, encoding ribonucleic acid (RNA) binding motif protein 20., [RefSeq, PubMed]; RBM20 missense mutation is a novel gene underlying one form of dilated cardiomyopathy, [RefSeq, PubMed]; RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants., [RefSeq, PubMed]; SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that binds RNA and regulates splicing. Mutations in this gene have been associated with familial dilated cardiomyopathy. [provided by RefSeq, Apr 2014]., [RefSeq]; [Research progress on the expression of the RBM20 gene in dilated cardiomyopathy]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIP5;B5A868;Q5JVI1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:1990935 splicing factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0036464 cytoplasmic ribonucleoprotein granule",
        "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0043484 regulation of RNA splicing;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0060914 heart formation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q5T481-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6MZT1-1",
        "uniprot_id": [
            {
                "id": "R7BP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6MZT1",
                "type": "external"
            }
        ],
        "mass": 28962.0,
        "length": 257,
        "protein_name": "Regulator of G protein signaling 7-binding protein",
        "gene_name": "RGS7BP",
        "organism": "Human",
        "refseq_name": "regulator of G-protein signaling 7-binding protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001025046",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025046",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RGS7BP; R7BP",
        "gene_names_refseq": "R7BP; RGS7BP",
        "protein_names_uniprotkb": "Regulator of G protein signaling 7-binding protein; R7 family-binding protein",
        "protein_names_refseq": "R7 family-binding protein; regulator of G-protein signaling 7-binding protein isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:401190)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "16867977;19497306;21457877;26895961;28432124;30379171;30540250",
        "class_list": "",
        "function": "BL3-ht2 of RGS7BP may be an important genetic variant associated with AERD. The haplotype of block 3 may play a protective role against aspirin hypersensitivity in asthma, perhaps by altering the responsiveness of muscarinic receptors., [RefSeq, PubMed]; Cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP., [RefSeq, PubMed]; Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13), [RefSeq, PubMed]; Data mapped differences in deuterium exchange between the regulator of G protein signaling 7 (RGS7)-Gbeta5 protein(Gbeta5)-RGS7 family binding protein (R7BP) trimer and the RGS7-Gbeta5 dimer. Publication Status: Online-Only, [RefSeq, PubMed]; R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7., [RefSeq, PubMed]; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation., [UniProtKB, UniProtKB]; The successful purification of functionally intact Gbeta5-free recombinant RGS11 was reported that differentially interact with R7BP and Galpha(oa)., [RefSeq, PubMed]; This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z3X1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0043198 dendritic shaft",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0060078 regulation of postsynaptic membrane potential",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q6MZT1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NVV1-1",
        "uniprot_id": [
            {
                "id": "R13P3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NVV1",
                "type": "external"
            }
        ],
        "mass": 12135.0,
        "length": 102,
        "protein_name": "Putative ribosomal protein uL13-like",
        "gene_name": "RPL13AP3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "RPL13AP3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative ribosomal protein uL13-like; 60S ribosomal protein L13a pseudogene 3; Putative 60S ribosomal protein L13a protein RPL13AP3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "26154972;29557506;31844290;33392160;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q6NVV1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZMN7-1",
        "uniprot_id": [
            {
                "id": "PZRN4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZMN7",
                "type": "external"
            }
        ],
        "mass": 117103.0,
        "length": 1036,
        "protein_name": "PDZ domain-containing RING finger protein 4",
        "gene_name": "PDZRN4",
        "organism": "Human",
        "refseq_name": "PDZ domain-containing RING finger protein 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001158067",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158067",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDZRN4; LNX4; SEMCAP3L",
        "gene_names_refseq": "LNX4; PDZRN4; SAMCAP3L",
        "protein_names_uniprotkb": "PDZ domain-containing RING finger protein 4; Ligand of Numb protein X 4; SEMACAP3-like protein",
        "protein_names_refseq": "IMAGE5767589; PDZ domain-containing RING finger protein 4 isoform 1; PDZ domain-containing RING finger protein 4; SEMACAP3-like protein; ligand of Numb protein X 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29951)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11230166;11237011;15010864;16959974;20944657;26486104;29557506;30429286;31154438;34087483;35051231;35494241",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results showed that PDZRN4 might be a potential tumour suppressor gene and had anti-proliferative effect on hepatocellular carcinoma cell proliferation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 61,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LY3;Q52LY4;Q6N052;Q8IUU1;Q9NTP7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q6ZMN7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZS82-1",
        "uniprot_id": [
            {
                "id": "R9BP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZS82",
                "type": "external"
            }
        ],
        "mass": 25148.0,
        "length": 235,
        "protein_name": "Regulator of G protein signaling 9-binding protein",
        "gene_name": "RGS9BP",
        "organism": "Human",
        "refseq_name": "regulator of G-protein signaling 9-binding protein",
        "refseq_ac": [
            {
                "id": "NP_997274",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997274",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RGS9BP; R9AP",
        "gene_names_refseq": "R9AP; RGS9BP",
        "protein_names_uniprotkb": "Regulator of G protein signaling 9-binding protein; RGS9-anchoring protein",
        "protein_names_refseq": "RGS9 anchor protein; RGS9-anchoring protein; regulator of G-protein signaling 9-binding protein",
        "tax_id": 9606,
        "disease": "bradyopsia 2 (Disease Ontology:DOID:0070364)",
        "pathway": " (hsa:388531);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10037746;10051575;10564809;10676965;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12499365;12825937;1356371;1379636;1387789;1436039;14702087;15946941;16274222;16895762;16908407;17114291;17636946;17698770;18318613;18803695;19818506;19948975;1999465;20430952;20975703;22658984;2540796;2550422;2558719;3006923;3164688;31844290;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9430683;9459445;9506952",
        "class_list": "",
        "function": "As the light level is increased and the PDE6* concentration in the normal rises relative to that in the observer lacking RGS9-1, the temporal advantage of the latter is soon lost, leaving only the deficit due to delayed deactivation. Publication Status: Online-Only, [RefSeq, PubMed]; Five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones, [RefSeq, PubMed]; Homozygous mutations in R9AP gene that encodes the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identifird in patients with bradyopsia., [RefSeq, PubMed]; Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator), [RefSeq, PubMed]; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity)., [UniProtKB]; The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010]., [RefSeq]; This is the first report describing a nonsense mutation in RGS9., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZVJ6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0043005 neuron projection;GO:0001750 photoreceptor outer segment",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0050908 detection of light stimulus involved in visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q6ZS82-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z6E9-1",
        "uniprot_id": [
            {
                "id": "RBBP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z6E9",
                "type": "external"
            }
        ],
        "mass": 201564.0,
        "length": 1792,
        "protein_name": "E3 ubiquitin-protein ligase RBBP6",
        "gene_name": "RBBP6",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RBBP6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_008841",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008841",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBBP6; My038; P2PR; PACT; RBQ1",
        "gene_names_refseq": "MY038; P2P-R; PACT; RBBP6; RBQ-1; SNAMA",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RBBP6; 2.3.2.27; Proliferation potential-related protein; Protein P2P-R; RBQ-1; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding Q protein 1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RBBP6 isoform 1; E3 ubiquitin-protein ligase RBBP6; RB-binding Q-protein 1; RING-type E3 ubiquitin transferase RBBP6; p53-associated cellular protein of testis; proliferation potential-related protein; protein P2P-R; retinoblastoma binding protein 6; retinoblastoma-binding Q protein 1",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:5930);  (R-HSA-9013422);  (R-HSA-9770562);  (R-HSA-983168)",
        "pathway_count": 4,
        "publication_count": 166,
        "publication_id_list": "10.1101/2023.09.13.557529;10669729;11060040;11062501;11237011;11350924;12064457;12646216;14734113;14749727;15037765;15224091;15224092;15302935;15475430;15565158;15571818;16396680;16595681;16849449;16954532;16964243;17081983;17128255;17322306;17470788;17525332;17924679;18212344;18220336;18288197;18318008;18452278;18662542;18669648;18767875;18835386;18851979;19007248;19028597;19217410;19352404;19413330;19452197;19489725;19651622;19664995;19690332;19851334;19874575;19940261;20068231;20695905;20873783;21295486;21406692;22130672;2261476;22813749;23186163;23301498;23481700;23874216;24076191;24149845;24275569;24608665;24715725;24726359;25301780;25301781;25576301;25755297;25880248;25892735;26154972;26375851;27314390;27600516;27846572;27862975;27920218;28096519;28218747;28228285;28514659;28657654;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29351928;29393594;29437277;29493099;29508533;29557506;29632711;30139799;30257008;30315122;30379171;30410026;30550789;30779550;30896450;31154438;31217245;31222486;31431478;31844290;31848261;31871319;31998317;32119511;32157095;32161166;32350084;32357974;32488085;32502341;32816001;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33683013;33691108;33717175;33968037;33981976;34019948;34087483;34171305;34211107;34405274;34561969;34932366;35051231;35138101;35177536;35251023;35254053;35580925;36010968;36241641;36284347;37217939;37322627;37938771;38253038;38665916;39531497;39534244;40596516;8595913;9380723;9659921;9668046",
        "class_list": "",
        "function": "(Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription., [UniProtKB, PubMed]; Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359)., [UniProtKB, PubMed, UniProtKB, PubMed]; RBBP6 activates the pre-mRNA 3' end processing machinery in humans., [RefSeq, PubMed]; The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway., [RefSeq, PubMed]; The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 11,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 11,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 61,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 77,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q147T5;Q15290;Q6DKH4;Q6P4C2;Q6YNC9;Q7Z6E8;Q8N0V2;Q96PH3;Q9H3I8;Q9H5M5;Q9NPX4",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.1.4.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "2.7.7.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.7.7.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.7.1.78",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.7.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006275 regulation of DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 18.5,
        "record_id": "Q7Z6E9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NC74-1",
        "uniprot_id": [
            {
                "id": "RB8NL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NC74",
                "type": "external"
            }
        ],
        "mass": 71432.0,
        "length": 664,
        "protein_name": "RBBP8 N-terminal-like protein",
        "gene_name": "RBBP8NL",
        "organism": "Human",
        "refseq_name": "RBBP8 N-terminal-like protein",
        "refseq_ac": [
            {
                "id": "NP_543023",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543023",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBBP8NL; C20orf151",
        "gene_names_refseq": "C20orf151; RBBP8NL",
        "protein_names_uniprotkb": "RBBP8 N-terminal-like protein",
        "protein_names_refseq": "RBBP8 N-terminal-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140893)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "29557506;32387766;33298915;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RP98;Q8N4Z9;Q9BR75;Q9H0Y9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8NC74-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96IS3-1",
        "uniprot_id": [
            {
                "id": "RAX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96IS3",
                "type": "external"
            }
        ],
        "mass": 20086.0,
        "length": 184,
        "protein_name": "Retina and anterior neural fold homeobox protein 2",
        "gene_name": "RAX2",
        "organism": "Human",
        "refseq_name": "retina and anterior neural fold homeobox protein 2",
        "refseq_ac": [
            {
                "id": "NP_116142",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116142",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAX2; QRX; RAXL1",
        "gene_names_refseq": "ARMD6; CORD11; QRX; RAX2; RAXL1; RP95",
        "protein_names_uniprotkb": "Retina and anterior neural fold homeobox protein 2; Q50-type retinal homeobox protein; Retina and anterior neural fold homeobox-like protein 1",
        "protein_names_refseq": "Q50-type retinal homeobox protein; retina and anterior neural fold homeobox like 1; retina and anterior neural fold homeobox protein 2; retina and anterior neural fold homeobox-like protein 1",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 95 (Disease Ontology:DOID:0061112); age related macular degeneration 6 (Disease Ontology:DOID:0110018); cone-rod dystrophy 11 (Disease Ontology:DOID:0111018)",
        "pathway": " (hsa:84839)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "15028672;20237496;25789692;30377383",
        "class_list": "",
        "function": "A frameshift heterozygous mutation in RAX2 inherited in an autosomal dominant fashion was associated with mixed cone and rod dysfunction., [RefSeq, PubMed]; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a homeodomain-containing protein that plays a role in eye development. Mutation of this gene causes age-related macular degeneration type 6, an eye disorder resulting in accumulations of protein and lipid beneath the retinal pigment epithelium and within the Bruch's membrane. Defects in this gene can also cause cone-rod dystrophy type 11, a disease characterized by the initial degeneration of cone photoreceptor cells and resulting in loss of color vision and visual acuity, followed by the degeneration of rod photoreceptor cells, which progresses to night blindness and the loss of peripheral vision. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q96IS3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H082-1",
        "uniprot_id": [
            {
                "id": "RB33B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H082",
                "type": "external"
            }
        ],
        "mass": 25718.0,
        "length": 229,
        "protein_name": "Ras-related protein Rab-33B",
        "gene_name": "RAB33B",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-33B",
        "refseq_ac": [
            {
                "id": "NP_112586",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112586",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAB33B",
        "gene_names_refseq": "RAB33B",
        "protein_names_uniprotkb": "Ras-related protein Rab-33B; 3.6.5.2",
        "protein_names_refseq": "ras-related protein Rab-33B",
        "tax_id": 9606,
        "disease": "Smith-McCort dysplasia 2 (Disease Ontology:DOID:0081271)",
        "pathway": " (hsa:83452);  (R-HSA-6811438);  (R-HSA-8854214);  (R-HSA-8873719)",
        "pathway_count": 4,
        "publication_count": 107,
        "publication_id_list": "10189370;10202141;10652308;10652516;11141079;11230166;11237011;11389151;11447212;11675392;11718716;11748249;12011112;12383348;12429822;15504911;15718469;15728195;15758030;16055087;16395330;16401880;1648736;17114793;17274799;17411337;17658474;17901050;18086915;18199687;18256213;18319245;18448665;18451304;18466115;18532927;19164740;19536132;19603039;19715559;20095038;20116244;20163571;20363736;20404108;20874812;21383079;21458671;21807881;21808068;22013193;22188167;22219378;22613832;22652534;22694141;22762500;22795129;22854040;23019362;23042644;23091056;23239882;23378023;23462996;23481700;23562278;23839779;23936529;23940353;24023390;24119662;25341920;25708460;26154972;26969162;29557506;30315122;31637018;31844290;31848261;32350084;32938616;32960676;33912179;34000439;34284742;35154160;35580925;40596516;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8636227;8662963;8836150;8945478;9244307;9476900;9510256;9653114;9707577;9915833",
        "class_list": "",
        "function": "A second autosomal recessive locus for Dyggve-Melchior-Clausen syndrome exists on 4q31.1 and that Rab protein-encoding gene, RAB33B, is the likely disease gene in that locus., [RefSeq, PubMed]; RAB33B and PCNT variants in two Pakistani families with skeletal dysplasia and short stature. Publication Status: Online-Only, [RefSeq, PubMed]; Rab33 modulates autophagosome formation through interaction with Atg16L, [RefSeq, PubMed]; Seven patients with Smith-McCort dysplasia 2: Four novel nonsense variants in RAB33B and follow-up findings., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20163571, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18448665, PubMed:20163571, PubMed:21808068). RAB33B acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (PubMed:20163571). Participates in autophagosome formation by recruiting the ATG12-ATG5-ATG16L1 complex to phagophores, probably in a nucleotide-independent manner (PubMed:18448665, PubMed:32960676)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R987;Q4W5B0",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.113",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.113",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.114",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0034045 phagophore assembly site membrane",
        "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0034497 protein localization to phagophore assembly site;GO:0048705 skeletal system morphogenesis;GO:0034067 protein localization to Golgi apparatus",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "Q9H082-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08922-1",
        "uniprot_id": [
            {
                "id": "ROS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08922",
                "type": "external"
            }
        ],
        "mass": 263915.0,
        "length": 2347,
        "protein_name": "Proto-oncogene tyrosine-protein kinase ROS",
        "gene_name": "ROS1",
        "organism": "Human",
        "refseq_name": "proto-oncogene tyrosine-protein kinase ROS isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002935",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002935",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ROS1; MCF3; ROS",
        "gene_names_refseq": "MCF3; ROS1; ROS; c-ros-1",
        "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase ROS; 2.7.10.1; Proto-oncogene c-Ros-1; Proto-oncogene c-Ros; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase",
        "protein_names_refseq": "ROS proto-oncogene 1, receptor tyrosine kinase; c-ros oncogene 1, receptor tyrosine kinase; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS isoform 1 precursor; proto-oncogene tyrosine-protein kinase ROS; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6098)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "11094073;11237011;11266449;12538861;12661006;16885344;17344846;17416557;23292247;2352949;25418920;25688157;25892735;26758079;27543614;28228285;28759046;29237092;29331515;29557506;3023956;31575892;31844290;32157095;32387766;32488085;32938616;32983136;33592498;33936100;35051231;35494241;36010968;36215666;37579577;37587872;3785223;37856763;38148635;38468443;8143271",
        "class_list": "",
        "function": "CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells., [RefSeq, PubMed]; Clinicopathologic and molecular characteristics of small-scale ROS1-mutant non-small cell lung cancer (NSCLC) patients., [RefSeq, PubMed]; Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors., [RefSeq, PubMed]; Inflammatory Myofibroblastic Tumor With ROS1 Gene Fusions in Children and Young Adolescents., [RefSeq, PubMed]; RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells., [RefSeq, PubMed]; Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2., [UniProtKB, PubMed, PubMed, UniProtKB]; This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 31,
        "predicted_n_glycosites": 30,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 283,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 34,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15368;Q5TDB5",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001558 regulation of cell growth",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "P08922-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P60059-1",
        "uniprot_id": [
            {
                "id": "SC61G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P60059",
                "type": "external"
            }
        ],
        "mass": 7741.0,
        "length": 68,
        "protein_name": "Protein transport protein Sec61 subunit gamma",
        "gene_name": "SEC61G",
        "organism": "Human",
        "refseq_name": "protein transport protein Sec61 subunit gamma",
        "refseq_ac": [
            {
                "id": "NP_001012474",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012474",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEC61G",
        "gene_names_refseq": "SEC61G; SSS1",
        "protein_names_uniprotkb": "Protein transport protein Sec61 subunit gamma",
        "protein_names_refseq": "SEC61 translocon gamma subunit; Sec61 gamma subunit; protein transport protein SEC61 gamma subunit; protein transport protein Sec61 subunit gamma",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:23480);  (R-HSA-1236974);  (R-HSA-1799339);  (R-HSA-9609523)",
        "pathway_count": 4,
        "publication_count": 94,
        "publication_id_list": "11964406;12853463;15708368;16469117;16777091;17382883;18166647;18455985;18477612;18692471;19217269;20375064;20444697;20676083;21444755;21466504;21636303;21654843;21743475;22153078;22223895;23041287;23129660;23142665;23186163;23246001;23533635;23613522;24392163;25083866;25179605;25415308;25502872;25535373;25576301;25713138;26154972;26675233;26992070;27193484;27226539;27458190;27600516;27862975;27920218;28104892;28218747;28228285;28832583;28834231;28904123;29242231;29242379;29393594;29493099;29557506;30315122;30429286;30550790;30779550;31154438;31217245;31530632;31844290;32157095;32265295;32350084;32820719;32938616;33298915;33592498;33691108;33912179;33936100;33968037;34019948;34211107;34357683;34561969;34590792;34774014;35051231;35154160;35251023;35580925;36010968;36092956;36241641;36261522;36284347;36697828;38421527;39894887;9631292",
        "class_list": "",
        "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis., [RefSeq, PubMed]; Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation. Publication Status: Online-Only, [RefSeq, PubMed]; SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma., [RefSeq, PubMed]; The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4J0;P38384;Q6IB25",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005784 Sec61 translocon complex;GO:0071261 Ssh1 translocon complex",
        "go_biological_process": "GO:0031204 post-translational protein targeting to membrane, translocation;GO:0045047 protein targeting to ER;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "P60059-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYN0-1",
        "uniprot_id": [
            {
                "id": "SRXN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYN0",
                "type": "external"
            }
        ],
        "mass": 14259.0,
        "length": 137,
        "protein_name": "Sulfiredoxin-1",
        "gene_name": "SRXN1",
        "organism": "Human",
        "refseq_name": "sulfiredoxin-1",
        "refseq_ac": [
            {
                "id": "NP_542763",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542763",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SRXN1; C20orf139; SRX1; SRX",
        "gene_names_refseq": "C20orf139; Npn3; SRX1; SRXN1; SRX",
        "protein_names_uniprotkb": "Sulfiredoxin-1; 1.8.98.2",
        "protein_names_refseq": "sulfiredoxin-1; sulphiredoxin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140809);  (R-HSA-9818027)",
        "pathway_count": 2,
        "publication_count": 121,
        "publication_id_list": "10706635;10733945;10821856;11309284;12234984;12235164;12506115;15448164;15520857;15590625;15728556;15952770;16314513;16565085;16818657;17234762;17942419;19028565;19273602;19608619;20068231;20460467;21209280;21775727;22667998;22995213;23027624;23186163;24041992;24129315;24715725;25002527;25576301;25645385;26154972;26768311;26992070;27100828;27543614;27600516;27653015;27756681;27862975;28218747;28228285;28832583;28904123;28985506;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29693710;29786170;29959055;30001391;30192525;30315122;30410026;30429286;30779550;31222486;31597407;31844290;31848261;31937595;31998317;32157095;32265295;32284348;32357974;32387766;32488085;32502341;32601262;32897882;32938616;32955798;32983136;33043019;33043033;33123756;33141586;33298915;33392160;33462411;33537174;33592498;33691108;33717175;33774477;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37017121;37726767;37938771;38852489;39029574;7959763;9240432",
        "class_list": "",
        "function": "Actin and protein tyrosine phosphatase 1B were identified in vitro as targets of sulfiredoxin 1 (Srx1)-dependent deglutathionylation., [RefSeq, PubMed]; Analysis of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin, [RefSeq, PubMed]; Antioxidative stress protein SRXN1 can be used as a radiotherapy prognostic marker for prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1., [RefSeq, PubMed]; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625)., [UniProtKB, PubMed, PubMed]; Sulfiredoxin-1 is a promising novel prognostic biomarker for hepatocellular carcinoma., [RefSeq, PubMed]; Sulfiredoxin-1 promotes the growth of hepatocellular carcinoma by inhibiting TFEB-mediated autophagy and lysosome biogenesis., [RefSeq, PubMed]; The reduction of the cysteine sulfinic acid moiety within the active site of the peroxiredoxin by sulfiredoxin involves novel sulfur chemistry and the use of ATP and Mg(2+)., [RefSeq, PubMed]; Unraveling the role of sulfiredoxin-1 in early-onset preeclampsia: A key player in trophoblast ferroptosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R543;Q8NDM3;Q96AK6",
        "ec_number_list": [
            {
                "id": "1.11.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24",
                "type": "external"
            },
            {
                "id": "1.8.98.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.98.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0005524 ATP binding;GO:0032542 sulfiredoxin activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034599 cellular response to oxidative stress",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9BYN0-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P25787-1",
        "uniprot_id": [
            {
                "id": "PSA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P25787",
                "type": "external"
            }
        ],
        "mass": 25899.0,
        "length": 234,
        "protein_name": "Proteasome subunit alpha type-2",
        "gene_name": "PSMA2",
        "organism": "Human",
        "refseq_name": "proteasome subunit alpha type-2",
        "refseq_ac": [
            {
                "id": "NP_002778",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002778",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMA2; HC3; PSC3",
        "gene_names_refseq": "HC3; MU; PMSA2; PSC2; PSMA2",
        "protein_names_uniprotkb": "Proteasome subunit alpha type-2; Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3; Proteasome subunit alpha-2; alpha-2",
        "protein_names_refseq": "alpha-2; macropain subunit C3; multicatalytic endopeptidase complex subunit C3; proteasome (prosome, macropain) subunit, alpha type, 2; proteasome component C3; proteasome subunit HC3; proteasome subunit alpha 2; proteasome subunit alpha type-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5683);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-6798695);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9912633);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 70,
        "publication_count": 1067,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11237011;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11521686;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12181345;12186903;12194817;12198130;12234927;12297295;12351678;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;12912907;12915405;12917689;12917691;12923053;12963847;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14564014;14585973;14603323;14611647;14625308;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15244466;15247232;15257295;15282312;15292211;15300262;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592455;15592474;15601839;15611333;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15944226;15983046;15987702;16056267;16061793;16112985;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16548883;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16959974;16962933;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18083107;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18692471;18701449;18711132;18716059;18719096;18720373;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;18926707;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19208626;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19608861;19617556;19622347;19666503;1968359;19684112;19706539;19729658;19734889;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20068231;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;2025653;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21177870;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22265677;22267219;22279049;22286099;22306028;22306998;22318583;2236053;22391301;22422618;22424782;22427670;22440753;22466964;22505454;22508986;22537386;22544926;2261476;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22872865;22885700;22897851;22959436;22964642;22982193;23063411;23069990;23112049;23140627;23144924;23159851;23186163;23201271;23217742;23236459;23256519;23274085;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23481700;23486064;23495936;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23650620;23661552;23685075;23719536;23725801;23746841;23824326;23825189;23851460;23867461;23878308;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24298019;24302888;24309468;24366543;24366607;24367090;24493797;24582806;24585635;24636985;24685677;24714562;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25132172;25133187;25152365;25197364;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25418920;25531226;25547115;25576301;25578727;25578875;25584290;25599644;25654763;2570070;2570460;25733683;25740432;25793262;25892735;25921531;26091038;26117325;26133119;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26375851;26443277;26460955;26583321;26632597;26728094;26778333;26811146;26906416;26929215;26942676;26992070;27030794;27137657;27176742;27222660;27249176;27342858;27428775;27466718;27493187;27565346;27572267;27600516;27846572;27862975;27920218;28063628;28115426;28132103;28178531;28218747;28228285;28263418;28317937;28380357;28442575;28514659;28598414;28832583;28834231;28904123;2898143;29055231;29153394;29233872;29242379;29314611;29331515;29356040;29393594;29437277;29450944;2946959;29493099;29526543;29557506;29632046;29632312;29632711;29717933;29769354;29786170;30118680;30244831;30315122;30334692;30334693;30410026;30429286;30444036;30484775;30524438;30610225;30728908;30779550;31011209;31020640;31217245;3129195;31530632;31546975;31679946;31844290;31998317;32005965;32157095;32161166;32284348;32293500;32350084;32357974;32387766;32488085;32640524;32672401;32897882;32938616;32981041;32983136;33009401;33141586;33298915;33406423;33444648;33592498;33691108;33717175;33791708;33859744;33909987;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34215617;34229054;34315872;34357683;34433824;34509645;3457471;34711951;3472246;34725712;34932366;35051231;35138101;35251023;35318648;35385574;35561310;35580925;36010968;36198437;36215666;36241641;36284347;36581221;36680137;37676773;37938771;38574629;38665916;39894887;40914422;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7628694;7639698;7799959;7809113;7811265;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8107774;8140422;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8610016;8626374;8662591;8662795;8670417;8689684;8692836;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9380723;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; HLA-A, HSPA5, IGFBP5 and PSMA2 Are Restriction Factors for Zika Virus Growth in Astrocytic Cells. Publication Status: Online-Only, [RefSeq, PubMed]; PSMA2 promotes glioma proliferation and migration via EMT., [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ICS6;Q9BU45",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045061 thymic T cell selection;GO:0045063 T-helper 1 cell differentiation;GO:0071357 cellular response to type I interferon;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 107.0,
        "record_id": "P25787-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P2D0-1",
        "uniprot_id": [
            {
                "id": "ZFP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P2D0",
                "type": "external"
            }
        ],
        "mass": 47516.0,
        "length": 407,
        "protein_name": "Zinc finger protein 1 homolog",
        "gene_name": "ZFP1",
        "organism": "Human",
        "refseq_name": "zinc finger protein 1 homolog isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001305398",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305398",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZFP1; ZNF475",
        "gene_names_refseq": "PITA; ZFP1; ZNF475",
        "protein_names_uniprotkb": "Zinc finger protein 1 homolog; Zfp-1; Zinc finger protein 475",
        "protein_names_refseq": "p53 inhibitor of TIGAR activation; zinc finger protein 1 homolog isoform 1; zinc finger protein 1 homolog; zinc finger protein 475",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:162239);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 29,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;19844255;2163759;25218447;25755297;25772364;27600516;29557506;31844290;32157095;32357974;32938616;33717175;33912179;35580925;37938771;39261568;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]; ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5Q7;B4DKG9;Q8N188;Q8N9F9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q6P2D0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZ09-1",
        "uniprot_id": [
            {
                "id": "UBAP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZ09",
                "type": "external"
            }
        ],
        "mass": 55084.0,
        "length": 502,
        "protein_name": "Ubiquitin-associated protein 1",
        "gene_name": "UBAP1",
        "organism": "Human",
        "refseq_name": "ubiquitin-associated protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001164672",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164672",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBAP1; NAG20",
        "gene_names_refseq": "NAG20; SPG80; UAP; UBAP-1; UBAP1; UBAP",
        "protein_names_uniprotkb": "Ubiquitin-associated protein 1; Nasopharyngeal carcinoma-associated gene 20 protein; UBAP-1",
        "protein_names_refseq": "nasopharyngeal carcinoma-associated gene 20 protein; ubiquitin-associated protein 1 isoform 2",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 80 (Disease Ontology:DOID:0112341)",
        "pathway": " (hsa:51271);  (R-HSA-162588);  (R-HSA-174490);  (R-HSA-917729);  (R-HSA-9610379);  (R-HSA-9615710)",
        "pathway_count": 6,
        "publication_count": 72,
        "publication_id_list": "11112487;11230166;11237011;11527981;11563910;11599797;12451983;12663786;14624836;15075231;15218037;15473846;15509564;15613341;16371348;16775314;16973552;18452278;19527882;19640981;19651622;20068231;21238931;21289126;21757351;2204156;22405001;22762019;23186163;23266279;23301498;23305486;24275569;24284069;25576301;25645385;25961502;27839950;27846572;2799391;28832583;29242379;29557506;29632711;30929741;31154438;31203368;31373491;31530632;31696996;31844290;31848261;32157095;32350084;32488085;32502341;32897882;32934340;32938616;32983136;33141586;33298915;33592498;33936100;33968037;34087483;34191852;35051231;35347897;36241641;9506952;9525617",
        "class_list": "",
        "function": "A novel UBAP1 truncated variant in a Chinese family with hereditary spastic paraplegia., [RefSeq, PubMed]; Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2., [UniProtKB, UniProtKB]; Identification of UBAP1 mutations in juvenile hereditary spastic paraplegia in the 100,000 Genomes Project., [RefSeq, PubMed]; The identification of differential expression patterns of ubap1 in different tumors., [RefSeq, PubMed]; This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]., [RefSeq]; Truncating variants in UBAP1 associated with childhood-onset nonsyndromic hereditary spastic paraplegia., [RefSeq, PubMed]; Two novel truncating variants in UBAP1 are responsible for hereditary spastic paraplegia. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z348;B7Z8N9;D3DRL7;F5GXE2;F5H0J8;Q4V759;Q53FP7;Q5T7B3;Q6FI75;Q8NC52;Q8NCG6;Q8NCH9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0000813 ESCRT I complex",
        "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0090148 membrane fission;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9NZ09-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5U651-1",
        "uniprot_id": [
            {
                "id": "RAIN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5U651",
                "type": "external"
            }
        ],
        "mass": 103457.0,
        "length": 963,
        "protein_name": "Ras-interacting protein 1",
        "gene_name": "RASIP1",
        "organism": "Human",
        "refseq_name": "ras-interacting protein 1",
        "refseq_ac": [
            {
                "id": "NP_060275",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060275",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RASIP1",
        "gene_names_refseq": "RAIN; RASIP1",
        "protein_names_uniprotkb": "Ras-interacting protein 1; Rain",
        "protein_names_refseq": "ras-interacting protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54922)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11237011;15031288;20166139;21060863;22354037;24275569;25576301;26780829;26992070;27839947;27862975;29557506;29786170;30429286;31624086;31844290;32157095;32488085;32897882;32938616;33141586;35051231;35580925;36215666;36241641;36967521;37938771;38253038",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[PLoS Genet. 2010;6(11). doi: 10.1371/annotation/841bfadf-85d1-4059-894f-2863d73fa963. Xueling, Sim [corrected to Sim, Xueling]] Publication Status: Online-Only, [RefSeq, PubMed]; RAIN Is a Novel Enhancer-Associated lncRNA That Controls RUNX2 Expression and Promotes Breast and Thyroid Cancer., [RefSeq, PubMed]; Rain is a novel protein that can serve as an effector of endomembrane-localized Ras, [RefSeq, PubMed]; Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells., [RefSeq, PubMed]; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy., [UniProtKB, PubMed, PubMed]; Results show that Rasip1 RA domain formed a dimer that can bind two Rap1 or Ras molecules and solved the Rap1-RRA complex and found that Rasip1 binds Rap1 in the Switch I region, and Rap1 binding induces few conformation changes to Rasip1 stabilizing a beta strand and an unstructured loop., [RefSeq, PubMed]; These studies establish that the binding of HEG1 to Rasip1 mediates Rap1-dependent recruitment of Rasip1 to and stabilization of endothelial cell cell-cell junctions. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6U676",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051020 GTPase binding",
        "go_cellular_component": "GO:0005911 cell-cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0005795 Golgi stack;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007165 signal transduction;GO:0043087 regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q5U651-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31151-1",
        "uniprot_id": [
            {
                "id": "S10A7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31151",
                "type": "external"
            }
        ],
        "mass": 11471.0,
        "length": 101,
        "protein_name": "Protein S100-A7",
        "gene_name": "S100A7",
        "organism": "Human",
        "refseq_name": "protein S100-A7",
        "refseq_ac": [
            {
                "id": "NP_002954",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002954",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S100A7; PSOR1; S100A7C",
        "gene_names_refseq": "PSOR1; S100A7c; S100A7",
        "protein_names_uniprotkb": "Protein S100-A7; Psoriasin; S100 calcium-binding protein A7",
        "protein_names_refseq": "protein S100-A7; psoriasin 1",
        "tax_id": 9606,
        "disease": "psoriasis (Disease Ontology:DOID:8893)",
        "pathway": " (hsa:6278);  (R-HSA-6798695);  (R-HSA-6799990)",
        "pathway_count": 3,
        "publication_count": 46,
        "publication_id_list": "10026247;12421467;12664160;1286667;15299793;1940442;19810752;20305658;22747601;23276281;23431180;23481700;23650620;24715725;24842328;25597447;26374642;26375851;26992070;28218747;28467828;29314611;29393594;29437277;30833945;31222486;32387766;32983136;34078123;34171305;34932366;35051231;35154160;35580925;36010968;37938771;38217031;38473906;38499391;38665916;38750317;38892279;8526920;8618345;8692836;9562557",
        "class_list": "",
        "function": "Correlation between S100A7 and immune characteristics, methylation, tumor stemness and tumor heterogeneity in pan-cancer and its role in chemotherapy resistance in breast cancer., [RefSeq, PubMed]; Deciphering the significance of anoikis in bladder cancer and systematic analysis of S100A7 as a potential therapeutic target. Publication Status: Online-Only, [RefSeq, PubMed]; GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples. Publication Status: Online-Only, [RefSeq, PubMed]; Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The antimicrobial peptide psoriasin has immunoregulatory activities and is involved in skin innate immunity., [RefSeq, PubMed]; The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]., [RefSeq]; Upregulation of psoriasin/S100A7 correlates with clinical severity in patients with oral lichen planus. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SY67;Q6FGE3;Q9H1E2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0140486 zinc ion sequestering activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0010820 positive regulation of T cell chemotaxis;GO:0032496 response to lipopolysaccharide;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070374 positive regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "P31151-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULK5-1",
        "uniprot_id": [
            {
                "id": "VANG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULK5",
                "type": "external"
            }
        ],
        "mass": 59714.0,
        "length": 521,
        "protein_name": "Vang-like protein 2",
        "gene_name": "VANGL2",
        "organism": "Human",
        "refseq_name": "vang-like protein 2",
        "refseq_ac": [
            {
                "id": "NP_065068",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065068",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VANGL2; KIAA1215; STB1",
        "gene_names_refseq": "LPP1; LTAP; STB1; STBM1; STBM; VANGL2",
        "protein_names_uniprotkb": "Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2",
        "protein_names_refseq": "loop-tail protein 1 homolog; loop-tail-associated protein; strabismus 1; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila); vang-like protein 2",
        "tax_id": 9606,
        "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074); neural tube defects, susceptibility to (MONDO:MONDO:0020705)",
        "pathway": " (hsa:57216);  (R-HSA-4086400);  (R-HSA-4608870);  (R-HSA-9696264);  (R-HSA-9696270);  (R-HSA-9696273)",
        "pathway_count": 6,
        "publication_count": 94,
        "publication_id_list": "10664463;10698942;10862746;11101902;11237011;11358862;11751577;11779461;11784792;11940653;12015986;12134165;12244061;12533515;12724779;12839624;12842009;14636582;14732713;15143170;15169958;15501440;15608632;15738000;15936275;15937478;16116452;16280981;16481321;16495441;16602827;16687519;16723543;16971168;17021034;17081983;17130287;17373907;17433286;17627283;18034999;18162551;18215320;18256687;18719708;18798527;18996843;19103606;19136556;19365405;19379695;19523939;19530173;19589360;20004982;20006983;20558380;20803696;20811643;20940229;21316585;21983142;22773843;23109420;23140627;23140633;23144463;23396967;23535009;23821037;24690281;25627785;25888806;26969432;28834231;29063958;29242379;29786170;31871319;32157095;32350084;32502341;33592498;33936100;35251023;36010968;37815931;38669183;39064873;39269442;8649376;9531558;9674432;9716412",
        "class_list": "",
        "function": "Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations., [RefSeq, PubMed]; Expression Profiles of ITGA8 and VANGL2 Are Altered in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). Publication Status: Online-Only, [RefSeq, PubMed]; Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish., [RefSeq, PubMed]; Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity)., [UniProtKB, UniProtKB]; Results suggest that there is no specific mutation responsible for the Tetralogy of Fallot phenotype in the Vangl2 gene [Vangl2]., [RefSeq, PubMed]; The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]., [RefSeq]; Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DVE9;Q5T212",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle",
        "go_biological_process": "GO:0001843 neural tube closure;GO:0060071 Wnt signaling pathway, planar cell polarity pathway;GO:0001947 heart looping;GO:1905515 non-motile cilium assembly;GO:0035787 cell migration involved in kidney development",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q9ULK5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11086-1",
        "uniprot_id": [
            {
                "id": "PNMT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11086",
                "type": "external"
            }
        ],
        "mass": 30855.0,
        "length": 282,
        "protein_name": "Phenylethanolamine N-methyltransferase",
        "gene_name": "PNMT",
        "organism": "Human",
        "refseq_name": "phenylethanolamine N-methyltransferase",
        "refseq_ac": [
            {
                "id": "NP_002677",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002677",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PNMT; PENT",
        "gene_names_refseq": "PENT; PNMTase; PNMT",
        "protein_names_uniprotkb": "Phenylethanolamine N-methyltransferase; 2.1.1.28; Noradrenaline N-methyltransferase; PNMTase",
        "protein_names_refseq": "noradrenaline N-methyltransferase; phenylethanolamine N-methylase; phenylethanolamine N-methyltransferase",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); multiple sclerosis (Disease Ontology:DOID:2377); hypoglycemia (Disease Ontology:DOID:9993)",
        "pathway": " (hsa:5409);  (R-HSA-209905)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "11237011;11591352;1540578;16277617;16363801;16942016;17322306;17845018;1857555;18767875;20496117;23186163;2590185;2835776;3372503;3443096;34933717;35051231;35269556;35580925;37952980;7961964;8101641;8812853",
        "class_list": "",
        "function": "Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review. Review article, [RefSeq, PubMed]; Overexpression of miR-375 and L-type Amino Acid Transporter 1 in Pheochromocytoma and Their Molecular and Functional Implications. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of transcutaneous electrical nerve stimulation (TENS) on pain control and phenylethanolamine-N-methyltransferase (PNMT) gene expression after cesarean section. Publication Status: Online-Only, [RefSeq, PubMed]; The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.1.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.28",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004603 phenylethanolamine N-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0032259 methylation;GO:0042418 epinephrine biosynthetic process;GO:0042423 catecholamine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "P11086-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2KHN1-1",
        "uniprot_id": [
            {
                "id": "RN151_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2KHN1",
                "type": "external"
            }
        ],
        "mass": 27412.0,
        "length": 245,
        "protein_name": "RING finger protein 151",
        "gene_name": "RNF151",
        "organism": "Human",
        "refseq_name": "RING finger protein 151 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_777563",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777563",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNF151",
        "gene_names_refseq": "RNF151",
        "protein_names_uniprotkb": "RING finger protein 151",
        "protein_names_refseq": "RING finger protein 151 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146310)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;35831855",
        "class_list": "",
        "function": "May be involved in acrosome formation of spermatids., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NHS5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q2KHN1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQV7-1",
        "uniprot_id": [
            {
                "id": "PRDM9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQV7",
                "type": "external"
            }
        ],
        "mass": 103376.0,
        "length": 894,
        "protein_name": "Histone-lysine N-methyltransferase PRDM9",
        "gene_name": "PRDM9",
        "organism": "Human",
        "refseq_name": "histone-lysine N-methyltransferase PRDM9 isoform PRDM9 A",
        "refseq_ac": [
            {
                "id": "NP_001297143",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297143",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRDM9; PFM6",
        "gene_names_refseq": "KMT8B; MEISETZ; MSBP3; PFM6; PRDM9; ZNF899",
        "protein_names_uniprotkb": "Histone-lysine N-methyltransferase PRDM9; 2.1.1.-; 2.1.1.354; 2.1.1.355; 2.1.1.359; 2.1.1.361; 2.1.1.362; PR domain zinc finger protein 9; PR domain-containing protein 9; Protein-lysine N-methyltransferase PRDM9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9",
        "protein_names_refseq": "PR domain 9; PR domain containing 9; PR domain zinc finger protein 9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9; histone methyl transferase; histone-lysine N-methyltransferase PRDM9 isoform PRDM9 A; histone-lysine N-methyltransferase PRDM9; minisatellite binding protein 3 (115kD); protein-lysine N-methyltransferase PRDM9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56979);  (R-HSA-3214841);  (R-HSA-912446)",
        "pathway_count": 3,
        "publication_count": 77,
        "publication_id_list": "10029069;10438626;10562567;10668202;10728666;10734115;10928988;10949293;11237011;11292842;11959841;12123582;12130538;12453418;12540855;12670868;14536086;14690610;14992727;15145825;15164066;15235609;15304223;15964846;16118227;16123081;16199523;16292313;16322221;16519522;16682010;16805913;17021013;17500065;17541404;17544230;17707229;17965729;17977839;17981954;18172012;18256600;18535008;18941885;19808676;20044539;20044541;20062530;20818382;21131967;21196496;21750151;21779408;21832073;22099308;22939622;24095733;24634223;26833727;27129774;28411811;29557506;29608566;30379171;32001511;32157095;35051231;35561310;36688188;37608663;38003713;8929543;9008167;9311981;9450758;9781043;9826763",
        "class_list": "",
        "function": "Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients., [RefSeq, PubMed]; Cancer Associated PRDM9: Implications for Linking Genomic Instability and Meiotic Recombination. Publication Status: Online-Only, [RefSeq, PubMed]; Each African-enhanced hotspot is activated by a distinct spectrum of PRDM9 variants, despite the fact that all are predicted to bind the same motif. This differential activation points to complex interactions between the zinc-finger array and hotspots., [RefSeq, PubMed]; FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells., [RefSeq, PubMed]; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:18941885, PubMed:24095733, PubMed:24634223, PubMed:26833727, PubMed:27129774). Can also methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability., [RefSeq, PubMed]; Results provide a molecular basis for the distribution of meiotic recombination in mammals in which the binding of PRDM9 to specific DNA sequences targets the initiation of recombination at specific locations in the genome Erratum:[Science. 2010 May 7;328(5979):690], [RefSeq, PubMed]; The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DX22;Q27Q50",
        "ec_number_list": [
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.355",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355",
                "type": "external"
            },
            {
                "id": "2.1.1.362",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362",
                "type": "external"
            },
            {
                "id": "2.1.1.361",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.372",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372",
                "type": "external"
            },
            {
                "id": "2.1.1.354",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354",
                "type": "external"
            },
            {
                "id": "2.1.1.367",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q9NQV7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20962-1",
        "uniprot_id": [
            {
                "id": "PTMS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20962",
                "type": "external"
            }
        ],
        "mass": 11530.0,
        "length": 102,
        "protein_name": "Parathymosin",
        "gene_name": "PTMS",
        "organism": "Human",
        "refseq_name": "parathymosin isoform 2",
        "refseq_ac": [
            {
                "id": "NP_002815",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002815",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTMS",
        "gene_names_refseq": "PTMS; ParaT",
        "protein_names_uniprotkb": "Parathymosin",
        "protein_names_refseq": "parathymosin isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5763)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;19204726;19608861;19651622;19773279;20068231;20237496;21406692;23186163;2537638;25576301;29393594;30192525;31154438;31222486;31844290;31848261;32157095;32350084;32387766;33592498;35251023;36241641;36284347",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042393 histone binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006260 DNA replication;GO:0002376 immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "P20962-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P29762-1",
        "uniprot_id": [
            {
                "id": "RABP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P29762",
                "type": "external"
            }
        ],
        "mass": 15566.0,
        "length": 137,
        "protein_name": "Cellular retinoic acid-binding protein 1",
        "gene_name": "CRABP1",
        "organism": "Human",
        "refseq_name": "cellular retinoic acid-binding protein 1",
        "refseq_ac": [
            {
                "id": "NP_004369",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004369",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CRABP1; RBP5",
        "gene_names_refseq": "CRABP-I; CRABP1; CRABPI; CRABP; RBP5",
        "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 1; CRABP-I; Cellular retinoic acid-binding protein I",
        "protein_names_refseq": "cellular retinoic acid-binding protein 1; cellular retinoic acid-binding protein I",
        "tax_id": 9606,
        "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (hsa:1381);  (R-HSA-5365859)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10329026;10369264;10839978;11007799;11237011;11245473;11909957;12036956;12226107;12680773;1309505;14532297;14596915;1654334;18039331;18691976;18805086;1889753;20801113;21529158;21621639;21851338;22019272;23220587;29093164;2935875;29786170;3013304;30484775;31848261;32527063;32983136;33832420;34509645;35051231;35417033;37938771;8493914;9228021;9677409;9705317",
        "class_list": "",
        "function": "CRABP1 and CRABP2 Protein Levels Correlate with Each Other but Do Not Correlate with Sensitivity of Breast Cancer Cells to Retinoic Acid., [RefSeq, PubMed]; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors., [UniProtKB]; Expression of cellular retinoic acid binding protein 1 predicts peritoneal recurrence of gastric cancer., [RefSeq, PubMed]; Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAY7;Q8WTV5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0005501 retinoid binding;GO:0001972 retinoic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0007165 signal transduction;GO:0015908 fatty acid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "P29762-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11216-1",
        "uniprot_id": [
            {
                "id": "PYGB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11216",
                "type": "external"
            }
        ],
        "mass": 96696.0,
        "length": 843,
        "protein_name": "Glycogen phosphorylase, brain form",
        "gene_name": "PYGB",
        "organism": "Human",
        "refseq_name": "glycogen phosphorylase, brain form",
        "refseq_ac": [
            {
                "id": "NP_002853",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002853",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PYGB",
        "gene_names_refseq": "GPBB; PYGB",
        "protein_names_uniprotkb": "Glycogen phosphorylase, brain form; 2.4.1.1",
        "protein_names_refseq": "brain; glycogen phosphorylase, brain form; phosphorylase, glycogen",
        "tax_id": 9606,
        "disease": "glycogen storage disease (Disease Ontology:DOID:2747)",
        "pathway": " (hsa:5834);  (R-HSA-6798695);  (R-HSA-70221)",
        "pathway_count": 3,
        "publication_count": 120,
        "publication_id_list": "10.1101/2023.09.13.557529;10487978;10949035;11237011;12604216;12665801;12825073;12930917;13115432;15118078;17081983;18083107;18323634;19531498;20068231;21209280;21767668;23650620;24029068;24366607;24715725;25576301;25645385;25880248;2615594;26375851;2667896;26768311;26853435;26992070;27402852;27600516;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29437277;29508533;29557506;2961257;29632046;29786170;30315122;30397120;30429286;30484775;3049072;30524438;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32462986;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33298915;33392160;3346228;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34211107;34229054;34405274;34509645;34561969;34725712;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37217939;38483604;38665916;4829444;5264799;5461220;7847371;7902568;8420990;8692836;8755644;8896567;9504428;9691087",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB]; Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228)., [UniProtKB, PubMed, PubMed]; PYGB Promoted Tumor Progression by Regulating Wnt/beta-Catenin Pathway in Gastric Cancer., [RefSeq, PubMed]; The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]., [RefSeq]; Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1153,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96AK1;Q9NPX8",
        "ec_number_list": [
            {
                "id": "4.6.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19",
                "type": "external"
            },
            {
                "id": "3.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24",
                "type": "external"
            },
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.2.1.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.21.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.16.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5",
                "type": "external"
            },
            {
                "id": "3.4.16.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            },
            {
                "id": "3.1.6.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "3.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
                "type": "external"
            },
            {
                "id": "3.4.21.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.6.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.4.14.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "6.3.4.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21",
                "type": "external"
            },
            {
                "id": "1.8.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
            },
            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
                "type": "external"
            },
            {
                "id": "3.4.14.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2",
                "type": "external"
            },
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008184 glycogen phosphorylase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0005980 glycogen catabolic process;GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "P11216-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H8P0-1",
        "uniprot_id": [
            {
                "id": "SR5A3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H8P0",
                "type": "external"
            }
        ],
        "mass": 36521.0,
        "length": 318,
        "protein_name": "Polyprenal reductase",
        "gene_name": "SRD5A3",
        "organism": "Human",
        "refseq_name": "polyprenal reductase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_078868",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078868",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SRD5A3; SRD5A2L",
        "gene_names_refseq": "CDG1P; CDG1Q; KRIZI; S5AR 3; S5AR; SRD5A2L1; SRD5A2L; SRD5A3",
        "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.22; 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; S5AR 3; SR type 3; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3",
        "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)); 3-oxo-5-alpha-steroid 4-dehydrogenase 3; SR type 3; polyprenal reductase isoform 1; polyprenal reductase; probable polyprenol reductase",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); Kahrizi syndrome (Disease Ontology:DOID:0050807); congenital disorder of glycosylation Iq (Disease Ontology:DOID:0080568)",
        "pathway": " (hsa:79644);  (R-HSA-193048);  (R-HSA-446199);  (R-HSA-4755579)",
        "pathway_count": 4,
        "publication_count": 77,
        "publication_id_list": "10406467;11237011;12213788;1279965;14652022;1712709;17273964;17986282;18271001;18318566;18781183;1944596;19879888;19936164;20637498;20700148;20852264;21295283;21572394;2197970;22240719;2243100;2339109;24433453;2534550;25418920;25961201;26219881;26758079;26855069;26992070;27480077;28218747;28253385;28904123;29393594;29437277;29493099;29557506;29632046;29786170;29998879;30019980;30315122;30410026;31154438;31217245;31638560;31844290;31848261;3207614;32157095;32387766;32897882;33229626;33403770;33912179;33968037;34171305;34465365;35051231;35318648;35339718;35580925;36439385;37069668;3783591;38821050;39340288;6243292;7374371;8075637;8547185;8626466;9208814;9536209;9871428",
        "class_list": "glycogene",
        "function": "Analysis of the implication of steroid 5 alpha-reductase 3 on prognosis and immune microenvironment in Liver Hepatocellular Carcinoma., [RefSeq, PubMed]; Findings indicate that a novel type 3 5 alpha-steroid reductase, SRD5A3, is associated with DHT production and maintenance of androgen-androgen receptor-pathway activation in prostate cancer., [RefSeq, PubMed]; Next generation sequencing identified a homozygous frameshift mutation (c.203dupC; p.Phe69LeufsX2) SRD5A3 as the disease-causing change in Kahrizi syndrome., [RefSeq, PubMed]; Over-expression of SRD5A3 and its prognostic significance in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; SRD5A3-CDG: 3D structure modeling, clinical spectrum, and computer-based dysmorphic facial recognition., [RefSeq, PubMed]; Steroid 5 alpha-reductase 3 (SRD5A3) promotes tumor growth and predicts poor survival of human hepatocellular carcinoma (HCC)., [RefSeq, PubMed]; Study of a large consanguineous Emirati family showed that loss of function mutations of the SRD5A3 gene cause a multisystemic syndrome with eye malformations, cerebellar vermis hypoplasia, and psychomotor delay., [RefSeq, PubMed]; The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 395,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4W5Q6",
        "ec_number_list": [
            {
                "id": "1.3.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22",
                "type": "external"
            },
            {
                "id": "1.3.1.94",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity;GO:0160198 polyprenal reductase activity;GO:0102389 polyprenol reductase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0016095 polyprenol catabolic process;GO:0043048 dolichyl monophosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9H8P0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P28066-1",
        "uniprot_id": [
            {
                "id": "PSA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P28066",
                "type": "external"
            }
        ],
        "mass": 26411.0,
        "length": 241,
        "protein_name": "Proteasome subunit alpha type-5",
        "gene_name": "PSMA5",
        "organism": "Human",
        "refseq_name": "proteasome subunit alpha type-5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001186701",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186701",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMA5",
        "gene_names_refseq": "PSC5; PSMA5; ZETA",
        "protein_names_uniprotkb": "Proteasome subunit alpha type-5; Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome subunit alpha-5; Proteasome zeta chain; alpha-5",
        "protein_names_refseq": "alpha-5; epididymis tissue sperm binding protein Li 11n; macropain subunit zeta; macropain zeta chain; multicatalytic endopeptidase complex zeta chain; proteasome (prosome, macropain) subunit, alpha type, 5; proteasome alpha 5 subunit; proteasome component 5; proteasome subunit alpha 5; proteasome subunit alpha type-5 isoform 2; proteasome subunit alpha type-5; proteasome subunit zeta; proteasome zeta chain",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:5686);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-6798695);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9912633);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 70,
        "publication_count": 1088,
        "publication_id_list": "10023660;10066435;10075690;10092233;10187770;10196136;10205060;10215629;10230406;10321728;10323868;10339564;10375532;10411507;10421629;10433824;10444327;10470034;10484077;10514424;10514433;10535940;10559216;10559916;10564661;10572046;10581160;10593898;10597293;10665657;10679238;10693759;10698680;10702308;10716940;10733526;10748049;10779524;10797013;10811609;10823831;10827953;10838074;10854325;10878807;10882101;10884341;10911365;10918611;10944113;10966113;10973495;10973499;10975528;10982817;10984056;10995389;11024059;11027307;11035045;11046155;11053425;11057907;11062501;11069780;11081627;11090634;11094434;11125146;11146634;11231585;11239468;11248027;11259415;11262391;11285280;11292861;11292862;11298456;11325957;11350924;11358837;11358993;11371342;11454738;11460167;11486055;11493923;11504826;11504942;11509732;11520989;11562349;11562789;11566882;11584266;11585840;11598268;11606584;11733065;11739726;11771738;11772397;11804587;11812794;11842200;11847229;11884229;11923872;11931757;11960000;11960013;11961546;11970895;12000792;12050670;12061891;12068298;12070128;12070292;12101228;12118249;12123571;12136087;12138125;12181345;12186903;12194817;12198130;12234927;12297295;12351678;12359729;12379217;12379510;12399544;12403779;12426310;12446569;12473183;12473184;12496252;12504025;12504026;12526791;12538644;12538665;12546821;12554650;12600938;12604685;12609982;12615973;12646216;12646235;12660156;12660731;12676583;12676925;12682069;12700136;12724779;12738770;12750368;12759351;12759363;12787671;12788921;12791267;12791687;12808096;12816948;12819195;12820959;12821933;12853446;12860405;1286667;12912907;12915405;12917689;12917691;12923053;12963847;1352877;1356264;1359686;1377674;14514672;14517290;14517306;14528300;14528312;14564014;14585973;14603323;14611647;14625308;14661020;14661924;14672932;14676825;14681206;14684739;14688281;14690597;14695475;14707141;14734113;14757770;14764894;15014503;15029244;15053880;15075292;15084608;15105418;15115751;15122200;15125833;15138260;15140882;15145317;15163793;15175422;15198976;15199159;15224091;15224092;15226418;15244466;15247232;15257295;15282312;15292211;15300262;15302935;15327769;15327770;15340381;15361859;15367669;15371334;15469821;15469984;15472518;15474027;15537541;15538386;15541657;15571818;15572695;15574592;15577943;15592474;15601839;15611333;15652483;15652751;15664193;15678106;15678131;15683364;15688063;15694336;1570011;15703179;15735151;15735756;15737063;15749015;15781449;15799966;15831487;15845454;15863492;15899824;15916963;15917222;15917247;15937478;15944226;15983046;15987702;16056267;16061793;16115867;16136078;16140942;16155214;16171779;16186825;16209941;16214042;16251969;16252004;16282375;16286508;16301747;16303288;16335952;16341139;16356853;16356855;16356856;16359182;16360641;16371461;16371649;16401342;16413484;16421188;16421275;16446366;16459297;16459298;16478641;16547496;16547521;16551619;16556936;16595681;16611729;16611981;16612002;16647857;16651542;16687519;16705181;16707496;16728642;16732330;16738327;16740475;16753179;16790436;16816140;16818754;16824194;16831874;16849449;16884355;16901786;16901789;16906146;16931761;16943200;16954532;1695717;16962933;16964243;16964248;16971392;16973613;16978534;16980583;16990800;17047224;17072321;17081101;17081983;17115028;17126548;17132228;17135271;17139257;17141195;17158449;17161475;17182618;17183061;17183367;17187060;17189198;17204608;17218260;17220875;17234884;17254968;17283082;17290220;17318175;17322306;17323924;17332328;17363905;17395884;17428801;17434750;17442700;17443180;17468049;17485488;17496917;17497243;17507369;17507410;17510365;17512459;17523162;17540904;17548359;1756723;17636564;17641202;17675297;17697703;17728103;17728323;17785452;17786208;17855752;17873522;17890055;17894550;17900240;17924679;17947239;17948026;17948050;17977821;17979524;17980597;17981138;17997719;18031682;18070982;18093314;18162290;18167338;18172164;18180283;18184961;18206966;18235225;18238777;18248330;18249105;18264092;18273910;18280240;1828071;18281465;18282684;1833184;18337469;18434309;18438411;18455992;18462924;18467330;18480045;18485873;18497258;18497827;18502753;18534984;18541707;18555777;18573886;18593949;18632802;18632848;18635759;18636086;18644862;18662542;18669648;18691976;18692471;18701449;18711132;18716059;18719096;18720373;18767875;18772140;18775313;18776931;18805092;18826954;18827223;18832070;18851830;1888762;18926707;18984734;18997792;18997794;19002207;19015242;19028597;19056373;19061640;19066035;19081070;19122653;19125156;19135894;19166925;19188362;19188440;19208626;19217269;19250909;19264966;19305393;19317650;19321346;19345329;19346256;19352404;19359218;19363159;19368795;19371734;19379695;19398555;19413330;19415658;19424180;19447222;19452197;19473979;19473982;19489725;19490896;19513348;19533801;19549984;19570978;19573811;19592253;19593530;19603532;19617556;19622347;19651622;19664995;19666503;1968359;19684112;19706539;19729658;19734889;19734940;19748355;19759537;19808967;19815541;19815555;19818708;19838211;19851334;19852954;19862647;19874575;19874889;19878745;19896182;19903815;19909372;19910467;19934406;19940261;19955409;1998343;19996169;20014402;20016067;20018861;20028659;20038579;20058876;20068231;20096447;20100835;20104595;20154143;20193029;20227366;20228808;20236090;20300203;20348946;20360384;20368735;20378532;20436459;20449947;20452972;20460306;20471946;20487519;20495340;20501646;20501935;20512148;20536836;20538596;20543837;20577264;20583968;20585641;20621639;20643644;20685844;20734105;20805357;20818436;20844016;20849292;20858899;20887958;20889716;20956384;21081755;21083385;21091114;21177870;2121370;21220506;21239494;21245377;21252624;21257310;21317288;21329875;21329882;21335549;2135388;21357747;21362556;21372320;21391649;2139180;21447816;21463634;21478859;2147937;21525931;21532586;21571218;21571647;21596315;21652558;21659512;21695114;21734707;21778237;21799911;21801010;2183031;21849505;21863050;21878643;21921029;21931630;21940857;21962518;21966355;21983142;22007132;22012064;22029577;22036506;22047557;22069318;22085928;22101459;2210768;22117219;22128162;22142471;22153078;22178883;22216260;22265677;22267219;22279049;22286099;22299025;22306028;22306998;22318583;2236053;22391301;22422618;22427670;22440753;22466964;22505454;22508986;22537386;2261476;22645359;22718757;22751498;22751928;22761442;22789539;22798961;22800433;22802525;22872865;22885700;22897851;22898188;22959436;22964642;22982193;23063411;23069990;23112049;23140627;23144924;23159851;23186163;23201271;23217742;23236459;23256519;23274085;23301498;23332756;23333304;23333871;23395819;23401859;23403054;23419514;23443682;23452856;23453757;23481700;23486064;23495936;23535009;23535662;23535663;23563313;23579495;23583660;23603117;23613522;23650620;23661552;23685075;23719536;23719902;23725801;23746841;23824326;23825189;23851460;23867461;23878308;23907514;23912815;23943595;23955340;23986495;24011591;24019521;2405250;24056413;24072710;24074955;24076655;24260525;24270891;24298019;24302888;24309468;24366543;24367090;24493797;24582806;24585635;24636985;24685677;24714562;24715725;2475911;24784881;24793695;24793696;24814062;24845016;24854174;24896179;24925320;25040165;25043025;25083866;25132172;25133187;25152365;25197364;25231993;25242263;25253721;25260729;25305019;2530630;25314029;25339975;25349211;25355947;25394790;25502872;25531226;25547115;25576301;25578727;25578875;25584290;25599644;25645385;25654763;2570070;2570460;25733683;25740432;25793262;25892735;25921531;26024233;26091038;26117325;26133119;26154972;26183061;26208431;26222030;26280083;26280536;26344709;26374642;26375851;26443277;26460955;26583321;26632597;26728094;26768311;26778333;26811146;26906416;26942676;26992070;27030794;27137657;27176742;27222660;27249176;27342858;27428775;27466718;27493187;27565346;27572267;27600516;27726376;27846572;27920218;28115426;28132103;28178531;28218747;28228285;28263418;28317937;28380357;28442575;28467828;28510447;28514659;28598414;28832583;28834231;28904123;2898143;29055231;29153394;29233872;29242379;29314611;29356040;29393594;29437277;29450944;2946959;29493099;29508533;29526543;29557506;29632046;29632312;29717933;29769354;29786170;30118680;30192525;30244831;30315122;30334692;30334693;30410026;30429286;30484775;30610225;30626607;30728908;30779550;30833945;31011209;31020640;31217245;31222486;3129195;31530632;31546975;31679946;31844290;31848261;31937595;32005965;32157095;32161166;32284348;32293500;32350084;32357974;32387766;32488085;32502341;32640524;32672401;32897882;32938616;32981041;32983136;33009401;33043033;33141586;33298915;33392160;33406423;33444648;33465208;33592498;33633747;33691108;33717175;33791708;33859744;33909987;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34215617;34315872;34357683;34405274;34509645;34561969;3457471;34711951;3472246;34725712;34932366;35051231;35154160;35251023;35385574;35580925;36010968;36198437;36215666;36241641;36284347;37217939;37676773;38415977;38665916;40136647;40596516;40914422;7479848;7479976;7499357;7510216;7512451;7523390;7529176;7544915;7553863;7553864;7559638;7575604;7578059;7612269;7628694;7639698;7799959;7809113;7811704;7831327;7862124;7865904;7885476;7957109;7985023;8107774;8140422;8234276;8327496;8332913;8387275;8521496;8550590;8563751;8599092;8601309;8610016;8626374;8662591;8662795;8670417;8689684;8692836;8702708;8706131;8824192;8837778;8896571;8921937;8972730;9029102;9122164;9135156;9136925;9219684;9230313;9247583;9252186;9302992;9315679;9346238;9346484;9362451;9371760;9372967;9380723;9430229;9482734;9520446;9528852;9535855;9593755;9601642;9628874;9635433;9652413;9660940;9668046;9674432;9687533;9721103;9742107;9747882;9790970;9816258;9831708;9844631;9859996;9874371;9887101;9891082;9892021;9914500;9990852;9990853",
        "class_list": "",
        "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, PubMed]; Knockdown of liver cancer cell-secreted exosomal PSMA5 controls macrophage polarization to restrain cancer progression by blocking JAK2/STAT3 signaling., [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8F6;B4E2V4;Q3T1C1;Q6IBF7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045061 thymic T cell selection;GO:0045063 T-helper 1 cell differentiation;GO:0071357 cellular response to type I interferon;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 109.4,
        "record_id": "P28066-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NV39-1",
        "uniprot_id": [
            {
                "id": "PRR34_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NV39",
                "type": "external"
            }
        ],
        "mass": 14718.0,
        "length": 138,
        "protein_name": "Proline-rich protein 34",
        "gene_name": "PRR34",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PRR34; C22orf26",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Proline-rich protein 34",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "26992070;31844290;32502341",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QZ24",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q9NV39-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13207-1",
        "uniprot_id": [
            {
                "id": "TBX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13207",
                "type": "external"
            }
        ],
        "mass": 75066.0,
        "length": 712,
        "protein_name": "T-box transcription factor TBX2",
        "gene_name": "TBX2",
        "organism": "Human",
        "refseq_name": "T-box transcription factor TBX2",
        "refseq_ac": [
            {
                "id": "NP_005985",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005985",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBX2",
        "gene_names_refseq": "TBX2; VETD",
        "protein_names_uniprotkb": "T-box transcription factor TBX2; T-box protein 2",
        "protein_names_refseq": "T-box 2; T-box protein 2; T-box transcription factor TBX2",
        "tax_id": 9606,
        "disease": "vertebral anomalies and variable endocrine and T-cell dysfunction (Disease Ontology:DOID:0070345); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); heart septal defect (Disease Ontology:DOID:1681); atrial heart septal defect (Disease Ontology:DOID:1882)",
        "pathway": " (hsa:6909);  (R-HSA-9825892)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10770922;11062467;11111039;11237011;12000749;20360007;21403123;22002537;22647378;22844464;23186163;25142731;25645385;26486273;26992070;27600516;28910203;29242379;29351928;29508533;29557506;29726930;30379171;30429286;30599067;30833945;31154438;31530632;31844290;32157095;32350084;32387766;32488085;32938616;34064060;34087483;34171305;34357683;35051231;35254053;35580925;35715550;35891763;36017860;36478592;37938771;38665916;7987387;8343963;8530034;8597636;9710594",
        "class_list": "",
        "function": "A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes., [RefSeq, PubMed]; Clinical and Genetic Characteristics of Preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; T-Box Transcription Factor 2 Enhances Chemoresistance of Endometrial Cancer by Mediating NRF2 Expression., [RefSeq, PubMed]; T-box transcription factor 2 mediates antitumor immune response in cutaneous squamous cell carcinoma by regulating the expression of programmed death ligand 1., [RefSeq, PubMed]; TBX2, a Novel Regulator of Labour. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16424;Q7Z647",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0097325 melanocyte proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q13207-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BVK6-1",
        "uniprot_id": [
            {
                "id": "TMED9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BVK6",
                "type": "external"
            }
        ],
        "mass": 27277.0,
        "length": 235,
        "protein_name": "Transmembrane emp24 domain-containing protein 9",
        "gene_name": "TMED9",
        "organism": "Human",
        "refseq_name": "transmembrane emp24 domain-containing protein 9 precursor",
        "refseq_ac": [
            {
                "id": "NP_059980",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059980",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMED9; GP25L2",
        "gene_names_refseq": "GMP25; HSGP25L2G; TMED9; p24a2; p24alpha2; p25",
        "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 9; GMP25; Glycoprotein 25L2; p24 family protein alpha-2; p24alpha2; p25",
        "protein_names_refseq": "glycoprotein 25L2; p24 family protein alpha-2; transmembrane emp24 domain-containing protein 9 precursor; transmembrane emp24 protein transport domain containing 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54732);  (R-HSA-6807878);  (R-HSA-6811434)",
        "pathway_count": 3,
        "publication_count": 211,
        "publication_id_list": "10.1101/2023.09.13.557529;10052452;10318838;10359607;10445031;10559959;10679020;10761932;10852829;10903204;10921873;11035033;11172815;11285137;11306556;11461920;11493604;11689559;11703931;11726511;11739780;11748249;12047556;12070132;12237308;12388752;12634853;12754519;14504276;14600267;14654841;14742712;15029241;15037235;15272311;15537668;15616190;15632110;15728195;15813748;15878873;16030262;1631136;16571679;16595549;16633337;16723730;1680566;16912714;16926190;16940185;17113389;17253781;17274799;17360540;17429068;17451557;17760859;17927562;17956946;18086915;18182008;18283113;18287528;18524849;18809720;1898986;19015319;19109418;19151722;19159218;19164740;19296914;19369418;1957170;19631211;19758564;19948005;20005805;20136777;20357002;20427317;20462495;20534429;20637885;21219331;21545355;21550981;21689688;21844168;22013193;22094269;22304919;22424782;22544926;22898188;23090970;23396477;23481700;23839779;24119662;24190977;24714562;24715725;24806965;25364732;25436559;25492864;25502872;25505266;25576301;25645385;26154972;26728094;26992070;27600516;27846572;27862975;27920218;28228285;28832583;28834231;28904123;29242379;29314611;29437277;29493099;29508533;29557506;29632711;29741879;29786170;30315122;30410026;30429286;30444036;30524438;30779550;31154438;31217245;31253868;31844290;31848261;31937595;31998317;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33691108;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34357683;34405274;34433824;34509645;34635011;34725712;34932366;35051231;35251023;35580925;36010968;36215666;36241641;36284347;37074911;37217939;37938771;38665916;39303030;7691276;7844144;8001155;8128252;8132710;8221884;8253837;8505331;8620540;8636227;8991093;9114004;9150144;9177194;9244307;9288971;9323141;9380700;9382863;9405360;9490716;9671725;9751720;9990005",
        "class_list": "",
        "function": "Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma., [RefSeq, PubMed]; Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway., [RefSeq, PubMed]; TMED9/TMED3 antagonism impacts WNT-TCF and GLI signaling, where TMED9 primacy over TMED3 leads to the establishment of a positive feedback loop together with CNIH4, TGFalpha, and GLI1 that enhances metastases, [RefSeq, PubMed]; This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14437;Q8WZ61",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019905 syntaxin binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0010638 positive regulation of organelle organization;GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 22.7,
        "record_id": "Q9BVK6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000001000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NBS9-1",
        "uniprot_id": [
            {
                "id": "TXND5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NBS9",
                "type": "external"
            }
        ],
        "mass": 47629.0,
        "length": 432,
        "protein_name": "Thioredoxin domain-containing protein 5",
        "gene_name": "TXNDC5",
        "organism": "Human",
        "refseq_name": "thioredoxin domain-containing protein 5 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001139021",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139021",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TXNDC5; PRO700; TLP46",
        "gene_names_refseq": "ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8; TXNDC5; UNQ364",
        "protein_names_uniprotkb": "Thioredoxin domain-containing protein 5; 1.8.4.-; 5.3.4.1; ER protein 46; ERp46; Endoplasmic reticulum resident protein 46; Thioredoxin-like protein p46",
        "protein_names_refseq": "ER protein 46; endoplasmic reticulum protein ERp46; endoplasmic reticulum resident protein 46; endothelial protein disulphide isomerase; epididymis secretory sperm binding protein; protein disulfide isomerase family A, member 15; thioredoxin domain containing 5 (endoplasmic reticulum); thioredoxin domain-containing protein 5 isoform 3; thioredoxin related protein; thioredoxin-like protein p46",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81567);  (R-HSA-432720);  (R-HSA-432722);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 112,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10394364;10436028;11139587;11333915;11590181;11604418;11694590;11994746;12963716;12975309;15102850;16155256;16867982;17116749;17895523;19559397;19651769;20068231;20230749;20708039;21620353;22661428;23481700;23584533;23650620;24190977;24714562;24715725;25418920;25576301;25645385;25813380;25880248;26154972;26853435;26992070;27600516;27846572;27920218;28228285;28446606;28467828;28514659;28832583;28834231;29242379;29493099;29508533;29557506;29632711;29786170;30315122;30410026;30429286;30459171;30779550;31154438;31217245;31844290;32119511;32157095;32161166;32350084;32488085;32502341;32938616;32983136;33141586;33214551;33298915;33465208;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34211107;34229054;34357683;34433824;34725712;35051231;35083852;35132862;35154160;35251023;35318648;35494241;35580925;35934705;36050716;36106447;36241641;37938771;38548704;38629066;38665916;38838015;39302247;40307207;40596516;8374173;8524399;8670264;8692836;9733768",
        "class_list": "",
        "function": "Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release., [RefSeq, PubMed]; Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis., [RefSeq, PubMed]; Member of the protein disulphide isomerase family and highly expressed in endothelial cells.  Protects endothelial cells from apoptosis under hypoxia., [RefSeq, PubMed]; Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds., [UniProtKB, UniProtKB]; The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The role and mechanism of TXNDC5 in disease progression. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The role and mechanism of TXNDC5 in diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]., [RefSeq]; Upregulation of TXNDC5 are involved in the early development of colorectal cancer, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDM2;Q5TCQ0;Q8ND33;Q8TCT2;Q9BVH9",
        "ec_number_list": [
            {
                "id": "3.1.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1",
                "type": "external"
            },
            {
                "id": "4.6.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19",
                "type": "external"
            },
            {
                "id": "3.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "1.11.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.2.1.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52",
                "type": "external"
            },
            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.21.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20",
                "type": "external"
            },
            {
                "id": "4.6.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18",
                "type": "external"
            },
            {
                "id": "3.4.16.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5",
                "type": "external"
            },
            {
                "id": "3.4.16.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "2.4.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1",
                "type": "external"
            },
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            },
            {
                "id": "3.1.6.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8",
                "type": "external"
            },
            {
                "id": "3.1.6.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14",
                "type": "external"
            },
            {
                "id": "3.1.6.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12",
                "type": "external"
            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
                "type": "external"
            },
            {
                "id": "3.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
                "type": "external"
            },
            {
                "id": "3.4.21.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "3.1.6.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.3.3.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8",
                "type": "external"
            },
            {
                "id": "3.4.14.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "6.3.4.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21",
                "type": "external"
            },
            {
                "id": "1.8.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
            },
            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
                "type": "external"
            },
            {
                "id": "3.4.18.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
                "type": "external"
            },
            {
                "id": "3.4.14.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2",
                "type": "external"
            },
            {
                "id": "3.5.3.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q8NBS9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75691-1",
        "uniprot_id": [
            {
                "id": "UTP20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75691",
                "type": "external"
            }
        ],
        "mass": 318385.0,
        "length": 2785,
        "protein_name": "Small subunit processome component 20 homolog",
        "gene_name": "UTP20",
        "organism": "Human",
        "refseq_name": "small subunit processome component 20 homolog",
        "refseq_ac": [
            {
                "id": "NP_055318",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055318",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UTP20; DRIM",
        "gene_names_refseq": "1A6/DRIM; DRIM; UTP20",
        "protein_names_uniprotkb": "Small subunit processome component 20 homolog; Down-regulated in metastasis protein; NNP73; Novel nucleolar protein 73; Protein Key-1A6",
        "protein_names_refseq": "NNP73; UTP20 small subunit (SSU) processome component; UTP20, small subunit (SSU) processome component, homolog; down regulated in metastasis; down-regulated in metastasis protein; novel nucleolar protein 73; small subunit processome component 20 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27340);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 169,
        "publication_id_list": "10606270;11081632;11790298;11922599;11935223;11978965;12068309;12150911;12417735;12429849;15199136;16037817;16043514;16053918;16381836;16458307;16565220;16738141;16782898;16959974;17189298;17353269;17412707;17498821;17547437;17636026;18065403;18438418;18669648;18691976;19033376;19106111;19332556;19463982;19564402;19664995;19690332;19691289;19801658;20038530;20047967;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21151873;21406692;22072790;22190735;22195017;22424782;22645359;22916032;23186163;23391857;23439679;23481700;23482395;2388630;24086612;24424021;24550520;24715725;25411247;25418920;25525153;25576301;25645385;25653167;25851604;25880248;25892735;25969445;26085946;26154972;26196125;26237581;26992070;27084949;27600516;27846572;27862975;27920218;28159928;28218747;28228285;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30410026;30429286;30484775;30779550;30833945;31092671;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34516797;34561969;34932366;35051231;35083852;35154160;35318648;35494241;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37938771;39302247;9211966;9482744;9512526;9673349",
        "class_list": "",
        "function": "1A6/DRIM activates Pol I transcription most likely by associating with both hALP and UBF and thereby affecting the acetylation of UBF Publication Status: Online-Only, [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA., [UniProtKB, PubMed, PubMed]; UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H3H4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 17.2,
        "record_id": "O75691-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.001000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O76054-1",
        "uniprot_id": [
            {
                "id": "S14L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O76054",
                "type": "external"
            }
        ],
        "mass": 46145.0,
        "length": 403,
        "protein_name": "SEC14-like protein 2",
        "gene_name": "SEC14L2",
        "organism": "Human",
        "refseq_name": "SEC14-like protein 2 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001191133",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191133",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEC14L2; C22orf6; KIAA1186; KIAA1658",
        "gene_names_refseq": "C22orf6; SEC14L2; SPF; TAP1; TAP",
        "protein_names_uniprotkb": "SEC14-like protein 2; Alpha-tocopherol-associated protein; SPF; Squalene transfer protein; Supernatant protein factor; TAP; hTAP",
        "protein_names_refseq": "SEC14-like protein 2 isoform 3; SEC14-like protein 2; alpha-tocopherol-associated protein; squalene transfer protein; supernatant protein factor; tocopherol-associated protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23541)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10829015;11226224;11237011;11444841;12429094;18477386;26266980;27600516;28463110;29557506;30379171;30472319;30779550;31222486;31844290;31851620;32157095;32938616;33592498;33981976;35051231;36215666;36477533;37116384;38349410",
        "class_list": "",
        "function": "Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell., [UniProtKB]; Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells., [RefSeq, PubMed]; Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC). Publication Status: Online-Only, [RefSeq, PubMed]; SEC14L2 enabled RNA replication of diverse HCV genotypes in several human hepatoma cell lines, [RefSeq, PubMed]; SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations., [RefSeq, PubMed]; TAP-ing into the cross-presentation secrets of dendritic cells. Review article, [RefSeq, PubMed]; This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z8Q1;F5H3U4;Q53EQ2;Q6PD61;Q9ULN4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008431 vitamin E binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045540 regulation of cholesterol biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "O76054-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BQ52-1",
        "uniprot_id": [
            {
                "id": "RNZ2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BQ52",
                "type": "external"
            }
        ],
        "mass": 92219.0,
        "length": 826,
        "protein_name": "Zinc phosphodiesterase ELAC protein 2",
        "gene_name": "ELAC2",
        "organism": "Human",
        "refseq_name": "zinc phosphodiesterase ELAC protein 2 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001159434",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159434",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELAC2; HPC2",
        "gene_names_refseq": "COXPD17; ELAC2; ELC2; HPC2",
        "protein_names_uniprotkb": "Zinc phosphodiesterase ELAC protein 2; 3.1.26.11; ElaC homolog protein 2; Heredity prostate cancer protein 2; RNase Z 2; Ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2",
        "protein_names_refseq": "RNase Z 2; elaC homolog 2; elaC homolog protein 2; elaC-like protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; zinc phosphodiesterase ELAC protein 2 isoform 3; zinc phosphodiesterase ELAC protein 2",
        "tax_id": 9606,
        "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 17 (Disease Ontology:DOID:0111496); infantile hypertrophic cardiomyopathy (Disease Ontology:DOID:0111753); prostate cancer (Disease Ontology:DOID:10283); prostate cancer, hereditary, 2 (MONDO:MONDO:0013872)",
        "pathway": " (hsa:60528);  (R-HSA-6784531);  (R-HSA-6785470);  (R-HSA-8868766);  (R-HSA-9708296)",
        "pathway_count": 5,
        "publication_count": 164,
        "publication_id_list": "10444065;10986046;11175785;11237011;11254448;11254449;11455963;11504732;11507049;11522646;11727826;11871657;12138183;12515253;12522685;12526808;12621050;12711671;12729736;12783937;12949798;1400510;14504198;14625808;15109492;15317868;16361254;16636667;16710424;17204286;17224653;17322306;18226598;18669648;18809514;18984158;18987736;19114040;19332886;19651622;19729508;19850906;19933153;20068231;20129916;20231859;21311021;21450806;21559454;21593607;21855800;21857155;22336717;22869377;22944664;22991464;23042678;23183536;23186163;23297232;23481700;23849775;24052700;24275569;24366607;24703694;2470644;24715725;24870230;25193871;25270025;25567797;25576301;25640237;25645385;25652405;25810538;25849199;25892735;25925575;25928769;25953853;26016801;26124144;26154972;26375851;26811146;26992070;2730651;27345152;27846572;27920218;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;29844106;30192525;30315122;30379171;30410026;30484775;30524438;31582561;31844290;32138588;32157095;32357974;32387766;32488085;32502341;32592348;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34509645;34932366;35051231;35083852;35138101;35318648;35580925;36010968;36215666;36241641;36284347;37353407;37938771;39894887;40914422;6930639;7759547;7828588;9512417;9660920",
        "class_list": "",
        "function": "A Study of Ser217Leu and Ala541Thr Polymorphism in the Men Afflicted with Prostate Cancer and in the Men being Suspicious of Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Candidate prostate cancer susceptibility gene ELAC2 potentiates TGF-beta/Smad-induced transcriptional responses, [RefSeq, PubMed]; ELAC2 harbors mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two Utah pedigrees, [RefSeq, PubMed]; ELAC2 is a functional prostate cancer risk allele., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]; Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DPL9;Q6IA94;Q9HAS8;Q9HAS9;Q9NVT1",
        "ec_number_list": [
            {
                "id": "3.1.26.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.5",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.218",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218",
                "type": "external"
            },
            {
                "id": "2.1.1.221",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221",
                "type": "external"
            },
            {
                "id": "1.1.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35",
                "type": "external"
            },
            {
                "id": "1.1.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62",
                "type": "external"
            },
            {
                "id": "1.1.1.239",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239",
                "type": "external"
            },
            {
                "id": "1.1.1.178",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178",
                "type": "external"
            },
            {
                "id": "1.1.1.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53",
                "type": "external"
            },
            {
                "id": "1.1.1.159",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159",
                "type": "external"
            },
            {
                "id": "3.1.26.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0042781 3'-tRNA processing endoribonuclease activity;GO:0004549 tRNA-specific ribonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0016078 tRNA decay;GO:0042780 tRNA 3'-end processing;GO:0090646 mitochondrial tRNA processing;GO:1990180 mitochondrial tRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 16.7,
        "record_id": "Q9BQ52-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P27635-1",
        "uniprot_id": [
            {
                "id": "RL10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P27635",
                "type": "external"
            }
        ],
        "mass": 24577.0,
        "length": 214,
        "protein_name": "Large ribosomal subunit protein uL16",
        "gene_name": "RPL10",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL16 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001243506",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243506",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPL10; DXS648E; QM",
        "gene_names_refseq": "AUTSX5; DXS648E; DXS648; L10; MRXS35; NOV; QM; RPL10; uL16",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL16; 60S ribosomal protein L10; Laminin receptor homolog; Protein QM; Ribosomal protein L10; Tumor suppressor QM",
        "protein_names_refseq": "60S ribosomal protein L10; Wilms tumor-related protein; laminin receptor homolog; large ribosomal subunit protein uL16 isoform b; large ribosomal subunit protein uL16; tumor suppressor QM",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); syndromic X-linked mental retardation 35 (Disease Ontology:DOID:0080241); autistic disorder (Disease Ontology:DOID:12849); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); autism, susceptibility to, X-linked 5 (MONDO:MONDO:0010449)",
        "pathway": " (hsa:6134);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 17,
        "publication_count": 236,
        "publication_id_list": "10358005;10659855;1095581;10970870;10982836;11018020;11018027;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11922599;11964406;12068309;12138090;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;12962325;1303197;1339145;1400365;14527413;14567916;14630918;14636577;14654843;14742663;14973490;15034551;15317934;1534224;15385533;15534230;15546618;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16452507;16469117;1658743;16601204;16622410;16627977;16630668;16738141;16940977;16989641;17053788;17142313;17189298;17267404;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18258260;18285520;18423202;18438418;18447580;18447585;18455985;18524595;18539146;1856230;1861871;18657639;18974281;18991276;19060897;19106111;19150429;19332556;19359157;19417104;19478851;19503078;19556969;19564402;19608919;19706539;19801658;19859661;19909264;20023408;20038530;20056613;2006156;20112406;20305658;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21063389;21097556;21145460;21419344;21567917;22072790;22190735;22195017;22869377;22916032;23085078;23217742;23234702;23269699;23439679;23482395;23685075;23746841;2388630;24424021;24524803;24550520;25132172;25242263;25316788;25418920;25525153;25578875;25645385;25846674;25969445;26237581;26290468;26375851;27526673;27600516;27920218;28063628;28065601;28132843;28218747;28228285;28510447;28514659;28685749;28744013;28832583;28834231;28871256;29242379;29331515;29393594;29413899;29508533;29632046;29632312;29786170;29789417;29930300;30244831;30293783;30315122;30524438;30573663;30804176;30833945;31011209;31530632;31848261;31998317;32099016;32161166;32265295;32579943;32870666;33043033;33214551;33406423;33909987;34019948;34725712;35083852;35138101;36284347;36302773;37217939;37280198;37676773;38665916;429297;592398;592399;641056;6568109;6901506;7990965;8336711;8407925;8733135;8890909;9211906;9431993;9482744;9582194;9631292;9637248;9712840",
        "class_list": "",
        "function": "Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788)., [UniProtKB, PubMed, PubMed, PubMed]; The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A3KQT0;D3DWW6;Q16470;Q2HXT7;Q53FH7;Q6FGN8;Q8TDA5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045182 translation regulator activity;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0006412 translation;GO:0006941 striated muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 23.9,
        "record_id": "P27635-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6N7-1",
        "uniprot_id": [
            {
                "id": "ROBO1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6N7",
                "type": "external"
            }
        ],
        "mass": 180930.0,
        "length": 1651,
        "protein_name": "Roundabout homolog 1",
        "gene_name": "ROBO1",
        "organism": "Human",
        "refseq_name": "roundabout homolog 1 isoform d precursor",
        "refseq_ac": [
            {
                "id": "NP_001139317",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139317",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ROBO1; DUTT1",
        "gene_names_refseq": "CPHD8; DUTT1; NORS; NYS8; ROBO1; SAX3",
        "protein_names_uniprotkb": "Roundabout homolog 1; Deleted in U twenty twenty; H-Robo-1",
        "protein_names_refseq": "deleted in U twenty twenty; roundabout homolog 1 isoform d precursor; roundabout, axon guidance receptor, homolog 1",
        "tax_id": 9606,
        "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined or isolated pituitary hormone deficiency 8 (Disease Ontology:DOID:0061018); autosomal recessive congenital nystagmus 8 (Disease Ontology:DOID:0061178); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); plasmacytoma (Disease Ontology:DOID:3721); lung non-small cell carcinoma (Disease Ontology:DOID:3908); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538); neurooculorenal syndrome (MONDO:MONDO:0957210)",
        "pathway": " (hsa:6091);  (R-HSA-373752);  (R-HSA-376176);  (R-HSA-428540);  (R-HSA-428542);  (R-HSA-428543);  (R-HSA-428890);  (R-HSA-8985586);  (R-HSA-8985801);  (R-HSA-9010553)",
        "pathway_count": 10,
        "publication_count": 99,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10102266;10102268;10805734;10892742;11207612;11237011;11375980;11404413;12082532;12154370;12508280;15063764;16762451;17081983;17174565;17322306;17565045;17848514;18669648;18767875;19413330;19651622;19664994;19706539;19901323;20068231;20375348;21600986;23090970;23186163;23217742;23481700;23584533;23746841;24190977;24560577;24673457;24715725;24936616;25242263;25502872;25576301;25645385;26154972;26529257;26586761;27869121;28402530;28467828;29194579;29242379;29331515;29351928;29393594;29508533;29557506;30315122;30459171;31154438;31217245;31448886;31844290;31848261;31998317;32157095;32161166;32350084;32502341;32938616;33141586;33196021;33392160;33592498;33633747;33936100;33968037;34019948;34171305;34211107;34561969;35051231;35227688;35318648;35348658;36010968;36042257;36241641;36277474;36459288;37074911;38019913;38414132;9458045;9490638;9608531;9796701;9858595",
        "class_list": "",
        "function": "Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]., [RefSeq]; MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1., [RefSeq, PubMed]; NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate. Publication Status: Online-Only, [RefSeq, PubMed]; ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS., [RefSeq, PubMed]; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy., [RefSeq, PubMed]; Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 20,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 91,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 15,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RXI1;D3DU36;E9PD49;Q1RMC7;Q7Z300;Q9BUS7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0030275 LRR domain binding;GO:0008046 axon guidance receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane",
        "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q9Y6N7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z6I6-1",
        "uniprot_id": [
            {
                "id": "RHG30_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z6I6",
                "type": "external"
            }
        ],
        "mass": 118582.0,
        "length": 1101,
        "protein_name": "Rho GTPase-activating protein 30",
        "gene_name": "ARHGAP30",
        "organism": "Human",
        "refseq_name": "rho GTPase-activating protein 30 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_859071",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859071",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ARHGAP30",
        "gene_names_refseq": "ARHGAP30",
        "protein_names_uniprotkb": "Rho GTPase-activating protein 30; Rho-type GTPase-activating protein 30",
        "protein_names_refseq": "rho GTPase-activating protein 30 isoform 2; rho GTPase-activating protein 30; rho-type GTPase-activating protein 30",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:257106);  (R-HSA-8980692);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013420)",
        "pathway_count": 5,
        "publication_count": 384,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10619026;10699171;10699464;10724160;10873388;10873802;10958683;11007481;11058585;11085924;11149925;11207612;11237011;11306516;11373293;11396949;11431473;11432776;11459829;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12172552;12195014;12221077;12221096;12351724;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15144186;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15350535;15485661;15507211;15556869;15579468;15592455;15601624;15611138;15728722;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16467373;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16968698;17064668;17077126;17145773;17196961;17214551;17244649;17504809;17562871;17583407;17599059;17702745;17765681;17804252;17924679;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18218625;18249095;18347018;18363964;18396277;18426980;18653540;18786931;18829452;18835169;18838382;18929667;19064640;19269969;19494238;19605563;19635168;19673492;19690332;19713215;19901323;19934221;20030946;20058876;20101212;20400958;20460433;20547754;20591975;20628200;20660154;20679435;20810653;21148482;21351730;21454492;21508312;21542010;21565175;21613211;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22461490;22475431;22571869;22608513;22673745;22734669;22911862;22970203;22992742;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24259668;24275569;24335996;24352656;24584464;24714562;24715725;24859002;24933155;24960694;24996924;25024229;25156493;25211221;25418920;25428919;25505266;25704760;25721503;25795300;25862245;25880248;25963737;26129894;26154972;26299518;26371245;26375851;26529257;26598554;26598620;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27846572;27862975;27920218;27986909;28028151;28112683;28114311;28196833;28228285;28446606;28584191;28649982;28825699;28832583;28834231;28860633;28904123;29089502;29146911;29242379;29351928;29358323;29382922;29393594;29493099;29508533;29557506;29632711;29786170;30061681;30315122;30410026;30429286;30784271;30853411;31092671;31105010;31217245;31844290;31871319;32157095;32203420;32350084;32357974;32387766;32416689;32502341;32737221;32938616;32983136;33123756;33141586;33298915;33691108;33717175;33836029;33936100;33968037;33981976;34211107;34357683;34490691;34509645;34561969;34932366;35051231;35132862;35561310;35580925;37170915;38717936;40914422;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9792683;9822598;9822605;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor., [RefSeq, PubMed]; ArhGAP30 is required for p53 acetylation and functional activation in colorectal cancer.Down-regulation of ArhGAP30 in colorectal cancer is associated with poor survival. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42., [UniProtKB, PubMed]; KIAA1429 regulates lung adenocarcinoma proliferation and metastasis through the PI3K/AKT pathway by modulating ARHGAP30 expression., [RefSeq, PubMed]; Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis., [RefSeq, PubMed]; Potential Prognostic Predictors and Molecular Targets for Skin Melanoma Screened by Weighted Gene Co-expression Network Analysis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SY52;Q5SY53;Q5SY54;Q6ZML6;Q7Z3J8;Q86XI7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0035024 negative regulation of Rho protein signal transduction;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 38.8,
        "record_id": "Q7Z6I6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y580-1",
        "uniprot_id": [
            {
                "id": "RBM7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y580",
                "type": "external"
            }
        ],
        "mass": 30504.0,
        "length": 266,
        "protein_name": "RNA-binding protein 7",
        "gene_name": "RBM7",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 7 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001272974",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272974",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM7",
        "gene_names_refseq": "RBM7",
        "protein_names_uniprotkb": "RNA-binding protein 7; RNA-binding motif protein 7",
        "protein_names_refseq": "RNA-binding protein 7 isoform a; RNA-binding protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10179);  (R-HSA-72163);  (R-HSA-9843970);  (R-HSA-9930044)",
        "pathway_count": 4,
        "publication_count": 194,
        "publication_id_list": "10.1101/2023.09.13.557529;10882114;11014198;11101529;11233976;11237011;11991638;12176931;12411573;12414731;12477934;12634307;14625303;14713954;15302935;16263084;16314458;16809785;16964243;17095540;17174896;17332742;17412707;17606899;18212344;18322460;18593880;18669648;18707149;18767875;19103666;19165350;19536130;19664994;19664995;19690332;20058876;20068231;20166139;20423332;20871592;20980672;21536652;21705430;2176635;21855801;22022377;22110043;22365833;22658674;22959432;22961380;23186163;23222130;23236153;23345524;23783831;24129315;24196718;24275569;24304693;24448447;24737827;24914973;25189701;25489052;25525152;25555158;25576301;25578728;2558966;25645385;25852104;25892735;26022416;26024233;26154972;26385511;26420826;26969736;26992070;27139832;27193168;27377154;27434818;27459055;27600516;27683217;27732843;27846572;27862975;27871484;27905398;28062851;28076346;28218747;28502770;28581500;28649982;28781166;28832583;28834231;28904123;29211708;29242379;29298432;29301961;29360106;29361316;29437277;29493099;29508533;29557506;2963332;29728366;29769354;29786170;29906447;30059200;30315122;30315277;30410026;30429286;30524438;30705154;30728453;30765414;30779550;30824372;30833945;30975767;31154438;31217245;31373491;31409651;31492838;31844290;31848261;31950173;32157095;32161166;32179686;32329775;32357974;32387766;32488085;32494006;32502341;32897882;32938616;32976585;32983136;33009411;33123756;33243851;33446560;33592498;33691108;33717175;33767452;33912179;33913806;33968037;33981976;34019948;34105348;34165514;34301950;34509645;34561969;34822310;34932366;35051231;35318648;35385551;35580925;36010968;36284347;3757028;37875486;38665916;39531497;40307207;40596516;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Interfering with the axis of RBM7 and P-TEFb provokes cellular hypersensitivity to DNA-damage-inducing agents due to activation of apoptosis. Our work uncovers the importance of stress-dependent stimulation of Pol II pause release, which enables a pro-survival transcriptional response that is crucial for cell fate upon genotoxic insult., [RefSeq, PubMed]; Novel insights into the pathogenesis of lung fibrosis: the RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset. Review article, [RefSeq, PubMed]; RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:25852104, PubMed:27871484). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6K8;Q9NUT4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003727 single-stranded RNA binding;GO:0071889 14-3-3 protein binding;GO:0017069 snRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0051321 meiotic cell cycle;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0006401 RNA catabolic process;GO:0016076 snRNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 20.5,
        "record_id": "Q9Y580-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P51991-1",
        "uniprot_id": [
            {
                "id": "ROA3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P51991",
                "type": "external"
            }
        ],
        "mass": 39595.0,
        "length": 378,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein A3",
        "gene_name": "HNRNPA3",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein A3 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001317178",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317178",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNRNPA3; HNRPA3",
        "gene_names_refseq": "2610510D13Rik; D10S102; FBRNP; HNRNPA3; HNRPA3",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A3; hnRNP A3",
        "protein_names_refseq": "epididymis secretory sperm binding protein; heterogeneous nuclear ribonucleoprotein A3 isoform a",
        "tax_id": 9606,
        "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); silicosis (Disease Ontology:DOID:10325); neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:220988);  (R-HSA-72163);  (R-HSA-72203);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 5,
        "publication_count": 242,
        "publication_id_list": "10669729;10882114;11014198;11060040;11101529;11233976;11237011;11747608;11886857;11991638;12176931;12411573;12414731;12477934;14519844;14625303;14654843;14713954;14749727;14762106;15037765;15084397;15565158;16314458;16408927;16809785;16964243;17095540;17128255;17287340;17322306;17332742;17487921;17606899;17919748;18220336;18288197;18322460;18452278;18593880;18669648;18691976;18767875;19103666;19165350;19217410;19413330;19415658;19536130;19562805;19608861;19651622;19664995;19690332;20058876;20068231;20166139;20305658;20423332;20695905;20980672;21295486;21406692;21536652;21740066;2176635;21911577;22110043;22121020;22365833;22813749;22959432;22961380;23186163;23222130;23236153;23301498;23345524;23555621;23874216;24076191;24129315;24149845;24196718;24275569;24304693;24316715;24407421;24448447;24714562;24715725;24737827;24914973;24981863;25218447;25301780;25301781;25505266;25555158;25576301;2558966;25810538;25892735;26092250;26154972;26375851;26385511;26420826;26969736;26992070;27108190;27377154;27459055;27543614;27600516;27683217;27726376;27846572;27920218;28062851;28076346;28096519;28228285;28502770;28510447;28514659;28781166;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29301961;29351928;29360106;29361316;29393594;29493099;29508533;29557506;29632711;2963332;29693745;29741879;29769354;29786170;29789417;29902443;30139799;30257008;30315277;30429286;30444036;30484775;30599162;30705154;30728453;30765414;30975767;31154438;31217245;31222486;31373491;31409651;31844290;31848261;31998317;32119511;32157095;32179686;32321712;32329775;32350084;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33141586;33177556;33214551;33243851;33298915;33392160;33446560;33465208;33469008;33592498;33912179;33968037;34019948;34171305;34185709;34211107;34229054;34301950;34405274;34725712;34822310;34932366;35051231;35083852;35154160;35177536;35215846;35251023;35318648;35385551;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37217939;3757028;37938771;38253038;38665916;39990658;40307207;40596516;40914422;8352591;8566756;8608946;9016565;9242493;9409616;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Publication Status: Online-Only, [RefSeq, PubMed]; Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicated a specific interaction of A3B with hnRNP A3 (heterogeneous nuclear ribonucleoprotein). This interaction was verified by co-immunoprecipitation and was found to be RNA-dependent. Furthermore, A3B and hnRNP A3 colocalized as evident from immunofluorescence analysis., [RefSeq, PubMed]; These biochemical properties of hnRNP A3 suggest that hnRNP A3 can participate in telomere regulation in vivo., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPF4;Q53RW7;Q6URK5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071013 catalytic step 2 spliceosome;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 25.4,
        "record_id": "P51991-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H6Y7-1",
        "uniprot_id": [
            {
                "id": "RN167_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6Y7",
                "type": "external"
            }
        ],
        "mass": 38299.0,
        "length": 350,
        "protein_name": "E3 ubiquitin-protein ligase RNF167",
        "gene_name": "RNF167",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF167 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001307285",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307285",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNF167; LP2254; RING105",
        "gene_names_refseq": "5730408C10Rik; LP2254; RING105; RNF167",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF167; 2.3.2.27; RING finger protein 167",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RNF167 isoform a precursor; E3 ubiquitin-protein ligase RNF167; RING-type E3 ubiquitin transferase RNF167",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26001)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;15498874;16314844;20068231;23129617;23353890;23481700;24387786;24715725;25418920;25502872;25645385;25892735;26154972;26811146;26929215;26992070;27808481;27846572;27862975;27920218;28063628;28228285;28467828;28649982;28832583;28834231;28855257;28904123;29242379;29314611;29393594;29508533;29632046;29632711;30315122;30484775;30573663;30833945;31154438;31217245;31222486;31844290;31998317;32157095;32161166;32350084;32409562;32502341;32983136;33141586;33298915;33594058;33650289;33912179;33936100;34171305;34357683;34433824;35051231;35114100;35154160;35251023;35561310;35580925;36215666;36241641",
        "class_list": "",
        "function": "E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor., [RefSeq, PubMed]; RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Publication Status: Online-Only, [RefSeq, PubMed]; RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTK8;I3L0L6;Q6XYE0;Q8NDC1;Q9Y3V1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045786 negative regulation of cell cycle;GO:0070534 protein K63-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9H6Y7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZUM4-1",
        "uniprot_id": [
            {
                "id": "RHG27_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZUM4",
                "type": "external"
            }
        ],
        "mass": 98396.0,
        "length": 889,
        "protein_name": "Rho GTPase-activating protein 27",
        "gene_name": "ARHGAP27",
        "organism": "Human",
        "refseq_name": "rho GTPase-activating protein 27 isoform d",
        "refseq_ac": [
            {
                "id": "NP_001269219",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269219",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ARHGAP27; CAMGAP1; PP905; SH3D20",
        "gene_names_refseq": "ARHGAP27; CAMGAP1; PP905; SH3D20; SH3P20",
        "protein_names_uniprotkb": "Rho GTPase-activating protein 27; CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; Rho-type GTPase-activating protein 27; SH3 domain-containing protein 20",
        "protein_names_refseq": "CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; SH3 domain containing 20; SH3 domain-containing protein 20; rho GTPase-activating protein 27 isoform d; rho GTPase-activating protein 27; rho-type GTPase-activating protein 27",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:201176);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 3,
        "publication_count": 300,
        "publication_id_list": "10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;10958683;11007481;11058585;11085924;11149925;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12172552;12195014;12221096;12351724;12432077;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15339924;15342493;15485661;15492870;15498874;15507211;15579468;15601624;15611138;15728722;15850391;15858067;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16473593;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16777452;16777849;16862148;16896804;16914516;16968698;17064668;17077126;17145773;17196961;17214551;17244649;17583407;17599059;17702745;17765681;17804252;17932950;17976533;18006505;18045877;18056264;18218625;18249095;18347018;18363964;18396277;18426980;18653540;18786931;18835169;18838382;18929667;19269969;19494238;19605563;19673492;19713215;19934221;20400958;20460433;20679435;20810653;21148482;21454492;21542010;21565175;21613211;21685891;21730051;21865595;21989057;22004470;22096251;22298643;22407364;22461490;22475431;22571869;22608513;22734669;22970203;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23940355;24086303;24259668;24275569;24335996;24352656;24584464;24859002;24933155;24960694;24996924;25024229;25211221;25418920;25428919;25576301;25704760;25721503;25795300;25862245;25880248;25892735;25963737;26129894;26154972;26299518;26529257;26598554;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27846572;27920218;28028151;28063628;28114311;28196833;28228285;28825699;28832583;28860633;29089502;29242379;29351928;29358323;29382922;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30061681;30315122;30379171;30429286;30853411;31844290;31871319;32203420;32357974;32502341;33141586;33298915;33912179;33936100;34211107;34932366;35051231;35580925;39894887;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9113980;9268338;9305890;9405671;9438849;9490638;9497316;9582072;9659915;9670022;9792683;9822598;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FU35;A8K3N5;C9JTF3;Q494U0;Q6NWZ8;Q8WY58",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0006898 receptor-mediated endocytosis;GO:0006897 endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 30.4,
        "record_id": "Q6ZUM4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02161-1",
        "uniprot_id": [
            {
                "id": "RHD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02161",
                "type": "external"
            }
        ],
        "mass": 45211.0,
        "length": 417,
        "protein_name": "Blood group Rh(D) polypeptide",
        "gene_name": "RHD",
        "organism": "Human",
        "refseq_name": "blood group Rh(D) polypeptide isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001121163",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121163",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RHD",
        "gene_names_refseq": "CD240D; DIIIc; HDFNRH; RH30; RHCED; RHDVA(TT); RHDel; RHD; RHPII; RHXIII; RH; Rh4; RhDCw; RhII; RhK562-II; RhPI; SLC42A5",
        "protein_names_uniprotkb": "Blood group Rh(D) polypeptide; RHXIII; Rh polypeptide 2; RhPII; Rhesus D antigen",
        "protein_names_refseq": "D antigen (DCS); RH polypeptide 2; Rh blood group C antigen; Rh blood group CcEe antigen; Rh blood group D antigen weak D type 160; Rh blood group antigen Evans; Rh blood group, D anitgen; RhD antigen; RhD blood group antigen; RhD glycoprotein; RhD polypeptide; Rhesus D blood group protein; Rhesus blood group antigen D; Rhesus system D polypeptide; blood group Rh(D) polypeptide isoform 2; blood group Rh(D) polypeptide; blood group antigen D; blood group protein RHD; rhesus D antigen; weak RHD antigen",
        "tax_id": 9606,
        "disease": "renal tubular acidosis (Disease Ontology:DOID:14219); Rh isoimmunization (Disease Ontology:DOID:4175); hemolytic disease of fetus and newborn, RH-induced (MONDO:MONDO:0859172)",
        "pathway": " (hsa:6007);  (R-HSA-9037628)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10805260;10845894;11237011;11902138;12070041;1379850;1438298;1544931;16510313;16959974;17761830;1824267;1898705;24441145;25628657;29557506;3131772;3135863;3142870;3146980;35051231;36010968;38469779;38595257;39276265;7536710;7606008;7741145;7916743;8080999;8180407;8329718;9326237;9864185",
        "class_list": "",
        "function": "Association of ABO and Rhesus blood groups with symptom emergence in scabies: a cross-sectional study. Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of 5 new RHD alleles, dubbed DAU-0 to DAU-4, that share a T379M substitution and occurr in a cDe haplotype., [RefSeq, PubMed]; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane., [UniProtKB]; Molecular and Family Analyses of a Novel RHD1058G>C Allele in a Chinese RhD Population., [RefSeq, PubMed]; RHCE represents the ancestral RH position, while RHD is the duplicated gene, [RefSeq, PubMed]; The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; [Molecular biology analysis of 2 rare RhD variant individuals with RHD*DEL37]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q02162;Q07618;Q16147;Q16235;Q16355;Q5VSK0;Q5XLS9;Q5XLT1;Q5XLT2;Q9NPK0;Q9UQ20;Q9UQ21;Q9UQ22;Q9UQ23",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008519 ammonium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0072488 ammonium transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q02161-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    }
]